Bertil Abrahamsson

Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network.

Adv Drug Deliv Rev 2021 Feb 18. Epub 2021 Feb 18.

Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium. Electronic address:

February 2021

Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Carbamazepine.

Authors:

Mauricio A García Rodrigo Cristofoletti Bertil Abrahamsson Dirk W Groot Alan Parr James E Polli Mehul Mehta Vinod P Shah Tajiri Tomakazu Jennifer B Dressman Peter Langguth

J Pharm Sci 2021 Feb 18. Epub 2021 Feb 18.

Pharmaceutical Technology and Biopharmaceutics, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany. Electronic address:

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February 2021

Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Metformin Hydrochloride.

Authors:

Melissa Metry Yan Shu Bertil Abrahamsson Rodrigo Cristofoletti Jennifer B Dressman D W Groot Alan Parr Peter Langguth Vinod P Shah Tomokazu Tajiri Mehul U Mehta James E Polli

J Pharm Sci 2021 Jan 13. Epub 2021 Jan 13.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, USA. Electronic address:

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January 2021

In Vitro and In Vivo Evaluation of 3D Printed Capsules with Pressure Triggered Release Mechanism for Oral Peptide Delivery.

Authors:

Staffan Berg Julius Krause Anders Björkbom Katrin Walter Said Harun Andreas Granfeldt David Janzén Sandro Filipe Nunes Malin Antonsson Natalie Van Zuydam Stanko Skrtic Andreas Hugerth Werner Weitschies Nigel Davies Bertil Abrahamsson Christel A S Bergström

J Pharm Sci 2021 01 17;110(1):228-238. Epub 2020 Nov 17.

The Swedish Drug Delivery Center, Department of Pharmacy, Uppsala University, BMC P.O. Box 580, SE-751 23 Uppsala, Sweden. Electronic address:

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January 2021

Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: History, methodology and applications.

Authors:

Patrick Augustijns Maria Vertzoni Christos Reppas Peter Langguth Hans Lennernäs Bertil Abrahamsson William L Hasler Jason R Baker Tim Vanuytsel Jan Tack Maura Corsetti Marival Bermejo Paulo Paixão Gordon L Amidon Bart Hens

Eur J Pharm Sci 2020 Dec 18;155:105517. Epub 2020 Aug 18.

Drug delivery & Disposition, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven Herestraat 49, box 921, 3000 Leuven, Belgium. Electronic address:

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December 2020

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 4: Prediction accuracy and software comparisons with improved data and modelling strategies.

Authors:

Amais Ahmad Xavier Pepin Leon Aarons Yuya Wang Adam S Darwich J Matthew Wood Christer Tannergren Eva Karlsson Claire Patterson Helena Thörn Linette Ruston Alex Mattinson Sara Carlert Staffan Berg Donal Murphy Helena Engman Johanna Laru Richard Barker Talia Flanagan Bertil Abrahamsson Shanoo Budhdeo Frans Franek Andrea Moir Gunilla Hanisch Shriram M Pathak David Turner Masoud Jamei Jonathan Brown David Good Shruthi Vaidhyanathan Claire Jackson Olivier Nicolas Stephane Beilles Jean-Flaubert Nguefack Guillaume Louit Louis Henrion Celine Ollier Laurent Boulu Christine Xu Tycho Heimbach Xiojun Ren Wen Lin Anh-Thu Nguyen-Trung Jin Zhang Handan He Fan Wu Michael B Bolger James M Mullin Bill van Osdol Ke Szeto Timo Korjamo Sari Pappinen Johanna Tuunainen Wei Zhu Binfeng Xia Pierre Daublain Suet Wong Manthena V S Varma Sweta Modi Kerstin Julia Schäfer Kartrin Schmid Richard Lloyd Aarti Patel Christophe Tistaert Jan Bevernage Mai Anh Nguyen David Lindley Robert Carr Amin Rostami-Hodjegan

Eur J Pharm Biopharm 2020 Nov 14;156:50-63. Epub 2020 Aug 14.

University of Manchester, United Kingdom; Certara, Simcyp Division, United Kingdom.

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November 2020

Current status and future opportunities for incorporation of dissolution data in PBPK modeling for pharmaceutical development and regulatory applications: OrBiTo consortium commentary.

