Bernhard Landwehrmeyer

Bernhard Landwehrmeyer

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Bernhard Landwehrmeyer

Bernhard Landwehrmeyer

Publications by authors named "Bernhard Landwehrmeyer"

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96Publications

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PET molecular imaging of phosphodiesterase 10A: An early biomarker of Huntington's disease progression.

Authors:
Patrik Fazio Cheryl J Fitzer-Attas Ladislav Mrzljak Juliana Bronzova Sangram Nag John H Warner Bernhard Landwehrmeyer Nabil Al-Tawil Christer Halldin Anton Forsberg Jennifer Ware Valentina Dilda Andrew Wood Cristina Sampaio Andrea Varrone

Mov Disord 2020 Jan 22. Epub 2020 Jan 22.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Sweden.

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http://dx.doi.org/10.1002/mds.27963DOI Listing
January 2020

Olfactory screening of Parkinson's Disease patients and healthy subjects in China and Germany: A study of cross-cultural adaptation of the Sniffin' Sticks 12-identification test.

Authors:
Elmar H Pinkhardt Huijing Liu Di Ma Jing Chen Adrian Pachollek Martin S Kunz Jan Kassubek Albert C Ludolph Yining Huang Haibo Chen G Bernhard Landwehrmeyer Zhaoxia Wang Wen Su

PLoS One 2019 8;14(11):e0224331. Epub 2019 Nov 8.

Neurology Department, Beijing Hospital, National Center of Gerontology, China, Dong Dan, Beijing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224331PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839844PMC
November 2019

Movement Disorder Society Task Force Viewpoint: Huntington's Disease Diagnostic Categories.

Authors:
Christopher A Ross Ralf Reilmann Francisco Cardoso Elizabeth A McCusker Claudia M Testa Julie C Stout Blair R Leavitt Zhong Pei Bernhard Landwehrmeyer Asuncion Martinez Jamie Levey Teresa Srajer Jee Bang Sarah J Tabrizi

Mov Disord Clin Pract 2019 Sep 23;6(7):541-546. Epub 2019 Aug 23.

Huntington's Disease Centre, University College London Queen Square Institute of Neurology London United Kingdom.

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http://dx.doi.org/10.1002/mdc3.12808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749806PMC
September 2019

Unraveling corticobasal syndrome and alien limb syndrome with structural brain imaging.

Authors:
Franziska Albrecht Karsten Mueller Tommaso Ballarini Leonie Lampe Janine Diehl-Schmid Klaus Fassbender Klaus Fliessbach Holger Jahn Robert Jech Jan Kassubek Johannes Kornhuber Bernhard Landwehrmeyer Martin Lauer Albert C Ludolph Epameinondas Lyros Johannes Prudlo Anja Schneider Matthis Synofzik Jens Wiltfang Adrian Danek Markus Otto Matthias L Schroeter

Cortex 2019 Aug 25;117:33-40. Epub 2019 Feb 25.

Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Clinic of Cognitive Neurology, University of Leipzig, Germany; FTLD Consortium Germany, Germany.

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http://dx.doi.org/10.1016/j.cortex.2019.02.015DOI Listing
August 2019

Association of CAG Repeats With Long-term Progression in Huntington Disease.

Authors:
Douglas R Langbehn Julie C Stout Sarah Gregory James A Mills Alexandra Durr Blair R Leavitt Raymund A C Roos Jeffrey D Long Gail Owen Hans J Johnson Beth Borowsky David Craufurd Ralf Reilmann G Bernhard Landwehrmeyer Rachael I Scahill Sarah J Tabrizi

JAMA Neurol 2019 Aug 12. Epub 2019 Aug 12.

Huntington's Disease Centre, UCL Institute of Neurology, University College London, Queen Square, London, United Kingdom.

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http://dx.doi.org/10.1001/jamaneurol.2019.2368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692683PMC
August 2019

An International Validation of a Clinical Tool to Assess Carers' Quality of Life in Huntington's Disease.

Authors:
Aimee Aubeeluck Edward J N Stupple Malcolm B Schofield Alis C Hughes Lucienne van der Meer Bernhard Landwehrmeyer Aileen K Ho

Front Psychol 2019 23;10:1658. Epub 2019 Jul 23.

School of Psychology and Clinical Language Sciences, University of Reading, Reading, United Kingdom.

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http://dx.doi.org/10.3389/fpsyg.2019.01658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676956PMC
July 2019

Combined cerebral atrophy score in Huntington's disease based on atlas-based MRI volumetry: Sample size calculations for clinical trials.

Authors:
Hans-Peter Müller Hans-Jürgen Huppertz Jens Dreyhaupt Albert C Ludolph Sarah J Tabrizi Raymund A C Roos Alexandra Durr G Bernhard Landwehrmeyer Jan Kassubek

Parkinsonism Relat Disord 2019 06 5;63:179-184. Epub 2019 Feb 5.

Department of Neurology, University of Ulm, Germany.

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http://dx.doi.org/10.1016/j.parkreldis.2019.02.004DOI Listing
June 2019

Targeting Huntingtin Expression in Patients with Huntington's Disease.

Authors:
Sarah J Tabrizi Blair R Leavitt G Bernhard Landwehrmeyer Edward J Wild Carsten Saft Roger A Barker Nick F Blair David Craufurd Josef Priller Hugh Rickards Anne Rosser Holly B Kordasiewicz Christian Czech Eric E Swayze Daniel A Norris Tiffany Baumann Irene Gerlach Scott A Schobel Erika Paz Anne V Smith C Frank Bennett Roger M Lane

N Engl J Med 2019 06 6;380(24):2307-2316. Epub 2019 May 6.

From University College London (UCL) Huntington's Disease Centre, Department of Neurodegenerative Disease, Queen Square Institute of Neurology, UCL, and the U.K. Dementia Research Institute at UCL, London (S.J.T., E.J.W.), the Department of Clinical Neuroscience, Addenbrooke's Hospital, University of Cambridge, Cambridge (R.A.B., N.F.B.), Manchester Centre for Genomic Medicine, St. Mary's Hospital, Manchester University NHS Foundation Trust, and the Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester (D.C.), the University of Edinburgh and the U.K. Dementia Research Institute, Edinburgh (J.P.), the Institute of Clinical Sciences, College of Medical and Dental Sciences, University Hospital Birmingham, Birmingham (H.R.), and the Cardiff University Brain Repair Group, Brain Repair and Intracranial Neurotherapeutics Unit, Neuroscience and Mental Health Research Institute and School of Biosciences, Cardiff (A.R.) - all in the United Kingdom; the Centre for Huntington's Disease, Department of Medical Genetics, and the Division of Neurology, Department of Medicine, University of British Columbia, and the Centre for Molecular Medicine and Therapeutics, B.C. Children's Hospital, Vancouver, Canada (B.R.L.); the Department of Neurology, Ulm University, Huntington's Disease Centre, Ulm (G.B.L.), the Department of Neurology, Huntington Center North Rhine-Westphalia, Ruhr University Bochum, St. Josef-Hospital, Bochum (C.S.), and the Department of Neuropsychiatry, Charité-Universitätsmedizin Berlin, Deutsches Zentrum für Neurodegenerative Erkrankungen, Berlin (J.P.) - all in Germany; Ionis Pharmaceuticals, Carlsbad, CA (H.B.K., E.E.S., D.A.N., T.B., E.P., A.V.S., C.F.B., R.M.L.); and F. Hoffmann-La Roche, Basel, Switzerland (C.C., I.G., S.A.S.).

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http://dx.doi.org/10.1056/NEJMoa1900907DOI Listing
June 2019

Meaningful and Measurable Health Domains in Huntington's Disease: Large-Scale Validation of the Huntington's Disease Health-Related Quality of Life Questionnaire Across Severity Stages.

Authors:
Aileen K Ho Mike C Horton G Bernhard Landwehrmeyer Jean-Marc Burgunder Alan Tennant

Value Health 2019 06;22(6):712-720

Swiss Paraplegic Research, Nottwil, Switzerland.

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http://dx.doi.org/10.1016/j.jval.2019.01.016DOI Listing
June 2019

Defining pediatric huntington disease: Time to abandon the term Juvenile Huntington Disease?

Authors:
Oliver W J Quarrell Martha A Nance Peg Nopoulos Ralf Reilmann Mayke Oosterloo Sarah J Tabrizi Hannah Furby Carsten Saft Raymund A C Roos Ferdinando Squitieri G Bernhard Landwehrmeyer Jean-Marc Burgunder

Mov Disord 2019 04 20;34(4):584-585. Epub 2019 Feb 20.

Swiss HD Center, Neurozentrum Siloah and Department of Neurology, University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1002/mds.27640DOI Listing
April 2019

Safety and efficacy of pridopidine in patients with Huntington's disease (PRIDE-HD): a phase 2, randomised, placebo-controlled, multicentre, dose-ranging study.

Authors:
Ralf Reilmann Andrew McGarry Igor D Grachev Juha-Matti Savola Beth Borowsky Eli Eyal Nicholas Gross Douglas Langbehn Robin Schubert Anna Teige Wickenberg Spyros Papapetropoulos Michael Hayden Ferdinando Squitieri Karl Kieburtz G Bernhard Landwehrmeyer

Lancet Neurol 2019 Feb 15;18(2):165-176. Epub 2018 Dec 15.

Department of Neurology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1016/S1474-4422(18)30391-0DOI Listing
February 2019

Specific serum and CSF microRNA profiles distinguish sporadic behavioural variant of frontotemporal dementia compared with Alzheimer patients and cognitively healthy controls.

