Publications by authors named "Bernhard Ryffel"

100Publications

Natterin an aerolysin-like fish toxin drives IL-1β-dependent neutrophilic inflammation mediated by caspase-1 and caspase-11 activated by the inflammasome sensor NLRP6.

Authors:
Carla Lima Maria Alice Pimentel Falcao Aline Ingrid Andrade-Barros Ana Carolina Seni-Silva Lidiane Zito Grund Eniko Balogh Katia Conceiçao Valerie F Queniaux Bernhard Ryffel Monica Lopes-Ferreira

Int Immunopharmacol 2020 Dec 27;91:107287. Epub 2020 Dec 27.

Immunoregulation Unit of the Laboratory of Applied Toxinology (CETICs/FAPESP), Butantan Institute, Vital Brazil Avenue, 1500. Butantan, 05503-009 São Paulo. Brazil.

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December 2020

Ketogenic diet and ketone bodies enhance the anticancer effects of PD1 blockade.

Authors:
Gladys Ferrere Maryam Tidjani Alou Peng Liu Anne-Gaëlle Goubet Marine Fidelle Oliver Kepp Sylvère Durand Valerio Iebba Aurélie Fluckiger Romain Daillère Cassandra Thelemaque Claudia Grajeda-Iglesias Carolina Alves Costa Silva Fanny Aprahamian Deborah Lefevre Liwei Zhao Bernhard Ryffel Emeline Colomba Monica Arnedos Damien Drubay Conrad Rauber Didier Raoult Francesco Asnicar Tim Spector Nicola Segata Lisa Derosa Guido Kroemer Laurence Zitvogel

JCI Insight 2020 Dec 15. Epub 2020 Dec 15.

Institut Gustave Roussy, INSERM U1015, Villejuif, France.

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December 2020

Corrigendum: Blockade of IL-33R/ST2 Signaling Attenuates Ileitis Depending on IL-22 Expression.

Authors:
Bernhard Ryffel Feng Huang Pauline Robinet Corine Panek Isabelle Couillin François Erard Julie Piotet Marc Le Bert Claire Mackowiak Marbel Torres Arias Isabelle Dimier-Poisson Song Guo Zheng

Front Immunol 2020 28;11:592865. Epub 2020 Oct 28.

Department of Internal Medicine, Ohio State College of Medicine, Columbus, OH, United States.

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October 2020

Silica-related diseases in the modern world: A role for self-DNA sensing in lung inflammatory diseases.

Authors:
Dieudonnée Togbe Sulayman Benmerzoug Muazzam Jacobs Bernhard Ryffel Valerie F J Quesniaux

Allergy 2020 11;75(11):3009-3010

Experimental and Molecular Immunology and Neurogenetics, UMR7355, CNRS and University of Orleans, Lausanne, France.

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November 2020

Oxidative Stress in Ozone-Induced Chronic Lung Inflammation and Emphysema: A Facet of Chronic Obstructive Pulmonary Disease.

Authors:
Coen H Wiegman Feng Li Bernhard Ryffel Dieudonnée Togbe Kian Fan Chung

Front Immunol 2020 2;11:1957. Epub 2020 Sep 2.

Section of Airways Disease, National Heart and Lung Institute, Imperial College London, London, United Kingdom.

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September 2020

Hippocampal interleukin-33 mediates neuroinflammation-induced cognitive impairments.

Authors:
Flora Reverchon Vidian de Concini Vanessa Larrigaldie Sulayman Benmerzoug Sylvain Briault Dieudonnée Togbé Bernhard Ryffel Valérie F J Quesniaux Arnaud Menuet

J Neuroinflammation 2020 Sep 11;17(1):268. Epub 2020 Sep 11.

UMR7355, Experimental and Molecular Immunology and Neurogenetics, CNRS and University of Orléans, 3B rue de la Ferollerie, 45071, Orléans, France.

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September 2020

Regulation of IL (Interleukin)-33 Production in Endothelial Cells via Kinase Activation and Fas/CD95 Upregulation.

Authors:
Catherine Duez Barbara Gross Philippe Marquillies Valérie Ledroit Bernhard Ryffel Corine Glineur

Arterioscler Thromb Vasc Biol 2020 11 10;40(11):2619-2631. Epub 2020 Sep 10.

CNRS UMR 9017, Inserm U1019, CIIL-Center for Infection and Immunity of Lille (C.D., P.M., V.L., C.G.), CHU Lille, Institut Pasteur de Lille, University Lille, France.

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November 2020

Molecular basis of carrageenan-induced cytokines production in macrophages.

Authors:
Alexandre H Lopes Rangel L Silva Miriam D Fonseca Francisco I Gomes Alexandre G Maganin Lucas S Ribeiro Lucas Maciel Mauriz Marques Fernando Q Cunha Jose C Alves-Filho Dario S Zamboni Norberto P Lopes Bernardo S Franklin Aurélie Gombault Fernando Silva Ramalho Valerie F J Quesniaux Isabelle Couillin Bernhard Ryffel Thiago M Cunha

Cell Commun Signal 2020 09 7;18(1):141. Epub 2020 Sep 7.

Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Center for Research in Inflammatory Diseases (CRID)Av. Bandeirantes 3900, 14049-900, Ribeirão Preto, SP, Brazil.

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September 2020

B-Cell Activating Factor Secreted by Neutrophils Is a Critical Player in Lung Inflammation to Cigarette Smoke Exposure.

Authors:
Mégane Nascimento Sarah Huot-Marchand Aurélie Gombault Corinne Panek Manon Bourinet Manoussa Fanny Florence Savigny Pascal Schneider Marc Le Bert Bernhard Ryffel Nicolas Riteau Valérie F J Quesniaux Isabelle Couillin

Front Immunol 2020 29;11:1622. Epub 2020 Jul 29.

University of Orleans and CNRS, INEM-UMR7355, Orléans, France.

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July 2020

Regulatory T cells: A potential weapon to combat COVID-19?

Authors:
Yu Liu Guangying Qi Joseph A Bellanti René Moser Bernhard Ryffel Song Guo Zheng

MedComm (Beijing) 2020 Aug 6. Epub 2020 Aug 6.

Department of Internal Medicine Ohio State University College of Medicine and Wexner Medical Center, Medical Center Columbus Ohio.

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August 2020

Innate type 1 immune response, but not IL-17 cells control tuberculosis infection.

Authors:
Noria Segueni Muazzam Jacobs Bernhard Ryffel

Biomed J 2020 Jul 3. Epub 2020 Jul 3.

Molecular and Experimental Immunology and Neurogenetics, UMR 7355, INEM, CNRS-University of Orleans, Orleans, France. Electronic address:

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July 2020

MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression.

Authors:
João Paulo M Luiz Juliana E Toller-Kawahisa Paula R Viacava Daniele C Nascimento Priscilla T Pereira André L Saraiva Douglas S Prado Marc LeBert Emanuele Giurisato Cathy Tournier Thiago M Cunha Fernando Q Cunha Valerie Quesniaux Bernhard Ryffel José C Alves-Filho

J Leukoc Biol 2020 Oct 3;108(4):1215-1223. Epub 2020 Aug 3.

Center for Research in Inflammatory Diseases and Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

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October 2020

Complete ablation of tumor necrosis factor decreases the production of IgA, IgG, and IgM in experimental central nervous system tuberculosis.

Authors:
Ngiambudulu M Francisco Nasiema Allie Boipelo Sebesho Bernhard Ryffel Muazzam Jacobs

Iran J Basic Med Sci 2020 May;23(5):680-690

Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.

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May 2020

The commensal skin microbiota triggers type I IFN-dependent innate repair responses in injured skin.

