Bernd Meibohm

Bernd Meibohm

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Bernd Meibohm

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Immunogenicity in Clinical Practice and Drug Development: When is it Significant?

Authors:
Valentina Shakhnovich Bernd Meibohm Amy Rosenberg Andrzej M Kierzek Rachel Hasenkamp Ryan S Funk Craig J Thalhauser Piet H van der Graaf Yow-Ming C Wang Lora Hamuro

Clin Transl Sci 2019 Nov 25. Epub 2019 Nov 25.

Clinical Pharmacology & Pharmacometrics, Bristol-Myers Squibb, Princeton, New Jersey, USA.

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http://dx.doi.org/10.1111/cts.12717DOI Listing
November 2019

Cross-Linked Polyphenol-Based Drug Nano-Self-Assemblies Engineered to Blockade Prostate Cancer Senescence.

Authors:
Prashanth K B Nagesh Pallabita Chowdhury Elham Hatami Sonam Kumari Vivek Kumar Kashyap Manish K Tripathi Santosh Wagh Bernd Meibohm Subhash C Chauhan Meena Jaggi Murali M Yallapu

ACS Appl Mater Interfaces 2019 Oct 8;11(42):38537-38554. Epub 2019 Oct 8.

Department of Microbiology and Immunology , School of Medicine, University of Texas Rio Grande Valley , McAllen , Texas 78504 , United States.

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http://dx.doi.org/10.1021/acsami.9b14738DOI Listing
October 2019

Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young infants.

Authors:
Evelyne Jacqz-Aigrain Stéphanie Leroux Alison H Thomson Karel Allegaert Edmund V Capparelli Valérie Biran Nicolas Simon Bernd Meibohm Yoke-Lin Lo Remedios Marques José-Esteban Peris Irja Lutsar Jumpei Saito Hidefumi Nakamura Johannes N van den Anker Mike Sharland Wei Zhao

J Antimicrob Chemother 2019 Aug;74(8):2128-2138

Department of Pediatric Pharmacology and Pharmacogenetics, Hôpital Robert Debré, APHP, Paris, France.

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http://dx.doi.org/10.1093/jac/dkz158DOI Listing
August 2019

Core Entrustable Professional Activities in Clinical Pharmacology for Entering Residency: Common Problem Drugs and How to Prescribe Them.

Authors:
Vera S Donnenberg Philip Chaikin Maja Mandic Bernd Meibohm John van den Anker Erin Rhinehart Anne N Nafziger James F Burris

J Clin Pharmacol 2019 Jul 15;59(7):915-922. Epub 2019 Feb 15.

The American College of Clinical Pharmacology, Ashburn, VA, USA.

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http://dx.doi.org/10.1002/jcph.1389DOI Listing
July 2019

Development and Characterization of a Dry Powder Formulation for Anti-Tuberculosis Drug Spectinamide 1599.

Authors:
Ian E Stewart Pradeep B Lukka Jiuyu Liu Bernd Meibohm Mercedes Gonzalez-Juarrero Miriam S Braunstein Richard E Lee Anthony J Hickey

Pharm Res 2019 Jul 18;36(9):136. Epub 2019 Jul 18.

Engineered Systems, RTI International, Durham, North Carolina, USA.

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http://dx.doi.org/10.1007/s11095-019-2666-8DOI Listing
July 2019

Sterilization of Mycobacterium tuberculosis infected samples using methanol preserves anti-tuberculosis drugs for subsequent pharmacological testing studies.

Authors:
Amanda Walz Pradeep B Lukka Camron Pearce Elizabeth Creissen Miriam Braunstein Anthony J Hickey Bernd Meibohm Mercedes Gonzalez-Juarrero

Tuberculosis (Edinb) 2019 07 6;117:52-55. Epub 2019 Jun 6.

Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, 80523, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tube.2019.06.002DOI Listing
July 2019

Tannic acid-inspired paclitaxel nanoparticles for enhanced anticancer effects in breast cancer cells.

Authors:
Pallabita Chowdhury Prashanth K B Nagesh Elham Hatami Santosh Wagh Nirnoy Dan Manish K Tripathi Sheema Khan Bilal B Hafeez Bernd Meibohm Subhash C Chauhan Meena Jaggi Murali M Yallapu

J Colloid Interface Sci 2019 Feb 22;535:133-148. Epub 2018 Sep 22.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00219797183114
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http://dx.doi.org/10.1016/j.jcis.2018.09.072DOI Listing
February 2019

Dynamic time-kill curve characterization of spectinamide antibiotics 1445 and 1599 for the treatment of tuberculosis.

Authors:
Pavan K Vaddady Ashit Trivedi Chetan Rathi Dora B Madhura Jiuyu Liu Richard E Lee Bernd Meibohm

Eur J Pharm Sci 2019 Jan 9;127:233-239. Epub 2018 Nov 9.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09280987183049
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http://dx.doi.org/10.1016/j.ejps.2018.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311108PMC
January 2019

Comparative pharmacokinetics of spectinamide 1599 after subcutaneous and intrapulmonary aerosol administration in mice.

Authors:
Chetan Rathi Pradeep B Lukka Santosh Wagh Richard E Lee Anne J Lenaerts Miriam Braunstein Anthony Hickey Mercedes Gonzalez-Juarrero Bernd Meibohm

Tuberculosis (Edinb) 2019 01 31;114:119-122. Epub 2018 Dec 31.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tube.2018.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362843PMC
January 2019

The Journey to AAPS 2020: a Reflection from Strategic Planning to PharmSci 360.

Authors:
Joseph W Polli Christopher R McCurdy Dale Eric Wurster Binodh S DeSilva Annette Bak Reina Bendayan Bernd Meibohm Allen C Templeton William Weiser

AAPS PharmSciTech 2018 Nov 3;19(8):3325-3327. Epub 2018 Nov 3.

, 3601 Sweeten Creek Road, Chapel Hill, NC, 27514, USA.

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http://dx.doi.org/10.1208/s12249-018-1200-3DOI Listing
November 2018

The Journey to AAPS 2020: a Reflection from Strategic Planning to PharmSci 360.

Authors:
Joseph W Polli Christopher R McCurdy Dale Eric Wurster Binodh S DeSilva Annette Bak Reina Bendayan Bernd Meibohm Allen C Templeton William Weiser

AAPS J 2018 11 3;21(1). Epub 2018 Nov 3.

, 3601 Sweeten Creek Road, Chapel Hill, USA.

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http://dx.doi.org/10.1208/s12248-018-0273-yDOI Listing
November 2018

Primary Lung Dendritic Cell Cultures to Assess Efficacy of Spectinamide-1599 Against Intracellular .

Authors:
Karen Santos Pradeep B Lukka Anne Grzegorzewicz Mary Jackson Ashit Trivedi Fernando Pavan Marlus Chorilli Miriam Braunstein Anthony Hickey Bernd Meibohm Mercedes Gonzalez-Juarrero

Front Microbiol 2018 21;9:1895. Epub 2018 Aug 21.

Mycobacteria Research Laboratories, Department of Microbiology, Immunology & Pathology, Colorado State University, Fort Collins, CO, United States.

