Bertus Eksteen

Bertus Eksteen

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Bertus Eksteen

Publications by authors named "Bertus Eksteen"

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The Unsolved Link of Genetic Markers and Crohn's Disease Progression: A North American Cohort Experience.

Inflamm Bowel Dis 2019 Aug;25(9):1541-1549

Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital IBD Group, Division of Gastroenterology, Department of Medicine, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1093/ibd/izz016DOI Listing
August 2019

Innate and Adaptive Cell Populations Driving Inflammation in Dry Eye Disease.

Mediators Inflamm 2018 12;2018:2532314. Epub 2018 Aug 12.

Universidad Nacional Autónoma de México (UNAM), Laboratorio de Enfermedades Inflamatorias Oculares, Carrera de Optometría, Facultad de Estudios Superiores (FES) Iztacala, Tlalnepantla, MEX, Mexico.

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https://www.hindawi.com/journals/mi/2018/2532314/
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http://dx.doi.org/10.1155/2018/2532314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109495PMC
December 2018

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.

Gut 2018 08 4;67(8):1517-1524. Epub 2017 Aug 4.

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1136/gutjnl-2016-313598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797498PMC
August 2018

Primary Sclerosing Cholangitis Is Not Rare Among Blacks in a Multicenter North American Consortium.

Clin Gastroenterol Hepatol 2018 04 2;16(4):591-593. Epub 2017 Nov 2.

Division of Gastroenterology and Hepatology, University of California-Davis School of Medicine, Sacramento, California.

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http://dx.doi.org/10.1016/j.cgh.2017.10.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860952PMC
April 2018

Asthma Is Associated With Subsequent Development of Inflammatory Bowel Disease: A Population-based Case-Control Study.

Clin Gastroenterol Hepatol 2017 Sep 23;15(9):1405-1412.e3. Epub 2017 Mar 23.

Department of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada; Synder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada; O'Brien Institute for Public Health, University of Calgary, Calgary, Alberta, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2017.02.042DOI Listing
September 2017

The NOD2-Smoking Interaction in Crohn's Disease is likely Specific to the 1007fs Mutation and may be Explained by Age at Diagnosis: A Meta-Analysis and Case-Only Study.

EBioMedicine 2017 Jul 16;21:188-196. Epub 2017 Jun 16.

Department of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada; O'Brien Institute for Public Health, University of Calgary, Calgary, Alberta, Canada; Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada; (i)Alberta Inflammatory Bowel Disease Consortium, University of Calgary, Calgary, Alberta, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514403PMC
July 2017

Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis.

Gastroenterology 2017 06 6;152(8):1975-1984.e8. Epub 2017 Mar 6.

Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.02.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546611PMC
June 2017

Hepatitis B virus testing and linkage to care in a Canadian urban tertiary referral centre: a retrospective cohort study.

CMAJ Open 2017 Jun;5(2):E431-E436

Affiliations: Calgary Liver Unit (Lau, Shaheen, Aspinall, Congly, Borman, Jayakumar, Eksteen, Lee, Stinton, Swain, Burak, Coffin), Division of Gastroenterology and Hepatology, Department of Medicine; Department of Microbiology, Immunology and Infectious Diseases (Lau, Coffin), Cumming School of Medicine, University of Calgary; Alberta Health Services (Ricento, Qureshi), Calgary, Alta.

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http://cmajopen.ca/lookup/doi/10.9778/cmajo.20170002
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http://dx.doi.org/10.9778/cmajo.20170002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498308PMC
June 2017

Impact of Obesity on Remission and Disease Activity in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.

Arthritis Care Res (Hoboken) 2017 02 31;69(2):157-165. Epub 2016 Dec 31.

University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1002/acr.22932DOI Listing
February 2017

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.

Nat Genet 2017 Feb 19;49(2):269-273. Epub 2016 Dec 19.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.

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http://dx.doi.org/10.1038/ng.3745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540332PMC
February 2017

Association between Air Pollution and the Development of Rheumatic Disease: A Systematic Review.

Int J Rheumatol 2016 25;2016:5356307. Epub 2016 Oct 25.

Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.1155/2016/5356307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099457PMC
October 2016

Predicting risk in primary biliary cholangitis.

