Publications by authors named "Bernhard Landwehrmeyer"

96Publications

Validation Study of a German Cognitive Battery for Huntington's Disease: Relationship Between Cognitive Performance, Functional Decline, and Disease Burden.

Arch Clin Neuropsychol 2021 Jan;36(1):74-86

Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.

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January 2021

PET Molecular Imaging of Phosphodiesterase 10A: An Early Biomarker of Huntington's Disease Progression.

Mov Disord 2020 04 22;35(4):606-615. Epub 2020 Jan 22.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Sweden.

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April 2020

An International Validation of a Clinical Tool to Assess Carers' Quality of Life in Huntington's Disease.

Front Psychol 2019 23;10:1658. Epub 2019 Jul 23.

School of Psychology and Clinical Language Sciences, University of Reading, Reading, United Kingdom.

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July 2019

Targeting Huntingtin Expression in Patients with Huntington's Disease.

N Engl J Med 2019 06 6;380(24):2307-2316. Epub 2019 May 6.

From University College London (UCL) Huntington's Disease Centre, Department of Neurodegenerative Disease, Queen Square Institute of Neurology, UCL, and the U.K. Dementia Research Institute at UCL, London (S.J.T., E.J.W.), the Department of Clinical Neuroscience, Addenbrooke's Hospital, University of Cambridge, Cambridge (R.A.B., N.F.B.), Manchester Centre for Genomic Medicine, St. Mary's Hospital, Manchester University NHS Foundation Trust, and the Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester (D.C.), the University of Edinburgh and the U.K. Dementia Research Institute, Edinburgh (J.P.), the Institute of Clinical Sciences, College of Medical and Dental Sciences, University Hospital Birmingham, Birmingham (H.R.), and the Cardiff University Brain Repair Group, Brain Repair and Intracranial Neurotherapeutics Unit, Neuroscience and Mental Health Research Institute and School of Biosciences, Cardiff (A.R.) - all in the United Kingdom; the Centre for Huntington's Disease, Department of Medical Genetics, and the Division of Neurology, Department of Medicine, University of British Columbia, and the Centre for Molecular Medicine and Therapeutics, B.C. Children's Hospital, Vancouver, Canada (B.R.L.); the Department of Neurology, Ulm University, Huntington's Disease Centre, Ulm (G.B.L.), the Department of Neurology, Huntington Center North Rhine-Westphalia, Ruhr University Bochum, St. Josef-Hospital, Bochum (C.S.), and the Department of Neuropsychiatry, Charité-Universitätsmedizin Berlin, Deutsches Zentrum für Neurodegenerative Erkrankungen, Berlin (J.P.) - all in Germany; Ionis Pharmaceuticals, Carlsbad, CA (H.B.K., E.E.S., D.A.N., T.B., E.P., A.V.S., C.F.B., R.M.L.); and F. Hoffmann-La Roche, Basel, Switzerland (C.C., I.G., S.A.S.).

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June 2019

Serum neurofilament light chain in behavioral variant frontotemporal dementia.

Neurology 2018 10 12;91(15):e1390-e1401. Epub 2018 Sep 12.

