Publications by authors named "Bernoussi Zakia"

18 Publications

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Concurrent Angiomyolipoma and Clear Cell Renal Cell Carcinoma in the Same Kidney: A Rare Finding in a Patient without Tuberous Sclerosis.

Case Rep Urol 2021 1;2021:6663369. Epub 2021 Sep 1.

Department of Pathology, Ibn Sina University Hospital Center, Rabat, Morocco.

Synchronous renal cell carcinomas (RCC) and angiomyolipomas (AML) occurring in the same kidney are rare. Cases in the setting of tuberous sclerosis (TS) have been reported in the literature. However, the association of these tumors in the same kidney without TS is even more rare. We report here a case of a clear cell renal cell carcinoma (CCRCC) associated with an AML in the same kidney in a 42 years old female lacking the TS diagnostic criteria. The patient underwent a radical nephrectomy. Six months after surgery, the patient is healthy without signs of tumor recurrence or distant metastasis.
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http://dx.doi.org/10.1155/2021/6663369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426085PMC
September 2021

Kaposi sarcoma of the adrenal gland: A report of two cases with a review of the literature.

J Cancer Res Ther 2021 Apr-Jun;17(2):606-608

Department of Pathology, Ibn Sina Teaching Hospital, Rabat, Morocco.

Kaposi sarcoma (KS) is a low-grade vascular neoplasm commonly involving mucocutaneous sites, while adrenal gland involvement is exceptional. The anaplastic variant is a rare entity characterized by marked cellular pleomorphism, increased mitosis, worse prognosis, and an increased metastatic potential. The diagnosis remains on histology and immunohistochemistry. We describe two cases of primary adrenal KS to report on this exceptional presentation of KS: the first case is a 67-year-old female with anaplastic KS wit fatal outcome. The second case is a 56-year-old male who presented a classic KS of the adrenal gland. Until now, no standard efficient treatment regimens have been clearly identified. There is a need for a further understanding of anaplastic KS's biology, and collecting a sizable patient cohort remains essential to review treatment outcome.
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http://dx.doi.org/10.4103/jcrt.JCRT_670_20DOI Listing
June 2021

Leiomyosarcoma of the Renal Vein Mimicking a Primitive Renal Cell Carcinoma: Case Report of an Unusual Presentation.

Case Rep Pathol 2021 12;2021:6637533. Epub 2021 May 12.

Department of Pathology, Ibn Sina University Hospital Center, Rabat, Morocco.

Primary leiomyosarcomas (LMS) of vascular origin are rare tumors, and more than half of the cases arise in the inferior vena cava (IVC). Primary LMS of the renal vein are extremely rare tumors with only a few cases reported in the literature. Their diagnosis is made only by pathological features. Histologically, they are made of atypical spindle-shaped cells arranged in long intersecting fascicles. Tumor cells stain positive for myogenic markers in immunohistochemistry. Standard treatment consists of radical nephrectomy followed by chemotherapy and/or radiotherapy. Because of insufficient histological data and follow-up, the prognosis factors are not well identified. Overall prognosis of renal vein LMS is poor. We report here an exceptional case of a huge LMS of the right renal vein mimicking a primitive renal cell carcinoma, occurring in a 56-year-old male patient.
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http://dx.doi.org/10.1155/2021/6637533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133846PMC
May 2021

Primary Hodgkin lymphoma of the ulnar nerve: the first case report with review of the literature.

J Surg Case Rep 2021 May 20;2021(5):rjab185. Epub 2021 May 20.

Department of Pathology, Ibn Sina Teaching Hospital, Abderrahim Bouabid Avenue, Rabat 12000, Morocco.