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https://www.frontiersin.org/article/10.3389/fmicb.2018.01895
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http://dx.doi.org/10.3389/fmicb.2018.01895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110900PMC
August 2018

Pharmacometric Applications and Challenges in the Development of Therapeutic Antibodies in Immuno-Oncology.

Authors:
Lei Diao Bernd Meibohm

Curr Pharmacol Rep 2018 Aug 3;4(4):285-291. Epub 2018 May 3.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

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http://link.springer.com/10.1007/s40495-018-0142-5
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http://dx.doi.org/10.1007/s40495-018-0142-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181227PMC
August 2018

Sustained plasma hepcidin suppression and iron elevation by Anticalin-derived hepcidin antagonist in cynomolgus monkey.

Authors:
Andreas M Hohlbaum Hendrik Gille Stefan Trentmann Maria Kolodziejczyk Barbara Rattenstetter Coby M Laarakkers Galina Katzmann Hans Jürgen Christian Nicole Andersen Andrea Allersdorfer Shane A Olwill Bernd Meibohm Laurent P Audoly Dorine W Swinkels Rachel P L van Swelm

Br J Pharmacol 2018 04 23;175(7):1054-1065. Epub 2018 Feb 23.

Department of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1111/bph.14143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843705PMC
April 2018

Comparison of caffeine disposition following administration by oral solution (energy drink) and inspired powder (AeroShot) in human subjects.

Authors:
S Casey Laizure Bernd Meibohm Kembral Nelson Feng Chen Zhe-Yi Hu Robert B Parker

Br J Clin Pharmacol 2017 12 5;83(12):2687-2694. Epub 2017 Sep 5.

Department of Clinical Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

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http://doi.wiley.com/10.1111/bcp.13389
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http://dx.doi.org/10.1111/bcp.13389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698589PMC
December 2017

Influence of Ethanol on Darunavir Hepatic Clearance and Intracellular PK/PD in HIV-Infected Monocytes, and CYP3A4-Darunavir Interactions Using Inhibition and in Silico Binding Studies.

Authors:
Narasimha M Midde Yuqing Gong Theodore J Cory Junhao Li Bernd Meibohm Weihua Li Santosh Kumar

Pharm Res 2017 Sep 14;34(9):1925-1933. Epub 2017 Jun 14.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Ave, Rm 456, Memphis, TN, 38163, USA.

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http://link.springer.com/10.1007/s11095-017-2203-6
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http://dx.doi.org/10.1007/s11095-017-2203-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901969PMC
September 2017

Pharmacokinetics of Monoclonal Antibodies.

Authors:
Josiah T Ryman Bernd Meibohm

CPT Pharmacometrics Syst Pharmacol 2017 09 29;6(9):576-588. Epub 2017 Jul 29.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

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http://doi.wiley.com/10.1002/psp4.12224
Publisher Site
http://dx.doi.org/10.1002/psp4.12224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613179PMC
September 2017

Assessment of the Drug-Drug Interaction Potential Between Theacrine and Caffeine in Humans.

Authors:
Hui He Dejian Ma Laura Brooks Crone Matthew Butawan Bernd Meibohm Richard J Bloomer Charles R Yates

J Caffeine Res 2017 Sep;7(3):95-102

Department of Pharmaceutical Sciences, University of Tennessee College of Pharmacy, Memphis, Tennessee.

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http://dx.doi.org/10.1089/jcr.2017.0006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582588PMC
September 2017

Alterations in cellular pharmacokinetics and pharmacodynamics of elvitegravir in response to ethanol exposure in HIV-1 infected monocytic (U1) cells.

Authors:
Narasimha M Midde Namita Sinha Pradeep B Lukka Bernd Meibohm Santosh Kumar

PLoS One 2017 23;12(2):e0172628. Epub 2017 Feb 23.

Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis TN, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172628PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322882PMC
August 2017

Regulatory and Ethical Issues in Pediatric Clinical Research: Recommendations From a Panel Discussion.

Authors:
Nilima Kshirsagar Soumya Swaminathan Pramod Jog Samir Dalwai Roli Mathur Chandra Shekhar Bernd Meibohm Y K Gupta Nusrat Shafiq Gangadhar Sunkara V G Somani Prasad Kulkarni Brian Tseng Dhvani Mehta

J Clin Pharmacol 2017 08 17;57(8):943-946. Epub 2017 May 17.

Vidhi Centre for Legal Policy, New Delhi, India.

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http://dx.doi.org/10.1002/jcph.916DOI Listing
August 2017

Core Entrustable Professional Activities in Clinical Pharmacology for Entering Residency: Biologics.

Authors:
Vera S Donnenberg Maja Mandic John C Rhee Timothy F Burns Bernd Meibohm Joan M Korth-Bradley

J Clin Pharmacol 2017 08 14;57(8):947-955. Epub 2017 Jun 14.

The American College of Clinical Pharmacology, Rockville, MD, USA.

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http://dx.doi.org/10.1002/jcph.938DOI Listing
August 2017

Long Pulmonary Residence Time and Plasma Half-Life of Tiotropium: Implications for Pharmacokinetic Bioequivalence Studies.

Authors:
Ashish Sharma Benjamin Weber Bernd Meibohm

Clin Drug Investig 2017 Jul;37(7):705-707

College of Pharmacy, University of Tennessee, Memphis, USA.

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http://dx.doi.org/10.1007/s40261-017-0534-zDOI Listing
July 2017

A New Combination of a Pleuromutilin Derivative and Doxycycline for Treatment of Multidrug-Resistant Acinetobacter baumannii.

Authors:
Shajila Siricilla Katsuhiko Mitachi Junshu Yang Shakiba Eslamimehr Maddie R Lemieux Bernd Meibohm Yinduo Ji Michio Kurosu

J Med Chem 2017 04 22;60(7):2869-2878. Epub 2017 Mar 22.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center , 881 Madison Avenue, Memphis, Tennessee 38163, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469366PMC
April 2017

Immune Suppression During Preclinical Drug Development Mitigates Immunogenicity-Mediated Impact on Therapeutic Exposure.

Authors:
Jonathan Herskovitz Josiah Ryman Theingi Thway Stephanie Lee Lei Zhou Narendra Chirmule Bernd Meibohm Vibha Jawa

AAPS J 2017 03 9;19(2):447-455. Epub 2017 Jan 9.

The Department of Medical Sciences, Amgen Inc., One Amgen Center Dr, Thousand Oaks, California, 91320, USA.

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http://dx.doi.org/10.1208/s12248-016-0026-8DOI Listing
March 2017

Translational PK/PD of anti-infective therapeutics.

Authors:
Chetan Rathi Richard E Lee Bernd Meibohm

Drug Discov Today Technol 2016 Sep - Dec;21-22:41-49. Epub 2016 Oct 28.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ddtec.2016.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172400PMC
February 2017

Structure-Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions.

Authors:
Jiuyu Liu David F Bruhn Robin B Lee Zhong Zheng Tanja Janusic Dimitri Scherbakov Michael S Scherman Helena I Boshoff Sourav Das Rakesh Samanthi L Waidyarachchi Tiffany A Brewer Begoña Gracia Lei Yang John Bollinger Gregory T Robertson Bernd Meibohm Anne J Lenaerts Jose Ainsa Erik C Böttger Richard E Lee

ACS Infect Dis 2017 01 11;3(1):72-88. Epub 2016 Nov 11.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital , 262 Danny Thomas Place, MS#1000, Memphis, Tennessee 38105, United States.

