Bernhard Gentner

Bernhard Gentner

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Bernhard Gentner

Bernhard Gentner

Publications by authors named "Bernhard Gentner"

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Expanded circulating hematopoietic stem/progenitor cells as novel cell source for the treatment of TCIRG1 osteopetrosis.

Authors:
Valentina Capo Sara Penna Ivan Merelli Matteo Barcella Serena Scala Luca Basso-Ricci Elena Draghici Eleonora Palagano Erika Zonari Giacomo Desantis Paolo Uva Roberto Cusano Lucia Sergi Sergi Laura Crisafulli Despina Moshous Polina Stepensky Katarzyna Drabko Zühre Kaya Ekrem Unal Alper Gezdirici Giuseppe Menna Marta Serafini Alessandro Aiuti Silvia Laura Locatelli Carmelo Carlo-Stella Ansgar S Schulz Francesca Ficara Cristina Sobacchi Bernhard Gentner Anna Villa

Haematologica 2020 Jan 16. Epub 2020 Jan 16.

San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute;

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http://dx.doi.org/10.3324/haematol.2019.238261DOI Listing
January 2020

In Vivo Selection for Gene-Corrected HSPCs Advances Gene Therapy for a Rare Stem Cell Disease.

Authors:
Bernhard Gentner Luigi Naldini

Cell Stem Cell 2019 Nov;25(5):592-593

San Raffaele Telethon Institute for Gene Therapy, Milan, Italy; Vita Salute San Raffaele University, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.10.004DOI Listing
November 2019

MicroRNA-127-3p controls murine hematopoietic stem cell maintenance by limiting differentiation.

Authors:
Laura Crisafulli Sharon Muggeo Paolo Uva Yulei Wang Masayuki Iwasaki Silvia Locatelli Achille Anselmo Federico S Colombo Carmelo Carlo-Stella Michael L Cleary Anna Villa Bernhard Gentner Francesca Ficara

Haematologica 2019 Sep 21;104(9):1744-1755. Epub 2019 Feb 21.

UOS Milan Unit, Istituto di Ricerca Genetica e Biomedica (IRGB), CNR, Milan, Italy

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http://dx.doi.org/10.3324/haematol.2018.198499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717575PMC
September 2019

Assessing the Impact of Cyclosporin A on Lentiviral Transduction and Preservation of Human Hematopoietic Stem Cells in Clinically Relevant Gene Therapy Settings.

Authors:
Carolina Petrillo Andrea Calabria Francesco Piras Alessia Capotondo Giulio Spinozzi Ivan Cuccovillo Fabrizio Benedicenti Luigi Naldini Eugenio Montini Alessandra Biffi Bernhard Gentner Anna Kajaste-Rudnitski

Hum Gene Ther 2019 09 24;30(9):1133-1146. Epub 2019 May 24.

San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS Ospedale San Raffaele, Milan, Italy.

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http://dx.doi.org/10.1089/hum.2019.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761585PMC
September 2019

Acute myeloid leukaemia niche regulates response to L-asparaginase.

Authors:
Ilaria M Michelozzi Valentina Granata Giada De Ponti Gaia Alberti Chiara Tomasoni Laura Antolini Carlo Gambacorti-Passerini Bernhard Gentner Francesco Dazzi Andrea Biondi Tiziana Coliva Carmelo Rizzari Alice Pievani Marta Serafini

Br J Haematol 2019 Aug 1;186(3):420-430. Epub 2019 May 1.

M. Tettamanti Research Centre, Department of Paediatrics, University of Milano-Bicocca, Monza, Italy.

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http://dx.doi.org/10.1111/bjh.15920DOI Listing
August 2019

Targeting a Pre-existing Anti-transgene T Cell Response for Effective Gene Therapy of MPS-I in the Mouse Model of the Disease.

Authors:
Giorgia Squeri Laura Passerini Francesca Ferro Cecilia Laudisa Daniela Tomasoni Federica Deodato Maria Alice Donati Serena Gasperini Alessandro Aiuti Maria Ester Bernardo Bernhard Gentner Luigi Naldini Andrea Annoni Alessandra Biffi Silvia Gregori

Mol Ther 2019 07 19;27(7):1215-1227. Epub 2019 Apr 19.

