Prof Bernard Salles, DVM, Pharm D , PhD - UMR 1331 TOXALIM (INRAE-Toulouse University) - Professeur émérite de l'Université de Toulouse

Prof Bernard Salles

DVM, Pharm D , PhD

UMR 1331 TOXALIM (INRAE-Toulouse University)

Professeur émérite de l'Université de Toulouse

Toulouse, Occitanie | France

Main Specialties: Biochemical Genetics, Molecular Genetic Pathology, Oncology

Additional Specialties: genotoxicology, carcinogenesis

ORCID logohttps://orcid.org/0000-0001-9062-9862


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Prof Bernard Salles, DVM, Pharm D , PhD - UMR 1331 TOXALIM (INRAE-Toulouse University) - Professeur émérite de l'Université de Toulouse

Prof Bernard Salles

DVM, Pharm D , PhD

Introduction

Bernard Salles (DVM, Pharm D, PhD) is “professor emeritus” at Toulouse University. He is involved in scientifc committees at INSERM, Anses, MSA and Ministry of Ecology. He was hired by the faculty of pharmacy as assistant professor of biochemistry and molecular biology (Toulouse University) in 1980. He was promoted in 1991 professor of Toxicology at the faculty of Pharmacy where he taught general and molecular toxicology. He created and headed the PhD college in Health Sciences and Biotechnology (1992-2003) and the master degree in oncology (2007-2014). He created and headed the research team “Radiobiology and DNA repair” (1989-2010) at the Institute of Pharmacology and Structural Biology (CNRS/University). The research program of the team was devoted to genetic instability by the analysis of the mechanisms involved in DNA damage and repair. He was invited by the Texas Medical School (1985-1986, Houston, TX; molecular genetic in bacteria, George Weinstock'group) and the Lawrence Berkeley National Laboratory (2003-2004, Berkeley, CA; DNA double strand breaks repair, David Chen's group). He headed the “Pharmacology and Toxicology” INRA unit (2009-2010), then created and headed Toxalim (INRA/University), a research center in food contaminant toxicity (about 200 persons). He is co-author of about 140 publications and 4 patents (h index 51). He was member of scientific committees at Toulouse University, Education and Research Ministry, CNRS, INSERM, INRA, ANR, HCERES and European Union. He is member of the “Académie Vétérinaire de France” since 2013.

Primary Affiliation: UMR 1331 TOXALIM (INRAE-Toulouse University) - Toulouse, Occitanie , France

Specialties:

Additional Specialties:

Research Interests:


View Prof Bernard Salles’s Resume / CV

Education

Jan 1980 - Dec 1983
Université Fédérale Toulouse Midi-Pyrénées
Dr es sciences, PhD
molecular microbiology- SOS response in E coli- director of the thesis: Claude Paoletti
Sep 1977 - Sep 1980
Université Pierre et Marie Curie
Dr 3e cycle, PhD
molecular pharmacology - cellular resistance to the DNA intercalating antitumor 9-OH ellipticine
Jul 1976 - Nov 1979
Université Paris-Est Créteil Val de Marne
Dr in veterinary medicine
mode of action of the DNA intercalating agent, 9-OH ellipticine
Jul 1977
Université Pierre et Marie Curie
Master 1 and Master 2
Master 1 in Biochemistry-Mol Biol.-Immunol and Master 2 in Molecular Pharmacology
Sep 1972 - Jul 1976
École Nationale Vétérinaire de Maisons-Alfort
Vétérinaire
Sep 1971 - Sep 1975
Paris Descartes University
Dr in pharmaceutical sciences
biological sciences, section