Authors:
Johannes Denk Felix Oberhauser Johannes Kornhuber Jens Wiltfang Klaus Fassbender Matthias L Schroeter Alexander E Volk Janine Diehl-Schmid Johannes Prudlo Adrian Danek Bernhard Landwehrmeyer Martin Lauer Markus Otto Holger Jahn

PLoS One 2018 10;13(5):e0197329. Epub 2018 May 10.

Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197329PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945001PMC
November 2018

Serum neurofilament light chain in behavioral variant frontotemporal dementia.

Authors:
Petra Steinacker Sarah Anderl-Straub Janine Diehl-Schmid Elisa Semler Ingo Uttner Christine A F von Arnim Henryk Barthel Adrian Danek Klaus Fassbender Klaus Fliessbach Hans Foerstl Timo Grimmer Hans-Jürgen Huppertz Holger Jahn Jan Kassubek Johannes Kornhuber Bernhard Landwehrmeyer Martin Lauer Juan Manuel Maler Benjamin Mayer Patrick Oeckl Johannes Prudlo Anja Schneider Alexander E Volk Jens Wiltfang Matthias L Schroeter Albert C Ludolph Markus Otto

Neurology 2018 10 12;91(15):e1390-e1401. Epub 2018 Sep 12.

From the Department of Neurology (P.S., S.A.-S., E.S., I.U., C.A.F.v.A., J. Kassubek, B.L., P.O., A.C.L., M.O.) and Institute of Epidemiology and Medical Biometry (B.M.), University of Ulm; Department of Psychiatry and Psychotherapy (J.D.-S., H.F., T.G.), Klinikum Rechts der Isar, Technical University of Munich; Department of Nuclear Medicine (H.B.), Leipzig University Hospital; Department of Neurology (A.D.), Ludwig-Maximilians-University, Munich; Department of Neurology (K.F.), Saarland University, Homburg; Department of Psychiatry and Psychotherapy (K.F.), University of Bonn, Germany; Swiss Epilepsy Center (H.-J.H.), Zurich, Switzerland; Department of Psychiatry and Psychotherapy (H.J.), University Medical Center Hamburg-Eppendorf, Hamburg; AMEOS Klinikum (H.J.), Heiligenhafen; Department of Psychiatry and Psychotherapy (J. Kornhuber, J.M.M.), Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen; Department of Psychiatry and Psychotherapy (M.L.), University of Würzburg; Department of Neurology (J.P.), University of Rostock; DZNE (J.P.), Rostock; Department of Neurodegenerative Diseases and Geriatric Psychiatry (A.S.), University Hospital Bonn; DZNE (A.S.), Bonn; Institute of Human Genetics (A.E.V.), University Medical Center Hamburg-Eppendorf, Hamburg; Department of Psychiatry and Psychotherapy (J.W.), University Medical Center Göttingen; DZNE (J.W.), Göttingen, Germany; iBiMED (J.W.), Medical Sciences Department, University of Aveiro, Portugal; Clinic for Cognitive Neurology (M.L.S.), University Clinic Leipzig; and Max Planck Institute for Human Cognitive and Brain Sciences (M.L.S.), Leipzig, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000006318DOI Listing
October 2018

Serum neurofilament light chain in behavioral variant frontotemporal dementia.

Authors:
Petra Steinacker Sarah Anderl-Straub Janine Diehl-Schmid Elisa Semler Ingo Uttner Christine A F von Arnim Henryk Barthel Adrian Danek Klaus Fassbender Klaus Fliessbach Hans Foerstl Timo Grimmer Hans-Jürgen Huppertz Holger Jahn Jan Kassubek Johannes Kornhuber Bernhard Landwehrmeyer Martin Lauer Juan Manuel Maler Benjamin Mayer Patrick Oeckl Johannes Prudlo Anja Schneider Alexander E Volk Jens Wiltfang Matthias L Schroeter Albert C Ludolph Markus Otto

Neurology 2018 10 12;91(15):e1390-e1401. Epub 2018 Sep 12.

From the Department of Neurology (P.S., S.A.-S., E.S., I.U., C.A.F.v.A., J. Kassubek, B.L., P.O., A.C.L., M.O.) and Institute of Epidemiology and Medical Biometry (B.M.), University of Ulm; Department of Psychiatry and Psychotherapy (J.D.-S., H.F., T.G.), Klinikum Rechts der Isar, Technical University of Munich; Department of Nuclear Medicine (H.B.), Leipzig University Hospital; Department of Neurology (A.D.), Ludwig-Maximilians-University, Munich; Department of Neurology (K.F.), Saarland University, Homburg; Department of Psychiatry and Psychotherapy (K.F.), University of Bonn, Germany; Swiss Epilepsy Center (H.-J.H.), Zurich, Switzerland; Department of Psychiatry and Psychotherapy (H.J.), University Medical Center Hamburg-Eppendorf, Hamburg; AMEOS Klinikum (H.J.), Heiligenhafen; Department of Psychiatry and Psychotherapy (J. Kornhuber, J.M.M.), Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen; Department of Psychiatry and Psychotherapy (M.L.), University of Würzburg; Department of Neurology (J.P.), University of Rostock; DZNE (J.P.), Rostock; Department of Neurodegenerative Diseases and Geriatric Psychiatry (A.S.), University Hospital Bonn; DZNE (A.S.), Bonn; Institute of Human Genetics (A.E.V.), University Medical Center Hamburg-Eppendorf, Hamburg; Department of Psychiatry and Psychotherapy (J.W.), University Medical Center Göttingen; DZNE (J.W.), Göttingen, Germany; iBiMED (J.W.), Medical Sciences Department, University of Aveiro, Portugal; Clinic for Cognitive Neurology (M.L.S.), University Clinic Leipzig; and Max Planck Institute for Human Cognitive and Brain Sciences (M.L.S.), Leipzig, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000006318DOI Listing
October 2018

Overlap between age-at-onset and disease-progression determinants in Huntington disease.

Authors:
N Ahmad Aziz Jorien M M van der Burg Sarah J Tabrizi G Bernhard Landwehrmeyer

Neurology 2018 06 9;90(24):e2099-e2106. Epub 2018 May 9.

From the Department of Neurodegenerative Disease (N.A.A., S.J.T.), UCL Huntington's Disease Centre, University College London Institute of Neurology, UK; Departments of Neurology (N.A.A.) and Public Health and Primary Care (J.M.M.v.d.B.), Leiden University Medical Centre, the Netherlands; Department of Population Health Sciences (N.A.A.), German Center for Neurodegenerative Diseases (DZNE), Bonn; and Department of Neurology (G.B.L.), Ulm University Hospital, Germany.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000005690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996832PMC
June 2018

Objective assessment of gait and posture in premanifest and manifest Huntington disease - A multi-center study.

Authors:
Heike Beckmann Stefan Bohlen Carsten Saft Rainer Hoffmann Joachim Gerss Lisa Muratori E Bernd Ringelstein G Bernhard Landwehrmeyer Ralf Reilmann

Gait Posture 2018 05 7;62:451-457. Epub 2018 Apr 7.

Department of Neurology, University of Münster, Albert-Schweitzer Campus 1, 48149 Münster, Germany; George-Huntington-Institute, Deilmann-Building IV, Technology-Park, Johann-Krane Weg 27, 48149 Münster, Germany; Institute for Clinical Radiology, University of Münster, Albert-Schweitzer Campus 1, 48149 Münster, Germany; Department of Neurodegenerative Diseases and Hertie-Institute for Clinical Brain, Research, University of Tübingen, Tübingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.gaitpost.2018.03.039DOI Listing
May 2018

The contribution of gender differences in motor, behavioral and cognitive features to functional capacity, independence and quality of life in patients with Huntington's disease.

Authors:
Daniel Zielonka Michał Ren Giuseppe De Michele Raymund A C Roos Ferdinando Squitieri Anna Rita Bentivoglio Jerzy T Marcinkowski G Bernhard Landwehrmeyer

Parkinsonism Relat Disord 2018 04 5;49:42-47. Epub 2018 Jan 5.

Universitätsklinik Ulm, Abteilung Neurologie, Ulm, Germany.

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http://dx.doi.org/10.1016/j.parkreldis.2018.01.006DOI Listing
April 2018

A language-based sum score for the course and therapeutic intervention in primary progressive aphasia.

Authors:
Elisa Semler Sarah Anderl-Straub Ingo Uttner Janine Diehl-Schmid Adrian Danek Beate Einsiedler Klaus Fassbender Klaus Fliessbach Hans-Jürgen Huppertz Holger Jahn Johannes Kornhuber Bernhard Landwehrmeyer Martin Lauer Rainer Muche Johannes Prudlo Anja Schneider Matthias L Schroeter Albert C Ludolph Markus Otto

Alzheimers Res Ther 2018 04 25;10(1):41. Epub 2018 Apr 25.

Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.

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http://dx.doi.org/10.1186/s13195-018-0345-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922300PMC
April 2018

Chitotriosidase (CHIT1) is increased in microglia and macrophages in spinal cord of amyotrophic lateral sclerosis and cerebrospinal fluid levels correlate with disease severity and progression.

