Bernard Keavney

Bernard Keavney

UNVERIFIED PROFILE

Are you Bernard Keavney?   Register this Author

Register author
Bernard Keavney

Bernard Keavney

Publications by authors named "Bernard Keavney"

Are you Bernard Keavney?   Register this Author

100Publications

3528Reads

28Profile Views

Does rhythm matter in acute heart failure? An insight from the British Society for Heart Failure National Audit.

Clin Res Cardiol 2019 Apr 8. Epub 2019 Apr 8.

Keele Cardiovascular Research Group, Centre for Prognosis Research, Institute for Primary Care and Health Sciences, University of Keele and Royal Stoke Hospital, Stoke-on-Trent, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00392-019-01463-5DOI Listing
April 2019

Chicken or Egg in the UK Biobank?

Authors:
Bernard Keavney

Circ Res 2019 Mar;124(6):830-831

From the British Heart Foundation Professor of Cardiovascular Medicine, The University of Manchester, United Kingdom; and Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.119.314756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420132PMC
March 2019

Global birth prevalence of congenital heart defects 1970-2017: updated systematic review and meta-analysis of 260 studies.

Int J Epidemiol 2019 Feb 19. Epub 2019 Feb 19.

Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

View Article

Download full-text PDF

Source
https://academic.oup.com/ije/advance-article/doi/10.1093/ije
Publisher Site
http://dx.doi.org/10.1093/ije/dyz009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469300PMC
February 2019