Hodgkin lymphoma is a lymphoid malignancy characterized by minority population of neoplastic cells (Reed-Sternberg cells and its variants) within a reactive inflammatory background. It encompasses two entities: classical HL (∼95% of cases) and nodular lymphocyte predominant HL (∼5% of cases). Primary lymphoma of peripheral nerves (PLPN) represent a very rare condition, since only 19 cases have been reported in the English literature to date, all of which are of a non-HL phenotype. A 20-year-old female presented an intramural mass of the ulnar nerve. Histological analysis revealed a Classical Hodgkin lymphoma. Further investigations failed to reveal nodal or extranodal involvement. PLPN is a very rare entity. There is a need for further understanding of this unusual lymphoma presentation.
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http://dx.doi.org/10.1093/jscr/rjab185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136864PMC
May 2021

Retroperitoneal leiomyoma of gynecologic type: a case report and review of the litterature.

J Surg Case Rep 2020 Dec 24;2020(12):rjaa489. Epub 2020 Dec 24.

Department of Pathology, Ibn Sina Teaching Hospital, Rabat, Morocco.

Retroperitoneal leiomyomas are rare benign tumors with smooth muscle differentiation, with only ~1001 cases reported in the English literature to date. Because of its scarcity and non-specific presentation, the preoperative diagnosis might be challenging. On histology, these neoplasms share the same macroscopic, morphological and phenotypic features with uterine leiomyoma; thus, they are referred to as leiomyoma of gynecologic type. Herein, we describe a case of a voluminous retroperitoneal leiomyoma in a 51-year-old woman with a history of total hysterectomy to raise awareness about this condition, as its differential diagnosis might be challenging.
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http://dx.doi.org/10.1093/jscr/rjaa489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758995PMC
December 2020

Adrenocortical sarcomatoid carcinoma: a case report and review of the literature.

J Surg Case Rep 2020 Jul 16;2020(7):rjaa211. Epub 2020 Jul 16.

Department of Pathology, Ibn Sina Teaching Hospital, Rabat, Morocco.

Adrenal sarcomatoid carcinoma (ASC) is a very rare aggressive variant of adrenocortical carcinoma showing carcinomatous and sarcomatous differentiation. It is a poorly differentiated carcinoma with poor prognosis. The diagnosis requires careful histological and immunohistochemical investigation. We describe a new case of ASC to raise awareness on this extremely rare entity. A 27-year-old woman presented with a right flank pain. Imaging revealed a tissular mass of the right adrenal gland without metastases. After adrenalectomy, histology revealed sheets of epithelioid cells that stained for synaptophysin and Melan-A; and spindled cells staining for S-100. We have reported the clinical and histopathological features of ACS's case; as it is an extremely rare cancer with a challenging diagnosis. There is a need for a further understanding of ASC's biology to improve it poor prognosis.
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http://dx.doi.org/10.1093/jscr/rjaa211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371253PMC
July 2020

Calcifying Fibrous Tumor of the Mesentery: A Case Report and a Review of the Literature.

Clin Pathol 2020 Jan-Dec;13:2632010X20930689. Epub 2020 Jun 23.

Department of Pathology, Ibn Sina Teaching Hospital, Rabat, Morocco.

Background: Calcifying fibrous tumor (CFT) is a rare entity, with a distinctive histological presentation, initially reported as childhood fibrous tumor with psammoma bodies. It is a benign hypocellular fibrous neoplasm calcifications and lymphoplasmacytic infiltrate. The CFTs may involve many sites, including gastrointestinal tract, pleura, abdominal cavity, and neck. The diagnosis might be challenging due to histological overlaps with other mesenchymal tumors. The prognosis is good. We describe herein the case of a 53-year-old woman with an incidentally diagnosed CFT of the mesentery.

Case Presentation: A 53-year-old woman presented to the surgery department with a 2-year history of an anterior abdominal hernia. A computed tomographic scan of the abdomen failed to demonstrate any evidence of a mesenteric nodule. The patient underwent surgical treatment. Careful exploration during the excision of herniated sac revealed a solitary nodule of the mesentery. Local excision was performed. On gross, it was a well-demarcated nodule. Microscopically, the tumor consisted of an abundant paucicellular hyalinized collagen with calcifications; associated to a sparse mononuclear inflammatory infiltrate.