Authors:
Bertus Eksteen

Hepatology 2016 Mar 14;63(3):697-9. Epub 2016 Jan 14.

Snyder Institute for Chronic Diseases, Division of Gastroenterology, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1002/hep.28377DOI Listing
March 2016

Selective biologics for ulcerative colitis and Crohn's disease - clinical utility of vedolizumab.

Biologics 2016 9;10:33-52. Epub 2016 Mar 9.

Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.2147/BTT.S71679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790488PMC
March 2016

The Gut-Liver Axis in Primary Sclerosing Cholangitis.

Authors:
Bertus Eksteen

Clin Liver Dis 2016 Feb 26;20(1):1-14. Epub 2015 Sep 26.

Division of Gastroenterology and Hepatology, Health Research and Innovation Centre (HRIC), Snyder Institute for Chronic Diseases, University of Calgary, 4AC66 - 3280 Hospital Drive Northwest, Calgary, Alberta T2N 4N1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cld.2015.08.012DOI Listing
February 2016

Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis.

Biochim Biophys Acta 2016 01 31;1862(1):135-44. Epub 2015 Oct 31.

Regeneration and Repair Group, The Institute of Hepatology, Foundation for Liver Research, London, UK; Division of Transplantation Immunology and Mucosal Biology, King's College London, UK; Department of Surgery, Loyola University, Chicago, USA; Liver Unit, Barts Health NHS Trust, London, UK; Department of Physiology, University of the Basque Country, Bilbao, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2015.10.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756594PMC
January 2016

Postoperative Mortality Among Patients With Inflammatory Bowel Diseases: A Systematic Review and Meta-analysis of Population-Based Studies.

Gastroenterology 2015 Oct 6;149(4):928-37. Epub 2015 Jun 6.

Division of Gastroenterology, University of Calgary, Calgary, Alberta, Canada; Department of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada; Inflammatory Bowel Disease Clinic, University of Calgary, Calgary, Alberta, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2015.06.001DOI Listing
October 2015

TP53 codon 72 Arg/Arg polymorphism is associated with a higher risk for inflammatory bowel disease development.

World J Gastroenterol 2015 Sep;21(36):10358-66

Natalia Volodko, Hien Q Huynh, Shairaz Baksh, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2E1, Canada.

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http://dx.doi.org/10.3748/wjg.v21.i36.10358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579882PMC
September 2015

Clinical predictors of thiopurine-related adverse events in Crohn's disease.

World J Gastroenterol 2015 Jul;21(25):7795-804

Gordon W Moran, Marie-France Dubeau, Gilaad G Kaplan, Hong Yang, Bertus Eksteen, Subrata Ghosh, Remo Panaccione, Inflammatory Bowel Disease Clinic, Division of Gastroenterology, Department of Medicine, Cumming School of Medicine, University of Calgary, Alberta T2N 1N4, Canada.

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http://dx.doi.org/10.3748/wjg.v21.i25.7795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491966PMC
July 2015

Targeting of gut specific leucocyte recruitment in IBD by vedolizumab.

Authors:
Bertus Eksteen

Gut 2015 Jan 19;64(1):8-10. Epub 2014 Jun 19.

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http://dx.doi.org/10.1136/gutjnl-2014-307397DOI Listing
January 2015

Colorectal cancer surveillance in patients with inflammatory bowel disease and primary sclerosing cholangitis: an economic evaluation.

Inflamm Bowel Dis 2014 Nov;20(11):2046-55

*Alberta Inflammatory Bowel Disease Consortium, Calgary, AB, Canada; Departments of †Production Animal Health, ‡Community Health Sciences, §Medicine; and ‖Institute of Public Health, University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.1097/MIB.0000000000000181DOI Listing
November 2014

Characterization of animal models for primary sclerosing cholangitis (PSC).

J Hepatol 2014 Jun 19;60(6):1290-303. Epub 2014 Feb 19.

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2014.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517670PMC
June 2014

Advances and controversies in the pathogenesis and management of primary sclerosing cholangitis.

Authors:
Bertus Eksteen

Br Med Bull 2014 Jun 2;110(1):89-98. Epub 2014 May 2.