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

Authors:
Evangelos Evangelou Helen R Warren David Mosen-Ansorena Borbala Mifsud Raha Pazoki He Gao Georgios Ntritsos Niki Dimou Claudia P Cabrera Ibrahim Karaman Fu Liang Ng Marina Evangelou Katarzyna Witkowska Evan Tzanis Jacklyn N Hellwege Ayush Giri Digna R Velez Edwards Yan V Sun Kelly Cho J Michael Gaziano Peter W F Wilson Philip S Tsao Csaba P Kovesdy Tonu Esko Reedik Mägi Lili Milani Peter Almgren Thibaud Boutin Stéphanie Debette Jun Ding Franco Giulianini Elizabeth G Holliday Anne U Jackson Ruifang Li-Gao Wei-Yu Lin Jian'an Luan Massimo Mangino Christopher Oldmeadow Bram Peter Prins Yong Qian Muralidharan Sargurupremraj Nabi Shah Praveen Surendran Sébastien Thériault Niek Verweij Sara M Willems Jing-Hua Zhao Philippe Amouyel John Connell Renée de Mutsert Alex S F Doney Martin Farrall Cristina Menni Andrew D Morris Raymond Noordam Guillaume Paré Neil R Poulter Denis C Shields Alice Stanton Simon Thom Gonçalo Abecasis Najaf Amin Dan E Arking Kristin L Ayers Caterina M Barbieri Chiara Batini Joshua C Bis Tineka Blake Murielle Bochud Michael Boehnke Eric Boerwinkle Dorret I Boomsma Erwin P Bottinger Peter S Braund Marco Brumat Archie Campbell Harry Campbell Aravinda Chakravarti John C Chambers Ganesh Chauhan Marina Ciullo Massimiliano Cocca Francis Collins Heather J Cordell Gail Davies Martin H de Borst Eco J de Geus Ian J Deary Joris Deelen Fabiola Del Greco M Cumhur Yusuf Demirkale Marcus Dörr Georg B Ehret Roberto Elosua Stefan Enroth A Mesut Erzurumluoglu Teresa Ferreira Mattias Frånberg Oscar H Franco Ilaria Gandin Paolo Gasparini Vilmantas Giedraitis Christian Gieger Giorgia Girotto Anuj Goel Alan J Gow Vilmundur Gudnason Xiuqing Guo Ulf Gyllensten Anders Hamsten Tamara B Harris Sarah E Harris Catharina A Hartman Aki S Havulinna Andrew A Hicks Edith Hofer Albert Hofman Jouke-Jan Hottenga Jennifer E Huffman Shih-Jen Hwang Erik Ingelsson Alan James Rick Jansen Marjo-Riitta Jarvelin Roby Joehanes Åsa Johansson Andrew D Johnson Peter K Joshi Pekka Jousilahti J Wouter Jukema Antti Jula Mika Kähönen Sekar Kathiresan Bernard D Keavney Kay-Tee Khaw Paul Knekt Joanne Knight Ivana Kolcic Jaspal S Kooner Seppo Koskinen Kati Kristiansson Zoltan Kutalik Maris Laan Marty Larson Lenore J Launer Benjamin Lehne Terho Lehtimäki David C M Liewald Li Lin Lars Lind Cecilia M Lindgren YongMei Liu Ruth J F Loos Lorna M Lopez Yingchang Lu Leo-Pekka Lyytikäinen Anubha Mahajan Chrysovalanto Mamasoula Jaume Marrugat Jonathan Marten Yuri Milaneschi Anna Morgan Andrew P Morris Alanna C Morrison Peter J Munson Mike A Nalls Priyanka Nandakumar Christopher P Nelson Teemu Niiranen Ilja M Nolte Teresa Nutile Albertine J Oldehinkel Ben A Oostra Paul F O'Reilly Elin Org Sandosh Padmanabhan Walter Palmas Aarno Palotie Alison Pattie Brenda W J H Penninx Markus Perola Annette Peters Ozren Polasek Peter P Pramstaller Quang Tri Nguyen Olli T Raitakari Meixia Ren Rainer Rettig Kenneth Rice Paul M Ridker Janina S Ried Harriëtte Riese Samuli Ripatti Antonietta Robino Lynda M Rose Jerome I Rotter Igor Rudan Daniela Ruggiero Yasaman Saba Cinzia F Sala Veikko Salomaa Nilesh J Samani Antti-Pekka Sarin Reinhold Schmidt Helena Schmidt Nick Shrine David Siscovick Albert V Smith Harold Snieder Siim Sõber Rossella Sorice John M Starr David J Stott David P Strachan Rona J Strawbridge Johan Sundström Morris A Swertz Kent D Taylor Alexander Teumer Martin D Tobin Maciej Tomaszewski Daniela Toniolo Michela Traglia Stella Trompet Jaakko Tuomilehto Christophe Tzourio André G Uitterlinden Ahmad Vaez Peter J van der Most Cornelia M van Duijn Anne-Claire Vergnaud Germaine C Verwoert Veronique Vitart Uwe Völker Peter Vollenweider Dragana Vuckovic Hugh Watkins Sarah H Wild Gonneke Willemsen James F Wilson Alan F Wright Jie Yao Tatijana Zemunik Weihua Zhang John R Attia Adam S Butterworth Daniel I Chasman David Conen Francesco Cucca John Danesh Caroline Hayward Joanna M M Howson Markku Laakso Edward G Lakatta Claudia Langenberg Olle Melander Dennis O Mook-Kanamori Colin N A Palmer Lorenz Risch Robert A Scott Rodney J Scott Peter Sever Tim D Spector Pim van der Harst Nicholas J Wareham Eleftheria Zeggini Daniel Levy Patricia B Munroe Christopher Newton-Cheh Morris J Brown Andres Metspalu Adriana M Hung Christopher J O'Donnell Todd L Edwards Bruce M Psaty Ioanna Tzoulaki Michael R Barnes Louise V Wain Paul Elliott Mark J Caulfield

Nat Genet 2018 12;50(12):1755

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41588-018-0297-3
Publisher Site
http://dx.doi.org/10.1038/s41588-018-0297-3DOI Listing
December 2018

Structural modelling of the cardiovascular system.

Biomech Model Mechanobiol 2018 Oct 18;17(5):1217-1242. Epub 2018 Jun 18.

School of Mechanical, Aerospace and Civil Engineering, University of Manchester, George Begg Building, Manchester, M1 3BB, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10237-018-1024-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154127PMC
October 2018