Authors:
Petra Steinacker Federico Verde Lubin Fang Emily Feneberg Patrick Oeckl Sigrun Roeber Sarah Anderl-Straub Adrian Danek Janine Diehl-Schmid Klaus Fassbender Klaus Fliessbach Hans Foerstl Armin Giese Holger Jahn Jan Kassubek Johannes Kornhuber G Bernhard Landwehrmeyer Martin Lauer Elmar Hans Pinkhardt Johannes Prudlo Angela Rosenbohm Anja Schneider Matthias L Schroeter Hayrettin Tumani Christine A F von Arnim Jochen Weishaupt Patrick Weydt Albert C Ludolph Deniz Yilmazer Hanke Markus Otto

J Neurol Neurosurg Psychiatry 2018 03 15;89(3):239-247. Epub 2017 Nov 15.

Department of Neurology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1136/jnnp-2017-317138DOI Listing
March 2018

The contribution of gender differences in motor, behavioral and cognitive features to functional capacity, independence and quality of life in patients with Huntington's disease.

Authors:
Daniel Zielonka Michał Ren Giuseppe De Michele Raymund A C Roos Ferdinando Squitieri Anna Rita Bentivoglio Jerzy T Marcinkowski G Bernhard Landwehrmeyer

Parkinsonism Relat Disord 2018 04 5;49:42-47. Epub 2018 Jan 5.

Universitätsklinik Ulm, Abteilung Neurologie, Ulm, Germany.

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http://dx.doi.org/10.1016/j.parkreldis.2018.01.006DOI Listing
April 2018

Atrophy in the Thalamus But Not Cerebellum Is Specific for FTD and ALS Patients - An Atlas-Based Volumetric MRI Study.

Authors:
Sonja Schönecker Christiane Neuhofer Markus Otto Albert Ludolph Jan Kassubek Bernhard Landwehrmeyer Sarah Anderl-Straub Elisa Semler Janine Diehl-Schmid Catharina Prix Christian Vollmar Juan Fortea Hans-Jürgen Huppertz Thomas Arzberger Dieter Edbauer Berend Feddersen Marianne Dieterich Matthias L Schroeter Alexander E Volk Klaus Fließbach Anja Schneider Johannes Kornhuber Manuel Maler Johannes Prudlo Holger Jahn Tobias Boeckh-Behrens Adrian Danek Thomas Klopstock Johannes Levin

Front Aging Neurosci 2018 15;10:45. Epub 2018 Mar 15.

Department of Neurology, Ludwig Maximilians Universität München, Munich, Germany.

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http://dx.doi.org/10.3389/fnagi.2018.00045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863593PMC
March 2018

Predicting primary progressive aphasias with support vector machine approaches in structural MRI data.

Authors:
Sandrine Bisenius Karsten Mueller Janine Diehl-Schmid Klaus Fassbender Timo Grimmer Frank Jessen Jan Kassubek Johannes Kornhuber Bernhard Landwehrmeyer Albert Ludolph Anja Schneider Sarah Anderl-Straub Katharina Stuke Adrian Danek Markus Otto Matthias L Schroeter

Neuroimage Clin 2017 6;14:334-343. Epub 2017 Feb 6.

Max Planck Institute for Human Cognitive and Brain Sciences & Clinic for Cognitive Neurology, University Hospital Leipzig, Germany.

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http://dx.doi.org/10.1016/j.nicl.2017.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310935PMC
November 2017

Survival End Points for Huntington Disease Trials Prior to a Motor Diagnosis.

Authors:
Jeffrey D Long James A Mills Blair R Leavitt Alexandra Durr Raymund A Roos Julie C Stout Ralf Reilmann Bernhard Landwehrmeyer Sarah Gregory Rachael I Scahill Douglas R Langbehn Sarah J Tabrizi

JAMA Neurol 2017 11;74(11):1352-1360

Huntington's Disease Centre, Department of Neurodegenerative Disease, Institute of Neurology, University College London, Queen Square, London, England.

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http://dx.doi.org/10.1001/jamaneurol.2017.2107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710578PMC
November 2017

Body weight is a robust predictor of clinical progression in Huntington disease.

Authors:
Jorien M M van der Burg Sarah L Gardiner Albert C Ludolph G Bernhard Landwehrmeyer Raymund A C Roos N Ahmad Aziz

Ann Neurol 2017 Sep 22;82(3):479-483. Epub 2017 Aug 22.

Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1002/ana.25007DOI Listing
September 2017

Bupropion for the treatment of apathy in Huntington's disease: A multicenter, randomised, double-blind, placebo-controlled, prospective crossover trial.

Authors:
Harald Gelderblom Torsten Wüstenberg Tim McLean Lisanne Mütze Wilhelm Fischer Carsten Saft Rainer Hoffmann Sigurd Süssmuth Peter Schlattmann Erik van Duijn Bernhard Landwehrmeyer Josef Priller

PLoS One 2017 21;12(3):e0173872. Epub 2017 Mar 21.

Department of Neuropsychiatry, Charité-Universitätsmedizin Berlin, Berlin, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0173872PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360242PMC
August 2017

Revisiting the Logan plot to account for non-negligible blood volume in brain tissue.

Authors:
Martin Schain Patrik Fazio Ladislav Mrzljak Nahid Amini Nabil Al-Tawil Cheryl Fitzer-Attas Juliana Bronzova Bernhard Landwehrmeyer Christina Sampaio Christer Halldin Andrea Varrone

EJNMMI Res 2017 Aug 18;7(1):66. Epub 2017 Aug 18.

Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s13550-017-0314-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561763PMC
August 2017

Poly-GP in cerebrospinal fluid links -associated dipeptide repeat expression to the asymptomatic phase of ALS/FTD.

Authors:
Carina Lehmer Patrick Oeckl Jochen H Weishaupt Alexander E Volk Janine Diehl-Schmid Matthias L Schroeter Martin Lauer Johannes Kornhuber Johannes Levin Klaus Fassbender Bernhard Landwehrmeyer Martin H Schludi Thomas Arzberger Elisabeth Kremmer Andrew Flatley Regina Feederle Petra Steinacker Patrick Weydt Albert C Ludolph Dieter Edbauer Markus Otto

EMBO Mol Med 2017 07;9(7):859-868

Department of Neurology, Ulm University Hospital, Ulm, Germany

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http://dx.doi.org/10.15252/emmm.201607486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494528PMC
July 2017

Fast-to-Slow Transition of Skeletal Muscle Contractile Function and Corresponding Changes in Myosin Heavy and Light Chain Formation in the R6/2 Mouse Model of Huntington's Disease.

Authors:
Tanja Hering Peter Braubach G Bernhard Landwehrmeyer Katrin S Lindenberg Werner Melzer

PLoS One 2016 7;11(11):e0166106. Epub 2016 Nov 7.

Institute of Applied Physiology, Ulm University, Ulm, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0166106PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098792PMC
June 2017

Patterns of age related changes for phosphodiesterase type-10A in comparison with dopamine D receptors and sub-cortical volumes in the human basal ganglia: A PET study with F-MNI-659 and C-raclopride with correction for partial volume effect.

Authors:
Patrik Fazio Martin Schain Ladislav Mrzljak Nahid Amini Sangram Nag Nabil Al-Tawil Cheryl J Fitzer-Attas Juliana Bronzova Bernhard Landwehrmeyer Cristina Sampaio Christer Halldin Andrea Varrone

Neuroimage 2017 05 28;152:330-339. Epub 2017 Feb 28.

Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neuroimage.2017.02.047DOI Listing
May 2017

Identification of extreme motor phenotypes in Huntington's disease.

Authors:
Ulrike Braisch Birgit Hay Rainer Muche Dietrich Rothenbacher G Bernhard Landwehrmeyer Jeffrey D Long Michael Orth

Am J Med Genet B Neuropsychiatr Genet 2017 Apr 21;174(3):283-294. Epub 2016 Nov 21.

Department of Neurology, Ulm University, Germany.

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http://dx.doi.org/10.1002/ajmg.b.32514DOI Listing
April 2017

High-resolution respirometry of fine-needle muscle biopsies in pre-manifest Huntington's disease expansion mutation carriers shows normal mitochondrial respiratory function.

Authors:
Eva Buck Martina Zügel Uwe Schumann Tamara Merz Anja M Gumpp Anke Witting Jürgen M Steinacker G Bernhard Landwehrmeyer Patrick Weydt Enrico Calzia Katrin S Lindenberg

PLoS One 2017 13;12(4):e0175248. Epub 2017 Apr 13.

Department of Neurology, Ulm University, Ulm, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0175248PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390997PMC
April 2017

Neurofilament as a blood marker for diagnosis and monitoring of primary progressive aphasias.

Authors:
Petra Steinacker Elisa Semler Sarah Anderl-Straub Janine Diehl-Schmid Matthias L Schroeter Ingo Uttner Hans Foerstl Bernhard Landwehrmeyer Christine A F von Arnim Jan Kassubek Patrick Oeckl Hans-Jürgen Huppertz Klaus Fassbender Klaus Fliessbach Johannes Prudlo Carola Roßmeier Johannes Kornhuber Anja Schneider Alexander E Volk Martin Lauer Adrian Danek Albert C Ludolph Markus Otto

Neurology 2017 Mar 8;88(10):961-969. Epub 2017 Feb 8.