Conclusions: Calcifying fibrous tumor is a benign lesion. The diagnosis is based on histology, because clinical and radiological features are nonspecific. Awareness of this entity is crucial to distinguish it from other mesenchymal tumors especially in the gastrointestinal tract.
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http://dx.doi.org/10.1177/2632010X20930689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313334PMC
June 2020

[Recurrence of pseudomyxoma peritonei with liver and splenic metastases: about a case and literature review].

Pan Afr Med J 2018 25;30:225. Epub 2018 Jul 25.

Laboratoire d'Anatomie Pathologique, Centre Hospitalier Universitaire Avicenne, Rabat, Maroc.

Pseudomyxoma peritonei (PMP) is a clinicopathologic syndrome characterized by mucinous ascites and pools of mucin resulting in neoplastic mucinous epithelium in the peritoneal cavity. PMP is uncommon and it is characterized by clinical and unusual pathologic manifestations posing diagnostic and therapeutic problems. Involvement of abdominal viscera and lymph node metastases are rare and sporadic cases have been reported in the literature. We here report the case of a 56-year old patient who had undergone two operations for PMP of appendicular origin presenting with progressive abdominal pain five years after his last treatment. Scanner objectified a recurrence of peritoneal pseudo-myxoma with liver and splenic intraparenchymatous lesions. Anatomopathological examination showed intrasplenic and hepatic recurrence of low-grade peritoneal pseudo-myxoma confirming the metastases.
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http://dx.doi.org/10.11604/pamj.2018.30.225.15484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295300PMC
January 2019

[A splenic tendonitis ?]

Presse Med 2019 01 12;48(1 Pt 1):91-94. Epub 2018 Dec 12.

Hôpital Ibn Sina, service d'anatomie pathologique, Rabat, Maroc.

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http://dx.doi.org/10.1016/j.lpm.2018.11.013DOI Listing
January 2019

[Pneumoblastoma in adults: a new case report and literature review].

Pan Afr Med J 2017 2;28:198. Epub 2017 Nov 2.

Labaoratoire d'Anatomie Pathologique/Hopital Militaire Mohamed V, Rabat, Maroc.

Pulmonary blastoma is a rare tumor which has been mainly reported in children. It accounts for 0.25-0.5% of all pulmonary tumors, with a very serious prognosis. Histologically, it is a tumor composed of two components: an epithelial component and a mesenchymal component. Clinically, it usually manifests as chest pain, cough, hemoptysis and dyspnea, but it is asymptomatic in approximately 40% of cases. We report the case of a 25 year old woman, with no previous medical history, who complained of dyspnoea, cough and left basithoracic pain. Radiological evaluation showed large basithoracic mass in the left lung. A biopsy was performed which only showed necrotic material. The surgical specimen was largely necrotic. The viable tissue was examined with the miroscope which showed biphasic pattern composed of malignant epithelial tissue associated with malignant mesenchymal tissue, typical of biphasic pneumoblastoma. The patient underwent chemotherapy and radiation therapy. Follow-up examination showed a recurrence, thus the patient underwent second line chemotherapy.
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http://dx.doi.org/10.11604/pamj.2017.28.198.13907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878848PMC
May 2018

Acute intestinal obstruction revealing synchronous gastrointestinal stromal tumors in a small bowel diverticulum and mucinous adenocarcinoma of the colon: a case report.

Pan Afr Med J 2015 2;21:172. Epub 2015 Jul 2.

Department of Pathology, Ibn Sina University Hospital, Rabat, Morocco.

Unlabelled: Gastrointestinalstromal tumors are rare neoplasms and represent 0,1% to 3% of all gastrointestinal cancers. They are the most frequent mesenchymal neoplasms of the gastrointestinal tract with a malignant potential and unpredictable behavior. The synchronous association with other primary gastrointestinal carcinoma has been rarely reported in the literature with increasing number in the last ten years. The associated Gastrointestinalstromal tumor is usually discovered incidentally during surgery for carcinoma. The limited number of these cases cannot confirm the existence of a common factor in tumorigenesis of these different tumors and other studies are needed to clarify the possible association. We report the first case in the literature of synchronous primary Gastrointestinalstromal tumors developed in small bowel diverticulum and mucinous adenocarcinoma of the colon.