Authors:
Jeremy Di Domizio Cyrine Belkhodja Pauline Chenuet Anissa Fries Timothy Murray Paula Marcos Mondéjar Olivier Demaria Curdin Conrad Bernhard Homey Sabine Werner Daniel E Speiser Bernhard Ryffel Michel Gilliet

Nat Immunol 2020 09 13;21(9):1034-1045. Epub 2020 Jul 13.

Department of Dermatology, CHUV University Hospital, University of Lausanne, Lausanne, Switzerland.

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September 2020

Effects of Nintedanib in an Animal Model of Liver Fibrosis.

Authors:
Lutz Wollin Dieudonnée Togbe Bernhard Ryffel

Biomed Res Int 2020 31;2020:3867198. Epub 2020 Mar 31.

Molecular Immunology, INEM, UMR7355, CNRS and University Orléans, Orléans 45071, France.

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March 2020

Lactobacillus reuteri 5454 and Bifidobacterium animalis ssp. lactis 5764 improve colitis while differentially impacting dendritic cells maturation and antimicrobial responses.

Authors:
Jiří Hrdý Jeanne Alard Aurelie Couturier-Maillard Olivier Boulard Denise Boutillier Myriam Delacre Carmen Lapadatescu Annabelle Cesaro Philippe Blanc Bruno Pot Bernhard Ryffel Mathias Chamaillard Corinne Grangette

Sci Rep 2020 03 24;10(1):5345. Epub 2020 Mar 24.

Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000, Lille, France.

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March 2020

Ozone-Induced Aryl Hydrocarbon Receptor Activation Controls Lung Inflammation via Interleukin-22 Modulation.

Authors:
Chloé Michaudel Florent Bataille Isabelle Maillet Louis Fauconnier Cyril Colas Harry Sokol Marjolène Straube Aurélie Couturier-Maillard Laure Dumoutier Jacques van Snick Valérie F Quesniaux Dieudonnée Togbe Bernhard Ryffel

Front Immunol 2020 25;11:144. Epub 2020 Feb 25.

Laboratory of Experimental and Molecular Immunology and Neurogenetics, UMR 7355 CNRS-University of Orleans, Orléans, France.

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February 2020

Secoeudesma sesquiterpenes lactone A alleviates inflammation and offers adjuvant protection in severe infection of carbapenem-resistant Klebsiella pneumoniae.

Authors:
Xinru Jiang Yijian Chen Dan Liu Ting Shi Xiaodong Cheng Weigang He Yinhong Li Bernhard Ryffel Song Guo Zheng Yuejuan Zheng

J Ethnopharmacol 2020 Apr 22;252:112605. Epub 2020 Jan 22.

Department of Immunology and Microbiology, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address:

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April 2020

Blockade of the NLRP3 inflammasome improves metabolic health and lifespan in obese mice.

Authors:
Diego Cañadas-Lozano Fabiola Marín-Aguilar Beatriz Castejón-Vega Bernhard Ryffel José M Navarro-Pando Jesús Ruiz-Cabello Elísabet Alcocer-Gómez Pedro Bullón Mario D Cordero

Geroscience 2020 04 23;42(2):715-725. Epub 2020 Jan 23.

Cátedra de Reproducción y Genética Humana del Instituto para el Estudio de la Biología de la Reproducción Humana (INEBIR), Universidad Europea del Atlántico (UNEATLANTICO)-Fundación Universitaria Iberoamericana (FUNIBER), Santander, Spain.

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April 2020

The alternative cap-binding complex is required for antiviral defense in vivo.

Authors:
Anna Gebhardt Valter Bergant Daniel Schnepf Markus Moser Arno Meiler Dieudonnée Togbe Claire Mackowiak Line S Reinert Søren R Paludan Bernhard Ryffel Alexey Stukalov Peter Staeheli Andreas Pichlmair

PLoS Pathog 2019 12 19;15(12):e1008155. Epub 2019 Dec 19.

Institute of Virology, Technical University of Munich, School of Medicine, Munich, Germany.

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December 2019

CD3 Macrophages Deliver Proinflammatory Cytokines by a CD3- and Transmembrane TNF-Dependent Pathway and Are Increased at the BCG-Infection Site.

Authors:
Adriana Rodriguez-Cruz Dominique Vesin Lucero Ramon-Luing Joaquin Zuñiga Valérie F J Quesniaux Bernhard Ryffel Ricardo Lascurain Irene Garcia Leslie Chávez-Galán

Front Immunol 2019 7;10:2550. Epub 2019 Nov 7.

Laboratory of Integrative Immunology, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Mexico City, Mexico.

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September 2020

Muc5b-deficient mice develop early histological lung abnormalities.

Authors:
Hélène Valque Valérie Gouyer Catherine Duez Christophe Leboeuf Philippe Marquillies Marc Le Bert Ségolène Plet Bernhard Ryffel Anne Janin Frédéric Gottrand Jean-Luc Desseyn

Biol Open 2019 Nov 7;8(11). Epub 2019 Nov 7.

LIRIC UMR 995; Univ. Lille; Inserm; CHU Lille, F-59045 Lille, France

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November 2019

NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice.

Authors:
Fabiola Marín-Aguilar Ana V Lechuga-Vieco Elísabet Alcocer-Gómez Beatriz Castejón-Vega Javier Lucas Carlos Garrido Alejandro Peralta-Garcia Antonio J Pérez-Pulido Alfonso Varela-López José L Quiles Bernhard Ryffel Ignacio Flores Pedro Bullón Jesús Ruiz-Cabello Mario D Cordero

Aging Cell 2020 01 18;19(1):e13050. Epub 2019 Oct 18.

Institute of Nutrition and Food Technology "José Mataix Verdú", Department of Physiology, Biomedical Research Center, University of Granada, Granada, Spain.

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January 2020

Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice.

Authors:
Mégane Nascimento Aurélie Gombault Norinne Lacerda-Queiroz Corinne Panek Florence Savigny Malak Sbeity Manon Bourinet Marc Le Bert Nicolas Riteau Bernhard Ryffel Valérie F J Quesniaux Isabelle Couillin

Sci Rep 2019 10 16;9(1):14848. Epub 2019 Oct 16.

University of Orleans and CNRS, INEM-UMR7355, Orleans, France.

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October 2019

Acute Respiratory Barrier Disruption by Ozone Exposure in Mice.

Authors:
Milena Sokolowska Valerie F J Quesniaux Cezmi A Akdis Kian Fan Chung Bernhard Ryffel Dieudonnée Togbe

Front Immunol 2019 13;10:2169. Epub 2019 Sep 13.

Laboratory of Experimental and Molecular Immunology and Neurogenetics (INEM), UMR 7355 CNRS-University of Orleans, Orléans, France.

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October 2020

NLRP3 Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPARα Activity.

Authors:
Fabiola Marín-Aguilar Beatriz Castejón-Vega Elísabet Alcocer-Gómez Debora Lendines-Cordero Matthew A Cooper Patricia de la Cruz Eloísa Andújar-Pulido Mónica Pérez-Alegre Jordi Muntané Antonio J Pérez-Pulido Bernhard Ryffel Avril A B Robertson Jesús Ruiz-Cabello Pedro Bullón Mario D Cordero

J Gerontol A Biol Sci Med Sci 2020 Jul;75(8):1457-1464

Institute of Nutrition and Food Technology "José Mataix Verdú", Department of Physiology, Biomedical Research Center, University of Granada, Spain.

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July 2020

ILC2s and Basophils Team Up to Orchestrate IL-33-Induced Atopic Dermatitis.

