Bharati Bapat

Bharati Bapat

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Bharati Bapat

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An integrative DNA methylation model for improved prognostication of postsurgery recurrence and therapy in prostate cancer patients.

Authors:
Renu Jeyapala Shivani Kamdar Ekaterina Olkhov-Mitsel Andrea J Savio Fang Zhao Carmelle Cuizon Richard Sc Liu Alexandre Zlotta Neil Fleshner Theodorus van der Kwast Bharati Bapat

Urol Oncol 2020 Feb 24;38(2):39.e1-39.e9. Epub 2019 Sep 24.

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON; Institute of Medical Science, University of Toronto, Toronto, ON; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON; Department of Surgery and Surgical Oncology, Division of Urology, University Health Network, Toronto, ON. Electronic address:

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http://dx.doi.org/10.1016/j.urolonc.2019.08.017DOI Listing
February 2020

Methylation Markers in Prostate Biopsies Are Prognosticators for Late Biochemical Recurrence and Therapy after Surgery in Prostate Cancer Patients.

Authors:
Andrea J Savio Shivani Kamdar Renu Jeyapala Ekaterina Olkhov-Mitsel Carmelle Cuizon Antonio Finelli Alexandre R Zlotta Ants Toi Neil E Fleshner Theodorus van der Kwast Bharati Bapat

J Mol Diagn 2020 Jan 9;22(1):30-39. Epub 2019 Oct 9.

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Division of Urology, Department of Surgery and Surgical Oncology, University Health Network, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2019.08.003DOI Listing
January 2020

Temporal stability and prognostic biomarker potential of the prostate cancer urine transcriptome.

Authors:
Jouhyun Jeon Ekaterina Olkhov-Mitsel Honglei Xie Cindy Q Yao Fang Zhao Sahar Jahangiri Carmelle Cuizon Seville Scarcello Renu Jeyapala John D Watson Michael Fraser Jessica Ray Kristina Commisso Andrew Loblaw Neil E Fleshner Robert G Bristow Michelle Downes Danny Vesprini Stanley Liu Bharati Bapat Paul C Boutros

J Natl Cancer Inst 2019 Jun 4. Epub 2019 Jun 4.

Ontario Institute for Cancer Research, Toronto, Canada.

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http://dx.doi.org/10.1093/jnci/djz112DOI Listing
June 2019

Combining urinary DNA methylation and cell-free microRNA biomarkers for improved monitoring of prostate cancer patients on active surveillance.

Authors:
Fang Zhao Danny Vesprini Richard S C Liu Ekaterina Olkhov-Mitsel Laurence H Klotz Andrew Loblaw Stanley K Liu Bharati Bapat

Urol Oncol 2019 05 16;37(5):297.e9-297.e17. Epub 2019 Feb 16.

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada; Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.urolonc.2019.01.031DOI Listing
May 2019

GBX2 Methylation Is a Novel Prognostic Biomarker and Improves Prediction of Biochemical Recurrence Among Patients with Prostate Cancer Negative for Intraductal Carcinoma and Cribriform Architecture.

Authors:
Renu Jeyapala Andrea J Savio Ekaterina Olkhov-Mitsel Shivani Kamdar Fang Zhao Carmelle Cuizon Richard S C Liu Alex Zlotta Neil Fleshner Theodorus van der Kwast Bharati Bapat

Eur Urol Oncol 2019 May 1;2(3):231-238. Epub 2018 Sep 1.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada; Institute of Medical Science, University of Toronto, Toronto, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; Departments of Surgery and Surgical Oncology, Division of Urology, University Health Network, Toronto, Canada; Department of Pathology and Laboratory Medicine, University Health Network, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.euo.2018.08.003DOI Listing
May 2019

Exploring targets of TET2-mediated methylation reprogramming as potential discriminators of prostate cancer progression.

Authors:
Shivani Kamdar Ruth Isserlin Theodorus Van der Kwast Alexandre R Zlotta Gary D Bader Neil E Fleshner Bharati Bapat

Clin Epigenetics 2019 03 27;11(1):54. Epub 2019 Mar 27.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 60 Murray Street, L6-304B, Toronto, ON, M5T 3L9, Canada.

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http://dx.doi.org/10.1186/s13148-019-0651-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438015PMC
March 2019

Are there differences between de novo and secondary upper tract urothelial carcinoma tumours?

Authors:
Hanan Goldberg Douglas C Cheung Thenappan Chandrasekar Zachary Klaassen Christopher J D Wallis Girish S Kulkarni Rashid Sayyid Andrew Evans Mehdi Masoomian Bharati Bapat Theodorus van der Kwast Robert J Hamilton Alexandre Zlotta Neil Fleshner

Can Urol Assoc J 2019 Jan 21:E292-E299. Epub 2019 Jan 21.

Division of Urology, Department of Surgical Oncology, Princess Margaret Cancer Center, University Health Network and the University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.5489/cuaj.5595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754256PMC
January 2019

epiCaPture: A Urine DNA Methylation Test for Early Detection of Aggressive Prostate Cancer.

Authors:
Eve O'Reilly Alexandra V Tuzova Anna L Walsh Niamh M Russell Odharnaith O'Brien Sarah Kelly Odharna Ni Dhomhnallain Liam DeBarra Connie M Dale Rick Brugman Gavin Clarke Olivia Schmidt Shane O'Meachair Dattatraya Patil Kathryn L Pellegrini Neil Fleshner Julia Garcia Fang Zhao Stephen Finn Robert Mills Marcelino Y Hanna Rachel Hurst Elizabeth McEvoy William M Gallagher Rustom P Manecksha Colin S Cooper Daniel S Brewer Bharati Bapat Martin G Sanda Jeremy Clark Antoinette S Perry

JCO Precis Oncol 2019 14;2019. Epub 2019 Jan 14.

University College Dublin.

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http://dx.doi.org/10.1200/PO.18.00134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383793PMC
January 2019

A urine-based DNA methylation assay, ProCUrE, to identify clinically significant prostate cancer.

Authors:
Fang Zhao Ekaterina Olkhov-Mitsel Shivani Kamdar Renu Jeyapala Julia Garcia Rachel Hurst Marcelino Yazbek Hanna Robert Mills Alexandra V Tuzova Eve O'Reilly Sarah Kelly Colin Cooper Daniel Brewer Antoinette S Perry Jeremy Clark Neil Fleshner Bharati Bapat

Clin Epigenetics 2018 11 23;10(1):147. Epub 2018 Nov 23.

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada.

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https://clinicalepigeneticsjournal.biomedcentral.com/article
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http://dx.doi.org/10.1186/s13148-018-0575-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260648PMC
November 2018

Assessment of Serum microRNA Biomarkers to Predict Reclassification of Prostate Cancer in Patients on Active Surveillance.