San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612662PMC
July 2019

Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation.

Authors:
Cristina Toffalori Laura Zito Valentina Gambacorta Michela Riba Giacomo Oliveira Gabriele Bucci Matteo Barcella Orietta Spinelli Raffaella Greco Lara Crucitti Nicoletta Cieri Maddalena Noviello Francesco Manfredi Elisa Montaldo Renato Ostuni Matteo M Naldini Bernhard Gentner Miguel Waterhouse Robert Zeiser Jurgen Finke Maher Hanoun Dietrich W Beelen Ivana Gojo Leo Luznik Masahiro Onozawa Takanori Teshima Raynier Devillier Didier Blaise Constantijn J M Halkes Marieke Griffioen Matteo G Carrabba Massimo Bernardi Jacopo Peccatori Cristina Barlassina Elia Stupka Dejan Lazarevic Giovanni Tonon Alessandro Rambaldi Davide Cittaro Chiara Bonini Katharina Fleischhauer Fabio Ciceri Luca Vago

Nat Med 2019 04 25;25(4):603-611. Epub 2019 Mar 25.

Unit of Immunogenetics, Leukemia Genomics and Immunobiology, Division of Immunology, Transplantation and Infectious Disease, IRCCS San Raffaele Scientific Institute, Milano, Italy.

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http://dx.doi.org/10.1038/s41591-019-0400-zDOI Listing
April 2019

Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells.

Authors:
Carolina Petrillo Lucy G Thorne Giulia Unali Giulia Schiroli Anna M S Giordano Francesco Piras Ivan Cuccovillo Sarah J Petit Fatima Ahsan Mahdad Noursadeghi Simon Clare Pietro Genovese Bernhard Gentner Luigi Naldini Greg J Towers Anna Kajaste-Rudnitski

Cell Stem Cell 2018 12 8;23(6):820-832.e9. Epub 2018 Nov 8.

San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, MI 20132, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292841PMC
December 2018

Gene therapy for mucopolysaccharidoses: in vivo and ex vivo approaches.

Authors:
Alessandro Fraldi Marta Serafini Nicolina Cristina Sorrentino Bernhard Gentner Alessandro Aiuti Maria Ester Bernardo

Ital J Pediatr 2018 Nov 16;44(Suppl 2):130. Epub 2018 Nov 16.

San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20123, Milan, Italy.

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-018-0565-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238250PMC
November 2018

Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens.

Authors:
Giulia Escobar Luigi Barbarossa Giulia Barbiera Margherita Norelli Marco Genua Anna Ranghetti Tiziana Plati Barbara Camisa Chiara Brombin Davide Cittaro Andrea Annoni Attilio Bondanza Renato Ostuni Bernhard Gentner Luigi Naldini

Nat Commun 2018 07 24;9(1):2896. Epub 2018 Jul 24.

Vita-Salute San Raffaele University, 20132, Milan, Italy.

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http://dx.doi.org/10.1038/s41467-018-05315-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057972PMC
July 2018

Hematopoietic stem cell gene therapy for IFNγR1 deficiency protects mice from mycobacterial infections.

Authors:
Miriam Hetzel Adele Mucci Patrick Blank Ariane Hai Ha Nguyen Jan Schiller Olga Halle Mark-Philipp Kühnel Sandra Billig Robert Meineke Daniel Brand Vanessa Herder Wolfgang Baumgärtner Franz-Christoph Bange Ralph Goethe Danny Jonigk Reinhold Förster Bernhard Gentner Jean-Laurent Casanova Jacinta Bustamante Axel Schambach Ulrich Kalinke Nico Lachmann

Blood 2018 02 12;131(5):533-545. Epub 2017 Dec 12.

Institute of Experimental Hematology and.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2017-10
Publisher Site
http://dx.doi.org/10.1182/blood-2017-10-812859DOI Listing
February 2018

Dynamic Activity of miR-125b and miR-93 during Murine Neural Stem Cell Differentiation In Vitro and in the Subventricular Zone Neurogenic Niche.

