Bernd Meibohm

Bernd Meibohm

UNVERIFIED PROFILE

Are you Bernd Meibohm?   Register this Author

Register author
Bernd Meibohm

Bernd Meibohm

Publications by authors named "Bernd Meibohm"

Are you Bernd Meibohm?   Register this Author

100Publications

2167Reads

44Profile Views

Immunogenicity in Clinical Practice and Drug Development: When is it Significant?

Clin Transl Sci 2019 Nov 25. Epub 2019 Nov 25.

Clinical Pharmacology & Pharmacometrics, Bristol-Myers Squibb, Princeton, New Jersey, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cts.12717DOI Listing
November 2019

Cross-Linked Polyphenol-Based Drug Nano-Self-Assemblies Engineered to Blockade Prostate Cancer Senescence.

ACS Appl Mater Interfaces 2019 Oct 8;11(42):38537-38554. Epub 2019 Oct 8.

Department of Microbiology and Immunology , School of Medicine, University of Texas Rio Grande Valley , McAllen , Texas 78504 , United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.9b14738DOI Listing
October 2019

Sterilization of Mycobacterium tuberculosis infected samples using methanol preserves anti-tuberculosis drugs for subsequent pharmacological testing studies.

Tuberculosis (Edinb) 2019 07 6;117:52-55. Epub 2019 Jun 6.

Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, 80523, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tube.2019.06.002DOI Listing
July 2019

Tannic acid-inspired paclitaxel nanoparticles for enhanced anticancer effects in breast cancer cells.

J Colloid Interface Sci 2019 Feb 22;535:133-148. Epub 2018 Sep 22.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00219797183114
Publisher Site
http://dx.doi.org/10.1016/j.jcis.2018.09.072DOI Listing
February 2019

Dynamic time-kill curve characterization of spectinamide antibiotics 1445 and 1599 for the treatment of tuberculosis.

Eur J Pharm Sci 2019 Jan 9;127:233-239. Epub 2018 Nov 9.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09280987183049
Publisher Site
http://dx.doi.org/10.1016/j.ejps.2018.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311108PMC
January 2019

Comparative pharmacokinetics of spectinamide 1599 after subcutaneous and intrapulmonary aerosol administration in mice.

Tuberculosis (Edinb) 2019 01 31;114:119-122. Epub 2018 Dec 31.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tube.2018.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362843PMC
January 2019

The Journey to AAPS 2020: a Reflection from Strategic Planning to PharmSci 360.

AAPS PharmSciTech 2018 Nov 3;19(8):3325-3327. Epub 2018 Nov 3.

, 3601 Sweeten Creek Road, Chapel Hill, NC, 27514, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1208/s12249-018-1200-3DOI Listing
November 2018

Primary Lung Dendritic Cell Cultures to Assess Efficacy of Spectinamide-1599 Against Intracellular .

Front Microbiol 2018 21;9:1895. Epub 2018 Aug 21.

Mycobacteria Research Laboratories, Department of Microbiology, Immunology & Pathology, Colorado State University, Fort Collins, CO, United States.

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fmicb.2018.01895
Publisher Site
http://dx.doi.org/10.3389/fmicb.2018.01895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110900PMC
August 2018

Pharmacometric Applications and Challenges in the Development of Therapeutic Antibodies in Immuno-Oncology.

Curr Pharmacol Rep 2018 Aug 3;4(4):285-291. Epub 2018 May 3.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s40495-018-0142-5
Publisher Site
http://dx.doi.org/10.1007/s40495-018-0142-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181227PMC
August 2018

Comparison of caffeine disposition following administration by oral solution (energy drink) and inspired powder (AeroShot) in human subjects.

Br J Clin Pharmacol 2017 12 5;83(12):2687-2694. Epub 2017 Sep 5.

Department of Clinical Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/bcp.13389
Publisher Site
http://dx.doi.org/10.1111/bcp.13389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698589PMC
December 2017

Influence of Ethanol on Darunavir Hepatic Clearance and Intracellular PK/PD in HIV-Infected Monocytes, and CYP3A4-Darunavir Interactions Using Inhibition and in Silico Binding Studies.

