Publications by authors named "Bettina Hentschel"

54Publications

FDA and EMA Approvals of New Breast Cancer Drugs-A Comparative Regulatory Analysis.

Cancers (Basel) 2020 Feb 13;12(2). Epub 2020 Feb 13.

Interdisciplinary Breast Center, Kantonsspital Baden, 5404 Baden, Switzerland.

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http://dx.doi.org/10.3390/cancers12020437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072445PMC
February 2020

Bevacizumab versus alkylating chemotherapy in recurrent glioblastoma.

J Cancer Res Clin Oncol 2020 Mar 21;146(3):659-670. Epub 2019 Nov 21.

Department of Neurology and Brain Tumor Center, University Hospital and University of Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland.

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http://dx.doi.org/10.1007/s00432-019-03086-9DOI Listing
March 2020

FOCAD loss impacts microtubule assembly, G2/M progression and patient survival in astrocytic gliomas.

Acta Neuropathol 2020 01 31;139(1):175-192. Epub 2019 Aug 31.

Department of Human Genetics OE 6300, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

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http://dx.doi.org/10.1007/s00401-019-02067-zDOI Listing
January 2020

Evolutionary Trajectories of IDH Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis.

Cancer Cell 2019 04 21;35(4):692-704.e12. Epub 2019 Mar 21.

Division of Molecular Genetics, German Cancer Research Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Heidelberg Center for Personalized Oncology, DKFZ-HIPO, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108193010
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http://dx.doi.org/10.1016/j.ccell.2019.02.007DOI Listing
April 2019

The Prognostic Impact of Grading in FIGO IB and IIB Squamous Cell Cervical Carcinomas.

Geburtshilfe Frauenheilkd 2019 Feb 18;79(2):198-204. Epub 2019 Feb 18.

Institute of Pathology, Division of Gynecologic Pathology, University Leipzig, Germany.

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0828-7681
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http://dx.doi.org/10.1055/a-0828-7681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379165PMC
February 2019

Prognostic relevance of low-grade versus high-grade FIGO IB1 squamous cell uterine cervical carcinomas.

J Cancer Res Clin Oncol 2019 Feb 2;145(2):457-462. Epub 2019 Jan 2.

Department of Obstetrics and Gynecology, Technical University Munich, Munich, Germany.

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http://dx.doi.org/10.1007/s00432-018-2793-3DOI Listing
February 2019

Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development.

Cancer Cell 2018 07;34(1):163-177.e7

Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Biomedical Image Computing and Analytics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424337PMC
July 2018

Vulvar field resection based on ontogenetic cancer field theory for surgical treatment of vulvar carcinoma: a single-centre, single-group, prospective trial.

Lancet Oncol 2018 04 9;19(4):537-548. Epub 2018 Mar 9.

Department of Gynecology, Women's and Children's Center, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1016/S1470-2045(18)30109-8DOI Listing
April 2018

Multidimensional scaling of diffuse gliomas: application to the 2016 World Health Organization classification system with prognostically relevant molecular subtype discovery.

Acta Neuropathol Commun 2017 05 22;5(1):39. Epub 2017 May 22.

Division of Human Biology, and Seattle Tumor and Translational Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., Mailstop C3-168, Seattle, WA, 98109, USA.

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http://dx.doi.org/10.1186/s40478-017-0443-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439117PMC
May 2017

Extended mesometrial resection (EMMR): Surgical approach to the treatment of locally advanced cervical cancer based on the theory of ontogenetic cancer fields.

Gynecol Oncol 2017 08 16;146(2):292-298. Epub 2017 May 16.

Department of Gynecology, Leipzig University Hospital, Leipzig, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2017.05.007DOI Listing
August 2017

Limited role for extended maintenance temozolomide for newly diagnosed glioblastoma.

Neurology 2017 Apr 15;88(15):1422-1430. Epub 2017 Mar 15.