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http://dx.doi.org/10.1021/acsinfecdis.6b00158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493200PMC
January 2017

Drug Development of Therapeutic Monoclonal Antibodies.

Authors:
Diane R Mould Bernd Meibohm

BioDrugs 2016 Aug;30(4):275-93

College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN, USA.

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http://dx.doi.org/10.1007/s40259-016-0181-6DOI Listing
August 2016

Effect of Ethanol on the Metabolic Characteristics of HIV-1 Integrase Inhibitor Elvitegravir and Elvitegravir/Cobicistat with CYP3A: An Analysis Using a Newly Developed LC-MS/MS Method.

Authors:
Narasimha M Midde Mohammad A Rahman Chetan Rathi Junhao Li Bernd Meibohm Weihua Li Santosh Kumar

PLoS One 2016 12;11(2):e0149225. Epub 2016 Feb 12.

Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0149225PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752462PMC
July 2016

Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver.

Authors:
Margaret M S Thomson Ronald N Hines Erin G Schuetz Bernd Meibohm

Drug Metab Dispos 2016 07 20;44(7):999-1004. Epub 2016 Apr 20.

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee (M.M.S.T., B.M.); Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin (R.N.H.); and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital Memphis, Tennessee (E.G.S.)

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http://dx.doi.org/10.1124/dmd.115.069252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931892PMC
July 2016

Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development.

Authors:
J Steven Leeder Bernd Meibohm

Drug Metab Dispos 2016 07;44(7):916-23

Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Department of Pediatrics, Children's Mercy Hospitals and Clinics, University of Missouri-Kansas City, Kansas City, Missouri (J.S.L.); and Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Sciences Center, Memphis, Tennessee (B.M.).

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http://dx.doi.org/10.1124/dmd.116.071159DOI Listing
July 2016

Tissue Penetration of a Novel Spectinamide Antibiotic for the Treatment of Tuberculosis.

Authors:
Dora Babu Madhura Ashit Trivedi Jiuyu Liu Vincent A Boyd Cynthia Jeffries Vivian Loveless Richard E Lee Bernd Meibohm

AAPS J 2016 05 16;18(3):788-91. Epub 2016 Mar 16.

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 881 Madison Ave, Suite 444, Memphis, Tennessee, 38163, USA.

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http://dx.doi.org/10.1208/s12248-016-9900-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256617PMC
May 2016

Urinary metabolites from mango (Mangifera indica L. cv. Keitt) galloyl derivatives and in vitro hydrolysis of gallotannins in physiological conditions.

Authors:
Ryan C Barnes Kimberly A Krenek Bernd Meibohm Susanne U Mertens-Talcott Stephen T Talcott

Mol Nutr Food Res 2016 Mar 2;60(3):542-50. Epub 2016 Feb 2.

Department of Nutrition and Food Science, Texas A&M University, College Station, TX, USA.

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http://dx.doi.org/10.1002/mnfr.201500706DOI Listing
March 2016

Pattern Recognition in Pharmacokinetic Data Analysis.

Authors:
Johan Gabrielsson Bernd Meibohm Daniel Weiner

AAPS J 2016 Jan 3;18(1):47-63. Epub 2015 Sep 3.

, 709 Cambridge Hall Loop, Apex, North Carolina, 27539, USA.

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http://dx.doi.org/10.1208/s12248-015-9817-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706292PMC
January 2016

Phase II Metabolic Pathways of Spectinamide Antitubercular Agents: A Comparative Study of the Reactivity of 4-Substituted Pyridines to Glutathione Conjugation.

Authors:
Dora B Madhura Juiyu Liu Bernd Meibohm Richard E Lee

Medchemcomm 2016 Jan 7;7(1):114-117. Epub 2015 Sep 7.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1039/C5MD00349KDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814158PMC
January 2016

Essential criteria for pharmacokinetic studies supporting bioequivalence of inhaled tiotropium bromide products.

Authors:
Ashish Sharma Benjamin Weber Martina Wein Christoph Hallmann Bernd Meibohm

Clin Pharmacol Drug Dev 2016 01 2;5(1):52-6. Epub 2015 Jun 2.

College of Pharmacy, University of Tennessee, Memphis, TN, USA.

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http://dx.doi.org/10.1002/cpdd.187DOI Listing
January 2016

Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function.

Authors:
Wenbo Tang Matthew Kowgier Daan W Loth María Soler Artigas Bonnie R Joubert Emily Hodge Sina A Gharib Albert V Smith Ingo Ruczinski Vilmundur Gudnason Rasika A Mathias Tamara B Harris Nadia N Hansel Lenore J Launer Kathleen C Barnes Joyanna G Hansen Eva Albrecht Melinda C Aldrich Michael Allerhand R Graham Barr Guy G Brusselle David J Couper Ivan Curjuric Gail Davies Ian J Deary Josée Dupuis Tove Fall Millennia Foy Nora Franceschini Wei Gao Sven Gläser Xiangjun Gu Dana B Hancock Joachim Heinrich Albert Hofman Medea Imboden Erik Ingelsson Alan James Stefan Karrasch Beate Koch Stephen B Kritchevsky Ashish Kumar Lies Lahousse Guo Li Lars Lind Cecilia Lindgren Yongmei Liu Kurt Lohman Thomas Lumley Wendy L McArdle Bernd Meibohm Andrew P Morris Alanna C Morrison Bill Musk Kari E North Lyle J Palmer Nicole M Probst-Hensch Bruce M Psaty Fernando Rivadeneira Jerome I Rotter Holger Schulz Lewis J Smith Akshay Sood John M Starr David P Strachan Alexander Teumer André G Uitterlinden Henry Völzke Arend Voorman Louise V Wain Martin T Wells Jemma B Wilk O Dale Williams Susan R Heckbert Bruno H Stricker Stephanie J London Myriam Fornage Martin D Tobin George T O'Connor Ian P Hall Patricia A Cassano

PLoS One 2014 1;9(7):e100776. Epub 2014 Jul 1.

Division of Nutritional Sciences, Cornell University, Ithaca, New York, United States of America; Department of Health Care Policy and Research, Division of Biostatistics and Epidemiology, Weill Cornell Medical College, New York, New York, United States of America.

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http://repub.eur.nl/pub/55346/journal.pone.0100776.pdf
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http://dx.plos.org/10.1371/journal.pone.0100776
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100776PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077649PMC
November 2015

In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics.

Authors:
David F Bruhn Michael S Scherman Jiuyu Liu Dimitri Scherbakov Bernd Meibohm Erik C Böttger Anne J Lenaerts Richard E Lee

Sci Rep 2015 Sep 14;5:13985. Epub 2015 Sep 14.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1038/srep13985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568539PMC
September 2015

Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist.

Authors:
Chaela Presley Ammaar Abidi Satyendra Suryawanshi Suni Mustafa Bernd Meibohm Bob M Moore

Pharmacol Res Perspect 2015 Aug 6;3(4):e00159. Epub 2015 Jul 6.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center Memphis, Tennessee.