Pharm Res 2017 Sep 14;34(9):1925-1933. Epub 2017 Jun 14.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Ave, Rm 456, Memphis, TN, 38163, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11095-017-2203-6
Publisher Site
http://dx.doi.org/10.1007/s11095-017-2203-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901969PMC
September 2017

Pharmacokinetics of Monoclonal Antibodies.

CPT Pharmacometrics Syst Pharmacol 2017 09 29;6(9):576-588. Epub 2017 Jul 29.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/psp4.12224
Publisher Site
http://dx.doi.org/10.1002/psp4.12224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613179PMC
September 2017

Assessment of the Drug-Drug Interaction Potential Between Theacrine and Caffeine in Humans.

J Caffeine Res 2017 Sep;7(3):95-102

Department of Pharmaceutical Sciences, University of Tennessee College of Pharmacy, Memphis, Tennessee.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/jcr.2017.0006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582588PMC
September 2017

Alterations in cellular pharmacokinetics and pharmacodynamics of elvitegravir in response to ethanol exposure in HIV-1 infected monocytic (U1) cells.

PLoS One 2017 23;12(2):e0172628. Epub 2017 Feb 23.

Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis TN, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172628PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322882PMC
August 2017

Core Entrustable Professional Activities in Clinical Pharmacology for Entering Residency: Biologics.

J Clin Pharmacol 2017 08 14;57(8):947-955. Epub 2017 Jun 14.

The American College of Clinical Pharmacology, Rockville, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcph.938DOI Listing
August 2017

Long Pulmonary Residence Time and Plasma Half-Life of Tiotropium: Implications for Pharmacokinetic Bioequivalence Studies.

Clin Drug Investig 2017 Jul;37(7):705-707

College of Pharmacy, University of Tennessee, Memphis, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40261-017-0534-zDOI Listing
July 2017

A New Combination of a Pleuromutilin Derivative and Doxycycline for Treatment of Multidrug-Resistant Acinetobacter baumannii.

J Med Chem 2017 04 22;60(7):2869-2878. Epub 2017 Mar 22.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center , 881 Madison Avenue, Memphis, Tennessee 38163, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.6b01805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469366PMC
April 2017

Immune Suppression During Preclinical Drug Development Mitigates Immunogenicity-Mediated Impact on Therapeutic Exposure.

AAPS J 2017 03 9;19(2):447-455. Epub 2017 Jan 9.

The Department of Medical Sciences, Amgen Inc., One Amgen Center Dr, Thousand Oaks, California, 91320, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1208/s12248-016-0026-8DOI Listing
March 2017

Translational PK/PD of anti-infective therapeutics.

Drug Discov Today Technol 2016 Sep - Dec;21-22:41-49. Epub 2016 Oct 28.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ddtec.2016.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172400PMC
February 2017

Drug Development of Therapeutic Monoclonal Antibodies.

BioDrugs 2016 Aug;30(4):275-93

College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40259-016-0181-6DOI Listing
August 2016

Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver.

Drug Metab Dispos 2016 07 20;44(7):999-1004. Epub 2016 Apr 20.

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee (M.M.S.T., B.M.); Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin (R.N.H.); and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital Memphis, Tennessee (E.G.S.)

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.115.069252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931892PMC
July 2016

Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development.

Drug Metab Dispos 2016 07;44(7):916-23

Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Department of Pediatrics, Children's Mercy Hospitals and Clinics, University of Missouri-Kansas City, Kansas City, Missouri (J.S.L.); and Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Sciences Center, Memphis, Tennessee (B.M.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.116.071159DOI Listing
July 2016

Tissue Penetration of a Novel Spectinamide Antibiotic for the Treatment of Tuberculosis.

AAPS J 2016 05 16;18(3):788-91. Epub 2016 Mar 16.