Authors:

Masoud Jamei Bertil Abrahamsson Jonathan Brown Jan Bevernage Michael B Bolger Tycho Heimbach Eva Karlsson Evangelos Kotzagiorgis Anders Lindahl Mark McAllister James M Mullin Xavier Pepin Christophe Tistaert David B Turner Filippos Kesisoglou

Eur J Pharm Biopharm 2020 Oct 8;155:55-68. Epub 2020 Aug 8.

Pharmaceutical Sciences, Merck & Co., Inc., Kenilworth, NJ, USA.

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October 2020

Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Moxifloxacin Hydrochloride.

Authors:

Naseem A Charoo Daud B Abdallah Thahera Parveen Bertil Abrahamsson Rodrigo Cristofoletti Dirk W Groot Peter Langguth Alan Parr James E Polli Mehul Mehta Vinod P Shah Tomokazu Tajiri Jennifer Dressman

J Pharm Sci 2020 09 12;109(9):2654-2675. Epub 2020 Jun 12.

Fraunhofer IME & Institute of Pharmaceutical Technology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany. Electronic address:

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September 2020

Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Cephalexin Monohydrate.

Authors:

Gerlinde F Plöger Paul M Quizon Bertil Abrahamsson Rodrigo Cristofoletti Dirk W Groot Alan Parr Peter Langguth James E Polli Vinod P Shah Tomokazu Tajiri Mehul U Mehta Jennifer Dressman

J Pharm Sci 2020 06 30;109(6):1846-1862. Epub 2020 Mar 30.

Institute of Pharmaceutical Technology, Goethe University, Frankfurt am Main, Germany; Fraunhofer IME, Frankfurt, Germany. Electronic address:

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June 2020

Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Ondansetron.

Authors:

Gopal Singh Rajawat Tejashree Belubbi Mangal S Nagarsenker Bertil Abrahamsson Rodrigo Cristofoletti Dirk W Groot Peter Langguth Alan Parr James E Polli Mehul Mehta Vinod P Shah Tomokazu Tajiri Jennifer Dressman

J Pharm Sci 2019 10 8;108(10):3157-3168. Epub 2019 Jun 8.

Institute of Pharmaceutical Technology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany. Electronic address:

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October 2019

Nanofibrous Scaffolds Support a 3D Permeability Model of the Human Intestinal Epithelium.

Authors:

Jamie D Patient Hadi Hajiali Kate Harris Bertil Abrahamsson Christer Tannergren Lisa J White Amir M Ghaemmaghami Philip M Williams Clive J Roberts Felicity R A J Rose

Front Pharmacol 2019 10;10:456. Epub 2019 May 10.

School of Pharmacy, University of Nottingham, Nottingham, United Kingdom.

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May 2019

Effect of lipids on absorption of carvedilol in dogs: Is coadministration of lipids as efficient as a lipid-based formulation?

Authors:

Linda C Alskär Albin Parrow Janneke Keemink Pernilla Johansson Bertil Abrahamsson Christel A S Bergström

J Control Release 2019 06 29;304:90-100. Epub 2019 Apr 29.

Department of Pharmacy, Uppsala University, Uppsala Biomedical Center, P.O Box 580, SE-751 23 Uppsala, Sweden. Electronic address:

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June 2019

Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Proguanil Hydrochloride.

Authors:

Gerlinde F Plöger Bertil Abrahamsson Rodrigo Cristofoletti Dirk W Groot Peter Langguth Mehul U Mehta Alan Parr James E Polli Vinod P Shah Tomokazu Tajiri Jennifer B Dressman

J Pharm Sci 2018 07 20;107(7):1761-1772. Epub 2018 Mar 20.

Institute of Pharmaceutical Technology, Goethe University, Frankfurt am Main, Germany. Electronic address:

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July 2018

Regional Intestinal Permeability in Rats: A Comparison of Methods.

Authors:

Carl Roos David Dahlgren Erik Sjögren Christer Tannergren Bertil Abrahamsson Hans Lennernäs

Mol Pharm 2017 12 5;14(12):4252-4261. Epub 2017 Oct 5.

Department of Pharmacy, Uppsala University , Box 580, 751 23 Uppsala, Sweden.

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December 2017

Biowaiver Monographs for Immediate-Release Solid Oral Dosage Forms: Folic Acid.