Authors:
Richard S C Liu Ekaterina Olkhov-Mitsel Renu Jeyapala Fang Zhao Kristina Commisso Laurence Klotz Andrew Loblaw Stanley K Liu Danny Vesprini Neil E Fleshner Bharati Bapat

J Urol 2018 06 12;199(6):1475-1481. Epub 2017 Dec 12.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Lunenfeld Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00225347177806
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http://dx.doi.org/10.1016/j.juro.2017.12.006DOI Listing
June 2018

Re: Urinary DNA Methylation Biomarkers for Noninvasive Prediction of Aggressive Disease in Patients with Prostate Cancer on Active Surveillance: F. Zhao, E. Olkhov-Mitsel, T. van der Kwast, J. Sykes, D. Zdravic, V. Venkateswaran, A. R. Zlotta, A. Loblaw, N. E. Fleshner, L. Klotz, D. Vesprini and B. Bapat J Urol 2017;197:335-341.

Authors:
Fang Zhao Renu Jeyapala Ekaterina Olkhov-Mitsel Danny Vesprini Neil E Fleshner Bharati Bapat

J Urol 2018 05 9;199(5):1354-1355. Epub 2018 Feb 9.

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.juro.2017.10.061DOI Listing
May 2018

Association of rs2282679 A>C polymorphism in vitamin D binding protein gene with colorectal cancer risk and survival: effect modification by dietary vitamin D intake.

Authors:
Yun Zhu Peizhong Peter Wang Guangju Zhai Bharati Bapat Sevtap Savas Jennifer R Woodrow Peter T Campbell Yuming Li Ning Yang Xin Zhou Elizabeth Dicks John R Mclaughlin Patrick S Parfrey

BMC Cancer 2018 02 6;18(1):155. Epub 2018 Feb 6.

Clinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.

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http://dx.doi.org/10.1186/s12885-018-4026-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802053PMC
February 2018

Vitamin D receptor and calcium-sensing receptor polymorphisms and colorectal cancer survival in the Newfoundland population.

Authors:
Yun Zhu Peizhong Peter Wang Guangju Zhai Bharati Bapat Sevtap Savas Jennifer R Woodrow Ishor Sharma Yuming Li Xin Zhou Ning Yang Peter T Campbell Elizabeth Dicks Patrick S Parfrey John R Mclaughlin

Br J Cancer 2017 Sep 1;117(6):898-906. Epub 2017 Aug 1.

Division of Epidemiology, Public Health Ontario, Toronto, ON M5G 1V2, Canada.

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http://dx.doi.org/10.1038/bjc.2017.242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589991PMC
September 2017

Distinct DNA methylation alterations are associated with cribriform architecture and intraductal carcinoma in Gleason pattern 4 prostate tumors.

Authors:
Ekaterina Olkhov-Mitsel Farshid Siadat Ken Kron Liyang Liu Andrea J Savio John Trachtenberg Neil Fleshner Theodorus van der Kwast Bharati Bapat

Oncol Lett 2017 Jul 9;14(1):390-396. Epub 2017 May 9.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5T3L9, Canada.

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http://dx.doi.org/10.3892/ol.2017.6140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494878PMC
July 2017

Modulation of transcription factor binding and epigenetic regulation of the MLH1 CpG island and shore by polymorphism rs1800734 in colorectal cancer.

Authors:
Andrea J Savio Bharati Bapat

Epigenetics 2017 06 17;12(6):441-448. Epub 2017 Mar 17.

a Lunenfeld-Tanenbaum Research Institute, Sinai Health System , Toronto , Ontario , Canada.

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http://dx.doi.org/10.1080/15592294.2017.1305527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501216PMC
June 2017

Epigenome-Wide DNA Methylation Profiling Identifies Differential Methylation Biomarkers in High-Grade Bladder Cancer.

Authors:
Ekaterina Olkhov-Mitsel Andrea J Savio Ken J Kron Vaijayanti V Pethe Thomas Hermanns Neil E Fleshner Bas W van Rhijn Theodorus H van der Kwast Alexandre R Zlotta Bharati Bapat

Transl Oncol 2017 Apr 3;10(2):168-177. Epub 2017 Feb 3.

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 60 Murray St., Toronto, Ontario, Canada, M5T 3L9; Department of Laboratory Medicine and Pathobiology, University of Toronto, 27 King's College Circle, Toronto, Ontario, Canada, M5S 1A1; Department of Pathology, University Health Network, 200 Elizabeth St., Toronto, Ontario, Canada, M5G 2C4. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19365233163025
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http://dx.doi.org/10.1016/j.tranon.2017.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293735PMC
April 2017

Germline Mutations in the Kallikrein 6 Region and Predisposition for Aggressive Prostate Cancer.

Authors:
Laurent Briollais Hilmi Ozcelik Jingxiong Xu Maciej Kwiatkowski Emilie Lalonde Dorota H Sendorek Neil E Fleshner Franz Recker Cynthia Kuk Ekaterina Olkhov-Mitsel Sevtap Savas Sally Hanna Tristan Juvet Geoffrey A Hunter Matt Friedlander Hong Li Karen Chadwick Ioannis Prassas Antoninus Soosaipillai Marco Randazzo John Trachtenberg Ants Toi Yu-Jia Shiah Michael Fraser Theodorus van der Kwast Robert G Bristow Bharati Bapat Eleftherios P Diamandis Paul C Boutros Alexandre R Zlotta

J Natl Cancer Inst 2017 04;109(4)

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1093/jnci/djw258DOI Listing
April 2017

Urinary DNA Methylation Biomarkers for Noninvasive Prediction of Aggressive Disease in Patients with Prostate Cancer on Active Surveillance.

Authors:
Fang Zhao Ekaterina Olkhov-Mitsel Theodorus van der Kwast Jenna Sykes Darko Zdravic Vasundara Venkateswaran Alexandre R Zlotta Andrew Loblaw Neil E Fleshner Laurence Klotz Danny Vesprini Bharati Bapat

J Urol 2017 02 18;197(2):335-341. Epub 2016 Aug 18.

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Department of Pathology, University Health Network, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2016.08.081DOI Listing
February 2017

Metformin Elicits Antitumor Effects and Downregulates the Histone Methyltransferase Multiple Myeloma SET Domain (MMSET) in Prostate Cancer Cells.

Authors:
Nicole M A White-Al Habeeb Julia Garcia Neil Fleshner Bharati Bapat

Prostate 2016 12 12;76(16):1507-1518. Epub 2016 Jul 12.

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pros.23235DOI Listing
December 2016

Dynamic interplay between locus-specific DNA methylation and hydroxymethylation regulates distinct biological pathways in prostate carcinogenesis.

Authors:
Shivani N Kamdar Linh T Ho Ken J Kron Ruth Isserlin Theodorus van der Kwast Alexandre R Zlotta Neil E Fleshner Gary Bader Bharati Bapat

Clin Epigenetics 2016 15;8:32. Epub 2016 Mar 15.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON Canada ; Mount Sinai Hospital, Lunenfeld-Tanenbaum Research Institute, Toronto, ON Canada.