From the Department of Neurology (P.S., E.S., S.A.-S., I.U., B.L., C.A.F.v.A., J. Kassubek, P.O., A.C.L., M.O.), University of Ulm; Department of Psychiatry and Psychotherapy (J.D.-S., H.F., C.R.), Technical University of Munich; Clinic for Cognitive Neurology (M.L.S.), University Clinic Leipzig and Max Planck Institute for Human Cognitive and Brain Sciences, Germany; Swiss Epilepsy Center (H.-J.H.), Zürich, Switzerland; Department of Neurology (K. Fassbender), Saarland University, Homburg; Department of Psychiatry and Psychotherapy (K. Fliessbach), University of Bonn and DZNE; Department of Neurology (J.P.), University of Rostock and German Center for Neurodegenerative Diseases; Department of Psychiatry and Psychotherapy (J. Kornhuber), Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen; Department of Psychiatry and Psychotherapy (A.S.), University of Göttingen; Institute of Human Genetics (A.E.V.), University Medical Center Hamburg-Eppendorf, Hamburg; Department of Psychiatry and Psychotherapy (M.L.), University of Würzburg; and Department of Neurology (A.D.), Ludwig-Maximilians-University Munich, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000003688DOI Listing
March 2017

Intact sensory-motor network structure and function in far from onset premanifest Huntington's disease.

Authors:
Martin Gorges Hans-Peter Müller Isabella Maria Sophie Mayer Gesa Sophie Grupe Thomas Kammer Georg Grön Jan Kassubek G Bernhard Landwehrmeyer Robert Christian Wolf Michael Orth

Sci Rep 2017 03 7;7:43841. Epub 2017 Mar 7.

Department of Neurology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1038/srep43841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339687PMC
March 2017

Validation of a prognostic index for Huntington's disease.

Authors:
Jeffrey D Long Douglas R Langbehn Sarah J Tabrizi Bernhard G Landwehrmeyer Jane S Paulsen John Warner Cristina Sampaio

Mov Disord 2017 02 28;32(2):256-263. Epub 2016 Nov 28.

CHDI Management/CHDI Foundation, Princeton, New Jersey, USA.

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http://dx.doi.org/10.1002/mds.26838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318276PMC
February 2017

A randomized exploratory phase 2 study in patients with chemotherapy-related peripheral neuropathy evaluating whole-body vibration training as adjunct to an integrated program including massage, passive mobilization and physical exercises.

Authors:
Stefan S Schönsteiner Heidi Bauder Mißbach Axel Benner Silja Mack Thomas Hamel Michael Orth Bernhard Landwehrmeyer Sigurd D Süßmuth Carolin Geitner Regine Mayer-Steinacker Anneliese Riester Andrea Prokein Elfriede Erhardt Jelena Kunecki Anna M Eisenschink Rainer Rawer Hartmut Döhner Elisabeth Kirchner Richard F Schlenk

Exp Hematol Oncol 2017 7;6. Epub 2017 Feb 7.

Department of Internal Medicine III, University Hospital Ulm, Albert Einstein Allee 23, 89081 Ulm, Germany.

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http://dx.doi.org/10.1186/s40164-017-0065-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297221PMC
February 2017

Eighth International Chorea-Acanthocytosis Symposium: Summary of Workshop Discussion and Action Points.

Authors:
Samuel S Pappas Juan Bonifacino Adrian Danek William T Dauer Mithu De Lucia De Franceschi Gilbert DiPaolo Robert Fuller Volker Haucke Andreas Hermann Benoit Kornmann Bernhard Landwehrmeyer Johannes Levin Aaron M Neiman Dobrila D Rudnicki Ody Sibon Antonio Velayos-Baeza Jan J Vonk Ruth H Walker Lois S Weisman Roger L Albin

Tremor Other Hyperkinet Mov (N Y) 2017 15;7:428. Epub 2017 Feb 15.

Department of Neurology, University of Michigan, Ann Arbor, MI, USA; Neurology Service, VAAAHS, University of Michigan, Ann Arbor, MI, USA; Udall Centre, University of Michigan, Ann Arbor, MI, USA; GRECC, VAAAHS, University of Michigan, Ann Arbor, MI, USA,; Michigan Alzheimer's Disease Center, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.7916/D8XD127WDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313633PMC
February 2017

Natural variation in sensory-motor white matter organization influences manifestations of Huntington's disease.

Authors:
Michael Orth Sarah Gregory Rachael I Scahill Isabella Sm Mayer Lora Minkova Stefan Klöppel Kiran K Seunarine Lara Boyd Beth Borowsky Ralf Reilmann G Bernhard Landwehrmeyer Blair R Leavitt Raymund Ac Roos Alexandra Durr Geraint Rees John C Rothwell Douglas Langbehn Sarah J Tabrizi

Hum Brain Mapp 2016 12 1;37(12):4615-4628. Epub 2016 Aug 1.

Department of Neurodegenerative Disease, University College London, Institute of Neurology, Queen Square, London, United Kingdom.

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http://dx.doi.org/10.1002/hbm.23332DOI Listing
December 2016

The neuropsychology of first impressions: Evidence from Huntington's disease.

Authors:
Reiner Sprengelmeyer Andrew W Young Eva-Maria Baldas Iris Ratheiser Clare A M Sutherland Hans-Peter Müller Georg Grön Sigurd D Süssmuth G Bernhard Landwehrmeyer Michael Orth

Cortex 2016 12 21;85:100-115. Epub 2016 Oct 21.

Department of Neurology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1016/j.cortex.2016.10.006DOI Listing
December 2016

Longitudinal Diffusion Tensor Imaging Shows Progressive Changes in White Matter in Huntington's Disease.

Authors:
Sarah Gregory James H Cole Ruth E Farmer Elin M Rees Raymund A C Roos Reiner Sprengelmeyer Alexandra Durr Bernhard Landwehrmeyer Hui Zhang Rachael I Scahill Sarah J Tabrizi Chris Frost Nicola Z Hobbs

J Huntingtons Dis 2015 ;4(4):333-46

UCL Institute of Neurology, University College London, UK.

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http://dx.doi.org/10.3233/JHD-150173DOI Listing
October 2016

Atrophy and structural covariance of the cholinergic basal forebrain in primary progressive aphasia.

Authors:
Stefan Teipel Theresa Raiser Lina Riedl Isabelle Riederer Matthias L Schroeter Sandrine Bisenius Anja Schneider Johannes Kornhuber Klaus Fliessbach Annika Spottke Michel J Grothe Johannes Prudlo Jan Kassubek Albert Ludolph Bernhard Landwehrmeyer Sarah Straub Markus Otto Adrian Danek

Cortex 2016 10 16;83:124-35. Epub 2016 Jul 16.

Department of Neurology, University of Munich, Munich, Germany.

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http://dx.doi.org/10.1016/j.cortex.2016.07.004DOI Listing
October 2016

Corrigendum to "Neuropsychiatric symptoms are very common in premanifest and early stage Huntington's disease" [Parkinsonism Relat. Disord. 25C (2016) 58-64].

Authors:
Saul Martinez-Horta Jesus Perez-Perez Erik van Duijn Ramon Fernandez-Bobadilla Mar Carceller Javier Pagonabarraga Berta Pascual-Sedano Antonia Campolongo Jesus Ruiz-Idiago Frederic Sampedro G Bernhard Landwehrmeyer Jaime Kulisevsky

Parkinsonism Relat Disord 2016 10 25;31:161. Epub 2016 Aug 25.

Department of Neurology, Movement Disorders Unit, Hospital de la Santa Creu i Sant Pau, Universitat Aut_onoma de Barcelona, Barcelona, Spain; Sant Pau Institute of Biomedical Research (IIB-Sant Pau), Barcelona, Spain; Centro Investigaci_on Biomedica en Red-Enfermedades Neurodegenerativas (CIBERNED), Spain; Universitat Oberta de Catalunya (UOC), Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2016.08.011DOI Listing
October 2016

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis.

Authors:
Wouter van Rheenen Aleksey Shatunov Annelot M Dekker Russell L McLaughlin Frank P Diekstra Sara L Pulit Rick A A van der Spek Urmo Võsa Simone de Jong Matthew R Robinson Jian Yang Isabella Fogh Perry Tc van Doormaal Gijs H P Tazelaar Max Koppers Anna M Blokhuis William Sproviero Ashley R Jones Kevin P Kenna Kristel R van Eijk Oliver Harschnitz Raymond D Schellevis William J Brands Jelena Medic Androniki Menelaou Alice Vajda Nicola Ticozzi Kuang Lin Boris Rogelj Katarina Vrabec Metka Ravnik-Glavač Blaž Koritnik Janez Zidar Lea Leonardis Leja Dolenc Grošelj Stéphanie Millecamps François Salachas Vincent Meininger Mamede de Carvalho Susana Pinto Jesus S Mora Ricardo Rojas-García Meraida Polak Siddharthan Chandran Shuna Colville Robert Swingler Karen E Morrison Pamela J Shaw John Hardy Richard W Orrell Alan Pittman Katie Sidle Pietro Fratta Andrea Malaspina Simon Topp Susanne Petri Susanne Abdulla Carsten Drepper Michael Sendtner Thomas Meyer Roel A Ophoff Kim A Staats Martina Wiedau-Pazos Catherine Lomen-Hoerth Vivianna M Van Deerlin John Q Trojanowski Lauren Elman Leo McCluskey A Nazli Basak Ceren Tunca Hamid Hamzeiy Yesim Parman Thomas Meitinger Peter Lichtner Milena Radivojkov-Blagojevic Christian R Andres Cindy Maurel Gilbert Bensimon Bernhard Landwehrmeyer Alexis Brice Christine A M Payan Safaa Saker-Delye Alexandra Dürr Nicholas W Wood Lukas Tittmann Wolfgang Lieb Andre Franke Marcella Rietschel Sven Cichon Markus M Nöthen Philippe Amouyel Christophe Tzourio Jean-François Dartigues Andre G Uitterlinden Fernando Rivadeneira Karol Estrada Albert Hofman Charles Curtis Hylke M Blauw Anneke J van der Kooi Marianne de Visser An Goris Markus Weber Christopher E Shaw Bradley N Smith Orietta Pansarasa Cristina Cereda Roberto Del Bo Giacomo P Comi Sandra D'Alfonso Cinzia Bertolin Gianni Sorarù Letizia Mazzini Viviana Pensato Cinzia Gellera Cinzia Tiloca Antonia Ratti Andrea Calvo Cristina Moglia Maura Brunetti Simona Arcuti Rosa Capozzo Chiara Zecca Christian Lunetta Silvana Penco Nilo Riva Alessandro Padovani Massimiliano Filosto Bernard Muller Robbert Jan Stuit Ian Blair Katharine Zhang Emily P McCann Jennifer A Fifita Garth A Nicholson Dominic B Rowe Roger Pamphlett Matthew C Kiernan Julian Grosskreutz Otto W Witte Thomas Ringer Tino Prell Beatrice Stubendorff Ingo Kurth Christian A Hübner P Nigel Leigh Federico Casale Adriano Chio Ettore Beghi Elisabetta Pupillo Rosanna Tortelli Giancarlo Logroscino John Powell Albert C Ludolph Jochen H Weishaupt Wim Robberecht Philip Van Damme Lude Franke Tune H Pers Robert H Brown Jonathan D Glass John E Landers Orla Hardiman Peter M Andersen Philippe Corcia Patrick Vourc'h Vincenzo Silani Naomi R Wray Peter M Visscher Paul I W de Bakker Michael A van Es R Jeroen Pasterkamp Cathryn M Lewis Gerome Breen Ammar Al-Chalabi Leonard H van den Berg Jan H Veldink

