Publications by authors named "Bernard Thorens"

100Publications

EphrinB1 modulates glutamatergic inputs into POMC-expressing progenitors and controls glucose homeostasis.

PLoS Biol 2020 Nov 30;18(11):e3000680. Epub 2020 Nov 30.

Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1371/journal.pbio.3000680DOI Listing
November 2020

A genetic screen identifies Crat as a regulator of pancreatic beta-cell insulin secretion.

Mol Metab 2020 07 13;37:100993. Epub 2020 Apr 13.

Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2020.100993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225740PMC
July 2020

Klf6 protects β-cells against insulin resistance-induced dedifferentiation.

Mol Metab 2020 05 6;35:100958. Epub 2020 Feb 6.

Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2020.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093812PMC
May 2020

Targeting the Brain to Cure Type 2 Diabetes.

Authors:
Bernard Thorens

Diabetes 2019 03;68(3):476-478

Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/dbi1
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http://dx.doi.org/10.2337/dbi18-0051DOI Listing
March 2019

SLC2A9 (GLUT9) mediates urate reabsorption in the mouse kidney.

Pflugers Arch 2018 12 13;470(12):1739-1751. Epub 2018 Aug 13.

Department of Pharmacology and Toxicology, University of Lausanne, 27 rue du Bugnon, 1011, Lausanne, Switzerland.

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http://dx.doi.org/10.1007/s00424-018-2190-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224025PMC
December 2018

Protective role of the ELOVL2/docosahexaenoic acid axis in glucolipotoxicity-induced apoptosis in rodent beta cells and human islets.

Diabetologia 2018 08 12;61(8):1780-1793. Epub 2018 May 12.

Unité Biologie Fonctionnelle et Adaptative, CNRS UMR 8251, Équipe Régulation de la glycémie par le système nerveux central, Université Paris Diderot, 4 rue Marie-Andrée-Lagroua-Weill-Hallé, 75205, Paris CEDEX 13, France.

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http://dx.doi.org/10.1007/s00125-018-4629-8DOI Listing
August 2018

Glucose transporter 2 mediates the hypoglycemia-induced increase in cerebral blood flow.

J Cereb Blood Flow Metab 2019 09 21;39(9):1725-1736. Epub 2018 Mar 21.

3 Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1177/0271678X18766743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727137PMC
September 2019

α-cell glucokinase suppresses glucose-regulated glucagon secretion.

Nat Commun 2018 02 7;9(1):546. Epub 2018 Feb 7.

Center for Integrative Genomics, University of Lausanne, 1015, Lausanne, Switzerland.

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http://dx.doi.org/10.1038/s41467-018-03034-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803227PMC
February 2018

GLUT2-Expressing Neurons as Glucose Sensors in the Brain: Electrophysiological Analysis.

Methods Mol Biol 2018 ;1713:255-267

Department of Medicine, University of Fribourg, Fribourg, 1700, Switzerland.

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http://dx.doi.org/10.1007/978-1-4939-7507-5_19DOI Listing
July 2018

Alain Ktorza, PhD.

Diabetes Obes Metab 2017 09;19 Suppl 1

Department of Medicine, Endocrinology & Metabolism Service, Hadassah Medical Centre, Hebrew University of Jerusalem, Jerusalem, Israel.

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http://dx.doi.org/10.1111/dom.13036DOI Listing
September 2017

Sex-Specific Control of Fat Mass and Counterregulation by Hypothalamic Glucokinase.

Diabetes 2016 10 15;65(10):2920-31. Epub 2016 Jul 15.

Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland

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http://dx.doi.org/10.2337/db15-1514DOI Listing
October 2016

Glucose-responsive neurons of the paraventricular thalamus control sucrose-seeking behavior.

Nat Neurosci 2016 08 20;19(8):999-1002. Epub 2016 Jun 20.

Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

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http://www.nature.com/articles/nn.4331
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http://dx.doi.org/10.1038/nn.4331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964931PMC
August 2016

The Drosophila TNF Eiger Is an Adipokine that Acts on Insulin-Producing Cells to Mediate Nutrient Response.

Cell Metab 2016 Apr;23(4):675-84

Université Nice Sophia Antipolis, CNRS, Inserm, iBV, 06100 Nice, France. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.03.003DOI Listing
April 2016

Revisiting the physiological roles of SGLTs and GLUTs using positron emission tomography in mice.

J Physiol 2016 08 10;594(15):4425-38. Epub 2016 May 10.

The Department of Physiology and the Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1113/JP271904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967756PMC
August 2016

Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca2+ Stores.

Diabetes 2016 04 28;65(4):1009-21. Epub 2016 Jan 28.

Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology & Metabolism, Department of Medicine, Imperial College London, London, U.K.

