Bhagwat Prasad

Bhagwat Prasad

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Bhagwat Prasad

Bhagwat Prasad

Publications by authors named "Bhagwat Prasad"

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71Publications

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Normalized testosterone glucuronide (TG/AG) as a potential urinary biomarker for highly variable UGT2B17 in children 7 to 18 years.

Clin Pharmacol Ther 2020 Jan 3. Epub 2020 Jan 3.

Department of Pharmaceutics, University of Washington, Seattle, WA, USA, 98195.

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http://dx.doi.org/10.1002/cpt.1764DOI Listing
January 2020

Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism.

Drug Metab Dispos 2019 08 17;47(8):818-831. Epub 2019 May 17.

Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Mohali, Punjab, India (M.K.L., S.Sh., A.T., S.Si.); Department of Pharmaceutics, University of Washington, Seattle, Washington (D.K.B., B.P.); Division of Clinical Pharmacology, Toxicology & Therapeutic Innovation, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri (A.G., R.E.P., J.S.L.); School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri (A.G., R.E.P., J.S.L.); and Simulations Plus, Inc., Lancaster, California (M.B.B.)

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http://dmd.aspetjournals.org/lookup/doi/10.1124/dmd.119.0864
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http://dx.doi.org/10.1124/dmd.119.086462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614793PMC
August 2019

Kidney Cortical Transporter Expression across Species Using Quantitative Proteomics.

Drug Metab Dispos 2019 08 23;47(8):802-808. Epub 2019 May 23.

Department of Pharmaceutics, University of Washington, Seattle, Washington (A.B., M.K., B.P.); and Pfizer Worldwide Research Development, Drug Safety Research Development, Cambridge, Massachusetts (Z.R., V.S.V.)

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http://dx.doi.org/10.1124/dmd.119.086579DOI Listing
August 2019

Major glucuronide metabolites of testosterone are primarily transported by MRP2 and MRP3 in human liver, intestine and kidney.

J Steroid Biochem Mol Biol 2019 07 5;191:105350. Epub 2019 Apr 5.

Department of Pharmaceutics, University of Washington, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2019.03.027DOI Listing
July 2019

Quantitative Proteomics Reveals Changes in Transporter Protein Abundance in Liver, Kidney and Brain of Mice by Pregnancy.

Drug Metab Lett 2018 ;12(2):145-152

Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington DC, 98195, United States.

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http://dx.doi.org/10.2174/1872312812666180625122810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350206PMC
June 2019

Physiologically Relevant, Humanized Intestinal Systems to Study Metabolism and Transport of Small Molecule Therapeutics.

Drug Metab Dispos 2018 11 20;46(11):1581-1587. Epub 2018 Aug 20.

Pfizer Worldwide Research & Development, Clinical Pharmacology, 1 Portland Street, Cambridge, MA 02139 (A.S.-B.); Pfizer Worldwide Research & Development, PDM, Eastern Point Road, Groton, 06340 (A.D.R.); Pfizer Worldwide Research & Development, Inflammation and Immunology, 1 Portland Street, Cambridge, MA 02139 (M.L., M.K.); Pfizer Worldwide Research & Development, Discovery Sciences, Eastern Point Road, Groton, 06340 (R.D.); Assistant Professor, Department of Pharmaceutics, UWRAPT H268, Health Science Building, Seattle (B.P.); Pfizer Worldwide Research & Development, Early Clinical Development, Clinical Pharmacology, 1 Portland Street, Cambridge, MA 02139 (N.T.).

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http://dmd.aspetjournals.org/lookup/doi/10.1124/dmd.118.0827
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http://dx.doi.org/10.1124/dmd.118.082784DOI Listing
November 2018

The Importance of Incorporating OCT2 Plasma Membrane Expression and Membrane Potential in IVIVE of Metformin Renal Secretory Clearance.

Drug Metab Dispos 2018 10 9;46(10):1441-1445. Epub 2018 Aug 9.

Department of Pharmaceutics, University of Washington, Seattle, Washington (V.K., J.Y., B.P., J.W., J.D.U.) and Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom (S.B., C.D.A.B.)

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http://dx.doi.org/10.1124/dmd.118.082313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130461PMC
October 2018

Effect of Dose and 5α-Reductase Inhibition on the Circulating Testosterone Metabolite Profile of Men Administered Oral Testosterone.

Clin Transl Sci 2018 09 19;11(5):513-522. Epub 2018 Jun 19.

