Publications by authors named "Bhaskar Veldurthy"

2 Publications

  • Page 1 of 1

An efficient synthesis of organic carbonates: atom economic protocol with a new catalytic system.

Chem Commun (Camb) 2004 Mar 18(6):734-5. Epub 2004 Feb 18.

Institut de Recherches sur la Catalyse du CNRS, 2 avenue A. Einstein, 69626 Villeurbanne, France.

Selective and solvent free synthesis of unsymmetrical organic carbonates catalysed by a reusable MgLa mixed oxide is achieved for the first time via direct condensation of an alcohol and diethyl carbonate in economic route with excellent yields.
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http://dx.doi.org/10.1039/b316050eDOI Listing
March 2004

Highly efficient "tight fit" immobilization of alpha-chymotrypsin in mesoporous MCM-41: a novel approach using precursor immobilization and activation.

Biotechnol Prog 2003 Mar-Apr;19(2):346-51

Biotransformations Laboratory, Organic Division-I, and Inorganic Chemistry Division, Indian Institute of Chemical Technology, Hyderabad-500 007, India.

The zymogen alpha-chymotrypsinogen A is bound to mesoporous silica MCM-41 with a protein loading of 170 mg/g solid (MCM-Z) by a simple stirring in aqueous tris-HCl buffer (pH 7.2). The bound zymogen is then activated with trypsin to obtain alpha-chymotrypsin immobilized on MCM-41 (MCM-E.I) that displays an effective enzyme activity corresponding to 65 mg protein/g of solid support (3250 BTEE units/g). A direct immobilization of commercially available alpha-chymotrypsin (MCM-E.II) gives lower loading (1250 BTEE units/g). Protein content of the solid support after immobilization is confirmed by thermogravimetric analysis (TGA). The enzyme is tightly bound to the support and can be used over 100 recycles over 1 week in aqueous as well as reverse micellar media. The immobilized enzyme (MCM-E.I) has been used for resolution of N-acetyl-dl-amino acid esters and racemic trans-4-methoxy-3-phenylglycidic acid (PGA) methyl ester.
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http://dx.doi.org/10.1021/bp025678sDOI Listing
March 2004
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