Bert Vogelstein

Bert Vogelstein

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Bert Vogelstein

Bert Vogelstein

Publications by authors named "Bert Vogelstein"

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An analysis of genetic heterogeneity in untreated cancers.

Nat Rev Cancer 2019 Nov 27;19(11):639-650. Epub 2019 Aug 27.

The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/s41568-019-0185-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816333PMC
November 2019

Direct Detection and Quantification of Neoantigens.

Cancer Immunol Res 2019 Nov 16;7(11):1748-1754. Epub 2019 Sep 16.

Ludwig Center, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland.

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http://dx.doi.org/10.1158/2326-6066.CIR-19-0107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825591PMC
November 2019

Utility of CT Radiomics Features in Differentiation of Pancreatic Ductal Adenocarcinoma From Normal Pancreatic Tissue.

AJR Am J Roentgenol 2019 Aug 23;213(2):349-357. Epub 2019 Apr 23.

1 The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287.

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http://dx.doi.org/10.2214/AJR.18.20901DOI Listing
August 2019

Applications of liquid biopsies for cancer.

Sci Transl Med 2019 Aug;11(507)

Ludwig Center and the Howard Hughes Medical Institute at the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, 1650 Orleans St., CRB1, Room 520, Baltimore, MD 21128, USA.

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http://dx.doi.org/10.1126/scitranslmed.aay1984DOI Listing
August 2019

p53: a tumor suppressor hiding in plain sight.

J Mol Cell Biol 2019 Jul;11(7):536-538

Ludwig Center & Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, 1650 Orleans Street St, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1093/jmcb/mjz068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736432PMC
July 2019

On the slope of the regression between stem cell divisions and cancer risk, and the lack of correlation between stem cell divisions and environmental factors-associated cancer risk.

PLoS One 2017 16;12(5):e0175535. Epub 2017 May 16.

Ludwig Center & Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0175535PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433839PMC
February 2019

Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome.

Nature 2018 12 12;564(7735):273-277. Epub 2018 Dec 12.

Ludwig Center and the Howard Hughes Medical Institute at the Johns Hopkins Kimmel Cancer Center, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/s41586-018-0774-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512810PMC
December 2018

Cancer prevention: Molecular and epidemiologic consensus.

Science 2018 09;361(6409):1317-1318

Division of Biostatistics and Bioinformatics, Department of Oncology, Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1126/science.aau3830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260589PMC
September 2018

Deep Learning in Radiology: Now the Real Work Begins.

J Am Coll Radiol 2018 02 29;15(2):364-367. Epub 2017 Dec 29.

The Russell H. Morgan Department of Radiology and Radiologic Science, Johns Hopkins School of Medicine, Baltimore, Maryland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15461440173096
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http://dx.doi.org/10.1016/j.jacr.2017.08.007DOI Listing
February 2018

Selected reaction monitoring approach for validating peptide biomarkers.

Proc Natl Acad Sci U S A 2017 12 4;114(51):13519-13524. Epub 2017 Dec 4.

Ludwig Center, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287;

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http://dx.doi.org/10.1073/pnas.1712731114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754789PMC
December 2017

Role of stem-cell divisions in cancer risk.

Nature 2017 08;548(7666):E13-E14

Ludwig Center &Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, 1650 Orleans Street St, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1038/nature23302DOI Listing
August 2017

Bisulfite-converted duplexes for the strand-specific detection and quantification of rare mutations.

Proc Natl Acad Sci U S A 2017 05 17;114(18):4733-4738. Epub 2017 Apr 17.

Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21128;

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http://dx.doi.org/10.1073/pnas.1701382114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422780PMC
May 2017

Cancer-Associated Mutations in Endometriosis without Cancer.

