Publications by authors named "Bernd Kaina"

98Publications

Benzo[a]pyrene represses DNA repair through altered E2F1/E2F4 function marking an early event in DNA damage-induced cellular senescence.

Nucleic Acids Res 2020 Nov 9. Epub 2020 Nov 9.

Institute of Toxicology, University Medical Center, Johannes Gutenberg University of Mainz, Obere Zahlbacher Str. 67, D-55131 Mainz, Germany.

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http://dx.doi.org/10.1093/nar/gkaa965DOI Listing
November 2020

Pilot Study on Malnutrition and DNA Damage in Patients with Newly Diagnosed Gastrointestinal Tumors: Is DNA Damage Reversible by Early Individualized Nutritional Support?

J Gastrointestin Liver Dis 2020 Oct 27. Epub 2020 Oct 27.

1 st Clinic and Polyclinic of Internal Medicine, University Medical Center Mainz; Medical Clinic 2, Dept. of Diabetology and Endocrinology, Clinic of Worms, Germany.

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http://dx.doi.org/10.15403/jgld-2589DOI Listing
October 2020

Cytotoxic and Senolytic Effects of Methadone in Combination with Temozolomide in Glioblastoma Cells.

Int J Mol Sci 2020 Sep 23;21(19). Epub 2020 Sep 23.

Federal Institute for Drugs and Medical Devices, Kurt-Georg-Kiesinger-Allee 3, 53175 Bonn, Germany.

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http://dx.doi.org/10.3390/ijms21197006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582495PMC
September 2020

Genotoxic and cytotoxic potential of methacrylate-based orthodontic adhesives.

Clin Oral Investig 2020 Sep 24. Epub 2020 Sep 24.

Department of Orthodontics and Orofacial Orthopedics, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.

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http://dx.doi.org/10.1007/s00784-020-03569-xDOI Listing
September 2020

A genome-wide screening for DNA repair genes: much more players than hitherto known.

Authors:
Bernd Kaina

Signal Transduct Target Ther 2020 Sep 15;5(1):204. Epub 2020 Sep 15.

Institute of Toxicology, University Medical Center, Obere Zahlbacher Str. 67, Mainz, Germany.

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http://dx.doi.org/10.1038/s41392-020-00314-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493888PMC
September 2020

Curcumin Administered as Micellar Solution Suppresses Intestinal Inflammation and Colorectal Carcinogenesis.

Nutr Cancer 2020 May 29:1-8. Epub 2020 May 29.

Institute of Toxicology, University Medical Center, Mainz, Germany.

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http://dx.doi.org/10.1080/01635581.2020.1771384DOI Listing
May 2020

Temozolomide in Glioblastoma Therapy: Role of Apoptosis, Senescence and Autophagy. Comment on Strobel et al., Temozolomide and Other Alkylating Agents in Glioblastoma Therapy. 2019, , 69.

Authors:
Bernd Kaina

Biomedicines 2019 Nov 11;7(4). Epub 2019 Nov 11.

Institute of Toxicology, University Medical Center Mainz, Obere Zahlbacher Strasse 65, D-55130 Mainz, Germany.

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http://dx.doi.org/10.3390/biomedicines7040090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966492PMC
November 2019

Epigenetic regulation of DNA repair genes and implications for tumor therapy.

Mutat Res 2019 Apr - Jun;780:15-28. Epub 2017 Oct 7.

Department of Toxicology, University of Mainz, Obere Zahlbacher Str. 67, D-55131 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.mrrev.2017.10.001DOI Listing
March 2020

Corrigendum to "DNA repair in personalized brain cancer therapy with temozolomide and nitrosoureas" [DNA Repair 78 (2019) 128-141].

DNA Repair (Amst) 2019 Aug 17;80:93. Epub 2019 Jun 17.

Department of Toxicology, University Medical Center, Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1016/j.dnarep.2019.06.003DOI Listing
August 2019

DNA repair in personalized brain cancer therapy with temozolomide and nitrosoureas.

DNA Repair (Amst) 2019 06 15;78:128-141. Epub 2019 Apr 15.