From the Department of Neurology (P.S., S.A.-S., E.S., I.U., C.A.F.v.A., J. Kassubek, B.L., P.O., A.C.L., M.O.) and Institute of Epidemiology and Medical Biometry (B.M.), University of Ulm; Department of Psychiatry and Psychotherapy (J.D.-S., H.F., T.G.), Klinikum Rechts der Isar, Technical University of Munich; Department of Nuclear Medicine (H.B.), Leipzig University Hospital; Department of Neurology (A.D.), Ludwig-Maximilians-University, Munich; Department of Neurology (K.F.), Saarland University, Homburg; Department of Psychiatry and Psychotherapy (K.F.), University of Bonn, Germany; Swiss Epilepsy Center (H.-J.H.), Zurich, Switzerland; Department of Psychiatry and Psychotherapy (H.J.), University Medical Center Hamburg-Eppendorf, Hamburg; AMEOS Klinikum (H.J.), Heiligenhafen; Department of Psychiatry and Psychotherapy (J. Kornhuber, J.M.M.), Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen; Department of Psychiatry and Psychotherapy (M.L.), University of Würzburg; Department of Neurology (J.P.), University of Rostock; DZNE (J.P.), Rostock; Department of Neurodegenerative Diseases and Geriatric Psychiatry (A.S.), University Hospital Bonn; DZNE (A.S.), Bonn; Institute of Human Genetics (A.E.V.), University Medical Center Hamburg-Eppendorf, Hamburg; Department of Psychiatry and Psychotherapy (J.W.), University Medical Center Göttingen; DZNE (J.W.), Göttingen, Germany; iBiMED (J.W.), Medical Sciences Department, University of Aveiro, Portugal; Clinic for Cognitive Neurology (M.L.S.), University Clinic Leipzig; and Max Planck Institute for Human Cognitive and Brain Sciences (M.L.S.), Leipzig, Germany.

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October 2018

Serum neurofilament light chain in behavioral variant frontotemporal dementia.

Neurology 2018 10 12;91(15):e1390-e1401. Epub 2018 Sep 12.

From the Department of Neurology (P.S., S.A.-S., E.S., I.U., C.A.F.v.A., J. Kassubek, B.L., P.O., A.C.L., M.O.) and Institute of Epidemiology and Medical Biometry (B.M.), University of Ulm; Department of Psychiatry and Psychotherapy (J.D.-S., H.F., T.G.), Klinikum Rechts der Isar, Technical University of Munich; Department of Nuclear Medicine (H.B.), Leipzig University Hospital; Department of Neurology (A.D.), Ludwig-Maximilians-University, Munich; Department of Neurology (K.F.), Saarland University, Homburg; Department of Psychiatry and Psychotherapy (K.F.), University of Bonn, Germany; Swiss Epilepsy Center (H.-J.H.), Zurich, Switzerland; Department of Psychiatry and Psychotherapy (H.J.), University Medical Center Hamburg-Eppendorf, Hamburg; AMEOS Klinikum (H.J.), Heiligenhafen; Department of Psychiatry and Psychotherapy (J. Kornhuber, J.M.M.), Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen; Department of Psychiatry and Psychotherapy (M.L.), University of Würzburg; Department of Neurology (J.P.), University of Rostock; DZNE (J.P.), Rostock; Department of Neurodegenerative Diseases and Geriatric Psychiatry (A.S.), University Hospital Bonn; DZNE (A.S.), Bonn; Institute of Human Genetics (A.E.V.), University Medical Center Hamburg-Eppendorf, Hamburg; Department of Psychiatry and Psychotherapy (J.W.), University Medical Center Göttingen; DZNE (J.W.), Göttingen, Germany; iBiMED (J.W.), Medical Sciences Department, University of Aveiro, Portugal; Clinic for Cognitive Neurology (M.L.S.), University Clinic Leipzig; and Max Planck Institute for Human Cognitive and Brain Sciences (M.L.S.), Leipzig, Germany.

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October 2018

Overlap between age-at-onset and disease-progression determinants in Huntington disease.

Neurology 2018 06 9;90(24):e2099-e2106. Epub 2018 May 9.

From the Department of Neurodegenerative Disease (N.A.A., S.J.T.), UCL Huntington's Disease Centre, University College London Institute of Neurology, UK; Departments of Neurology (N.A.A.) and Public Health and Primary Care (J.M.M.v.d.B.), Leiden University Medical Centre, the Netherlands; Department of Population Health Sciences (N.A.A.), German Center for Neurodegenerative Diseases (DZNE), Bonn; and Department of Neurology (G.B.L.), Ulm University Hospital, Germany.

