Publications by authors named "Bernhard Holzmann"

77Publications

TLR3 promotes hepatocyte proliferation after partial hepatectomy by stimulating uPA expression and the release of tissue-bound HGF.

FASEB J 2020 Jun 15. Epub 2020 Jun 15.

Department of Surgery, School of Medicine, Technical University of Munich, Munich, Germany.

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http://dx.doi.org/10.1096/fj.202000904RDOI Listing
June 2020

Migration of murine intestinal dendritic cell subsets upon intrinsic and extrinsic TLR3 stimulation.

Eur J Immunol 2020 Oct 27;50(10):1525-1536. Epub 2020 May 27.

Division of Biopharma, Institute for Health Technology, Technical University of Denmark (DTU), Kongens Lyngby, Denmark.

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http://dx.doi.org/10.1002/eji.201948497DOI Listing
October 2020

A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control.

J Hepatol 2020 May 15;72(5):960-975. Epub 2020 Jan 15.

Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany; Institute of Virology, Technical University of Munich and Helmholtz Zentrum München, Schneckenburgerstrasse 8, 81675 Munich, Germany; Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, Ismaningerstraße 22, 81675 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2019.12.019DOI Listing
May 2020

The neuropeptide receptor subunit RAMP1 constrains the innate immune response during acute pancreatitis in mice.

Pancreatology 2019 Jun 11;19(4):541-547. Epub 2019 May 11.

Technical University of Munich, School of Medicine, Klinikum Rechts der Isar, Department of Internal Medicine II, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.pan.2019.05.455DOI Listing
June 2019

A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain.

Nat Cell Biol 2019 06 13;21(6):731-742. Epub 2019 May 13.

Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1038/s41556-019-0324-3DOI Listing
June 2019

Cell-type specific MyD88 signaling is required for intestinal tumor initiation and progression to malignancy.

Oncoimmunology 2018 11;7(8):e1466770. Epub 2018 Jun 11.

Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Surgery; Ismaninger Str. 22, Munich, Germany.

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http://dx.doi.org/10.1080/2162402X.2018.1466770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136867PMC
June 2018

MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium.

PLoS Pathog 2017 May 16;13(5):e1006357. Epub 2017 May 16.

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.

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http://dx.doi.org/10.1371/journal.ppat.1006357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433783PMC
May 2017

Requirement of MyD88 signaling in keratinocytes for Langerhans cell migration and initiation of atopic dermatitis-like symptoms in mice.

Eur J Immunol 2016 Apr 18;46(4):981-92. Epub 2016 Jan 18.

Immunology and Environment, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1002/eji.201545710DOI Listing
April 2016

Procalcitonin ratio and on-demand relaparotomy for septic peritonitis: validation of the focus index (FI).

Surg Today 2016 May 27;46(5):603-12. Epub 2015 Jul 27.

Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Ismaningerstraße 22, 81675, Munich, Germany.

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http://dx.doi.org/10.1007/s00595-015-1226-zDOI Listing
May 2016

Neuroimmunological communication via CGRP promotes the development of a regulatory phenotype in TLR4-stimulated macrophages.

Eur J Immunol 2014 Dec 10;44(12):3708-16. Epub 2014 Nov 10.

Department of Surgery, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.1002/eji.201444553DOI Listing
December 2014

Dendritic cells coordinate innate immunity via MyD88 signaling to control Listeria monocytogenes infection.

Cell Rep 2014 Feb 13;6(4):698-708. Epub 2014 Feb 13.

Institute for Infection Immunology, TWINCORE, Center for Experimental and Clinical Infection Research, a Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Center for Infection Research (HZI), 30625 Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.01.023DOI Listing
February 2014

MyD88 signalling in myeloid cells is sufficient to prevent chronic mycobacterial infection.

Eur J Immunol 2014 May 13;44(5):1399-409. Epub 2014 Feb 13.

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a Joint Venture between the Medical School Hanover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hanover, Germany.

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http://dx.doi.org/10.1002/eji.201344039DOI Listing
May 2014

Antiinflammatory activities of CGRP modulating innate immune responses in health and disease.

Curr Protein Pept Sci 2013 Jun;14(4):268-74

Department of Surgery, Technische Universität München, Ismaninger Str. 22, 81675 München, Germany.

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http://dx.doi.org/10.2174/13892037113149990046DOI Listing
June 2013

Deficiency of the CGRP receptor component RAMP1 attenuates immunosuppression during the early phase of septic peritonitis.

Immunobiology 2012 Aug 4;217(8):761-7. Epub 2012 May 4.

Department of Surgery, Technical University Munich, Ismaninger Strasse 22, 81675 Munich, Germany.

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http://dx.doi.org/10.1016/j.imbio.2012.04.009DOI Listing
August 2012

Cutting edge: Divergent cell-specific functions of MyD88 for inflammatory responses and organ injury in septic peritonitis.

