Publications by authors named "Bernhard Ryffel"

100Publications

Natterin an aerolysin-like fish toxin drives IL-1β-dependent neutrophilic inflammation mediated by caspase-1 and caspase-11 activated by the inflammasome sensor NLRP6.

Int Immunopharmacol 2020 Dec 27;91:107287. Epub 2020 Dec 27.

Immunoregulation Unit of the Laboratory of Applied Toxinology (CETICs/FAPESP), Butantan Institute, Vital Brazil Avenue, 1500. Butantan, 05503-009 São Paulo. Brazil.

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December 2020

Silica-related diseases in the modern world: A role for self-DNA sensing in lung inflammatory diseases.

Allergy 2020 11;75(11):3009-3010

Experimental and Molecular Immunology and Neurogenetics, UMR7355, CNRS and University of Orleans, Lausanne, France.

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November 2020

Oxidative Stress in Ozone-Induced Chronic Lung Inflammation and Emphysema: A Facet of Chronic Obstructive Pulmonary Disease.

Front Immunol 2020 2;11:1957. Epub 2020 Sep 2.

Section of Airways Disease, National Heart and Lung Institute, Imperial College London, London, United Kingdom.

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September 2020

Hippocampal interleukin-33 mediates neuroinflammation-induced cognitive impairments.

J Neuroinflammation 2020 Sep 11;17(1):268. Epub 2020 Sep 11.

UMR7355, Experimental and Molecular Immunology and Neurogenetics, CNRS and University of Orléans, 3B rue de la Ferollerie, 45071, Orléans, France.

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September 2020

Regulation of IL (Interleukin)-33 Production in Endothelial Cells via Kinase Activation and Fas/CD95 Upregulation.

Arterioscler Thromb Vasc Biol 2020 11 10;40(11):2619-2631. Epub 2020 Sep 10.

CNRS UMR 9017, Inserm U1019, CIIL-Center for Infection and Immunity of Lille (C.D., P.M., V.L., C.G.), CHU Lille, Institut Pasteur de Lille, University Lille, France.

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November 2020

Molecular basis of carrageenan-induced cytokines production in macrophages.

Cell Commun Signal 2020 09 7;18(1):141. Epub 2020 Sep 7.

Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Center for Research in Inflammatory Diseases (CRID)Av. Bandeirantes 3900, 14049-900, Ribeirão Preto, SP, Brazil.

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September 2020

Regulatory T cells: A potential weapon to combat COVID-19?

MedComm (Beijing) 2020 Aug 6. Epub 2020 Aug 6.

Department of Internal Medicine Ohio State University College of Medicine and Wexner Medical Center, Medical Center Columbus Ohio.

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August 2020

Innate type 1 immune response, but not IL-17 cells control tuberculosis infection.

Biomed J 2020 Jul 3. Epub 2020 Jul 3.

Molecular and Experimental Immunology and Neurogenetics, UMR 7355, INEM, CNRS-University of Orleans, Orleans, France. Electronic address:

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July 2020

Complete ablation of tumor necrosis factor decreases the production of IgA, IgG, and IgM in experimental central nervous system tuberculosis.

Iran J Basic Med Sci 2020 May;23(5):680-690

Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.

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May 2020

Effects of Nintedanib in an Animal Model of Liver Fibrosis.

Biomed Res Int 2020 31;2020:3867198. Epub 2020 Mar 31.

Molecular Immunology, INEM, UMR7355, CNRS and University Orléans, Orléans 45071, France.

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March 2020

Secoeudesma sesquiterpenes lactone A alleviates inflammation and offers adjuvant protection in severe infection of carbapenem-resistant Klebsiella pneumoniae.

J Ethnopharmacol 2020 Apr 22;252:112605. Epub 2020 Jan 22.

Department of Immunology and Microbiology, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address:

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April 2020

Blockade of the NLRP3 inflammasome improves metabolic health and lifespan in obese mice.

Geroscience 2020 04 23;42(2):715-725. Epub 2020 Jan 23.

Cátedra de Reproducción y Genética Humana del Instituto para el Estudio de la Biología de la Reproducción Humana (INEBIR), Universidad Europea del Atlántico (UNEATLANTICO)-Fundación Universitaria Iberoamericana (FUNIBER), Santander, Spain.

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April 2020

Acute Respiratory Barrier Disruption by Ozone Exposure in Mice.