Institute of Toxicology, University Medical Center Mainz, Obere Zahlbacher Str. 67, D-55131 Mainz, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S15687864193008
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http://dx.doi.org/10.1016/j.dnarep.2019.04.007DOI Listing
June 2019

Are There Thresholds in Glioblastoma Cell Death Responses Triggered by Temozolomide?

Authors:
Yang He Bernd Kaina

Int J Mol Sci 2019 Mar 28;20(7). Epub 2019 Mar 28.

Institute of Toxicology, University Medical Center, Obere Zahlbacher Str. 67, D-55131 Mainz, Germany.

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http://dx.doi.org/10.3390/ijms20071562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480213PMC
March 2019

The SIAH1-HIPK2-p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death.

Mol Cancer Res 2019 05 22;17(5):1129-1141. Epub 2019 Feb 22.

Institute of Toxicology, University Medical Center, Mainz, Germany.

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http://dx.doi.org/10.1158/1541-7786.MCR-18-1306DOI Listing
May 2019

Werner syndrome (WRN) DNA helicase and base excision repair (BER) factors maintain endothelial homeostasis.

DNA Repair (Amst) 2019 01 28;73:17-27. Epub 2018 Oct 28.

Institute of Toxicology, Medical Faculty, Heinrich Heine University Düsseldorf, Moorenstrasse 5, D-40225, Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2018.10.005DOI Listing
January 2019

Inherent and toxicant-provoked reduction in DNA repair capacity: A key mechanism for personalized risk assessment, cancer prevention and intervention, and response to therapy.

Int J Hyg Environ Health 2018 08 21;221(7):993-1006. Epub 2018 Jul 21.

Shantou University Medical College, Shantou, China; University of Medicine and Pharmacy, Tirgu Mures, Romania; University of Texas Medical Branch, Galveston, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijheh.2018.07.003DOI Listing
August 2018

The impact of the IGF-1 system of cancer cells on radiation response - An study.

Clin Transl Radiat Oncol 2017 Dec 5;7:1-8. Epub 2017 Oct 5.

Department of Endocrinology and Metabolic Diseases, University Medical Center, Mainz, Germany.

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http://dx.doi.org/10.1016/j.ctro.2017.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862664PMC
December 2017

XRCC3 contributes to temozolomide resistance of glioblastoma cells by promoting DNA double-strand break repair.

Cancer Lett 2018 06 22;424:119-126. Epub 2018 Mar 22.

Department of Toxicology, University Medical Center Mainz, Obere Zahlbacher Str. 67, D-55131, Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.03.025DOI Listing
June 2018

Repair gene O -methylguanine-DNA methyltransferase is controlled by SP1 and up-regulated by glucocorticoids, but not by temozolomide and radiation.

J Neurochem 2018 01 1;144(2):139-151. Epub 2018 Jan 1.

Department of Toxicology, University Medical Center Mainz, Mainz, Germany.

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http://dx.doi.org/10.1111/jnc.14262DOI Listing
January 2018

Uptake of glucose-conjugated MGMT inhibitors in cancer cells: role of flippases and type IV P-type ATPases.

Sci Rep 2017 10 24;7(1):13925. Epub 2017 Oct 24.

Department of Toxicology, University Medical Center, Obere Zahlbacher Strasse 67, D-55131, Mainz, Germany.

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http://dx.doi.org/10.1038/s41598-017-14129-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655675PMC
October 2017

Genotoxicity testing: Comparison of the γH2AX focus assay with the alkaline and neutral comet assays.

Mutat Res 2017 10 22;822:10-18. Epub 2017 Jul 22.

Institute of Toxicology, University Medical Center, Mainz, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13835718173009
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http://dx.doi.org/10.1016/j.mrgentox.2017.07.004DOI Listing
October 2017

AKT2 suppresses pro-survival autophagy triggered by DNA double-strand breaks in colorectal cancer cells.

Cell Death Dis 2017 08 24;8(8):e3019. Epub 2017 Aug 24.