Experience

Jul 2019
Fondation pour la Recherche Médicale
president of the scientific council
Environnement and health grants
Jun 2019
Ecophyto 2 programme
member of the scientific council
agriculture, pesticides
Sep 2018
INSERM expertise collective "pesticides et santé"
member
2018-2020
Sep 2018
Mutuelle Sociale Agricole
president of the scientific council
Oct 2017
Conseil prévention et précaution-ministry of ecology
member
Sep 2012
Anses
expert
CES Reach
Jan 2011
INRA Centre de Toulouse Midi-Pyrénées and University of Toulouse
Head of Toxalim
2011-2018- Research unit on food contaminants toxicology
Jan 2009 - Jan 2009
INRA Centre de Toulouse Midi-Pyrénées
Head of UR 66-Pharmacology and Toxicology
2009-2010
Feb 2003
LBNL, Berkeley
Invited Prof
8 months-Life Sci Div, D Chen's group
Mar 2002
LBNL, Berkeley
Invited Prof
7 months-Life Sci Div- D Chen's group
Oct 1980 - Aug 1991
Université Toulouse III - Paul Sabatier
Prof of Toxicology
1991-2018-faculty of pharmacy
Jan 1989
Inst Pharmacol and structural Biol, CNRS
group leader
1989-2010-DNA repair team
Jan 1985
Texas Medical School
invited Assist Prof
1985-1986 G Weinstock's group
Oct 1980 - Oct 1980
Université Toulouse III - Paul Sabatier
Ass Prof of mol biol and biochemistry
1980-1990-faculty of pharmacy

Publications

57Publications

726Reads

228Profile Views

209PubMed Central Citations

Relationship between faecal microbiota and plasma metabolome in rats fed NK603 and MON810 GM maize from the GMO90+ study.

Food Chem Toxicol 2019 Sep 3;131:110547. Epub 2019 Jun 3.

Gene Expression and Therapy Group, King's College London, Faculty of Life Sciences & Medicine, Department of Medical and Molecular Genetics, 8th Floor, Tower Wing, Guy's Hospital, Great Maze Pond, London, SE1 9RT, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2019.05.055DOI Listing
September 2019
15 Reads
2.895 Impact Factor

Exposure to the Fungicide Captan Induces DNA Base Alterations and Replicative Stress in Mammalian Cells.

Environ Mol Mutagen 2019 04 19;60(3):286-297. Epub 2018 Dec 19.

Toxalim (Research Centre in Food Toxicology), Université de Toulouse, INRA, ENVT, INP-Purpan, UPS, Toulouse, France.

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http://dx.doi.org/10.1002/em.22268DOI Listing
April 2019
27 Reads
2.630 Impact Factor

Cell resistance to the Cytolethal Distending Toxin involves an association of DNA repair mechanisms.

Sci Rep 2016 10 24;6:36022. Epub 2016 Oct 24.

INRA, UMR1331, Toxalim, Research Center in Food Toxicology, F-31027 Toulouse, France.

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http://dx.doi.org/10.1038/srep36022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075911PMC
October 2016
20 Reads
2 Citations
5.078 Impact Factor

Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells.

J Cell Sci 2016 07 20;129(13):2673-83. Epub 2016 May 20.

Toxalim, Université de Toulouse, INRA, Université de Toulouse 3 Paul Sabatier, 31027 Toulouse, France

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http://dx.doi.org/10.1242/jcs.183103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958301PMC
July 2016
18 Reads
4 Citations
5.432 Impact Factor

DNA damage in B and T lymphocytes of farmers during one pesticide spraying season.

Int Arch Occup Environ Health 2015 Oct 3;88(7):963-72. Epub 2015 Feb 3.

INRA, UMR 1331, Toxalim, Research Centre in Food Toxicology, 31027, Toulouse, France.

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http://dx.doi.org/10.1007/s00420-015-1024-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564440PMC
October 2015
5 Reads
2.198 Impact Factor

A new phosphorylated form of Ku70 identified in resistant leukemic cells confers fast but unfaithful DNA repair in cancer cell lines.

Oncotarget 2015 Sep;6(29):27980-8000

Laboratoire de Cancérologie Expérimentale, Institut de Radiobiologie Cellulaire et Moléculaire (IRCM), Commissariat à l'Energie Atomique et aux Energies Renouvelables (CEA), 92265 Fontenay aux Roses, France.

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http://dx.doi.org/10.18632/oncotarget.4735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695039PMC
September 2015
38 Reads
6.359 Impact Factor

Facilitating a transparent and tailored scientific discussion about the added value of animal feeding trials as well as in vitro and in silico approaches with whole food/feed for the risk assessment of genetically modified plants.

Arch Toxicol 2014 Dec 2;88(12):2067-9. Epub 2014 Oct 2.

Institute for Biosafety in Plant Biotechnology, Julius Kühn-Institut, Federal Research Centre for Cultivated Plants, Erwin-Baur-Str. 27, 06484, Quedlinburg, Germany,

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http://dx.doi.org/10.1007/s00204-014-1375-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247473PMC
December 2014
3 Reads
5.980 Impact Factor

RECQ helicase RECQL4 participates in non-homologous end joining and interacts with the Ku complex.