Front Immunol 2019 13;10:2169. Epub 2019 Sep 13.

Laboratory of Experimental and Molecular Immunology and Neurogenetics (INEM), UMR 7355 CNRS-University of Orleans, Orléans, France.

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October 2020

ILC2s and Basophils Team Up to Orchestrate IL-33-Induced Atopic Dermatitis.

J Invest Dermatol 2019 10;139(10):2077-2079

Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil.

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October 2019

Self-DNA Sensing in Lung Inflammatory Diseases.

Trends Immunol 2019 08 28;40(8):719-734. Epub 2019 Jun 28.

CNRS, UMR7355, Orleans, France; Experimental and Molecular Immunology and Neurogenetics, University of Orleans, Orleans, France. Electronic address:

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August 2019

Myeloid cell TNFR1 signaling dependent liver injury and inflammation upon BCG infection.

Sci Rep 2019 03 28;9(1):5297. Epub 2019 Mar 28.

Department of Pathology and Immunology, Centre Medical Universitaire (CMU), Faculty of Medicine, University of Geneva, Geneva, 1211, Switzerland.

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March 2019

A New Bifidobacteria Expression SysTem (BEST) to Produce and Deliver Interleukin-10 in .

Front Microbiol 2018 21;9:3075. Epub 2018 Dec 21.

EA 4065, Ecosystème Intestinal, Probiotiques, Antibiotiques, Faculté de Pharmacie de Paris, DHU Risques et Grossesse, Université Paris Descartes, Paris, France.

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December 2018

PD-1 Is Involved in the Dysregulation of Type 2 Innate Lymphoid Cells in a Murine Model of Obesity.

Cell Rep 2018 11;25(8):2053-2060.e4

Laboratory of Immunobiology, Department of Molecular Biology, Université Libre de Bruxelles, 6041 Gosselies, Belgium.

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November 2018

Oxidized hemoglobin forms contribute to NLRP3 inflammasome-driven IL-1β production upon intravascular hemolysis.

Biochim Biophys Acta Mol Basis Dis 2019 02 30;1865(2):464-475. Epub 2018 Oct 30.

Research Centre for Molecular Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. Electronic address:

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February 2019

Exclusive expression of transmembrane TNF aggravates acute glomerulonephritis despite reduced leukocyte infiltration and inflammation.

Kidney Int 2019 01 30;95(1):75-93. Epub 2018 Oct 30.

Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, Germany. Electronic address:

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January 2019

Gut Microbiota-Stimulated Innate Lymphoid Cells Support β-Defensin 14 Expression in Pancreatic Endocrine Cells, Preventing Autoimmune Diabetes.

Cell Metab 2018 10 12;28(4):557-572.e6. Epub 2018 Jul 12.

Institut Necker-Enfants Malades (INEM), Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Sorbonne Universités, Paris, France. Electronic address:

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October 2018

Functional and morphological differences of the lung upon acute and chronic ozone exposure in mice.

Sci Rep 2018 Jul 13;8(1):10611. Epub 2018 Jul 13.

Laboratory of experimental and molecular immunology and neurogenetics (INEM), UMR 7355 CNRS-University of Orleans, University of Orleans, F-45071, Orleans-Cedex2, France.

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July 2018

Transmembrane TNF and Partially TNFR1 Regulate TNFR2 Expression and Control Inflammation in Mycobacterial-Induced Pleurisy.

Int J Mol Sci 2018 07 4;19(7). Epub 2018 Jul 4.

Department of Pathology and Immunology, Centre Medical Universitaire (CMU), Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.

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July 2018

Interleukin-1α Mediates Ozone-Induced Myeloid Differentiation Factor-88-Dependent Epithelial Tissue Injury and Inflammation.

Front Immunol 2018 7;9:916. Epub 2018 May 7.

Laboratory of Experimental and Molecular Immunology and Neurogenetics (INEM), UMR 7355 CNRS-University of Orleans, Orleans, France.

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June 2019

Induction of NLRP3 Inflammasome Activation by Heme in Human Endothelial Cells.

Oxid Med Cell Longev 2018 20;2018:4310816. Epub 2018 Mar 20.

Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen 4032, Hungary.

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October 2018

MyD88 as a therapeutic target for inflammatory lung diseases.

Expert Opin Ther Targets 2018 05 20;22(5):401-408. Epub 2018 Apr 20.

b Laboratory of experimental and molecular immunology and neurogenetics (INEM) , UMR 7355 CNRS-University of Orleans , Orleans , France.