Department of Toxicology, University Medical Center Mainz, Mainz, Germany.

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http://dx.doi.org/10.1038/cddis.2017.418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596597PMC
August 2017

DNA damage in lymphocytes of patients suffering from complex traumatization.

DNA Repair (Amst) 2017 04 9;52:103-109. Epub 2017 Feb 9.

Institute of Toxicology, University Medical Center, Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2017.02.006DOI Listing
April 2017

Chloroethylating nitrosoureas in cancer therapy: DNA damage, repair and cell death signaling.

Biochim Biophys Acta Rev Cancer 2017 Aug 29;1868(1):29-39. Epub 2017 Jan 29.

Institute of Toxicology, University Medical Center, Obere Zahlbacher Str. 67, D-55131 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2017.01.004DOI Listing
August 2017

Death of Monocytes through Oxidative Burst of Macrophages and Neutrophils: Killing in Trans.

PLoS One 2017 18;12(1):e0170347. Epub 2017 Jan 18.

Department of Toxicology, University Medical Center, Mainz, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0170347PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242493PMC
August 2017

Targeting Homologous Recombination by Pharmacological Inhibitors Enhances the Killing Response of Glioblastoma Cells Treated with Alkylating Drugs.

Mol Cancer Ther 2016 11 29;15(11):2665-2678. Epub 2016 Jul 29.

Institute of Toxicology, University Medical Center Mainz, Mainz, Germany.

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http://dx.doi.org/10.1158/1535-7163.MCT-16-0176DOI Listing
November 2016

Quantification of Radiation Biomarkers in Leukocytes of Breast Cancer Patients Treated with Different Modalities of 3D-CRT or IMRT.

Radiat Res 2016 Nov 27;186(5):508-519. Epub 2016 Oct 27.

a   Radiation Oncology and Radiation Therapy and.

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http://dx.doi.org/10.1667/RR14475.1DOI Listing
November 2016

Past, present and future of immunology in Mainz.

Cell Immunol 2016 10;308:1-6

Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg University, Mainz, Germany; Institute for Immunology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1016/j.cellimm.2016.09.001DOI Listing
October 2016

Adaptive upregulation of DNA repair genes following benzo(a)pyrene diol epoxide protects against cell death at the expense of mutations.

Nucleic Acids Res 2016 12 30;44(22):10727-10743. Epub 2016 Sep 30.

Department of Toxicology, University Medical Center Mainz, Obere Zahlbacher Strasse 67, D-55131 Mainz, Germany

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http://dx.doi.org/10.1093/nar/gkw873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159553PMC
December 2016

Impact of DNA repair on the dose-response of colorectal cancer formation induced by dietary carcinogens.

Food Chem Toxicol 2017 Aug 6;106(Pt B):583-594. Epub 2016 Oct 6.

Department of Toxicology, University Medical Center Mainz, Obere Zahlbacher Strasse 67, D-55131 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2016.09.029DOI Listing
August 2017

Artesunate enhances the therapeutic response of glioma cells to temozolomide by inhibition of homologous recombination and senescence.

Oncotarget 2016 Oct;7(41):67235-67250

Department of Toxicology, Medical Center of University of Mainz, D-55131 Mainz, Germany.

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http://dx.doi.org/10.18632/oncotarget.11972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341871PMC
October 2016

Nitroglycerin induces DNA damage and vascular cell death in the setting of nitrate tolerance.

Basic Res Cardiol 2016 07 29;111(4):52. Epub 2016 Jun 29.

Center of Cardiology-Cardiology 1, Molecular Cardiology, University Medical Center of the Johannes Gutenberg University, Langenbeckstr. 1, 55101, Mainz, Germany.

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http://dx.doi.org/10.1007/s00395-016-0571-4DOI Listing
July 2016

MGMT promoter methylation determined by HRM in comparison to MSP and pyrosequencing for predicting high-grade glioma response.

Clin Epigenetics 2016 5;8:49. Epub 2016 May 5.

Department of Toxicology, University Medical Center of the Johannes Gutenberg University Mainz, Obere Zahlbacher Strasse 67, 55131 Mainz, Germany.

