Bernd Kuhn

Bernd Kuhn

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Bernd Kuhn

Bernd Kuhn

Publications by authors named "Bernd Kuhn"

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85Publications

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Simultaneous dendritic voltage and calcium imaging and somatic recording from Purkinje neurons in awake mice.

Nat Commun 2018 Aug 23;9(1):3388. Epub 2018 Aug 23.

Optical Neuroimaging Unit, Okinawa Institute of Science and Technology Graduate University (OIST), 1919-1 Tancha, Onna-son, Okinawa, 904-0495, Japan.

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August 2018

Efficient Industrial Synthesis of the MDM2 Antagonist Idasanutlin via a Cu(I)-catalyzed [3+2] Asymmetric Cycloaddition.

Chimia (Aarau) 2018 Aug;72(7):492-500

Process Chemistry and Catalysis Small Molecule Technical Development F. Hoffmann-La Roche, CH-4070 Basel.

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August 2018

Motion-corrected multiparametric renal arterial spin labelling at 3 T: reproducibility and effect of vasodilator challenge.

Eur Radiol 2018 Jul 10. Epub 2018 Jul 10.

Medical Research Council (MRC), London Institute of Medical Sciences (LMS), Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.

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July 2018

Microstructure evolution and dislocation behaviour in high chromium, fully ferritic steels strengthened by intermetallic Laves phases.

Micron 2018 May 23;108:11-18. Epub 2018 Feb 23.

Forschungszentrum Jülich GmbH, Institute for Energy and Climate Research, Microstructure and Properties of Materials (IEK-2), 52428 Jülich, Germany.

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May 2018

Ligand channel in pharmacologically stabilized rhodopsin.

Proc Natl Acad Sci U S A 2018 04 19;115(14):3640-3645. Epub 2018 Mar 19.

Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland;

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April 2018

2 H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design.

J Med Chem 2018 Apr 6;61(8):3370-3388. Epub 2018 Apr 6.

Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel , F. Hoffmann-La Roche Ltd. , Grenzacherstrasse 124 , 4070 Basel , Switzerland.

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April 2018

Building Bridges through Science.

Authors:
Thomas Lissek Michelle Adams John Adelman Ehud Ahissar Mohammed Akaaboune Huda Akil Mustafa al'Absi Fazal Arain Juan Carlos Arango-Lasprilla Deniz Atasoy Jesus Avila Ashraf Badawi Hilmar Bading Abdul Mannan Baig Jimena Baleriola Carlos Belmonte Ilaria Bertocchi Heinrich Betz Colin Blakemore Olaf Blanke Philipp Boehm-Sturm Tobias Bonhoeffer Paolo Bonifazi Nils Brose Patrizia Campolongo Tansu Celikel Cathy C Chang Ta-Yuan Chang Ami Citri Hollis T Cline Jesus M Cortes Kathleen Cullen Kellie Dean José M Delgado-Garcia Mathieu Desroches John F Disterhoft John E Dowling Andreas Draguhn Sherif F El-Khamisy Abdeljabbar El Manira S Ather Enam Juan M Encinas Asier Erramuzpe José A Esteban Isabel Fariñas Edmond Fischer Izumi Fukunaga Iñigo Gabilondo Detlev Ganten Albert Gidon Juan Carlos Gomez-Esteban Paul Greengard Valery Grinevich Agnés Gruart Roger Guillemin Ahmad R Hariri Bassem Hassan Michael Häusser Yasunori Hayashi Natasha K Hussain Adnan Abdul Jabbar Mohamed Jaber Reinhardt Jahn Essam Mohammed Janahi Mohamed Kabbaj Helmut Kettenmann Merel Kindt Shira Knafo Georg Köhr Shoji Komai Harm Krugers Bernd Kuhn Nouria Lakhdar Ghazal Matthew E Larkum Mickey London Beat Lutz Carlos Matute Luis Martinez-Millan Mouna Maroun James McGaugh Ahmed A Moustafa Anwar Nasim Klaus-Armin Nave Erwin Neher Karoly Nikolich Tiago Outeiro Lucy M Palmer Olga Penagarikano Isabel Perez-Otano Donald W Pfaff Bruno Poucet Atta-Ur Rahman Pedro Ramos-Cabrer Ali Rashidy-Pour Richard J Roberts Serafim Rodrigues Joshua R Sanes Andreas T Schaefer Menahem Segal Idan Segev Saad Shafqat Nikhat Ahmed Siddiqui Hermona Soreq Eduardo Soriano-García Rainer Spanagel Rolf Sprengel Greg Stuart Thomas C Südhof Jan Tønnesen Mario Treviño Basim M Uthman J Craig Venter Alexei Verkhratsky Craig Weiss Torsten N Wiesel Emre Yaksi Ofer Yizhar Larry J Young Paul Young Nasser H Zawia José L Zugaza Mazahir T Hasan