Department of Pharmaceutics, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1111/cts.12569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132360PMC
September 2018

PBDEs Altered Gut Microbiome and Bile Acid Homeostasis in Male C57BL/6 Mice.

Drug Metab Dispos 2018 08 16;46(8):1226-1240. Epub 2018 May 16.

Departments of Environmental and Occupational Health Sciences (C.Y.F., J.L.D., S.L., K.M.W., J.Y.C.) and Pharmaceutics (D.K.B., B.P.) and Northwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine (D.W., Q.F., D.R.), University of Washington, Seattle, Washington; Arizona Metabolomics Laboratory, Center for Metabolic and Vascular Biology, School of Nutrition and Health Promotion, College of Health Solutions, Arizona State University, Phoenix, Arizona (H.G.); Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, P. R. China (D.W.); and Department of Chemistry, Jilin University, Changchun, Jilin Province, P. R. China (Q.F.)

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http://dx.doi.org/10.1124/dmd.118.081547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053593PMC
August 2018

Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study.

Drug Metab Dispos 2018 07 25;46(7):943-952. Epub 2018 Apr 25.

University of Washington, Seattle, Washington (B.P., D.K.B., K.J., R.C., J.D.U.); Merck Sharp & Dohme Corporation, Kenilworth, New Jersey (X.C.); Gilead Sciences, Inc., Foster City, California (A.S.R., A.M.); Genentech, South San Francisco, California (L.S., C.E.C.A.H.); Biogen, Cambridge, Massachusetts (G.X.); Ardea Biosciences, Inc., San Diego, California (C.L.); Bristol-Myers Squibb Company, Princeton, New Jersey (Y.L., W.H.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (M.L.); and University of Kansas Medical Center, Kansas City, Kansas (S.C.K.)

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http://dx.doi.org/10.1124/dmd.118.080523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987995PMC
July 2018

Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity.

Mol Pharmacol 2018 07 2;94(1):689-699. Epub 2018 May 2.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California (L.Z., A.S., H.-C.C., S.W.Y., K.M.G.); Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (A.G.); Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (B.P., L.W., J.D.U.); and Safety and ADME Translational Sciences, Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Cambridge, UK (S.H.S., K.S.F.)

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http://molpharm.aspetjournals.org/lookup/doi/10.1124/mol.117
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http://dx.doi.org/10.1124/mol.117.111153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987998PMC
July 2018

Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.

Drug Metab Dispos 2018 06 30;46(6):888-896. Epub 2018 Mar 30.

Departments of Pharmaceutics (D.K.B., A.B., H.Z., K.G.C., A.M., B.P.), Genome Sciences (S.L., D.A.N.), Biostatistics (T.A.T.), and Medicine (J.K.A.), University of Washington, Seattle, Washington; Division of Pediatric Pharmacology and Medical Toxicology, Department of Pediatrics, Children's Mercy Hospitals and Clinics, Kansas City, Missouri (A.G., R.E.P., R.G., J.S.L.); Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.C., E.G.S.); and Section of Genomic Pediatrics, Department of Pediatrics, and Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin (U.B.)

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http://dx.doi.org/10.1124/dmd.118.080952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938891PMC
June 2018

Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D-3--Sulfate, a Major Circulating Vitamin D Metabolite in Humans.

Drug Metab Dispos 2018 04 17;46(4):367-379. Epub 2018 Jan 17.

Departments of Pharmaceutics (T.W., Z.W., B.D.C., M.S., K.G.C., C.G., B.P., Al.C., J.C., Q.M., K.E.T.), Medicine and Kidney Research Institute (I.H.d.B.), and Biostatistics (T.A.T.), University of Washington, Seattle, Washington; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California (Z.W.); Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (R.S.F.); St. Jude Children's Research Hospital, Memphis, Tennessee (Am.C., E.G.S.); and Heartland Assays LLC, Ames, Iowa (R.L.H.)

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http://dx.doi.org/10.1124/dmd.117.078428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829543PMC
April 2018

Ten Years' Experience with the CYP2D6 Activity Score: A Perspective on Future Investigations to Improve Clinical Predictions for Precision Therapeutics.

J Pers Med 2018 Apr 17;8(2). Epub 2018 Apr 17.

Division of Clinical Pharmacology, Toxicology & Therapeutic Innovation, Children's Mercy Kansas City, 2401 Gillham Rd, Kanas City, MO 64108, USA.