From the Department of Neurology and Brain Tumor Center (D.G., M.W.), University Hospital Zurich and University of Zurich, Switzerland; Department of Neuroradiology (P.K., M.B.), University Hospital of Heidelberg; Institute for Medical Informatics, Statistics and Epidemiology (B.H., M.L.), University of Leipzig; Departments of Neuropathology (J.F., G.R.) and Neurosurgery (M.S.), Heinrich-Heine University Düsseldorf; Division of Neurooncology (U.H.), Department of Neurology, University Medical Center Bonn; Department of Neurosurgery (G.S.), University of Dresden; Department of Neurosurgery (J.-C.T.), Ludwig Maximilians University Munich; Department of Neurosurgery (M.W.), University Medical Center Hamburg-Eppendorf, Hamburg; Department of Neurology (U.S.), Knappschaftskrankenhaus Bochum-Langendreer, Ruhr-University Bochum; Clinical Cooperation Unit Neurooncology (W.W.), German Cancer Consortium, German Cancer Research Center, and Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg; Department of Neuropathology (T.P.), DGNN Brain Tumor Reference Center, University of Bonn Medical School; and German Cancer Consortium (G.R.), German Cancer Research Center Heidelberg, Partner Site Essen/Düsseldorf, Düsseldorf, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000003809DOI Listing
April 2017

Frequency of papillary tubal hyperplasia (PTH), salpingoliths and transition from adenoma to borderline ovarian tumors (BOT): A systematic analysis of 74 BOT with different histologic types.

Pathol Res Pract 2017 Apr 6;213(4):305-309. Epub 2017 Feb 6.

Institute of Pathology, Division of Breast, Gynecologic & Perinatal Pathology, University of Leipzig, Germany.

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http://dx.doi.org/10.1016/j.prp.2017.02.001DOI Listing
April 2017

Surgical treatment and histopathological assessment of advanced cervicovaginal carcinoma: A prospective study and retrospective analysis.

Eur J Cancer 2017 01 30;70:99-110. Epub 2016 Nov 30.

Division of Breast, Gynaecological and Perinatal Pathology, Institute of Pathology, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1016/j.ejca.2016.10.016DOI Listing
January 2017

Corticosteroids compromise survival in glioblastoma.

Brain 2016 05 28;139(Pt 5):1458-71. Epub 2016 Mar 28.

2 Department of Neurosciences at the Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, 44195, USA 3 Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA

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http://brain.oxfordjournals.org/content/brain/early/2016/03/
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http://pdfs.journals.lww.com/neurosurgery/2016/10000/Do_Cort
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http://dx.doi.org/10.1093/brain/aww046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006251PMC
May 2016

A cut-off value of 2 cm in tumor size is of prognostic value in surgically treated FIGO stage IB cervical cancer.

Gynecol Oncol 2014 Jul 24;134(1):42-6. Epub 2014 Apr 24.

Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Germany.

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http://dx.doi.org/10.1016/j.ygyno.2014.04.011DOI Listing
July 2014

Association between developmental steps in the organogenesis of the uterine cervix and locoregional progression of cervical cancer: a prospective clinicopathological analysis.

Lancet Oncol 2014 Apr 19;15(4):445-56. Epub 2014 Mar 19.

Division of Breast, Gynaecological and Perinatal Pathology, Institute of Pathology, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1016/S1470-2045(14)70060-9DOI Listing
April 2014

CD34(low) and SMA(high) represent stromal signature in uterine cervical cancer and are markers for peritumoral stromal remodeling.

Ann Diagn Pathol 2013 Dec 29;17(6):531-5. Epub 2013 Oct 29.

Institute of Pathology, Division of Breast, Gynecologic & Perinatal Pathology, University of Leipzig, Leipzig, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10929134130010
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http://dx.doi.org/10.1016/j.anndiagpath.2013.05.009DOI Listing
December 2013

Prognostic or predictive value of MGMT promoter methylation in gliomas depends on IDH1 mutation.

Neurology 2013 Oct 25;81(17):1515-22. Epub 2013 Sep 25.