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http://dx.doi.org/10.1186/s13148-016-0195-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791926PMC
April 2016

Promoter methylation of ITF2, but not APC, is associated with microsatellite instability in two populations of colorectal cancer patients.

Authors:
Andrea J Savio Darshana Daftary Elizabeth Dicks Daniel D Buchanan Patrick S Parfrey Joanne P Young Daniel Weisenberger Roger C Green Steven Gallinger John R McLaughlin Julia A Knight Bharati Bapat

BMC Cancer 2016 Feb 17;16:113. Epub 2016 Feb 17.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1186/s12885-016-2149-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756469PMC
February 2016

Beyond the island: epigenetic biomarkers of colorectal and prostate cancer.

Authors:
Andrea J Savio Bharati Bapat

Methods Mol Biol 2015 ;1238:103-24

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-1-4939-1804-1_6DOI Listing
July 2015

Molecular and clinical support for a four-tiered grading system for bladder cancer based on the WHO 1973 and 2004 classifications.

Authors:
Bas W G van Rhijn Mireia Musquera Liyang Liu André N Vis Tahlita C M Zuiverloon Geert J L H van Leenders Wim J Kirkels Ellen C Zwarthoff Egbert R Boevé Adriaan C Jöbsis Bharati Bapat Michael A S Jewett Alexandre R Zlotta Theo H van der Kwast

Mod Pathol 2015 May 28;28(5):695-705. Epub 2014 Nov 28.

1] Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands [2] Department of Surgical Pathology, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/modpathol.2014.154DOI Listing
May 2015

Association of the colorectal CpG island methylator phenotype with molecular features, risk factors, and family history.

Authors:
Daniel J Weisenberger A Joan Levine Tiffany I Long Daniel D Buchanan Rhiannon Walters Mark Clendenning Christophe Rosty Amit D Joshi Mariana C Stern Loic LeMarchand Noralane M Lindor Darshana Daftary Steven Gallinger Teresa Selander Bharati Bapat Polly A Newcomb Peter T Campbell Graham Casey Dennis J Ahnen John A Baron Robert W Haile John L Hopper Joanne P Young Peter W Laird Kimberly D Siegmund

Cancer Epidemiol Biomarkers Prev 2015 Mar 13;24(3):512-519. Epub 2015 Jan 13.

Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-14-1161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355081PMC
March 2015

Integrated analysis of epigenomic and genomic changes by DNA methylation dependent mechanisms provides potential novel biomarkers for prostate cancer.

Authors:
Nicole M A White-Al Habeeb Linh T Ho Ekaterina Olkhov-Mitsel Ken Kron Vaijayanti Pethe Melanie Lehman Lidija Jovanovic Neil Fleshner Theodorus van der Kwast Colleen C Nelson Bharati Bapat

Oncotarget 2014 Sep;5(17):7858-69

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital. Department of Laboratory Medicine and Pathobiology, University of Toronto. Department of Pathology, University Health Network, Toronto, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202166PMC
http://dx.doi.org/10.18632/oncotarget.2313DOI Listing
September 2014

FGFR3 mutations, but not FGFR3 expression and FGFR3 copy-number variations, are associated with favourable non-muscle invasive bladder cancer.

Authors:
Yann Neuzillet Bas W G van Rhijn Nadia L Prigoda Bharati Bapat Liyang Liu Peter J Bostrom Neil E Fleshner Brenda L Gallie Alexandre R Zlotta Michael A S Jewett Theo H van der Kwast

Virchows Arch 2014 Aug 1;465(2):207-13. Epub 2014 Jun 1.

Department of Surgical Oncology (Urology), The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00428-014-1596-4DOI Listing
August 2014

Evaluation and prognostic significance of ACAT1 as a marker of prostate cancer progression.

Authors:
Punit Saraon Dominique Trudel Ken Kron Apostolos Dmitromanolakis John Trachtenberg Bharati Bapat Theodorus van der Kwast Keith A Jarvi Eleftherios P Diamandis

Prostate 2014 Apr 6;74(4):372-80. Epub 2013 Dec 6.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/pros.22758DOI Listing
April 2014

Novel multiplex MethyLight protocol for detection of DNA methylation in patient tissues and bodily fluids.

Authors:
Ekaterina Olkhov-Mitsel Darko Zdravic Ken Kron Theodorus van der Kwast Neil Fleshner Bharati Bapat

Sci Rep 2014 Mar 21;4:4432. Epub 2014 Mar 21.

1] Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada [2] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada [3] Department of Pathology and Laboratory Medicine, University Health Network, Toronto, Ontario, Canada.

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http://www.nature.com/articles/srep04432
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http://dx.doi.org/10.1038/srep04432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961737PMC
March 2014

Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database.

Authors:
Bryony A Thompson Amanda B Spurdle John-Paul Plazzer Marc S Greenblatt Kiwamu Akagi Fahd Al-Mulla Bharati Bapat Inge Bernstein Gabriel Capellá Johan T den Dunnen Desiree du Sart Aurelie Fabre Michael P Farrell Susan M Farrington Ian M Frayling Thierry Frebourg David E Goldgar Christopher D Heinen Elke Holinski-Feder Maija Kohonen-Corish Kristina Lagerstedt Robinson Suet Yi Leung Alexandra Martins Pal Moller Monika Morak Minna Nystrom Paivi Peltomaki Marta Pineda Ming Qi Rajkumar Ramesar Lene Juel Rasmussen Brigitte Royer-Pokora Rodney J Scott Rolf Sijmons Sean V Tavtigian Carli M Tops Thomas Weber Juul Wijnen Michael O Woods Finlay Macrae Maurizio Genuardi

Nat Genet 2014 Feb 22;46(2):107-115. Epub 2013 Dec 22.

Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Italy.

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http://dx.doi.org/10.1038/ng.2854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294709PMC
February 2014

Altered DNA methylation landscapes of polycomb-repressed loci are associated with prostate cancer progression and ERG oncogene expression in prostate cancer.

Authors:
Ken Kron Dominique Trudel Vaijayanti Pethe Laurent Briollais Neil Fleshner Theodorus van der Kwast Bharati Bapat

Clin Cancer Res 2013 Jul 2;19(13):3450-61. Epub 2013 Apr 2.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-12-3139DOI Listing
July 2013

MLH1 region polymorphisms show a significant association with CpG island shore methylation in a large cohort of healthy individuals.

Authors:
Andrea J Savio Mathieu Lemire Miralem Mrkonjic Steven Gallinger Brent W Zanke Thomas J Hudson Bharati Bapat

PLoS One 2012 11;7(12):e51531. Epub 2012 Dec 11.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051531PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519863PMC
May 2013

Vitamin D intake is negatively associated with promoter methylation of the Wnt antagonist gene DKK1 in a large group of colorectal cancer patients.