Authors:
Annalisa Lattanzi Bernhard Gentner Daniela Corno Tiziano Di Tomaso Pieter Mestdagh Frank Speleman Luigi Naldini Angela Gritti

PLoS One 2013 27;8(6):e67411. Epub 2013 Jun 27.

San Raffaele Scientific Institute, Telethon Institute for Gene Therapy (TIGET), Milano, Italy ; Department of Experimental Medicine and Biochemical Sciences, Section of Biochemistry and Molecular Biology, University of Perugia, Perugia, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067411PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694868PMC
October 2017

Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cells.

Authors:
Francesco Piras Michela Riba Carolina Petrillo Dejan Lazarevic Ivan Cuccovillo Sara Bartolaccini Elia Stupka Bernhard Gentner Davide Cittaro Luigi Naldini Anna Kajaste-Rudnitski

EMBO Mol Med 2017 09;9(9):1198-1211

San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy

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http://dx.doi.org/10.15252/emmm.201707922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582409PMC
September 2017

NY-ESO-1 TCR single edited stem and central memory T cells to treat multiple myeloma without graft-versus-host disease.

Authors:
Sara Mastaglio Pietro Genovese Zulma Magnani Eliana Ruggiero Elisa Landoni Barbara Camisa Giulia Schiroli Elena Provasi Angelo Lombardo Andreas Reik Nicoletta Cieri Martina Rocchi Giacomo Oliveira Giulia Escobar Monica Casucci Bernhard Gentner Antonello Spinelli Anna Mondino Attilio Bondanza Luca Vago Maurilio Ponzoni Fabio Ciceri Michael C Holmes Luigi Naldini Chiara Bonini

Blood 2017 08 21;130(5):606-618. Epub 2017 Jun 21.

Experimental Hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, Program in Immunology and Bio-immunotherapy of Cancer.

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http://dx.doi.org/10.1182/blood-2016-08-732636DOI Listing
August 2017

Neonatal umbilical cord blood transplantation halts skeletal disease progression in the murine model of MPS-I.

Authors:
Isabella Azario Alice Pievani Federica Del Priore Laura Antolini Ludovica Santi Alessandro Corsi Lucia Cardinale Kazuki Sawamoto Francyne Kubaski Bernhard Gentner Maria Ester Bernardo Maria Grazia Valsecchi Mara Riminucci Shunji Tomatsu Alessandro Aiuti Andrea Biondi Marta Serafini

Sci Rep 2017 08 25;7(1):9473. Epub 2017 Aug 25.

Dulbecco Telethon Institute, Centro Ricerca M. Tettamanti, Department of Pediatrics, University of Milano-Bicocca, Monza, 20900, Italy.

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http://dx.doi.org/10.1038/s41598-017-09958-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573317PMC
August 2017

Plerixafor and G-CSF combination mobilizes hematopoietic stem and progenitors cells with a distinct transcriptional profile and a reduced homing capacity compared to plerixafor alone.

Authors:
Maria Rosa Lidonnici Annamaria Aprile Marta Claudia Frittoli Giacomo Mandelli Ylenia Paleari Antonello Spinelli Bernhard Gentner Matilde Zambelli Cristina Parisi Laura Bellio Elena Cassinerio Laura Zanaboni Maria Domenica Cappellini Fabio Ciceri Sarah Marktel Giuliana Ferrari

Haematologica 2017 04 29;102(4):e120-e124. Epub 2016 Dec 29.

San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET), Division of Regenerative Medicine, Stem Cells and Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy

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http://dx.doi.org/10.3324/haematol.2016.154740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395121PMC
April 2017

Efficient Ex Vivo Engineering and Expansion of Highly Purified Human Hematopoietic Stem and Progenitor Cell Populations for Gene Therapy.

Authors:
Erika Zonari Giacomo Desantis Carolina Petrillo Francesco E Boccalatte Maria Rosa Lidonnici Anna Kajaste-Rudnitski Alessandro Aiuti Giuliana Ferrari Luigi Naldini Bernhard Gentner

Stem Cell Reports 2017 04 16;8(4):977-990. Epub 2017 Mar 16.