From the Departments of Neuro-oncology (W.W., M.P., A.S., B.W., M. Weiler) and Neuropathology (A.v.D.), University of Heidelberg; German Cancer Consortium (DKTK) (W.W., B.W., M. Weiler), Clinical Cooperation Unit Neuro-oncology and Clinical Cooperation Unit Neuropathology (A.v.D.), German Cancer Research Center, Heidelberg; Department of Medical Biometry (C.M.), University of Tübingen; Institute for Medical Informatics, Statistics and Epidemiology (B.H., M.L.), University Leipzig; Departments of Neurosurgery (M.C.S.) and Neuropathology (G.R.), Heinrich-Heine-University and DKTK (G.R.), Düsseldorf; Department of Neurology (S.K.), University of Essen Medical School; Department of Neurosurgery (R.K.), Saarland University, Homburg, Germany; Department of Neurology (G.T., D.G., M. Weller), University Hospital Zurich, Switzerland; Department of Neurosurgery (M. Westphal), University Clinic Hamburg Eppendorf, Hamburg; Department of Neurosurgery (G.S.) and DKTK (G.S.), Technical University Dresden; and Department of Neurosurgery (M.S.), University of Bonn, Germany.

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http://dx.doi.org/10.1212/WNL.0b013e3182a95680DOI Listing
October 2013

Long-term survival in primary glioblastoma with versus without isocitrate dehydrogenase mutations.

Clin Cancer Res 2013 Sep 5;19(18):5146-57. Epub 2013 Aug 5.

Authors' Affiliations: Department of Neuropathology, Institute of Pathology, Hannover Medical School, Hannover; Department of Neuropathology, and German Cancer Research Center (DKFZ), Clinical Cooperation Unit Neuropathology, University Hospital of Heidelberg, Institute for Pathology, Heidelberg; Institute for Medical Informatics, Statistics and Epidemiology, University Leipzig; Departments of Neurosurgery and Neuropathology, University of Bonn, Bonn; Department of Neurosurgery, University of Hamburg, Hamburg; Department of Neurosurgery, University of Dresden, Dresden; Department of Neurosurgery, University of Munich, Munich; Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany; and Department of Neurology, University Hospital Zurich, and Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland.

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http://clincancerres.aacrjournals.org/content/early/2013/08/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-13-0017DOI Listing
September 2013

Predictive impact of MGMT promoter methylation in glioblastoma of the elderly.

Int J Cancer 2012 Sep 11;131(6):1342-50. Epub 2012 Jan 11.

Department of Neuropathology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

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http://dx.doi.org/10.1002/ijc.27385DOI Listing
September 2012

Molecular markers in low-grade gliomas: predictive or prognostic?

Clin Cancer Res 2011 Jul 10;17(13):4588-99. Epub 2011 May 10.

Clinical Cooperation Unit Neuropathology, German Cancer Center & Department of Neuropathology, Institute of Pathology, Ruprecht-Karls University Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-3194DOI Listing
July 2011

Definition of the CTV prostate in CT and MRI by using CT-MRI image fusion in IMRT planning for prostate cancer.

Strahlenther Onkol 2011 Mar 24;187(3):183-90. Epub 2011 Feb 24.

Department of Radiation Oncology and Radiotherapy, Südharz-Krankenhaus, Nordhausen, Germany.

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http://dx.doi.org/10.1007/s00066-010-2179-1DOI Listing
March 2011

Morphological parameters associated with perineural invasion (PNI) in carcinoma of the cervix uteri.

Int J Surg Pathol 2011 Apr 17;19(2):159-63. Epub 2010 Nov 17.

University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1177/1066896910381898DOI Listing
April 2011

Local spread of cervical cancer revisited: a clinical and pathological pattern analysis.

Gynecol Oncol 2010 Jun 16;117(3):401-8. Epub 2010 Mar 16.

Department of Obstetrics & Gynecology, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1016/j.ygyno.2010.02.014DOI Listing
June 2010

Perineural invasion in carcinoma of the cervix uteri--prognostic impact.

J Cancer Res Clin Oncol 2010 Oct 19;136(10):1557-62. Epub 2010 Feb 19.

Division of Breast Gynecologic and Perinatal Pathology, Institute of Pathology, University of Leipzig, Liebigstrasse 26, 04103 Leipzig, Germany.