Neuron 2017 Nov;96(4):730-735

Achucarro Basque Center for Neuroscience, 48940 Leioa, Spain. Electronic address:

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November 2017

Identification, size classification and evolution of Laves phase precipitates in high chromium, fully ferritic steels.

Micron 2017 Oct 24;101:221-231. Epub 2017 Jul 24.

Forschungszentrum Jülich GmbH, Institute for Energy and Climate Research, Microstructure and Properties of Materials (IEK-2), Jülich, 52428, Germany.

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October 2017

Substituent Effects in Parallel-Displaced π-π Stacking Interactions: Distance Matters.

Angew Chem Int Ed Engl 2017 Sep 11;56(37):11252-11257. Epub 2017 May 11.

Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, 8093, Zürich, Switzerland.

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September 2017

Identification of New ATG4B Inhibitors Based on a Novel High-Throughput Screening Platform.

SLAS Discov 2017 Apr 10;22(4):338-347. Epub 2016 Jul 10.

1 Roche Pharma Research and Early Development, Roche Innovation Center Shanghai, Shanghai, China.

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April 2017

Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors.

J Med Chem 2017 Mar 13;60(6):2485-2497. Epub 2017 Mar 13.

Roche Pharmaceutical Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. , Grenzacherstrasse 124, 4070 Basel, Switzerland.

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March 2017

Neural substrate of dynamic Bayesian inference in the cerebral cortex.

Nat Neurosci 2016 12 19;19(12):1682-1689. Epub 2016 Sep 19.

Neural Computation Unit, Okinawa Institute of Science and Technology Graduate University, Tancha, Onna-son, Kunigami, Okinawa, Japan.

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December 2016

Structural and Conformational Aspects of Equatorial and Axial Trifluoromethyl, Difluoromethyl, and Monofluoromethyl Groups.

Chemistry 2016 Nov 12;22(47):16920-16928. Epub 2016 Oct 12.

ETH Zürich, Laboratorium für Organische Chemie, Vladimir-Prelog-Weg 3, 8093, Zürich, Switzerland.

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November 2016

Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors.

ACS Med Chem Lett 2016 Aug 25;7(8):802-6. Epub 2016 Jun 25.

Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Shanghai , 720 Cailun Road, Shanghai 201203, China.

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August 2016

Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2).

Org Biomol Chem 2016 Jul 1;14(25):5922-7. Epub 2016 Jun 1.

Medicinal Chemistry, Roche Pharmaceutical Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, CH-4070 Basel, Switzerland.

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July 2016

Interactive and Versatile Navigation of Structural Databases.

J Med Chem 2016 05 8;59(9):4257-66. Epub 2016 Jan 8.

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. , Grenzacherstrasse 124, CH-4070 Basel, Switzerland.

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May 2016

A Real-World Perspective on Molecular Design.

J Med Chem 2016 05 24;59(9):4087-102. Epub 2016 Feb 24.

Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. , Grenzacherstrasse 124, 4070 Basel, Switzerland.

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May 2016

Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB Mimic.

Chemistry 2016 Jan 18;22(1):211-21. Epub 2015 Nov 18.

Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, 8093 Zürich (Switzerland), Fax: (+41) 44-632-11-09.

