Berta Strulovici

A multiplexed siRNA screening strategy to identify genes in the PARP pathway.

Authors:

Erica Stec Louis Locco Stacey Szymanski Steven R Bartz Carlo Toniatti Rachel H V Needham Anthony Palmieri Michael Carleton Michele A Cleary Aimee L Jackson Peter S Linsley Berta Strulovici Marc Ferrer Francesca Santini

J Biomol Screen 2012 Dec 10;17(10):1316-28. Epub 2012 Jul 10.

Department of Automated Biotechnology, Merck, North Wales, PA 19454, USA.

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December 2012

Induced pluripotent stem cells--opportunities for disease modelling and drug discovery.

Authors:

Marica Grskovic Ashkan Javaherian Berta Strulovici George Q Daley

Nat Rev Drug Discov 2011 Nov 11;10(12):915-29. Epub 2011 Nov 11.

iPierian, 951 Gateway Blvd, South San Francisco, California 94080, USA.

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November 2011

A 1,536-well ultra-high-throughput siRNA screen to identify regulators of the Wnt/beta-catenin pathway.

Authors:

Namjin Chung Shane Marine Emily A Smith Robert Liehr S Todd Smith Louis Locco Edward Hudak Anthony Kreamer Alison Rush Brian Roberts Michael B Major Randall T Moon William Arthur Michele Cleary Berta Strulovici Marc Ferrer

Assay Drug Dev Technol 2010 Jun;8(3):286-94

Department of Automated Biotechnology, Merck & Co., North Wales, Pennsylvania, USA.

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June 2010

Identification of small-molecule modulators of mouse SVZ progenitor cell proliferation and differentiation through high-throughput screening.

Authors:

Yaping Liu Raul Lacson Jason Cassaday David A Ross Anthony Kreamer Edward Hudak Richard Peltier Donna McLaren Ignacio Muñoz-Sanjuan Francesca Santini Berta Strulovici Marc Ferrer

J Biomol Screen 2009 Apr;14(4):319-29

Department of Automated Biotechnology, Merck & Co., North Wales, Pennsylvania 19454, USA.

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April 2009

Genome-scale RNAi screen for host factors required for HIV replication.

Authors:

Honglin Zhou Min Xu Qian Huang Adam T Gates Xiaohua D Zhang John C Castle Erica Stec Marc Ferrer Berta Strulovici Daria J Hazuda Amy S Espeseth

Cell Host Microbe 2008 Nov 30;4(5):495-504. Epub 2008 Oct 30.

Department of Virus and Cell Biology, Merck & Co., Inc., West Point, PA 19486, USA.

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November 2008

Current trends in high-throughput screening.

Authors:

John Sterling Dejan Bojanic Richard M Eglen Stephan Heyse Berta Strulovici

Assay Drug Dev Technol 2008 Aug;6(4):491-504

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August 2008

Hit selection with false discovery rate control in genome-scale RNAi screens.

Authors:

Xiaohua Douglas Zhang Pei Fen Kuan Marc Ferrer Xiaohua Shu Yingxue C Liu Adam T Gates Priya Kunapuli Erica M Stec Min Xu Shane D Marine Daniel J Holder Berta Strulovici Joseph F Heyse Amy S Espeseth

Nucleic Acids Res 2008 Aug 15;36(14):4667-79. Epub 2008 Jul 15.

Biometrics Research, Merck Research Laboratories, West Point, PA 19486, USA.

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August 2008

A 1,536-well [(35)S]GTPgammaS scintillation proximity binding assay for ultra-high-throughput screening of an orphan galphai-coupled GPCR.

Authors:

Eric N Johnson Xiaoqing Shi Jason Cassaday Marc Ferrer Berta Strulovici Priya Kunapuli

Assay Drug Dev Technol 2008 Jun;6(3):327-37

Department of Automated Biotechnology, Merck Research Laboratories, North Wales, PA 19454, USA.

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June 2008

Integrating experimental and analytic approaches to improve data quality in genome-wide RNAi screens.

Authors:

Xiaohua Douglas Zhang Amy S Espeseth Eric N Johnson Jayne Chin Adam Gates Lyndon J Mitnaul Shane D Marine Jenny Tian Eric M Stec Priya Kunapuli Dan J Holder Joseph F Heyse Berta Strulovici Marc Ferrer

J Biomol Screen 2008 Jun 14;13(5):378-89. Epub 2008 May 14.

Biometrics Research, Merck Research Laboratories, West Point, Pennsylvania 19486, USA.

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June 2008

Miniaturization and HTS of a FRET-based membrane potential assay for K(ir) channel inhibitors.

Authors:

Kelli Solly Jason Cassaday John P Felix Maria L Garcia Marc Ferrer Berta Strulovici Laszlo Kiss

Assay Drug Dev Technol 2008 Apr;6(2):225-34

Automated Biotechnology, Merck Research Laboratories, North Wales, PA 19454, USA.