J Immunol 2012 Jun 14;188(12):5833-7. Epub 2012 May 14.

Chirurgische Klinik und Poliklinik, Technische Universität München, 81675 Munich, Germany.

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http://dx.doi.org/10.4049/jimmunol.1200038DOI Listing
June 2012

Mixed antagonist response and sepsis severity-dependent dysbalance of pro- and anti-inflammatory responses at the onset of postoperative sepsis.

Immunobiology 2012 Jun 3;217(6):616-21. Epub 2011 Nov 3.

Department of Surgery, Klinikum rechts der Isar, Technische Universitaet Muenchen, Ismaninger Strasse 22, 81675 Munich, Germany.

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http://dx.doi.org/10.1016/j.imbio.2011.10.019DOI Listing
June 2012

Modulation of immune responses by the neuropeptide CGRP.

Amino Acids 2013 Jul 24;45(1):1-7. Epub 2011 Nov 24.

Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675 München, Germany.

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http://dx.doi.org/10.1007/s00726-011-1161-2DOI Listing
July 2013

The candidate tumor suppressor SASH1 interacts with the actin cytoskeleton and stimulates cell-matrix adhesion.

Int J Biochem Cell Biol 2011 Nov 28;43(11):1630-40. Epub 2011 Jul 28.

Department of Surgery, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.

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http://dx.doi.org/10.1016/j.biocel.2011.07.012DOI Listing
November 2011

Improved host defense against septic peritonitis in mice lacking MyD88 and TRIF is linked to a normal interferon response.

J Leukoc Biol 2011 Sep 31;90(3):613-20. Epub 2011 May 31.

Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.1189/jlb.1110602DOI Listing
September 2011

Interleukin-10 and -12 predict chemotherapy-associated toxicity in esophageal adenocarcinoma.

J Thorac Oncol 2010 Nov;5(11):1849-54

Department of General, Visceral, and Children's Surgery, Heinrich Heine Universitaet Duesseldorf, Düsseldorf, Germany.

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http://dx.doi.org/10.1097/JTO.0b013e3181f19028DOI Listing
November 2010

LFA-1 activity state on dendritic cells regulates contact duration with T cells and promotes T-cell priming.

Blood 2010 Sep 8;116(11):1885-94. Epub 2010 Jun 8.

Department of Dermatology, Johannes-Gutenberg-Universität Mainz, Mainz, Germany.

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http://dx.doi.org/10.1182/blood-2009-05-224428DOI Listing
September 2010

TRIF signaling stimulates translation of TNF-alpha mRNA via prolonged activation of MK2.

J Immunol 2010 May 7;184(10):5842-8. Epub 2010 Apr 7.

Department of Surgery, Technical University of Munich, Munich, Germany.

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http://dx.doi.org/10.4049/jimmunol.0902456DOI Listing
May 2010

Differential expression of the chemokines GRO-2, GRO-3, and interleukin-8 in colon cancer and their impact on metastatic disease and survival.

Int J Colorectal Dis 2010 May 17;25(5):573-81. Epub 2010 Feb 17.

Department of Surgery, Klinikum rechts der Isar, Technische Universität München, München, Germany.

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http://dx.doi.org/10.1007/s00384-010-0901-1DOI Listing
May 2010

Intact LFA-1 deactivation promotes T-cell activation and rejection of cardiac allograft.

Int Immunol 2010 Jan 27;22(1):35-44. Epub 2009 Nov 27.

Department of Surgery, Technische Universität München, Ismaninger Strasse 22, 81675 Munich, Germany.

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http://dx.doi.org/10.1093/intimm/dxp111DOI Listing
January 2010

Procalcitonin ratio indicates successful surgical treatment of abdominal sepsis.

Surgery 2009 Jan 26;145(1):20-6. Epub 2008 Sep 26.

Department of Surgery, Klinikum rechts der Isar, Munich, Germany.

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http://dx.doi.org/10.1016/j.surg.2008.08.009DOI Listing
January 2009

Reduced notch activity is associated with an impaired marginal zone B cell development and function in Sly1 mutant mice.

Mol Immunol 2009 Feb 31;46(5):969-77. Epub 2008 Oct 31.

Department of Surgery, TU Munich, Ismaninger Strasse 22, 81675 Munich, Germany.

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http://dx.doi.org/10.1016/j.molimm.2008.09.023DOI Listing
February 2009

Role of T cells for cytokine production and outcome in a model of acute septic peritonitis.

Shock 2009 Mar;31(3):245-50

Department of Surgery, Technische Universität München, Ismaninger Strasse 22, 81675 Munich, Germany.

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http://dx.doi.org/10.1097/SHK.0b013e31817fd02cDOI Listing
March 2009

Integrin subunit CD18 Is the T-lymphocyte receptor for the Helicobacter pylori vacuolating cytotoxin.

