Publications by authors named "Bernd Kuhn"

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Ligand channel in pharmacologically stabilized rhodopsin.
Proc Natl Acad Sci U S A 2018 Apr 19;115(14):3640-3645. Epub 2018 Mar 19.
Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland;

Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.
J Med Chem 2018 Apr 13;61(8):3350-3369. Epub 2018 Apr 13.
Roche Pharmaceutical Research and Early Development (pRED), Roche Innovation Center Basel , F. Hoffmann-La Roche Ltd. , Grenzacherstrasse 124 , 4070 Basel , Switzerland.

2 H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design.
J Med Chem 2018 Apr 6;61(8):3370-3388. Epub 2018 Apr 6.
Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel , F. Hoffmann-La Roche Ltd. , Grenzacherstrasse 124 , 4070 Basel , Switzerland.


Building Bridges through Science.
Neuron 2017 Nov;96(4):730-735
Achucarro Basque Center for Neuroscience, 48940 Leioa, Spain. Electronic address:

Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors.
J Med Chem 2017 Mar 13;60(6):2485-2497. Epub 2017 Mar 13.
Roche Pharmaceutical Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. , Grenzacherstrasse 124, 4070 Basel, Switzerland.

Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors.
ACS Med Chem Lett 2016 Aug 25;7(8):802-6. Epub 2016 Jun 25.
Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Shanghai , 720 Cailun Road, Shanghai 201203, China.

Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2).
Org Biomol Chem 2016 Jul 1;14(25):5922-7. Epub 2016 Jun 1.
Medicinal Chemistry, Roche Pharmaceutical Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, CH-4070 Basel, Switzerland.

Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery.
J Med Chem 2015 Nov 17;58(22):9041-60. Epub 2015 Nov 17.
Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche AG , Grenzacherstrasse 124, CH-4070 Basel, Switzerland.



Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases.
Chimia (Aarau) 2015 Aug;69(7):407-413
Roche Pharmaceutical Research and Early Development (pRED), Roche Innovation Center Basel, Medicinal Chemistry, 124 Grenzacherstrasse, B 92 / 4.92, CH-4070 Basel, Switzerland.

Intravoxel incoherent motion diffusion-weighted MR imaging of the liver: effect of triggering methods on regional variability and measurement repeatability of quantitative parameters.
Radiology 2015 Feb 17;274(2):405-15. Epub 2014 Sep 17.
From the Department of Radiology and Research Institute of Radiology (Y.L., S.S.L., N.K., E.K., Y.J.K., S.H.P., S.Y.K., M.G.L.) and Department of Clinical Epidemiology and Biostatistics (S.C.Y.), University of Ulsan College of Medicine, Asan Medical Center, 86 Asanbyeongwon-Gil, Songpa-Gu, Seoul 138-736, South Korea; Siemens AG, Healthcare, Oncology Applications Development, Erlangen, Germany (B.K.); and Siemens Healthcare Korea, Seoul, South Korea (I.S.K.).




Systematic investigation of halogen bonding in protein-ligand interactions.
Angew Chem Int Ed Engl 2011 Jan;50(1):314-8
Laboratorium für Organische Chemie, ETH Zürich, Wolfgang-Pauli-Strasse 10, HCI, 8093 Zürich, Switzerland.






Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists.
Bioorg Med Chem Lett 2007 Mar 15;17(5):1307-11. Epub 2006 Dec 15.
Pharmaceutical Division, Discovery Research, F. Hoffmann-La Roche Ltd, CH-4070 Basel, Switzerland.


Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases.
Chimia (Aarau) 2015 ;69(7-8):407-13
Roche Pharmaceutical Research and Early Development (pRED), Roche Innovation Center Basel, Medicinal Chemistry, 124 Grenzacherstrasse, B 92 / 4.92, CH-4070 Basel, Switzerland.

A Real-World Perspective on Molecular Design.
J Med Chem 2016 05 24;59(9):4087-102. Epub 2016 Feb 24.
Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. , Grenzacherstrasse 124, 4070 Basel, Switzerland.



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