Bernhard Gentner

Unit of Immunogenetics, Leukemia Genomics and Immunobiology, Division of Immunology, Transplantation and Infectious Disease, IRCCS San Raffaele Scientific Institute, Milano, Italy.

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April 2019

MicroRNA-127-3p controls murine hematopoietic stem cell maintenance by limiting differentiation.

Authors:

Laura Crisafulli Sharon Muggeo Paolo Uva Yulei Wang Masayuki Iwasaki Silvia Locatelli Achille Anselmo Federico S Colombo Carmelo Carlo-Stella Michael L Cleary Anna Villa Bernhard Gentner Francesca Ficara

Haematologica 2019 09 21;104(9):1744-1755. Epub 2019 Feb 21.

UOS Milan Unit, Istituto di Ricerca Genetica e Biomedica (IRGB), CNR, Milan, Italy

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September 2019

Gene therapy for mucopolysaccharidoses: in vivo and ex vivo approaches.

Authors:

Alessandro Fraldi Marta Serafini Nicolina Cristina Sorrentino Bernhard Gentner Alessandro Aiuti Maria Ester Bernardo

Ital J Pediatr 2018 Nov 16;44(Suppl 2):130. Epub 2018 Nov 16.

San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20123, Milan, Italy.

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November 2018

Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells.

Authors:

Carolina Petrillo Lucy G Thorne Giulia Unali Giulia Schiroli Anna M S Giordano Francesco Piras Ivan Cuccovillo Sarah J Petit Fatima Ahsan Mahdad Noursadeghi Simon Clare Pietro Genovese Bernhard Gentner Luigi Naldini Greg J Towers Anna Kajaste-Rudnitski

Cell Stem Cell 2018 12 8;23(6):820-832.e9. Epub 2018 Nov 8.

San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, MI 20132, Italy. Electronic address:

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December 2018

Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens.

Authors:

Giulia Escobar Luigi Barbarossa Giulia Barbiera Margherita Norelli Marco Genua Anna Ranghetti Tiziana Plati Barbara Camisa Chiara Brombin Davide Cittaro Andrea Annoni Attilio Bondanza Renato Ostuni Bernhard Gentner Luigi Naldini

Nat Commun 2018 07 24;9(1):2896. Epub 2018 Jul 24.

Vita-Salute San Raffaele University, 20132, Milan, Italy.

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July 2018

Hematopoietic stem cell gene therapy for IFNγR1 deficiency protects mice from mycobacterial infections.

Blood 2018 02 12;131(5):533-545. Epub 2017 Dec 12.

Institute of Experimental Hematology and.

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February 2018

Neonatal umbilical cord blood transplantation halts skeletal disease progression in the murine model of MPS-I.

Authors:

Isabella Azario Alice Pievani Federica Del Priore Laura Antolini Ludovica Santi Alessandro Corsi Lucia Cardinale Kazuki Sawamoto Francyne Kubaski Bernhard Gentner Maria Ester Bernardo Maria Grazia Valsecchi Mara Riminucci Shunji Tomatsu Alessandro Aiuti Andrea Biondi Marta Serafini

Sci Rep 2017 08 25;7(1):9473. Epub 2017 Aug 25.

Dulbecco Telethon Institute, Centro Ricerca M. Tettamanti, Department of Pediatrics, University of Milano-Bicocca, Monza, 20900, Italy.

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August 2017

Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cells.

Authors:

Francesco Piras Michela Riba Carolina Petrillo Dejan Lazarevic Ivan Cuccovillo Sara Bartolaccini Elia Stupka Bernhard Gentner Davide Cittaro Luigi Naldini Anna Kajaste-Rudnitski

EMBO Mol Med 2017 09;9(9):1198-1211

San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy

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September 2017

NY-ESO-1 TCR single edited stem and central memory T cells to treat multiple myeloma without graft-versus-host disease.

Blood 2017 08 21;130(5):606-618. Epub 2017 Jun 21.