Authors:
James B Rawson Zhouyu Sun Elizabeth Dicks Darshana Daftary Patrick S Parfrey Roger C Green Steven Gallinger John R McLaughlin Peizhong P Wang Julia A Knight Bharati Bapat

Nutr Cancer 2012 11;64(7):919-28. Epub 2012 Sep 11.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1080/01635581.2012.711418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323165PMC
March 2013

Patients with Lynch syndrome mismatch repair gene mutations are at higher risk for not only upper tract urothelial cancer but also bladder cancer.

Authors:
Sean C Skeldon Kara Semotiuk Melyssa Aronson Spring Holter Steven Gallinger Aaron Pollett Cynthia Kuk Bas van Rhijn Peter Bostrom Zane Cohen Neil E Fleshner Michael A Jewett Sally Hanna Shahrokh F Shariat Theodorus H Van Der Kwast Andrew Evans Jim Catto Bharati Bapat Alexandre R Zlotta

Eur Urol 2013 Feb 2;63(2):379-85. Epub 2012 Aug 2.

Department of Surgical Oncology, Urology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.eururo.2012.07.047DOI Listing
February 2013

Prognostic value of molecular markers, sub-stage and European Organisation for the Research and Treatment of Cancer risk scores in primary T1 bladder cancer.

Authors:
Bas W G van Rhijn Liyang Liu André N Vis Peter J Bostrom Tahlita C M Zuiverloon Neil E Fleshner Madelon N M van der Aa Sultan S Alkhateeb Chris H Bangma Michael A S Jewett Ellen C Zwarthoff Bharati Bapat Theo H van der Kwast Alexandre R Zlotta

BJU Int 2012 Oct 27;110(8):1169-76. Epub 2012 Mar 27.

Division of Urology, University Health Network, Princess Margaret Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/j.1464-410X.2012.10996.xDOI Listing
October 2012

Lynch syndrome in a predominantly Afrocentric population: a clinicopathological and genetic study.

Authors:
Joseph M Plummer Sheray N Chin Melyssa Aronson Rondell P Graham Nadia P Williams Bharati Bapat Gillian Wharfe Aaron Pollett Steven Gallinger

Can J Surg 2012 Oct;55(5):294-300

The Department of Surgery, University of the West Indies, Mona, Jamaica.

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http://dx.doi.org/10.1503/cjs.037410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468640PMC
October 2012

Strategies for discovery and validation of methylated and hydroxymethylated DNA biomarkers.

Authors:
Ekaterina Olkhov-Mitsel Bharati Bapat

Cancer Med 2012 Oct 14;1(2):237-60. Epub 2012 Sep 14.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cam4.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544446PMC
October 2012

Quantitative DNA methylation analysis of genes coding for kallikrein-related peptidases 6 and 10 as biomarkers for prostate cancer.

Authors:
Ekaterina Olkhov-Mitsel Theodorus Van der Kwast Ken J Kron Hilmi Ozcelik Laurent Briollais Christine Massey Franz Recker Maciej Kwiatkowski Neil E Fleshner Eleftherios P Diamandis Alexandre R Zlotta Bharati Bapat

Epigenetics 2012 Sep 9;7(9):1037-45. Epub 2012 Aug 9.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.4161/epi.21524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515013PMC
September 2012

Epigenetic biomarkers in colorectal cancer diagnostics.

Authors:
James B Rawson Bharati Bapat

Expert Rev Mol Diagn 2012 Jun;12(5):499-509

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, L6-304B, Box 30, Toronto, ON M5G 1X5, Canada.

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http://dx.doi.org/10.1586/erm.12.39DOI Listing
June 2012

Correlation of ERG expression and DNA methylation biomarkers with adverse clinicopathologic features of prostate cancer.

Authors:
Ken Kron Liyang Liu Dominique Trudel Vaijayanti Pethe John Trachtenberg Neil Fleshner Bharati Bapat Theodorus van der Kwast

Clin Cancer Res 2012 May 27;18(10):2896-904. Epub 2012 Mar 27.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-2901DOI Listing
May 2012

Epigenetic regulation of kallikrein-related peptidases: there is a whole new world out there.

Authors:
Maria D Pasic Ekaterina Olkhov Bharati Bapat George M Yousef

Biol Chem 2012 Apr;393(5):319-30

Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1515/hsz-2011-0273DOI Listing
April 2012

Colorectal and other cancer risks for carriers and noncarriers from families with a DNA mismatch repair gene mutation: a prospective cohort study.

Authors:
Aung Ko Win Joanne P Young Noralane M Lindor Katherine M Tucker Dennis J Ahnen Graeme P Young Daniel D Buchanan Mark Clendenning Graham G Giles Ingrid Winship Finlay A Macrae Jack Goldblatt Melissa C Southey Julie Arnold Stephen N Thibodeau Shanaka R Gunawardena Bharati Bapat John A Baron Graham Casey Steven Gallinger Loïc Le Marchand Polly A Newcomb Robert W Haile John L Hopper Mark A Jenkins

J Clin Oncol 2012 Mar 13;30(9):958-64. Epub 2012 Feb 13.

The University of Melbourne, Australia.

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http://dx.doi.org/10.1200/JCO.2011.39.5590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341109PMC
March 2012

Comparison of clinical schemas and morphologic features in predicting Lynch syndrome in mutation-positive patients with endometrial cancer encountered in the context of familial gastrointestinal cancer registries.

Authors:
Paul Ryan Anna Marie Mulligan Melyssa Aronson Sarah E Ferguson Bharati Bapat Kara Semotiuk Spring Holter Janice Kwon Steve E Kalloger C Blake Gilks Steven Gallinger Aaron Pollett Blaise A Clarke

Cancer 2012 Feb 30;118(3):681-8. Epub 2011 Jun 30.

Department of Pathology, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1002/cncr.26323
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February 2012

The FGFR3 mutation is related to favorable pT1 bladder cancer.

Authors:
Bas W G van Rhijn Theo H van der Kwast Liyang Liu Neil E Fleshner Peter J Bostrom André N Vis Sultan S Alkhateeb Chris H Bangma Michael A S Jewett Ellen C Zwarthoff Alexandre R Zlotta Bharati Bapat

J Urol 2012 Jan 17;187(1):310-4. Epub 2011 Nov 17.

Division of Urology, Princess Margaret Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.juro.2011.09.008DOI Listing
January 2012

Association of tissue promoter methylation levels of APC, TGFβ2, HOXD3 and RASSF1A with prostate cancer progression.

Authors:
Liyang Liu Ken J Kron Vaijayanti V Pethe Nino Demetrashvili Michael E Nesbitt John Trachtenberg Hilmi Ozcelik Neil E Fleshner Laurent Briollais Theodorus H van der Kwast Bharati Bapat

Int J Cancer 2011 Nov 13;129(10):2454-62. Epub 2011 Apr 13.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/ijc.25908DOI Listing
November 2011

Rac1b recruits Dishevelled and β-catenin to Wnt target gene promoters independent of Wnt3A stimulation.