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http://dx.doi.org/10.2337/db15-1334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806657PMC
April 2016

Autocrine Action of IGF2 Regulates Adult β-Cell Mass and Function.

Diabetes 2015 Dec 17;64(12):4148-57. Epub 2015 Sep 17.

Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db14
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http://dx.doi.org/10.2337/db14-1735DOI Listing
December 2015

Type 2 Diabetes, SGLT2 Inhibitors, and Glucose Secretion.

N Engl J Med 2015 Sep;373(10):974-6

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http://dx.doi.org/10.1056/NEJMcibr1506573DOI Listing
September 2015

Brain glucose sensing in homeostatic and hedonic regulation.

Trends Endocrinol Metab 2015 Sep 8;26(9):455-66. Epub 2015 Jul 8.

Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10432760150011
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http://dx.doi.org/10.1016/j.tem.2015.06.005DOI Listing
September 2015

Clic4, a novel protein that sensitizes β-cells to apoptosis.

Mol Metab 2015 Apr 20;4(4):253-64. Epub 2015 Jan 20.

Center for Integrative Genomics, University of Lausanne, Genopode Building, CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.molmet.2015.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354924PMC
April 2015

Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment.

Nat Med 2015 Apr 16;21(4):363-72. Epub 2015 Mar 16.

1] Institute of Metabolic Physiology, Heinrich Heine University, Düsseldorf, Germany. [2] Institute for Beta Cell Biology, German Diabetes Center, Leibniz Center for Diabetes Research, Düsseldorf, Germany. [3] German Center for Diabetes Research, Partner Düsseldorf, Düsseldorf, Germany.

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http://dx.doi.org/10.1038/nm.3822DOI Listing
April 2015

No development of hypertension in the hyperuricemic liver-Glut9 knockout mouse.

Kidney Int 2015 May 7;87(5):940-7. Epub 2015 Jan 7.

1] Mouse Metabolic Facility, University of Lausanne, Lausanne, Switzerland [2] Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

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https://linkinghub.elsevier.com/retrieve/pii/S00852538153009
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http://dx.doi.org/10.1038/ki.2014.385DOI Listing
May 2015

Ins1(Cre) knock-in mice for beta cell-specific gene recombination.

Diabetologia 2015 Mar 11;58(3):558-65. Epub 2014 Dec 11.

Center for Integrative Genomics, University of Lausanne, Genopode Building, CH-1015, Lausanne, Switzerland,

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http://dx.doi.org/10.1007/s00125-014-3468-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320308PMC
March 2015

GLUT2, glucose sensing and glucose homeostasis.

Authors:
Bernard Thorens

Diabetologia 2015 Feb 25;58(2):221-32. Epub 2014 Nov 25.

Center for Integrative Genomics, University of Lausanne, Genopode Building, 1015, Lausanne, Switzerland,

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http://dx.doi.org/10.1007/s00125-014-3451-1DOI Listing
February 2015

Role of endogenous GLP-1 and GIP in beta cell compensatory responses to insulin resistance and cellular stress.

PLoS One 2014 26;9(6):e101005. Epub 2014 Jun 26.

SAAD Centre for Pharmacy and Diabetes, University of Ulster, Coleraine, Northern Ireland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101005PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072716PMC
October 2015

Incretin receptor null mice reveal key role of GLP-1 but not GIP in pancreatic beta cell adaptation to pregnancy.

PLoS One 2014 13;9(6):e96863. Epub 2014 Jun 13.

SAAD centre for Pharmacy and Diabetes, University of Ulster, Cromore Road, Coleraine, Northern Ireland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096863PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057070PMC
October 2015

The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing.

PLoS One 2014 26;9(2):e89977. Epub 2014 Feb 26.

ZIEL Research Center for Nutrition and Food Sciences, Biochemistry Unit, Technische Universität München, Freising, Bavaria, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089977PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935955PMC
October 2014

The peroxisomal enzyme L-PBE is required to prevent the dietary toxicity of medium-chain fatty acids.

Cell Rep 2013 Oct 26;5(1):248-58. Epub 2013 Sep 26.

Center for Integrative Genomics, University of Lausanne, Lausanne 1015, Switzerland.

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http://dx.doi.org/10.1016/j.celrep.2013.08.032DOI Listing
October 2013

Urate-induced acute renal failure and chronic inflammation in liver-specific Glut9 knockout mice.

Am J Physiol Renal Physiol 2013 Sep 26;305(5):F786-95. Epub 2013 Jun 26.

Mouse Metabolic Facility of the Cardiomet Center, University Hospital, Lausanne, Switzerland.