Experimental Hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, Program in Immunology and Bio-immunotherapy of Cancer.

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August 2017

Efficient Ex Vivo Engineering and Expansion of Highly Purified Human Hematopoietic Stem and Progenitor Cell Populations for Gene Therapy.

Authors:

Erika Zonari Giacomo Desantis Carolina Petrillo Francesco E Boccalatte Maria Rosa Lidonnici Anna Kajaste-Rudnitski Alessandro Aiuti Giuliana Ferrari Luigi Naldini Bernhard Gentner

Stem Cell Reports 2017 04 16;8(4):977-990. Epub 2017 Mar 16.

San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Milan 20132, Italy; Hematology and Bone Marrow Transplantation Unit, IRCSS Ospedale San Raffaele, Milan 20132, Italy. Electronic address:

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April 2017

Plerixafor and G-CSF combination mobilizes hematopoietic stem and progenitors cells with a distinct transcriptional profile and a reduced homing capacity compared to plerixafor alone.

Authors:

Maria Rosa Lidonnici Annamaria Aprile Marta Claudia Frittoli Giacomo Mandelli Ylenia Paleari Antonello Spinelli Bernhard Gentner Matilde Zambelli Cristina Parisi Laura Bellio Elena Cassinerio Laura Zanaboni Maria Domenica Cappellini Fabio Ciceri Sarah Marktel Giuliana Ferrari

Haematologica 2017 04 29;102(4):e120-e124. Epub 2016 Dec 29.

San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET), Division of Regenerative Medicine, Stem Cells and Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy

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April 2017

Lentiviral Vector Gene Therapy Protects XCGD Mice From Acute Staphylococcus aureus Pneumonia and Inflammatory Response.

Authors:

Giada Farinelli Raisa Jofra Hernandez Alice Rossi Serena Ranucci Francesca Sanvito Maddalena Migliavacca Chiara Brombin Aleksandar Pramov Clelia Di Serio Chiara Bovolenta Bernhard Gentner Alessandra Bragonzi Alessandro Aiuti

Mol Ther 2016 10 26;24(10):1873-1880. Epub 2016 Jul 26.

San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), San Raffaele Scientific Institute, Milan, Italy.

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October 2016

miRNA-126 Orchestrates an Oncogenic Program in B Cell Precursor Acute Lymphoblastic Leukemia.

Authors:

Silvia Nucera Alice Giustacchini Francesco Boccalatte Andrea Calabria Cristiana Fanciullo Tiziana Plati Anna Ranghetti Jose Garcia-Manteiga Davide Cittaro Fabrizio Benedicenti Eric R Lechman John E Dick Maurilio Ponzoni Fabio Ciceri Eugenio Montini Bernhard Gentner Luigi Naldini

Cancer Cell 2016 06;29(6):905-921

San Raffaele Telethon Institute for Gene Therapy, 20132 Milan, Italy; Vita Salute San Raffaele University, 20132 Milan, Italy. Electronic address:

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June 2016

miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells.

Cancer Cell 2016 Apr;29(4):602-606

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April 2016

Elderly patients > 65 years of age with acute myeloid leukemia and normal karyotype benefit from intensive therapeutic programs.

Authors:

Massimo Bernardi Matteo Carrabba Carlo Messina Raffaella Milani Elisa Sala Francesca Pavesi Bernhard Gentner Jacopo Peccatori Andrea Assanelli Sarah Marktel Consuelo Corti Alessandra Forcina Luca Vago Fabio Ciceri

Am J Hematol 2016 06 13;91(6):E302-3. Epub 2016 Apr 13.

Haematology and Bone Marrow Transplant Unit, IRCCS San Raffaele Scientific Institute, Milan, 20132, Italy.

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June 2016

miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells.

Cancer Cell 2016 Feb 28;29(2):214-28. Epub 2016 Jan 28.

Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1L7, Canada; Princess Margaret Cancer Research Tower, Room 8-301, 101 College Street, Toronto M5G 1L7, Canada. Electronic address:

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February 2016

Design of a regulated lentiviral vector for hematopoietic stem cell gene therapy of globoid cell leukodystrophy.

Authors:

Silvia Ungari Annita Montepeloso Francesco Morena Fabienne Cocchiarella Alessandra Recchia Sabata Martino Bernhard Gentner Luigi Naldini Alessandra Biffi

Mol Ther Methods Clin Dev 2015 14;2:15038. Epub 2015 Oct 14.

San Raffaele Telethon Institute for Gene Therapy , San Raffaele Scientific Institute , Milan, Italy ; Vita-Salute San Raffaele University , Milan, Italy.

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October 2015

MicroRNA-223 dose levels fine tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia.

Exp Hematol 2015 Oct 8;43(10):858-868.e7. Epub 2015 Jul 8.

Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany. Electronic address:

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October 2015

Engineered tumor-infiltrating macrophages as gene delivery vehicles for interferon-α activates immunity and inhibits breast cancer progression.

Authors:

Giulia Escobar Bernhard Gentner Luigi Naldini Roberta Mazzieri

Oncoimmunology 2014;3:e28696. Epub 2014 Apr 29.

The University of Queensland; Woolloongabba, QC Australia.

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February 2021

Targeted genome editing in human repopulating haematopoietic stem cells.

Authors:

Pietro Genovese Giulia Schiroli Giulia Escobar Tiziano Di Tomaso Claudia Firrito Andrea Calabria Davide Moi Roberta Mazzieri Chiara Bonini Michael C Holmes Philip D Gregory Mirjam van der Burg Bernhard Gentner Eugenio Montini Angelo Lombardo Luigi Naldini

Nature 2014 Jun 28;510(7504):235-240. Epub 2014 May 28.

TIGET, San Raffaele Telethon Institute for Gene Therapy, San Raffaele Scientific Institute, Milan, Italy.

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June 2014

Dual-regulated lentiviral vector for gene therapy of X-linked chronic granulomatosis.

Authors:

Maria Chiriaco Giada Farinelli Valentina Capo Erika Zonari Samantha Scaramuzza Gigliola Di Matteo Lucia Sergi Sergi Maddalena Migliavacca Raisa Jofra Hernandez Ferdinando Bombelli Ezio Giorda Anna Kajaste-Rudnitski Didier Trono Manuel Grez Paolo Rossi Andrea Finocchi Luigi Naldini Bernhard Gentner Alessandro Aiuti

Mol Ther 2014 Aug 29;22(8):1472-1483. Epub 2014 May 29.

Department of Pediatrics, Children's Hospital Bambino Gesù and University of Rome Tor Vergata School of Medicine, Rome, Italy; San Raffaele Telethon Institute for Gene Therapy (TIGET), Scientific Institute HS Raffaele, Milan, Italy. Electronic address:

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August 2014

microRNA-125 distinguishes developmentally generated and adult-born olfactory bulb interneurons.

Authors:

Malin Akerblom Rebecca Petri Rohit Sachdeva Thies Klussendorf Bengt Mattsson Bernhard Gentner Johan Jakobsson

Development 2014 Apr 5;141(7):1580-8. Epub 2014 Mar 5.

Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University, 221 84 Lund, Sweden.

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April 2014

Genetic engineering of hematopoiesis for targeted IFN-α delivery inhibits breast cancer progression.

Authors:

Giulia Escobar Davide Moi Anna Ranghetti Pinar Ozkal-Baydin Mario Leonardo Squadrito Anna Kajaste-Rudnitski Attilio Bondanza Bernhard Gentner Michele De Palma Roberta Mazzieri Luigi Naldini

Sci Transl Med 2014 Jan;6(217):217ra3

Vita-Salute San Raffaele University, 20132 Milan, Italy.

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January 2014

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