Bertil B Fredholm

Bertil B Fredholm

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Bertil B Fredholm

Publications by authors named "Bertil B Fredholm"

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Adenosine and Sleep.

Handb Exp Pharmacol 2019 ;253:359-381

Department of Physiology and Pharmacology, Karolinska Institutet, 17177, Stockholm, Sweden.

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http://dx.doi.org/10.1007/164_2017_36DOI Listing
September 2019

Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia.

PLoS One 2017 27;12(1):e0170545. Epub 2017 Jan 27.

Department of Women´s and Children´s Health, Karolinska Institutet, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0170545PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271335PMC
August 2017

Low, but not high, dose caffeine is a readily available probe for adenosine actions.

Mol Aspects Med 2017 06 30;55:20-25. Epub 2016 Nov 30.

Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77, Stockholm, Sweden; Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

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http://dx.doi.org/10.1016/j.mam.2016.11.011DOI Listing
June 2017

Pharmacological targeting of adenosine receptor signaling.

Mol Aspects Med 2017 06 12;55:4-8. Epub 2017 Jan 12.

Department of Physiology and Pharmacology, Karolinska Institutet, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2016.12.002DOI Listing
June 2017

Adenosine - from molecular mechanisms to pathophysiology.

Mol Aspects Med 2017 06 17;55:1-3. Epub 2017 Jun 17.

Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.mam.2017.06.003DOI Listing
June 2017

Adenosine A1 receptors contribute to immune regulation after neonatal hypoxic ischemic brain injury.

Purinergic Signal 2016 Mar 25;12(1):89-101. Epub 2015 Nov 25.

Department of Women's and Children's Health, Karolinska Institutet, 17176, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s11302-015-9482-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749537PMC
March 2016

Adenosine--a physiological or pathophysiological agent?

J Mol Med (Berl) 2014 Mar 22;92(3):201-6. Epub 2013 Dec 22.

Department of Physiology and Pharmacology, Karolinska Institutet, S-17177, Stockholm, Sweden,

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http://dx.doi.org/10.1007/s00109-013-1101-6DOI Listing
March 2014

Adenosine receptors as drug targets--what are the challenges?

Nat Rev Drug Discov 2013 Apr;12(4):265-86

Department of Neurology and Pharmacology, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

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http://dx.doi.org/10.1038/nrd3955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930074PMC
April 2013

[The Nobel Prize to detailed studies of G protein-coupled receptors. This years Nobel Prize in chemistry provides important knowledge--but it might take a while before it can be practically applied].

Lakartidningen 2012 Dec;109(49-50):2274-5

institutionen för fysiologi och farmakologi, Karolinska institutet, Stockholm.

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December 2012

Improved blood glucose disposal and altered insulin secretion patterns in adenosine A(1) receptor knockout mice.

Am J Physiol Endocrinol Metab 2012 Jul 1;303(2):E180-90. Epub 2012 May 1.

Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1152/ajpendo.00050.2012DOI Listing
July 2012

Rethinking the purinergic neuron-glia connection.

Proc Natl Acad Sci U S A 2012 Apr 16;109(16):5913-4. Epub 2012 Apr 16.

Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1073/pnas.1203764109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340997PMC
April 2012

Adenosine and ATP receptors in the brain.

Curr Top Med Chem 2011 ;11(8):973-1011

Autonomic Neuroscience Centre, University College Medical School, London, Rowland Hill Street, London NW3 2PF, UK.

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http://dx.doi.org/10.2174/156802611795347627DOI Listing
August 2011

Adenosine and the regulation of metabolism and body temperature.

Adv Pharmacol 2011 ;61:77-94

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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https://linkinghub.elsevier.com/retrieve/pii/B97801238552680
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http://dx.doi.org/10.1016/B978-0-12-385526-8.00003-5DOI Listing
August 2011

A ketogenic diet suppresses seizures in mice through adenosine A₁ receptors.