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 881 Madison Ave, Suite 444, Memphis, Tennessee, 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1208/s12248-016-9900-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256617PMC
May 2016

Urinary metabolites from mango (Mangifera indica L. cv. Keitt) galloyl derivatives and in vitro hydrolysis of gallotannins in physiological conditions.

Mol Nutr Food Res 2016 Mar 2;60(3):542-50. Epub 2016 Feb 2.

Department of Nutrition and Food Science, Texas A&M University, College Station, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mnfr.201500706DOI Listing
March 2016

Pattern Recognition in Pharmacokinetic Data Analysis.

AAPS J 2016 Jan 3;18(1):47-63. Epub 2015 Sep 3.

, 709 Cambridge Hall Loop, Apex, North Carolina, 27539, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1208/s12248-015-9817-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706292PMC
January 2016

Phase II Metabolic Pathways of Spectinamide Antitubercular Agents: A Comparative Study of the Reactivity of 4-Substituted Pyridines to Glutathione Conjugation.

Medchemcomm 2016 Jan 7;7(1):114-117. Epub 2015 Sep 7.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/C5MD00349KDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814158PMC
January 2016

Essential criteria for pharmacokinetic studies supporting bioequivalence of inhaled tiotropium bromide products.

Clin Pharmacol Drug Dev 2016 01 2;5(1):52-6. Epub 2015 Jun 2.

College of Pharmacy, University of Tennessee, Memphis, TN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpdd.187DOI Listing
January 2016

Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function.

PLoS One 2014 1;9(7):e100776. Epub 2014 Jul 1.

Division of Nutritional Sciences, Cornell University, Ithaca, New York, United States of America; Department of Health Care Policy and Research, Division of Biostatistics and Epidemiology, Weill Cornell Medical College, New York, New York, United States of America.

View Article

Download full-text PDF

Source
http://repub.eur.nl/pub/55346/journal.pone.0100776.pdf
Web Search
http://dx.plos.org/10.1371/journal.pone.0100776
Publisher Site
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100776PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077649PMC
November 2015

In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics.

Sci Rep 2015 Sep 14;5:13985. Epub 2015 Sep 14.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep13985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568539PMC
September 2015

Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist.

Pharmacol Res Perspect 2015 Aug 6;3(4):e00159. Epub 2015 Jul 6.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center Memphis, Tennessee.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/prp2.159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506688PMC
August 2015

Tools for predicting the PK/PD of therapeutic proteins.

Expert Opin Drug Metab Toxicol 2015 Jul 4;11(7):1115-25. Epub 2015 May 4.

Biogen Idec, Clinical Pharmacology and Pharmacometrics , Cambridge, MA , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1517/17425255.2015.1041917DOI Listing
July 2015

Effects of alcohol on human carboxylesterase drug metabolism.

Clin Pharmacokinet 2015 Jun;54(6):627-38

Department of Clinical Pharmacy, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Room 346, Memphis, TN, 38163, USA,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40262-014-0226-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450114PMC
June 2015

Ethanol lock therapy: a pilot infusion study in infants.

Ann Pharmacother 2015 Apr 28;49(4):431-6. Epub 2015 Jan 28.

Department of Clinical Pharmacy, The University of Tennessee Health Science Center, Memphis, TN, USA Le Bonheur Children's Hospital, Memphis, TN, USA Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, TN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1060028015569881DOI Listing
April 2015

Challenges and considerations for development of therapeutic proteins in pediatric patients.

J Clin Pharmacol 2015 Mar;55 Suppl 3:S103-15

Former employee of Clinical Pharmacology, Genentech, South San Francisco, USA; Oncology Clinical Pharmacology, Novartis, East Hanover, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcph.382DOI Listing
March 2015

Clinical pharmacology of bispecific antibody constructs.

J Clin Pharmacol 2015 Mar;55 Suppl 3:S21-8

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcph.445DOI Listing
March 2015

Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis.

PLoS One 2014 5;9(2):e87909. Epub 2014 Feb 5.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America ; Biomedical Sciences Program, Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087909PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914891PMC
November 2014

Protein engineering for improved pharmacologic characteristics of established monoclonal antibody-based therapeutics.