Authors:

Martin A Hofsäss Jacqueline de Souza Neila M Silva-Barcellos Karime R Bellavinha Bertil Abrahamsson Rodrigo Cristofoletti D W Groot Alan Parr Peter Langguth James E Polli Vinod P Shah Tomokazu Tajiri Mehul U Mehta Jennifer B Dressman

J Pharm Sci 2017 12 24;106(12):3421-3430. Epub 2017 Aug 24.

Institute of Pharmaceutical Technology, Goethe University, Frankfurt am Main, Germany. Electronic address:

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December 2017

In Vivo Mechanisms of Intestinal Drug Absorption from Aprepitant Nanoformulations.

Authors:

Carl Roos David Dahlgren Staffan Berg Jan Westergren Bertil Abrahamsson Christer Tannergren Erik Sjögren Hans Lennernäs

Mol Pharm 2017 12 10;14(12):4233-4242. Epub 2017 Aug 10.

Department of Pharmacy, Uppsala University , 752 36 Uppsala, Sweden.

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December 2017

Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Amoxicillin Trihydrate.

Authors:

Dhanusha Thambavita Priyadarshani Galappatthy Uthpali Mannapperuma Lal Jayakody Rodrigo Cristofoletti Bertil Abrahamsson Dirk W Groot Peter Langguth Mehul Mehta Alan Parr James E Polli Vinod P Shah Jennifer Dressman

J Pharm Sci 2017 10 5;106(10):2930-2945. Epub 2017 May 5.

Institute of Pharmaceutical Technology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany. Electronic address:

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October 2017

Biowaiver Monographs for Immediate-Release Solid Oral Dosage Forms: Enalapril.

Authors:

Roger K Verbeeck Isadore Kanfer Raimar Löbenberg Bertil Abrahamsson Rodrigo Cristofoletti D W Groot Peter Langguth James E Polli Alan Parr Vinod P Shah Mehul Mehta Jennifer B Dressman

J Pharm Sci 2017 08 21;106(8):1933-1943. Epub 2017 Apr 21.

Institute of Pharmaceutical Technology, Goethe University, Frankfurt am Main, Germany. Electronic address:

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August 2017

Amorphous is not always better-A dissolution study on solid state forms of carbamazepine.

Authors:

Linda G Jensen Frederik B Skautrup Anette Müllertz Bertil Abrahamsson Thomas Rades Petra A Priemel

Int J Pharm 2017 Apr 2;522(1-2):74-79. Epub 2017 Mar 2.

University of Copenhagen, School of Pharmaceutical Sciences, Denmark.

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April 2017

Biopharmaceutics data management system for anonymised data sharing and curation: First application with orbito IMI project.

Authors:

Kristin Lacy-Jones Philip Hayward Steve Andrews Ian Gledhill Mark McAllister Bertil Abrahamsson Amin Rostami-Hodjegan Xavier Pepin

Comput Methods Programs Biomed 2017 Mar 18;140:29-44. Epub 2016 Nov 18.

AstraZeneca Global Operations, Pharmaceutical Technology and Development Silk Road Business Park, Charter Way, Macclesfield, SK10 2NA, England.

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March 2017

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results.

Authors:

Alison Margolskee Adam S Darwich Xavier Pepin Leon Aarons Aleksandra Galetin Amin Rostami-Hodjegan Sara Carlert Maria Hammarberg Constanze Hilgendorf Pernilla Johansson Eva Karlsson Dónal Murphy Christer Tannergren Helena Thörn Mohammed Yasin Florent Mazuir Olivier Nicolas Sergej Ramusovic Christine Xu Shriram M Pathak Timo Korjamo Johanna Laru Jussi Malkki Sari Pappinen Johanna Tuunainen Jennifer Dressman Simone Hansmann Edmund Kostewicz Handan He Tycho Heimbach Fan Wu Carolin Hoft Loic Laplanche Yan Pang Michael B Bolger Eva Huehn Viera Lukacova James M Mullin Ke X Szeto Chester Costales Jian Lin Mark McAllister Sweta Modi Charles Rotter Manthena Varma Mei Wong Amitava Mitra Jan Bevernage Jeike Biewenga Achiel Van Peer Richard Lloyd Carole Shardlow Peter Langguth Irina Mishenzon Mai Anh Nguyen Jonathan Brown Hans Lennernäs Bertil Abrahamsson

Eur J Pharm Sci 2017 Jan 2;96:610-625. Epub 2016 Nov 2.