Authors:
Bernhard Ryffel José Carlos Alves-Filho

J Invest Dermatol 2019 10;139(10):2077-2079

Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil.

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October 2019

Microbial metabolites control the thymic development of mucosal-associated invariant T cells.

Authors:
François Legoux Déborah Bellet Celine Daviaud Yara El Morr Aurelie Darbois Kristina Niort Emanuele Procopio Marion Salou Jules Gilet Bernhard Ryffel Aurélie Balvay Anne Foussier Manal Sarkis Ahmed El Marjou Frederic Schmidt Sylvie Rabot Olivier Lantz

Science 2019 10 29;366(6464):494-499. Epub 2019 Aug 29.

INSERM U932, PSL University, Institut Curie, Paris 75005, France.

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October 2019

Self-DNA Sensing in Lung Inflammatory Diseases.

Authors:
Sulayman Benmerzoug Bernhard Ryffel Dieudonnée Togbe Valerie F J Quesniaux

Trends Immunol 2019 08 28;40(8):719-734. Epub 2019 Jun 28.

CNRS, UMR7355, Orleans, France; Experimental and Molecular Immunology and Neurogenetics, University of Orleans, Orleans, France. Electronic address:

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August 2019

Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring.

Authors:
Matthew G Darby Alisha Chetty Dunja Mrjden Marion Rolot Katherine Smith Claire Mackowiak Delphine Sedda Donald Nyangahu Heather Jaspan Kai-Michael Toellner Ari Waisman Valerie Quesniaux Bernhard Ryffel Adam F Cunningham Benjamin G Dewals Frank Brombacher William G C Horsnell

Sci Adv 2019 05 29;5(5):eaav3058. Epub 2019 May 29.

Institute of Infectious Disease and Molecular Medicine and Division of Immunology, University of Cape Town, Cape Town 7925, South Africa.

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May 2019

Sterile Lung Inflammation Induced by Silica Exacerbates Mycobacterium tuberculosis Infection via STING-Dependent Type 2 Immunity.

Authors:
Sulayman Benmerzoug Badreddine Bounab Stéphanie Rose David Gosset Franck Biet Thierry Cochard Aurore Xavier Nathalie Rouxel Louis Fauconnier William G C Horsnell Bernhard Ryffel Dieudonnee Togbe Valerie F J Quesniaux

Cell Rep 2019 05;27(9):2649-2664.e5

CNRS, UMR7355, Orléans 45071, France; Experimental and Molecular Immunology and Neurogenetics, University of Orléans, Orléans 45071, France. Electronic address:

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May 2019

Blockade of IL-33R/ST2 Signaling Attenuates Ileitis Depending on IL-22 Expression.

Authors:
Bernhard Ryffel Feng Huang Pauline Robinet Corine Panek Isabelle Couillin François Erard Julie Piotet Marc Le Bert Claire Mackowiak Marbel Torres Arias Isabelle Dimier-Poisson Song Guo Zheng

Front Immunol 2019 18;10:702. Epub 2019 Apr 18.

Department of Internal Medicine, Ohio State College of Medicine, Columbus, OH, United States.

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July 2020

Myeloid cell TNFR1 signaling dependent liver injury and inflammation upon BCG infection.

Authors:
Leslie Chavez-Galan Dominique Vesin Guillaume Blaser Husnu Uysal Sulayman Benmerzoug Stéphanie Rose Bernhard Ryffel Valérie F J Quesniaux Irene Garcia

Sci Rep 2019 03 28;9(1):5297. Epub 2019 Mar 28.

Department of Pathology and Immunology, Centre Medical Universitaire (CMU), Faculty of Medicine, University of Geneva, Geneva, 1211, Switzerland.

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March 2019

A New Bifidobacteria Expression SysTem (BEST) to Produce and Deliver Interleukin-10 in .

Authors:
Aurélie Mauras Florian Chain Aurélie Faucheux Pauline Ruffié Sophie Gontier Bernhard Ryffel Marie-José Butel Philippe Langella Luis G Bermúdez-Humarán Anne-Judith Waligora-Dupriet

Front Microbiol 2018 21;9:3075. Epub 2018 Dec 21.

EA 4065, Ecosystème Intestinal, Probiotiques, Antibiotiques, Faculté de Pharmacie de Paris, DHU Risques et Grossesse, Université Paris Descartes, Paris, France.

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December 2018

Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens.

Authors:
Sylvain Normand Nadine Waldschmitt Andreas Neerincx Ruben Julio Martinez-Torres Camille Chauvin Aurélie Couturier-Maillard Olivier Boulard Laetitia Cobret Fawaz Awad Ludovic Huot Andre Ribeiro-Ribeiro Katja Lautz Richard Ruez Myriam Delacre Clovis Bondu Martin Guilliams Charlotte Scott Anthony Segal Serge Amselem David Hot Sonia Karabina Erwin Bohn Bernhard Ryffel Lionel F Poulin Thomas A Kufer Mathias Chamaillard

Nat Commun 2018 12 17;9(1):5338. Epub 2018 Dec 17.

University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000, Lille, France.

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December 2018

STING-dependent sensing of self-DNA drives silica-induced lung inflammation.

Authors:
Sulayman Benmerzoug Stéphanie Rose Badreddine Bounab David Gosset Laure Duneau Pauline Chenuet Lucile Mollet Marc Le Bert Christopher Lambers Silvana Geleff Michael Roth Louis Fauconnier Delphine Sedda Clarisse Carvalho Olivier Perche David Laurenceau Bernhard Ryffel Lionel Apetoh Ahmet Kiziltunc Hakan Uslu Fadime Sultan Albez Metin Akgun Dieudonnée Togbe Valerie F J Quesniaux

Nat Commun 2018 12 6;9(1):5226. Epub 2018 Dec 6.

CNRS, UMR7355, Orleans, 45071, France.

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December 2018

Interleukin-17/interleukin-17 receptor axis elicits intestinal neutrophil migration, restrains gut dysbiosis and lipopolysaccharide translocation in high-fat diet-induced metabolic syndrome model.

Authors:
Malena M Pérez Larissa M S Martins Murilo S Dias Camila A Pereira Jefferson A Leite Enrico C S Gonçalves Paula Z de Almeida Emanuelle N de Freitas Rita C Tostes Simone G Ramos Marcel R de Zoete Bernhard Ryffel João S Silva Daniela Carlos

Immunology 2019 04 27;156(4):339-355. Epub 2018 Dec 27.

Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

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April 2019

PD-1 Is Involved in the Dysregulation of Type 2 Innate Lymphoid Cells in a Murine Model of Obesity.

Authors:
Guillaume Oldenhove Elodie Boucquey Anaelle Taquin Valérie Acolty Lynn Bonetti Bernhard Ryffel Marc Le Bert Kevin Englebert Louis Boon Muriel Moser

Cell Rep 2018 11;25(8):2053-2060.e4

Laboratory of Immunobiology, Department of Molecular Biology, Université Libre de Bruxelles, 6041 Gosselies, Belgium.

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November 2018

Oxidized hemoglobin forms contribute to NLRP3 inflammasome-driven IL-1β production upon intravascular hemolysis.

Authors:
Benard Bogonko Nyakundi Andrea Tóth Enikő Balogh Béla Nagy Judit Erdei Bernhard Ryffel György Paragh Mario D Cordero Viktória Jeney

Biochim Biophys Acta Mol Basis Dis 2019 02 30;1865(2):464-475. Epub 2018 Oct 30.

Research Centre for Molecular Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. Electronic address:

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February 2019

Exclusive expression of transmembrane TNF aggravates acute glomerulonephritis despite reduced leukocyte infiltration and inflammation.