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June 2018

Objective assessment of gait and posture in premanifest and manifest Huntington disease - A multi-center study.

Gait Posture 2018 05 7;62:451-457. Epub 2018 Apr 7.

Department of Neurology, University of Münster, Albert-Schweitzer Campus 1, 48149 Münster, Germany; George-Huntington-Institute, Deilmann-Building IV, Technology-Park, Johann-Krane Weg 27, 48149 Münster, Germany; Institute for Clinical Radiology, University of Münster, Albert-Schweitzer Campus 1, 48149 Münster, Germany; Department of Neurodegenerative Diseases and Hertie-Institute for Clinical Brain, Research, University of Tübingen, Tübingen, Germany. Electronic address:

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May 2018

Survival End Points for Huntington Disease Trials Prior to a Motor Diagnosis.

JAMA Neurol 2017 11;74(11):1352-1360

Huntington's Disease Centre, Department of Neurodegenerative Disease, Institute of Neurology, University College London, Queen Square, London, England.

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November 2017

Revisiting the Logan plot to account for non-negligible blood volume in brain tissue.

EJNMMI Res 2017 Aug 18;7(1):66. Epub 2017 Aug 18.

Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden.

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August 2017

Body weight is a robust predictor of clinical progression in Huntington disease.

Ann Neurol 2017 Sep 22;82(3):479-483. Epub 2017 Aug 22.

Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands.

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September 2017

Eighth International Chorea-Acanthocytosis Symposium: Summary of Workshop Discussion and Action Points.

Tremor Other Hyperkinet Mov (N Y) 2017 15;7:428. Epub 2017 Feb 15.

Department of Neurology, University of Michigan, Ann Arbor, MI, USA; Neurology Service, VAAAHS, University of Michigan, Ann Arbor, MI, USA; Udall Centre, University of Michigan, Ann Arbor, MI, USA; GRECC, VAAAHS, University of Michigan, Ann Arbor, MI, USA,; Michigan Alzheimer's Disease Center, University of Michigan, Ann Arbor, MI, USA.

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February 2017

Neurofilament as a blood marker for diagnosis and monitoring of primary progressive aphasias.

Neurology 2017 Mar 8;88(10):961-969. Epub 2017 Feb 8.

From the Department of Neurology (P.S., E.S., S.A.-S., I.U., B.L., C.A.F.v.A., J. Kassubek, P.O., A.C.L., M.O.), University of Ulm; Department of Psychiatry and Psychotherapy (J.D.-S., H.F., C.R.), Technical University of Munich; Clinic for Cognitive Neurology (M.L.S.), University Clinic Leipzig and Max Planck Institute for Human Cognitive and Brain Sciences, Germany; Swiss Epilepsy Center (H.-J.H.), Zürich, Switzerland; Department of Neurology (K. Fassbender), Saarland University, Homburg; Department of Psychiatry and Psychotherapy (K. Fliessbach), University of Bonn and DZNE; Department of Neurology (J.P.), University of Rostock and German Center for Neurodegenerative Diseases; Department of Psychiatry and Psychotherapy (J. Kornhuber), Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen; Department of Psychiatry and Psychotherapy (A.S.), University of Göttingen; Institute of Human Genetics (A.E.V.), University Medical Center Hamburg-Eppendorf, Hamburg; Department of Psychiatry and Psychotherapy (M.L.), University of Würzburg; and Department of Neurology (A.D.), Ludwig-Maximilians-University Munich, Germany.

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March 2017

Validation of a prognostic index for Huntington's disease.

Mov Disord 2017 02 28;32(2):256-263. Epub 2016 Nov 28.

CHDI Management/CHDI Foundation, Princeton, New Jersey, USA.

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February 2017

Identification of extreme motor phenotypes in Huntington's disease.

Am J Med Genet B Neuropsychiatr Genet 2017 Apr 21;174(3):283-294. Epub 2016 Nov 21.