AstraZeneca, Sweden.

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January 2017

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes.

Authors:

Adam S Darwich Alison Margolskee Xavier Pepin Leon Aarons Aleksandra Galetin Amin Rostami-Hodjegan Sara Carlert Maria Hammarberg Constanze Hilgendorf Pernilla Johansson Eva Karlsson Dónal Murphy Christer Tannergren Helena Thörn Mohammed Yasin Florent Mazuir Olivier Nicolas Sergej Ramusovic Christine Xu Shriram M Pathak Timo Korjamo Johanna Laru Jussi Malkki Sari Pappinen Johanna Tuunainen Jennifer Dressman Simone Hansmann Edmund Kostewicz Handan He Tycho Heimbach Fan Wu Carolin Hoft Yan Pang Michael B Bolger Eva Huehn Viera Lukacova James M Mullin Ke X Szeto Chester Costales Jian Lin Mark McAllister Sweta Modi Charles Rotter Manthena Varma Mei Wong Amitava Mitra Jan Bevernage Jeike Biewenga Achiel Van Peer Richard Lloyd Carole Shardlow Peter Langguth Irina Mishenzon Mai Anh Nguyen Jonathan Brown Hans Lennernäs Bertil Abrahamsson

Eur J Pharm Sci 2017 Jan 28;96:626-642. Epub 2016 Sep 28.

AstraZeneca, Sweden.

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January 2017

IMI - oral biopharmaceutics tools project - evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds.

Eur J Pharm Sci 2017 Jan 23;96:598-609. Epub 2016 Sep 23.

AstraZeneca, Sweden.

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January 2017

Regional Intestinal Permeability of Three Model Drugs in Human.

Authors:

David Dahlgren Carl Roos Anders Lundqvist Bertil Abrahamsson Christer Tannergren Per M Hellström Erik Sjögren Hans Lennernäs

Mol Pharm 2016 09 18;13(9):3013-21. Epub 2016 Aug 18.

Department of Pharmacy, Uppsala University , Uppsala SE-751 23, Sweden.

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September 2016

Regional Intestinal Permeability in Dogs: Biopharmaceutical Aspects for Development of Oral Modified-Release Dosage Forms.

Authors:

David Dahlgren Carl Roos Pernilla Johansson Anders Lundqvist Christer Tannergren Bertil Abrahamsson Erik Sjögren Hans Lennernäs

Mol Pharm 2016 09 18;13(9):3022-33. Epub 2016 Aug 18.

Department of Pharmacy, Uppsala University , Uppsala SE-751 23, Sweden.

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September 2016

A Novel Disintegration Tester for Solid Dosage Forms Enabling Adjustable Hydrodynamics.

Authors:

Sarah Kindgen Regine Rach Thomas Nawroth Bertil Abrahamsson Peter Langguth

J Pharm Sci 2016 08 13;105(8):2402-9. Epub 2016 Jul 13.

Department of Pharmaceutical Technology and Biopharmaceutics, Johannes Gutenberg University, Staudingerweg 5, 55128 Mainz, Germany. Electronic address:

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August 2016

Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ribavirin.

Authors:

Navid Goodarzi Ahmadreza Barazesh Morgani Bertil Abrahamsson Rodrigo Cristofoletti D W Groot Peter Langguth Mehul U Mehta James E Polli Vinod P Shah Jennifer B Dressman

J Pharm Sci 2016 Apr 5;105(4):1362-9. Epub 2016 Mar 5.

Institute of Pharmaceutical Technology, Goethe University, Frankfurt am Main, Germany. Electronic address:

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April 2016

Effect of food intake and co-administration of placebo self-nanoemulsifying drug delivery systems on the absorption of cinnarizine in healthy human volunteers.

Authors:

Martin Lau Christiansen Rene Holm Bertil Abrahamsson Jette Jacobsen Jakob Kristensen Jens Rikardt Andersen Anette Müllertz

Eur J Pharm Sci 2016 Mar 14;84:77-82. Epub 2016 Jan 14.

University of Copenhagen, Faculty of Health and Medical Sciences, Universitetsparken 2, 2100 Copenhagen, Denmark; Bioneer:FARMA, Department of Pharmacy, University of Copenhagen.

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March 2016