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http://dx.doi.org/10.3390/jpm8020015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023391PMC
April 2018

Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics.

Drug Metab Dispos 2018 02 14;46(2):189-196. Epub 2017 Nov 14.

Department of Pharmaceutics, University of Washington, Seattle, Washington (S.B., E.J.K., B.P., J.D.U.); Departments of Clinical Research, Clinical Pharmacology, and Drug Metabolism and Pharmacokinetics, Gilead Sciences, Inc., Foster City, California (A.S.R., A.M., Y.L.); Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California (L.S., C.E.C.A.H.); DMPK, Biogen Idec, Cambridge, Massachusetts (G.X., C.R.); Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Rahway, New Jersey (X.C., R.E.); Bristol-Myers Squibb Company, Princeton, New Jersey (W.G.H.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (M.L.); and Translational Sciences, Ardea Biosciences, Inc., San Diego, California (C.A.L.)

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http://dx.doi.org/10.1124/dmd.117.077289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776333PMC
February 2018

Pregnancy Increases Norbuprenorphine Clearance in Mice by Induction of Hepatic Glucuronidation.

Drug Metab Dispos 2018 02 20;46(2):100-108. Epub 2017 Nov 20.

Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington

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http://dx.doi.org/10.1124/dmd.117.076745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765905PMC
February 2018

Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver.

J Pharmacol Exp Ther 2017 11 17;363(2):265-274. Epub 2017 Aug 17.

Departments of Pharmaceutics (M.X., D.K.B., K.G.C., K.E.T., B.P.), Medicinal Chemistry (C.K.Y., A.E.R.), and Genome Sciences (D.N.), University of Washington, Seattle, Washington; Department of Clinical Pharmacology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China (M.X.); Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.C., E.S.); Division of Pediatric Pharmacology and Medical Toxicology, Department of Pediatrics, Children's Mercy Hospitals and Clinics, Kansas City, Missouri (A.G., R.E.P., R.G., J.S.L.); and Section of Genomic Pediatrics, Department of Pediatrics, and Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin (U.B.)

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http://jpet.aspetjournals.org/lookup/doi/10.1124/jpet.117.24
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http://dx.doi.org/10.1124/jpet.117.243113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697103PMC
November 2017

Novel Interactions between Gut Microbiome and Host Drug-Processing Genes Modify the Hepatic Metabolism of the Environmental Chemicals Polybrominated Diphenyl Ethers.

Drug Metab Dispos 2017 11 1;45(11):1197-1214. Epub 2017 Sep 1.

Department of Environmental and Occupational Health Sciences (C.Y.L., S.L., T.K.B., J.Y.C.), and Department of Pharmaceutics (D.K.B., B.P.), University of Washington, Seattle, Washington; and Pacific Northwest National Laboratory, Sequim, Washington (S.C., L.-J.K., I.R.S.)

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http://dx.doi.org/10.1124/dmd.117.077024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649562PMC
November 2017

Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver.

Drug Metab Dispos 2017 09 12;45(9):1044-1048. Epub 2017 Jun 12.

Department of Pharmaceutics, University of Washington, Seattle, Washington (D.K.B., B.P.); Department of Clinical Pharmacology, Toxicology & Therapeutic Innovation, Children's Mercy-Kansas City, Missouri and School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri (A.G., R.E.P., J.S.L.)

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http://dx.doi.org/10.1124/dmd.117.076463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563927PMC
September 2017

P-gp/ABCB1 exerts differential impacts on brain and fetal exposure to norbuprenorphine.

Pharmacol Res 2017 05 19;119:61-71. Epub 2017 Jan 19.

Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2017.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392442PMC
May 2017

The Promises of Quantitative Proteomics in Precision Medicine.

J Pharm Sci 2017 03 8;106(3):738-744. Epub 2016 Dec 8.

Department of Pharmaceutics, University of Washington, Seattle, P.O. Box 357610, Washington 98195.

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http://dx.doi.org/10.1016/j.xphs.2016.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313344PMC
March 2017

Harnessing Solute Carrier Transporters for Precision Oncology.

Molecules 2017 Mar 28;22(4). Epub 2017 Mar 28.

Division of Oncology, Department of Medicine, University of Washington, Seattle, WA 98195 USA.

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http://dx.doi.org/10.3390/molecules22040539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570559PMC
March 2017

Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants.

Drug Metab Dispos 2017 02 28;45(2):216-223. Epub 2016 Nov 28.