Authors:
Vaijayanti V Pethe George S Charames Bharati Bapat

Int J Oncol 2011 Oct 6;39(4):805-10. Epub 2011 Jun 6.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5T 3L9, Canada.

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http://dx.doi.org/10.3892/ijo.2011.1066DOI Listing
October 2011

Promoter methylation of Wnt antagonists DKK1 and SFRP1 is associated with opposing tumor subtypes in two large populations of colorectal cancer patients.

Authors:
James B Rawson Michael Manno Miralem Mrkonjic Darshana Daftary Elizabeth Dicks Daniel D Buchanan H Banfield Younghusband Patrick S Parfrey Joanne P Young Aaron Pollett Roger C Green Steven Gallinger John R McLaughlin Julia A Knight Bharati Bapat

Carcinogenesis 2011 May 8;32(5):741-7. Epub 2011 Feb 8.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/carcin/bgr020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140140PMC
May 2011

Quality assessment and correlation of microsatellite instability and immunohistochemical markers among population- and clinic-based colorectal tumors results from the Colon Cancer Family Registry.

Authors:
Mine S Cicek Noralane M Lindor Steven Gallinger Bharati Bapat John L Hopper Mark A Jenkins Joanne Young Daniel Buchanan Michael D Walsh Loic Le Marchand Terrilea Burnett Polly A Newcomb William M Grady Robert W Haile Graham Casey Sarah J Plummer Lisa A Krumroy John A Baron Stephen N Thibodeau

J Mol Diagn 2011 May;13(3):271-81

Division of Experimental Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.jmoldx.2010.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077724PMC
May 2011

Deciphering the colon cancer genes--report of the InSiGHT-Human Variome Project Workshop, UNESCO, Paris 2010.

Authors:
Maija R J Kohonen-Corish Finlay Macrae Maurizio Genuardi Stefan Aretz Bharati Bapat Inge T Bernstein John Burn Richard G H Cotton Johan T den Dunnen Thierry Frebourg Marc S Greenblatt Robert Hofstra Elke Holinski-Feder Ilkka Lappalainen Annika Lindblom Donna Maglott Pål Møller Hans Morreau Gabriela Möslein Rolf Sijmons Amanda B Spurdle Sean Tavtigian Carli M J Tops Thomas K Weber Niels de Wind Michael O Woods

Hum Mutat 2011 Apr 8;32(4):491-4. Epub 2011 Mar 8.

Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia.

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http://doi.wiley.com/10.1002/humu.21450
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http://dx.doi.org/10.1002/humu.21450DOI Listing
April 2011

Functional effects of the MLH1-93G>A polymorphism on MLH1/EPM2AIP1 promoter activity.

Authors:
Sheron Perera Miralem Mrkonjic James B Rawson Bharati Bapat

Oncol Rep 2011 Mar 30;25(3):809-15. Epub 2010 Dec 30.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 1 King's College Circle, Toronto, ON, Canada.

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http://dx.doi.org/10.3892/or.2010.1129DOI Listing
March 2011

A novel and rapid method of determining the effect of unclassified MLH1 genetic variants on differential allelic expression.

Authors:
Sheron Perera Brian Li Soultana Tsitsikotas Lily Ramyar Aaron Pollett Kara Semotiuk Bharati Bapat

J Mol Diagn 2010 Nov 23;12(6):757-64. Epub 2010 Sep 23.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.2353/jmoldx.2010.090240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963917PMC
November 2010

Specific variants in the MLH1 gene region may drive DNA methylation, loss of protein expression, and MSI-H colorectal cancer.

Authors:
Miralem Mrkonjic Nicole M Roslin Celia M Greenwood Stavroula Raptis Aaron Pollett Peter W Laird Vaijayanti V Pethe Theodore Chiang Darshana Daftary Elizabeth Dicks Stephen N Thibodeau Steven Gallinger Patrick S Parfrey H Banfield Younghusband John D Potter Thomas J Hudson John R McLaughlin Roger C Green Brent W Zanke Polly A Newcomb Andrew D Paterson Bharati Bapat

PLoS One 2010 Oct 13;5(10):e13314. Epub 2010 Oct 13.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013314PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954166PMC
October 2010

Epigenomics-based diagnostics.

Authors:
Eleftherios P Diamandis David Sidransky Peter W Laird Paul Cairns Bharati Bapat

Clin Chem 2010 Aug 14;56(8):1216-9. Epub 2010 May 14.

Department of Clinical Biochemistry, Mount Sinai Hospital and University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1373/clinchem.2010.148007DOI Listing
August 2010

Parent of origin effects on age at colorectal cancer diagnosis.

Authors:
Noralane M Lindor Kari G Rabe Gloria M Petersen Helen Chen Bharati Bapat John Hopper Joanne Young Mark Jenkins John Potter Polly Newcomb Allyson Templeton Loic Lemarchand John Grove Michael R Burgio Robert Haile Jane Green Michael O Woods Daniela Seminara Paul J Limburg Stephen N Thibodeau

Int J Cancer 2010 Jul;127(2):361-6

Department of Medical Genetics, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1002/ijc.25037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877160PMC
July 2010

DNA methylation of HOXD3 as a marker of prostate cancer progression.

Authors:
Ken J Kron Liyang Liu Vaijayanti V Pethe Nino Demetrashvili Michael E Nesbitt John Trachtenberg Hilmi Ozcelik Neil E Fleshner Laurent Briollais Theodorus H van der Kwast Bharati Bapat

Lab Invest 2010 Jul 8;90(7):1060-7. Epub 2010 Mar 8.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/labinvest.2010.57DOI Listing
July 2010

How to Deal with Batch Effect in Sequential Microarray Experiments?

Authors:
Nino Demetrashvili Ken Kron Vaijayanti Pethe Bharati Bapat Laurent Briollais

Mol Inform 2010 May 14;29(5):387-93. Epub 2010 May 14.

Dalla Lana School of Public Health, University of Toronto, Toronto M5T 3M7, Ontario Canada.

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http://dx.doi.org/10.1002/minf.200900019DOI Listing
May 2010

Lynch syndrome-associated breast cancers: clinicopathologic characteristics of a case series from the colon cancer family registry.

Authors:
Michael D Walsh Daniel D Buchanan Margaret C Cummings Sally-Ann Pearson Sven T Arnold Mark Clendenning Rhiannon Walters Diane M McKeone Amanda B Spurdle John L Hopper Mark A Jenkins Kerry D Phillips Graeme K Suthers Jill George Jack Goldblatt Amanda Muir Kathy Tucker Elise Pelzer Michael R Gattas Sonja Woodall Susan Parry Finlay A Macrae Robert W Haile John A Baron John D Potter Loic Le Marchand Bharati Bapat Stephen N Thibodeau Noralane M Lindor Michael A McGuckin Joanne P Young

Clin Cancer Res 2010 Apr 9;16(7):2214-24. Epub 2010 Mar 9.