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April 2008

A fluorescence-based thiol quantification assay for ultra-high-throughput screening for inhibitors of coenzyme A production.

Authors:

Christine C Chung Kenji Ohwaki Jonathan E Schneeweis Erica Stec Jeffrey P Varnerin Paul N Goudreau Amy Chang Jason Cassaday Lihu Yang Takeru Yamakawa Oleg Kornienko Peter Hodder James Inglese Marc Ferrer Berta Strulovici Jun Kusunoki Michael R Tota Toshimitsu Takagi

Assay Drug Dev Technol 2008 Jun;6(3):361-74

Department of Metabolic Disorders, Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ, USA.

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June 2008

Median absolute deviation to improve hit selection for genome-scale RNAi screens.

Authors:

Namjin Chung Xiaohua Douglas Zhang Anthony Kreamer Louis Locco Pei-Fen Kuan Steven Bartz Peter S Linsley Marc Ferrer Berta Strulovici

J Biomol Screen 2008 Feb 23;13(2):149-58. Epub 2008 Jan 23.

Department of Automated Biotechnology, Merck Research Laboratories, North Wales, PA 19454, USA.

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February 2008

An efficient and fully automated high-throughput transfection method for genome-scale siRNA screens.

Authors:

Namjin Chung Louis Locco Kevin W Huff Steven Bartz Peter S Linsley Marc Ferrer Berta Strulovici

J Biomol Screen 2008 Feb 23;13(2):142-8. Epub 2008 Jan 23.

Department of Automated Biotechnology, Merck Research Laboratories, North Wales, PA 19454, USA.

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February 2008

Miniaturization and automation of an ubiquitin ligase cascade enzyme-linked immunosorbent assay in 1,536-well format.

Authors:

Jason Cassaday Tarak Shah Justin Murray Gregory T O'Donnell Oleg Kornienko Berta Strulovici Marc Ferrer Paul Zuck

Assay Drug Dev Technol 2007 Aug;5(4):493-500

Department of Automated Biotechnology, Merck Research Laboratories, North Wales, PA 19454, USA.

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August 2007

A high-precision fluorogenic cholesteryl ester transfer protein assay compatible with animal serum and 3456-well assay technology.

Authors:

Suzanne S Eveland Denise P Milot Qiu Guo Ying Chen Sheryl A Hyland Laurence B Peterson Sylvie Jezequel-Sur Gregory T O'Donnell Paul D Zuck Marc Ferrer Berta Strulovici John A Wagner Wesley K Tanaka Deborah A Hilliard Omar Laterza Samuel D Wright Carl P Sparrow Matt S Anderson

Anal Biochem 2007 Sep 8;368(2):239-49. Epub 2007 Jun 8.

Department of Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA.

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September 2007

The use of strictly standardized mean difference for hit selection in primary RNA interference high-throughput screening experiments.

Authors:

Xiaohua Douglas Zhang Marc Ferrer Amy S Espeseth Shane Douglas Marine Erica M Stec Michael A Crackower Daniel J Holder Joseph F Heyse Berta Strulovici

J Biomol Screen 2007 Jun 13;12(4):497-509. Epub 2007 Apr 13.

Biometrics Research, Merck Research Laboratories, West Point, Pennsylvania 19486, USA. xiaohua_zhang

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June 2007

Ultra-high-throughput screening for antagonists of a Gi-coupled receptor in a 2.2-microl 3,456-well plate format cyclicAMP assay.

Authors:

Michael Weber Lalitha Muthusubramaniam Justin Murray Ed Hudak Oleg Kornienko Eric N Johnson Berta Strulovici Priya Kunapuli

Assay Drug Dev Technol 2007 Feb;5(1):117-25

Department of Automated Biotechnology, Merck Research Laboratories, North Wales, PA 19454, USA.

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February 2007

LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease.

Proc Natl Acad Sci U S A 2006 Nov 10;103(47):17967-72. Epub 2006 Nov 10.

Department of Alzheimer's Research, Merck & Co., Inc., West Point, PA 19486, USA.

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November 2006

Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions.

Mol Cell Biol 2006 Dec 25;26(24):9377-86. Epub 2006 Sep 25.

Rosetta Inpharmatics, LLC, Seattle, WA 98109, USA.

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December 2006

A miniaturized cell-based fluorescence resonance energy transfer assay for insulin-receptor activation.

Authors:

Shane Marine Elize Zamiara S Todd Smith Erica M Stec Jeremy McGarvey Oleg Kornienko Guoqiang Jiang Kenny K Wong Jeffrey H Stack Bei B Zhang Marc Ferrer Berta Strulovici

Anal Biochem 2006 Aug 9;355(2):267-77. Epub 2006 Jun 9.