Authors:
Martin B Müller John M Hoppe Andrei Bideak Moritz Lux Maja T Lindenmeyer Susanna Müller Nuru Eltrich Bernhard Ryffel Volker Vielhauer

Kidney Int 2019 01 30;95(1):75-93. Epub 2018 Oct 30.

Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, Germany. Electronic address:

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January 2019

The regenerating family member 3 β instigates IL-17A-mediated neutrophil recruitment downstream of NOD1/2 signalling for controlling colonisation resistance independently of microbiota community structure.

Authors:
Nadine Waldschmitt Sho Kitamoto Thomas Secher Vassiliki Zacharioudaki Olivier Boulard Emilie Floquet Myriam Delacre Bruno Lamas Hang-Phuong Pham Adrien Six Mathias L Richard Jean-Charles Dagorn Gérard Eberl Philippe Langella Jean-Marc Chatel Bernhard Ryffel Juan Lucio Iovanna Lionel F Poulin Harry Sokol Nobuhiko Kamada Mathias Chamaillard

Gut 2019 07 2;68(7):1190-1199. Epub 2018 Oct 2.

CIIL - Centre d'Infection et d'Immunité de Lille, Université de Lille, CNRS, Inserm, CHRU Lille, Institut Pasteur de Lille, U1019 - UMR 8204, F-59000, Lille, France.

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July 2019

Interleukin-33 contributes to disease severity in Dengue virus infection in mice.

Authors:
Rafael E Marques Anne-Gaëlle Besnard Isabelle Maillet Caio T Fagundes Danielle G Souza Bernhard Ryffel Mauro M Teixeira Foo Y Liew Rodrigo Guabiraba

Immunology 2018 12 10;155(4):477-490. Epub 2018 Sep 10.

INRA, ISP, UMR1282, Université de Tours, Tours, France.

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December 2018

Liver Immune Cells Release Type 1 Interferon Due to DNA Sensing and Amplify Liver Injury from Acetaminophen Overdose.

Authors:
Alan Moreira de Araujo Maísa Mota Antunes Matheus Silvério Mattos Ariane Barros Diniz Débora Moreira Alvarenga Brenda Naemi Nakagaki Érika de Carvalho Viviane Aparecida Souza Lacerda Raquel Carvalho-Gontijo Jorge Goulart Kassiana Mafra Maria Alice Freitas-Lopes Hortência Maciel de Castro Oliveira Camila Miranda Dutra Bruna Araújo David Aristóbolo Mendes Silva Valerie Quesniaux Bernhard Ryffel Sergio Costa Oliveira Glen N Barber Daniel Santos Mansur Thiago Mattar Cunha Rafael Machado Rezende André Gustavo Oliveira Gustavo Batista Menezes

Cells 2018 Jul 27;7(8). Epub 2018 Jul 27.

Center for Gastrointestinal Biology, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av Antonio Carlos, 6627-Belo Horizonte, Minas Gerais 31270-901, Brazil.

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July 2018

The probiotic strain Escherichia coli Nissle 1917 prevents papain-induced respiratory barrier injury and severe allergic inflammation in mice.

Authors:
Thomas Secher Isabelle Maillet Claire Mackowiak Jessica Le Bérichel Amandine Philippeau Corinne Panek Michèle Boury Eric Oswald Abdelhadi Saoudi Francois Erard Marc Le Bert Valérie Quesniaux Aurélie Couturier-Maillard Bernhard Ryffel

Sci Rep 2018 07 26;8(1):11245. Epub 2018 Jul 26.

CNRS, UMR7355, Experimental and Molecular Immunology and Neurogenetics, Orleans, France.

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July 2018

Gut Microbiota-Stimulated Innate Lymphoid Cells Support β-Defensin 14 Expression in Pancreatic Endocrine Cells, Preventing Autoimmune Diabetes.

Authors:
Michela Miani Julie Le Naour Emmanuelle Waeckel-Enée Subash Chand Verma Marjolène Straube Patrick Emond Bernhard Ryffel Peter van Endert Harry Sokol Julien Diana

Cell Metab 2018 10 12;28(4):557-572.e6. Epub 2018 Jul 12.

Institut Necker-Enfants Malades (INEM), Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Sorbonne Universités, Paris, France. Electronic address:

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October 2018

Functional and morphological differences of the lung upon acute and chronic ozone exposure in mice.

Authors:
Chloé Michaudel Louis Fauconnier Yvon Julé Bernhard Ryffel

Sci Rep 2018 Jul 13;8(1):10611. Epub 2018 Jul 13.

Laboratory of experimental and molecular immunology and neurogenetics (INEM), UMR 7355 CNRS-University of Orleans, University of Orleans, F-45071, Orleans-Cedex2, France.

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July 2018

The IL-33 Receptor ST2 Regulates Pulmonary Inflammation and Fibrosis to Bleomycin.

Authors:
Manoussa Fanny Mégane Nascimento Ludivine Baron Corinne Schricke Isabelle Maillet Myriam Akbal Nicolas Riteau Marc Le Bert Valérie Quesniaux Bernhard Ryffel Aurélie Gombault Sandra Même William Même Isabelle Couillin

Front Immunol 2018 25;9:1476. Epub 2018 Jun 25.

University of Orleans and CNRS, UMR7355, Orleans, France.

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June 2018

Transmembrane TNF and Partially TNFR1 Regulate TNFR2 Expression and Control Inflammation in Mycobacterial-Induced Pleurisy.

Authors:
Husnu Uysal Leslie Chavez-Galan Dominique Vesin Guillaume Blaser Mahdia Benkhoucha Bernhard Ryffel Valérie F J Quesniaux Irene Garcia

Int J Mol Sci 2018 07 4;19(7). Epub 2018 Jul 4.

Department of Pathology and Immunology, Centre Medical Universitaire (CMU), Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.

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July 2018

G-quadruplex DNA targeting alters class-switch recombination in B cells and attenuates allergic inflammation.

Authors:
Zeinab Dalloul Pauline Chenuet Iman Dalloul François Boyer Jean-Claude Aldigier Brice Laffleur Yolla El Makhour Bernhard Ryffel Valerie F J Quesniaux Dieudonnée Togbé Jean-Louis Mergny Jeanne Cook-Moreau Michel Cogné

J Allergy Clin Immunol 2018 10 20;142(4):1352-1355. Epub 2018 Jun 20.

Limoges University, Limoges, France. Electronic address:

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October 2018

Succinate receptor deficiency attenuates arthritis by reducing dendritic cell traffic and expansion of T17 cells in the lymph nodes.

Authors:
André L Saraiva Flávio P Veras Raphael S Peres Jhimmy Talbot Kalil A de Lima João P Luiz José M Carballido Thiago M Cunha Fernando Q Cunha Bernhard Ryffel Jose C Alves-Filho

FASEB J 2018 Jun 12:fj201800285. Epub 2018 Jun 12.

Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil.

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June 2018

PD-1/PD-L1 pathway: an adaptive immune resistance mechanism to immunogenic chemotherapy in colorectal cancer.

Authors:
Magalie Dosset Thaiz Rivera Vargas Anaïs Lagrange Romain Boidot Frédérique Végran Aurélie Roussey Fanny Chalmin Lucile Dondaine Catherine Paul Elodie Lauret Marie-Joseph François Martin Bernhard Ryffel Christophe Borg Olivier Adotévi François Ghiringhelli Lionel Apetoh

Oncoimmunology 2018;7(6):e1433981. Epub 2018 Mar 15.

INSERM, U1231, Dijon, France.

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March 2018

GM-CSF targeted immunomodulation affects host response to M. tuberculosis infection.