San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Milan 20132, Italy; Hematology and Bone Marrow Transplantation Unit, IRCSS Ospedale San Raffaele, Milan 20132, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390102PMC
April 2017

Lentiviral Vector Gene Therapy Protects XCGD Mice From Acute Staphylococcus aureus Pneumonia and Inflammatory Response.

Authors:
Giada Farinelli Raisa Jofra Hernandez Alice Rossi Serena Ranucci Francesca Sanvito Maddalena Migliavacca Chiara Brombin Aleksandar Pramov Clelia Di Serio Chiara Bovolenta Bernhard Gentner Alessandra Bragonzi Alessandro Aiuti

Mol Ther 2016 10 26;24(10):1873-1880. Epub 2016 Jul 26.

San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1038/mt.2016.150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112042PMC
October 2016

Elderly patients > 65 years of age with acute myeloid leukemia and normal karyotype benefit from intensive therapeutic programs.

Authors:
Massimo Bernardi Matteo Carrabba Carlo Messina Raffaella Milani Elisa Sala Francesca Pavesi Bernhard Gentner Jacopo Peccatori Andrea Assanelli Sarah Marktel Consuelo Corti Alessandra Forcina Luca Vago Fabio Ciceri

Am J Hematol 2016 06 13;91(6):E302-3. Epub 2016 Apr 13.

Haematology and Bone Marrow Transplant Unit, IRCCS San Raffaele Scientific Institute, Milan, 20132, Italy.

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http://dx.doi.org/10.1002/ajh.24345DOI Listing
June 2016

miRNA-126 Orchestrates an Oncogenic Program in B Cell Precursor Acute Lymphoblastic Leukemia.

Authors:
Silvia Nucera Alice Giustacchini Francesco Boccalatte Andrea Calabria Cristiana Fanciullo Tiziana Plati Anna Ranghetti Jose Garcia-Manteiga Davide Cittaro Fabrizio Benedicenti Eric R Lechman John E Dick Maurilio Ponzoni Fabio Ciceri Eugenio Montini Bernhard Gentner Luigi Naldini

Cancer Cell 2016 06;29(6):905-921

San Raffaele Telethon Institute for Gene Therapy, 20132 Milan, Italy; Vita Salute San Raffaele University, 20132 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.05.007DOI Listing
June 2016

miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells.

Authors:
Eric R Lechman Bernhard Gentner Stanley W K Ng Erwin M Schoof Peter van Galen James A Kennedy Silvia Nucera Fabio Ciceri Kerstin B Kaufmann Naoya Takayama Stephanie M Dobson Aaron Trotman-Grant Gabriela Krivdova Janneke Elzinga Amanda Mitchell Björn Nilsson Karin G Hermans Kolja Eppert Rene Marke Ruth Isserlin Veronique Voisin Gary D Bader Peter W Zandstra Todd R Golub Benjamin L Ebert Jun Lu Mark Minden Jean C Y Wang Luigi Naldini John E Dick

Cancer Cell 2016 Apr;29(4):602-606

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http://dx.doi.org/10.1016/j.ccell.2016.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628169PMC
April 2016

miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells.

Authors:
Eric R Lechman Bernhard Gentner Stanley W K Ng Erwin M Schoof Peter van Galen James A Kennedy Silvia Nucera Fabio Ciceri Kerstin B Kaufmann Naoya Takayama Stephanie M Dobson Aaron Trotman-Grant Gabriela Krivdova Janneke Elzinga Amanda Mitchell Björn Nilsson Karin G Hermans Kolja Eppert Rene Marke Ruth Isserlin Veronique Voisin Gary D Bader Peter W Zandstra Todd R Golub Benjamin L Ebert Jun Lu Mark Minden Jean C Y Wang Luigi Naldini John E Dick

Cancer Cell 2016 Feb 28;29(2):214-28. Epub 2016 Jan 28.

Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1L7, Canada; Princess Margaret Cancer Research Tower, Room 8-301, 101 College Street, Toronto M5G 1L7, Canada. Electronic address:

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http://www.cell.com/cancer-cell/pdf/S1535-6108(15)00475-4.pd
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http://linkinghub.elsevier.com/retrieve/pii/S153561081500475
Publisher Site
http://dx.doi.org/10.1016/j.ccell.2015.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749543PMC
February 2016

MicroRNA-223 dose levels fine tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia.

Authors:
Bernhard Gentner Nicole Pochert Arefeh Rouhi Francesco Boccalatte Tiziana Plati Tobias Berg Su Ming Sun Sarah M Mah Milijana Mirkovic-Hösle Jens Ruschmann Andrew Muranyi Simon Leierseder Bob Argiropoulos Daniel T Starczynowski Aly Karsan Michael Heuser Donna Hogge Fernando D Camargo Stefan Engelhardt Hartmut Döhner Christian Buske Mojca Jongen-Lavrencic Luigi Naldini R Keith Humphries Florian Kuchenbauer

Exp Hematol 2015 Oct 8;43(10):858-868.e7. Epub 2015 Jul 8.

Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2015.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860732PMC
October 2015

Design of a regulated lentiviral vector for hematopoietic stem cell gene therapy of globoid cell leukodystrophy.

Authors:
Silvia Ungari Annita Montepeloso Francesco Morena Fabienne Cocchiarella Alessandra Recchia Sabata Martino Bernhard Gentner Luigi Naldini Alessandra Biffi

Mol Ther Methods Clin Dev 2015 14;2:15038. Epub 2015 Oct 14.

San Raffaele Telethon Institute for Gene Therapy , San Raffaele Scientific Institute , Milan, Italy ; Vita-Salute San Raffaele University , Milan, Italy.

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http://dx.doi.org/10.1038/mtm.2015.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605225PMC
October 2015

Dual-regulated lentiviral vector for gene therapy of X-linked chronic granulomatosis.

Authors:
Maria Chiriaco Giada Farinelli Valentina Capo Erika Zonari Samantha Scaramuzza Gigliola Di Matteo Lucia Sergi Sergi Maddalena Migliavacca Raisa Jofra Hernandez Ferdinando Bombelli Ezio Giorda Anna Kajaste-Rudnitski Didier Trono Manuel Grez Paolo Rossi Andrea Finocchi Luigi Naldini Bernhard Gentner Alessandro Aiuti

Mol Ther 2014 Aug 29;22(8):1472-1483. Epub 2014 May 29.

Department of Pediatrics, Children's Hospital Bambino Gesù and University of Rome Tor Vergata School of Medicine, Rome, Italy; San Raffaele Telethon Institute for Gene Therapy (TIGET), Scientific Institute HS Raffaele, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1038/mt.2014.87DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435596PMC
August 2014

Targeted genome editing in human repopulating haematopoietic stem cells.

Authors:
Pietro Genovese Giulia Schiroli Giulia Escobar Tiziano Di Tomaso Claudia Firrito Andrea Calabria Davide Moi Roberta Mazzieri Chiara Bonini Michael C Holmes Philip D Gregory Mirjam van der Burg Bernhard Gentner Eugenio Montini Angelo Lombardo Luigi Naldini

Nature 2014 Jun 28;510(7504):235-240. Epub 2014 May 28.

TIGET, San Raffaele Telethon Institute for Gene Therapy, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1038/nature13420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082311PMC
June 2014

microRNA-125 distinguishes developmentally generated and adult-born olfactory bulb interneurons.

Authors:
Malin Akerblom Rebecca Petri Rohit Sachdeva Thies Klussendorf Bengt Mattsson Bernhard Gentner Johan Jakobsson

Development 2014 Apr 5;141(7):1580-8. Epub 2014 Mar 5.

Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University, 221 84 Lund, Sweden.

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http://dx.doi.org/10.1242/dev.101659DOI Listing
April 2014

Engineered tumor-infiltrating macrophages as gene delivery vehicles for interferon-α activates immunity and inhibits breast cancer progression.