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

Authors:
Evangelos Evangelou Helen R Warren David Mosen-Ansorena Borbala Mifsud Raha Pazoki He Gao Georgios Ntritsos Niki Dimou Claudia P Cabrera Ibrahim Karaman Fu Liang Ng Marina Evangelou Katarzyna Witkowska Evan Tzanis Jacklyn N Hellwege Ayush Giri Digna R Velez Edwards Yan V Sun Kelly Cho J Michael Gaziano Peter W F Wilson Philip S Tsao Csaba P Kovesdy Tonu Esko Reedik Mägi Lili Milani Peter Almgren Thibaud Boutin Stéphanie Debette Jun Ding Franco Giulianini Elizabeth G Holliday Anne U Jackson Ruifang Li-Gao Wei-Yu Lin Jian'an Luan Massimo Mangino Christopher Oldmeadow Bram Peter Prins Yong Qian Muralidharan Sargurupremraj Nabi Shah Praveen Surendran Sébastien Thériault Niek Verweij Sara M Willems Jing-Hua Zhao Philippe Amouyel John Connell Renée de Mutsert Alex S F Doney Martin Farrall Cristina Menni Andrew D Morris Raymond Noordam Guillaume Paré Neil R Poulter Denis C Shields Alice Stanton Simon Thom Gonçalo Abecasis Najaf Amin Dan E Arking Kristin L Ayers Caterina M Barbieri Chiara Batini Joshua C Bis Tineka Blake Murielle Bochud Michael Boehnke Eric Boerwinkle Dorret I Boomsma Erwin P Bottinger Peter S Braund Marco Brumat Archie Campbell Harry Campbell Aravinda Chakravarti John C Chambers Ganesh Chauhan Marina Ciullo Massimiliano Cocca Francis Collins Heather J Cordell Gail Davies Martin H de Borst Eco J de Geus Ian J Deary Joris Deelen Fabiola Del Greco M Cumhur Yusuf Demirkale Marcus Dörr Georg B Ehret Roberto Elosua Stefan Enroth A Mesut Erzurumluoglu Teresa Ferreira Mattias Frånberg Oscar H Franco Ilaria Gandin Paolo Gasparini Vilmantas Giedraitis Christian Gieger Giorgia Girotto Anuj Goel Alan J Gow Vilmundur Gudnason Xiuqing Guo Ulf Gyllensten Anders Hamsten Tamara B Harris Sarah E Harris Catharina A Hartman Aki S Havulinna Andrew A Hicks Edith Hofer Albert Hofman Jouke-Jan Hottenga Jennifer E Huffman Shih-Jen Hwang Erik Ingelsson Alan James Rick Jansen Marjo-Riitta Jarvelin Roby Joehanes Åsa Johansson Andrew D Johnson Peter K Joshi Pekka Jousilahti J Wouter Jukema Antti Jula Mika Kähönen Sekar Kathiresan Bernard D Keavney Kay-Tee Khaw Paul Knekt Joanne Knight Ivana Kolcic Jaspal S Kooner Seppo Koskinen Kati Kristiansson Zoltan Kutalik Maris Laan Marty Larson Lenore J Launer Benjamin Lehne Terho Lehtimäki David C M Liewald Li Lin Lars Lind Cecilia M Lindgren YongMei Liu Ruth J F Loos Lorna M Lopez Yingchang Lu Leo-Pekka Lyytikäinen Anubha Mahajan Chrysovalanto Mamasoula Jaume Marrugat Jonathan Marten Yuri Milaneschi Anna Morgan Andrew P Morris Alanna C Morrison Peter J Munson Mike A Nalls Priyanka Nandakumar Christopher P Nelson Teemu Niiranen Ilja M Nolte Teresa Nutile Albertine J Oldehinkel Ben A Oostra Paul F O'Reilly Elin Org Sandosh Padmanabhan Walter Palmas Aarno Palotie Alison Pattie Brenda W J H Penninx Markus Perola Annette Peters Ozren Polasek Peter P Pramstaller Quang Tri Nguyen Olli T Raitakari Meixia Ren Rainer Rettig Kenneth Rice Paul M Ridker Janina S Ried Harriëtte Riese Samuli Ripatti Antonietta Robino Lynda M Rose Jerome I Rotter Igor Rudan Daniela Ruggiero Yasaman Saba Cinzia F Sala Veikko Salomaa Nilesh J Samani Antti-Pekka Sarin Reinhold Schmidt Helena Schmidt Nick Shrine David Siscovick Albert V Smith Harold Snieder Siim Sõber Rossella Sorice John M Starr David J Stott David P Strachan Rona J Strawbridge Johan Sundström Morris A Swertz Kent D Taylor Alexander Teumer Martin D Tobin Maciej Tomaszewski Daniela Toniolo Michela Traglia Stella Trompet Jaakko Tuomilehto Christophe Tzourio André G Uitterlinden Ahmad Vaez Peter J van der Most Cornelia M van Duijn Anne-Claire Vergnaud Germaine C Verwoert Veronique Vitart Uwe Völker Peter Vollenweider Dragana Vuckovic Hugh Watkins Sarah H Wild Gonneke Willemsen James F Wilson Alan F Wright Jie Yao Tatijana Zemunik Weihua Zhang John R Attia Adam S Butterworth Daniel I Chasman David Conen Francesco Cucca John Danesh Caroline Hayward Joanna M M Howson Markku Laakso Edward G Lakatta Claudia Langenberg Olle Melander Dennis O Mook-Kanamori Colin N A Palmer Lorenz Risch Robert A Scott Rodney J Scott Peter Sever Tim D Spector Pim van der Harst Nicholas J Wareham Eleftheria Zeggini Daniel Levy Patricia B Munroe Christopher Newton-Cheh Morris J Brown Andres Metspalu Adriana M Hung Christopher J O'Donnell Todd L Edwards Bruce M Psaty Ioanna Tzoulaki Michael R Barnes Louise V Wain Paul Elliott Mark J Caulfield