N Engl J Med 2017 05;376(19):1835-1848

From the Departments of Obstetrics and Gynaecology (M.S.A., C.A., C.W., P.J.Y., D.G.H.) and Pathology and Laboratory Medicine (M.S.A., T.M.N., J. Senz, B.T.-C., C.B.G., D.G.H.), University of British Columbia, the Department of Anatomical Pathology, Vancouver General Hospital (T.M.N., H.M.H., J.H., V.L., B.T.-C., A.W., C.B.G., D.G.H.), the Department of Molecular Oncology, British Columbia Cancer Agency (H.M.H., A.L., V.L., N.B., D.G.H.), and the BC Women's Centre for Pelvic Pain and Endometriosis, BC Women's Hospital and Health Centre (F.W., N.O., C.A., C.W., P.J.Y.) - all in Vancouver, BC, Canada; the Department of Oncology (N.P., C.T., K.W.K., L.D., T.-L.W., B.V., I.-M.S.) and Ludwig Center (N.P., Y.W., J.D.C., M.Z., M.P., W.M., A.M., K.W.K., L.D., B.V.), Sidney Kimmel Comprehensive Cancer Center, the Departments of Pathology (N.P., A.A., M.N., L.D.W., T.-L.W., B.V., I.-M.S.) and Gynecology and Obstetrics (J. Segars, I.-M.S.), Johns Hopkins Medical Institutions, Personal Genome Diagnostics (S.J.), and Johns Hopkins University Howard Hughes Medical Institute (B.V.) - all in Baltimore; the Department of Pathology, Seirei Mikatahara Hospital (A.A., H.O.), and the Department of Tumor Pathology, Hamamatsu University School of Medicine (A.A.), Hamamatsu, and the Department of Molecular Pathology, Hiroshima University School of Medicine, Hiroshima (A.A.) - all in Japan; the Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands (M.N.); the Departments of Obstetrics and Gynecology (T.S.) and Pathology (R.A., A.H.), Lenox Hill Hospital-Northwell Health (Hofstra University), New York; and the Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Tao-Yuan City, Taiwan (R.-C.W.).

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http://dx.doi.org/10.1056/NEJMoa1614814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555376PMC
May 2017

Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention.

Science 2017 03;355(6331):1330-1334

Ludwig Center and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, 1650 Orleans Street, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1126/science.aaf9011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852673PMC
March 2017

Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design.

Bioorg Med Chem 2017 02 16;25(4):1481-1486. Epub 2017 Jan 16.

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319926PMC
February 2017

Necessity Is the Mother of Invention: The Development of Digital Genomics.

Clin Chem 2016 12 17;62(12):1668-1669. Epub 2016 Oct 17.

The Ludwig Center and.

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http://dx.doi.org/10.1373/clinchem.2016.262741DOI Listing
December 2016

Evaluating the evaluation of cancer driver genes.

Proc Natl Acad Sci U S A 2016 12 22;113(50):14330-14335. Epub 2016 Nov 22.

Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218;

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http://dx.doi.org/10.1073/pnas.1616440113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167163PMC
December 2016

Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing.

Proc Natl Acad Sci U S A 2016 08 15;113(35):9846-51. Epub 2016 Aug 15.

Ludwig Center for Cancer Genetics and Therapeutics, Department of Oncology, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21231.

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http://dx.doi.org/10.1073/pnas.1607794113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024639PMC
August 2016

Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer.

Sci Transl Med 2016 07;8(346):346ra92

Division of Systems Biology and Personalised Medicine, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia. Department of Medical Oncology, Western Health, St Albans, Victoria 3021, Australia. Department of Medical Oncology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria 3010, Australia. Ludwig Institute for Cancer Research, New York, NY 10017, USA.

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http://stm.sciencemag.org/content/8/346/346ra92.full.pdf
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http://dx.doi.org/10.1126/scitranslmed.aaf6219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346159PMC
July 2016

Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers.

Gastroenterology 2016 Apr 5;150(4):931-43. Epub 2016 Jan 5.

Ludwig Center at Johns Hopkins, Baltimore, Maryland; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2015.12.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270616PMC
April 2016

Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma.