Authors:
Sulayman Benmerzoug Fabio Vitarelli Marinho Stéphanie Rose Claire Mackowiak David Gosset Delphine Sedda Emeline Poisson Catherine Uyttenhove Jacques Van Snick Muazzam Jacobs Irene Garcia Bernhard Ryffel Valerie F J Quesniaux

Sci Rep 2018 06 5;8(1):8652. Epub 2018 Jun 5.

CNRS, UMR7355, Orleans, France.

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June 2018

Interleukin-1α Mediates Ozone-Induced Myeloid Differentiation Factor-88-Dependent Epithelial Tissue Injury and Inflammation.

Authors:
Chloé Michaudel Isabelle Maillet Louis Fauconnier Valérie Quesniaux Kian Fan Chung Coen Wiegman Daniel Peter Bernhard Ryffel

Front Immunol 2018 7;9:916. Epub 2018 May 7.

Laboratory of Experimental and Molecular Immunology and Neurogenetics (INEM), UMR 7355 CNRS-University of Orleans, Orleans, France.

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June 2019

The cGAS/STING Pathway Is Important for Dendritic Cell Activation but Is Not Essential to Induce Protective Immunity against Mycobacterium tuberculosis Infection.

Authors:
Fabio V Marinho Sulayman Benmerzoug Stephanie Rose Priscila C Campos João T Marques André Báfica Glen Barber Bernhard Ryffel Sergio C Oliveira Valerie F J Quesniaux

J Innate Immun 2018 23;10(3):239-252. Epub 2018 May 23.

Centre National de la Recherche Scientifique (CNRS), UMR7355, Orleans, France.

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September 2019

Induction of NLRP3 Inflammasome Activation by Heme in Human Endothelial Cells.

Authors:
Judit Erdei Andrea Tóth Enikő Balogh Benard Bogonko Nyakundi Emese Bányai Bernhard Ryffel György Paragh Mario D Cordero Viktória Jeney

Oxid Med Cell Longev 2018 20;2018:4310816. Epub 2018 Mar 20.

Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen 4032, Hungary.

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October 2018

Interleukin-23 promotes intestinal T helper type17 immunity and ameliorates obesity-associated metabolic syndrome in a murine high-fat diet model.

Authors:
Larissa M S Martins Malena M Perez Camila A Pereira Frederico R C Costa Murilo S Dias Rita C Tostes Simone G Ramos Marcel R de Zoete Bernhard Ryffel João S Silva Daniela Carlos

Immunology 2018 May 2. Epub 2018 May 2.

Departments of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.

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May 2018

MyD88 as a therapeutic target for inflammatory lung diseases.

Authors:
Franco Di Padova Valerie F J Quesniaux Bernhard Ryffel

Expert Opin Ther Targets 2018 05 20;22(5):401-408. Epub 2018 Apr 20.

b Laboratory of experimental and molecular immunology and neurogenetics (INEM) , UMR 7355 CNRS-University of Orleans , Orleans , France.

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May 2018

Gain of function mutation and inflammasome driven diseases in human and mouse models.

Authors:
Mario D Cordero Elísabet Alcocer-Gómez Bernhard Ryffel

J Autoimmun 2018 07 30;91:13-22. Epub 2018 Mar 30.

Laboratory of Experimental and Molecular Immunology and Neurogenetics (INEM), UMR 7355 CNRS-University of Orleans, Orléans, France; IDM, University of Cape Town, South Africa.

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July 2018

Humoral Responses Elicited by Adenovirus Displaying Epitopes Are Induced Independently of the Infection Process and Shaped by the Toll-Like Receptor/MyD88 Pathway.

Authors:
Aleksandra Anchim Najat Raddi Lena Zig Patrick Perrieau Ronan Le Goffic Bernhard Ryffel Karim Benihoud

Front Immunol 2018 5;9:124. Epub 2018 Feb 5.

Vectorologie et thérapeutiques anticancéreuses, UMR 8203, CNRS, Univ. Paris-Sud, Gustave Roussy, Université Paris-Saclay, Villejuif, France.

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March 2019

Ozone exposure induces respiratory barrier biphasic injury and inflammation controlled by IL-33.

Authors:
Chloé Michaudel Claire Mackowiak Isabelle Maillet Louis Fauconnier Cezmi A Akdis Milena Sokolowska Anita Dreher Hern-Tze Tina Tan Valérie F Quesniaux Bernhard Ryffel Dieudonnée Togbe

J Allergy Clin Immunol 2018 09 10;142(3):942-958. Epub 2018 Jan 10.

Laboratory of Experimental and Molecular Immunology and Neurogenetics (INEM), UMR 7355 CNRS-University of Orleans, Orleans, France; ArtImmune SAS, Orleans, France. Electronic address:

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September 2018

Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway.

Authors:
Cathleen Holze Chloé Michaudel Claire Mackowiak Darya A Haas Christian Benda Philipp Hubel Friederike L Pennemann Daniel Schnepf Jennifer Wettmarshausen Marianne Braun Daisy W Leung Gaya K Amarasinghe Fabiana Perocchi Peter Staeheli Bernhard Ryffel Andreas Pichlmair

Nat Immunol 2018 02 18;19(2):130-140. Epub 2017 Dec 18.

Innate Immunity Laboratory, Max-Planck Institute of Biochemistry, Martinsried, Munich, Germany.

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February 2018

NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction.

Authors:
Luís E Pavillard Diego Cañadas-Lozano Elísabet Alcocer-Gómez Fabiola Marín-Aguilar Sheila Pereira Avril A B Robertson Jordi Muntané Bernhard Ryffel Matthew A Cooper José L Quiles Pedro Bullón Jesús Ruiz-Cabello Mario D Cordero

Oncotarget 2017 Nov 8;8(59):99740-99756. Epub 2017 Sep 8.

Institute of Nutrition and Food Technology "José Mataix Verdú", Department of Physiology, Biomedical Research Center, University of Granada, Granada, Spain.

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November 2017

Loss of vascular expression of nucleoside triphosphate diphosphohydrolase-1/CD39 in hypertension.

Authors:
Charlotte Roy Julie Tabiasco Antoine Caillon Yves Delneste Jean Merot Julie Favre Anne Laure Guihot Ludovic Martin Daniele C Nascimento Bernhard Ryffel Simon C Robson Jean Sévigny Daniel Henrion Gilles Kauffenstein

Purinergic Signal 2018 03 13;14(1):73-82. Epub 2017 Dec 13.

MITOVASC Institute - UMR CNRS 6015 INSERM U1083 University of Angers, Angers, France.

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March 2018

Tumor Necrosis Factor-Alpha Targeting Can Protect against Arthritis with Low Sensitization to Infection.

Authors:
Nadia Belmellat Luca Semerano Noria Segueni Diane Damotte Patrice Decker Bernhard Ryffel Valérie Quesniaux Marie-Christophe Boissier Eric Assier

Front Immunol 2017 14;8:1533. Epub 2017 Nov 14.

UMR 1125 INSERM, Bobigny, France.

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November 2017

AMP-Activated Protein Kinase Regulation of the NLRP3 Inflammasome during Aging.

Authors:
Mario D Cordero Matthew R Williams Bernhard Ryffel

Trends Endocrinol Metab 2018 01 14;29(1):8-17. Epub 2017 Nov 14.

Laboratory of Experimental and Molecular Immunology and Neurogenetics (INEM), UMR 7355 CNRS-University of Orleans, Orléans, France and IDM, University of Cape Town, Cape Town, South Africa.

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January 2018

Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors.

