Bert Klebl

Bert Klebl

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Bert Klebl

Bert Klebl

Publications by authors named "Bert Klebl"

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Chemical Validation of DegS As a Target for the Development of Antibiotics with a Novel Mode of Action.

ChemMedChem 2019 Jun 24;14(11):1074-1078. Epub 2019 Apr 24.

Chemical Biology, Faculty of Biology, Center of Medical Biotechnology, University Duisburg-Essen, Universitätsstr. 2, 45117, Essen, Germany.

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http://dx.doi.org/10.1002/cmdc.201900193DOI Listing
June 2019

Dual Inhibition of GSK3β and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In Vivo.

Stem Cell Reports 2019 03 14;12(3):502-517. Epub 2019 Feb 14.

Technische Universität Dresden, DFG-Research Center for Regenerative Therapies Dresden (CRTD), Fetscherstrasse 105, 01307 Dresden, Germany; Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409486PMC
March 2019

Identification of Noncatalytic Lysine Residues from Allosteric Circuits via Covalent Probes.

ACS Chem Biol 2018 05 16;13(5):1307-1312. Epub 2018 Apr 16.

Microbiology, Faculty of Biology, Zentrum für Medizinische Biotechnologie (ZMB) , Universität Duisburg-Essen , Universitätsstr. 2 , 45117 Essen , Germany.

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http://dx.doi.org/10.1021/acschembio.8b00101DOI Listing
May 2018

Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein.

Cell Chem Biol 2018 04 27;25(4):357-369.e6. Epub 2018 Jan 27.

Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, Münster, North Rhine-Westphalia 48149, Germany; Bioanalytical Mass Spectrometry, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, Münster, North Rhine-Westphalia 48149, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.12.014DOI Listing
April 2018

Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell-based Compound Discovery and Target Prediction.

Angew Chem Int Ed Engl 2017 10 18;56(42):13021-13025. Epub 2017 Sep 18.

Abteilung für Chemische Biologie, Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn-Straße 11, 44227, Dortmund, Germany.

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http://dx.doi.org/10.1002/anie.201707394DOI Listing
October 2017

Professional translational research: a new hybrid paradigm in early drug discovery.

Future Med Chem 2015 30;7(14):1879-89. Epub 2015 Sep 30.

Lead Discovery Center GmbH, Otto-Hahn-Straße 15, 44227 Dortmund, Germany.

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http://dx.doi.org/10.4155/fmc.15.124DOI Listing
July 2016

A flexible multiwell format for immunofluorescence screening microscopy of small-molecule inhibitors.

Assay Drug Dev Technol 2010 Oct 28;8(5):571-80. Epub 2010 Jul 28.

Department of Vertebrate Genomics, Max-Planck Institute for Molecular Genetics, Berlin, Germany.

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http://dx.doi.org/10.1089/adt.2009.0260DOI Listing
October 2010

Protein kinase inhibitors of the quinazoline class exert anti-cytomegaloviral activity in vitro and in vivo.

Antiviral Res 2008 Jul 22;79(1):49-61. Epub 2008 Feb 22.

Center for Infectious Diseases and Microbiology Translational Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.1016/j.antiviral.2008.01.154DOI Listing
July 2008

An RNA molecule that specifically inhibits G-protein-coupled receptor kinase 2 in vitro.

RNA 2008 Mar 29;14(3):524-34. Epub 2008 Jan 29.

Life and Medical Sciences Bonn, Program Unit Chemical Biology, c/o Kekulé-Institute for Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

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http://dx.doi.org/10.1261/rna.821908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248252PMC
March 2008

Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysin.

Mol Biol Cell 2007 Sep 11;18(9):3591-600. Epub 2007 Jul 11.

Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.1091/mbc.e07-01-0035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1951756PMC
September 2007

Second-generation kinase inhibitors.

Expert Opin Ther Targets 2005 Oct;9(5):975-93

GPC Biotech AG, Max-Lebsche-Platz 32, D-81377 Munich, Germany.

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http://dx.doi.org/10.1517/14728222.9.5.975 DOI Listing
October 2005

Drug discovery in the kinase inhibitory field using the Nested Chemical Library technology.