Nat Genet 2016 09 25;48(9):1043-8. Epub 2016 Jul 25.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/ng.3622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556360PMC
September 2016

Neuropsychiatric symptoms are very common in premanifest and early stage Huntington's Disease.

Authors:
Saul Martinez-Horta Jesus Perez-Perez Erik van Duijn Ramon Fernandez-Bobadilla Mar Carceller Javier Pagonabarraga Berta Pascual-Sedano Antonia Campolongo Jesus Ruiz-Idiago Frederic Sampedro G Bernhard Landwehrmeyer Jaime Kulisevsky

Parkinsonism Relat Disord 2016 Apr 11;25:58-64. Epub 2016 Feb 11.

Department of Neurology, Movement Disorders Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Sant Pau Institute of Biomedical Research (IIB-Sant Pau), Barcelona, Spain; Centro Investigación Biomedica en Red-Enfermedades Neurodegenerativas (CIBERNED), Spain; Universitat Oberta de Catalunya (UOC), Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2016.02.008DOI Listing
April 2016

Motor network structure and function are associated with motor performance in Huntington's disease.

Authors:
Hans-Peter Müller Martin Gorges Georg Grön Jan Kassubek G Bernhard Landwehrmeyer Sigurd D Süßmuth Robert Christian Wolf Michael Orth

J Neurol 2016 Mar 13;263(3):539-49. Epub 2016 Jan 13.

Department of Neurology, University of Ulm, Oberer Eselsberg 45/1, 89081, Ulm, Germany.

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http://dx.doi.org/10.1007/s00415-015-8014-yDOI Listing
March 2016

Abnormal cerebellar volume and corticocerebellar dysfunction in early manifest Huntington's disease.

Authors:
Robert Christian Wolf Philipp Arthur Thomann Fabio Sambataro Nadine Donata Wolf Nenad Vasic G Bernhard Landwehrmeyer Sigurd Dietrich Süßmuth Michael Orth

J Neurol 2015 28;262(4):859-69. Epub 2015 Jan 28.

Department of Psychiatry, Psychotherapy and Psychosomatics, Saarland University, Kirrberger Str. 1, 66421, Homburg, Germany,

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http://dx.doi.org/10.1007/s00415-015-7642-6DOI Listing
January 2016

Medication Use in Early-HD Participants in Track-HD: an Investigation of its Effects on Clinical Performance.

Authors:
Ruth Keogh Chris Frost Gail Owen Rhian M Daniel Doug R Langbehn Blair Leavitt Alexandra Durr Raymund A C Roos G Bernhard Landwehrmeyer Ralf Reilmann Beth Borowsky Julie Stout David Craufurd Sarah J Tabrizi

PLoS Curr 2016 Jan 11;8. Epub 2016 Jan 11.

Neurodegenerative Disease, UCL Institute of Neurology, London, UK.

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http://dx.doi.org/10.1371/currents.hd.8060298fac1801b01ccea6acc00f97cbDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718719PMC
January 2016

Short-interval observational data to inform clinical trial design in Huntington's disease.

Authors:
Nicola Z Hobbs Ruth E Farmer Elin M Rees James H Cole Salman Haider Ian B Malone Reiner Sprengelmeyer Hans Johnson Hans-Peter Mueller Sigurd D Sussmuth Raymund A C Roos Alexandra Durr Chris Frost Rachael I Scahill Bernhard Landwehrmeyer Sarah J Tabrizi

J Neurol Neurosurg Psychiatry 2015 Dec 10;86(12):1291-8. Epub 2015 Feb 10.

Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.

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http://dx.doi.org/10.1136/jnnp-2014-309768DOI Listing
December 2015

Selective vulnerability of Rich Club brain regions is an organizational principle of structural connectivity loss in Huntington's disease.

Authors:
Peter McColgan Kiran K Seunarine Adeel Razi James H Cole Sarah Gregory Alexandra Durr Raymund A C Roos Julie C Stout Bernhard Landwehrmeyer Rachael I Scahill Chris A Clark Geraint Rees Sarah J Tabrizi

Brain 2015 Nov 17;138(Pt 11):3327-44. Epub 2015 Sep 17.

3 Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, WC1N 3BG, UK.

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http://brain.oxfordjournals.org/content/brain/early/2015/09/
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http://www.brain.oxfordjournals.org/lookup/doi/10.1093/brain
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http://dx.doi.org/10.1093/brain/awv259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620513PMC
November 2015

Compensation in Preclinical Huntington's Disease: Evidence From the Track-On HD Study.

Authors:
Stefan Klöppel Sarah Gregory Elisa Scheller Lora Minkova Adeel Razi Alexandra Durr Raymund A C Roos Blair R Leavitt Marina Papoutsi G Bernhard Landwehrmeyer Ralf Reilmann Beth Borowsky Hans Johnson James A Mills Gail Owen Julie Stout Rachael I Scahill Jeffrey D Long Geraint Rees Sarah J Tabrizi

EBioMedicine 2015 Oct 4;2(10):1420-9. Epub 2015 Aug 4.

Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.

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http://dx.doi.org/10.1016/j.ebiom.2015.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634199PMC
October 2015

Ethyl-eicosapentaenoic acid treatment in Huntington's disease: A placebo-controlled clinical trial.

Authors:
Joaquim J Ferreira Anne Rosser David Craufurd Ferdinando Squitieri Nicholas Mallard Bernhard Landwehrmeyer

Mov Disord 2015 Sep 14;30(10):1426-9. Epub 2015 Jul 14.

Universitätsklinik Ulm, Ulm, Germany.

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http://dx.doi.org/10.1002/mds.26308DOI Listing
September 2015

Prodromal Huntington disease as a model for functional compensation of early neurodegeneration.

Authors:
Kathrin Malejko Patrick Weydt Sigurd D Süßmuth Georg Grön Bernhard G Landwehrmeyer Birgit Abler

PLoS One 2014 26;9(12):e114569. Epub 2014 Dec 26.

Department of Psychiatry, Ulm University, Leimgrubenweg 12-14, 89522, Ulm, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114569PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277279PMC
August 2015

Two-point magnitude MRI for rapid mapping of brown adipose tissue and its application to the R6/2 mouse model of Huntington disease.

Authors:
Katrin S Lindenberg Patrick Weydt Hans-Peter Müller Axel Bornstedt Albert C Ludolph G Bernhard Landwehrmeyer Wolfgang Rottbauer Jan Kassubek Volker Rasche

PLoS One 2014 21;9(8):e105556. Epub 2014 Aug 21.

Department of Internal Medicine II, Ulm University, Ulm, Germany; Core Facility Small Animal Imaging, Ulm University, Ulm, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105556PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140810PMC
May 2015

An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease.

Authors:
Sigurd D Süssmuth Salman Haider G Bernhard Landwehrmeyer Ruth Farmer Chris Frost Giovanna Tripepi Claus A Andersen Marco Di Bacco Claudia Lamanna Enrica Diodato Luisa Massai Daniela Diamanti Elisa Mori Letizia Magnoni Jens Dreyhaupt Karin Schiefele David Craufurd Carsten Saft Monika Rudzinska Danuta Ryglewicz Michael Orth Sebastian Brzozy Anna Baran Giuseppe Pollio Ralph Andre Sarah J Tabrizi Borje Darpo Goran Westerberg

Br J Clin Pharmacol 2015 Mar;79(3):465-76

Department of Neurology, Ulm University Hospital, Ulm, Germany.

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http://dx.doi.org/10.1111/bcp.12512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345957PMC
March 2015

Update on Huntington's disease: advances in care and emerging therapeutic options.

Authors:
Daniel Zielonka Michal Mielcarek G Bernhard Landwehrmeyer

Parkinsonism Relat Disord 2015 Mar 19;21(3):169-78. Epub 2014 Dec 19.