J Clin Invest 2011 Jul 23;121(7):2679-83. Epub 2011 Jun 23.

Department of Psychology and Neuroscience Program, Trinity College, Hartford, Connecticut, USA.

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http://dx.doi.org/10.1172/JCI57813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223846PMC
July 2011

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors--an update.

Pharmacol Rev 2011 Mar 8;63(1):1-34. Epub 2011 Feb 8.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1124/pr.110.003285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061413PMC
March 2011

Deletion of adenosine A₁ or A(₂A) receptors reduces L-3,4-dihydroxyphenylalanine-induced dyskinesia in a model of Parkinson's disease.

Brain Res 2011 Jan 7;1367:310-8. Epub 2010 Sep 7.

MassGeneral Institute for Neurolodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.

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http://dx.doi.org/10.1016/j.brainres.2010.08.099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005012PMC
January 2011

Notes on the history of caffeine use.

Handb Exp Pharmacol 2011 (200):1-9

Department of Physiology and Pharmacology, Karolinska Institute, Nanna Svartz väg 2, 171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1007/978-3-642-13443-2_1DOI Listing
January 2011

Involvement of adenosine signaling in controlling the release of ghrelin from the mouse stomach.

J Pharmacol Exp Ther 2011 Jan 27;336(1):77-86. Epub 2010 Sep 27.

Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z3.

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http://dx.doi.org/10.1124/jpet.110.171280DOI Listing
January 2011

WITHDRAWN: Involvement of Adenosine Signaling in Controlling the Release of Ghrelin from the Mouse Stomach.

Regul Pept 2011 Jan 21. Epub 2011 Jan 21.

Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.regpep.2011.01.002DOI Listing
January 2011

High-protein-induced glomerular hyperfiltration is independent of the tubuloglomerular feedback mechanism and nitric oxide synthases.

Am J Physiol Regul Integr Comp Physiol 2010 Nov 25;299(5):R1263-8. Epub 2010 Aug 25.

Dept. of Medical Cell Biology, Uppsala Univ., Biomedical Center, Box 571, SE-751 23 Uppsala, Sweden.

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http://dx.doi.org/10.1152/ajpregu.00649.2009DOI Listing
November 2010

Fuels for transportation.

Ambio 2010 ;39 Suppl 1:31-5

Karolinska Institutet, Stockholm, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357648PMC
http://dx.doi.org/10.1007/s13280-010-0062-zDOI Listing
October 2010

Adenosine A1 receptors (A1Rs) play a critical role in osteoclast formation and function.

FASEB J 2010 Jul 24;24(7):2325-33. Epub 2010 Feb 24.

Department of Medicine, Division of Clinical Pharmacology, NYU School of Medicine, 550 First Ave., New York, NY 10016, USA.

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http://dx.doi.org/10.1096/fj.09-147447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887264PMC
July 2010

Adenosine A(1) receptors contribute to mitochondria vulnerability to pro-oxidant stressors.

Mitochondrion 2010 Jun 15;10(4):369-79. Epub 2010 Mar 15.

Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Sezione di Biochimica Cellulare, Università di Perugia, Via del Giochetto, 06123 Perugia, Italia.

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http://dx.doi.org/10.1016/j.mito.2010.03.004DOI Listing
June 2010

Adenosine receptors as drug targets.

Exp Cell Res 2010 May 11;316(8):1284-8. Epub 2010 Feb 11.

Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.yexcr.2010.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866745PMC
May 2010

Caffeine reverses antinociception by oxcarbazepine by inhibition of adenosine A1 receptors: insights using knockout mice.

Neurosci Lett 2010 Apr 20;473(3):178-81. Epub 2010 Feb 20.

Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7.

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http://dx.doi.org/10.1016/j.neulet.2010.02.028DOI Listing
April 2010

LTP impairment by fractalkine/CX3CL1 in mouse hippocampus is mediated through the activity of adenosine receptor type 3 (A3R).