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http://dx.doi.org/10.1002/prp2.159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506688PMC
August 2015

Tools for predicting the PK/PD of therapeutic proteins.

Authors:
Lei Diao Bernd Meibohm

Expert Opin Drug Metab Toxicol 2015 Jul 4;11(7):1115-25. Epub 2015 May 4.

Biogen Idec, Clinical Pharmacology and Pharmacometrics , Cambridge, MA , USA.

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http://dx.doi.org/10.1517/17425255.2015.1041917DOI Listing
July 2015

Effects of alcohol on human carboxylesterase drug metabolism.

Authors:
Robert B Parker Zhe-Yi Hu Bernd Meibohm S Casey Laizure

Clin Pharmacokinet 2015 Jun;54(6):627-38

Department of Clinical Pharmacy, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Room 346, Memphis, TN, 38163, USA,

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http://dx.doi.org/10.1007/s40262-014-0226-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450114PMC
June 2015

Aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections.

Authors:
David F Bruhn Samanthi L Waidyarachchi Dora B Madhura Dimitri Shcherbakov Zhong Zheng Jiuyu Liu Yasser M Abdelrahman Aman P Singh Stefan Duscha Chetan Rathi Robin B Lee Robert J Belland Bernd Meibohm Jason W Rosch Erik C Böttger Richard E Lee

Sci Transl Med 2015 May;7(288):288ra75

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1126/scitranslmed.3010572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641453PMC
May 2015

Ethanol lock therapy: a pilot infusion study in infants.

Authors:
Rebecca F Chhim Catherine M Crill Hailey K Collier Sandra R Arnold Massroor Pourcyrous Bernd Meibohm Michael Christensen

Ann Pharmacother 2015 Apr 28;49(4):431-6. Epub 2015 Jan 28.

Department of Clinical Pharmacy, The University of Tennessee Health Science Center, Memphis, TN, USA Le Bonheur Children's Hospital, Memphis, TN, USA Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, TN, USA.

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April 2015

Challenges and considerations for development of therapeutic proteins in pediatric patients.

Authors:
Yi Zhang Xiaohui Wei Gaurav Bajaj Jeffrey S Barrett Bernd Meibohm Amita Joshi Manish Gupta

J Clin Pharmacol 2015 Mar;55 Suppl 3:S103-15

Former employee of Clinical Pharmacology, Genentech, South San Francisco, USA; Oncology Clinical Pharmacology, Novartis, East Hanover, USA.

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March 2015

Clinical pharmacology of bispecific antibody constructs.

Authors:
Chetan Rathi Bernd Meibohm

J Clin Pharmacol 2015 Mar;55 Suppl 3:S21-8

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.

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http://dx.doi.org/10.1002/jcph.445DOI Listing
March 2015

Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis.

Authors:
Rakesh David F Bruhn Michael S Scherman Lisa K Woolhiser Dora B Madhura Marcus M Maddox Aman P Singh Robin B Lee Julian G Hurdle Michael R McNeil Anne J Lenaerts Bernd Meibohm Richard E Lee

PLoS One 2014 5;9(2):e87909. Epub 2014 Feb 5.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America ; Biomedical Sciences Program, Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914891PMC
November 2014

Protein engineering for improved pharmacologic characteristics of established monoclonal antibody-based therapeutics.

Authors:
Bernd Meibohm

Clin Pharmacokinet 2014 Oct;53(10):863-4

College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Rm. 444, Memphis, TN, 38163, USA,

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October 2014

The challenge of indication extrapolation for infliximab biosimilars.

Authors:
Brian G Feagan Denis Choquette Subrata Ghosh Dafna D Gladman Vincent Ho Bernd Meibohm Guangyong Zou Zhenhua Xu Gopi Shankar David C Sealey Anthony S Russell

Biologicals 2014 Jul 21;42(4):177-83. Epub 2014 Jun 21.

University of Alberta, Edmonton, AB, Canada.

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July 2014

Novel endogenous glycan therapy for retinal diseases: safety, in vitro stability, ocular pharmacokinetic modeling, and biodistribution.

Authors:
Shankar Swaminathan Huiling Li Mallika Palamoor Walter T Luchsinger de Obarrio Dorababu Madhura Bernd Meibohm Monica M Jablonski

AAPS J 2014 Mar 28;16(2):311-23. Epub 2014 Jan 28.

Department of Ophthalmology, Hamilton Eye Institute, The University of Tennessee Health Science Center, 930 Madison Avenue, Suite 731, Memphis, Tennessee, 38163, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933590PMC
March 2014

Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux.

Authors:
Richard E Lee Julian G Hurdle Jiuyu Liu David F Bruhn Tanja Matt Michael S Scherman Pavan K Vaddady Zhong Zheng Jianjun Qi Rashid Akbergenov Sourav Das Dora B Madhura Chetan Rathi Ashit Trivedi Cristina Villellas Robin B Lee Rakesh Samanthi L Waidyarachchi Dianqing Sun Michael R McNeil Jose A Ainsa Helena I Boshoff Mercedes Gonzalez-Juarrero Bernd Meibohm Erik C Böttger Anne J Lenaerts

Nat Med 2014 Feb 26;20(2):152-158. Epub 2014 Jan 26.

Mycobacterial Research Laboratories, Department of Microbiology, Colorado State University, Fort Collins, Colorado, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972818PMC
February 2014

Pharmacokinetics of intravenous amiodarone in children.

Authors:
Sergej Ramusovic Stephanie Läer Bernd Meibohm Florian B Lagler Thomas Paul

Arch Dis Child 2013 Dec 19;98(12):989-93. Epub 2013 Sep 19.

Department of Clinical Pharmacy and Pharmacotherapy, Heinrich-Heine-University, , Düsseldorf, Germany.

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December 2013

Genetic variation in antioxidant enzymes, cigarette smoking, and longitudinal change in lung function.

Authors:
Wenbo Tang Amy R Bentley Stephen B Kritchevsky Tamara B Harris Anne B Newman Douglas C Bauer Bernd Meibohm Patricia A Cassano

Free Radic Biol Med 2013 Oct 17;63:304-12. Epub 2013 May 17.

Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060265PMC
October 2013

Pharmacokinetics and pharmacokinetic-pharmacodynamic correlations of therapeutic peptides.

Authors:
Lei Diao Bernd Meibohm

Clin Pharmacokinet 2013 Oct;52(10):855-68

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Rm. 444, Memphis, TN, 38163, USA.

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October 2013

American Association of Pharmaceutical Scientists National Biotechnology Conference Short Course: Translational Challenges in Developing Antibody-Drug Conjugates: May 24, 2012, San Diego, CA.

Authors:
Karen Thudium Sanela Bilic Douglas Leipold William Mallet Surinder Kaur Bernd Meibohm Hans Erickson Jay Tibbitts Hong Zhao Manish Gupta

MAbs 2013 Jan-Feb;5(1):5-12. Epub 2012 Dec 19.

Novartis Pharmaceuticals, Clinical Pharmacology, Oncology Business Unit, Florham Park, NJ, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564886PMC
July 2013

Developing a gene expression model for predicting ventilator-associated pneumonia in trauma patients: a pilot study.