Authors:
Bernd Meibohm

Clin Pharmacokinet 2014 Oct;53(10):863-4

College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Rm. 444, Memphis, TN, 38163, USA,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40262-014-0186-6DOI Listing
October 2014

Novel endogenous glycan therapy for retinal diseases: safety, in vitro stability, ocular pharmacokinetic modeling, and biodistribution.

AAPS J 2014 Mar 28;16(2):311-23. Epub 2014 Jan 28.

Department of Ophthalmology, Hamilton Eye Institute, The University of Tennessee Health Science Center, 930 Madison Avenue, Suite 731, Memphis, Tennessee, 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1208/s12248-014-9563-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933590PMC
March 2014

Pharmacokinetics of intravenous amiodarone in children.

Arch Dis Child 2013 Dec 19;98(12):989-93. Epub 2013 Sep 19.

Department of Clinical Pharmacy and Pharmacotherapy, Heinrich-Heine-University, , Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/archdischild-2013-304483DOI Listing
December 2013

Pharmacokinetics and pharmacokinetic-pharmacodynamic correlations of therapeutic peptides.

Clin Pharmacokinet 2013 Oct;52(10):855-68

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Rm. 444, Memphis, TN, 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40262-013-0079-0DOI Listing
October 2013

Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.

PLoS Genet 2012 20;8(12):e1003098. Epub 2012 Dec 20.

Behavioral Health Epidemiology Program, Research Triangle Institute International, Research Triangle Park, North Carolina, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1003098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527213PMC
May 2013

Strategic biomarkers for drug development in treating rare diseases and diseases in neonates and infants.

AAPS J 2013 Apr 19;15(2):447-54. Epub 2013 Jan 19.

Office of Clinical Pharmacology, Center for Drug Evaluation and Research, FDA, Silver Spring, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1208/s12248-013-9452-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675740PMC
April 2013

Applications of pharmacometrics in the clinical development and pharmacotherapy of anti-infectives.

Expert Rev Clin Pharmacol 2013 Mar;6(2):159-70

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/ecp.13.6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809903PMC
March 2013

Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.

Am J Respir Crit Care Med 2012 Oct 26;186(7):622-32. Epub 2012 Jul 26.

Division of Aging, Brigham and Women's Hospital and Harvard Medical School, 1620 Tremont Street, Boston, MA 02120, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201202-0366OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480517PMC
October 2012

Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties.

Bioorg Med Chem 2012 Oct 28;20(20):6063-72. Epub 2012 Aug 28.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2012.08.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582038PMC
October 2012

The influence of abdominal visceral fat on inflammatory pathways and mortality risk in obstructive lung disease.

Am J Clin Nutr 2012 Sep 18;96(3):516-26. Epub 2012 Jul 18.

NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.

View Article

Download full-text PDF

Source
https://academic.oup.com/ajcn/article/96/3/516/4576789
Publisher Site
http://dx.doi.org/10.3945/ajcn.112.040774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417214PMC
September 2012

Immunogenicity to therapeutic proteins: impact on PK/PD and efficacy.

AAPS J 2012 Jun 10;14(2):296-302. Epub 2012 Mar 10.

Clinical Immunology, Amgen, Thousand Oaks, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1208/s12248-012-9340-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326159PMC
June 2012

Genetic variation in antioxidant enzymes and lung function.

Free Radic Biol Med 2012 May 1;52(9):1577-83. Epub 2012 Mar 1.

Center for Research in Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S089158491200128
Publisher Site
http://dx.doi.org/10.1016/j.freeradbiomed.2012.02.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390784PMC
May 2012

Evaluation of vancomycin dosing regimens in preterm and term neonates using Monte Carlo simulations.

Pharmacotherapy 2012 May 9;32(5):408-19. Epub 2012 Apr 9.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/j.1875-9114.2012.01029.xDOI Listing
May 2012

Study design and simulation approach.

