Publications by authors named "Betül Aydın"

5 Publications

  • Page 1 of 1

Phosphorus-nitrogen compounds: part 53-synthesis, characterization, cytotoxic and antimicrobial activity, DNA interaction and molecular docking studies of new mono- and dispirocyclotriphosphazenes with pendant arm(s).

Mol Divers 2021 May 14. Epub 2021 May 14.

Department of Physics, Hacettepe University, 06800, Ankara, Turkey.

Mono-/dispirocyclotriphosphazenes with pendant arm(s) are robust, but they are less investigated inorganic ring systems. In this study, a series of mono (3 and 4)- and dispirocyclotriphosphazenes with 4-chloro-benzyl pendant arm(s) (13-16) was obtained from the Cl exchange reactions of hexachlorocyclotriphosphazene with sodium (N-benzyl)aminopropanoxides (1 and 2). When compound (3) reacted with excess pyrrolidine, morpholine, tetra-1,4-dioxa-8-azaspiro[4,5]decane (DASD) and piperidine, the fully substituted monospirocyclotriphosphazenes (7, 9, 10 and 12) occurred. But, the reactions of 4 with excess piperidine and morpholine produced the gem-piperidino (5)- and morpholino (6)-substituted monospirocyclotriphosphazenes, whereas the reactions of 4 with excess pyrrolidine and DASD gave the fully substituted monospirocyclotriphosphazenes (8) and (11). However, it should be indicated that these derivatives were obtained to be used for the investigation of their spectral, stereogenic and biological properties. The structures of 5, 7 and 14 were determined crystallographically. X-ray data of 5 and 14 displayed that both of compounds were chiral in solid state, and their absolute configurations were assigned as R and RR. Additionally, the antimicrobial activities of phosphazenes were investigated. Minimum inhibitory concentrations, minimal bacterial concentrations and minimum fungicidal concentrations of phosphazenes were determined. The interactions of phosphazenes with plasmid DNA were evaluated by agarose gel electrophoresis. The cytotoxic activities of compounds were studied against L929 fibroblast and DLD-1 colon cancer cells. In addition, density functional theory calculations of 5, 7 and 14 were reported, and their molecular docking studies with DNA, E. coli DNA gyrase and topoisomerase IV were presented.
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http://dx.doi.org/10.1007/s11030-021-10231-5DOI Listing
May 2021

Synthesis, characterization and DNA binding studies of platinum(II) complexes with benzimidazole derivative ligands.

Bioorg Chem 2017 10 1;74:272-283. Epub 2017 Sep 1.

Department of Biology, Faculty of Sciences, Gazi University, 06500 Ankara, Turkey.

The aim of this study was to synthesize and evaluate plasmid DNA interaction of new platinum(II) complexes with some 2-substituted benzimidazole derivatives as carrier ligands which may have potent anticancer activity and low toxicity. Twelve benzimidazole derivatives carrying indole, 2-/or 3-/or 4-methoxyphenyl, 4-methylphenyl, 3,4-dimethoxyphenyl, 3,4,5-trimethoxyphenyl, 4-methoxybenzyl, 3,4,5-trimethoxybenzyl, 3,4,5-trimethoxystyryl, 3,4,5-trimethoxybenzylthio or dimethylamino ethyl groups in their position 2 and twelve platinum(II) complexes with these carrier ligands were synthesized. The chemical structure of the platinum complexes have been characterized by their elemental analysis and FIR, H NMR and mass spectra and their H NMR and FIR spectra were interpreted by comparison with those of the ligands. The interaction of all the ligands and their complexes with plasmid DNA and their restriction endonuclease reactions by BamHI and HindIII enzymes were studied by agarose gel electrophoresis. It was determined that complex 1 [dichloro-di(2-(1H-indole-3-yl)benzimidazole)platinum(II)·2HO] has stronger interaction than carboplatin and complex 10 [dichloro-di(2-(3,4,5-trimethoxystyryl)benzimidazole)platinum(II)·2HO] has stronger interaction than both carboplatin and cisplatin with plasmid DNA.
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http://dx.doi.org/10.1016/j.bioorg.2017.08.015DOI Listing
October 2017

Electroconvulsive therapy in drug-induced psychiatric states and neuroleptic malignant syndrome.

J ECT 2005 Jun;21(2):125-7

Department of Neurology, Bakirkoy Neurology Center, Istanbul, Turkey.

In the late-stage idiopathic Parkinson's disease (IDP), comorbid conditions such as depression and drug-induced psychosis may be observed. A patient with Parkinson disease, major depression, and paranoid psychosis who developed neuroleptic malignant syndrome (NMS) as the result of the sudden termination of high-dose (1200 mg/d) levodopa treatment is presented in this report. Because the patient did not respond to other treatment modalities, electroconvulsive therapy (ECT) was applied, and a rapid improvement was observed both in the patient's NMS and also in Parkinson's and psychiatric symptoms, with no additional side effects other than transient post-ictal confusions. The application of ECT allowed the patient to remain stable for a 5-year period with a quite low dose of levodopa (300 mg/d). Later, the patient had two episodes of depressive and psychotic symptoms, which were again successfully treated with the ECT. We suggest that ECT might be an effective and life-saving therapy in patients with severe, drug-resistant NMS.
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http://dx.doi.org/10.1097/01.yct.0000159325.08303.45DOI Listing
June 2005

Non-ketotic hyperglycaemia presenting as epilepsia partialis continua.

Seizure 2004 Jun;13(4):264-9

Department of Neurology, Haseki Research and Educational Hospital, Istanbul, Turkey.

Epilepsia partialis continua (EPC) is a rare epileptic syndrome, observed in various cortical lesions and also in metabolic disorders. We report the case of a 57-year-old patient with EPC as the first manifestation of hyperosmolar non-ketotic hyperglycaemia (NKH) of diabetes mellitus. Computed tomography (CT) and magnetic resonance imaging (MRI) were normal. Initial laboratory data revealing serum glucose 1540 mg/dl, and serum osmolality 391 mOsm/l confirmed the diagnosis. Electroencephalography (EEG) showed ictal discharges in the ipsilateral hemisphere during focal seizures. Seizures are resistant to anticonvulsant treatment and respond best to insulin and rehydration. Focal motor seizures or EPC are commonly a symptom of NKH in the elderly patients. We recommend that in such cases a metabolic disorder such as diabetes mellitus be ruled out.
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http://dx.doi.org/10.1016/S1059-1311(03)00155-9DOI Listing
June 2004

Evaluation of frozen subepithelial connective tissue grafts to increase the zone of attached gingiva. Report of 5 cases.

J Periodontol 2002 Feb;73(2):220-30

Ministry of Health, Center of Oral and Dental Health, Ankara, Turkey.

Background: In the past decade, gingival tissue has been regenerated using subepithelial connective tissue grafts (SECT). This report presents the use of frozen subepithelial connective tissue (FSECT) for increasing the zone of attached keratinized gingiva (KG).

Methods: Five cases, 4 females and 1 male, aged 55 to 73 years, presented with inadequate attached KG. The SECT grafts were harvested from the palatal flap during conventional flap surgery. All grafts were frozen immediately. Five weeks to 10 months later, the grafts were placed in areas in which patients had inadequate KG.

Results: In all cases, healing was uneventful. All cases were followed up 3 months to 1.5 years. An increase of 1 to 3 mm of KG was achieved.

Conclusions: These cases show that the FSECT graft is useful in treating mucogingival problems. Further randomized controlled trials over long periods of time are necessary to establish whether this procedure offers long-term benefits to patients.
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http://dx.doi.org/10.1902/jop.2002.73.2.220DOI Listing
February 2002