Department of Automated Biotechnology, Merck & Co., Inc., 502 Louise Lane, North Wales, PA 19454, USA.

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August 2006

A cell-based ultra-high-throughput screening assay for identifying inhibitors of D-amino acid oxidase.

Authors:

Philip E Brandish Chi-Sung Chiu Jonathan Schneeweis Nicholas J Brandon Clare L Leech Oleg Kornienko Edward M Scolnick Berta Strulovici Wei Zheng

J Biomol Screen 2006 Aug 7;11(5):481-7. Epub 2006 Jun 7.

Department of Neurobiology, West Point, PA, USA.

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August 2006

Identification of small molecule antagonists of the human mas-related gene-X1 receptor.

Authors:

Priya Kunapuli Seungtaek Lee Wei Zheng Melissa Alberts Oleg Kornienko Rebecca Mull Anthony Kreamer Jong-Ik Hwang Melvin I Simon Berta Strulovici

Anal Biochem 2006 Apr 3;351(1):50-61. Epub 2006 Feb 3.

Department of Automated Biotechnology, Merck Research Laboratories, North Wales, PA 19454, USA.

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April 2006

A short-incubation reporter-gene assay for high-throughput screening of estrogen receptor-alpha antagonists.

Authors:

Xiaoqing Shi Wei Zheng Jonathan E Schneeweis Paul A Fischer Berta Strulovici Norbert T Peekhaus

Assay Drug Dev Technol 2005 Aug;3(4):393-400

Department of Automated Biotechnology, Merck Research Laboratories, North Wales, PA, USA.

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August 2005

High-throughput screening of 11beta-hydroxysteroid dehydrogenase type 1 in scintillation proximity assay format.

Authors:

Kelli Solly Steven S Mundt Hratch J Zokian Gloria Juy-Fang Ding Anne Hermanowski-Vosatka Berta Strulovici Wei Zheng

Assay Drug Dev Technol 2005 Aug;3(4):377-84

Department of Automated Biotechnology, Merck & Co., North Wales, PA, USA.

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August 2005

Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization.

Authors:

James Z Deng Daniel R McMasters Philippe M A Rabbat Peter D Williams Craig A Coburn Youwei Yan Lawrence C Kuo S Dale Lewis Bobby J Lucas Julie A Krueger Berta Strulovici Joseph P Vacca Terry A Lyle Christopher S Burgey

Bioorg Med Chem Lett 2005 Oct;15(20):4411-6

Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA.

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October 2005

Miniaturization of absorbance assays using the fluorescent properties of white microplates.

Authors:

Paul Zuck Gregory T O'Donnell Jason Cassaday Peter Chase Peter Hodder Berta Strulovici Marc Ferrer

Anal Biochem 2005 Jul;342(2):254-9

Department of Automated Biotechnology, Merck and Company, 502 Louise Lane, North Wales, PA 19454, USA.

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July 2005

Application of division arrest technology to cell-based HTS: comparison with frozen and fresh cells.

Authors:

Priya Kunapuli Wei Zheng Michael Weber Kelli Solly Rebecca Mull Michael Platchek Mei Cong Zhong Zhong Berta Strulovici

Assay Drug Dev Technol 2005 Feb;3(1):17-26

Department of Automated Biotechnology, Merck Research Laboratories, North Wales, PA 19454, USA.

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February 2005

Compounds that bind APP and inhibit Abeta processing in vitro suggest a novel approach to Alzheimer disease therapeutics.

J Biol Chem 2005 May 25;280(18):17792-7. Epub 2005 Feb 25.

Biological Chemistry, Medicinal Chemistry, and Automated Biotechnology, Merck Research Laboratories, West Point, Pennsylvania 19486, USA.

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May 2005

A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists.

Authors:

Jeffrey J Hale Christopher L Lynch William Neway Sander G Mills Richard Hajdu Carol Ann Keohane Mark J Rosenbach James A Milligan Gan-Ju Shei Stephen A Parent Gary Chrebet James Bergstrom Deborah Card Marc Ferrer Peter Hodder Berta Strulovici Hugh Rosen Suzanne Mandala

J Med Chem 2004 Dec;47(27):6662-5

Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, New Jersey 07065, USA.

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December 2004

A cell-based beta-lactamase reporter gene assay for the identification of inhibitors of hepatitis C virus replication.

Authors:

Paul Zuck Edward M Murray Erica Stec Jay A Grobler Adam J Simon Berta Strulovici James Inglese Osvaldo A Flores Marc Ferrer

Anal Biochem 2004 Nov;334(2):344-55

Department of Automated Biotechnology, Merck and Co., 502 Louise Lane., North Wales, PA 19454, USA.

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November 2004

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