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http://dx.doi.org/10.1152/ajprenal.00083.2013DOI Listing
September 2013

Sodium/hydrogen exchanger NHA2 is critical for insulin secretion in β-cells.

Proc Natl Acad Sci U S A 2013 Jun 29;110(24):10004-9. Epub 2013 May 29.

Institute of Biochemistry and Molecular Medicine and Swiss National Centre of Competence in Research TransCure, University of Bern, 3012 Bern, Switzerland.

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http://dx.doi.org/10.1073/pnas.1220009110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683798PMC
June 2013

The SLC2 (GLUT) family of membrane transporters.

Mol Aspects Med 2013 Apr-Jun;34(2-3):121-38

Department of Cell Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.mam.2012.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104978PMC
September 2013

Plac8 is required for white adipocyte differentiation in vitro and cell number control in vivo.

PLoS One 2012 14;7(11):e48767. Epub 2012 Nov 14.

Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048767PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498234PMC
May 2013

Sensing of glucose in the brain.

Authors:
Bernard Thorens

Handb Exp Pharmacol 2012 (209):277-94

Center for Integrative Genomics, University of Lausanne, Switzerland.

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http://dx.doi.org/10.1007/978-3-642-24716-3_12DOI Listing
April 2012

The role of sodium-coupled glucose co-transporter 3 in the satiety effect of portal glucose sensing.

Mol Metab 2012 7;2(1):47-53. Epub 2012 Dec 7.

Institut National de la Santé et de la Recherche Médicale, U 855, Lyon 69372, France ; Université de Lyon, Lyon 69008, France ; Université Lyon 1, Villeurbanne 69622, France ; AgroParisTech, ENGREF, Paris F-75732, France.

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http://dx.doi.org/10.1016/j.molmet.2012.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757661PMC
September 2013

Of fat, β cells, and diabetes.

Authors:
Bernard Thorens

Cell Metab 2011 Oct;14(4):439-40

Center for Integrative Genomics, University of Lausanne, CH-1015 Lausanne, Switzerland.

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http://linkinghub.elsevier.com/retrieve/pii/S155041311100352
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http://dx.doi.org/10.1016/j.cmet.2011.09.006DOI Listing
October 2011

PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance.

Proc Natl Acad Sci U S A 2011 Oct 26;108(42):E854-63. Epub 2011 Sep 26.

Laboratory of Metabolic Stress Biology, Division of Physiology, Department of Medicine, University of Fribourg, CH-1700 Fribourg, Switzerland.

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http://dx.doi.org/10.1073/pnas.1106698108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198370PMC
October 2011

Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice.

Diabetes 2011 Nov 16;60(11):2872-82. Epub 2011 Sep 16.

Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.2337/db11-0876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198058PMC
November 2011

Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis.

J Neurophysiol 2011 Apr 27;105(4):1574-80. Epub 2011 Jan 27.

School of Biomedical Sciences, Ulster University, Coleraine, United Kingdom.

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http://dx.doi.org/10.1152/jn.00866.2010DOI Listing
April 2011

GLP-1 protects β-cells against apoptosis by enhancing the activity of an IGF-2/IGF1-receptor autocrine loop.

Islets 2009 Nov-Dec;1(3):280-2

Department of Physiology and Center for Integrative Genomics, University of Lausanne, Génopode Building, CH-1015 Lausanne, Switzerland.

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http://www.tandfonline.com/doi/abs/10.4161/isl.1.3.9932
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http://dx.doi.org/10.4161/isl.1.3.9932DOI Listing
April 2011

Uric acid transport and disease.

J Clin Invest 2010 Jun 1;120(6):1791-9. Epub 2010 Jun 1.

Service de Rhumatologie, Department of Musculoskeletal Medicine, University of Lausanne, Lausanne, Switzerland.

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http://www.jci.org/articles/view/42344
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http://dx.doi.org/10.1172/JCI42344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877959PMC
June 2010

Neurochemical profile of the mouse hypothalamus using in vivo 1H MRS at 14.1T.

NMR Biomed 2010 Jul;23(6):578-83

Laboratory of Functional and Metabolic Imaging (LIFMET), Institute of the Physics of Biological Systems, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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http://doi.wiley.com/10.1002/nbm.1498
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http://dx.doi.org/10.1002/nbm.1498DOI Listing
July 2010

Glut2-dependent glucose-sensing controls thermoregulation by enhancing the leptin sensitivity of NPY and POMC neurons.

FASEB J 2010 Jun 22;24(6):1747-58. Epub 2010 Jan 22.

Department of Physiology and Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1096/fj.09-144923DOI Listing
June 2010

Thioredoxin-interacting protein links oxidative stress to inflammasome activation.

Nat Immunol 2010 Feb 20;11(2):136-40. Epub 2009 Dec 20.

Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.

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http://www.nature.com/articles/ni.1831
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http://dx.doi.org/10.1038/ni.1831DOI Listing
February 2010

Glucose transporters in the 21st Century.

Am J Physiol Endocrinol Metab 2010 Feb 15;298(2):E141-5. Epub 2009 Dec 15.

Department of Physiology and Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

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http://www.physiology.org/doi/10.1152/ajpendo.00712.2009
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http://dx.doi.org/10.1152/ajpendo.00712.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822486PMC
February 2010

Regulation of adaptive behaviour during fasting by hypothalamic Foxa2.

Nature 2009 Dec;462(7273):646-50

The Rockefeller University, Laboratory of Metabolic Diseases, 1230 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/nature08589DOI Listing
December 2009

Mouse GLUT9: evidences for a urate uniporter.

Am J Physiol Renal Physiol 2009 Sep 8;297(3):F612-9. Epub 2009 Jul 8.

Dept. of Pharmacology and Toxicology, Univ. of Lausanne, Rue du Bugnon 27, CH-1005 Lausanne, Switzerland.

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http://dx.doi.org/10.1152/ajprenal.00139.2009DOI Listing
September 2009

Glucagon-like peptide-1 protects beta-cells against apoptosis by increasing the activity of an IGF-2/IGF-1 receptor autocrine loop.

Diabetes 2009 Aug 28;58(8):1816-25. Epub 2009 Apr 28.

Department of Physiology and Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.2337/db09-0063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712796PMC
August 2009

Glucose-dependent insulinotropic polypeptide (GIP) and its receptor (GIPR): cellular localization, lesion-affected expression, and impaired regenerative axonal growth.

J Neurosci Res 2009 Jun;87(8):1858-70

Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University of Düsseldorf, Düsseldorf, Germany.

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http://dx.doi.org/10.1002/jnr.22001DOI Listing
June 2009

Deficiency of glucose-dependent insulinotropic polypeptide receptor prevents ovariectomy-induced obesity in mice.

Am J Physiol Endocrinol Metab 2008 Aug 27;295(2):E350-5. Epub 2008 May 27.

Department of Endocrinology, Diabetes and Nutrition, Charité-University-Medicine, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany.

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http://www.physiology.org/doi/10.1152/ajpendo.00008.2008
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http://dx.doi.org/10.1152/ajpendo.00008.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519752PMC
August 2008

Exendin-4 protects beta-cells from interleukin-1 beta-induced apoptosis by interfering with the c-Jun NH2-terminal kinase pathway.

Diabetes 2008 May 5;57(5):1205-15. Epub 2008 Feb 5.

Service of Internal Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.2337/db07-1214DOI Listing
May 2008

Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14.

Diabetes 2008 Mar 19;57(3):584-93. Epub 2007 Nov 19.

Institute of Physiology, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.2337/db07-1414DOI Listing
March 2008

Development and preclinical assessment of a bioartificial pancreas.

Authors:
Bernard Thorens

Swiss Med Wkly 2007 Mar;137 Suppl 155:68S-71S

Department of Physiology and Centre for Integrative Genomics, Génopode Building, Lausanne, Switzerland.

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March 2007

Brain glucose sensing, counterregulation, and energy homeostasis.

Physiology (Bethesda) 2007 Aug;22:241-51

Department of Physiology and Center for Integrative Genomics, Genopode Building, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1152/physiol.00010.2007DOI Listing
August 2007

GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion.

Mol Cell Endocrinol 2007 Sep 29;276(1-2):18-23. Epub 2007 Jun 29.

Institut de Médecine Moléculaire de Rangueil, I(2)MR, IFR31, CHU Rangueil, BP 84225, 31432 Toulouse cedex 4, France.

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http://linkinghub.elsevier.com/retrieve/pii/S030372070700235
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http://dx.doi.org/10.1016/j.mce.2007.06.003DOI Listing
September 2007

Maintenance of hepatic nuclear factor 6 in postnatal islets impairs terminal differentiation and function of beta-cells.

Diabetes 2006 Dec;55(12):3264-70

Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, 2220 Pierce Ave., 746 PRB, Nashville, TN 37232-6303, USA.

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http://diabetes.diabetesjournals.org/content/55/12/3264.full
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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db06-00
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http://dx.doi.org/10.2337/db06-0090DOI Listing
December 2006

GLUT8 is dispensable for embryonic development but influences hippocampal neurogenesis and heart function.

Mol Cell Biol 2006 Jun;26(11):4268-76

Institute of Physiology, University of Lausanne, Center for Integrative Genomics, Génopode Building, CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1128/MCB.00081-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1489108PMC
June 2006