Authors:
Joseph M Swanson G Christopher Wood Lijing Xu Lisa E Tang Bernd Meibohm Ramin Homayouni Martin A Croce Timothy C Fabian

PLoS One 2012 15;7(8):e42065. Epub 2012 Aug 15.

Department of Clinical Pharmacy, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419717PMC
May 2013

Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.

Authors:
Dana B Hancock María Soler Artigas Sina A Gharib Amanda Henry Ani Manichaikul Adaikalavan Ramasamy Daan W Loth Medea Imboden Beate Koch Wendy L McArdle Albert V Smith Joanna Smolonska Akshay Sood Wenbo Tang Jemma B Wilk Guangju Zhai Jing Hua Zhao Hugues Aschard Kristin M Burkart Ivan Curjuric Mark Eijgelsheim Paul Elliott Xiangjun Gu Tamara B Harris Christer Janson Georg Homuth Pirro G Hysi Jason Z Liu Laura R Loehr Kurt Lohman Ruth J F Loos Alisa K Manning Kristin D Marciante Ma'en Obeidat Dirkje S Postma Melinda C Aldrich Guy G Brusselle Ting-hsu Chen Gudny Eiriksdottir Nora Franceschini Joachim Heinrich Jerome I Rotter Cisca Wijmenga O Dale Williams Amy R Bentley Albert Hofman Cathy C Laurie Thomas Lumley Alanna C Morrison Bonnie R Joubert Fernando Rivadeneira David J Couper Stephen B Kritchevsky Yongmei Liu Matthias Wjst Louise V Wain Judith M Vonk André G Uitterlinden Thierry Rochat Stephen S Rich Bruce M Psaty George T O'Connor Kari E North Daniel B Mirel Bernd Meibohm Lenore J Launer Kay-Tee Khaw Anna-Liisa Hartikainen Christopher J Hammond Sven Gläser Jonathan Marchini Peter Kraft Nicholas J Wareham Henry Völzke Bruno H C Stricker Timothy D Spector Nicole M Probst-Hensch Deborah Jarvis Marjo-Riitta Jarvelin Susan R Heckbert Vilmundur Gudnason H Marike Boezen R Graham Barr Patricia A Cassano David P Strachan Myriam Fornage Ian P Hall Josée Dupuis Martin D Tobin Stephanie J London

PLoS Genet 2012 20;8(12):e1003098. Epub 2012 Dec 20.

Behavioral Health Epidemiology Program, Research Triangle Institute International, Research Triangle Park, North Carolina, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527213PMC
May 2013

Strategic biomarkers for drug development in treating rare diseases and diseases in neonates and infants.

Authors:
Jane P F Bai Jeffrey S Barrett Gibert J Burckart Bernd Meibohm Hari Cheryl Sachs Lynne Yao

AAPS J 2013 Apr 19;15(2):447-54. Epub 2013 Jan 19.

Office of Clinical Pharmacology, Center for Drug Evaluation and Research, FDA, Silver Spring, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675740PMC
April 2013

Applications of pharmacometrics in the clinical development and pharmacotherapy of anti-infectives.

Authors:
Ashit Trivedi Richard E Lee Bernd Meibohm

Expert Rev Clin Pharmacol 2013 Mar;6(2):159-70

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.

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http://dx.doi.org/10.1586/ecp.13.6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809903PMC
March 2013

Simple and sensitive assay for quantification of oseltamivir and its active metabolite oseltamivir carboxylate in human plasma using high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry: improved applicability to pharmacokinetic study.

Authors:
Zhe-Yi Hu S Casey Laizure Bernd Meibohm Vanessa L Herring Robert B Parker

J Pharm Biomed Anal 2013 Jan 5;72:245-50. Epub 2012 Sep 5.

University of Tennessee Health Science Center, College of Pharmacy, Department of Clinical Pharmacy and Pharmaceutical Sciences, Memphis, TN 38163, USA.

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http://dx.doi.org/10.1016/j.jpba.2012.08.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496839PMC
January 2013

Genetic ancestry-smoking interactions and lung function in African Americans: a cohort study.

Authors:
Melinda C Aldrich Rajesh Kumar Laura A Colangelo L Keoki Williams Saunak Sen Stephen B Kritchevsky Bernd Meibohm Joshua Galanter Donglei Hu Christopher R Gignoux Yongmei Liu Tamara B Harris Elad Ziv Joseph Zmuda Melissa Garcia Tennille S Leak Marilyn G Foreman Lewis J Smith Myriam Fornage Kiang Liu Esteban G Burchard

PLoS One 2012 21;7(6):e39541. Epub 2012 Jun 21.

Division of Epidemiology, Department of Thoracic Surgery, Vanderbilt University, Nashville, Tennessee, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380861PMC
December 2012

Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.

Authors:
Jemma B Wilk Nick R G Shrine Laura R Loehr Jing Hua Zhao Ani Manichaikul Lorna M Lopez Albert Vernon Smith Susan R Heckbert Joanna Smolonska Wenbo Tang Daan W Loth Ivan Curjuric Jennie Hui Michael H Cho Jeanne C Latourelle Amanda P Henry Melinda Aldrich Per Bakke Terri H Beaty Amy R Bentley Ingrid B Borecki Guy G Brusselle Kristin M Burkart Ting-hsu Chen David Couper James D Crapo Gail Davies Josée Dupuis Nora Franceschini Amund Gulsvik Dana B Hancock Tamara B Harris Albert Hofman Medea Imboden Alan L James Kay-Tee Khaw Lies Lahousse Lenore J Launer Augusto Litonjua Yongmei Liu Kurt K Lohman David A Lomas Thomas Lumley Kristin D Marciante Wendy L McArdle Bernd Meibohm Alanna C Morrison Arthur W Musk Richard H Myers Kari E North Dirkje S Postma Bruce M Psaty Stephen S Rich Fernando Rivadeneira Thierry Rochat Jerome I Rotter María Soler Artigas John M Starr André G Uitterlinden Nicholas J Wareham Cisca Wijmenga Pieter Zanen Michael A Province Edwin K Silverman Ian J Deary Lyle J Palmer Patricia A Cassano Vilmundur Gudnason R Graham Barr Ruth J F Loos David P Strachan Stephanie J London H Marike Boezen Nicole Probst-Hensch Sina A Gharib Ian P Hall George T O'Connor Martin D Tobin Bruno H Stricker

Am J Respir Crit Care Med 2012 Oct 26;186(7):622-32. Epub 2012 Jul 26.

Division of Aging, Brigham and Women's Hospital and Harvard Medical School, 1620 Tremont Street, Boston, MA 02120, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480517PMC
October 2012

Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties.

Authors:
Rakesh David Bruhn Dora B Madhura Marcus Maddox Robin B Lee Ashit Trivedi Lei Yang Michael S Scherman Janet C Gilliland Veronica Gruppo Michael R McNeil Anne J Lenaerts Bernd Meibohm Richard E Lee

Bioorg Med Chem 2012 Oct 28;20(20):6063-72. Epub 2012 Aug 28.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1016/j.bmc.2012.08.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582038PMC
October 2012

The influence of abdominal visceral fat on inflammatory pathways and mortality risk in obstructive lung disease.