Nat Genet 2018 10 17;50(10):1412-1425. Epub 2018 Sep 17.

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41588-018-0205-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284793PMC
October 2018

Biochemical Screening for Nonadherence Is Associated With Blood Pressure Reduction and Improvement in Adherence.

Hypertension 2017 11 28;70(5):1042-1048. Epub 2017 Aug 28.

From the Department of Metabolic Medicine and Chemical Pathology, University Hospitals of Leicester NHS Trust, United Kingdom (P.G., P.P., G.S.G., P.R.S.); Department of Cardiovascular Sciences, University of Leicester, United Kingdom (P.G., P.P., F.Y.L., G.S.G., N.J.S.); National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, United Kingdom (P.G., P.P., F.Y.L., N.J.S.); Division of Cardiovascular Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, United Kingdom (P.G., A.A., B.K., A.H., M.T.); 3rd Department of Medicine, Department of Endocrinology and Metabolism, Hypertension Centre (B.S., J.W.) and Institute of Forensic Medicine and Toxicology (V.M.), General University Hospital, Charles University, Prague, Czech Republic; University of Leicester, United Kingdom (A.B.); University Hospitals of Leicester NHS Trust, United Kingdom (P.S.T., A.S., H.T.); Department of Health Psychology, University College of London, United Kingdom (R.H.); Division of Medicine, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, United Kingdom (B.K., A.H., M.T.); Institute of Cardiovascular Science, University College London, United Kingdom (B.W.); and National Institute for Health Research, University College London Hospitals Biomedical Research Centre, United Kingdom (B.W.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642335PMC
November 2017

Non-muscle myosin IIB (Myh10) is required for epicardial function and coronary vessel formation during mammalian development.

PLoS Genet 2017 Oct 30;13(10):e1007068. Epub 2017 Oct 30.

Division of Evolution and Genome Sciences, School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1007068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697871PMC
October 2017

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.