Handb Exp Pharmacol 2011 ;205:125-48

Department of Clinical Pharmacy and Pharmacotherapy, Heinrich-Heine-University of Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-642-20195-0_6DOI Listing
February 2012

Characterizing the impact of renal impairment on the clinical pharmacology of biologics.

J Clin Pharmacol 2012 Jan;52(1 Suppl):54S-62S

College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, TN 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0091270011413894DOI Listing
January 2012

Comparative performance of cell life span and cell transit models for describing erythropoietic drug effects.

AAPS J 2011 Dec 18;13(4):650-61. Epub 2011 Oct 18.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1208/s12248-011-9302-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231865PMC
December 2011

Population pharmacokinetic/pharmacodynamic analyses as the basis for dosing of therapeutic monoclonal antibodies.

Authors:
Bernd Meibohm

Clin Pharmacokinet 2011 Dec;50(12):823-4

College of Pharmacy, University of Tennessee Health Science Center, Memphis, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2165/11597950-000000000-00000DOI Listing
December 2011

Is age-related decline in lean mass and physical function accelerated by obstructive lung disease or smoking?

Thorax 2011 Nov 1;66(11):961-9. Epub 2011 Jul 1.

Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center+, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

View Article

Download full-text PDF

Source
http://thorax.bmj.com/cgi/doi/10.1136/thoraxjnl-2011-200010
Publisher Site
http://dx.doi.org/10.1136/thoraxjnl-2011-200010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285455PMC
November 2011

Pharmacokinetics of ponazuril after oral administration to healthy llamas (Lama glama).

Am J Vet Res 2011 Oct;72(10):1386-9

Department of Animal Science, Institute of Agriculture, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2460/ajvr.72.10.1386DOI Listing
October 2011

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

Authors:
María Soler Artigas Daan W Loth Louise V Wain Sina A Gharib Ma'en Obeidat Wenbo Tang Guangju Zhai Jing Hua Zhao Albert Vernon Smith Jennifer E Huffman Eva Albrecht Catherine M Jackson David M Evans Gemma Cadby Myriam Fornage Ani Manichaikul Lorna M Lopez Toby Johnson Melinda C Aldrich Thor Aspelund Inês Barroso Harry Campbell Patricia A Cassano David J Couper Gudny Eiriksdottir Nora Franceschini Melissa Garcia Christian Gieger Gauti Kjartan Gislason Ivica Grkovic Christopher J Hammond Dana B Hancock Tamara B Harris Adaikalavan Ramasamy Susan R Heckbert Markku Heliövaara Georg Homuth Pirro G Hysi Alan L James Stipan Jankovic Bonnie R Joubert Stefan Karrasch Norman Klopp Beate Koch Stephen B Kritchevsky Lenore J Launer Yongmei Liu Laura R Loehr Kurt Lohman Ruth J F Loos Thomas Lumley Khalid A Al Balushi Wei Q Ang R Graham Barr John Beilby John D Blakey Mladen Boban Vesna Boraska Jonas Brisman John R Britton Guy G Brusselle Cyrus Cooper Ivan Curjuric Santosh Dahgam Ian J Deary Shah Ebrahim Mark Eijgelsheim Clyde Francks Darya Gaysina Raquel Granell Xiangjun Gu John L Hankinson Rebecca Hardy Sarah E Harris John Henderson Amanda Henry Aroon D Hingorani Albert Hofman Patrick G Holt Jennie Hui Michael L Hunter Medea Imboden Karen A Jameson Shona M Kerr Ivana Kolcic Florian Kronenberg Jason Z Liu Jonathan Marchini Tricia McKeever Andrew D Morris Anna-Carin Olin David J Porteous Dirkje S Postma Stephen S Rich Susan M Ring Fernando Rivadeneira Thierry Rochat Avan Aihie Sayer Ian Sayers Peter D Sly George Davey Smith Akshay Sood John M Starr André G Uitterlinden Judith M Vonk S Goya Wannamethee Peter H Whincup Cisca Wijmenga O Dale Williams Andrew Wong Massimo Mangino Kristin D Marciante Wendy L McArdle Bernd Meibohm Alanna C Morrison Kari E North Ernst Omenaas Lyle J Palmer Kirsi H Pietiläinen Isabelle Pin Ozren Pola Sbreve Ek Anneli Pouta Bruce M Psaty Anna-Liisa Hartikainen Taina Rantanen Samuli Ripatti Jerome I Rotter Igor Rudan Alicja R Rudnicka Holger Schulz So-Youn Shin Tim D Spector Ida Surakka Veronique Vitart Henry Völzke Nicholas J Wareham Nicole M Warrington H-Erich Wichmann Sarah H Wild Jemma B Wilk Matthias Wjst Alan F Wright Lina Zgaga Tatijana Zemunik Craig E Pennell Fredrik Nyberg Diana Kuh John W Holloway H Marike Boezen Debbie A Lawlor Richard W Morris Nicole Probst-Hensch Jaakko Kaprio James F Wilson Caroline Hayward Mika Kähönen Joachim Heinrich Arthur W Musk Deborah L Jarvis Sven Gläser Marjo-Riitta Järvelin Bruno H Ch Stricker Paul Elliott George T O'Connor David P Strachan Stephanie J London Ian P Hall Vilmundur Gudnason Martin D Tobin