Authors:
Bram van den Borst Harry R Gosker Annemarie Koster Binbing Yu Stephen B Kritchevsky Yongmei Liu Bernd Meibohm Thomas B Rice Michael Shlipak Sachin Yende Tamara B Harris Annemie M W J Schols

Am J Clin Nutr 2012 Sep 18;96(3):516-26. Epub 2012 Jul 18.

NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417214PMC
September 2012

Cognitive Impairment and Medication Complexity in Community-Living Older Adults: The Health, Aging and Body Composition Study.

Authors:
David Sh Lee Nathalie de Rekeneire Joseph T Hanlon Thomas M Gill Douglas C Bauer Bernd Meibohm Tamara B Harris Sean M Jeffery

J Pharm Technol 2012 Jul;28(4):156-162

School of Pharmacy, University of Connecticut, Storrs, CT.

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http://dx.doi.org/10.1177/875512251202800405DOI Listing
July 2012

Immunogenicity to therapeutic proteins: impact on PK/PD and efficacy.

Authors:
Narendra Chirmule Vibha Jawa Bernd Meibohm

AAPS J 2012 Jun 10;14(2):296-302. Epub 2012 Mar 10.

Clinical Immunology, Amgen, Thousand Oaks, California, USA.

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http://dx.doi.org/10.1208/s12248-012-9340-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326159PMC
June 2012

Genetic variation in antioxidant enzymes and lung function.

Authors:
Amy R Bentley Stephen B Kritchevsky Tamara B Harris Anne B Newman Douglas C Bauer Bernd Meibohm Andrew G Clark Patricia A Cassano

Free Radic Biol Med 2012 May 1;52(9):1577-83. Epub 2012 Mar 1.

Center for Research in Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2012.02.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390784PMC
May 2012

Evaluation of vancomycin dosing regimens in preterm and term neonates using Monte Carlo simulations.

Authors:
Nitin Mehrotra Lisa Tang Stephanie J Phelps Bernd Meibohm

Pharmacotherapy 2012 May 9;32(5):408-19. Epub 2012 Apr 9.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.

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http://dx.doi.org/10.1002/j.1875-9114.2012.01029.xDOI Listing
May 2012

Study design and simulation approach.

Authors:
Stephanie Läer Bernd Meibohm

Handb Exp Pharmacol 2011 ;205:125-48

Department of Clinical Pharmacy and Pharmacotherapy, Heinrich-Heine-University of Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany.

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February 2012

Characterizing the impact of renal impairment on the clinical pharmacology of biologics.

Authors:
Bernd Meibohm Honghui Zhou

J Clin Pharmacol 2012 Jan;52(1 Suppl):54S-62S

College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, TN 38163, USA.

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http://dx.doi.org/10.1177/0091270011413894DOI Listing
January 2012

Comparative performance of cell life span and cell transit models for describing erythropoietic drug effects.

Authors:
Nageshwar R Budha Andreas Kovar Bernd Meibohm

AAPS J 2011 Dec 18;13(4):650-61. Epub 2011 Oct 18.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, USA.

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http://dx.doi.org/10.1208/s12248-011-9302-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231865PMC
December 2011

Population pharmacokinetic/pharmacodynamic analyses as the basis for dosing of therapeutic monoclonal antibodies.

Authors:
Bernd Meibohm

Clin Pharmacokinet 2011 Dec;50(12):823-4

College of Pharmacy, University of Tennessee Health Science Center, Memphis, USA.

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http://dx.doi.org/10.2165/11597950-000000000-00000DOI Listing
December 2011

Is age-related decline in lean mass and physical function accelerated by obstructive lung disease or smoking?

Authors:
Bram van den Borst Annemarie Koster Binbing Yu Harry R Gosker Bernd Meibohm Douglas C Bauer Stephen B Kritchevsky Yongmei Liu Anne B Newman Tamara B Harris Annemie M W J Schols

Thorax 2011 Nov 1;66(11):961-9. Epub 2011 Jul 1.

Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center+, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285455PMC
November 2011

Pharmacokinetics of ponazuril after oral administration to healthy llamas (Lama glama).

Authors:
Maria E Prado Josiah T Ryman Melanie J Boileau Tomas Martin-Jimenez Bernd Meibohm

Am J Vet Res 2011 Oct;72(10):1386-9

Department of Animal Science, Institute of Agriculture, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.

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October 2011

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

Authors:
María Soler Artigas Daan W Loth Louise V Wain Sina A Gharib Ma'en Obeidat Wenbo Tang Guangju Zhai Jing Hua Zhao Albert Vernon Smith Jennifer E Huffman Eva Albrecht Catherine M Jackson David M Evans Gemma Cadby Myriam Fornage Ani Manichaikul Lorna M Lopez Toby Johnson Melinda C Aldrich Thor Aspelund Inês Barroso Harry Campbell Patricia A Cassano David J Couper Gudny Eiriksdottir Nora Franceschini Melissa Garcia Christian Gieger Gauti Kjartan Gislason Ivica Grkovic Christopher J Hammond Dana B Hancock Tamara B Harris Adaikalavan Ramasamy Susan R Heckbert Markku Heliövaara Georg Homuth Pirro G Hysi Alan L James Stipan Jankovic Bonnie R Joubert Stefan Karrasch Norman Klopp Beate Koch Stephen B Kritchevsky Lenore J Launer Yongmei Liu Laura R Loehr Kurt Lohman Ruth J F Loos Thomas Lumley Khalid A Al Balushi Wei Q Ang R Graham Barr John Beilby John D Blakey Mladen Boban Vesna Boraska Jonas Brisman John R Britton Guy G Brusselle Cyrus Cooper Ivan Curjuric Santosh Dahgam Ian J Deary Shah Ebrahim Mark Eijgelsheim Clyde Francks Darya Gaysina Raquel Granell Xiangjun Gu John L Hankinson Rebecca Hardy Sarah E Harris John Henderson Amanda Henry Aroon D Hingorani Albert Hofman Patrick G Holt Jennie Hui Michael L Hunter Medea Imboden Karen A Jameson Shona M Kerr Ivana Kolcic Florian Kronenberg Jason Z Liu Jonathan Marchini Tricia McKeever Andrew D Morris Anna-Carin Olin David J Porteous Dirkje S Postma Stephen S Rich Susan M Ring Fernando Rivadeneira Thierry Rochat Avan Aihie Sayer Ian Sayers Peter D Sly George Davey Smith Akshay Sood John M Starr André G Uitterlinden Judith M Vonk S Goya Wannamethee Peter H Whincup Cisca Wijmenga O Dale Williams Andrew Wong Massimo Mangino Kristin D Marciante Wendy L McArdle Bernd Meibohm Alanna C Morrison Kari E North Ernst Omenaas Lyle J Palmer Kirsi H Pietiläinen Isabelle Pin Ozren Pola Sbreve Ek Anneli Pouta Bruce M Psaty Anna-Liisa Hartikainen Taina Rantanen Samuli Ripatti Jerome I Rotter Igor Rudan Alicja R Rudnicka Holger Schulz So-Youn Shin Tim D Spector Ida Surakka Veronique Vitart Henry Völzke Nicholas J Wareham Nicole M Warrington H-Erich Wichmann Sarah H Wild Jemma B Wilk Matthias Wjst Alan F Wright Lina Zgaga Tatijana Zemunik Craig E Pennell Fredrik Nyberg Diana Kuh John W Holloway H Marike Boezen Debbie A Lawlor Richard W Morris Nicole Probst-Hensch Jaakko Kaprio James F Wilson Caroline Hayward Mika Kähönen Joachim Heinrich Arthur W Musk Deborah L Jarvis Sven Gläser Marjo-Riitta Järvelin Bruno H Ch Stricker Paul Elliott George T O'Connor David P Strachan Stephanie J London Ian P Hall Vilmundur Gudnason Martin D Tobin

Nat Genet 2011 Sep 25;43(11):1082-90. Epub 2011 Sep 25.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267376PMC
September 2011

Translational biomarkers: from preclinical to clinical a report of 2009 AAPS/ACCP Biomarker Workshop.