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January 2016

Intravoxel incoherent motion MRI for liver fibrosis assessment: a pilot study.

Acta Radiol 2015 Dec 20;56(12):1428-36. Epub 2014 Nov 20.

Siemens Healthcare Korea, Seoul, Republic of Korea.

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December 2015

Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases.

Chimia (Aarau) 2015 ;69(7-8):407-13

Roche Pharmaceutical Research and Early Development (pRED), Roche Innovation Center Basel, Medicinal Chemistry, 124 Grenzacherstrasse, B 92 / 4.92, CH-4070 Basel, Switzerland.

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December 2015

Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery.

J Med Chem 2015 Nov 17;58(22):9041-60. Epub 2015 Nov 17.

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche AG , Grenzacherstrasse 124, CH-4070 Basel, Switzerland.

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November 2015

Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases.

Chimia (Aarau) 2015 Aug;69(7):407-413

Roche Pharmaceutical Research and Early Development (pRED), Roche Innovation Center Basel, Medicinal Chemistry, 124 Grenzacherstrasse, B 92 / 4.92, CH-4070 Basel, Switzerland.

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August 2015

Characterization of Laves phase in Crofer 22 H stainless steel.

Micron 2015 Jul 27;74:59-64. Epub 2015 Apr 27.

Department of Chemical and Materials Engineering, National University of Kaohsiung, Kaohsiung City 811, Taiwan.

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July 2015

Rebek imide platforms as model systems for the investigation of weak intermolecular interactions.

Chemistry 2015 Jun 5;21(23):8455-63. Epub 2015 May 5.

Laboratorium für Organische Chemie, ETH Zürich, Hönggerberg, HCI, 8093 Zürich (Switzerland), Fax: (+41) 44-632-1109.

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June 2015

Intravoxel incoherent motion diffusion-weighted MR imaging of the liver: effect of triggering methods on regional variability and measurement repeatability of quantitative parameters.

Radiology 2015 Feb 17;274(2):405-15. Epub 2014 Sep 17.

From the Department of Radiology and Research Institute of Radiology (Y.L., S.S.L., N.K., E.K., Y.J.K., S.H.P., S.Y.K., M.G.L.) and Department of Clinical Epidemiology and Biostatistics (S.C.Y.), University of Ulsan College of Medicine, Asan Medical Center, 86 Asanbyeongwon-Gil, Songpa-Gu, Seoul 138-736, South Korea; Siemens AG, Healthcare, Oncology Applications Development, Erlangen, Germany (B.K.); and Siemens Healthcare Korea, Seoul, South Korea (I.S.K.).

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February 2015

Chronic cranial window with access port for repeated cellular manipulations, drug application, and electrophysiology.

Front Cell Neurosci 2014 11;8:379. Epub 2014 Nov 11.

Optical Neuroimaging Unit, Okinawa Institute of Science and Technology Graduate University Onna-son, Okinawa, Japan.

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November 2014

Dendritic diameters affect the spatial variability of intracellular calcium dynamics in computer models.

Front Cell Neurosci 2014 23;8:168. Epub 2014 Jul 23.

Theoretical Neurobiology and Neuroengineering, University of Antwerp Wilrijk, Belgium ; Computational Neuroscience Unit, Okinawa Institute of Science and Technology Onna-Son, Okinawa, Japan.

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August 2014

NMDA spike/plateau potentials in dendrites of thalamocortical neurons.

J Neurosci 2014 Aug;34(33):10892-905

Institute of Basic Medical Sciences, University of Oslo, N-0317 Oslo, Norway.

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August 2014

The structure of human α-2,6-sialyltransferase reveals the binding mode of complex glycans.

Acta Crystallogr D Biol Crystallogr 2013 Sep 17;69(Pt 9):1826-38. Epub 2013 Aug 17.

pRED Pharma Research and Early Development, Discovery Technologies, F. Hoffmann-La Roche AG, Grenzacher Strasse 124, 4070 Basel, Switzerland.

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September 2013

Efficient stacking on protein amide fragments.