Authors:
Bertrand Routy Emmanuelle Le Chatelier Lisa Derosa Connie P M Duong Maryam Tidjani Alou Romain Daillère Aurélie Fluckiger Meriem Messaoudene Conrad Rauber Maria P Roberti Marine Fidelle Caroline Flament Vichnou Poirier-Colame Paule Opolon Christophe Klein Kristina Iribarren Laura Mondragón Nicolas Jacquelot Bo Qu Gladys Ferrere Céline Clémenson Laura Mezquita Jordi Remon Masip Charles Naltet Solenn Brosseau Coureche Kaderbhai Corentin Richard Hira Rizvi Florence Levenez Nathalie Galleron Benoit Quinquis Nicolas Pons Bernhard Ryffel Véronique Minard-Colin Patrick Gonin Jean-Charles Soria Eric Deutsch Yohann Loriot François Ghiringhelli Gérard Zalcman François Goldwasser Bernard Escudier Matthew D Hellmann Alexander Eggermont Didier Raoult Laurence Albiges Guido Kroemer Laurence Zitvogel

Science 2018 Jan 2;359(6371):91-97. Epub 2017 Nov 2.

Gustave Roussy Cancer Campus (GRCC), Villejuif, France.

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January 2018

Osteoblast Hypoxia-Inducible Factor-1α Pathway Activation Restrains Osteoclastogenesis the Interleukin-33-MicroRNA-34a-Notch1 Pathway.

Authors:
Hui Kang Kai Yang Lianbo Xiao Lei Guo Changjun Guo Yufei Yan Jin Qi Fei Wang Bernhard Ryffel Changwei Li Lianfu Deng

Front Immunol 2017 16;8:1312. Epub 2017 Oct 16.

Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese-Western Medicine, Shanghai Institute of Traumatology and Orthopedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

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October 2017

IL-33 signalling in liver immune cells enhances drug-induced liver injury and inflammation.

Authors:
Maísa Mota Antunes Alan Moreira Araújo Ariane Barros Diniz Rafaela Vaz Sousa Pereira Débora Moreira Alvarenga Bruna Araújo David Renata Monti Rocha Maria Alice Freitas Lopes Sarah Cozzer Marchesi Brenda Naemi Nakagaki Érika Carvalho Pedro Elias Marques Bernhard Ryffel Valérie Quesniaux Rodrigo Guabiraba Brito José Carlos Alves Filho Denise Carmona Cara Rafael Machado Rezende Gustavo Batista Menezes

Inflamm Res 2018 Jan 14;67(1):77-88. Epub 2017 Oct 14.

Center for Gastrointestinal Biology, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil.

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January 2018

Neutralization of either IL-17A or IL-17F is sufficient to inhibit house dust mite induced allergic asthma in mice.

Authors:
Pauline Chenuet Louis Fauconnier Fahima Madouri Tiffany Marchiol Nathalie Rouxel Aurélie Ledru Pascal Mauny Rachel Lory Catherine Uttenhove Jacques van Snick Yoichiro Iwakura Franco di Padova Valérie Quesniaux Dieudonnée Togbe Bernhard Ryffel

Clin Sci (Lond) 2017 Oct 12;131(20):2533-2548. Epub 2017 Oct 12.

Laboratory of Experimental and Molecular Immunology and Neurogenetics (INEM), UMR 7355 CNRS-University of Orleans, 3B, F-45071 Orleans-Cedex2, France

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October 2017

An Iron-Rich Diet Decreases the Mycobacterial Burden and Correlates With Hepcidin Upregulation, Lower Levels of Proinflammatory Mediators, and Increased T-Cell Recruitment in a Model of Mycobacterium bovis Bacille Calmette-Guerin Infection.

Authors:
Rafiou Agoro Sulayman Benmerzoug Stéphanie Rose Mélanie Bouyer Raffaella Gozzelino Irene Garcia Bernhard Ryffel Valerie F J Quesniaux Catherine Mura

J Infect Dis 2017 10;216(7):907-918

Experimental and Molecular Immunology and Neurogenetics (INEM), Mixed Research Unit UMR7355, National Center for Scientific Research.

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October 2017

Diagnostic accuracy of a selected signature gene set that discriminates active pulmonary tuberculosis and other pulmonary diseases.

Authors:
Ngiambudulu M Francisco Yi-Min Fang Li Ding Siyuan Feng Yiying Yang Minhao Wu Muazzam Jacobs Bernhard Ryffel Xi Huang

J Infect 2017 12 20;75(6):499-510. Epub 2017 Sep 20.

Program of Immunology, Affiliated Guangzhou Women and Children's Medical Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, PR China; Institute of Tuberculosis Control, Key Laboratory of Tropical Diseases Control, Ministry of Education, Sun Yat-sen University, Guangzhou, PR China; Guangzhou Chest Hospital, Guangzhou, PR China; Department of Infectious Diseases, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, PR China. Electronic address:

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December 2017

Transmembrane Tumor Necrosis Factor Controls Myeloid-Derived Suppressor Cell Activity TNF Receptor 2 and Protects from Excessive Inflammation during BCG-Induced Pleurisy.

Authors:
Leslie Chavez-Galan Dominique Vesin Husnu Uysal Guillaume Blaser Mahdia Benkhoucha Bernhard Ryffel Valérie F J Quesniaux Irene Garcia

Front Immunol 2017 25;8:999. Epub 2017 Aug 25.

Department of Pathology and Immunology, Centre Medical Universitaire (CMU), Faculty of Medicine, University of Geneva, Geneva, Switzerland.

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August 2017

Stingray venom activates IL-33 producing cardiomyocytes, but not mast cell, to promote acute neutrophil-mediated injury.

Authors:
Janaina Cardoso Dos Santos Lidiane Zito Grund Carla Simone Seibert Elineide Eugênio Marques Anderson Brito Soares Valerie F Quesniaux Bernhard Ryffel Monica Lopes-Ferreira Carla Lima

Sci Rep 2017 08 11;7(1):7912. Epub 2017 Aug 11.

Immunoregulation Unit of the Special Laboratory of Applied Toxinology(CEPID/FAPESP), Butantan Institute, São Paulo, Brazil.

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August 2017

IL-36γ Induced by the TLR3-SLUG-VDR Axis Promotes Wound Healing via REG3A.

Authors:
Ziwei Jiang Yuanqi Liu Changwei Li Leilei Chang Wang Wang Zhenhua Wang Xiaoguang Gao Bernhard Ryffel Yelin Wu Yuping Lai

J Invest Dermatol 2017 12 31;137(12):2620-2629. Epub 2017 Jul 31.

Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, People's Republic of China. Electronic address:

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December 2017

The Emerging Roles of STING in Bacterial Infections.

Authors:
Fabio V Marinho Sulayman Benmerzoug Sergio C Oliveira Bernhard Ryffel V F J Quesniaux

Trends Microbiol 2017 11 15;25(11):906-918. Epub 2017 Jun 15.

CNRS, UMR7355, Orleans, France; Experimental and Molecular Immunology and Neurogenetics, University of Orleans, France. Electronic address:

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November 2017

microRNA cluster 106a~363 is involved in T helper 17 cell differentiation.

Authors:
Marc Kästle Sabine Bartel Kerstin Geillinger-Kästle Martin Irmler Johannes Beckers Bernhard Ryffel Oliver Eickelberg Susanne Krauss-Etschmann

Immunology 2017 11 28;152(3):402-413. Epub 2017 Jul 28.

Comprehensive Pneumology Centre, Helmholtz Zentrum München, University Hospital of the Ludwig Maximilians University, Member of the German Centre for Lung Research, Munich, Germany.

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November 2017

IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria.