Familial Cancer Laboratory, I Floor, Bancroft Centre, Queensland Institute of Medical Research, Herston Road, Herston, Queensland 4006, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-3058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848890PMC
April 2010

Alpha-1-antitrypsin deficiency and smoking as risk factors for mismatch repair deficient colorectal cancer: a study from the colon cancer family registry.

Authors:
Noralane M Lindor Ping Yang Ilonka Evans Karen Schowalter Mariza De Andrade Jia Li Elysia Jeavons Gloria Peterson Steve Gallinger Bharati Bapat John Hopper Jeremy Jass Mark Jenkins Allyson Templeton John Potter Polly A Newcomb Loic Lemarchand John Grove Robert Haile John Baron Daniela Seminara Paul Limburg Stephen N Thibodeau

Mol Genet Metab 2010 Feb 27;99(2):157-9. Epub 2009 Sep 27.

Department of Medical Genetics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.ymgme.2009.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818220PMC
February 2010

A novel complex mutation in MSH2 contributes to both Muir-Torre and Lynch Syndrome.

Authors:
Sheron Perera Lily Ramyar Angie Mitri Aaron Pollett Steven Gallinger Marsha D Speevak Melyssa Aronson Bharati Bapat

J Hum Genet 2010 Jan 13;55(1):37-41. Epub 2009 Nov 13.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/jhg.2009.119DOI Listing
January 2010

Predicting favourable prognosis of urothelial carcinoma: gene expression and genome profiling.

Authors:
Theodorus H van der Kwast Bharati Bapat

Curr Opin Urol 2009 Sep;19(5):516-21

Department of Pathology, University Health Network and University of Toronto, Canada.

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http://dx.doi.org/10.1097/MOU.0b013e32832eb45fDOI Listing
September 2009

High frequency of exon deletions and putative founder effects in French Canadian Lynch syndrome families.

Authors:
George Chong Jonathan Jarry Victoria Marcus Isabelle Thiffault Sebastian Winocour Yury Monczak Régen Drouin Jean Latreille Karlene Australie Bharati Bapat Philip H Gordon Yves Giguère Adrian Gologan Polymnia Galiatsatos Jeremy R Jass Nora Wong Sonya Zaor Laura Palma Lidia Kasprzak Marc Tischkowitz William D Foulkes

Hum Mutat 2009 Aug;30(8):E797-812

Departments of Medical Genetics and Oncology, Cancer Prevention Centre, Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada.

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http://dx.doi.org/10.1002/humu.21056DOI Listing
August 2009

Penetrance of colorectal cancer among MLH1/MSH2 carriers participating in the colorectal cancer familial registry in Ontario.

Authors:
Yun-Hee Choi Michelle Cotterchio Gail McKeown-Eyssen Monga Neerav Bharati Bapat Kevin Boyd Steven Gallinger John McLaughlin Melyssa Aronson Laurent Briollais

Hered Cancer Clin Pract 2009 Aug 23;7(1):14. Epub 2009 Aug 23.

Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Toronto, Canada.

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http://dx.doi.org/10.1186/1897-4287-7-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744657PMC
August 2009

Discovery of novel hypermethylated genes in prostate cancer using genomic CpG island microarrays.

Authors:
Ken Kron Vaijayanti Pethe Laurent Briollais Bekim Sadikovic Hilmi Ozcelik Alia Sunderji Vasundara Venkateswaran Jehonathan Pinthus Neil Fleshner Theodorus van der Kwast Bharati Bapat

PLoS One 2009 13;4(3):e4830. Epub 2009 Mar 13.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004830PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653233PMC
May 2009

Planning the human variome project: the Spain report.

Authors:
Jim Kaput Richard G H Cotton Lauren Hardman Michael Watson Aida I Al Aqeel Jumana Y Al-Aama Fahd Al-Mulla Santos Alonso Stefan Aretz Arleen D Auerbach Bharati Bapat Inge T Bernstein Jong Bhak Stacey L Bleoo Helmut Blöcker Steven E Brenner John Burn Mariona Bustamante Rita Calzone Anne Cambon-Thomsen Michele Cargill Paola Carrera Lawrence Cavedon Yoon Shin Cho Yeun-Jun Chung Mireille Claustres Garry Cutting Raymond Dalgleish Johan T den Dunnen Carlos Díaz Steven Dobrowolski M Rosário N dos Santos Rosemary Ekong Simon B Flanagan Paul Flicek Yoichi Furukawa Maurizio Genuardi Ho Ghang Maria V Golubenko Marc S Greenblatt Ada Hamosh John M Hancock Ross Hardison Terence M Harrison Robert Hoffmann Rania Horaitis Heather J Howard Carol Isaacson Barash Neskuts Izagirre Jongsun Jung Toshio Kojima Sandrine Laradi Yeon-Su Lee Jong-Young Lee Vera L Gil-da-Silva-Lopes Finlay A Macrae Donna Maglott Makia J Marafie Steven G E Marsh Yoichi Matsubara Ludwine M Messiaen Gabriela Möslein Mihai G Netea Melissa L Norton Peter J Oefner William S Oetting James C O'Leary Ana Maria Oller de Ramirez Mark H Paalman Jillian Parboosingh George P Patrinos Giuditta Perozzi Ian R Phillips Sue Povey Suyash Prasad Ming Qi David J Quin Rajkumar S Ramesar C Sue Richards Judith Savige Dagmar G Scheible Rodney J Scott Daniela Seminara Elizabeth A Shephard Rolf H Sijmons Timothy D Smith María-Jesús Sobrido Toshihiro Tanaka Sean V Tavtigian Graham R Taylor Jon Teague Thoralf Töpel Mollie Ullman-Cullere Joji Utsunomiya Henk J van Kranen Mauno Vihinen Elizabeth Webb Thomas K Weber Meredith Yeager Young I Yeom Seon-Hee Yim Hyang-Sook Yoo

Hum Mutat 2009 Apr;30(4):496-510

Division of Personalised Nutrition and Medicine, FDA/National Center for Toxicological Research, Jefferson, Arkansas 72079, USA.

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http://doi.wiley.com/10.1002/humu.20972
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http://dx.doi.org/10.1002/humu.20972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879779PMC
April 2009

The association of tumor microsatellite instability phenotype with family history of colorectal cancer.

Authors:
Bharati Bapat Noralane M Lindor John Baron Kim Siegmund Lin Li Yingye Zheng Robert Haile Steve Gallinger Jeremy R Jass Joanne P Young Michelle Cotterchio Mark Jenkins John Grove Graham Casey Stephen N Thibodeau D Timothy Bishop John L Hopper Dennis Ahnen Polly A Newcomb Loic Le Marchand John D Potter Daniela Seminara

Cancer Epidemiol Biomarkers Prev 2009 Mar 3;18(3):967-75. Epub 2009 Mar 3.

Department of Pathology and Lab Medicine, Mount Sinai Hospital, and Samuel Lunenfeld Research Institute, University of Toronto, 60 Murray Street, Box 30, Toronto, M5T 3L9, Ontario, Canada.