Nat Genet 2011 Sep 25;43(11):1082-90. Epub 2011 Sep 25.

Department of Health Sciences, University of Leicester, Leicester, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267376PMC
September 2011

Pharmacokinetics of a combination of Δ9-tetrahydro-cannabinol and celecoxib in a porcine model of hemorrhagic shock.

Biopharm Drug Dispos 2011 Mar 23;32(2):89-98. Epub 2010 Dec 23.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bdd.740DOI Listing
March 2011

Population pharmacokinetics of therapeutic monoclonal antibodies.

Clin Pharmacokinet 2010 Oct;49(10):633-59

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2165/11535960-000000000-00000DOI Listing
October 2010

Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents.

J Med Chem 2010 Oct;53(20):7414-27

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/jm100884b
Publisher Site
http://dx.doi.org/10.1021/jm100884bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964152PMC
October 2010

In vitro pharmacokinetic/pharmacodynamic models in anti-infective drug development: focus on TB.

Future Med Chem 2010 Aug;2(8):1355-69

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 874 Union Avenue, Suite 5p, TN 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4155/fmc.10.224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042695PMC
August 2010

The current role of model-based drug development.

Expert Opin Drug Discov 2010 Apr;5(4):311-21

University of Tennessee Health Science Center, College of Pharmacy, Department of Pharmaceutical Sciences, 874 Union Avenue, Suite 5p, Memphis, TN 38163, USA +1 901 448 1206 ; +1 901 448 6940 ;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1517/17460441003713470DOI Listing
April 2010

Predictors of mortality in elderly subjects with obstructive airway disease: the PILE score.

Ann Epidemiol 2010 Mar;20(3):223-32

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, College of Pharmacy, 874 Union Ave., Memphis, TN 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.annepidem.2009.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827353PMC
March 2010

Toward optimal treatment in women: the effect of sex on metoprolol-diphenhydramine interaction.

J Clin Pharmacol 2010 Feb 30;50(2):214-25. Epub 2009 Nov 30.

Quebec Heart and Lung Institute, Ste-Foy, Quebec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0091270009340417DOI Listing
February 2010

A simple in vitro PK/PD model system to determine time-kill curves of drugs against Mycobacteria.

Tuberculosis (Edinb) 2009 Sep 11;89(5):378-85. Epub 2009 Sep 11.

Department of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, 874 Union Avenue, Suite 5p, Memphis, TN 38163, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S147297920900079
Publisher Site
http://dx.doi.org/10.1016/j.tube.2009.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783979PMC
September 2009

The in silico child: using simulation to guide pediatric drug development and manage pediatric pharmacotherapy.

J Clin Pharmacol 2009 Aug 16;49(8):889-904. Epub 2009 Jun 16.