J Neuroimmunol 2009 Oct 26;215(1-2):36-42. Epub 2009 Aug 26.

Dipartimento di Fisiologia e Farmacologia, Università di Roma Sapienza, Piazzale A. Moro 5, I00185 Roma, Italy.

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http://dx.doi.org/10.1016/j.jneuroim.2009.07.016DOI Listing
October 2009

Absence of adenosine A1 receptors unmasks pulses of insulin release and prolongs those of glucagon and somatostatin.

Life Sci 2009 Sep 12;85(11-12):470-6. Epub 2009 Aug 12.

Department of Clinical Science, CRC, University of Lund, Malmö, Sweden.

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http://linkinghub.elsevier.com/retrieve/pii/S002432050900327
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http://dx.doi.org/10.1016/j.lfs.2009.08.001DOI Listing
September 2009

Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine.

Am J Physiol Heart Circ Physiol 2009 Apr 13;296(4):H1141-9. Epub 2009 Feb 13.

Karolinska Institutet, Nanna Svartz väg 2, Stockholm S-171 77 Sweden.

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http://dx.doi.org/10.1152/ajpheart.00754.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670688PMC
April 2009

A(1) and A(3) adenosine receptors alter glutathione status in an organ-specific manner and influence the changes after inhibition of gamma-glutamylcysteine ligase.

Free Radic Res 2009 Mar;43(3):304-11

Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Italy.

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http://dx.doi.org/10.1080/10715760802712616DOI Listing
March 2009

Adenosine Receptors: The Contributions by John W. Daly.

Heterocycles 2009;79(1):73-83

Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA 20892.

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http://dx.doi.org/10.3987/COM-08-S(D)Memoire-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477965PMC
January 2009

Decreased behavioral activation following caffeine, amphetamine and darkness in A3 adenosine receptor knock-out mice.

Physiol Behav 2008 Dec 27;95(5):668-76. Epub 2008 Sep 27.

Department of Physiology and Pharmacology, Karolinska Institutet, S - 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.physbeh.2008.09.018DOI Listing
December 2008

Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1 receptors and promotes non-rapid eye movement sleep.

Proc Natl Acad Sci U S A 2008 Dec 9;105(50):19992-7. Epub 2008 Dec 9.

Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565-0874, Japan.

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http://dx.doi.org/10.1073/pnas.0810926105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604968PMC
December 2008

Adenosine A1 receptors regulate lipolysis and lipogenesis in mouse adipose tissue-interactions with insulin.

Eur J Pharmacol 2008 Nov 31;597(1-3):92-101. Epub 2008 Aug 31.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.ejphar.2008.08.022DOI Listing
November 2008

Adenosine A1 and A3 receptors protect astrocytes from hypoxic damage.

Eur J Pharmacol 2008 Oct 13;596(1-3):6-13. Epub 2008 Aug 13.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.ejphar.2008.08.002DOI Listing
October 2008

Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors.

Proc Natl Acad Sci U S A 2008 Sep 22;105(39):15118-23. Epub 2008 Sep 22.

Istituto Pasteur-Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza di Biologia e Medicina Molecolare, Università di Roma La Sapienza, Piazzale A. Moro 5, I-00185 Rome, Italy.

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http://dx.doi.org/10.1073/pnas.0807277105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567502PMC
September 2008

Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors.

Neurosci Lett 2008 Aug 24;440(2):181-4. Epub 2008 May 24.

Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7.

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http://dx.doi.org/10.1016/j.neulet.2008.05.074DOI Listing
August 2008

Adenosine A(2A) receptor dynamics studied with the novel fluorescent agonist Alexa488-APEC.

Eur J Pharmacol 2008 Aug 4;590(1-3):36-42. Epub 2008 Jul 4.