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http://dx.doi.org/10.1186/s13148-016-0204-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858829PMC
December 2016

The γH2AX DNA damage assay from a drop of blood.

Sci Rep 2016 Mar 4;6:22682. Epub 2016 Mar 4.

Institute of Toxicology, University Medical Center, Obere Zahlbacher Str. 67, D-55131 Mainz, Germany.

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http://dx.doi.org/10.1038/srep22682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778029PMC
March 2016

The Brassica-derived phytochemical indolo[3,2-b]carbazole protects against oxidative DNA damage by aryl hydrocarbon receptor activation.

Arch Toxicol 2017 Feb 8;91(2):967-982. Epub 2016 Feb 8.

Institute of Toxicology, University Medical Center of the Johannes Gutenberg-University Mainz, Obere Zahlbacherstr. 67, 55131, Mainz, Germany.

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http://dx.doi.org/10.1007/s00204-016-1672-4DOI Listing
February 2017

DNA damage and the balance between survival and death in cancer biology.

Nat Rev Cancer 2016 Jan 18;16(1):20-33. Epub 2015 Dec 18.

Institute of Toxicology, University Medical Center, Obere Zahlbacher Strasse 67, D-55131 Mainz, Germany.

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http://dx.doi.org/10.1038/nrc.2015.2DOI Listing
January 2016

Multidrug Efflux Pumps Attenuate the Effect of MGMT Inhibitors.

Mol Pharm 2015 Nov 1;12(11):3924-34. Epub 2015 Oct 1.

Department of Toxicology, University Medical Center , Obere Zahlbacher Strasse 67, D-55131 Mainz, Germany.

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http://dx.doi.org/10.1021/acs.molpharmaceut.5b00341DOI Listing
November 2015

Theoretical considerations for thresholds in chemical carcinogenesis.

Mutat Res Rev Mutat Res 2015 Jul-Sep;765:56-67. Epub 2015 May 27.

Institute of Toxicology, University Medical Centre, Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.mrrev.2015.05.001DOI Listing
November 2015

DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis.

Carcinogenesis 2015 Oct 4;36(10):1235-44. Epub 2015 Aug 4.

Institute of Molecular Medicine, University Medical Center Mainz, Obere Zahlbacher Str. 67, D-55131 Mainz, Germany.

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http://dx.doi.org/10.1093/carcin/bgv114DOI Listing
October 2015

Lipoic acid inhibits the DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction.

Carcinogenesis 2015 Aug 21;36(8):817-31. Epub 2015 May 21.

Department of Toxicology, University Medical Center Mainz, Obere Zahlbacher Strasse 67, D-55131 Mainz, Germany

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http://dx.doi.org/10.1093/carcin/bgv070DOI Listing
August 2015

Biodosimetry Based on γ-H2AX Quantification and Cytogenetics after Partial- and Total-Body Irradiation during Fractionated Radiotherapy.

Radiat Res 2015 Apr 6;183(4):432-46. Epub 2015 Apr 6.

a  Department of Radiation Oncology and Radiotherapy, University Medical Center Johannes Gutenberg University Mainz, 55131 Mainz, Germany.

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http://dx.doi.org/10.1667/RR13911.1DOI Listing
April 2015

The bacterial alkyltransferase-like (eATL) protein protects mammalian cells against methylating agent-induced toxicity.

DNA Repair (Amst) 2015 Apr 31;28:14-20. Epub 2015 Jan 31.

Department of Toxicology, University Medical Center, Obere Zahlbacher Strasse 67, D-55131 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2015.01.009DOI Listing
April 2015

Rac1 promotes diethylnitrosamine (DEN)-induced formation of liver tumors.

Carcinogenesis 2015 Mar 2;36(3):378-89. Epub 2015 Jan 2.

Institute of Toxicology, Heinrich Heine University Düsseldorf, Moorenstrasse 5, D-40225 Düsseldorf, Germany,

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http://dx.doi.org/10.1093/carcin/bgu323DOI Listing
March 2015

Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil.