Department of Clinical Pharmacy and Pharmacotherapy, Heinrich-Heine-University of Düsseldorf, 40225 Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0091270009337513DOI Listing
August 2009

A tandem mass spectrometry assay for the simultaneous determination of acetaminophen, caffeine, phenytoin, ranitidine, and theophylline in small volume pediatric plasma specimens.

Clin Chim Acta 2008 Dec 3;398(1-2):105-12. Epub 2008 Sep 3.

Department of Pharmaceutical Sciences; University of Tennessee Health Science Center, Memphis, TN 38163, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cca.2008.08.023DOI Listing
December 2008

Concepts and challenges in quantitative pharmacology and model-based drug development.

AAPS J 2008 Dec 12;10(4):552-9. Epub 2008 Nov 12.

Bristol Myers Squibb Research and Development, Princeton, New Jersey, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1208/s12248-008-9062-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628212PMC
December 2008

Pharmacokinetically-guided lead optimization of nitrofuranylamide anti-tuberculosis agents.

AAPS J 2008 14;10(1):157-65. Epub 2008 Mar 14.

Department of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, 874 Union Avenue, Suite 5p, Memphis, Tennessee 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1208/s12248-008-9017-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751462PMC
September 2008

Pharmacokinetics of anthocyanins and antioxidant effects after the consumption of anthocyanin-rich acai juice and pulp (Euterpe oleracea Mart.) in human healthy volunteers.

J Agric Food Chem 2008 Sep 12;56(17):7796-802. Epub 2008 Aug 12.

Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas 77843, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jf8007037DOI Listing
September 2008

Biopharmaceutics, pharmacokinetics and pharmacodynamics of antituberculosis drugs.

Curr Med Chem 2008 ;15(8):809-25

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38162, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/092986708783955509DOI Listing
June 2008

Population pharmacokinetics and dose simulation of carvedilol in paediatric patients with congestive heart failure.

Br J Clin Pharmacol 2008 Apr 8;65(4):511-22. Epub 2007 Nov 8.

Clinical Pharmacology and Pharmacotherapy, University of Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2125.2007.03046.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291380PMC
April 2008

Population pharmacokinetics of cetuximab in patients with squamous cell carcinoma of the head and neck.

J Clin Pharmacol 2008 Mar 24;48(3):267-78. Epub 2008 Jan 24.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0091270007313393DOI Listing
March 2008

Discovery of novel isoxazolines as anti-tuberculosis agents.

Bioorg Med Chem Lett 2007 Dec 15;17(23):6638-42. Epub 2007 Sep 15.

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2007.09.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140235PMC
December 2007

G2677T and C3435T genotype and haplotype are associated with hepatic ABCB1 (MDR1) expression.

J Clin Pharmacol 2006 Mar;46(3):373-9

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0091270005284387DOI Listing
March 2006

Single- and multiple-dose pharmacokinetics of pioglitazone in adolescents with type 2 diabetes.

J Clin Pharmacol 2005 Oct;45(10):1137-44

University of Tennessee, 50 North Dunlap, Room 306, Memphis, TN 38103, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0091270005279578DOI Listing
October 2005

Population pharmacokinetic studies in pediatrics: issues in design and analysis.

AAPS J 2005 Oct 5;7(2):E475-87. Epub 2005 Oct 5.

Department of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1208/aapsj070248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750985PMC
October 2005

The clinical pharmacokinetics of phosphodiesterase-5 inhibitors for erectile dysfunction.

J Clin Pharmacol 2005 Sep;45(9):987-1003

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 874 Union Avenue, Suite 5p, Memphis, TN 38163, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1177/0091270005276847
Publisher Site
http://dx.doi.org/10.1177/0091270005276847DOI Listing
September 2005

LC/MS/MS in drug development: targeting the brain.

Biotechniques 2005 Jun;Suppl:19-23

The University of Tennessee Health Science Center, Memphis, TN 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2144/05386su03DOI Listing
June 2005