Division of Gastroenterology and Hepatology, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada

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http://dx.doi.org/10.1093/bmb/ldu008DOI Listing
June 2014

Vascular cell adhesion molecule 1 expression by biliary epithelium promotes persistence of inflammation by inhibiting effector T-cell apoptosis.

Hepatology 2014 May 27;59(5):1932-43. Epub 2014 Mar 27.

National Institute for Health Research Biomedical Research Unit and Center for Liver Research, Medical Research Council Center for Immune Regulation, University of Birmingham, Birmingham, UK.

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http://doi.wiley.com/10.1002/hep.26965
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http://dx.doi.org/10.1002/hep.26965DOI Listing
May 2014

Role of IL-17A and neutrophils in fibrosis in experimental hypersensitivity pneumonitis.

J Allergy Clin Immunol 2013 Jun 27;131(6):1663-73. Epub 2013 Feb 27.

Airway Inflammation Research Group, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S00916749130015
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http://dx.doi.org/10.1016/j.jaci.2013.01.015DOI Listing
June 2013

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

Nat Genet 2013 Jun 21;45(6):670-5. Epub 2013 Apr 21.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://petercroucher.com/wp-content/uploads/2013/10/51_Natur
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http://www.nature.com/doifinder/10.1038/ng.2616
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http://dx.doi.org/10.1038/ng.2616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667736PMC
June 2013

CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver.

J Hepatol 2012 Nov 14;57(5):1044-51. Epub 2012 Jul 14.

Centre for Liver Research & NIHR Biomedical Research Unit in Liver Disease, University of Birmingham, Birmingham, United Kingdom.

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http://dx.doi.org/10.1016/j.jhep.2012.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994510PMC
November 2012

Infections and the liver.

Authors:
Bertus Eksteen

Dig Dis 2011 5;29(2):184-90. Epub 2011 Jul 5.

Centre for Liver Research, MRC Centre for Immune Regulation, Institute for Biomedical Research, Medical School, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1159/000323884DOI Listing
November 2011

Clonal analysis reveals uniformity in the molecular profile and lineage potential of CCR9(+) and CCR9(-) thymus-settling progenitors.

J Immunol 2011 May 18;186(9):5227-35. Epub 2011 Mar 18.

Medical School, Institute for Biomedical Research, Medical Research Council Center for Immune Regulation, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1002686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826122PMC
May 2011

Acute liver failure after administration of paracetamol at the maximum recommended daily dose in adults.

BMJ 2010 Dec 2;341:c6764. Epub 2010 Dec 2.

Liver Unit, Queen Elizabeth Hospital, Birmingham B15 2TH, UK.

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http://dx.doi.org/10.1136/bmj.c6764DOI Listing
December 2010

GSK-1605786, a selective small-molecule antagonist of the CCR9 chemokine receptor for the treatment of Crohn's disease.

IDrugs 2010 Jul;13(7):472-81

University of Birmingham and the NIHR Biomedical Research Unit for Liver Disease, Centre for Liver Research, MRC Centre for Immune Regulation, The College of Medical and Dental Sciences, Queen Elizabeth Hospital Birmingham NHS Foundation Trust, Edgbaston, Birmingham, B15 2TT, UK.

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July 2010

Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.

J Immunol 2010 Mar 17;184(6):2886-98. Epub 2010 Feb 17.

Centre for Liver Research, Institute of Biomedical Research, The University of Birmingham Medical School, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.0901216DOI Listing
March 2010

Understanding of chemoprophylaxis and concordance in inflammatory bowel disease.

World J Gastroenterol 2010 Feb;16(5):578-82

Department of Gastroenterology, Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust, Edgbaston, Birmingham, B15 6HT, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816269PMC
http://dx.doi.org/10.3748/wjg.v16.i5.578DOI Listing
February 2010

The survival of memory CD4+ T cells within the gut lamina propria requires OX40 and CD30 signals.

J Immunol 2009 Oct 28;183(8):5079-84. Epub 2009 Sep 28.

Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, Medical School, University of Birmingham, Birmingham, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.0901514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826117PMC
October 2009

Gut homing receptors on CD8 T cells are retinoic acid dependent and not maintained by liver dendritic or stellate cells.

Gastroenterology 2009 Jul 21;137(1):320-9. Epub 2009 Feb 21.