Cell Host Microbe 2008 Jan;3(1):20-9

Max von Pettenkofer-Institute for Hygiene and Medical Microbiology, Ludwig-Maximilians-University, Pettenkoferstrasse 9a, D-80336 Munich, Germany.

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http://dx.doi.org/10.1016/j.chom.2007.11.003DOI Listing
January 2008

Role of Toll-like receptor responses for sepsis pathogenesis.

Immunobiology 2007 26;212(9-10):715-22. Epub 2007 Nov 26.

Department of Surgery, Technische Universität München, Ismaninger Strasse 22, 81675, Munich, Germany.

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http://dx.doi.org/10.1016/j.imbio.2007.09.010DOI Listing
March 2008

Correlation of CK-20-positive cells in peripheral venous blood with serum CEA levels in patients with colorectal carcinoma.

World J Surg 2007 Dec;31(12):2329-34

Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaningerstrasse 22, 81675, Munich, Germany.

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http://dx.doi.org/10.1007/s00268-007-9149-5DOI Listing
December 2007

Negative regulation of TLR responses by the neuropeptide CGRP is mediated by the transcriptional repressor ICER.

J Immunol 2007 Jul;179(1):607-15

Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Ismaningerstrasse 22, Munich, Germany.

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http://dx.doi.org/10.4049/jimmunol.179.1.607DOI Listing
July 2007

Expression of osteopontin, a target gene of de-regulated Wnt signaling, predicts survival in colon cancer.

Int J Cancer 2007 Oct;121(8):1717-23

Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.1002/ijc.22868DOI Listing
October 2007

Use of procalcitonin for early prediction of lethal outcome of postoperative sepsis.

Am J Surg 2007 Jul;194(1):35-9

Department of Surgery, Klinikum rechts der Isar, Technische Universität, Ismaninger Str. 22, 81675 Munich, Germany.

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http://dx.doi.org/10.1016/j.amjsurg.2006.10.026DOI Listing
July 2007

Inhibition of interleukin-22 attenuates bacterial load and organ failure during acute polymicrobial sepsis.

Infect Immun 2007 Apr 29;75(4):1690-7. Epub 2007 Jan 29.

Department of Surgery, Technische Universität München, Ismaninger Strasse 22, 81675 Munich, Germany.

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http://dx.doi.org/10.1128/IAI.01564-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865721PMC
April 2007

Expression of the mitotic checkpoint gene MAD2L2 has prognostic significance in colon cancer.

Int J Cancer 2007 Jan;120(1):207-11

Department of Surgery, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.1002/ijc.22155DOI Listing
January 2007

Type I IFN modulates host defense and late hyperinflammation in septic peritonitis.

J Immunol 2006 Oct;177(8):5623-30

Department of Surgery, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.4049/jimmunol.177.8.5623DOI Listing
October 2006

Organ-specific role of MyD88 for gene regulation during polymicrobial peritonitis.

Infect Immun 2006 Jun;74(6):3618-32

Department of Surgery, Technische Universität München, Ismaningerstrasse 22, 81675 Munich, Germany.

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http://dx.doi.org/10.1128/IAI.01681-05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479251PMC
June 2006

Animal models of sepsis: setting the stage.

Nat Rev Drug Discov 2005 Oct;4(10):854-65

Department of Emergency Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nrd1854DOI Listing
October 2005

Attenuated pathogenesis of polymicrobial peritonitis in mice after TLR2 agonist pre-treatment involves ST2 up-regulation.

Int Immunol 2005 Aug 6;17(8):1035-46. Epub 2005 Jul 6.

Department of Surgery, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Strasse 22, Munich 81675, Germany.

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http://dx.doi.org/10.1093/intimm/dxh282DOI Listing
August 2005

Importance of integrin LFA-1 deactivation for the generation of immune responses.

J Exp Med 2005 Jun 13;201(12):1987-98. Epub 2005 Jun 13.

Department of Surgery, Immunology, and Hygiene, Technische Universität München, 81675 Munich, Germany.

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http://dx.doi.org/10.1084/jem.20041850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212031PMC
June 2005

Gene expression profiles of different clinical stages of colorectal carcinoma: toward a molecular genetic understanding of tumor progression.

Int J Colorectal Dis 2005 Sep 10;20(5):391-402. Epub 2005 May 10.

Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaningerstrasse 22, 81675 Munich, Germany.

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http://dx.doi.org/10.1007/s00384-004-0722-1DOI Listing
September 2005

Prognostic impact of CK-20-positive cells in peripheral venous blood of patients with gastrointestinal carcinoma.

World J Surg 2005 Apr;29(4):422-8

Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Chirurgisch-Onkologisches Labor K049. Ismaningerstr 22, 81675, Munich, Germany.