Department of Pharmaceutics, University of Washington, Seattle, Washington (M.B., M.V., A.M., D.K.B., B.P.); Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden (M.B.); Division of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy Kansas City, Kansas City, Missouri (R.E.P., A.G., J.S.L.); and School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri (R.E.P., A.G., J.S.L.)

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http://dx.doi.org/10.1124/dmd.116.072652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267516PMC
February 2017

Predictors of Variation in CYP2A6 mRNA, Protein, and Enzyme Activity in a Human Liver Bank: Influence of Genetic and Nongenetic Factors.

J Pharmacol Exp Ther 2017 Jan 4;360(1):129-139. Epub 2016 Nov 4.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada (J-A.T., R.F.T.); Department of Pharmacology and Toxicology (J-A.T., R.F.T.) and Department of Psychiatry (R.F.T.), University of Toronto, Toronto, Ontario, Canada; Department of Pharmaceutics (B.P., K.G.C, K.E.T.) and Center for Exposures, Diseases, Genomics, and Environment (P.S.), University of Washington, Seattle, Washington; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.C., E.G.S.)

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http://dx.doi.org/10.1124/jpet.116.237594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193072PMC
January 2017

Abundance of Drug Transporters in the Human Kidney Cortex as Quantified by Quantitative Targeted Proteomics.

Drug Metab Dispos 2016 12 12;44(12):1920-1924. Epub 2016 Sep 12.

Department of Pharmaceutics, University of Washington, Seattle, Washington (B.P., K.J., S.B., E.J.K., J.D.U.); Ardea Biosciences, San Diego, California (C.L.); Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom (G.W.C., C.D.A.B); and Division of Nephrology, Kidney Research Institute, University of Washington, Seattle, Washington (J.H.).

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http://dx.doi.org/10.1124/dmd.116.072066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118637PMC
December 2016

An Optimized Method for Protein Extraction from OCT-Embedded Human Kidney Tissue for Protein Quantification by LC-MS/MS Proteomics.

Drug Metab Dispos 2016 10 1;44(10):1692-6. Epub 2016 Aug 1.

Department of Pharmaceutics (M.V., B.P.) and Kidney Research Institute and Division of Nephrology, Department of Medicine (A.G., M.A.), University of Washington, Seattle, Washington

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034699PMC
http://dx.doi.org/10.1124/dmd.116.071522DOI Listing
October 2016

Interindividual Variability in Cytochrome P450-Mediated Drug Metabolism.

Drug Metab Dispos 2016 Mar 17;44(3):343-51. Epub 2015 Dec 17.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.S.T.); Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.C., E.G.S.); Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (B.P., K.E.T., L.M.S., J.T.-S., Y.S.L.); Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut (X.Z., Y.-C.T); and Departments of Pharmacy Practice and Biopharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago, Illinois (H.J., X.P.).

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http://dx.doi.org/10.1124/dmd.115.067900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767386PMC
March 2016

Atenolol Renal Secretion Is Mediated by Human Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Proteins.

Drug Metab Dispos 2015 Dec 15;43(12):1872-81. Epub 2015 Sep 15.

Department of Pharmaceutics, University of Washington, Seattle, Washington

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http://dx.doi.org/10.1124/dmd.115.066175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658496PMC
December 2015

Developmental Regulation of Drug-Processing Genes in Livers of Germ-Free Mice.

Toxicol Sci 2015 Sep 1;147(1):84-103. Epub 2015 Jun 1.

*Department of Environmental & Occupational Health Sciences and

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http://dx.doi.org/10.1093/toxsci/kfv110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560037PMC
September 2015

The CYP2C19 Intron 2 Branch Point SNP is the Ancestral Polymorphism Contributing to the Poor Metabolizer Phenotype in Livers with CYP2C19*35 and CYP2C19*2 Alleles.

Drug Metab Dispos 2015 Aug 28;43(8):1226-35. Epub 2015 May 28.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.C., E.G.S.); Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (B.P., Y.S., A.F., K.E.T.); Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee (D.F., Y.F., S.W., G.W.); Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden (E.A.); and Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (S.C.S.)

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.115.064428
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http://dx.doi.org/10.1124/dmd.115.064428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518065PMC
August 2015

Solute Carrier Family of the Organic Anion-Transporting Polypeptides 1A2- Madin-Darby Canine Kidney II: A Promising In Vitro System to Understand the Role of Organic Anion-Transporting Polypeptide 1A2 in Blood-Brain Barrier Drug Penetration.