Authors:
Giulia Escobar Bernhard Gentner Luigi Naldini Roberta Mazzieri

Oncoimmunology 2014 29;3:e28696. Epub 2014 Apr 29.

The University of Queensland; Woolloongabba, QC Australia.

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http://dx.doi.org/10.4161/onci.28696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091049PMC
April 2014

Genetic engineering of hematopoiesis for targeted IFN-α delivery inhibits breast cancer progression.

Authors:
Giulia Escobar Davide Moi Anna Ranghetti Pinar Ozkal-Baydin Mario Leonardo Squadrito Anna Kajaste-Rudnitski Attilio Bondanza Bernhard Gentner Michele De Palma Roberta Mazzieri Luigi Naldini

Sci Transl Med 2014 Jan;6(217):217ra3

Vita-Salute San Raffaele University, 20132 Milan, Italy.

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http://dx.doi.org/10.1126/scitranslmed.3006353DOI Listing
January 2014

CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma.

Authors:
Monica Casucci Benedetta Nicolis di Robilant Laura Falcone Barbara Camisa Margherita Norelli Pietro Genovese Bernhard Gentner Fabiana Gullotta Maurilio Ponzoni Massimo Bernardi Magda Marcatti Aurore Saudemont Claudio Bordignon Barbara Savoldo Fabio Ciceri Luigi Naldini Gianpietro Dotti Chiara Bonini Attilio Bondanza

Blood 2013 Nov 9;122(20):3461-72. Epub 2013 Sep 9.

Leukemia Immunotherapy Group, San Raffaele Scientific Institute, Milan, Italy;

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http://dx.doi.org/10.1182/blood-2013-04-493361DOI Listing
November 2013

MicroRNA-126-mediated control of cell fate in B-cell myeloid progenitors as a potential alternative to transcriptional factors.

Authors:
Kazuki Okuyama Tomokatsu Ikawa Bernhard Gentner Katsuto Hozumi Ratanakanit Harnprasopwat Jun Lu Riu Yamashita Daon Ha Takae Toyoshima Bidisha Chanda Toyotaka Kawamata Kazuaki Yokoyama Shusheng Wang Kiyoshi Ando Harvey F Lodish Arinobu Tojo Hiroshi Kawamoto Ai Kotani

Proc Natl Acad Sci U S A 2013 Aug 26;110(33):13410-5. Epub 2013 Jul 26.

Division of Hematological Malignancy, Regenerative Medical Science, Tokai University School of Medicine, Kanagawa 259-1193, Japan.

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http://dx.doi.org/10.1073/pnas.1220710110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746909PMC
August 2013

A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice.

Authors:
Erika Zonari Ferdinando Pucci Massimo Saini Roberta Mazzieri Letterio S Politi Bernhard Gentner Luigi Naldini

Blood 2013 Jul 13;122(2):243-52. Epub 2013 Mar 13.

San Raffaele Telethon Institute for Gene Therapy and Division of Regenerative Medicine, Gene Therapy and Stem Cells, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy.

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http://dx.doi.org/10.1182/blood-2012-08-449306DOI Listing
July 2013

miR-142-3p prevents macrophage differentiation during cancer-induced myelopoiesis.

Authors:
Nada Sonda Francesca Simonato Elisa Peranzoni Bianca Calì Stefania Bortoluzzi Andrea Bisognin Ena Wang Francesco M Marincola Luigi Naldini Bernhard Gentner Christian Trautwein Sara Dutton Sackett Paola Zanovello Barbara Molon Vincenzo Bronte

Immunity 2013 Jun;38(6):1236-49

Department of Surgery, Oncology and Gastroenterology, Oncology and Immunology Section, University of Padua, 35128 Padua, Italy.

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http://dx.doi.org/10.1016/j.immuni.2013.06.004DOI Listing
June 2013

A double-switch vector system positively regulates transgene expression by endogenous microRNA expression (miR-ON vector).

Authors:
Mario Amendola Alice Giustacchini Bernhard Gentner Luigi Naldini

Mol Ther 2013 May 26;21(5):934-46. Epub 2013 Feb 26.