Carcinogenesis 2014 Nov 18;35(11):2415-24. Epub 2014 Jun 18.

Laboratory of Molecular Gerontology, Biomedical Research Center, National Institute on Aging, NIH, 251 Bayview Boulevard, Baltimore, MD 21224, USA, INRA, Université de Toulouse, UMR1331, Toxalim, Research Centre in Food Toxicology, F-31027 Toulouse, France and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark

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http://dx.doi.org/10.1093/carcin/bgu137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216052PMC
November 2014
35 Reads
6 Citations
5.334 Impact Factor

DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal.

Nucleic Acids Res 2014 Aug 16;42(14):9047-62. Epub 2014 Jul 16.

CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), BP 64182, 205 route de Narbonne, F-31077 Toulouse, Cedex 4, France Université de Toulouse, UPS, IPBS, F-31077 Toulouse, France Equipe Labellisée Ligue Nationale Contre le Cancer

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http://dx.doi.org/10.1093/nar/gku601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132723PMC
August 2014
19 Reads
37 Citations
9.112 Impact Factor

Ionizing-radiation induced DNA double-strand breaks: a direct and indirect lighting up.

Radiother Oncol 2013 Sep 9;108(3):362-9. Epub 2013 Jul 9.

INRA, UMR1331, Université de Toulouse, TOXALIM (Research Centre in Food Toxicology), F-31027 Toulouse, France.

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http://dx.doi.org/10.1016/j.radonc.2013.06.013DOI Listing
September 2013
6 Reads
24 Citations
4.363 Impact Factor

DNA-PK, a Pharmacological Target in Cancer Chemotherapy and Radiotherapy?

Volume 72, pp 25-44

Advances in DNA repair in Cancer Therapy

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July 2013
6 Reads

A noncatalytic function of the ligation complex during nonhomologous end joining.

J Cell Biol 2013 Jan;200(2):173-86

Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse F-31077, Cedex 4, France.

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http://dx.doi.org/10.1083/jcb.201203128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549972PMC
January 2013
8 Reads
9.834 Impact Factor

Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks.

Nucleic Acids Res 2011 Dec 31;39(22):9605-19. Epub 2011 Aug 31.

CNRS, Institut de Pharmacologie et de Biologie Structurale, F-31077 Toulouse, France.

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http://dx.doi.org/10.1093/nar/gkr656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239177PMC
December 2011
73 Reads
9.112 Impact Factor

Cancer-associated adipocytes promotes breast tumor radioresistance.

Biochem Biophys Res Commun 2011 Jul 25;411(1):102-6. Epub 2011 Jun 25.

Université de Toulouse, UPS, F-31077 Toulouse Cedex, France.

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http://dx.doi.org/10.1016/j.bbrc.2011.06.101DOI Listing
July 2011
6 Reads
2.297 Impact Factor

A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia.

J Cell Sci 2011 Jun;124(Pt 11):1943-51

CNRS-IPBS (Institut de Pharmacologie et de Biologie Structurale), 205 route de Narbonne, F-31077 Toulouse, France.

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http://dx.doi.org/10.1242/jcs.078030DOI Listing
June 2011
8 Reads
5.432 Impact Factor

A G-quadruplex structure within the 5'-UTR of TRF2 mRNA represses translation in human cells.

Nucleic Acids Res 2010 Nov 22;38(20):7187-98. Epub 2010 Jun 22.

CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), 205 route de Narbonne, 31077 Toulouse, Université de Toulouse, UPS, IPBS, F-31077 Toulouse, France.

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http://dx.doi.org/10.1093/nar/gkq563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978344PMC
November 2010
19 Reads
9.112 Impact Factor

TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends.

EMBO J 2010 May 20;29(9):1573-84. Epub 2010 Apr 20.

Institut de Pharmacologie et de Biologie Structurale, Toulouse, France.

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http://dx.doi.org/10.1038/emboj.2010.49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876953PMC
May 2010
5 Reads
10.434 Impact Factor

Cell nonhomologous end joining capacity controls SAF-A phosphorylation by DNA-PK in response to DNA double-strand breaks inducers.

Cell Cycle 2009 Nov 9;8(22):3717-22. Epub 2009 Nov 9.

CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France; Université de Toulouse, UPS, IPBS, Toulouse, France.

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http://dx.doi.org/10.4161/cc.8.22.10025DOI Listing
November 2009
6 Reads
17 Citations

ARTEMIS nuclease facilitates apoptotic chromatin cleavage.

Cancer Res 2009 Oct 6;69(20):8120-6. Epub 2009 Oct 6.

CNRS, Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, UPS, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-4400DOI Listing
October 2009
7 Reads
5 Citations
9.329 Impact Factor

Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4.

Mol Cell Biol 2009 Jun 30;29(11):3163-72. Epub 2009 Mar 30.

CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France.

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http://dx.doi.org/10.1128/MCB.01895-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682001PMC
June 2009
7 Reads
47 Citations
4.777 Impact Factor

Effect of double-strand break DNA sequence on the PARP-1 NHEJ pathway.

Biochem Biophys Res Commun 2008 May 3;369(3):982-8. Epub 2007 Dec 3.

Institut de Pharmacologie et de Biologie Structurale, CNRS UMR5089, 205 route de Narbonne, F-31077 Toulouse, Cedex, France.

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http://dx.doi.org/10.1016/j.bbrc.2007.11.132DOI Listing
May 2008
10 Reads
2.297 Impact Factor

Cell-surface MMP-9 regulates the invasive capacity of leukemia blast cells with monocytic features.

Cell Cycle 2008 Apr 18;7(8):1047-53. Epub 2008 Jan 18.

Institut de Pharmacologie et de Biologie Structurale, Université Toulouse/CNRS UMR 5089, Toulouse, France.

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http://dx.doi.org/10.4161/cc.7.8.5645DOI Listing
April 2008
38 Reads
5 Citations

DNA repair, damage signaling and carcinogenesis.

DNA Repair (Amst) 2008 Apr 24;7(4):670-80. Epub 2008 Jan 24.

Institut Gustave Roussy, CNRS - UMR 8126, Villejuif, France.

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http://dx.doi.org/10.1016/j.dnarep.2007.12.007DOI Listing
April 2008
2 Reads

c-MYC protein is degraded in response to UV irradiation.

Cell Cycle 2008 Jan 2;7(1):63-70. Epub 2007 Oct 2.

Institut de Pharmacologie et de Biologie Structurale, CNRS-Université de Toulouse, Toulouse, France.

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http://dx.doi.org/10.4161/cc.7.1.5111DOI Listing
January 2008
1 Read

Interplay between Cernunnos-XLF and nonhomologous end-joining proteins at DNA ends in the cell.

J Biol Chem 2007 Nov 24;282(44):31937-43. Epub 2007 Aug 24.

Institut de Pharmacologie et de Biologie Structurale, CNRS-Université de Toulouse, UMR 5089, Toulouse, and INSERM, Hôpital Necker-Enfants Malades, U768, Unité Développement Normal et Pathologique du Système Immunitaire, F-75015 Paris, France.

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http://dx.doi.org/10.1074/jbc.M704554200DOI Listing
November 2007
5 Reads
4.573 Impact Factor

Transport of the leaderless protein Ku on the cell surface of activated monocytes regulates their migratory abilities.

EMBO Rep 2007 Jun 11;8(6):583-8. Epub 2007 May 11.

Institut de Pharmacologie et de Biologie Structurale, CNRS UMR 5089, 205 Route de Narbonne, 31077 Toulouse cedex, France.

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http://dx.doi.org/10.1038/sj.embor.7400976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2002536PMC
June 2007
3 Reads
9.055 Impact Factor

Long-term XPC silencing reduces DNA double-strand break repair.

Cancer Res 2007 Mar;67(6):2526-34

Commissariat à l'Energie Atomique, Laboratoire de Génétique de la Radiosensibilité, Département de Radiobiologie et de Radiopathologie, Direction des Sciences du Vivant, Fontenay-aux-Roses, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-3371DOI Listing
March 2007
25 Reads
9.329 Impact Factor

Interplay between Ku, Artemis, and the DNA-dependent protein kinase catalytic subunit at DNA ends.

J Biol Chem 2006 Sep 19;281(38):27784-93. Epub 2006 Jul 19.

Institut de Pharmacologie et de Biologie Structurale, CNRS UMR 5089, 205 Route de Narbonne, 31077 Toulouse, Cedex 4, France.