Drug Metab Dispos 2015 Jul 23;43(7):1008-18. Epub 2015 Apr 23.

Drug Metabolism and Pharmacokinetics (H.L., N.Y., S.L., X.L., Y.L., F.W., J.S.) and Molecular Discovery Research (H.X., G.A.), Platform Technology and Science, GlaxoSmithKline Research and Development, Shanghai, China; Modelling and Translational Biology, Platform Technology and Science, GlaxoSmithKline, Ware, United Kingdom (E.H.); Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, University Of Tokyo, Tokyo, Japan (S.I., X.Z., H.K.); Sugiyama Laboratory, RIKEN Innovation Center, Research Cluster for Innovation, RIKEN, Kanagawa, Japan (Y.S.); and Department of Pharmaceutics, University of Washington, Seattle, Washington (B.P., J.D.U.)

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http://dx.doi.org/10.1124/dmd.115.064170DOI Listing
July 2015

Prediction of gestational age-dependent induction of in vivo hepatic CYP3A activity based on HepaRG cells and human hepatocytes.

Drug Metab Dispos 2015 Jun 23;43(6):836-42. Epub 2015 Mar 23.

Department of Pharmaceutics, University of Washington, Seattle, Washington (Z.Z., M.F., B.P., J.D.U.); and Life Technologies, Carlsbad, California (S.G.)

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.114.062984
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http://dx.doi.org/10.1124/dmd.114.062984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429679PMC
June 2015

Interspecies variability in expression of hepatobiliary transporters across human, dog, monkey, and rat as determined by quantitative proteomics.

Drug Metab Dispos 2015 Mar 22;43(3):367-74. Epub 2014 Dec 22.

Department of Pharmaceutics, University of Washington, Seattle, Washington (L.W., B.P., J.D.U.); Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California (L.S., C.E.C.A.H.); Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Rahway, New Jersey (X.C.); Drug Metabolism and Pharmacokinetics, Infection DMPK, AstraZeneca Pharmaceuticals LLP, Waltham, Massachusetts (A.G.); and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Kenilworth, New Jersey (R.E.)

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http://dx.doi.org/10.1124/dmd.114.061580DOI Listing
March 2015

Quantitative transporter proteomics by liquid chromatography with tandem mass spectrometry: addressing methodologic issues of plasma membrane isolation and expression-activity relationship.

Drug Metab Dispos 2015 Feb 8;43(2):284-8. Epub 2014 Dec 8.

Department of Pharmaceutics, University of Washington, Seattle, Washington (V.K., B.P., G.P., J.D.U.); Drug Metabolism and Pharmacokinetics, Infection Innovative Medicines Unit, AstraZeneca Pharmaceuticals LLP, Waltham, Massachusetts (A.G.); Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Kenilworth, New Jersey (R.E.); Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, Californai (L.S., C.E.C.A.H.)

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http://dx.doi.org/10.1124/dmd.114.061614DOI Listing
February 2015

Importance of ALDH1A enzymes in determining human testicular retinoic acid concentrations.

J Lipid Res 2015 Feb 11;56(2):342-57. Epub 2014 Dec 11.

Department of Pharmaceutics, School of Pharmacy, School of Medicine, University of Washington, Seattle, WA 98195.

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http://dx.doi.org/10.1194/jlr.M054718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306688PMC
February 2015

Role of (drug) transporters in imaging in health and disease.

Drug Metab Dispos 2014 Dec 23;42(12):2007-15. Epub 2014 Sep 23.

Department of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland (B.S.); Department of Pharmaceutics, University of Washington, Seattle, Washington (J.D.U., B.P.); Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria and Health and Environment Department, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria (O.L.); and the Department of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma (H.G.).

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http://dx.doi.org/10.1124/dmd.114.059873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611776PMC
December 2014

Identification of CYP3A7 for glyburide metabolism in human fetal livers.

Biochem Pharmacol 2014 Dec 22;92(4):690-700. Epub 2014 Oct 22.

Department of Pharmaceutics, School of Pharmacy, University of Washington, Box 357610, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2014.09.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314379PMC
December 2014

Protein abundance of clinically relevant multidrug transporters along the entire length of the human intestine.

Mol Pharm 2014 Oct 11;11(10):3547-55. Epub 2014 Sep 11.