Authors:
Flora Reverchon Stéphane Mortaud Maëliss Sivoyon Isabelle Maillet Anthony Laugeray Jennifer Palomo Céline Montécot Améziane Herzine Sandra Meme William Meme François Erard Bernhard Ryffel Arnaud Menuet Valérie F J Quesniaux

PLoS Pathog 2017 Apr 27;13(4):e1006322. Epub 2017 Apr 27.

CNRS, UMR7355, Orleans, France.

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April 2017

Experimental atopic dermatitis depends on IL-33R signaling via MyD88 in dendritic cells.

Authors:
Changwei Li Isabelle Maillet Claire Mackowiak Camille Viala Franco Di Padova Mei Li Dieudonnée Togbe Valérie Quesniaux Yuping Lai Bernhard Ryffel

Cell Death Dis 2017 04 6;8(4):e2735. Epub 2017 Apr 6.

Experimental and Molecular Immunology and Neurogenetics (INEM), UMR 7355 CNRS and University of Orleans, F-45071 Orleans-Cedex 2, France.

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April 2017

Mitochondrial DNA Activates the NLRP3 Inflammasome and Predisposes to Type 1 Diabetes in Murine Model.

Authors:
Daniela Carlos Frederico R C Costa Camila A Pereira Fernanda A Rocha Juliana N U Yaochite Gabriela G Oliveira Fernando S Carneiro Rita C Tostes Simone G Ramos Dario S Zamboni Niels O S Camara Bernhard Ryffel João S Silva

Front Immunol 2017 27;8:164. Epub 2017 Feb 27.

Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo , Ribeirao Preto , Brazil.

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February 2017

Myeloid and T Cell-Derived TNF Protects against Central Nervous System Tuberculosis.

Authors:
Nai-Jen Hsu Ngiambudulu M Francisco Roanne Keeton Nasiema Allie Valérie F J Quesniaux Bernhard Ryffel Muazzam Jacobs

Front Immunol 2017 23;8:180. Epub 2017 Feb 23.

Division of Immunology, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; South African Medical Research Council, Cape Town, South Africa; National Health Laboratory Service, Johannesburg, South Africa.

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February 2017

Interleukin-33 drives hepatic fibrosis through activation of hepatic stellate cells.

Authors:
Zhongming Tan Qianghui Liu Runqiu Jiang Long Lv Siamak S Shoto Isabelle Maillet Valerie Quesniaux Junwei Tang Wenjie Zhang Beicheng Sun Bernhard Ryffel

Cell Mol Immunol 2018 Apr 13;15(4):388-398. Epub 2017 Feb 13.

Molecular Immunology and Embryology, UMR 7355, CNRS, University of Orleans, Orléans, France.

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April 2018

Neutrophils releasing IL-17A into NETs are essential to plasma cell differentiation in inflamed tissue dependent on IL-1R.

Authors:
Lidiane Zito Grund Ivan Novaski Valerie F Quesniaux Bernhard Ryffel Monica Lopes-Ferreira Carla Lima

Autoimmunity 2017 Mar 23;50(2):86-101. Epub 2016 Dec 23.

a Immunoregulation Unit of the Special Laboratory of Applied Toxinology (CEPID/FAPESP), Butantan Institute , São Paulo , Brazil.

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March 2017

Persistent p55TNFR expression impairs T cell responses during chronic tuberculosis and promotes reactivation.

Authors:
Ivy M Dambuza Roanne Keeton Nai-Jen Hsu Nasiema Allie Valérie F J Quesniaux Bernhard Ryffel Muazzam Jacobs

Sci Rep 2016 12 20;6:39499. Epub 2016 Dec 20.

Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.

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December 2016

Controlled Mycobacterium tuberculosis infection in mice under treatment with anti-IL-17A or IL-17F antibodies, in contrast to TNFα neutralization.

Authors:
Noria Segueni Elaine Tritto Marie-Laure Bourigault Stéphanie Rose François Erard Marc Le Bert Muazzam Jacobs Franco Di Padova Daniel P Stiehl Pierre Moulin Dominique Brees Salah-Dine Chibout Bernhard Ryffel Michael Kammüller Valerie F Quesniaux

Sci Rep 2016 11 17;6:36923. Epub 2016 Nov 17.

CNRS, UMR7355, Orleans, France.

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November 2016

IL-1R1-MyD88 axis elicits papain-induced lung inflammation.

Authors:
Rafiou Agoro Julie Piotet-Morin Jennifer Palomo Chloé Michaudel Solenne Vigne Isabelle Maillet Pauline Chenuet Noëlline Guillou Jessica Le Bérichel Malgorzata Kisielow Per Flodby Zea Borok Edward D Crandall Marc Le Bert Valérie Quesniaux Matthias Muller Franco Di Padova Bernhard Ryffel Cem Gabay Aurélie Couturier-Maillard

Eur J Immunol 2016 11 22;46(11):2531-2541. Epub 2016 Sep 22.

Experimental and Molecular Immunology and Neurogenetics, University of Orleans, CNRS, UMR7355, Orleans, France.

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November 2016

Protein kinase Cθ controls type 2 innate lymphoid cell and T2 responses to house dust mite allergen.

Authors:
Fahima Madouri Pauline Chenuet Chloé Beuraud Louis Fauconnier Tiffany Marchiol Nathalie Rouxel Aurélie Ledru Margaux Gallerand Vincent Lombardi Laurent Mascarell Quentin Marquant Lionel Apetoh François Erard Marc Le Bert Fabrice Trovero Valérie F J Quesniaux Bernhard Ryffel Dieudonnée Togbe

J Allergy Clin Immunol 2017 May 14;139(5):1650-1666. Epub 2016 Oct 14.

Artimmune SAS, Orleans, France. Electronic address:

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May 2017

Glufosinate aerogenic exposure induces glutamate and IL-1 receptor dependent lung inflammation.

Authors:
Isabelle Maillet Olivier Perche Arnaud Pâris Olivier Richard Aurélie Gombault Ameziane Herzine Jacques Pichon Francois Huaux Stéphane Mortaud Bernhard Ryffel Valérie F J Quesniaux Céline Montécot-Dubourg

Clin Sci (Lond) 2016 11 22;130(21):1939-54. Epub 2016 Aug 22.

UMR7355, CNRS, 45 071 Orleans cedex 2, France INEM, Experimental and Molecular Immunology and Neurogenetics, University of Orleans, 3b rue de la Férollerie, 45071 Orleans Cedex 2, France

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November 2016

Tumor Necrosis Factor and Its Receptors Are Crucial to Control Mycobacterium bovis Bacillus Calmette-Guerin Pleural Infection in a Murine Model.

Authors:
Leslie Chavez-Galan Dominique Vesin Noria Segueni Pritha Prasad Raphaële Buser-Llinares Guillaume Blaser Jean-Claude Pache Bernhard Ryffel Valérie F J Quesniaux Irene Garcia

Am J Pathol 2016 09 25;186(9):2364-77. Epub 2016 Jul 25.

Department of Pathology and Immunology, Centre Medical Universitaire, University of Geneva Medical School, Geneva, Switzerland. Electronic address:

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September 2016

Role of interleukin-1 receptor 1/MyD88 signalling in the development and progression of pulmonary hypertension.

Authors:
Aurélien Parpaleix Valérie Amsellem Amal Houssaini Shariq Abid Marielle Breau Elisabeth Marcos Daigo Sawaki Marion Delcroix Rozenn Quarck Aurélie Maillard Isabelle Couillin Bernhard Ryffel Serge Adnot

Eur Respir J 2016 08 13;48(2):470-83. Epub 2016 Jul 13.