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http://dx.doi.org/10.1074/jbc.M603047200DOI Listing
September 2006
4 Reads
4.573 Impact Factor

The loss of gammaH2AX signal is a marker of DNA double strand breaks repair only at low levels of DNA damage.

Cell Cycle 2006 May 15;5(10):1116-22. Epub 2006 May 15.

Institut de Pharmacologie et de Biologie Structurale, CNRS/University Paul Sabatier Toulouse III UMR 5089, Toulouse, France.

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http://dx.doi.org/10.4161/cc.5.10.2799DOI Listing
May 2006
5 Reads

Involvement of polynucleotide kinase in a poly(ADP-ribose) polymerase-1-dependent DNA double-strand breaks rejoining pathway.

J Mol Biol 2006 Feb 28;356(2):257-65. Epub 2005 Nov 28.

Institut de Pharmacologie et de Biologie Structurale, CNRS UMR 5089, Toulouse, France.

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http://dx.doi.org/10.1016/j.jmb.2005.11.028DOI Listing
February 2006
24 Reads
4.333 Impact Factor

Human chronic lymphocytic leukemia B cells can escape DNA damage-induced apoptosis through the nonhomologous end-joining DNA repair pathway.

Blood 2005 Jun 17;105(12):4776-83. Epub 2005 Feb 17.

Laboratoire de Radiobiologie et Oncologie, Commissariat à l'Enegie Atomique, Fontenay-aux-Roses, France.

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http://dx.doi.org/10.1182/blood-2004-07-2888DOI Listing
June 2005
48 Reads
10.452 Impact Factor

hMutS alpha is protected from ubiquitin-proteasome-dependent degradation by atypical protein kinase C zeta phosphorylation.

J Mol Biol 2005 Apr;348(1):63-74

INSERM U563, CPTP, Bat B, Pavillon Lefebvre, Place du Dr Baylac, CHU PURPAN, BP 3028, 31024 Toulouse cedex 3, France.

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http://dx.doi.org/10.1016/j.jmb.2005.02.001DOI Listing
April 2005
13 Reads
4.333 Impact Factor

The double life of the Ku protein: facing the DNA breaks and the extracellular environment.

Cell Cycle 2005 Mar 31;4(3):438-41. Epub 2005 Mar 31.

Institut de Pharmacologie et de Biologie Structurale, CNRS UMR 5089, Toulouse Cedex, France.

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http://dx.doi.org/10.4161/cc.4.3.1565DOI Listing
March 2005
4 Reads

DNA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks.

J Biol Chem 2005 Feb 31;280(8):7060-9. Epub 2004 Oct 31.

Institut de Pharmacologie et de Biologie Structurale, CNRS UMR 5089, 205 route de Narbonne, 31077 Toulouse, Cedex 4, France.

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http://dx.doi.org/10.1074/jbc.M410746200DOI Listing
February 2005
9 Reads
4.573 Impact Factor

Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.

J Biol Chem 2004 Dec 21;279(53):55117-26. Epub 2004 Oct 21.

Institut de Pharmacologie et de Biologie Structurale, CNRS UMR 5089, 205 route de Narbonne, F-31077 Toulouse Cedex, France.

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http://dx.doi.org/10.1074/jbc.M404524200DOI Listing
December 2004
10 Reads
4.573 Impact Factor

The membrane form of the DNA repair protein Ku interacts at the cell surface with metalloproteinase 9.

EMBO J 2004 Oct 23;23(19):3758-68. Epub 2004 Sep 23.

Institut de Pharmacologie et de Biologie Structurale, CNRS UMR 5089, Toulouse, France.

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http://dx.doi.org/10.1038/sj.emboj.7600403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC522801PMC
October 2004
4 Reads
10.434 Impact Factor

Degadration of mismatch repair hMutSalpha heterodimer by the ubiquitin-proteasome pathway.

FEBS Lett 2004 Mar;562(1-3):40-4

INSERM U563, Centre de Physiopathologie Toulouse Purpan, Institut Claudius Regaud, 20 rue du Pont Saint-Pierre, 31052 Toulouse, France.

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http://dx.doi.org/10.1016/S0014-5793(04)00181-4DOI Listing
March 2004
2 Reads
3.169 Impact Factor

The Membrane-associated form of the DNA repair protein Ku is involved in cell adhesion to fibronectin.