Authors:
Jane P F Bai Robert Bell ShaAvhree Buckman Gilbert J Burckart Hans-Georg Eichler Kenneth C Fang Federico M Goodsaid William J Jusko Lawrence L Lesko Bernd Meibohm Scott D Patterson Oscar Puig Jeffrey B Smerage Barbara J Snider John A Wagner Jingsong Wang Marc K Walton Russell Weiner

AAPS J 2011 Jun 30;13(2):274-83. Epub 2011 Mar 30.

Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085704PMC
June 2011

Pharmacokinetics of a combination of Δ9-tetrahydro-cannabinol and celecoxib in a porcine model of hemorrhagic shock.

Authors:
Pavan K Vaddady Nitin Mehrotra Xiaofeng Zhang Charles R Yates Bob M Moore Bernd Meibohm

Biopharm Drug Dispos 2011 Mar 23;32(2):89-98. Epub 2010 Dec 23.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

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http://dx.doi.org/10.1002/bdd.740DOI Listing
March 2011

Population pharmacokinetics of therapeutic monoclonal antibodies.

Authors:
Nathanael L Dirks Bernd Meibohm

Clin Pharmacokinet 2010 Oct;49(10):633-59

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.

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http://dx.doi.org/10.2165/11535960-000000000-00000DOI Listing
October 2010

Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents.

Authors:
Jianjun Chen Zhao Wang Chien-Ming Li Yan Lu Pavan K Vaddady Bernd Meibohm James T Dalton Duane D Miller Wei Li

J Med Chem 2010 Oct;53(20):7414-27

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.

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http://pubs.acs.org/doi/abs/10.1021/jm100884b
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964152PMC
October 2010

Pharmacometrics as a discipline is entering the "industrialization" phase: standards, automation, knowledge sharing, and training are critical for future success.

Authors:
Klaus Romero Brian Corrigan Christoffer W Tornoe Jogarao V Gobburu Meindert Danhof William R Gillespie Marc R Gastonguay Bernd Meibohm Hartmut Derendorf

J Clin Pharmacol 2010 Sep;50(9 Suppl):9S-19S

Coalition Against Major Diseases, Critical Path Institute, Tucson, AZ 85718, USA.

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http://doi.wiley.com/10.1177/0091270010377788
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September 2010

In vitro pharmacokinetic/pharmacodynamic models in anti-infective drug development: focus on TB.

Authors:
Pavan K Vaddady Richard E Lee Bernd Meibohm

Future Med Chem 2010 Aug;2(8):1355-69

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 874 Union Avenue, Suite 5p, TN 38163, USA.

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http://dx.doi.org/10.4155/fmc.10.224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042695PMC
August 2010

Genetic ancestry in lung-function predictions.

Authors:
Rajesh Kumar Max A Seibold Melinda C Aldrich L Keoki Williams Alex P Reiner Laura Colangelo Joshua Galanter Christopher Gignoux Donglei Hu Saunak Sen Shweta Choudhry Edward L Peterson Jose Rodriguez-Santana William Rodriguez-Cintron Michael A Nalls Tennille S Leak Ellen O'Meara Bernd Meibohm Stephen B Kritchevsky Rongling Li Tamara B Harris Deborah A Nickerson Myriam Fornage Paul Enright Elad Ziv Lewis J Smith Kiang Liu Esteban González Burchard

N Engl J Med 2010 Jul 7;363(4):321-30. Epub 2010 Jul 7.

Division of Allergy and Immunology, Children's Memorial Hospital, 2300 Children's Plaza, Box 60, Chicago IL 60614, USA.

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http://dx.doi.org/10.1056/NEJMoa0907897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922981PMC
July 2010

The current role of model-based drug development.

Authors:
Satyendra Suryawanshi Liping Zhang Marc Pfister Bernd Meibohm

Expert Opin Drug Discov 2010 Apr;5(4):311-21

University of Tennessee Health Science Center, College of Pharmacy, Department of Pharmaceutical Sciences, 874 Union Avenue, Suite 5p, Memphis, TN 38163, USA +1 901 448 1206 ; +1 901 448 6940 ;

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http://dx.doi.org/10.1517/17460441003713470DOI Listing
April 2010

Predictors of mortality in elderly subjects with obstructive airway disease: the PILE score.

Authors:
Nitin Mehrotra Amado X Freire Douglas C Bauer Tamara B Harris Anne B Newman Stephen B Kritchevsky Bernd Meibohm

Ann Epidemiol 2010 Mar;20(3):223-32

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, College of Pharmacy, 874 Union Ave., Memphis, TN 38163, USA.

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http://dx.doi.org/10.1016/j.annepidem.2009.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827353PMC
March 2010

Toward optimal treatment in women: the effect of sex on metoprolol-diphenhydramine interaction.

Authors:
Ashish Sharma Philippe Pibarot Sylvie Pilote Jean G Dumesnil Marie Arsenault Pierre Maxime Bélanger Bernd Meibohm Bettina A Hamelin

J Clin Pharmacol 2010 Feb 30;50(2):214-25. Epub 2009 Nov 30.

Quebec Heart and Lung Institute, Ste-Foy, Quebec, Canada.

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http://dx.doi.org/10.1177/0091270009340417DOI Listing
February 2010

A simple in vitro PK/PD model system to determine time-kill curves of drugs against Mycobacteria.

Authors:
Nageshwar R Budha Robin B Lee Julian G Hurdle Richard E Lee Bernd Meibohm

Tuberculosis (Edinb) 2009 Sep 11;89(5):378-85. Epub 2009 Sep 11.

Department of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, 874 Union Avenue, Suite 5p, Memphis, TN 38163, USA.

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http://dx.doi.org/10.1016/j.tube.2009.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783979PMC
September 2009

The in silico child: using simulation to guide pediatric drug development and manage pediatric pharmacotherapy.

Authors:
Stephanie Läer Jeffrey S Barrett Bernd Meibohm

J Clin Pharmacol 2009 Aug 16;49(8):889-904. Epub 2009 Jun 16.