Karolinska Institutet, Department of Physiology & Pharmacology, Sect. Receptor Biology & Signaling, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.ejphar.2008.05.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765816PMC
August 2008

Adenosine induces airway hyperresponsiveness through activation of A3 receptors on mast cells.

J Allergy Clin Immunol 2008 Jul 9;122(1):107-13, 113.e1-7. Epub 2008 May 9.

Department of Medicine, Division of Pulmonary and Critical Care Medicine, and Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.jaci.2008.03.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439463PMC
July 2008

Adenosine, through the A1 receptor, inhibits vesicular MHC class I cross-presentation by resting DC.

Mol Immunol 2008 Apr 21;45(8):2247-54. Epub 2008 Feb 21.

Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institute, 171 77 Stockholm, Sweden.

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https://linkinghub.elsevier.com/retrieve/pii/S01615890070086
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http://dx.doi.org/10.1016/j.molimm.2007.11.016DOI Listing
April 2008

Promiscuous coupling and involvement of protein kinase C and extracellular signal-regulated kinase 1/2 in the adenosine A1 receptor signalling in mammalian spermatozoa.

Biochem Pharmacol 2008 Feb 30;75(4):931-41. Epub 2007 Oct 30.

Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli studi di Perugia, Via del Giochetto, 06123 Perugia, Italy.

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http://dx.doi.org/10.1016/j.bcp.2007.10.024DOI Listing
February 2008

Aspects of the general biology of adenosine A2A signaling.

Prog Neurobiol 2007 Dec 1;83(5):263-76. Epub 2007 Aug 1.

Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.pneurobio.2007.07.005DOI Listing
December 2007

A1 receptor deficiency causes increased insulin and glucagon secretion in mice.

Biochem Pharmacol 2007 Dec 9;74(11):1628-35. Epub 2007 Aug 9.

Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bcp.2007.08.006DOI Listing
December 2007

1,3,7-trimethylxanthine (caffeine) may exacerbate acute inflammatory liver injury by weakening the physiological immunosuppressive mechanism.

J Immunol 2007 Dec;179(11):7431-8

New England Inflammation and Tissue Protection Institute at Northeastern University, Boston, MA 02115, USA.

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http://dx.doi.org/10.4049/jimmunol.179.11.7431DOI Listing
December 2007

The effects of methylmercury on motor activity are sex- and age-dependent, and modulated by genetic deletion of adenosine receptors and caffeine administration.

Toxicology 2007 Nov 31;241(3):119-33. Epub 2007 Aug 31.

Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.tox.2007.08.092DOI Listing
November 2007

Adenosine dysfunction in astrogliosis: cause for seizure generation?

Neuron Glia Biol 2007 Nov;3(4):353-66

1RS Dow Neurobiology Laboratories, Legacy Research, Portland, OR 97232, USA.

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http://dx.doi.org/10.1017/S1740925X0800015XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561997PMC
November 2007

Modulation of glial cell functions by adenosine receptors.

Physiol Behav 2007 Sep 21;92(1-2):15-20. Epub 2007 May 21.

Karolinska Institute, Department of Physiology and Pharmacology, Section of Molecular Pharmacology, Nanna Svartz väg 2, S-171 77 Stockholm, Sweden.

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http://linkinghub.elsevier.com/retrieve/pii/S003193840700225
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http://dx.doi.org/10.1016/j.physbeh.2007.05.031DOI Listing
September 2007

A1 adenosine receptors play an essential role in protecting the embryo against hypoxia.

Proc Natl Acad Sci U S A 2007 Jun 23;104(23):9697-702. Epub 2007 May 23.

Section of Developmental Endocrinology and Biology, Yale Child Health Research Center, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1073/pnas.0703557104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1887547PMC
June 2007

Toxic effects of cobalt in primary cultures of mouse astrocytes. Similarities with hypoxia and role of HIF-1alpha.

Biochem Pharmacol 2007 Mar 17;73(5):694-708. Epub 2006 Nov 17.

Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bcp.2006.11.008DOI Listing
March 2007

NMDA depresses glutamatergic synaptic transmission in the striatum through the activation of adenosine A1 receptors: evidence from knockout mice.

Neuropharmacology 2006 Aug 18;51(2):272-82. Epub 2006 May 18.

The Karolinska Institute, Department of Physiology and Pharmacology, Section of Molecular Neurophysiology, Von Eulers Väg 8, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neuropharm.2006.03.025DOI Listing
August 2006

Effect of acute and chronic administration of caffeine on pain-like behaviors in rats with partial sciatic nerve injury.

Neurosci Lett 2006 Jul 27;402(1-2):164-6. Epub 2006 Apr 27.

Section of Clinical Neurophysiology, Karolinska University Hospital-Huddinge, Karolinska Institutet, S-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neulet.2006.03.065DOI Listing
July 2006

Adenosine A1 receptors are crucial in keeping an epileptic focus localized.

Exp Neurol 2006 Jul 5;200(1):184-90. Epub 2006 Jun 5.

Institute of Pharmacology and Toxicology, University of Zurich, CH-8057 Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.expneurol.2006.02.133DOI Listing
July 2006

Influence of the adenosine A1 receptor on blood pressure regulation and renin release.

Am J Physiol Regul Integr Comp Physiol 2006 May 15;290(5):R1324-9. Epub 2005 Dec 15.

Dept. of Medical Cell Biology, Division of Integrative Physiology, Uppsala Univ., S-751 23 Uppsala, Sweden.

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http://dx.doi.org/10.1152/ajpregu.00313.2005DOI Listing
May 2006

Effect of modulating cardiac A1 adenosine receptor expression on protection with ischemic preconditioning.

Am J Physiol Heart Circ Physiol 2006 Apr 18;290(4):H1469-73. Epub 2005 Nov 18.

Dept. of Pediatrics, University of Virginia Health System, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1152/ajpheart.00181.2005DOI Listing
April 2006

Activation and inhibition of human muscular and neuronal nicotinic acetylcholine receptors by succinylcholine.

Anesthesiology 2006 Apr;104(4):724-33

Department of Anesthesiology and Intensive Care Medicine, Karolinska University Hospital and Karolinska Institutet, Sweden.

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http://dx.doi.org/10.1097/00000542-200604000-00017DOI Listing
April 2006

Combination of adenosine A1 and A2A receptor blocking agents induces caffeine-like locomotor stimulation in mice.

Eur Neuropsychopharmacol 2006 Feb 28;16(2):129-36. Epub 2005 Jul 28.

Department of Neuroscience, Karolinska Institutet, Sweden.

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http://dx.doi.org/10.1016/j.euroneuro.2005.07.001DOI Listing
February 2006

Adenosine-dopamine interactions revealed in knockout mice.

J Mol Neurosci 2005 ;26(2-3):239-44

Department of Physiology and Pharmacology, Karolinska Institutet, SE-17177 Stockholm, Sweden.

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http://dx.doi.org/10.1385/JMN:26:2-3:239DOI Listing
October 2005

Susceptibility of the developing brain to acute hypoglycemia involving A1 adenosine receptor activation.

Am J Physiol Endocrinol Metab 2005 Oct;289(4):E562-9

Section of Developmental Endocrinology and Biology, Yale Child Health Research Center, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1152/ajpendo.00112.2005DOI Listing
October 2005

Evidence against adenosine analogues being agonists at the growth hormone secretagogue receptor.

Biochem Pharmacol 2005 Aug;70(4):598-605

Department of Physiology and Pharmacology, Section of Molecular Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bcp.2005.05.023DOI Listing
August 2005

Mice lacking the adenosine A1 receptor have normal spatial learning and plasticity in the CA1 region of the hippocampus, but they habituate more slowly.