Arch Toxicol 2015 Oct 20;89(10):1829-46. Epub 2014 Dec 20.

Department of Toxicology, University Medical Center, Obere Zahlbacher Str. 67, 55131, Mainz, Germany.

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http://dx.doi.org/10.1007/s00204-014-1434-0DOI Listing
October 2015

Translesion polymerase η is upregulated by cancer therapeutics and confers anticancer drug resistance.

Cancer Res 2014 Oct 14;74(19):5585-96. Epub 2014 Aug 14.

Department of Toxicology, University Medical Center Mainz, Mainz, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0953DOI Listing
October 2014

DNA breaks and chromosomal aberrations arise when replication meets base excision repair.

J Cell Biol 2014 Jul 30;206(1):29-43. Epub 2014 Jun 30.

Radiation Biology and DNA Repair, Darmstadt University of Technology, 64287 Darmstadt, Germany.

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http://dx.doi.org/10.1083/jcb.201312078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085701PMC
July 2014

The eucalyptus oil ingredient 1,8-cineol induces oxidative DNA damage.

Arch Toxicol 2015 May 10;89(5):797-805. Epub 2014 Jun 10.

Department of Toxicology, University Medical Center Mainz, Obere Zahlbacher Str. 67, 55131, Mainz, Germany.

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http://dx.doi.org/10.1007/s00204-014-1281-zDOI Listing
May 2015

Radiation sensitivity of human and murine peripheral blood lymphocytes, stem and progenitor cells.

Biochim Biophys Acta 2014 Aug 4;1846(1):121-9. Epub 2014 May 4.

Department of Toxicology, University Medical Center, Obere Zahlbacher Straße 67, D-55131 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2014.04.009DOI Listing
August 2014

The γH2AX assay for genotoxic and nongenotoxic agents: comparison of H2AX phosphorylation with cell death response.

Toxicol Sci 2014 Jul 17;140(1):103-17. Epub 2014 Apr 17.

Institute of Toxicology, University Medical Center, Obere Zahlbacher Str. 67, D-55131 Mainz, Germany

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http://dx.doi.org/10.1093/toxsci/kfu066DOI Listing
July 2014

Cytolethal distending toxin (CDT) is a radiomimetic agent and induces persistent levels of DNA double-strand breaks in human fibroblasts.

DNA Repair (Amst) 2014 Jun 25;18:31-43. Epub 2014 Mar 25.

Department of Toxicology, University Medical Center Mainz, Germany; Institute of Toxicology, Heinrich Heine University Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2014.03.002DOI Listing
June 2014

Does increase in DNA repair allow "tolerance-to-insult" in chemical carcinogenesis? Skin tumor experiments with MGMT-overexpressing mice.

Environ Mol Mutagen 2014 Mar 1;55(2):145-50. Epub 2013 Dec 1.

Institute of Plant Genetics and Crop Plant Research, Gatersleben, Germany.

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http://dx.doi.org/10.1002/em.21834DOI Listing
March 2014

Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model.

EMBO Mol Med 2013 Dec 4;5(12):1804-20. Epub 2013 Oct 4.

Medical Center of the Johannes Gutenberg-University Mainz, Department of Internal Medicine III, Division of Translational and Experimental Oncology, Mainz, Germany; German Cancer Research Center, Department of Stem Cells and Cancer, Heidelberg, Germany; Medical Center of the Johannes Gutenberg-University Mainz, Institute for Toxicology, Mainz, Germany.

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http://dx.doi.org/10.1002/emmm.201302661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914523PMC
December 2013

Contribution of ATM and ATR to the resistance of glioblastoma and malignant melanoma cells to the methylating anticancer drug temozolomide.

Mol Cancer Ther 2013 Nov 19;12(11):2529-40. Epub 2013 Aug 19.

Corresponding Author: Bernd Kaina, Institute of Toxicology, Medical Center of the University Mainz, Obere Zahlbacher Str. 67, D-55131 Mainz, Germany.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0136DOI Listing
November 2013

O6-methylguanine-DNA methyltransferase in the defense against N-nitroso compounds and colorectal cancer.