Authors:
Louise V Wain Ahmad Vaez Rick Jansen Roby Joehanes Peter J van der Most A Mesut Erzurumluoglu Paul F O'Reilly Claudia P Cabrera Helen R Warren Lynda M Rose Germaine C Verwoert Jouke-Jan Hottenga Rona J Strawbridge Tonu Esko Dan E Arking Shih-Jen Hwang Xiuqing Guo Zoltan Kutalik Stella Trompet Nick Shrine Alexander Teumer Janina S Ried Joshua C Bis Albert V Smith Najaf Amin Ilja M Nolte Leo-Pekka Lyytikäinen Anubha Mahajan Nicholas J Wareham Edith Hofer Peter K Joshi Kati Kristiansson Michela Traglia Aki S Havulinna Anuj Goel Mike A Nalls Siim Sõber Dragana Vuckovic Jian'an Luan Fabiola Del Greco M Kristin L Ayers Jaume Marrugat Daniela Ruggiero Lorna M Lopez Teemu Niiranen Stefan Enroth Anne U Jackson Christopher P Nelson Jennifer E Huffman Weihua Zhang Jonathan Marten Ilaria Gandin Sarah E Harris Tatijana Zemunik Yingchang Lu Evangelos Evangelou Nabi Shah Martin H de Borst Massimo Mangino Bram P Prins Archie Campbell Ruifang Li-Gao Ganesh Chauhan Christopher Oldmeadow Gonçalo Abecasis Maryam Abedi Caterina M Barbieri Michael R Barnes Chiara Batini John Beilby Tineka Blake Michael Boehnke Erwin P Bottinger Peter S Braund Morris Brown Marco Brumat Harry Campbell John C Chambers Massimiliano Cocca Francis Collins John Connell Heather J Cordell Jeffrey J Damman Gail Davies Eco J de Geus Renée de Mutsert Joris Deelen Yusuf Demirkale Alex S F Doney Marcus Dörr Martin Farrall Teresa Ferreira Mattias Frånberg He Gao Vilmantas Giedraitis Christian Gieger Franco Giulianini Alan J Gow Anders Hamsten Tamara B Harris Albert Hofman Elizabeth G Holliday Jennie Hui Marjo-Riitta Jarvelin Åsa Johansson Andrew D Johnson Pekka Jousilahti Antti Jula Mika Kähönen Sekar Kathiresan Kay-Tee Khaw Ivana Kolcic Seppo Koskinen Claudia Langenberg Marty Larson Lenore J Launer Benjamin Lehne David C M Liewald Li Lin Lars Lind François Mach Chrysovalanto Mamasoula Cristina Menni Borbala Mifsud Yuri Milaneschi Anna Morgan Andrew D Morris Alanna C Morrison Peter J Munson Priyanka Nandakumar Quang Tri Nguyen Teresa Nutile Albertine J Oldehinkel Ben A Oostra Elin Org Sandosh Padmanabhan Aarno Palotie Guillaume Paré Alison Pattie Brenda W J H Penninx Neil Poulter Peter P Pramstaller Olli T Raitakari Meixia Ren Kenneth Rice Paul M Ridker Harriëtte Riese Samuli Ripatti Antonietta Robino Jerome I Rotter Igor Rudan Yasaman Saba Aude Saint Pierre Cinzia F Sala Antti-Pekka Sarin Reinhold Schmidt Rodney Scott Marc A Seelen Denis C Shields David Siscovick Rossella Sorice Alice Stanton David J Stott Johan Sundström Morris Swertz Kent D Taylor Simon Thom Ioanna Tzoulaki Christophe Tzourio André G Uitterlinden Uwe Völker Peter Vollenweider Sarah Wild Gonneke Willemsen Alan F Wright Jie Yao Sébastien Thériault David Conen John Attia Peter Sever Stéphanie Debette Dennis O Mook-Kanamori Eleftheria Zeggini Tim D Spector Pim van der Harst Colin N A Palmer Anne-Claire Vergnaud Ruth J F Loos Ozren Polasek John M Starr Giorgia Girotto Caroline Hayward Jaspal S Kooner Cecila M Lindgren Veronique Vitart Nilesh J Samani Jaakko Tuomilehto Ulf Gyllensten Paul Knekt Ian J Deary Marina Ciullo Roberto Elosua Bernard D Keavney Andrew A Hicks Robert A Scott Paolo Gasparini Maris Laan YongMei Liu Hugh Watkins Catharina A Hartman Veikko Salomaa Daniela Toniolo Markus Perola James F Wilson Helena Schmidt Jing Hua Zhao Terho Lehtimäki Cornelia M van Duijn Vilmundur Gudnason Bruce M Psaty Annette Peters Rainer Rettig Alan James J Wouter Jukema David P Strachan Walter Palmas Andres Metspalu Erik Ingelsson Dorret I Boomsma Oscar H Franco Murielle Bochud Christopher Newton-Cheh Patricia B Munroe Paul Elliott Daniel I Chasman Aravinda Chakravarti Joanne Knight Andrew P Morris Daniel Levy Martin D Tobin Harold Snieder Mark J Caulfield Georg B Ehret

Hypertension 2017 Jul 24. Epub 2017 Jul 24.