Department of Neurology, Ulm University, Germany.

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April 2017

Corrigendum to "Neuropsychiatric symptoms are very common in premanifest and early stage Huntington's disease" [Parkinsonism Relat. Disord. 25C (2016) 58-64].

Parkinsonism Relat Disord 2016 10 25;31:161. Epub 2016 Aug 25.

Department of Neurology, Movement Disorders Unit, Hospital de la Santa Creu i Sant Pau, Universitat Aut_onoma de Barcelona, Barcelona, Spain; Sant Pau Institute of Biomedical Research (IIB-Sant Pau), Barcelona, Spain; Centro Investigaci_on Biomedica en Red-Enfermedades Neurodegenerativas (CIBERNED), Spain; Universitat Oberta de Catalunya (UOC), Barcelona, Spain. Electronic address:

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October 2016

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis.

Authors:
Wouter van Rheenen Aleksey Shatunov Annelot M Dekker Russell L McLaughlin Frank P Diekstra Sara L Pulit Rick A A van der Spek Urmo Võsa Simone de Jong Matthew R Robinson Jian Yang Isabella Fogh Perry Tc van Doormaal Gijs H P Tazelaar Max Koppers Anna M Blokhuis William Sproviero Ashley R Jones Kevin P Kenna Kristel R van Eijk Oliver Harschnitz Raymond D Schellevis William J Brands Jelena Medic Androniki Menelaou Alice Vajda Nicola Ticozzi Kuang Lin Boris Rogelj Katarina Vrabec Metka Ravnik-Glavač Blaž Koritnik Janez Zidar Lea Leonardis Leja Dolenc Grošelj Stéphanie Millecamps François Salachas Vincent Meininger Mamede de Carvalho Susana Pinto Jesus S Mora Ricardo Rojas-García Meraida Polak Siddharthan Chandran Shuna Colville Robert Swingler Karen E Morrison Pamela J Shaw John Hardy Richard W Orrell Alan Pittman Katie Sidle Pietro Fratta Andrea Malaspina Simon Topp Susanne Petri Susanne Abdulla Carsten Drepper Michael Sendtner Thomas Meyer Roel A Ophoff Kim A Staats Martina Wiedau-Pazos Catherine Lomen-Hoerth Vivianna M Van Deerlin John Q Trojanowski Lauren Elman Leo McCluskey A Nazli Basak Ceren Tunca Hamid Hamzeiy Yesim Parman Thomas Meitinger Peter Lichtner Milena Radivojkov-Blagojevic Christian R Andres Cindy Maurel Gilbert Bensimon Bernhard Landwehrmeyer Alexis Brice Christine A M Payan Safaa Saker-Delye Alexandra Dürr Nicholas W Wood Lukas Tittmann Wolfgang Lieb Andre Franke Marcella Rietschel Sven Cichon Markus M Nöthen Philippe Amouyel Christophe Tzourio Jean-François Dartigues Andre G Uitterlinden Fernando Rivadeneira Karol Estrada Albert Hofman Charles Curtis Hylke M Blauw Anneke J van der Kooi Marianne de Visser An Goris Markus Weber Christopher E Shaw Bradley N Smith Orietta Pansarasa Cristina Cereda Roberto Del Bo Giacomo P Comi Sandra D'Alfonso Cinzia Bertolin Gianni Sorarù Letizia Mazzini Viviana Pensato Cinzia Gellera Cinzia Tiloca Antonia Ratti Andrea Calvo Cristina Moglia Maura Brunetti Simona Arcuti Rosa Capozzo Chiara Zecca Christian Lunetta Silvana Penco Nilo Riva Alessandro Padovani Massimiliano Filosto Bernard Muller Robbert Jan Stuit Ian Blair Katharine Zhang Emily P McCann Jennifer A Fifita Garth A Nicholson Dominic B Rowe Roger Pamphlett Matthew C Kiernan Julian Grosskreutz Otto W Witte Thomas Ringer Tino Prell Beatrice Stubendorff Ingo Kurth Christian A Hübner P Nigel Leigh Federico Casale Adriano Chio Ettore Beghi Elisabetta Pupillo Rosanna Tortelli Giancarlo Logroscino John Powell Albert C Ludolph Jochen H Weishaupt Wim Robberecht Philip Van Damme Lude Franke Tune H Pers Robert H Brown Jonathan D Glass John E Landers Orla Hardiman Peter M Andersen Philippe Corcia Patrick Vourc'h Vincenzo Silani Naomi R Wray Peter M Visscher Paul I W de Bakker Michael A van Es R Jeroen Pasterkamp Cathryn M Lewis Gerome Breen Ammar Al-Chalabi Leonard H van den Berg Jan H Veldink