ChemMedChem 2013 Mar 25;8(3):397-404. Epub 2013 Jan 25.

Laboratorium für Organische Chemie, ETH Zürich, Hönggerberg, HCI, 8093 Zürich, Switzerland.

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March 2013

An amplified promoter system for targeted expression of calcium indicator proteins in the cerebellar cortex.

Front Neural Circuits 2012 31;6:49. Epub 2012 Jul 31.

Princeton Neuroscience Institute, Princeton University Princeton, NJ, USA.

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October 2012

Optical pH detection within a protein crystal.

J Phys Chem B 2012 Aug 13;116(33):9873-81. Epub 2012 Aug 13.

Peter Grünberg Institute, Research Center Jülich, 52425 Jülich, Germany.

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August 2012

Comparative molecular profiling of the PPARα/γ activator aleglitazar: PPAR selectivity, activity and interaction with cofactors.

ChemMedChem 2012 Jun 4;7(6):1101-11. Epub 2012 Apr 4.

Discovery Technologies, F. Hoffmann-La Roche AG, Grenzacherstrasse 124, Basel 4070, Switzerland.

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June 2012

Rationalizing tight ligand binding through cooperative interaction networks.

J Chem Inf Model 2011 Dec 9;51(12):3180-98. Epub 2011 Dec 9.

Discovery Chemistry, F. Hoffmann-La Roche AG, CH-4070 Basel, Switzerland.

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December 2011

Cerebellar craniotomy for in vivo calcium imaging of astrocytes.

Cold Spring Harb Protoc 2011 Oct 1;2011(10):1224-7. Epub 2011 Oct 1.

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October 2011

Preferential loading of bergmann glia with synthetic acetoxymethyl calcium dyes.

Cold Spring Harb Protoc 2011 Oct 1;2011(10):1228-31. Epub 2011 Oct 1.

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October 2011

New Insights on the mechanism of PPAR-targeted drugs.

ChemMedChem 2010 Dec;5(12):1973-6

F. Hoffmann-La Roche Ltd., Basel, Switzerland.

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December 2010

Recent developments in the understanding of astrocyte function in the cerebellum in vivo.

Cerebellum 2010 Sep;9(3):264-71

Department of Molecular Biology and Princeton Neuroscience Institute, Lewis Thomas Laboratory, Washington Road, Princeton, New Jersey 08544, USA.

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September 2010

A medicinal chemist's guide to molecular interactions.

J Med Chem 2010 Jul;53(14):5061-84

Discovery Chemistry, F. Hoffmann-La Roche AG, CH-4070 Basel, Switzerland.

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July 2010

Calcium imaging of neuronal circuits in vivo using a circuit-tracing pseudorabies virus.

Cold Spring Harb Protoc 2010 Apr;2010(4):pdb.prot5410

Department of Molecular Biology and Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.

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April 2010

Intramolecular hydrogen bonding in medicinal chemistry.

J Med Chem 2010 Mar;53(6):2601-11

Discovery Chemistry, F Hoffmann-La Roche AG, CH-4070 Basel, Switzerland.

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March 2010

Fluorescence-based monitoring of in vivo neural activity using a circuit-tracing pseudorabies virus.

PLoS One 2009 Sep 9;4(9):e6923. Epub 2009 Sep 9.

Department of Molecular Biology, Neuroscience Institute, Princeton University, Princeton, New Jersey, United States of America.

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September 2009

Mutagenesis and molecular modeling of the orthosteric binding site of the mGlu2 receptor determining interactions of the group II receptor antagonist (3)H-HYDIA.

ChemMedChem 2009 Jul;4(7):1086-94

Pharmaceutical Division, Discovery Research CNS and Medicinal Chemistry, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland.

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July 2009

Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist.

Bioorg Med Chem Lett 2009 May 9;19(9):2595-8. Epub 2009 Mar 9.

Roche R&D Center(China) Ltd, 720 Cai Lun Road, Building 5, Pudong, Shanghai 201203, China.

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May 2009

Radially expanding transglial calcium waves in the intact cerebellum.