Department of Clinical Pharmacy and Pharmacotherapy, Heinrich-Heine-University of Düsseldorf, 40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1177/0091270009337513DOI Listing
August 2009

A tandem mass spectrometry assay for the simultaneous determination of acetaminophen, caffeine, phenytoin, ranitidine, and theophylline in small volume pediatric plasma specimens.

Authors:
Yi Zhang Nitin Mehrotra Nageshwar R Budha Michael L Christensen Bernd Meibohm

Clin Chim Acta 2008 Dec 3;398(1-2):105-12. Epub 2008 Sep 3.

Department of Pharmaceutical Sciences; University of Tennessee Health Science Center, Memphis, TN 38163, United States.

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http://dx.doi.org/10.1016/j.cca.2008.08.023DOI Listing
December 2008

Concepts and challenges in quantitative pharmacology and model-based drug development.

Authors:
Liping Zhang Marc Pfister Bernd Meibohm

AAPS J 2008 Dec 12;10(4):552-9. Epub 2008 Nov 12.

Bristol Myers Squibb Research and Development, Princeton, New Jersey, USA.

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http://dx.doi.org/10.1208/s12248-008-9062-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628212PMC
December 2008

A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents.

Authors:
Julian G Hurdle Robin B Lee Nageshwar R Budha Elizabeth I Carson Jianjun Qi Michael S Scherman Sang Hyun Cho Michael R McNeil Anne J Lenaerts Scott G Franzblau Bernd Meibohm Richard E Lee

J Antimicrob Chemother 2008 Nov 7;62(5):1037-45. Epub 2008 Aug 7.

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.

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http://www.jac.oxfordjournals.org/cgi/doi/10.1093/jac/dkn307
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http://dx.doi.org/10.1093/jac/dkn307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566515PMC
November 2008

Pharmacokinetically-guided lead optimization of nitrofuranylamide anti-tuberculosis agents.

Authors:
Nageshwar R Budha Nitin Mehrotra Rajendra Tangallapally Rakesh Jianjun Qi Antwan J Daniels Richard E Lee Bernd Meibohm

AAPS J 2008 14;10(1):157-65. Epub 2008 Mar 14.

Department of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, 874 Union Avenue, Suite 5p, Memphis, Tennessee 38163, USA.

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http://dx.doi.org/10.1208/s12248-008-9017-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751462PMC
September 2008

Pharmacokinetics of anthocyanins and antioxidant effects after the consumption of anthocyanin-rich acai juice and pulp (Euterpe oleracea Mart.) in human healthy volunteers.

Authors:
Susanne U Mertens-Talcott Jolian Rios Petra Jilma-Stohlawetz Lisbeth A Pacheco-Palencia Bernd Meibohm Stephen T Talcott Hartmut Derendorf

J Agric Food Chem 2008 Sep 12;56(17):7796-802. Epub 2008 Aug 12.

Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas 77843, USA.

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http://dx.doi.org/10.1021/jf8007037DOI Listing
September 2008

Biopharmaceutics, pharmacokinetics and pharmacodynamics of antituberculosis drugs.

Authors:
Nageshwar R Budha Richard E Lee Bernd Meibohm

Curr Med Chem 2008 ;15(8):809-25

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38162, USA.

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http://dx.doi.org/10.2174/092986708783955509DOI Listing
June 2008

Population pharmacokinetics and dose simulation of carvedilol in paediatric patients with congestive heart failure.

Authors:
Stefanie Albers Bernd Meibohm Thomas S Mir Stephanie Läer

Br J Clin Pharmacol 2008 Apr 8;65(4):511-22. Epub 2007 Nov 8.

Clinical Pharmacology and Pharmacotherapy, University of Düsseldorf, Germany.

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http://dx.doi.org/10.1111/j.1365-2125.2007.03046.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291380PMC
April 2008

Population pharmacokinetics of cetuximab in patients with squamous cell carcinoma of the head and neck.

Authors:
Nathanael L Dirks Arno Nolting Andreas Kovar Bernd Meibohm

J Clin Pharmacol 2008 Mar 24;48(3):267-78. Epub 2008 Jan 24.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA.

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http://dx.doi.org/10.1177/0091270007313393DOI Listing
March 2008

Discovery of novel isoxazolines as anti-tuberculosis agents.

Authors:
Rajendra P Tangallapally Dianqing Sun Rakesh Nageshwar Budha Robin E B Lee Anne J M Lenaerts Bernd Meibohm Richard E Lee

Bioorg Med Chem Lett 2007 Dec 15;17(23):6638-42. Epub 2007 Sep 15.

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

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http://dx.doi.org/10.1016/j.bmcl.2007.09.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140235PMC
December 2007

G2677T and C3435T genotype and haplotype are associated with hepatic ABCB1 (MDR1) expression.

Authors:
Pengfei Song Jatinder K Lamba Lijun Zhang Erin Schuetz Nikhil Shukla Bernd Meibohm Charles R Yates

J Clin Pharmacol 2006 Mar;46(3):373-9

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.

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http://dx.doi.org/10.1177/0091270005284387DOI Listing
March 2006

Single- and multiple-dose pharmacokinetics of pioglitazone in adolescents with type 2 diabetes.

Authors:
Michael L Christensen Bernd Meibohm Edmund V Capparelli Pedro Velasquez-Mieyer George A Burghen William V Tamborlane

J Clin Pharmacol 2005 Oct;45(10):1137-44

University of Tennessee, 50 North Dunlap, Room 306, Memphis, TN 38103, USA.

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http://dx.doi.org/10.1177/0091270005279578DOI Listing
October 2005

Development of a safe and effective pediatric dosing regimen for sotalol based on population pharmacokinetics and pharmacodynamics in children with supraventricular tachycardia.

Authors:
Stephanie Läer Jan-Peer Elshoff Bernd Meibohm Jochen Weil Thomas S Mir Wenhui Zhang Martin Hulpke-Wette

J Am Coll Cardiol 2005 Oct;46(7):1322-30

Department of Clinical Pharmacy and Therapeutics, University Düsseldorf, Düsseldorf, Germany.

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http://dx.doi.org/10.1016/j.jacc.2005.06.061DOI Listing
October 2005

Population pharmacokinetic studies in pediatrics: issues in design and analysis.

Authors:
Bernd Meibohm Stephanie Läer John C Panetta Jeffrey S Barrett

AAPS J 2005 Oct 5;7(2):E475-87. Epub 2005 Oct 5.

Department of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.

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http://dx.doi.org/10.1208/aapsj070248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750985PMC
October 2005

The clinical pharmacokinetics of phosphodiesterase-5 inhibitors for erectile dysfunction.

Authors:
Manish Gupta Andreas Kovar Bernd Meibohm

J Clin Pharmacol 2005 Sep;45(9):987-1003

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 874 Union Avenue, Suite 5p, Memphis, TN 38163, USA.

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http://doi.wiley.com/10.1177/0091270005276847
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http://dx.doi.org/10.1177/0091270005276847DOI Listing
September 2005

LC/MS/MS in drug development: targeting the brain.

Authors:
Pengfei Song Bernd Meibohm Charles R Yates

Biotechniques 2005 Jun;Suppl:19-23

The University of Tennessee Health Science Center, Memphis, TN 38163, USA.

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http://dx.doi.org/10.2144/05386su03DOI Listing
June 2005