Assay Drug Dev Technol 2005 Oct;3(5):543-51

Peptide Biochemistry Research Group of Hungarian Academy of Sciences in Department of Medicinal Chemistry and Pathobiochemistry and Rational Drug Design Laboratory Cooperative Research Center, Semmelweis University, Budapest, Hungary.

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http://dx.doi.org/10.1089/adt.2005.3.543DOI Listing
October 2005

Synthesis of selective SRPK-1 inhibitors: novel tricyclic quinoxaline derivatives.

Bioorg Med Chem Lett 2005 Jul;15(13):3241-6

Peptide Biochemistry Res. Group of Hung. Acad. Sci. and Cooperative Research Centre, Semmelweis University, Rippl-Rónai u. 37., Budapest 1062, Hungary.

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http://dx.doi.org/10.1016/j.bmcl.2005.04.064DOI Listing
July 2005

Advances in anti-viral therapeutics.

Authors:
Bert M Klebl

Expert Opin Investig Drugs 2005 Mar;14(3):343-8

Axxima Pharmaceuticals AG, Max-Lebsche-Platz 32, D-81377 Munich, Germany.

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http://dx.doi.org/10.1517/13543784.14.3.343DOI Listing
March 2005

Cellular targets of gefitinib.

Cancer Res 2005 Jan;65(2):379-82

Axxima Pharmaceuticals AG, Munich, Germany.

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January 2005

The tyrosine kinase inhibitor STI571 induces cellular clearance of PrPSc in prion-infected cells.

J Biol Chem 2004 Oct 9;279(40):41918-27. Epub 2004 Jul 9.

Institute of Virology, Prion Research Group, Technical University of Munich, Biedersteiner Strasse 29, D-80802 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M405652200DOI Listing
October 2004

Chemical kinomics - a target gene family approach in chemical biology.

Authors:
Bert M Klebl

Drug Discov Today Technol 2004 Sep;1(1):25-34

Axxima Pharmaceuticals AG, Max-Lebsche-Platz 32, 81377, Munich, Germany. Electronic

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http://dx.doi.org/10.1016/j.ddtec.2004.08.013DOI Listing
September 2004

Screening assay for the identification of deoxyhypusine synthase inhibitors.

J Biomol Screen 2004 Aug;9(5):434-8

Department of Assay Development and Screening, Axxima Pharmaceuticals AG, Max-Lebsche-Platz 32, D-81377 München, Germany.

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http://dx.doi.org/10.1177/1087057104264031DOI Listing
August 2004

Protein kinase G from pathogenic mycobacteria promotes survival within macrophages.

Science 2004 Jun 20;304(5678):1800-4. Epub 2004 May 20.

Biozentrum, University of Basel, Klingelbergstr. 50/70, CH-4056 Basel, Switzerland.

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http://dx.doi.org/10.1126/science.1099384DOI Listing
June 2004

Evaluation of kinase inhibitor selectivity by chemical proteomics.

Assay Drug Dev Technol 2004 Apr;2(2):215-24

Axxima Pharmaceuticals AG, München, Germany.

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http://dx.doi.org/10.1089/154065804323056558DOI Listing
April 2004

Interplay between mycobacteria and host signalling pathways.

Nat Rev Microbiol 2004 Mar;2(3):189-202

Axxima Pharmaceuticals AG, Max-Lebsche-Platz 32, 81377 Munich, Germany.

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http://dx.doi.org/10.1038/nrmicro840DOI Listing
March 2004

Stacking up the armory against viruses.

Authors:
Bert M Klebl

Drug Discov Today 2004 Feb;9(4):162-4

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http://dx.doi.org/10.1016/S1359-6446(03)02970-2DOI Listing
February 2004

Generation of conditional lethal Candida albicans mutants by inducible deletion of essential genes.

Mol Microbiol 2002 Oct;46(1):269-80

Institüt für Molekulare Infektionsbiologie, Universität Würzburg, Röntgenring 11, D-97070 Würzburg, Germany.

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http://dx.doi.org/10.1046/j.1365-2958.2002.03167.xDOI Listing
October 2002