Department of Experimental and Clinical Pharmacology, Pomeranian Medical University , Szczecin, Poland.

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http://dx.doi.org/10.1021/mp500330yDOI Listing
October 2014

Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins.

Drug Metab Dispos 2014 Aug 22;42(8):1301-13. Epub 2014 May 22.

DMPK and Bioanalytical Research, Abbvie Deutschland GmbH & Co. KG, Ludwigshafen, Germany (M.M., L.L., R.A.B.v.W.); Metabolism and Pharmacokinetics, Bristol-Myers Squibb, Wallingford, Connecticut (M.G.S.); Genentech, Inc., South San Francisco, California (L.S., E.G.G., J.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline Pharmaceuticals, King of Prussia, Pennsylvania (L.C., D.M.-F., J.Ke.); Janssen Research and Development, LLC, Spring House, Pennsylvania (S.D., J.Ku.); Merck Sharp & Dohme Corporation, Whitehouse Station, New Jersey (X.C., R.E., J.Y., R.E.); Department of Pharmaceutics, University of Washington, Seattle, Washington (B.P., J.D.U.); Division of Molecular Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands (A.H.S.); and TaconicArtemis, Koeln, Germany (A.R., N.S.)

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August 2014

PET imaging of Oatp-mediated hepatobiliary transport of [(11)C] rosuvastatin in the rat.

Mol Pharm 2014 Aug 8;11(8):2745-54. Epub 2014 Jul 8.

Department of Pharmaceutics, University of Washington , Seattle, Washington 98195, United States.

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http://dx.doi.org/10.1021/mp500027cDOI Listing
August 2014

Mechanism of an unusual, but clinically significant, digoxin-bupropion drug interaction.

Biopharm Drug Dispos 2014 Jul 3;35(5):253-63. Epub 2014 Mar 3.

Department of Pharmaceutics, University of Washington, Seattle, Washington, 98195, USA; Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, 210009, P.R. China.

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http://dx.doi.org/10.1002/bdd.1890DOI Listing
July 2014

Optimized approaches for quantification of drug transporters in tissues and cells by MRM proteomics.

AAPS J 2014 Jul 22;16(4):634-48. Epub 2014 Apr 22.

Department of Pharmaceutics, University of Washington, P.O. Box 357610, Seattle, Washington, 98195, USA,

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http://dx.doi.org/10.1208/s12248-014-9602-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070263PMC
July 2014

Comparison of Heavy Labeled (SIL) Peptide versus SILAC Protein Internal Standards for LC-MS/MS Quantification of Hepatic Drug Transporters.

Int J Proteomics 2014 25;2014:451510. Epub 2014 Feb 25.

Department of Pharmaceutics, University of Washington, P.O. Box 357610, Seattle, WA 98195, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955635PMC
April 2014

Interindividual variability in hepatic organic anion-transporting polypeptides and P-glycoprotein (ABCB1) protein expression: quantification by liquid chromatography tandem mass spectroscopy and influence of genotype, age, and sex.

Drug Metab Dispos 2014 Jan 11;42(1):78-88. Epub 2013 Oct 11.

Department of Pharmaceutics, University of Washington, Seattle, Washington (B.P., J.D.U.); Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Rahway, New Jersey (R.E.); Drug Metabolism and Pharmacokinetics, Infection DMPK, AstraZeneca Pharmaceuticals LLP, Waltham, Massachusetts (A.G.); Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California (C.E.H., L.S.); Laboratory of Cell Biology, Center for Cancer Research, National Institutes of Health National Cancer Institute, Bethesda, Maryland (S.S., S.V.A.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876790PMC
January 2014

Effect of gestational age on mRNA and protein expression of polyspecific organic cation transporters during pregnancy.

Drug Metab Dispos 2013 Dec 7;41(12):2225-32. Epub 2013 Oct 7.

Departments of Pharmaceutics (N.L., B.P., E.J.K., J.D.U., J.W.), Pharmacy (M.F.H., T.R.E.), and Obstetrics and Gynecology (M.F.H., T.R.E.), and the Obstetric-Fetal Pharmacology Research Unit (N.L., M.F.H., T.R.E., J.W.), University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1124/dmd.113.054072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834131PMC
December 2013

Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11.

Biochemistry 2013 Nov 7;52(46):8276-85. Epub 2013 Nov 7.

Department of Medicinal Chemistry and ‡Department of Pharmaceutics, School of Pharmacy at the University of Washington , Box 357610, Seattle, Washington 98105, United States.