Synapse 2005 Jul;57(1):8-16

Medical Psychology Unit, Department of Psychiatry and Forensic Medicine, Institute of Neuroscience, Autonomous University of Barcelona, 08193 Bellaterra, Barcelona, Spain.

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http://dx.doi.org/10.1002/syn.20146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213905PMC
July 2005

Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine.

Nat Neurosci 2005 Jul;8(7):858-9

Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565-0874, Japan.

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http://dx.doi.org/10.1038/nn1491DOI Listing
July 2005

Luminal adenosine stimulates chloride secretion through A1 receptor in mouse jejunum.

Am J Physiol Gastrointest Liver Physiol 2005 May 6;288(5):G972-7. Epub 2005 Jan 6.

Department of Cell Physiology, Free University of Brussels, Brussels, Germany.

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http://www.physiology.org/doi/10.1152/ajpgi.00346.2004
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http://dx.doi.org/10.1152/ajpgi.00346.2004DOI Listing
May 2005

Adenosine and brain function.

Int Rev Neurobiol 2005 ;63:191-270

Department of Physiology and Pharmacology, Karolinska Institutet Stockholm, Sweden.

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http://dx.doi.org/10.1016/S0074-7742(05)63007-3DOI Listing
May 2005

Actions of adenosine at its receptors in the CNS: insights from knockouts and drugs.

Annu Rev Pharmacol Toxicol 2005 ;45:385-412

Department of Physiology and Pharmacology, Karolinska Institutet, S-17177 Stockholm, Sweden.

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http://www.annualreviews.org/doi/10.1146/annurev.pharmtox.45
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http://dx.doi.org/10.1146/annurev.pharmtox.45.120403.095731DOI Listing
May 2005

Increased nociceptive response in mice lacking the adenosine A1 receptor.

Pain 2005 Feb;113(3):395-404

Department of Neurotec, Division of Clinical Neurophysiology, Karolinska Institutet, Karolinska University Hospital-Huddinge, S-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.pain.2004.11.020DOI Listing
February 2005

Involvement of A1 adenosine receptors in the acquisition of fertilizing capacity.

J Androl 2004 Mar-Apr;25(2):286-92

Dipartimento di Scienze Biochimiche e Biotecnologie Molecolari, Sezione Biochimica Cellulare, Perugia, Italy.

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http://dx.doi.org/10.1002/j.1939-4640.2004.tb02789.xDOI Listing
September 2004

Deletion of the adenosine A1 receptor gene does not alter neuronal damage following ischaemia in vivo or in vitro.

Eur J Neurosci 2004 Sep;20(5):1197-204

Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, Lund University, BMC A13, SE-221 84, Sweden.

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http://dx.doi.org/10.1111/j.1460-9568.2004.03564.xDOI Listing
September 2004

Neuromuscular blocking agents block carotid body neuronal nicotinic acetylcholine receptors.

Eur J Pharmacol 2004 Aug;497(2):173-80

Department of Anesthesiology and Intensive Care Medicine, Karolinska Hospital and Institute, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.ejphar.2004.06.052DOI Listing
August 2004

[Connection between caffeine, adenosine receptors and dopamine. Coffee reduces the risk of Parkinson disease].

Lakartidningen 2004 Aug;101(34):2552-5

Institutionen för fysiologi och farmakologi, Karolinska institutet, Stockholm.

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August 2004

The adenosine A1 receptor contributes to the stimulatory, but not the inhibitory effect of caffeine on locomotion: a study in mice lacking adenosine A1 and/or A2A receptors.

Neuropharmacology 2004 Jun;46(7):1008-17

Department of Physiology and Pharmacology, Section of Molecular Pharmacology, Karolinska Institutet, Nanna Svartz vag 2, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neuropharm.2004.01.014DOI Listing
June 2004

Adenosine A3 receptor-mediated regulation of p38 and extracellular-regulated kinase ERK1/2 via phosphatidylinositol-3'-kinase.