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http://dx.doi.org/10.1158/1055-9965.EPI-08-0878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763617PMC
March 2009

A large novel deletion in the APC promoter region causes gene silencing and leads to classical familial adenomatous polyposis in a Manitoba Mennonite kindred.

Authors:
George S Charames Lily Ramyar Angela Mitri Terri Berk Hong Cheng Jack Jung Patricia Bocangel Bernie Chodirker Cheryl Greenberg Elizabeth Spriggs Bharati Bapat

Hum Genet 2008 Dec 4;124(5):535-41. Epub 2008 Nov 4.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 60 Murray St., Toronto, Box 30, ON, M5T 3L9, Canada.

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http://link.springer.com/10.1007/s00439-008-0579-4
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http://dx.doi.org/10.1007/s00439-008-0579-4DOI Listing
December 2008

Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening.

Authors:
Jenny N Poynter Kimberly D Siegmund Daniel J Weisenberger Tiffany I Long Stephen N Thibodeau Noralane Lindor Joanne Young Mark A Jenkins John L Hopper John A Baron Dan Buchanan Graham Casey A Joan Levine Loïc Le Marchand Steven Gallinger Bharati Bapat John D Potter Polly A Newcomb Robert W Haile Peter W Laird

Cancer Epidemiol Biomarkers Prev 2008 Nov;17(11):3208-15

Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033-9176, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-08-0512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628332PMC
November 2008

Cyclin D1 Pro241Pro (CCND1-G870A) polymorphism is associated with increased cancer risk in human populations: a meta-analysis.

Authors:
Noel Pabalan Bharati Bapat Lillian Sung Hamdi Jarjanazi Ofelia Francisco-Pabalan Hilmi Ozcelik

Cancer Epidemiol Biomarkers Prev 2008 Oct;17(10):2773-81

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 60 Murray Street, Room L6-304, Box 29, Toronto, Ontario, Canada M5T 3L9.

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http://dx.doi.org/10.1158/1055-9965.EPI-08-0169DOI Listing
October 2008

Rac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells.

Authors:
Pinella Buongiorno Vaijayanti V Pethe George S Charames Susmita Esufali Bharati Bapat

Mol Cancer 2008 Sep 30;7:73. Epub 2008 Sep 30.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5T 3L9, Canada.

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http://dx.doi.org/10.1186/1476-4598-7-73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565678PMC
September 2008

Systemic Erdheim-Chester disease.

Authors:
Brendan Craig Dickson Vaijayanti Pethe Catherine Tse-Shing Chung David John Charles Howarth Juan Manuel Bilbao Victor Lodovico Fornasier Catherine Joanne Streutker Linda Marilyn Sugar Bharati Bapat

Virchows Arch 2008 Feb 10;452(2):221-7. Epub 2008 Jan 10.

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00428-007-0538-9DOI Listing
February 2008

The MLH1 variants p.Arg265Cys and p.Lys618Ala affect protein stability while p.Leu749Gln affects heterodimer formation.

Authors:
Sheron Perera Bharati Bapat

Hum Mutat 2008 Feb;29(2):332

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1002/humu.9523DOI Listing
February 2008

MSH2 118T>C and MSH6 159C>T promoter polymorphisms and the risk of colorectal cancer.

Authors:
Miralem Mrkonjic Stavroula Raptis Roger C Green Neerav Monga Darshana Daftary Elizabeth Dicks H Banfield Younghusband Patrick S Parfrey Steven S Gallinger John R McLaughlin Julia A Knight Bharati Bapat

Carcinogenesis 2007 Dec 17;28(12):2575-80. Epub 2007 Oct 17.

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada.

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http://dx.doi.org/10.1093/carcin/bgm229DOI Listing
December 2007

Suppression of nuclear Wnt signaling leads to stabilization of Rac1 isoforms.

Authors:
Susmita Esufali George S Charames Bharati Bapat

FEBS Lett 2007 Oct 17;581(25):4850-6. Epub 2007 Sep 17.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 60 Murray Street, Room L6-304-4, Toronto, Canada.

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http://dx.doi.org/10.1016/j.febslet.2007.09.013DOI Listing
October 2007

Does early colectomy increase desmoid risk in familial adenomatous polyposis?

Authors:
Carol Durno Neerav Monga Bharati Bapat Theresa Berk Zane Cohen Steven Gallinger

Clin Gastroenterol Hepatol 2007 Oct;5(10):1190-4

Familial Gastrointestinal Cancer Registry and Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cgh.2007.06.010DOI Listing
October 2007

An association between the 4G polymorphism in the PAI-1 promoter and the development of aggressive fibromatosis (desmoid tumor) in familial adenomatous polyposis patients.

Authors:
Catherine F Li Robert Y Wei Frank Baliko Bharati Bapat Benjamin A Alman

Fam Cancer 2007 ;6(1):89-95

Program in Developmental Biology, The Hospital for Sick Children, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1007/s10689-006-9109-5DOI Listing
September 2007

MYH mutations are rare in prostate cancer.

Authors:
Eyun-Jung Shin Edward Chappell Vaijayanti Pethe Karen Hersey Theodore van der Kwast Neil Fleshner Bharati Bapat

J Cancer Res Clin Oncol 2007 Jun 12;133(6):373-8. Epub 2007 Jan 12.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00432-006-0181-xDOI Listing
June 2007

Germline MYH mutations in a clinic-based series of Canadian multiple colorectal adenoma patients.

Authors:
Marina E Croitoru Sean P Cleary Terri Berk Nando Di Nicola Ilana Kopolovic Bharati Bapat Steven Gallinger

J Surg Oncol 2007 May;95(6):499-506

Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/jso.20724DOI Listing
May 2007

Activation of tumor-specific splice variant Rac1b by dishevelled promotes canonical Wnt signaling and decreased adhesion of colorectal cancer cells.

Authors:
Susmita Esufali George S Charames Vaijayanti V Pethe Pinella Buongiorno Bharati Bapat

Cancer Res 2007 Mar;67(6):2469-79

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-2843DOI Listing
March 2007

MLH1 -93G>A promoter polymorphism and the risk of microsatellite-unstable colorectal cancer.

Authors:
Stavroula Raptis Miralem Mrkonjic Roger C Green Vaijayanti V Pethe Neerav Monga Yuen Man Chan Darshana Daftary Elizabeth Dicks Banfield H Younghusband Patrick S Parfrey Steven S Gallinger John R McLaughlin Julia A Knight Bharati Bapat

J Natl Cancer Inst 2007 Mar;99(6):463-74

Department of Pathology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5T 3L9.

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http://dx.doi.org/10.1093/jnci/djk095DOI Listing
March 2007

Ascending the learning curve--MSI testing experience of a six-laboratory consortium.