From the Department of Health Sciences (L.V.W., A.M.E., N. Shrine, C.B., T.B., M.D.T.), and Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre (C.P.N., P.S.B., N.J.S.), University of Leicester, United Kingdom; Department of Epidemiology (A.V., P.J.v.d.M., I.M.N., H. Snieder), Division of Nephrology, Department of Internal Medicine (M.H.d.B., M.A.S.), Interdisciplinary Center Psychopathology and Emotion Regulation (IPCE) (A.J.O., H.R., C.A.H.), Department of Genetics, (M.S.), and Department of Cardiology (P.v.d.H.), University of Groningen, University Medical Center Groningen, The Netherlands; Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Iran (A.V.); Department of Psychiatry, VU University Medical Center, Neuroscience Campus Amsterdam, The Netherlands (R. Jansen); Hebrew SeniorLife, Harvard Medical School, Boston, MA (R. Joehanes); National Heart, Lung and Blood Institute's Framingham Heart Study, MA (R. Joehanes, A.D.J., M. Larson); Institute of Psychiatry, Psychology and Neuroscience (P.F.O.), and Department of Twin Research and Genetic Epidemiology (M.M., C. Menni, T.D.S.), King's College London, United Kingdom; Clinical Pharmacology, William Harvey Research Institute (C.P.C., H.R.W., M.R.B., M. Brown, B.M., M.R., P.B.M., M.J.C.) and NIHR Barts Cardiovascular Biomedical Research Unit (C.P.C., H.R.W., M.R.B., M. Brown, P.B.M., M.J.C.), Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA (L.M.R., F.G., P.M.R., D.I.C.); Department of Epidemiology (G.C.V., A. Hofman, A.G.U., O.H.F.), Genetic Epidemiology Unit, Department of Epidemiology (N.A., B.A.O., C.M.v.D.), and Department of Internal Medicine (A.G.U.), Erasmus MC, Rotterdam, The Netherlands; Department of Biological Psychology, Vrije Universiteit, Amsterdam, EMGO+ Institute, VU University Medical Center, The Netherlands (J.-J.H., E.J.d.G., G.W., D.I.B.); Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S., M. Frånberg, A. Hamsten); Centre for Molecular Medicine, Karolinska Universitetsjukhuset, Solna, Sweden (R.J.S., M. Frånberg, A. Hamsten); Estonian Genome Center (T.E., E.O., A. Metspalu), Institute of Biomedicine and Translational Medicine (S.S., M. Laan), and Estonian Genome Center (M.P.), University of Tartu, Estonia; Divisions of Endocrinology/Children's Hospital, Boston, MA (T.E.); Broad Institute of Harvard and MIT, Cambridge, MA (T.E., C.M.L., C.N.-C.); Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (D.E.A., P.N., A. Chakravarti, G.B.E.); The Population Science Branch, Division of Intramural Research, National Heart Lung and Blood Institute (S.-J.H., D.L.), Laboratory of Neurogenetics, National Institute on Aging (M.A.N.), Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute (F.C.), and Center for Information Technology (Y.D., P.J.M., Q.T.N.), National Institutes of Health, Bethesda, MD; The Framingham Heart Study, Framingham, MA (S.-J.H., D.L.); The Institute for Translational Genomics and Population Sciences, Department of Pediatrics (X.G., J.Y.), and The Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine (J.I.R.), LABioMed at Harbor-UCLA Medical Center, Torrance, CA; Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland (Z.K., M. Bochud); Swiss Institute of Bioinformatics, Lausanne, Switzerland (Z.K.); Department of Cardiology (S. Trompet, J.W.J.) Department of Gerontology and Geriatrics (S. Trompet), Department of Clinical Epidemiology (R.L.-G., R.d.M., D.O.M.-K.), Department of Molecular Epidemiology (J.D.), and Department of Public Health and Primary Care (D.O.M.-K.), Leiden University Medical Center, The Netherlands; Institute for Community Medicine (A.T.), Department of Internal Medicine B (M.D.), and Interfaculty Institute for Genetics and Functional Genomics (U.V.), University Medicine Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Germany (A.T., M.D., U.V.); Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany (J.S.R., A. Peters); Cardiovascular Health Research Unit, Department of Medicine (J.C.B., B.M.P.) and Departments of Biostatistics (K.R.), Epidemiology (B.M.P.), and Health Services (B.M.P.), University of Washington, Seattle; Icelandic Heart Association, Kopavogur, Iceland (A.V.S., V. Gudnason); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (A.V.S., V. Gudnason); Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (L.-P.L., T.L.); Department of Clinical Chemistry, Faculty of Medicine and Life Sciences, University of Tampere, Finland (L.