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May 2018

Gain of function mutation and inflammasome driven diseases in human and mouse models.

J Autoimmun 2018 07 30;91:13-22. Epub 2018 Mar 30.

Laboratory of Experimental and Molecular Immunology and Neurogenetics (INEM), UMR 7355 CNRS-University of Orleans, Orléans, France; IDM, University of Cape Town, South Africa.

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July 2018

Humoral Responses Elicited by Adenovirus Displaying Epitopes Are Induced Independently of the Infection Process and Shaped by the Toll-Like Receptor/MyD88 Pathway.

Front Immunol 2018 5;9:124. Epub 2018 Feb 5.

Vectorologie et thérapeutiques anticancéreuses, UMR 8203, CNRS, Univ. Paris-Sud, Gustave Roussy, Université Paris-Saclay, Villejuif, France.

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March 2019

Ozone exposure induces respiratory barrier biphasic injury and inflammation controlled by IL-33.

J Allergy Clin Immunol 2018 09 10;142(3):942-958. Epub 2018 Jan 10.

Laboratory of Experimental and Molecular Immunology and Neurogenetics (INEM), UMR 7355 CNRS-University of Orleans, Orleans, France; ArtImmune SAS, Orleans, France. Electronic address:

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September 2018

NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction.

Oncotarget 2017 Nov 8;8(59):99740-99756. Epub 2017 Sep 8.

Institute of Nutrition and Food Technology "José Mataix Verdú", Department of Physiology, Biomedical Research Center, University of Granada, Granada, Spain.

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November 2017

AMP-Activated Protein Kinase Regulation of the NLRP3 Inflammasome during Aging.

Trends Endocrinol Metab 2018 01 14;29(1):8-17. Epub 2017 Nov 14.

Laboratory of Experimental and Molecular Immunology and Neurogenetics (INEM), UMR 7355 CNRS-University of Orleans, Orléans, France and IDM, University of Cape Town, Cape Town, South Africa.

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January 2018

Osteoblast Hypoxia-Inducible Factor-1α Pathway Activation Restrains Osteoclastogenesis the Interleukin-33-MicroRNA-34a-Notch1 Pathway.

Front Immunol 2017 16;8:1312. Epub 2017 Oct 16.

Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese-Western Medicine, Shanghai Institute of Traumatology and Orthopedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

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October 2017

Diagnostic accuracy of a selected signature gene set that discriminates active pulmonary tuberculosis and other pulmonary diseases.

J Infect 2017 12 20;75(6):499-510. Epub 2017 Sep 20.

Program of Immunology, Affiliated Guangzhou Women and Children's Medical Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, PR China; Institute of Tuberculosis Control, Key Laboratory of Tropical Diseases Control, Ministry of Education, Sun Yat-sen University, Guangzhou, PR China; Guangzhou Chest Hospital, Guangzhou, PR China; Department of Infectious Diseases, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, PR China. Electronic address:

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December 2017

IL-36γ Induced by the TLR3-SLUG-VDR Axis Promotes Wound Healing via REG3A.

J Invest Dermatol 2017 12 31;137(12):2620-2629. Epub 2017 Jul 31.

Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, People's Republic of China. Electronic address:

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December 2017

The Emerging Roles of STING in Bacterial Infections.

Trends Microbiol 2017 11 15;25(11):906-918. Epub 2017 Jun 15.

CNRS, UMR7355, Orleans, France; Experimental and Molecular Immunology and Neurogenetics, University of Orleans, France. Electronic address:

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November 2017

microRNA cluster 106a~363 is involved in T helper 17 cell differentiation.

Immunology 2017 11 28;152(3):402-413. Epub 2017 Jul 28.

Comprehensive Pneumology Centre, Helmholtz Zentrum München, University Hospital of the Ludwig Maximilians University, Member of the German Centre for Lung Research, Munich, Germany.

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November 2017

Experimental atopic dermatitis depends on IL-33R signaling via MyD88 in dendritic cells.

Cell Death Dis 2017 04 6;8(4):e2735. Epub 2017 Apr 6.

Experimental and Molecular Immunology and Neurogenetics (INEM), UMR 7355 CNRS and University of Orleans, F-45071 Orleans-Cedex 2, France.