Carcinogenesis 2013 Nov 8;34(11):2435-42. Epub 2013 Aug 8.

Department of Toxicology, University Medical Center Mainz, Obere Zahlbacher Strasse 67, D-55131 Mainz, Germany.

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http://dx.doi.org/10.1093/carcin/bgt275DOI Listing
November 2013

Cytotoxicity and induction of DNA double-strand breaks by components leached from dental composites in primary human gingival fibroblasts.

Dent Mater 2013 Sep 31;29(9):971-9. Epub 2013 Jul 31.

Department of Operative/Restorative Dentistry, Periodontology and Pedodontics, Ludwig-Maximilians-University of Munich, Goethestr. 70, 80336 Munich, Germany.

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http://dx.doi.org/10.1016/j.dental.2013.07.007DOI Listing
September 2013

Transcriptional regulation of human DNA repair genes following genotoxic stress: trigger mechanisms, inducible responses and genotoxic adaptation.

Nucleic Acids Res 2013 Oct 27;41(18):8403-20. Epub 2013 Jul 27.

Department of Toxicology, University Medical Center, Obere Zahlbacher Str. 67, D-55131 Mainz, Germany.

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http://dx.doi.org/10.1093/nar/gkt635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794595PMC
October 2013

Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs.

Biochim Biophys Acta 2013 Aug 8;1833(8):1832-43. Epub 2013 Apr 8.

Department of Toxicology, University Medical Center, Mainz, Germany.

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http://dx.doi.org/10.1016/j.bbamcr.2013.03.029DOI Listing
August 2013

Influence of DNA repair on nonlinear dose-responses for mutation.

Toxicol Sci 2013 Mar 3;132(1):87-95. Epub 2013 Jan 3.

Institute of Life Science, College of Medicine, Swansea University, SA2 8PP, UK.

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http://dx.doi.org/10.1093/toxsci/kfs341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576011PMC
March 2013

AhR-mediated changes in global gene expression in rat liver progenitor cells.

Arch Toxicol 2013 Apr 30;87(4):681-98. Epub 2012 Nov 30.

Institute of Toxicology, University Medical Center of the Johannes Gutenberg-University Mainz, Germany.

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http://dx.doi.org/10.1007/s00204-012-0979-zDOI Listing
April 2013

Nutrition in adult and childhood cancer: role of carcinogens and anti-carcinogens.

Anticancer Res 2012 Oct;32(10):4171-92

St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678, USA.

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October 2012

Rac1 protein signaling is required for DNA damage response stimulated by topoisomerase II poisons.

J Biol Chem 2012 Nov 25;287(46):38590-9. Epub 2012 Sep 25.

Institute of Toxicology, Heinrich-Heine-University Düsseldorf, Moorenstrasse 5, D-40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1074/jbc.M112.377903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493904PMC
November 2012

Topoisomerase degradation, DSB repair, p53 and IAPs in cancer cell resistance to camptothecin-like topoisomerase I inhibitors.

Biochim Biophys Acta 2013 Jan 21;1835(1):11-27. Epub 2012 Sep 21.

Department of Toxicology, University Medical Center Mainz, Germany.

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http://dx.doi.org/10.1016/j.bbcan.2012.09.002DOI Listing
January 2013

Chloroethylnitrosourea-induced cell death and genotoxicity: cell cycle dependence and the role of DNA double-strand breaks, HR and NHEJ.

Cell Cycle 2012 Jul 15;11(14):2606-19. Epub 2012 Jul 15.

Institute of Toxicology, University Medical Center, Mainz, Germany.

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July 2012

The lipid lowering drug lovastatin protects against doxorubicin-induced hepatotoxicity.

Toxicol Appl Pharmacol 2012 May;261(1):66-73

Institute of Toxicology, University Medical Center of the Johannes Gutenberg University Mainz, Obere Zahlbacher Str. 67, D-55131 Mainz, Germany.