Cancer Prev Res (Phila) 2016 04 9;9(4):265-74. Epub 2016 Feb 9.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland. Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute, and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland. Department of Surgery, Section of Otolaryngology-Head and Neck Surgery, The University of Chicago, Chicago, Illinois States.

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http://dx.doi.org/10.1158/1940-6207.CAPR-15-0316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818686PMC
April 2016

The Genetic Evolution of Melanoma.

N Engl J Med 2016 03;374(10):996

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http://dx.doi.org/10.1056/NEJMc1515834DOI Listing
March 2016

CEST theranostics: label-free MR imaging of anticancer drugs.

Oncotarget 2016 Feb;7(6):6369-78

F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.

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http://dx.doi.org/10.18632/oncotarget.7141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872720PMC
February 2016

Deregulation of energy metabolism promotes antifibrotic effects in human hepatic stellate cells and prevents liver fibrosis in a mouse model.

Biochem Biophys Res Commun 2016 Jan 23;469(3):463-9. Epub 2015 Oct 23.

Division of Interventional Radiology, Russell H. Morgan Department of Radiology & Radiological Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X153080
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http://dx.doi.org/10.1016/j.bbrc.2015.10.101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548097PMC
January 2016

Intraductal papillary mucinous neoplasm in a neonate with congenital hyperinsulinism and a de novo germline SKIL gene mutation.

Pancreatology 2015 Mar-Apr;15(2):194-6. Epub 2014 Oct 27.

Division of Pediatric Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.pan.2014.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387019PMC
December 2015

Lavage of the Uterine Cavity for Molecular Detection of Müllerian Duct Carcinomas: A Proof-of-Concept Study.

J Clin Oncol 2015 Dec 9;33(36):4293-300. Epub 2015 Nov 9.

Elisabeth Maritschnegg, Nina Pecha, Reinhard Horvat, Paul Speiser, and Robert Zeillinger, Medical University of Vienna, Vienna, Austria; Yuxuan Wang, Isaac Kinde, Luis A. Diaz Jr, Nickolas Papadopoulos, Kenneth W. Kinzler, and Bert Vogelstein, Johns Hopkins University, Baltimore, MD; Els Van Nieuwenhuysen and Ignace Vergote, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium; Florian Heitz, Kliniken Essen Mitte, Essen; and Jalid Sehouli, Charité Medical University, Berlin, Germany.

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http://dx.doi.org/10.1200/JCO.2015.61.3083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678180PMC
December 2015

PRINT: A Protein Bioconjugation Method with Exquisite N-terminal Specificity.

Sci Rep 2015 Dec 17;5:18363. Epub 2015 Dec 17.

The Ludwig Center for Cancer Genetics and Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1038/srep18363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683619PMC
December 2015

A combination of molecular markers and clinical features improve the classification of pancreatic cysts.

Gastroenterology 2015 Nov 4;149(6):1501-10. Epub 2015 Aug 4.

The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University, Baltimore, Maryland; Department of Surgery, The Johns Hopkins University, Baltimore, Maryland; Department of Medicine, The Johns Hopkins University, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2015.07.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782782PMC
November 2015

Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers.

Genes Dev 2015 Nov 29;29(21):2219-24. Epub 2015 Oct 29.

Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309, USA; Howard Hughes Medical Institute, University of Colorado BioFrontiers Institute, Boulder, Colorado 80309, USA; University of Colorado Comprehensive Cancer Center, Aurora, Colorado 80045, USA;

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http://dx.doi.org/10.1101/gad.269498.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647555PMC
November 2015

The Path to Cancer --Three Strikes and You're Out.

N Engl J Med 2015 Nov;373(20):1895-8

From the Ludwig Center and Howard Hughes Medical Institute, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore.

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http://dx.doi.org/10.1056/NEJMp1508811DOI Listing
November 2015

A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity.

Nature 2015 Sep 26;525(7568):261-4. Epub 2015 Aug 26.