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November 2013

Interindividual variability in the hepatic expression of the human breast cancer resistance protein (BCRP/ABCG2): effect of age, sex, and genotype.

J Pharm Sci 2013 Mar 1;102(3):787-93. Epub 2013 Jan 1.

Department of Pharmaceutics, University of Washington, Seattle, Washington 98195, USA.

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March 2013

Bioanalysis young investigator: Bhagwat Prasad.

Bioanalysis 2011 Jun;3(12):1319-21

Department of Pharmaceutics, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.4155/bio.11.123DOI Listing
June 2011

Evidence of the formation of direct covalent adducts of primaquine, 2-tert-butylprimaquine (NP-96) and monohydroxy metabolite of NP-96 with glutathione and N-acetylcysteine.

J Chromatogr B Analyt Technol Biomed Life Sci 2011 Jan 4;879(1):1-7. Epub 2010 Nov 4.

Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar 160062, Punjab, India.

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January 2011

Identification of rat urinary metabolites of rifabutin using LC-MSn and LC-HR-MS.

Eur J Pharm Sci 2010 Sep 15;41(1):173-88. Epub 2010 Jun 15.

Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar 160 062, Punjab, India.

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September 2010

Characterization of degradation products of amorphous and polymorphic forms of clopidogrel bisulphate under solid state stress conditions.

J Pharm Biomed Anal 2010 Jul 12;52(3):332-44. Epub 2009 May 12.

Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, Mohali 160062, Punjab, India.

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http://dx.doi.org/10.1016/j.jpba.2009.05.001DOI Listing
July 2010

Screening of Indian aphrodisiac ayurvedic/herbal healthcare products for adulteration with sildenafil, tadalafil and/or vardenafil using LC/PDA and extracted ion LC-MS/TOF.

J Pharm Biomed Anal 2010 Jul 28;52(3):406-9. Epub 2009 May 28.

Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, Mohali 160062, Punjab, India.

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http://dx.doi.org/10.1016/j.jpba.2009.05.021DOI Listing
July 2010

Development and validation of a sensitive and selective UHPLC-MS/MS method for quantitation of an investigational anti-malarial compound, 2-tert-butylprimaquine (NP-96) in rat plasma, and its application in a preclinical pharmacokinetic study.

J Pharm Biomed Anal 2010 Jul 6;52(3):410-5. Epub 2009 Jun 6.

Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar 160062, Punjab, India.

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http://dx.doi.org/10.1016/j.jpba.2009.05.033DOI Listing
July 2010

LC-MS/TOF and UHPLC-MS/MS study of in vivo fate of rifamycin isonicotinyl hydrazone formed on oral co-administration of rifampicin and isoniazid.

J Pharm Biomed Anal 2010 Jul 22;52(3):377-83. Epub 2009 Jul 22.

Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar 160 062, Punjab, India.

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July 2010

In vitro and in vivo investigation of metabolic fate of rifampicin using an optimized sample preparation approach and modern tools of liquid chromatography-mass spectrometry.

J Pharm Biomed Anal 2009 Oct 22;50(3):475-90. Epub 2009 May 22.

Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar 160 062, Punjab, India.

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http://dx.doi.org/10.1016/j.jpba.2009.05.009DOI Listing
October 2009

Detection and characterization of synthetic steroidal and non-steroidal anti-inflammatory drugs in Indian ayurvedic/herbal products using LC-MS/TOF.

Drug Test Anal 2009 Aug;1(8):372-81

Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, Mohali 160 062, Punjab, India.

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http://dx.doi.org/10.1002/dta.75DOI Listing
August 2009

Screening of bulk drug samples and anti-tuberculosis products for the presence of therapeutically less active diasteriomeric (R,S) form of ethambutol dihydrochloride.

Indian J Tuberc 2008 Oct;55(4):192-8

Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research, SAS Nagar, Punjab.

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October 2008

Refocus on the stability and quality of anti-tuberculosis formulations.

Int J Tuberc Lung Dis 2006 Sep;10(9):1064-5; author reply 1065

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September 2006

Study of the interaction between rifapentine and isoniazid under acid conditions.

J Pharm Biomed Anal 2006 Jun 18;41(4):1438-41. Epub 2006 Apr 18.

Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar 160062, Punjab, India.

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http://dx.doi.org/10.1016/j.jpba.2006.03.004DOI Listing
June 2006