Department of Neurology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1016/j.parkreldis.2014.12.013DOI Listing
March 2015

Neuropsychiatric symptoms in a European Huntington's disease cohort (REGISTRY).

Authors:
Erik van Duijn David Craufurd Anna A M Hubers Erik J Giltay Raphael Bonelli Hugh Rickards Karen E Anderson Marleen R van Walsem Rose C van der Mast Michael Orth G Bernhard Landwehrmeyer

J Neurol Neurosurg Psychiatry 2014 Dec 14;85(12):1411-8. Epub 2014 May 14.

Department of Neurology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1136/jnnp-2013-307343DOI Listing
December 2014

Cerebellar abnormalities in Huntington's disease: a role in motor and psychiatric impairment?

Authors:
Elin M Rees Ruth Farmer James H Cole Salman Haider Alexandra Durr Bernhard Landwehrmeyer Rachael I Scahill Sarah J Tabrizi Nicola Z Hobbs

Mov Disord 2014 Nov 13;29(13):1648-54. Epub 2014 Aug 13.

University College London, Institute of Neurology, Queen Square, London, UK.

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http://dx.doi.org/10.1002/mds.25984DOI Listing
November 2014

Corpus callosal atrophy in premanifest and early Huntington's disease.

Authors:
Helen E Crawford Nicola Z Hobbs Ruth Keogh Douglas R Langbehn Chris Frost Hans Johnson Bernhard Landwehrmeyer Ralf Reilmann David Craufurd Julie C Stout Alexandra Durr Blair R Leavitt Raymund A C Roos Sarah J Tabrizi Rachael I Scahill

J Huntingtons Dis 2013 ;2(4):517-26

UCL Institute of Neurology, University College London, UK.

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http://dx.doi.org/10.3233/JHD-130077DOI Listing
September 2014

Longitudinal task-negative network analyses in preclinical Huntington's disease.

Authors:
Robert Christian Wolf Fabio Sambataro Nenad Vasic Nadine Donata Wolf Philipp Arthur Thomann G Bernhard Landwehrmeyer Michael Orth

Eur Arch Psychiatry Clin Neurosci 2014 Sep 27;264(6):493-505. Epub 2013 Sep 27.

Center for Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Voßstraße 4, 69115, Heidelberg, Germany,

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http://dx.doi.org/10.1007/s00406-013-0447-7DOI Listing
September 2014

Impact of the control for corrupted diffusion tensor imaging data in comparisons at the group level: an application in Huntington disease.

Authors:
Hans-Peter Müller Jan Kassubek Georg Grön Reiner Sprengelmeyer Albert C Ludolph Stefan Klöppel Nicola Z Hobbs Raymund A C Roos Alexandra Duerr Sarah J Tabrizi Michael Orth Sigurd D Süssmuth G Bernhard Landwehrmeyer

Biomed Eng Online 2014 Sep 1;13:128. Epub 2014 Sep 1.

Department of Neurology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1186/1475-925X-13-128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162922PMC
September 2014

Visual system integrity and cognition in early Huntington's disease.

Authors:
Robert C Wolf Fabio Sambataro Nenad Vasic Eva-Maria Baldas Iris Ratheiser Georg Bernhard Landwehrmeyer Malte S Depping Philipp A Thomann Reiner Sprengelmeyer Sigurd D Süssmuth Michael Orth

Eur J Neurosci 2014 Jul 3;40(2):2417-26. Epub 2014 Apr 3.

Department of General Psychiatry, Center for Psychosocial Medicine, University of Heidelberg, Voßstraße 4, Heidelberg, 69115, Germany.

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http://dx.doi.org/10.1111/ejn.12575DOI Listing
July 2014

Brain structure in preclinical Huntington's disease: a multi-method approach.

Authors:
Robert Christian Wolf Philipp Arthur Thomann Anne Kerstin Thomann Nenad Vasic Nadine Donata Wolf G Bernhard Landwehrmeyer Michael Orth

Neurodegener Dis 2013 17;12(1):13-22. Epub 2012 Aug 17.

Center of Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1159/000338635DOI Listing
January 2014

A single nucleotide polymorphism in the coding region of PGC-1α is a male-specific modifier of Huntington disease age-at-onset in a large European cohort.

Authors:
Patrick Weydt Selma M Soyal G Bernhard Landwehrmeyer Wolfgang Patsch

BMC Neurol 2014 Jan 2;14. Epub 2014 Jan 2.

Neurology, Ulm University, 89081 Ulm, Germany.

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http://dx.doi.org/10.1186/1471-2377-14-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880172PMC
January 2014

Evaluation of multi-modal, multi-site neuroimaging measures in Huntington's disease: Baseline results from the PADDINGTON study.

Authors:
Nicola Z Hobbs James H Cole Ruth E Farmer Elin M Rees Helen E Crawford Ian B Malone Raymund A C Roos Reiner Sprengelmeyer Alexandra Durr Bernhard Landwehrmeyer Rachael I Scahill Sarah J Tabrizi Chris Frost

Neuroimage Clin 2012 9;2:204-11. Epub 2012 Dec 9.

UCL Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.

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http://dx.doi.org/10.1016/j.nicl.2012.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777685PMC
November 2013

Evaluating multicenter DTI data in Huntington's disease on site specific effects: An ex post facto approach.

Authors:
Hans-Peter Müller Georg Grön Reiner Sprengelmeyer Jan Kassubek Albert C Ludolph Nicola Hobbs James Cole Raymund A C Roos Alexandra Duerr Sarah J Tabrizi G Bernhard Landwehrmeyer Sigurd D Süssmuth

Neuroimage Clin 2013 3;2:161-7. Epub 2013 Jan 3.

Department of Neurology, University of Ulm, Germany.

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http://dx.doi.org/10.1016/j.nicl.2012.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777841PMC
November 2013

Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells.

Authors:
Luisa Massai Lara Petricca Letizia Magnoni Luca Rovetini Salman Haider Ralph Andre Sarah J Tabrizi Sigurd D Süssmuth Bernhard G Landwehrmeyer Andrea Caricasole Giuseppe Pollio Simonetta Bernocco

BMC Biochem 2013 Nov 25;14:34. Epub 2013 Nov 25.

Pharmacology Department, Siena Biotech SpA, Strada del Petriccio e Belriguardo, 35, 53100 Siena, Italy.

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http://dx.doi.org/10.1186/1471-2091-14-34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221641PMC
November 2013

The personal experience of parenting a child with juvenile Huntington's disease: perceptions across Europe.

Authors:
Virginia Eatough Helen Santini Christine Eiser Marie-Louise Goller Wioletta Krysa 'Annunziata' de Nicola Matteo Paduanello Martina Petrollini Maria Rakowicz Ferdinando Squitieri Aad Tibben Katie Lee Weille Bernhard Landwehrmeyer Oliver Quarrell Jonathan A Smith

Eur J Hum Genet 2013 Oct 27;21(10):1042-8. Epub 2013 Feb 27.

Department of Psychological Sciences, Birkbeck, University of London, London, UK.

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http://dx.doi.org/10.1038/ejhg.2013.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778352PMC
October 2013

Association between caffeine intake and age at onset in Huntington's disease.

Authors:
Clémence Simonin Cécile Duru Julia Salleron Pascale Hincker Perrine Charles Arnaud Delval Katia Youssov Sylvie Burnouf Jean-Philippe Azulay Christophe Verny Clarisse Scherer Christine Tranchant Cyril Goizet Sabrina Debruxelles Luc Defebvre Bernard Sablonnière Monique Romon-Rousseaux Luc Buée Alain Destée Olivier Godefroy Alexandra Dürr Bernhard Landwehrmeyer Anne-Catherine Bachoud-Levi Florence Richard David Blum Pierre Krystkowiak

Neurobiol Dis 2013 Oct 31;58:179-82. Epub 2013 May 31.

Department of Neurology and Movement Disorders, Roger Salengro University Hospital, Lille, France.

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http://dx.doi.org/10.1016/j.nbd.2013.05.013DOI Listing
October 2013

Longitudinal task-negative network analyses in preclinical Huntington's disease.

Authors:
Robert Christian Wolf Fabio Sambataro Nenad Vasic Nadine Donata Wolf Philipp Arthur Thomann G Bernhard Landwehrmeyer Michael Orth

Eur Arch Psychiatry Clin Neurosci 2014 Sep 27;264(6):493-505. Epub 2013 Sep 27.

Center for Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Voßstraße 4, 69115, Heidelberg, Germany,

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http://dx.doi.org/10.1007/s00406-013-0447-7DOI Listing
September 2014

Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data.

Authors:
Sarah J Tabrizi Rachael I Scahill Gail Owen Alexandra Durr Blair R Leavitt Raymund A Roos Beth Borowsky Bernhard Landwehrmeyer Chris Frost Hans Johnson David Craufurd Ralf Reilmann Julie C Stout Douglas R Langbehn

Lancet Neurol 2013 Jul 9;12(7):637-49. Epub 2013 May 9.

UCL Institute of Neurology, University College London, London, UK.

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http://dx.doi.org/10.1016/S1474-4422(13)70088-7DOI Listing
July 2013

One-year safety and tolerability profile of pridopidine in patients with Huntington disease.

Authors:
Ferdinando Squitieri Bernhard Landwehrmeyer Ralf Reilmann Anne Rosser Justo Garcia de Yebenes Allan Prang Jelena Ivkovic Jeremy Bright Asa Rembratt

Neurology 2013 Mar 27;80(12):1086-94. Epub 2013 Feb 27.