MRC Centre for Immune Regulation, Institute for Biomedical Research, Medical School, University of Birmingham, Birmingham, United Kingdom.

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http://dx.doi.org/10.1053/j.gastro.2009.02.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201985PMC
July 2009

Differential ferritin expression is associated with iron deficiency in coeliac disease.

Eur J Gastroenterol Hepatol 2009 Jul;21(7):794-804

Institute for Cancer Studies, University of Birmingham Cancer Research, UK.

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http://dx.doi.org/10.1097/MEG.0b013e328308676bDOI Listing
July 2009

Lymphocyte homing and its role in the pathogenesis of IBD.

Inflamm Bowel Dis 2008 Sep;14(9):1298-312

Liver Research Laboratories, MRC Centre for Immune Regulation, Institute for Biomedical Research, Medical School, University of Birmingham, Birmingham, United Kingdom.

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https://academic.oup.com/ibdjournal/article/14/9/1298-1312/4
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http://dx.doi.org/10.1002/ibd.20453DOI Listing
September 2008

CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow.

Am J Physiol Gastrointest Liver Physiol 2008 May 28;294(5):G1257-67. Epub 2008 Feb 28.

Liver Research Group, Medical Research Council Centre for Immune Regulation, Institute of Biomedical Research, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1152/ajpgi.00266.2007DOI Listing
May 2008

Mechanisms of disease: the evolving understanding of liver allograft rejection.

Nat Clin Pract Gastroenterol Hepatol 2008 Apr 4;5(4):209-19. Epub 2008 Mar 4.

Liver Unit, Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK.

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http://www.nature.com/articles/ncpgasthep1070
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http://dx.doi.org/10.1038/ncpgasthep1070DOI Listing
April 2008

Immune-mediated liver injury.

Semin Liver Dis 2007 Nov;27(4):351-66

Liver Research Group, MRC Centre for Immune Regulation, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham, United Kingdom.

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http://dx.doi.org/10.1055/s-2007-991512DOI Listing
November 2007

Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells.

Science 2006 Nov;314(5802):1157-60

CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.1132742DOI Listing
November 2006

Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10.

J Immunol 2006 Jul;177(1):593-603

Liver Research Laboratories, Medical Research Council for Immune Regulation, Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TH, UK.

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http://dx.doi.org/10.4049/jimmunol.177.1.593DOI Listing
July 2006

Aberrant homing of mucosal T cells and extra-intestinal manifestations of inflammatory bowel disease.

Nat Rev Immunol 2006 Mar;6(3):244-51

Liver Research Laboratories, MRC Centre for Immune Regulation, 5th Floor, Institute for Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1038/nri1784DOI Listing
March 2006

CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow.

Am J Pathol 2005 Sep;167(3):887-99

Liver Research Group, Institute of Biomedical Research, MRC Centre for Immune Regulation, The University of Birmingham Medical School, Edgbaston, Birmingham, UK B15 2TT.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698725PMC
http://dx.doi.org/10.1016/S0002-9440(10)62060-3DOI Listing
September 2005

Hepatic endothelial CCL25 mediates the recruitment of CCR9+ gut-homing lymphocytes to the liver in primary sclerosing cholangitis.

J Exp Med 2004 Dec 22;200(11):1511-7. Epub 2004 Nov 22.

Liver Research Laboratories, Institute for Biomedical Research, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TT, England, UK.

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http://dx.doi.org/10.1084/jem.20041035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211943PMC
December 2004

Lymphocyte homing in the pathogenesis of extra-intestinal manifestations of inflammatory bowel disease.

Clin Med (Lond) 2004 Mar-Apr;4(2):173-80

Liver Research Laboratories, MRC Centre for Immune Regulation, University of Birmingham, Queen Elizabeth Hospital, Birmingham.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954008PMC
http://dx.doi.org/10.7861/clinmedicine.4-2-173DOI Listing
July 2004

Gastroenterology.

BMJ 2002 Oct;325(7368):S113

Digestive Disease Centre (GI Unit), Leicester Royal Infirmary, Leicester/Warwick Medical School LE15WW.

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http://dx.doi.org/10.1136/bmj.325.7368.s113aDOI Listing
October 2002