J Mol Biol 2004 Mar;337(3):503-11

Institut de Pharmacologie et de Biologie Structurale, CNRS UMR 5089, 205 route de Narbonne, 31077 Toulouse Cedex, France.

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http://dx.doi.org/10.1016/j.jmb.2004.01.057DOI Listing
March 2004
2 Reads
4.333 Impact Factor

Possible anti-recombinogenic role of Bloom's syndrome helicase in double-strand break processing.

Nucleic Acids Res 2003 Nov;31(21):6272-82

Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8126, Institut Gustave Roussy, 39 Rue Camille Desmoulins, 94805 Villejuif Cedex, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC275476PMC
http://dx.doi.org/10.1093/nar/gkg834DOI Listing
November 2003
3 Reads
9.112 Impact Factor

hMSH2 expression is driven by AP1-dependent regulation through phorbol-ester exposure.

Nucleic Acids Res 2003 Oct;31(19):5627-34

Institut de Pharmacologie et de Biologie Structurale, UMR 5089 CNRS, 205, Route de Narbonne, 31077, Toulouse Cedex, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC206476PMC
http://dx.doi.org/10.1093/nar/gkg781DOI Listing
October 2003
2 Reads
9.112 Impact Factor

Long-patch DNA repair synthesis during base excision repair in mammalian cells.

EMBO Rep 2003 Apr;4(4):363-7

Institut de Pharmacologie et Ciologie Structurale, CNRS UMR, Toulouse, France.

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http://dx.doi.org/10.1038/sj.embor.embor796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1319152PMC
April 2003
4 Reads
9.055 Impact Factor

Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment.

J Mol Biol 2003 Feb;326(1):93-103

Institut de Pharmacologie et de Biologie Structurale, CNRS UMR 5089, 205 route de Narbonne, 31077, Cedex 4, Toulouse, France.

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http://dx.doi.org/10.1016/s0022-2836(02)01328-1DOI Listing
February 2003
3 Reads
4.333 Impact Factor

Transcriptional activators stimulate DNA repair.

Mol Cell 2002 Dec;10(6):1391-401

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, B.P.163, 67404 Cedex, Illkirch, France.

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http://dx.doi.org/10.1016/s1097-2765(02)00732-3DOI Listing
December 2002
4 Reads
17 Citations
14.018 Impact Factor

The radioprotective effect of the 24 kDa FGF-2 isoform in HeLa cells is related to an increased expression and activity of the DNA dependent protein kinase (DNA-PK) catalytic subunit.

Oncogene 2002 Sep;21(42):6471-9

Oncologie Cellulaire et Moléculaire, INSERM U563, Département d'Innovation thérapeutique et Oncologie Moléculaire, Centre de Lutte Contre le Cancer Claudius Regaud, 20-24 rue du Pont St Pierre, 31052 Toulouse Cedex France.

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http://dx.doi.org/10.1038/sj.onc.1205838DOI Listing
September 2002
6 Reads
12 Citations
8.459 Impact Factor

Kit signaling inhibits the sphingomyelin-ceramide pathway through PLC gamma 1: implication in stem cell factor radioprotective effect.

Blood 2002 Aug;100(4):1294-301

Institut Nationale de la Santé et de la Recherche Médicale E9910, Institut Claudius Régaud, Toulouse, France.

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August 2002
11 Reads
11 Citations
10.452 Impact Factor

Implication of protein kinase C in the regulation of DNA mismatch repair protein expression and function.

J Biol Chem 2002 May 5;277(20):18061-8. Epub 2002 Mar 5.

Institut de Pharmacologie et de Biologie Structurale, UMR 5089, CNRS, 205 route de Narbonne, 31077 Toulouse cedex, France.

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http://dx.doi.org/10.1074/jbc.M103451200DOI Listing
May 2002
3 Reads
8 Citations
4.573 Impact Factor

Investigations on the effects of oltipraz on the nucleotide excision repair in the liver.

Biochem Pharmacol 2002 Feb;63(4):745-9

INSERM U456, Détoxication et Réparation Tissulaire, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Rennes I, 2 avenue Léon Bernard, 35043 cédex, Rennes, France.

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http://dx.doi.org/10.1016/s0006-2952(01)00906-6DOI Listing
February 2002
5 Reads
5.009 Impact Factor