Centre for Neurogenetics and Rare Diseases, IRCCS Neuromed, Pozzilli, Italy.

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http://dx.doi.org/10.1212/WNL.0b013e3182886965DOI Listing
March 2013

The influence of gender on phenotype and disease progression in patients with Huntington's disease.

Authors:
Daniel Zielonka Johan Marinus Raymund A C Roos Giuseppe De Michele Stefano Di Donato Hein Putter Jerzy Marcinkowski Ferdinando Squitieri Anna Rita Bentivoglio G Bernhard Landwehrmeyer

Parkinsonism Relat Disord 2013 Feb 25;19(2):192-7. Epub 2012 Oct 25.

Poznan University of Medical Sciences, Department of Social Medicine, Rokietnicka Str., No. 5 C, 60-806 Poznan, Poland.

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http://dx.doi.org/10.1016/j.parkreldis.2012.09.012DOI Listing
February 2013

Comparative analyses of Purkinje cell gene expression profiles reveal shared molecular abnormalities in models of different polyglutamine diseases.

Authors:
Bernd Friedrich Philipp Euler Ruhtraut Ziegler Alexandre Kuhn Bernhard G Landwehrmeyer Ruth Luthi-Carter Cornelius Weiller Sabine Hellwig Birgit Zucker

Brain Res 2012 Oct 17;1481:37-48. Epub 2012 Aug 17.

Department of Neurology, University Hospital Freiburg, Germany.

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http://dx.doi.org/10.1016/j.brainres.2012.08.005DOI Listing
October 2012

Default-mode network changes in preclinical Huntington's disease.

Authors:
Robert Christian Wolf Fabio Sambataro Nenad Vasic Nadine Donata Wolf Philipp Arthur Thomann Carsten Saft G Bernhard Landwehrmeyer Michael Orth

Exp Neurol 2012 Sep 25;237(1):191-8. Epub 2012 Jun 25.

Center for Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.expneurol.2012.06.014DOI Listing
September 2012

Brain activation and functional connectivity in premanifest Huntington's disease during states of intrinsic and phasic alertness.

Authors:
Robert Christian Wolf Georg Grön Fabio Sambataro Nenad Vasic Nadine Donata Wolf Philipp Arthur Thomann Carsten Saft G Bernhard Landwehrmeyer Michael Orth

Hum Brain Mapp 2012 Sep 25;33(9):2161-73. Epub 2011 Aug 25.

Center of Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Germany.

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http://dx.doi.org/10.1002/hbm.21348DOI Listing
September 2012

A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset.

Authors:
Selma M Soyal Thomas K Felder Simon Auer Penelope Hahne Hannes Oberkofler Anke Witting Markus Paulmichl G Bernhard Landwehrmeyer Patrick Weydt Wolfgang Patsch

Hum Mol Genet 2012 Aug 15;21(15):3461-73. Epub 2012 May 15.

Department of Laboratory Medicine, Paracelsus Medical University, Strubergasse 21, 5020 Salzburg, Austria.

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http://dx.doi.org/10.1093/hmg/dds177DOI Listing
August 2012

TAA repeat variation in the GRIK2 gene does not influence age at onset in Huntington's disease.

Authors:
Ji-Hyun Lee Jong-Min Lee Eliana Marisa Ramos Tammy Gillis Jayalakshmi S Mysore Shotaro Kishikawa Tiffany Hadzi Audrey E Hendricks Michael R Hayden Patrick J Morrison Martha Nance Christopher A Ross Russell L Margolis Ferdinando Squitieri Cinzia Gellera Estrella Gomez-Tortosa Carmen Ayuso Oksana Suchowersky Ronald J Trent Elizabeth McCusker Andrea Novelletto Marina Frontali Randi Jones Tetsuo Ashizawa Samuel Frank Marie-Helene Saint-Hilaire Steven M Hersch Herminia D Rosas Diane Lucente Madaline B Harrison Andrea Zanko Ruth K Abramson Karen Marder Jorge Sequeiros G Bernhard Landwehrmeyer Ira Shoulson Richard H Myers Marcy E MacDonald James F Gusella

Biochem Biophys Res Commun 2012 Aug 3;424(3):404-8. Epub 2012 Jul 3.

Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.bbrc.2012.06.120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752397PMC
August 2012

Quantifying change in individual subjects affected by frontotemporal lobar degeneration using automated longitudinal MRI volumetry.

Authors:
Lars Frings Irina Mader Bernhard G Landwehrmeyer Cornelius Weiller Michael Hüll Hans-Jürgen Huppertz

Hum Brain Mapp 2012 Jul 26;33(7):1526-35. Epub 2011 May 26.

Department of Psychiatry and Psychotherapy, Center of Geriatrics and Gerontology Freiburg, Freiburg Brain Imaging, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1002/hbm.21304DOI Listing
July 2012

Stability effects on results of diffusion tensor imaging analysis by reduction of the number of gradient directions due to motion artifacts: an application to presymptomatic Huntington's disease.

Authors:
Hans-Peter Müller Sigurd D Süssmuth G Bernhard Landwehrmeyer Albert Ludolph Sarah J Tabrizi Stefan Kloppel Jan Kassubek

PLoS Curr 2011 Dec 12;3:RRN1292. Epub 2011 Dec 12.

Dept. of Neurology, University of Ulm, Ulm, Germany; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK and Freiburg Brain Imaging, Department of Psychiatry and Psychotherapy. University of Freiburg.

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http://dx.doi.org/10.1371/currents.RRN1292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269342PMC
December 2011

Current Pharmacological Management in Juvenile Huntington's Disease.

Authors:
Lisa Robertson Helen Santini Kirsty L O'Donovan Ferdinando Squitieri Roger A Barker Maria Rakowicz G Bernhard Landwehrmeyer Oliver Quarrell

PLoS Curr 2012 Feb 15;4:RRN1304. Epub 2012 Feb 15.

Department of Clinical Genetics, Sheffield Children's Hospital, Sheffield UK S10 2TH; Neurogenetics and Rare Diseases Centre, IRCCS Neuromed, Pozzilli (IS), Italy.; University of Cambridge; Department of Clinical Neurophysiology, Institute of Psychiatry and Naurology, Warsaw, Poland and Dept. of Neurology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1371/currents.RRN1304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283037PMC
February 2012

Discrepancies in reporting the CAG repeat lengths for Huntington's disease.

Authors:
Oliver W Quarrell Olivia Handley Kirsty O'Donovan Christine Dumoulin Maria Ramos-Arroyo Ida Biunno Peter Bauer Margaret Kline G Bernhard Landwehrmeyer

Eur J Hum Genet 2012 Jan 3;20(1):20-6. Epub 2011 Aug 3.

Department of Clinical Genetics, Sheffield Children's Hospital, Sheffield, UK.

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http://dx.doi.org/10.1038/ejhg.2011.136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234505PMC
January 2012

Rate of change in early Huntington's disease: a clinicometric analysis.

Authors:
Christina Meyer Bernhard Landwehrmeyer Carsten Schwenke Adam Doble Michael Orth Albert C Ludolph

Mov Disord 2012 Jan 17;27(1):118-24. Epub 2011 Nov 17.

Department of Neurology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1002/mds.23847DOI Listing
January 2012

Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data.

Authors:
Sarah J Tabrizi Ralf Reilmann Raymund A C Roos Alexandra Durr Blair Leavitt Gail Owen Rebecca Jones Hans Johnson David Craufurd Stephen L Hicks Christopher Kennard Bernhard Landwehrmeyer Julie C Stout Beth Borowsky Rachael I Scahill Chris Frost Douglas R Langbehn

Lancet Neurol 2012 Jan 2;11(1):42-53. Epub 2011 Dec 2.

UCL Institute of Neurology, University College London, Queen Square, London, UK.

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http://dx.doi.org/10.1016/S1474-4422(11)70263-0DOI Listing
January 2012

Huntington's disease: new aspects on phenotype and genotype.

Authors:
Huifang Shang Adrian Danek Bernhard Landwehrmeyer Jean-Marc Burgunder

Parkinsonism Relat Disord 2012 Jan;18 Suppl 1:S107-9

Department of Neurology, West China Hospital, Sichuan University, Sichuan, PR China.

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http://dx.doi.org/10.1016/S1353-8020(11)70034-7DOI Listing
January 2012

Disease severity and progression in progressive supranuclear palsy and multiple system atrophy: validation of the NNIPPS--Parkinson Plus Scale.

Authors:
Christine A M Payan François Viallet Bernhard G Landwehrmeyer Anne-Marie Bonnet Michel Borg Franck Durif Lucette Lacomblez Frédéric Bloch Marc Verny Jacques Fermanian Yves Agid Albert C Ludolph Peter N Leigh Gilbert Bensimon

PLoS One 2011 4;6(8):e22293. Epub 2011 Aug 4.

Département de Pharmacologie Clinique, Hôpital de la Pitié-Salpêtrière, APHP, UPMC Pharmacologie, Paris 6, UMR 7211, Paris, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022293PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150329PMC
December 2011

Pridopidine for the treatment of motor function in patients with Huntington's disease (MermaiHD): a phase 3, randomised, double-blind, placebo-controlled trial.

Authors:
Justo Garcia de Yebenes Bernhard Landwehrmeyer Ferdinando Squitieri Ralf Reilmann Anne Rosser Roger A Barker Carsten Saft Markus K Magnet Alastair Sword Asa Rembratt Joakim Tedroff

Lancet Neurol 2011 Dec 7;10(12):1049-57. Epub 2011 Nov 7.