Program for Evolutionary Dynamics, Harvard University, One Brattle Square, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nature14971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782800PMC
September 2015

Generation of MANAbodies specific to HLA-restricted epitopes encoded by somatically mutated genes.

Proc Natl Acad Sci U S A 2015 Aug 27;112(32):9967-72. Epub 2015 Jul 27.

Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21287;

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http://dx.doi.org/10.1073/pnas.1511996112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538619PMC
August 2015

Enrichment and Expansion with Nanoscale Artificial Antigen Presenting Cells for Adoptive Immunotherapy.

ACS Nano 2015 Jul 14;9(7):6861-71. Epub 2015 Jul 14.

∥Ludwig Cancer Research Center and Howard Hughes Medical Institute, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082131PMC
http://dx.doi.org/10.1021/acsnano.5b02829DOI Listing
July 2015

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency.

N Engl J Med 2015 Jun 30;372(26):2509-20. Epub 2015 May 30.

From the Swim Across America Laboratory (D.T.L., J.N.U., B.R.B., L.A.D.), Sidney Kimmel Comprehensive Cancer Center (D.T.L., J.N.U., H.W., H.K., A.D.E., A.D.S., B.S.L., N.S.A., D.L., B.B., R.C.D., D.M.P., N.P., K.W.K., S.Z., B.V., L.A.D.), Ludwig Center and Howard Hughes Medical Institute (B.R.B., A.D.S., N.P., K.W.K., S.Z., B.V., L.A.D.), and the Departments of Radiology (A.Z.) and Pathology (F.B., T.H., R.H.H., L.D.W., N.C., T.C.C., J.M.T., R.A.A., J.R.E.), Johns Hopkins University School of Medicine, Baltimore; Department of Medicine, Stanford University School of Medicine, Stanford, CA (G.A.F.); Providence Cancer Center at Providence Health and Services, Portland, OR (T.S.C.); Department of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh (J.J.L.); Bon Secours Cancer Institute, Richmond, VA (S.M.D.); Division of Medical Oncology, Ohio State University Comprehensive Cancer Center-James Cancer Center and Solove Research Institute, and Human Cancer Genetics Program, Ohio State University Comprehensive Cancer Center, Columbus (R.M.G., A.C.); and Merck, Kenilworth, NJ, and North Wales, PA (M.K.).

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http://dx.doi.org/10.1056/NEJMoa1500596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481136PMC
June 2015

Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas.

Sci Transl Med 2015 Jun;7(293):293ra104

Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute, and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa8507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587492PMC
June 2015

Familial and sporadic pancreatic cancer share the same molecular pathogenesis.

Fam Cancer 2015 Mar;14(1):95-103

Department of Pathology, The Sol Goldman Center for Pancreatic Cancer Research, Johns Hopkins University School of Medicine, Room 344, Cancer Research Building-II, 1550 Orleans Street, Baltimore, MD, 21231, USA.

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http://link.springer.com/content/pdf/10.1007/s10689-014-9755
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http://link.springer.com/10.1007/s10689-014-9755-y
Publisher Site
http://dx.doi.org/10.1007/s10689-014-9755-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357548PMC
March 2015

Clostridium novyi-NT can cause regression of orthotopically implanted glioblastomas in rats.

Oncotarget 2015 Mar;6(8):5536-46

Department of Neurology & Neurosurgery, Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467385PMC
http://dx.doi.org/10.18632/oncotarget.3627DOI Listing
March 2015

Cancer risk: role of environment—response.

Science 2015 Feb 5;347(6223):729-31. Epub 2015 Feb 5.

Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1126/science.aaa6592DOI Listing
February 2015

Only three driver gene mutations are required for the development of lung and colorectal cancers.

Proc Natl Acad Sci U S A 2015 Jan 22;112(1):118-23. Epub 2014 Dec 22.

Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205

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http://dx.doi.org/10.1073/pnas.1421839112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291633PMC
January 2015

Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions.

Science 2015 Jan;347(6217):78-81

Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, 1650 Orleans Street, Baltimore, MD 21205, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1260825
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http://dx.doi.org/10.1126/science.1260825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446723PMC
January 2015

Systemic delivery of microencapsulated 3-bromopyruvate for the therapy of pancreatic cancer.

Clin Cancer Res 2014 Dec 17;20(24):6406-17. Epub 2014 Oct 17.

Russell H. Morgan Department of Radiology and Radiological Science, Division of Vascular and Interventional Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300523PMC
December 2014

Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors.

Nat Genet 2014 Nov 12;46(11):1170-2. Epub 2014 Oct 12.

1] Ludwig Center for Cancer Genetics, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, USA. [2] Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. [3] Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/ng.3116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383254PMC
November 2014

Detection of somatic TP53 mutations in tampons of patients with high-grade serous ovarian cancer.

Obstet Gynecol 2014 Nov;124(5):881-5

Departments of Obstetrics and Gynecology and Pathology, University of Alabama at Birmingham, Birmingham, Alabama; the Ludwig Center of Cancer Genetics and Therapeutics and the Swim Across America Laboratory at Johns Hopkins University, Baltimore, Maryland; and the Departments of Obstetrics and Gynecology and Pathology, University of Virginia, Charlottesville, Virginia.

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http://dx.doi.org/10.1097/AOG.0000000000000484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316672PMC
November 2014

Activation of diverse signalling pathways by oncogenic PIK3CA mutations.

Nat Commun 2014 Sep 23;5:4961. Epub 2014 Sep 23.

1] McKusick-Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University School of Medicine, 733 North Broadway, BRB 527, Baltimore, Maryland 21205, USA [2] Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA [3] Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1038/ncomms5961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210192PMC
September 2014

Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells.

Proc Natl Acad Sci U S A 2014 Aug 28;111(32):11774-9. Epub 2014 Jul 28.

Ludwig Center for Cancer Genetics and Therapeutics, Sidney Kimmel Comprehensive Cancer Center,

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http://dx.doi.org/10.1073/pnas.1410626111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136565PMC
August 2014

Structural basis of nSH2 regulation and lipid binding in PI3Kα.

Oncotarget 2014 Jul;5(14):5198-208

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170646PMC
http://dx.doi.org/10.18632/oncotarget.2263DOI Listing
July 2014

A diaCEST MRI approach for monitoring liposomal accumulation in tumors.

J Control Release 2014 Apr 15;180:51-9. Epub 2014 Feb 15.

Russell H. Morgan Department of Radiology and Radiological Sciences, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore 21287, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore 21205, USA; Center for Nanomedicine, The Johns Hopkins University School of Medicine, Baltimore 21287, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2014.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000735PMC
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GNAS sequencing identifies IPMN-specific mutations in a subgroup of diminutive pancreatic cysts referred to as "incipient IPMNs".

Am J Surg Pathol 2014 Mar;38(3):360-3

Departments of *Pathology ††Oncology #Surgery, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine ‡Ludwig Center for Cancer Genetics **Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD §Department of Pathology, Microbiology, Immunology, Vanderbilt University Medical Center, Nashville, TN Departments of †General, Visceral, Thoracic and Vascular Surgery ¶Prostate Cancer Research ∥Institute of Pathology, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1097/PAS.0000000000000117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927228PMC
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http://dx.doi.org/10.1073/pnas.1324135111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926059PMC
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http://dx.doi.org/10.1002/gcc.22114DOI Listing
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http://dx.doi.org/10.1126/science.1246886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038033PMC
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Authors' Affiliations: The Ludwig Center for Cancer Genetics and Therapeutics, The Swim Across America Laboratory at Johns Hopkins, and The Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center; Departments of Pathology, Oncology, and Urology, The Johns Hopkins Medical Institutes, Baltimore, Maryland.

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