INSERM U955 and Département de Physiologie, Hôpital Henri Mondor, AP-HP, DHU-ATVB, F-94010, Université Paris-Est Créteil (UPEC), Créteil, France

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August 2016

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance.

Authors:
Federico Pietrocola Jonathan Pol Erika Vacchelli Shuan Rao David P Enot Elisa E Baracco Sarah Levesque Francesca Castoldi Nicolas Jacquelot Takahiro Yamazaki Laura Senovilla Guillermo Marino Fernando Aranda Sylvère Durand Valentina Sica Alexis Chery Sylvie Lachkar Verena Sigl Norma Bloy Aitziber Buque Simonetta Falzoni Bernhard Ryffel Lionel Apetoh Francesco Di Virgilio Frank Madeo Maria Chiara Maiuri Laurence Zitvogel Beth Levine Josef M Penninger Guido Kroemer

Cancer Cell 2016 07;30(1):147-160

Gustave Roussy Cancer Campus, 94800 Villejuif, France; INSERM, U1138, 75006 Paris, France; Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France; Université Paris Descartes/Paris V, Sorbonne Paris Cité, 75006 Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, 94800 Villejuif, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, 75015 Paris, France; Department of Women's and Children's Health, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden; INSERM U1138, Centre de Recherche des Cordeliers, 75006 Paris, France. Electronic address:

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July 2016

Therapeutic monoclonal antibodies for respiratory diseases: Current challenges and perspectives, March 31 - April 1, 2016, Tours, France.

Authors:
Guillaume Desoubeaux Janice M Reichert Matthew Sleeman Karen L Reckamp Bernhard Ryffel Jörg P Adamczewski Theresa D Sweeney Rita Vanbever Patrice Diot Caroline A Owen Clive Page Stéphanie Lerondel Alain Le Pape Nathalie Heuze-Vourc'h

MAbs 2016 Aug-Sep;8(6):999-1009. Epub 2016 Jun 6.

a Université François-Rabelais , Tours , France.

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December 2017

Inflammasome, IL-1 and inflammation in ozone-induced lung injury.

Authors:
Chloé Michaudel Aurélie Couturier-Maillard Pauline Chenuet Isabelle Maillet Catherine Mura Isabelle Couillin Aurélie Gombault Valérie F Quesniaux François Huaux Bernhard Ryffel

Am J Clin Exp Immunol 2016 23;5(1):33-40. Epub 2016 Mar 23.

CNRS, UMR7355, Experimental and Molecular Immunology and Neurogenetics45071 Orleans, France; IDM, University of Cape TownRSA.

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May 2016

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands.

Authors:
Bruno Lamas Mathias L Richard Valentin Leducq Hang-Phuong Pham Marie-Laure Michel Gregory Da Costa Chantal Bridonneau Sarah Jegou Thomas W Hoffmann Jane M Natividad Loic Brot Soraya Taleb Aurélie Couturier-Maillard Isabelle Nion-Larmurier Fatiha Merabtene Philippe Seksik Anne Bourrier Jacques Cosnes Bernhard Ryffel Laurent Beaugerie Jean-Marie Launay Philippe Langella Ramnik J Xavier Harry Sokol

Nat Med 2016 06 9;22(6):598-605. Epub 2016 May 9.

Sorbonne University-Université Pierre et Marie Curie (UPMC) Paris, France.

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June 2016

Infection-Mediated Priming of Phagocytes Protects against Lethal Secondary Aspergillus fumigatus Challenge.

Authors:
Amélie Savers Orhan Rasid Marianna Parlato Matthias Brock Gregory Jouvion Bernhard Ryffel Jean-Marc Cavaillon Gerard Eberl Oumaïma Ibrahim-Granet

PLoS One 2016 14;11(4):e0153829. Epub 2016 Apr 14.

Institut Pasteur, Unité Cytokines & Inflammation, Paris, France.

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September 2016

Identification of Immune Effectors Essential to the Control of Primary and Secondary Intranasal Infection with Brucella melitensis in Mice.

Authors:
Delphine Hanot Mambres Arnaud Machelart Georges Potemberg Carl De Trez Bernhard Ryffel Jean-Jacques Letesson Eric Muraille

J Immunol 2016 05 1;196(9):3780-93. Epub 2016 Apr 1.

Microorganisms Biology Research Unit (URBM), Laboratory of Immunology and Microbiology, Namur Research Institute for Life Sciences, University of Namur, 5000 Namur, Belgium; Laboratoire de Parasitologie, Faculté de Médecine, Université Libre de Bruxelles, 1070 Bruxelles, Belgium

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May 2016

AhR modulates the IL-22-producing cell proliferation/recruitment in imiquimod-induced psoriasis mouse model.

Authors:
Perrine M Cochez Camille Michiels Emilie Hendrickx Astrid B Van Belle Muriel M Lemaire Nicolas Dauguet Guy Warnier Magali de Heusch Dieudonnée Togbe Bernhard Ryffel Pierre G Coulie Jean-Christophe Renauld Laure Dumoutier

Eur J Immunol 2016 06;46(6):1449-59

Ludwig Institute for Cancer Research, Brussels Branch, Belgium.

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June 2016

Innate myeloid cell TNFR1 mediates first line defence against primary Mycobacterium tuberculosis infection.

Authors:
Noria Segueni Sulayman Benmerzoug Stéphanie Rose Amandine Gauthier Marie-Laure Bourigault Flora Reverchon Amandine Philippeau François Erard Marc Le Bert Hélène Bouscayrol Thierry Wachter Irène Garcia George Kollias Muazzam Jacobs Bernhard Ryffel Valerie F J Quesniaux

Sci Rep 2016 Mar 2;6:22454. Epub 2016 Mar 2.

CNRS, UMR7355, Experimental and Molecular Immunology and Neurogenetics, 45071 Orleans, France.

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March 2016

Corrigendum: The receptor NLRP3 is a transcriptional regulator of TH2 differentiation.

Authors:
Mélanie Bruchard Cédric Rebé Valentin Derangère Dieudonnée Togbé Bernhard Ryffel Romain Boidot Etienne Humblin Arlette Hamman Fanny Chalmin Hélène Berger Angélique Chevriaux Emeric Limagne Lionel Apetoh Frédérique Végran François Ghiringhelli

Nat Immunol 2015 Dec;16(12):1292

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December 2015

Transmembrane TNF-α is sufficient for articular inflammation and hypernociception in a mouse model of gout.

Authors:
Flávio A Amaral Leandro F S Bastos Thiago H C Oliveira Ana C F Dias Vívian L S Oliveira Lívia D Tavares Vivian V Costa Izabela Galvão Frederico M Soriani David E Szymkowski Bernhard Ryffel Danielle G Souza Mauro M Teixeira

Eur J Immunol 2016 Jan 4;46(1):204-11. Epub 2015 Nov 4.

Immunopharmacology Lab, Department of Biochemistry and Immunology, Federal University of Minas, Gerais, Brazil.

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January 2016

In Situ Characterization of Splenic Brucella melitensis Reservoir Cells during the Chronic Phase of Infection in Susceptible Mice.

Authors:
Delphine Hanot Mambres Arnaud Machelart Jean-Marie Vanderwinden Carl De Trez Bernhard Ryffel Jean-Jacques Letesson Eric Muraille

PLoS One 2015 16;10(9):e0137835. Epub 2015 Sep 16.

Unité de Recherche en Biologie des Microorganismes, Laboratoire d'Immunologie et de Microbiologie, Université de Namur, Namur, Belgium; Laboratoire de Parasitologie, Université Libre de Bruxelles, Campus Erasme, Bruxelles, Belgique.

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May 2016