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http://dx.doi.org/10.1007/s00432-010-0813-zDOI Listing
October 2010

Cyclooxygenase-2 expression, Ki-67 labeling index, and perifocal neovascularization in endometriotic lesions.

Ann Diagn Pathol 2009 Dec;13(6):373-7

Department of Breast, Gynecologic and Perinatal Pathology, Institute of Pathology, University of Leipzig, D-04103 Leipzig, Germany.

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http://dx.doi.org/10.1016/j.anndiagpath.2009.08.001DOI Listing
December 2009

Detection of micrometastases in pelvic lymph nodes in patients with carcinoma of the cervix uteri using step sectioning: Frequency, topographic distribution and prognostic impact.

Gynecol Oncol 2008 Nov 21;111(2):276-81. Epub 2008 Aug 21.

Institute of Pathology, Division of Breast, Gynecologic and Perinatal Pathology, University of Leipzig, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S009082580800521
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http://dx.doi.org/10.1016/j.ygyno.2008.07.017DOI Listing
November 2008

Extracapsular extension of pelvic lymph node metastases is of prognostic value in carcinoma of the cervix uteri.

Gynecol Oncol 2008 Jan 24;108(1):63-7. Epub 2007 Oct 24.

Institute of Pathology, Division of Gynecologic Pathology, University Leipzig, Liebigstrasse 26, Leipzig, D-04103, Germany.

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http://dx.doi.org/10.1016/j.ygyno.2007.08.086DOI Listing
January 2008

Evaluation of the invasion front pattern of squamous cell cervical carcinoma by measuring classical and discrete compactness.

Comput Med Imaging Graph 2007 Sep 23;31(6):428-35. Epub 2007 May 23.

Department of Obstetrics and Gynecology, Leipzig University, Germany.

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http://dx.doi.org/10.1016/j.compmedimag.2007.03.004DOI Listing
September 2007

Tumor hypoxia and expression of c-met in cervical cancer.

Gynecol Oncol 2007 Jan 22;104(1):181-5. Epub 2006 Sep 22.

Department of Gynecology, Leipzig University, Philipp-Rosenthal-Strasse 55, 04103 Leipzig, Germany.

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http://dx.doi.org/10.1016/j.ygyno.2006.07.040DOI Listing
January 2007

Mixed small cell carcinomas of the uterine cervix: prognostic impact of focal neuroendocrine differentiation but not of Ki-67 labeling index.

Ann Diagn Pathol 2006 Jun;10(3):140-3

Institute of Pathology, Division of Gynecologic Pathology, University of Leipzig, Germany.

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http://dx.doi.org/10.1016/j.anndiagpath.2005.07.019DOI Listing
June 2006

p16, p14, p53, and cyclin D1 expression and HPV analysis in small cell carcinomas of the uterine cervix.

Int J Gynecol Pathol 2006 Apr;25(2):182-6

Institute of Pathology, Division of Gynecopathology, and Department of Obstetrics and Gynecology, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1097/01.pgp.0000185406.85685.dfDOI Listing
April 2006

Predicting mutational change in the speaking voice of boys.

J Voice 2007 Mar 14;21(2):169-78. Epub 2006 Feb 14.

University of Leipzig, Department of Otorhinolaryngology, Leipzig, Germany.

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http://dx.doi.org/10.1016/j.jvoice.2005.10.008DOI Listing
March 2007

Circulating vascular cell adhesion molecules VCAM-1, ICAM-1, and E-selectin in dependence on aging.

Gerontology 2003 Sep-Oct;49(5):293-300

Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig/Working Group Health Promotion and Prevention of Atherosclerosis e.V. (AGA) Leipzig, Germany.

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http://dx.doi.org/10.1159/000071710DOI Listing
December 2003

Prospective randomized comparison of early and late results of 4 different stent designs.

Am Heart J 2003 Jul;146(1):134-41

Heart Center, Department for Internal Medicine/Cardiology, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1016/S0002-8703(03)00113-3DOI Listing
July 2003