Division of Regenerative Medicine, Gene Therapy and Stem Cells, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1038/mt.2013.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666624PMC
May 2013

Attenuation of miR-126 activity expands HSC in vivo without exhaustion.

Authors:
Eric R Lechman Bernhard Gentner Peter van Galen Alice Giustacchini Massimo Saini Francesco E Boccalatte Hidefumi Hiramatsu Umberto Restuccia Angela Bachi Veronique Voisin Gary D Bader John E Dick Luigi Naldini

Cell Stem Cell 2012 Dec 8;11(6):799-811. Epub 2012 Nov 8.

Campbell Family Institute, Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.

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http://dx.doi.org/10.1016/j.stem.2012.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517970PMC
December 2012

MicroRNA-124 is a subventricular zone neuronal fate determinant.

Authors:
Malin Åkerblom Rohit Sachdeva Isabelle Barde Sonia Verp Bernhard Gentner Didier Trono Johan Jakobsson

J Neurosci 2012 Jun;32(26):8879-89

Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University, 22184 Lund, Sweden.

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http://dx.doi.org/10.1523/JNEUROSCI.0558-12.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434222PMC
June 2012

A microRNA-based system for selecting and maintaining the pluripotent state in human induced pluripotent stem cells.

Authors:
Bruno Di Stefano Sara Martina Maffioletti Bernhard Gentner Federica Ungaro Giulia Schira Luigi Naldini Vania Broccoli

Stem Cells 2011 Nov;29(11):1684-95

Division of Neuroscience, Stem Cells and Neurogenesis Unit, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1002/stem.726DOI Listing
November 2011

Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells.

Authors:
Roberta Mazzieri Ferdinando Pucci Davide Moi Erika Zonari Anna Ranghetti Alvise Berti Letterio S Politi Bernhard Gentner Jeffrey L Brown Luigi Naldini Michele De Palma

Cancer Cell 2011 Apr;19(4):512-26

Angiogenesis and Tumor Targeting Research Unit, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1016/j.ccr.2011.02.005DOI Listing
April 2011

Identification of hematopoietic stem cell-specific miRNAs enables gene therapy of globoid cell leukodystrophy.

Authors:
Bernhard Gentner Ilaria Visigalli Hidefumi Hiramatsu Eric Lechman Silvia Ungari Alice Giustacchini Giulia Schira Mario Amendola Angelo Quattrini Sabata Martino Aldo Orlacchio John E Dick Alessandra Biffi Luigi Naldini

Sci Transl Med 2010 Nov;2(58):58ra84

San Raffaele Telethon Institute for Gene Therapy, San Raffaele Scientific Institute, Milan 20132, Italy.

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http://stm.sciencemag.org/content/scitransmed/2/58/58ra84.fu
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http://stm.sciencemag.org/cgi/doi/10.1126/scitranslmed.30015
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http://dx.doi.org/10.1126/scitranslmed.3001522DOI Listing
November 2010

The galactocerebrosidase enzyme contributes to the maintenance of a functional hematopoietic stem cell niche.

Authors:
Ilaria Visigalli Silvia Ungari Sabata Martino Hyejung Park Martina Cesani Bernhard Gentner Lucia Sergi Sergi Aldo Orlacchio Luigi Naldini Alessandra Biffi

Blood 2010 Sep 28;116(11):1857-66. Epub 2010 May 28.

San Raffaele Telethon Institute for Gene Therapy, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy.

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http://dx.doi.org/10.1182/blood-2009-12-256461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173985PMC
September 2010

Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors.

Authors:
Rohit Sachdeva Marie E Jönsson Jenny Nelander Agnete Kirkeby Carolina Guibentif Bernhard Gentner Luigi Naldini Anders Björklund Malin Parmar Johan Jakobsson

Proc Natl Acad Sci U S A 2010 Jun 7;107(25):11602-7. Epub 2010 Jun 7.

Department of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, 221 84 Lund, Sweden.

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http://dx.doi.org/10.1073/pnas.1006568107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895063PMC
June 2010

Regulated and multiple miRNA and siRNA delivery into primary cells by a lentiviral platform.