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April 2017

Myeloid and T Cell-Derived TNF Protects against Central Nervous System Tuberculosis.

Front Immunol 2017 23;8:180. Epub 2017 Feb 23.

Division of Immunology, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; South African Medical Research Council, Cape Town, South Africa; National Health Laboratory Service, Johannesburg, South Africa.

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February 2017

Interleukin-33 drives hepatic fibrosis through activation of hepatic stellate cells.

Cell Mol Immunol 2018 Apr 13;15(4):388-398. Epub 2017 Feb 13.

Molecular Immunology and Embryology, UMR 7355, CNRS, University of Orleans, Orléans, France.

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April 2018

Neutrophils releasing IL-17A into NETs are essential to plasma cell differentiation in inflamed tissue dependent on IL-1R.

Autoimmunity 2017 Mar 23;50(2):86-101. Epub 2016 Dec 23.

a Immunoregulation Unit of the Special Laboratory of Applied Toxinology (CEPID/FAPESP), Butantan Institute , São Paulo , Brazil.

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March 2017

Persistent p55TNFR expression impairs T cell responses during chronic tuberculosis and promotes reactivation.

Sci Rep 2016 12 20;6:39499. Epub 2016 Dec 20.

Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.

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December 2016

Glufosinate aerogenic exposure induces glutamate and IL-1 receptor dependent lung inflammation.

Clin Sci (Lond) 2016 11 22;130(21):1939-54. Epub 2016 Aug 22.

UMR7355, CNRS, 45 071 Orleans cedex 2, France INEM, Experimental and Molecular Immunology and Neurogenetics, University of Orleans, 3b rue de la Férollerie, 45071 Orleans Cedex 2, France

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November 2016

Tumor Necrosis Factor and Its Receptors Are Crucial to Control Mycobacterium bovis Bacillus Calmette-Guerin Pleural Infection in a Murine Model.

Am J Pathol 2016 09 25;186(9):2364-77. Epub 2016 Jul 25.

Department of Pathology and Immunology, Centre Medical Universitaire, University of Geneva Medical School, Geneva, Switzerland. Electronic address:

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September 2016

Role of interleukin-1 receptor 1/MyD88 signalling in the development and progression of pulmonary hypertension.

Eur Respir J 2016 08 13;48(2):470-83. Epub 2016 Jul 13.

INSERM U955 and Département de Physiologie, Hôpital Henri Mondor, AP-HP, DHU-ATVB, F-94010, Université Paris-Est Créteil (UPEC), Créteil, France

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August 2016

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance.

Cancer Cell 2016 07;30(1):147-160

Gustave Roussy Cancer Campus, 94800 Villejuif, France; INSERM, U1138, 75006 Paris, France; Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France; Université Paris Descartes/Paris V, Sorbonne Paris Cité, 75006 Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, 94800 Villejuif, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, 75015 Paris, France; Department of Women's and Children's Health, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden; INSERM U1138, Centre de Recherche des Cordeliers, 75006 Paris, France. Electronic address:

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July 2016

Inflammasome, IL-1 and inflammation in ozone-induced lung injury.

Am J Clin Exp Immunol 2016 23;5(1):33-40. Epub 2016 Mar 23.

CNRS, UMR7355, Experimental and Molecular Immunology and Neurogenetics45071 Orleans, France; IDM, University of Cape TownRSA.

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May 2016

Identification of Immune Effectors Essential to the Control of Primary and Secondary Intranasal Infection with Brucella melitensis in Mice.

J Immunol 2016 05 1;196(9):3780-93. Epub 2016 Apr 1.

Microorganisms Biology Research Unit (URBM), Laboratory of Immunology and Microbiology, Namur Research Institute for Life Sciences, University of Namur, 5000 Namur, Belgium; Laboratoire de Parasitologie, Faculté de Médecine, Université Libre de Bruxelles, 1070 Bruxelles, Belgium

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May 2016

In Situ Characterization of Splenic Brucella melitensis Reservoir Cells during the Chronic Phase of Infection in Susceptible Mice.

PLoS One 2015 16;10(9):e0137835. Epub 2015 Sep 16.

Unité de Recherche en Biologie des Microorganismes, Laboratoire d'Immunologie et de Microbiologie, Université de Namur, Namur, Belgium; Laboratoire de Parasitologie, Université Libre de Bruxelles, Campus Erasme, Bruxelles, Belgique.

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May 2016