Key Words: Synchronous, Gastrointestinalstromal tumors, Adenocarcinoma, Colon.
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http://dx.doi.org/10.11604/pamj.2015.21.172.2828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802801PMC
December 2016

Malignant peripheral nerve sheath tumor of the small bowel: an unusual presentation with fatal outcome.

Case Rep Oncol Med 2013 28;2013:423867. Epub 2013 Aug 28.

Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco.

Malignant peripheral nerve sheath tumor of the small bowel is an extremely rare disease. Histologic distinction from other types of soft tissue sarcoma especially fibrosarcoma and leiomyosarcoma requires electron microscopy. Complete surgery remains the only curative treatment. However, late diagnosis makes curative surgery more difficult. The contribution of chemotherapy to incomplete surgery has been proved without controlled studies. We report a case of this type of lesion discovered following a small bowel perforation.
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http://dx.doi.org/10.1155/2013/423867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771463PMC
September 2013

[Frantz tumor: 2 new cases].

Pan Afr Med J 2013 4;14. Epub 2013 Jan 4.

Service Central D'anatomie Pathologique et Cytologie, CHU Ibn Sina, Rabat, Morocco.

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http://dx.doi.org/10.11604/pamj.2013.14.7.1412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597855PMC
September 2013

Primary retroperitoneal mucinous cystadenoma with borderline malignancy in a male patient: a case report.

Cases J 2009 Nov 27;2:9098. Epub 2009 Nov 27.

Pathology Departement. Ibn Sina Hopital. Mohamed V University, Rabat, Morocco.

Introduction: Primary retroperitoneal mucinous cystadenoma is a rare tumor prevailing specifically in female gender. Its histogenesis is still unclear and its diagnosis is mainly based on morphological characteristics.

Case Presentation: the subject is a 44 years old man presenting an abdominal pain on the right side, with a palpable mass which appeared four months ago. Abdominal ultrasound (echography) revealed a retroperitoneal cystic process, which was successfully resected through laparotomy. Histopathological examination concluded to a mucinous cystadenoma with borderline malignancy foci. After a year of follow-up, no relapse was noticed in this patient.

Conclusion: Retroperitoneal mucinous cystadenoma is a rare tumor that should be considered in front of a retroperitoneal cystic process. Several hypotheses may explain the histogenesis of this pathological process. The interest in publishing this case report on primary retroperitoneal mucinous cystadenoma in a male patient lies in the rarity of occurrence of this syndrom in males as compared to females.
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http://dx.doi.org/10.1186/1757-1626-2-9098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803895PMC
November 2009

[An unusual parathyroid tumor].

Ann Pathol 2005 Dec;25(6):555-6

Laboratoire Central d'Anatomie Pathologique, Avicenne, CHU Rabat, Maroc.

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http://dx.doi.org/10.1016/s0242-6498(05)86167-xDOI Listing
December 2005

[Pseudo-tumoral colic metaplasia of the urinary bladder].

Prog Urol 2002 Apr;12(2):325-8

Clinique urologique A, Hôpital Avicenne, Rabat, Maroc.

Colic metaplasia of the urinary bladder is a rare disease, secondary to a chronic irritative factor. In its minor form, it has the same clinical features as simple cystitis, but its major pseudoneoplastic form may be mistaken for bladder tumor. The diagnosis is essentially histological. Treatment is based on eradication of the irritative factor and of the resection of pseudoneoplastic form. Surgery is performed in the case of complications of this disease. The clinical course is unclear, requiring long-term surveillance. We report one case of colic-type glandular metaplasia of the urinary bladder in a 50 years-old patient. The clinical symptomatology was dominated by hematuria and pollakuria. A bladder neoplasm was highly suspected in ultrasound and endoscopic findings. The patient underwent a transurethral resection of the bladder tumor. Histological examination of of resection shavings revealed a colic-type glandular metaplasia.
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April 2002
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