Authors:
Noralane M Lindor Regenia Smalley Melissa Barker Jeannette Bigler Lisa M Krumroy Annette Lum-Jones Sarah J Plummer Teresa Selander Sushma Thomas Michelle Youash Daniela Seminara Graham Casey Bharati Bapat Stephen N Thibodeau

Cancer Biomark 2006 ;2(1-2):5-9

Department of Medical Genetics, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.3233/cbm-2006-21-202DOI Listing
February 2007

Rho GTPases and cancer.

Authors:
Pinella Buongiorno Bharati Bapat

Prog Mol Subcell Biol 2005 ;40:29-53

Samuel Lunenfeld Research Institute, 9th Floor, Room 992B, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5 Canada.

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http://dx.doi.org/10.1007/3-540-27671-8_2DOI Listing
January 2007

Peutz-Jeghers syndrome diagnosed in a schizophrenic patient with a large deletion in the STK11 gene.

Authors:
Michael Kam Jorge Massare Steven Gallinger Joseph Kinzie Donald Weaver John D Dingell Susmita Esufali Bharati Bapat Martin Tobi

Dig Dis Sci 2006 Sep 22;51(9):1567-70. Epub 2006 Aug 22.

VAMC, Department of Medicine, Division of Gastroenterology and Surgery, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.

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http://dx.doi.org/10.1007/s10620-006-9102-8DOI Listing
September 2006

Genetic instability in human tumors.

Authors:
Stavroula Raptis Bharati Bapat

EXS 2006 (96):303-20

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5 Canada.

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http://dx.doi.org/10.1007/3-7643-7378-4_13DOI Listing
February 2006

Cyclooxygenase-2 knockdown by RNA interference in colon cancer.

Authors:
George S Charames Bharati Bapat

Int J Oncol 2006 Feb;28(2):543-9

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada.

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February 2006

High frequency of hereditary colorectal cancer in Newfoundland likely involves novel susceptibility genes.

Authors:
Michael O Woods Angela J Hyde Fiona K Curtis Susan Stuckless Jane S Green Aaron F Pollett J Desmond Robb Roger C Green Marina E Croitoru Amanda Careen Jason A W Chaulk Jegan Jegathesan John R McLaughlin Steven S Gallinger H Banfield Younghusband Bharati V Bapat Patrick S Parfrey

Clin Cancer Res 2005 Oct;11(19 Pt 1):6853-61

Discipline of Genetics, Department of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-0726DOI Listing
October 2005

Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X.

Authors:
Noralane M Lindor Kari Rabe Gloria M Petersen Robert Haile Graham Casey John Baron Steve Gallinger Bharati Bapat Melyssa Aronson John Hopper Jeremy Jass Loic LeMarchand John Grove John Potter Polly Newcomb Jonathan P Terdiman Peggy Conrad Gabriella Moslein Richard Goldberg Argyrios Ziogas Hoda Anton-Culver Mariza de Andrade Kim Siegmund Stephen N Thibodeau Lisa A Boardman Daniela Seminara

JAMA 2005 Apr;293(16):1979-85

Department of Medical Genetics, Mayo Clinic, Rochester, Minn, USA.

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.29
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http://dx.doi.org/10.1001/jama.293.16.1979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933042PMC
April 2005

Conversion analysis for mutation detection in MLH1 and MSH2 in patients with colorectal cancer.

Authors:
Graham Casey Noralane M Lindor Nickolas Papadopoulos Stephen N Thibodeau John Moskow Scott Steelman Carolyn H Buzin Steve S Sommer Christine E Collins Malinda Butz Melyssa Aronson Steven Gallinger Melissa A Barker Joanne P Young Jeremy R Jass John L Hopper Anh Diep Bharati Bapat Michael Salem Daniela Seminara Robert Haile

JAMA 2005 Feb;293(7):799-809

Department of Cancer Biology, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1001/jama.293.7.799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933041PMC
February 2005

Apoptotic and growth regulatory genes as mutational targets in mismatch repair deficient endometrioid adenocarcinomas of young patients.

Authors:
Vessela Vassileva Anna Millar Laurent Briollais William Chapman Bharati Bapat

Oncol Rep 2004 Apr;11(4):931-7

Samuel Lunenfeld Research Institute, Toronto, Canada.

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April 2004

Genotype and phenotype of patients with both familial adenomatous polyposis and thyroid carcinoma.

Authors:
Brindusa Truta Brian A Allen Peggy G Conrad Young S Kim Terri Berk Steven Gallinger Bharati Bapat Jonathan P Terdiman Marvin H Sleisenger

Fam Cancer 2003 ;2(2):95-9

University California San Francisco, Department of Medicine, Comprehensive Cancer Center, San Francisco, California, USA.

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http://dx.doi.org/10.1023/a:1025762706854DOI Listing
January 2004

Genomic instability and cancer.

Authors:
George S Charames Bharati Bapat

Curr Mol Med 2003 Nov;3(7):589-96

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada.

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http://dx.doi.org/10.2174/1566524033479456DOI Listing
November 2003

Hereditary nonpolyposis colorectal cancer--molecular basis.

Authors:
Christine Brezden-Masley Melyssa D Aronson Bharati Bapat Aaron Pollett Robert Gryfe Mark Redston Steven Gallinger

Surgery 2003 Jul;134(1):29-33

Department of Surgery, Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1067/msy.2003.176DOI Listing
July 2003

Methylation of adenomatous polyposis coli in endometrial cancer occurs more frequently in tumors with microsatellite instability phenotype.

Authors:
Michele Zysman Asantha Saka Anna Millar Julia Knight William Chapman Bharati Bapat

Cancer Res 2002 Jul;62(13):3663-6

Samuel Lunenfeld Research Institute, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.

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July 2002

Genes involved in DNA repair are mutational targets in endometrial cancers with microsatellite instability.

Authors:
Vessela Vassileva Anna Millar Laurent Briollais William Chapman Bharati Bapat

Cancer Res 2002 Jul;62(14):4095-9

Samuel Lunenfeld Research Institute, Toronto, Ontario, M5G 1X5 Canada.

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July 2002

Considerations when analyzing the methylation status of PTEN tumor suppressor gene.

Authors:
Michele A Zysman William B Chapman Bharati Bapat

Am J Pathol 2002 Mar;160(3):795-800

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867163PMC
http://dx.doi.org/10.1016/S0002-9440(10)64902-4DOI Listing
March 2002

Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors.

Authors:
Noralane M Lindor Lawrence J Burgart Olga Leontovich Richard M Goldberg Julie M Cunningham Daniel J Sargent Catherine Walsh-Vockley Gloria M Petersen Michael D Walsh Barbara A Leggett Joanne P Young Melissa A Barker Jeremy R Jass John Hopper Steve Gallinger Bharati Bapat Mark Redston Stephen N Thibodeau

J Clin Oncol 2002 Feb;20(4):1043-8

Department of Medical Genetics, Mayo Foundation, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1200/JCO.2002.20.4.1043DOI Listing
February 2002