Authors:
Mario Amendola Laura Passerini Ferdinando Pucci Bernhard Gentner Rosa Bacchetta Luigi Naldini

Mol Ther 2009 Jun 17;17(6):1039-52. Epub 2009 Mar 17.

San Raffaele Telethon Institute for Gene Therapy, Milan, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S152500161631810
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http://dx.doi.org/10.1038/mt.2009.48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835189PMC
June 2009

Stable knockdown of microRNA in vivo by lentiviral vectors.

Authors:
Bernhard Gentner Giulia Schira Alice Giustacchini Mario Amendola Brian D Brown Maurilio Ponzoni Luigi Naldini

Nat Methods 2009 Jan 30;6(1):63-6. Epub 2008 Nov 30.

San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, Milan, Italy.

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http://dx.doi.org/10.1038/nmeth.1277DOI Listing
January 2009

Differences in the gene expression profile of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in primary colorectal tumors and their synchronous liver metastases.

Authors:
Bernhard Gentner Axel Wein Roland S Croner Isabel Zeittraeger Ralph M Wirtz Franz Roedel Arno Dimmler Laure Dorlaque Werner Hohenberger Eckhart G Hahn Wolfgang M Brueckl

Anticancer Res 2009 Jan;29(1):67-74

Department of Medicine, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany.

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January 2009

Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state.

Authors:
Brian D Brown Bernhard Gentner Alessio Cantore Silvia Colleoni Mario Amendola Anna Zingale Alessia Baccarini Giovanna Lazzari Cesare Galli Luigi Naldini

Nat Biotechnol 2007 Dec 16;25(12):1457-67. Epub 2007 Nov 16.

San Raffaele Telethon Institute for Gene Therapy, San Raffaele Scientific Institute, via Olgettina, 58, 20132 Milan, Italy.

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http://dx.doi.org/10.1038/nbt1372DOI Listing
December 2007

Genetic testing for germline mutations of the APC gene in patients with apparently sporadic desmoid tumors but a family history of colorectal carcinoma.

Authors:
Wolfgang M Brueckl Wolfgang G Ballhausen Thomas Förtsch Klaus Günther Wolfgang Fiedler Bernhard Gentner Roland Croner Frank Boxberger Thomas Kirchner Eckhart G Hahn Werner Hohenberger Axel Wein

Dis Colon Rectum 2005 Jun;48(6):1275-81

Department of Internal Medicine I, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.

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http://dx.doi.org/10.1007/s10350-004-0949-5DOI Listing
June 2005

Clonal analysis of individual marrow-repopulating cells after experimental peripheral blood progenitor cell transplantation.

Authors:
K Zsuzsanna Nagy Stephanie Laufs Bernhard Gentner Sonja Naundorf Klaus Kuehlcke Julian Topaly Eike C Buss W Jens Zeller Stefan Fruehauf

Stem Cells 2004 ;22(4):570-9

German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1634/stemcells.22-4-570DOI Listing
March 2005

Perioperative complications in patients undergoing major liver resection with or without neoadjuvant chemotherapy.

Authors:
Alexander A Parikh Bernhard Gentner Tsung-Teh Wu Steven A Curley Lee M Ellis Jean-Nicolas Vauthey

J Gastrointest Surg 2003 Dec;7(8):1082-8

Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://link.springer.com/content/pdf/10.1016/j.gassur.2003.0
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http://dx.doi.org/10.1016/j.gassur.2003.08.005DOI Listing
December 2003

Retroviral vector integration occurs in preferred genomic targets of human bone marrow-repopulating cells.

Authors:
Stephanie Laufs Bernhard Gentner K Zsuzsanna Nagy Anna Jauch Axel Benner Sonja Naundorf Klaus Kuehlcke Bernhard Schiedlmeier Anthony D Ho W Jens Zeller Stefan Fruehauf

Blood 2003 Mar 7;101(6):2191-8. Epub 2002 Nov 7.

German Cancer Research Center, Research Program Diagnostics and Experimental Therapy, Heidelberg, Germany.

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http://dx.doi.org/10.1182/blood-2002-02-0627DOI Listing
March 2003