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http://dx.doi.org/10.1007/s00268-004-7662-3DOI Listing
April 2005

Impact of interleukin-12, oxidative burst, and iNOS on the survival of murine fecal peritonitis.

Int J Colorectal Dis 2006 Jan 9;21(1):64-70. Epub 2005 Mar 9.

Chirurgische Klinik und Poliklinik, Technischen Universität München, Munich, Germany.

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http://dx.doi.org/10.1007/s00384-004-0707-0DOI Listing
January 2006

Current and future concepts of abdominal sepsis.

World J Surg 2005 Jan;29(1):3-9

Department of Surgery, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany.

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http://dx.doi.org/10.1007/s00268-004-7769-6DOI Listing
January 2005

CC chemokine receptor 2 regulates leukocyte recruitment and IL-10 production during acute polymicrobial sepsis.

Eur J Immunol 2004 Dec;34(12):3664-73

Department of Surgery, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.1002/eji.200425294DOI Listing
December 2004

Telomere length and human telomerase reverse transcriptase expression as markers for progression and prognosis of colorectal carcinoma.

J Clin Oncol 2004 May;22(10):1807-14

Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany.

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http://dx.doi.org/10.1200/JCO.2004.09.160DOI Listing
May 2004

Identification of a TLR4- and TRIF-dependent activation program of dendritic cells.

Eur J Immunol 2004 Feb;34(2):558-64

Department of Surgery, Technical University Munich, Munich, Germany.

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http://dx.doi.org/10.1002/eji.200324714DOI Listing
February 2004

Synthesis and structure-activity relationship of mannose-based peptidomimetics selectively blocking integrin alpha4beta7 binding to mucosal addressin cell adhesion molecule-1.

J Med Chem 2003 Dec;46(26):5752-62

Institut für Organische Chemie and Biochemie, Technische Universität München, Lichtenberg Strasse 4, 85747 Garching, Germany.

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http://dx.doi.org/10.1021/jm020487hDOI Listing
December 2003

Activated alpha4 integrins are preferentially expressed on immature thymocytes and activated T cells.

Dev Immunol 2002 Jun;9(2):73-84

Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama at Birmingham, 378 Wallace Tumor Institute, 1824 6th Avenue South, Birmingham, AL 35294-3300, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276093PMC
http://dx.doi.org/10.1080/1044667021000024229DOI Listing
June 2002

Synthesis and NMR structure of peptidomimetic alpha4beta7-integrin antagonists.

Chembiochem 2002 Jun;3(6):575-8

Institut für Organische Chemie und Biochemie, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching, Germany.

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http://dx.doi.org/10.1002/1439-7633(20020603)3:6<575::AID-CBIC575>3.0.CO;2-7DOI Listing
June 2002

Cutting edge: myeloid differentiation factor 88 deficiency improves resistance against sepsis caused by polymicrobial infection.

J Immunol 2002 Sep;169(6):2823-7

Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.4049/jimmunol.169.6.2823DOI Listing
September 2002

Combinatorial and rational strategies to develop nonpeptidic alpha4beta7-integrin antagonists from cyclic peptides.

Angew Chem Int Ed Engl 2002 Aug;41(16):3007-11

Institut für Organische Chemie und Biochemie, Technische Universität München, Lichtenbergstrasse 4, 85 747 Garching, Germany.

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http://dx.doi.org/10.1002/1521-3773(20020816)41:16<3007::AID-ANIE3007>3.0.CO;2-3DOI Listing
August 2002

Regulation and function of the CGRP receptor complex in human granulopoiesis.

Exp Hematol 2002 Apr;30(4):306-12

Department of Surgery, Klinikum rechts der Isar, Technische Universität, Ismaninger Strasse 22, 81675 Munich, Germany.

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http://dx.doi.org/10.1016/s0301-472x(02)00772-5DOI Listing
April 2002

Design, Synthesis, and Biological Evaluation of alpha(4)beta(1) Integrin Antagonists Based on beta-D-Mannose as Rigid Scaffold.

Angew Chem Int Ed Engl 2001 Oct;40(20):3870-3873

Institut für Organische Chemie und Biochemie Technische Universität München Lichtenbergstrasse 4, 85747 Garching (Germany).

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October 2001

Design, Synthesis, and Biological Evaluation of α β Integrin Antagonists Based on β-D-Mannose as Rigid Scaffold.

Angew Chem Int Ed Engl 2001 Oct;40(20):3870-3873

Institut für Organische Chemie und Biochemie Technische Universität München Lichtenbergstrasse 4, 85747 Garching (Germany) Fax: (+49) 89-289-13210.

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http://dx.doi.org/10.1002/1521-3773(20011015)40:20<3870::AID-ANIE3870>3.0.CO;2-XDOI Listing
October 2001