Nat Genet 2016 09 25;48(9):1043-8. Epub 2016 Jul 25.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.

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September 2016

Neuropsychiatric symptoms are very common in premanifest and early stage Huntington's Disease.

Parkinsonism Relat Disord 2016 Apr 11;25:58-64. Epub 2016 Feb 11.

Department of Neurology, Movement Disorders Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Sant Pau Institute of Biomedical Research (IIB-Sant Pau), Barcelona, Spain; Centro Investigación Biomedica en Red-Enfermedades Neurodegenerativas (CIBERNED), Spain; Universitat Oberta de Catalunya (UOC), Barcelona, Spain. Electronic address:

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April 2016

Abnormal cerebellar volume and corticocerebellar dysfunction in early manifest Huntington's disease.

J Neurol 2015 28;262(4):859-69. Epub 2015 Jan 28.

Department of Psychiatry, Psychotherapy and Psychosomatics, Saarland University, Kirrberger Str. 1, 66421, Homburg, Germany,

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January 2016

Update on Huntington's disease: advances in care and emerging therapeutic options.

Parkinsonism Relat Disord 2015 Mar 19;21(3):169-78. Epub 2014 Dec 19.

Department of Neurology, University of Ulm, Ulm, Germany.

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March 2015

Prodromal Huntington disease as a model for functional compensation of early neurodegeneration.

PLoS One 2014 26;9(12):e114569. Epub 2014 Dec 26.

Department of Psychiatry, Ulm University, Leimgrubenweg 12-14, 89522, Ulm, Germany.

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August 2015

Visual system integrity and cognition in early Huntington's disease.

Eur J Neurosci 2014 Jul 3;40(2):2417-26. Epub 2014 Apr 3.

Department of General Psychiatry, Center for Psychosocial Medicine, University of Heidelberg, Voßstraße 4, Heidelberg, 69115, Germany.

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July 2014

Longitudinal task-negative network analyses in preclinical Huntington's disease.

Eur Arch Psychiatry Clin Neurosci 2014 Sep 27;264(6):493-505. Epub 2013 Sep 27.

Center for Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Voßstraße 4, 69115, Heidelberg, Germany,

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September 2014

Longitudinal task-negative network analyses in preclinical Huntington's disease.

Eur Arch Psychiatry Clin Neurosci 2014 Sep 27;264(6):493-505. Epub 2013 Sep 27.

Center for Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Voßstraße 4, 69115, Heidelberg, Germany,

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September 2014

The influence of gender on phenotype and disease progression in patients with Huntington's disease.

Parkinsonism Relat Disord 2013 Feb 25;19(2):192-7. Epub 2012 Oct 25.

Poznan University of Medical Sciences, Department of Social Medicine, Rokietnicka Str., No. 5 C, 60-806 Poznan, Poland.

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February 2013

Brain structure in preclinical Huntington's disease: a multi-method approach.

Neurodegener Dis 2013 17;12(1):13-22. Epub 2012 Aug 17.

Center of Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Heidelberg, Germany.

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January 2014

Default-mode network changes in preclinical Huntington's disease.