Department of Neurology, Hospital Ramón y Cajal, CIBERNED, Madrid, Spain.

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http://dx.doi.org/10.1016/S1474-4422(11)70233-2DOI Listing
December 2011

Stability effects on results of diffusion tensor imaging analysis by reduction of the number of gradient directions due to motion artifacts: an application to presymptomatic Huntington's disease.

Authors:
Hans-Peter Müller Sigurd D Süssmuth G Bernhard Landwehrmeyer Albert Ludolph Sarah J Tabrizi Stefan Kloppel Jan Kassubek

PLoS Curr 2011 Dec 12;3:RRN1292. Epub 2011 Dec 12.

Dept. of Neurology, University of Ulm, Ulm, Germany; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK and Freiburg Brain Imaging, Department of Psychiatry and Psychotherapy. University of Freiburg.

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http://dx.doi.org/10.1371/currents.RRN1292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269342PMC
December 2011

Longitudinal functional magnetic resonance imaging of cognition in preclinical Huntington's disease.

Authors:
Robert Christian Wolf Fabio Sambataro Nenad Vasic Nadine Donata Wolf Philipp Arthur Thomann G Bernhard Landwehrmeyer Michael Orth

Exp Neurol 2011 Oct 25;231(2):214-22. Epub 2011 Jun 25.

Center of Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.expneurol.2011.06.011DOI Listing
October 2011

NMDA receptor gene variations as modifiers in Huntington disease: a replication study.

Authors:
Carsten Saft Jörg T Epplen Stefan Wieczorek G Bernhard Landwehrmeyer Raymund A C Roos Justo Garcia de Yebenes Matthias Dose Sarah J Tabrizi David Craufurd Larissa Arning

PLoS Curr 2011 Oct 4;3:RRN1247. Epub 2011 Oct 4.

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http://discovery.ucl.ac.uk/1328045/1/1328045.pdf
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http://currents.plos.org/hd/article/nmda-receptor-gene-varia
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http://dx.doi.org/10.1371/currents.RRN1247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186947PMC
October 2011

Magnetic resonance perfusion imaging of resting-state cerebral blood flow in preclinical Huntington's disease.

Authors:
Robert C Wolf Georg Grön Fabio Sambataro Nenad Vasic Nadine D Wolf Philipp A Thomann Carsten Saft G Bernhard Landwehrmeyer Michael Orth

J Cereb Blood Flow Metab 2011 Sep 11;31(9):1908-18. Epub 2011 May 11.

Center of Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1038/jcbfm.2011.60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185882PMC
September 2011

What is the impact of education on Huntington's disease?

Authors:
Jose Luis López-Sendón Ana Royuela Patricia Trigo Michael Orth Herwig Lange Ralf Reilmann Jennifer Keylock Hugh Rickards Silvia Piacentini Ferdinando Squitieri Bernhard Landwehrmeyer Marie-Noelle Witjes-Ane Caroline K Jurgens Raymund A C Roos Victor Abraira Justo G de Yébenes

Mov Disord 2011 Jul 22;26(8):1489-95. Epub 2011 Mar 22.

Department of Neurology, Hospital Ramon y Cajal, Madrid, Spain.

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http://dx.doi.org/10.1002/mds.23385DOI Listing
July 2011

Caudate nucleus and insular activation during a pain suppression paradigm comparing thermal and electrical stimulation.

Authors:
Arthur P Wunderlich Roland Klug Gregor Stuber Bernhard Landwehrmeyer Frank Weber Wolfgang Freund

Open Neuroimag J 2011 18;5:1-8. Epub 2011 Jan 18.

Department of Diagnostic and Interventional Radiology, University Hospital, Ulm, Germany.

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http://benthamopen.com/ABSTRACT/TONIJ-5-1
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http://dx.doi.org/10.2174/1874440001105010001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106353PMC
July 2011

Summary of cerebrospinal fluid routine parameters in neurodegenerative diseases.

Authors:
Sarah Jesse Johannes Brettschneider Sigurd D Süssmuth Bernhard G Landwehrmeyer Christine A F von Arnim Albert C Ludolph Hayrettin Tumani Markus Otto

J Neurol 2011 Jun 25;258(6):1034-41. Epub 2010 Dec 25.

Department of Neurology, University of Ulm, Steinhövelstr. 1, 89075, Ulm, Germany.

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http://dx.doi.org/10.1007/s00415-010-5876-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101362PMC
June 2011

Assessment of motor symptoms and functional impact in prodromal and early huntington disease.

Authors:
Anthony L Vaccarino Terrence Sills Karen E Anderson Kevin Biglan Beth Borowsky Joseph Giuliano Mark Guttman Aileen K Ho Christopher Kennard Peter Kupchak G Bernhard Landwehrmeyer Andrew Michell Jane S Paulsen Ralf Reilmann Daniel P van Kammen John H Warner Ken Evans

PLoS Curr 2011 Jun 14;2:RRN1244. Epub 2011 Jun 14.

Research Methods, Ontario Cancer Biomarker Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1371/currents.RRN1244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114647PMC
June 2011

Factor analysis of behavioural symptoms in Huntington's disease.

Authors:
Hugh Rickards Jenny De Souza Marleen van Walsem Erik van Duijn Sheila A Simpson Ferdinando Squitieri Bernhard Landwehrmeyer

J Neurol Neurosurg Psychiatry 2011 Apr 14;82(4):411-2. Epub 2010 Apr 14.

Department of Neuropsychiatry, Birmingham and Solihull Mental Health Foundation Trust, Barberry Building, 25 Vincent Drive, Edgbaston, Birmingham B15 2FG, UK.

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http://dx.doi.org/10.1136/jnnp.2009.181149DOI Listing
April 2011

Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis.

Authors:
Sarah J Tabrizi Rachael I Scahill Alexandra Durr Raymund Ac Roos Blair R Leavitt Rebecca Jones G Bernhard Landwehrmeyer Nick C Fox Hans Johnson Stephen L Hicks Christopher Kennard David Craufurd Chris Frost Douglas R Langbehn Ralf Reilmann Julie C Stout

Lancet Neurol 2011 Jan 2;10(1):31-42. Epub 2010 Dec 2.

UCL Institute of Neurology, University College London, Department of Neurodegenerative Disease, Queen Square, London, UK.

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http://dx.doi.org/10.1016/S1474-4422(10)70276-3DOI Listing
January 2011

Utilisation of Healthcare and Associated Services in Huntington's disease: a data mining study.

Authors:
Monica Busse Dr Hasan Al-Madfai Joyce Kenkre G Bernhard Landwehrmeyer Annarita Bentivoglio Anne Rosser

PLoS Curr 2011 Jan 21;3:RRN1206. Epub 2011 Jan 21.

Department of Physiotherapy, Cardiff University, Ty Dewi Sant, Heath Park, Cardiff, UK; BGL Group; Health, Sport and Science, University of Glamorgan Pontypridd UK; Universitätsklinikum Ulm, Neurologie; Istitutodi Neurologia, Istituto di neurologia, Università Cattolica del Sacro Cuore, Roma, Italy and Cardiff University.

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http://dx.doi.org/10.1371/currents.RRN1206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034233PMC
January 2011

Observing Huntington's Disease: the European Huntington's Disease Network's REGISTRY.

Authors:
Michael Orth Olivia J Handley Carsten Schwenke Stephen B Dunnett David Craufurd Aileen K Ho Edward Wild Sarah J Tabrizi G Bernhard Landwehrmeyer

PLoS Curr 2010 Sep 28;2:RRN1184. Epub 2010 Sep 28.

Department of Neurology, University of Ulm, Ulm Germany

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http://dx.doi.org/10.1371/currents.RRN1184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947793PMC
September 2010

Differential pattern of brain-specific CSF proteins tau and amyloid-β in Parkinsonian syndromes.

Authors:
Sigurd D Süssmuth Ingo Uttner Bernhard Landwehrmeyer Elmar H Pinkhardt Johannes Brettschneider Axel Petzold Bernd Kramer Jörg B Schulz Christian Palm Markus Otto Albert C Ludolph Jan Kassubek Hayrettin Tumani

Mov Disord 2010 Jul;25(9):1284-8

Department of Neurology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1002/mds.22895DOI Listing
July 2010

Graded cutaneous electrical vs thermal stimulation in humans shows different insular and cingulate cortex activation.

Authors:
Wolfgang Freund Arthur P Wunderlich Gregor Stuber Bernhard Landwehrmeyer Roland Klug

Somatosens Mot Res 2010 ;27(1):15-27

Department of Diagnostic and Interventional Radiology, University Hospital, Ulm, Germany.

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http://www.tandfonline.com/doi/full/10.3109/0899022090351659
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http://dx.doi.org/10.3109/08990220903516593DOI Listing
May 2010

Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy.

Authors:
Ammar Al-Chalabi Alexandra Dürr Nicholas W Wood Michael H Parkinson Agnes Camuzat Jean-Sébastien Hulot Karen E Morrison Alan Renton Sigurd D Sussmuth Bernhard G Landwehrmeyer Albert Ludolph Yves Agid Alexis Brice P Nigel Leigh Gilbert Bensimon

PLoS One 2009 Sep 22;4(9):e7114. Epub 2009 Sep 22.

MRC Centre for Neurodegeneration Research, King's College London, Department of Clinical Neuroscience, Institute of Psychiatry, and NIHR Biomedical Research Centre, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007114PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743996PMC
September 2009