Biochem Pharmacol 2004 Jan;67(1):129-34

Department of Physiology and Pharmacology, Section of Molecular Pharmacology, Karolinska Institutet, S-171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bcp.2003.08.031DOI Listing
January 2004

Sleep and its homeostatic regulation in mice lacking the adenosine A1 receptor.

J Sleep Res 2003 Dec;12(4):283-90

Institute of Biomedicine/Physiology, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1046/j.0962-1105.2003.00367.xDOI Listing
December 2003

Adenosine-dopamine interactions: development of a concept and some comments on therapeutic possibilities.

Neurology 2003 Dec;61(11 Suppl 6):S5-9

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1212/01.wnl.0000095204.89871.ffDOI Listing
December 2003

Exciting news about A2A receptors.

Neurology 2003 Dec;61(11 Suppl 6):S10-1

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1212/01.wnl.0000095203.52609.6aDOI Listing
December 2003

The G(s)-coupled adenosine A(2B) receptor recruits divergent pathways to regulate ERK1/2 and p38.

Exp Cell Res 2003 Oct;290(1):168-76

Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/s0014-4827(03)00324-0DOI Listing
October 2003

Signalling from adenosine receptors to mitogen-activated protein kinases.

Cell Signal 2003 Sep;15(9):813-27

Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1016/s0898-6568(03)00058-5DOI Listing
September 2003

A1 adenosine receptors mediate hypoxia-induced ventriculomegaly.

Proc Natl Acad Sci U S A 2003 Sep 15;100(20):11718-22. Epub 2003 Sep 15.

Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1073/pnas.1931975100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC208824PMC
September 2003

Evidence for functional adenosine A3 receptors in microglia cells.

J Neurochem 2003 Aug;86(4):1051-4

Karolinska Institutet, Department of Physiology and Pharmacology, Section of Molecular Pharmacology, Stockholm, Sweden.

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http://dx.doi.org/10.1046/j.1471-4159.2003.01919.xDOI Listing
August 2003

Pharmacology of adenosine A2A receptors and therapeutic applications.

Curr Top Med Chem 2003 ;3(4):413-26

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.2174/1568026033392200DOI Listing
July 2003

Adenosine A 2B receptors modulate cAMP levels and induce CREB but not ERK1/2 and p38 phosphorylation in rat skeletal muscle cells.

Biochem Biophys Res Commun 2003 Jul;307(1):180-7

Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sports Sciences, August Krogh Institute, Copenhagen University, Universitetsparken 13, Copenhagen Ø, DK-2100, Denmark.

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http://dx.doi.org/10.1016/s0006-291x(03)01125-2DOI Listing
July 2003

Synergistic effects of adenosine A1 and P2Y receptor stimulation on calcium mobilization and PKC translocation in DDT1 MF-2 cells.

Cell Mol Neurobiol 2003 Jun;23(3):379-400

Department of Physiology and Pharmacology, Section of Molecular Neuropharmacology, Karolinska Institute, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1023/a:1023644822539DOI Listing
June 2003

Adenosine receptors as targets for drug development.

Drug News Perspect 2003 Jun;16(5):283-9

Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1358/dnp.2003.16.5.829316DOI Listing
June 2003

Aggravated brain damage after hypoxic ischemia in immature adenosine A2A knockout mice.

Stroke 2003 Mar 27;34(3):739-44. Epub 2003 Feb 27.

Department of Physiology and Pharmacology, Karolinska Institutet, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1161/01.STR.0000060204.67672.8BDOI Listing
March 2003

Signaling pathway from the human adenosine A(3) receptor expressed in Chinese hamster ovary cells to the extracellular signal-regulated kinase 1/2.

Mol Pharmacol 2002 Nov;62(5):1137-46

Section of Molecular Neuropharmacology, Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1124/mol.62.5.1137DOI Listing
November 2002