Exp Neurol 2012 Sep 25;237(1):191-8. Epub 2012 Jun 25.

Center for Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Germany.

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September 2012

Current Pharmacological Management in Juvenile Huntington's Disease.

PLoS Curr 2012 Feb 15;4:RRN1304. Epub 2012 Feb 15.

Department of Clinical Genetics, Sheffield Children's Hospital, Sheffield UK S10 2TH; Neurogenetics and Rare Diseases Centre, IRCCS Neuromed, Pozzilli (IS), Italy.; University of Cambridge; Department of Clinical Neurophysiology, Institute of Psychiatry and Naurology, Warsaw, Poland and Dept. of Neurology, University of Ulm, Ulm, Germany.

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February 2012

Stability effects on results of diffusion tensor imaging analysis by reduction of the number of gradient directions due to motion artifacts: an application to presymptomatic Huntington's disease.

PLoS Curr 2011 Dec 12;3:RRN1292. Epub 2011 Dec 12.

Dept. of Neurology, University of Ulm, Ulm, Germany; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK and Freiburg Brain Imaging, Department of Psychiatry and Psychotherapy. University of Freiburg.

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December 2011

Stability effects on results of diffusion tensor imaging analysis by reduction of the number of gradient directions due to motion artifacts: an application to presymptomatic Huntington's disease.

PLoS Curr 2011 Dec 12;3:RRN1292. Epub 2011 Dec 12.

Dept. of Neurology, University of Ulm, Ulm, Germany; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK and Freiburg Brain Imaging, Department of Psychiatry and Psychotherapy. University of Freiburg.

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December 2011

Huntington's disease: new aspects on phenotype and genotype.

Parkinsonism Relat Disord 2012 Jan;18 Suppl 1:S107-9

Department of Neurology, West China Hospital, Sichuan University, Sichuan, PR China.

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January 2012

Rate of change in early Huntington's disease: a clinicometric analysis.

Mov Disord 2012 Jan 17;27(1):118-24. Epub 2011 Nov 17.

Department of Neurology, University of Ulm, Ulm, Germany.

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January 2012

Longitudinal functional magnetic resonance imaging of cognition in preclinical Huntington's disease.

Exp Neurol 2011 Oct 25;231(2):214-22. Epub 2011 Jun 25.

Center of Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Germany.

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October 2011

Caudate nucleus and insular activation during a pain suppression paradigm comparing thermal and electrical stimulation.

Open Neuroimag J 2011 18;5:1-8. Epub 2011 Jan 18.

Department of Diagnostic and Interventional Radiology, University Hospital, Ulm, Germany.

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July 2011

Quantifying change in individual subjects affected by frontotemporal lobar degeneration using automated longitudinal MRI volumetry.

Hum Brain Mapp 2012 Jul 26;33(7):1526-35. Epub 2011 May 26.

Department of Psychiatry and Psychotherapy, Center of Geriatrics and Gerontology Freiburg, Freiburg Brain Imaging, University of Freiburg, Freiburg, Germany.

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July 2012

Magnetic resonance perfusion imaging of resting-state cerebral blood flow in preclinical Huntington's disease.

J Cereb Blood Flow Metab 2011 Sep 11;31(9):1908-18. Epub 2011 May 11.

Center of Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Heidelberg, Germany.

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September 2011

Utilisation of Healthcare and Associated Services in Huntington's disease: a data mining study.

PLoS Curr 2011 Jan 21;3:RRN1206. Epub 2011 Jan 21.

Department of Physiotherapy, Cardiff University, Ty Dewi Sant, Heath Park, Cardiff, UK; BGL Group; Health, Sport and Science, University of Glamorgan Pontypridd UK; Universitätsklinikum Ulm, Neurologie; Istitutodi Neurologia, Istituto di neurologia, Università Cattolica del Sacro Cuore, Roma, Italy and Cardiff University.

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January 2011