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http://dx.doi.org/10.1016/j.taap.2012.03.012DOI Listing
May 2012

The chloroethylating anticancer drug ACNU induces FRA1 that is involved in drug resistance of glioma cells.

Biochim Biophys Acta 2012 Jul 15;1823(7):1199-207. Epub 2012 May 15.

Department of Toxicology, University Medical Center Mainz, Mainz, Germany.

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http://dx.doi.org/10.1016/j.bbamcr.2012.05.008DOI Listing
July 2012

Temozolomide dosing regimens for glioma patients.

Curr Neurol Neurosci Rep 2012 Jun;12(3):286-93

Department of Neurology, Medical School, University of Marburg, Baldinger Strasse, 35043 Marburg, Germany.

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http://link.springer.com/10.1007/s11910-012-0262-y
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June 2012

DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis.

Cancer Lett 2013 May 17;332(2):237-48. Epub 2012 Jan 17.

Department of Toxicology, University of Mainz, Obere Zahlbacher Str. 67, D-55131 Mainz, Germany.

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http://dx.doi.org/10.1016/j.canlet.2012.01.007DOI Listing
May 2013

Human monocytes are severely impaired in base and DNA double-strand break repair that renders them vulnerable to oxidative stress.

Proc Natl Acad Sci U S A 2011 Dec 12;108(52):21105-10. Epub 2011 Dec 12.

Institute of Toxicology, University Medical Center Mainz, D-55131 Mainz, Germany.

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http://dx.doi.org/10.1073/pnas.1111919109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248544PMC
December 2011

Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs.

PLoS One 2011 2;6(11):e27183. Epub 2011 Nov 2.

Institute for Toxicology, Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206939PMC
March 2012

Artesunate induces oxidative DNA damage, sustained DNA double-strand breaks, and the ATM/ATR damage response in cancer cells.

Mol Cancer Ther 2011 Dec 13;10(12):2224-33. Epub 2011 Oct 13.

Institute of Toxicology, University Medical Center, Johannes Gutenberg University, Mainz, Germany.

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December 2011

Toxicities by herbal medicines with emphasis to traditional Chinese medicine.

Curr Drug Metab 2011 Dec;12(10):989-96

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany.

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http://dx.doi.org/10.2174/138920011798062328DOI Listing
December 2011

Intrinsic anticancer drug resistance of malignant melanoma cells is abrogated by IFN-β and valproic acid.

Cancer Res 2011 Jun 14;71(12):4150-60. Epub 2011 Apr 14.

Institute of Toxicology, Medical Center of the University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3498DOI Listing
June 2011

Extent and patterns of MGMT promoter methylation in glioblastoma- and respective glioblastoma-derived spheres.

Clin Cancer Res 2011 Jan 19;17(2):255-66. Epub 2010 Nov 19.

Laboratory of Brain Tumor Biology, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.

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January 2011

Delayed c-Fos activation in human cells triggers XPF induction and an adaptive response to UVC-induced DNA damage and cytotoxicity.

Cell Mol Life Sci 2011 May 26;68(10):1785-98. Epub 2010 Oct 26.

Department of Toxicology, University Medical Center Mainz, Obere Zahlbacher Str. 67, 55131, Mainz, Germany.

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http://dx.doi.org/10.1007/s00018-010-0546-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078315PMC
May 2011

Cisplatin sensitivity of testis tumour cells is due to deficiency in interstrand-crosslink repair and low ERCC1-XPF expression.

Mol Cancer 2010 Sep 16;9:248. Epub 2010 Sep 16.

Institute of Toxicology, Clinical Centre of University of Mainz, Obere Zahlbacher Strasse 67, 55131 Mainz, Germany.

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http://dx.doi.org/10.1186/1476-4598-9-248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098011PMC
September 2010

Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis.

Carcinogenesis 2010 Dec 23;31(12):2111-7. Epub 2010 Aug 23.

Department of Molecular Medicine, University of Erlangen-Nuremberg, D-91052 Erlangen, German.

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http://dx.doi.org/10.1093/carcin/bgq174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994278PMC
December 2010