Proc Natl Acad Sci U S A 2009 Mar 11;106(9):3496-501. Epub 2009 Feb 11.

Department of Molecular Biology and Princeton Neuroscience Institute, Princeton University, Lewis Thomas Laboratory, Washington Road, Princeton, NJ 08544, USA.

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March 2009

Allosteric FBPase inhibitors gain 10(5) times in potency when simultaneously binding two neighboring AMP sites.

Bioorg Med Chem Lett 2008 Aug 5;18(16):4708-12. Epub 2008 Jul 5.

F. Hoffmann-La Roche Ltd, Discovery Research Basel, CH-4070 Basel, Switzerland.

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August 2008

Rhenium and technetium complexes with tridentate N-[(N'',N''-dialkylamino)(thiocarbonyl)]-N'-substituted benzamidine ligands.

Inorg Chem 2008 Jun 13;47(12):5136-44. Epub 2008 May 13.

Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.

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June 2008

ANNINE-6plus, a voltage-sensitive dye with good solubility, strong membrane binding and high sensitivity.

Eur Biophys J 2008 Apr 9;37(4):509-14. Epub 2007 Aug 9.

Department of Membrane and Neurophysics, Max Planck Institute for Biochemistry, Munich, Germany.

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April 2008

Small molecule conformational preferences derived from crystal structure data. A medicinal chemistry focused analysis.

J Chem Inf Model 2008 Jan 10;48(1):1-24. Epub 2008 Jan 10.

Discovery Chemistry, Roche Palo Alto LLC, Palo Alto, California, USA.

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January 2008

Molecular layer interneurons relay cerebellar cortical activity to Bergmann glial cells.

J Neurosci 2007 Oct;27(42):11167-9

Department of Molecular Biology, Program in Neuroscience, Princeton University, Princeton, New Jersey 08544, USA.

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October 2007

Molecular recognition of ligands in dipeptidyl peptidase IV.

Curr Top Med Chem 2007 ;7(6):609-19

F. Hoffmann-La Roche Ltd, Discovery Research Basel, CH-4070 Basel, Switzerland.

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May 2007

Synthesis and evaluation of anilinohexafluoroisopropanols as activators/modulators of LXRalpha and beta.

Bioorg Med Chem Lett 2006 Oct 31;16(19):5231-7. Epub 2006 Jul 31.

F. Hoffmann-La Roche Ltd., Pharmaceuticals Division, Preclinical Research, CH-4070 Basel, Switzerland.

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October 2006

Structure-based design of indole propionic acids as novel PPARalpha/gamma co-agonists.

Bioorg Med Chem Lett 2006 Aug 5;16(15):4016-20. Epub 2006 Jun 5.

F. Hoffmann-La Roche Ltd, Discovery Research Basel, CH-4070 Basel, Switzerland.

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August 2006

Validation and use of the MM-PBSA approach for drug discovery.

J Med Chem 2005 Jun;48(12):4040-8

Molecular Design, Pharmaceutical Division, F. Hoffmann-La Roche AG, Basel, Switzerland.

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June 2005

Prediction of pKa shifts in proteins using a combination of molecular mechanical and continuum solvent calculations.

J Comput Chem 2004 Nov;25(15):1865-72

Molecular Design, Pharmaceutical Division, F. Hoffmann-La Roche AG, CH-4070 Basel, Switzerland.

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November 2004

High sensitivity of Stark-shift voltage-sensing dyes by one- or two-photon excitation near the red spectral edge.

Biophys J 2004 Jul;87(1):631-9

Department for Biomedical Optics, Max Planck Institute for Medical Research, Heidelberg, Germany.

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July 2004

Fluorine in medicinal chemistry.

Chembiochem 2004 May;5(5):637-43

Discovery Research, Pharmaceuticals Division, Roche, CH 4070 Basel, Switzerland.

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May 2004

Differentiation of cerebral tumors using multi-section echo planar MR perfusion imaging.

Eur J Radiol 2003 Dec;48(3):244-51

Klinik für Diagnostische Radiologie, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.

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December 2003