-P.L., T.L.); Wellcome Trust Centre for Human Genetics (A. Mahajan, A.G., M. Farrall, T.F., C.M.L., H.W., A.P.M.), and Division of Cardiovascular Medicine, Radcliffe Department of Medicine (A.G., M. Farrall, H.W.), University of Oxford, United Kingdom; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, United Kingdom (N.J.W., J.L., C.L., R.J.F.L., R.A.S., J.H.Z.); Clinical Division of Neurogeriatrics, Department of Neurology (E.H., R. Schmidt), Institute of Medical Informatics, Statistics and Documentation (E.H.), and Department of Neurology (H. Schmidt), Medical University Graz, Austria; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics (P.K.J., H.C., I.R., S.W., J.F.W.), Centre for Cognitive Ageing and Cognitive Epidemiology (L.M.L., S.E.H., G.D., A.J.G., D.C.M.L., J.M.S., I.J.D.), Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine (A. Campbell), Generation Scotland, Centre for Genomic and Experimental Medicine (A. Campbell, S.P., C.H.), Department of Psychology (G.D., D.C.M.L., A. Pattie, I.J.D.), Alzheimer Scotland Dementia Research Centre (J.M.S.), and Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine (C.H.), University of Edinburgh, Scotland, United Kingdom; Department of Health (K.K., A.S.H., T. Niiranen, P.J., A.J., S. Koskinen, P.K., V.S., M.P.), and Chronic Disease Prevention Unit (J.T.), National Institute for Health and Welfare (THL), Helsinki, Finland; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy (M.T., C.M.B., C.F.S., D.T.); Data Tecnica International, Glen Echo, MD (M.A.N.); Medical Genetics, IRCCS-Burlo Garofolo Children Hospital, Trieste, Italy (D.V., G.G., P.G.); Department of Medical, Surgical and Health Sciences, University of Trieste, Italy (D.V., I.G., M. Brumat, M. Cocca, A. Morgan, G.G., P.G.); Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy (F.D.G.M., P.P.P., A.S.P., A.A.H.); Department of Genetics and Genomic Sciences (K.L.A.), The Charles Bronfman Institute for Personalized Medicine (Y.L., E.P.B., R.J.F.L.), and Mindich Child health Development Institute (R.J.F.L.), Icahn School of Medicine at Mount Sinai, New York; Cardiovascular Epidemiology and Genetics, IMIM, and CIBERCV, Barcelona, Spain (J. Marrugat, R.E.); Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Napoli, Italy (D.R., T. Nutile, R. Sorice, M. Ciullo); Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin (L.M.L.); UCD Conway Institute, Centre for Proteome Research (L.M.L.), and School of Medicine, Conway Institute (D.C.S.), University College Dublin, Belfield, Ireland; Department of Immunology, Genetics and Pathology, Uppsala Universitet, Science for Life Laboratory, Sweden (S.E., Å. Johansson, U.G.); Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor (A.U.J., M. Boehnke); NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester United Kingdom (C.P.N., P.S.B., N.J.S.); MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine (J.E.H., V.V., J. Marten, A.F.W., J.F.W.), and Medical Genetics Section, Centre for Genomic and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine (S.E.H.), University of Edinburgh, Western General Hospital, Scotland, United Kingdom; Department of Epidemiology and Biostatistics, School of Public Health (W.Z., E.E., J.C.C., H.G., B.L., I.T., A.-C.V.), MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health (M.-R.J., P.E.), School of Public Health (N.P.), International Centre for Circulatory Health (S. Thom), and National Heart and Lung Institute (P.S.), Imperial College London, United Kingdom; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Southall, United Kingdom (W.Z., J.C.C., J.S.K.); Department of Medical Biology, Faculty of Medicine, University of Split, Croatia (T.Z.); Department of Hygiene and Epidemiology, University of Ioannina Medical School, Greece (E.E.); Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Scotland, United Kingdom (N. Shah, A.S.F.D., C.N.A.P.); Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan (N. Shah); National Institute for Health Research Biomedical Research Centre, London, United Kingdom (M.M.); Department of Human Genetics, Wellcome Trust Sanger Institute, United Kingdom (B.P.P., E.Z.); INSERM U 1219, Bordeaux Population Health Center, France (G.C., C.T., S.D.); Bordeaux University, France (G.C., C.T., S.D.); Hunter Medical Research Institute, New Lambton, NSW, Australia (C.O., E.G.H., R. Scott, J.A.); Center for Statistical Genetics, Department of Biostatistics, Ann Arbor, MI (G.A.); Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Iran (M.A.); Busselton Population Medical Research Institute, Western Australia (J.B., J.H.); PathWest Laboratory Medicine of Western Australia, Nedlands (J.B., J.H.); School of Pathology and Laboratory Medicine (J.B., J.H.), School of Population and Global Health (J.H.), and School of Medicine and Pharmacology (A. James), The University of Western Australia, Nedlands; Imperial College Healthcare NHS Trust, London, United Kingdom (J.C.C., J.S.K.); University of Dundee, Ninewells Hospital & Medical School, United Kingdom (J.C.); Institute of Genetic Medicine (H.J.C.), and Institute of Health and Society (C. Mamasoula), Newcastle University, Newcastle upon Tyne, United Kingdom; Department of Pathology, Amsterdam Medical Center, The Netherlands (J.J.D.); Department of Numerical Analysis and Computer Science, Stockholm University, Sweden (M. Frånberg); Department of Public Health and Caring Sciences, Geriatrics, Uppsala, Sweden (V. Giedraitis); Helmholtz Zentrum Muenchen, Deutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH), Neuherberg, Germany (C.G.); Department of Psychology, School of Social Sciences, Heriot-Watt University, Edinburgh, United Kingdom (A.J.G.); Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging (T.B.H., L.J.L.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (A. Hofman); Center For Life-Course Health Research (M.-R.J.), and Biocenter Oulu (M.-R.J.), University of Oulu, Finland; Unit of Primary Care, Oulu University Hospital, Finland (M.-R.J.); National Heart, Lung and Blood Institute, Cardiovascular Epidemiology and Human Genomics Branch, Bethesda, MD (A.D.J.); Department of Clinical Physiology, Tampere University Hospital, Finland (M.K.); Department of Clinical Physiology, Faculty of Medicine and Life Sciences, University of Tampere, Finland (M.K.); Cardiovascular Research Center (S. Kathiresan, C.N.-C.); Center for Human Genetics (S. Kathiresan), and Center for Human Genetic Research (C.N.-C.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (S. Kathiresan, C.N.-C.); Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, United Kingdom (K.-T.K.); Department of Public Health, Faculty of Medicine, University of Split, Croatia (I.K., O.P.); Cardiology, Department of Specialties of Medicine, Geneva University Hospital, Switzerland (L. Lin, F.M., G.B.E.); Department of Medical Sciences, Cardiovascular Epidemiology (L. Lind, J.S.), and Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory (E.I.), Uppsala University, Sweden; Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands (Y.M., B.W.J.H.P.); School of Molecular, Genetic and Population Health Sciences, University of Edinburgh, Medical School, Teviot Place, Scotland, United Kingdom (A.D.M.); Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston (A.C.M.); British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (S.P.), and Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), University of Glasgow, United Kingdom; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland (A. Palotie, S.R., A.-P.S., M.P.); Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada (G.P., S. Thériault); Department of Neurology, General Central Hospital, Bolzano, Italy (P.P.P.); Department of Neurology, University of Lübeck, Germany (P.P.P.); Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Finland (O.T.R.); Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland (O.T.R.); Department of Cardiology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China (M.R.); Harvard Medical School, Boston, MA (P.M.R., D.I.C.); Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy (A.R.); Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Austria (Y.S., H. Schmidt); INSERM U1078, Etablissement Français du Sang, Brest Cedex, France (A.S.P.); Faculty of Health, University of Newcastle, Callaghan, NSW, Australia (R. Scott, J.A.); John Hunter Hospital, New Lambton, NSW, Australia (R. Scott, J.A.); The New York Academy of Medicine, New York (D.S.); IRCCS Neuromed, Pozzilli, Isernia, Italy (R. Sorice, M. Ciullo); Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland (A.S.); Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA (K.D.T.); Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA (K.D.T.); Department of Public Health (C.T.), and Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Internal Medicine, Lausanne University Hospital, CHUV, Switzerland (P.V.); Population Health Research Institute, McMaster University, Hamilton Ontario, Canada (D.C.); National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, United Kingdom (J.S.K.); Dasman Diabetes Institute, Kuwait (J.T.); Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia (J.T.); Department of Neurosciences and Preventive Medicine, Danube-University Krems, Austria (J.T.); Division of Cardiovascular Sciences, The University of Manchester and Central Manchester University Hospitals NHS Foundation Trust, United Kingdom (B.D.K.); Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem (Y.M.L.); Kaiser Permanent Washington Health Research Institute, Seattle, WA (B.M.P.); Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany (R.R); Department of Pulmonary Physiology and Sleep, Sir Charles Gairdner Hospital, Nedlands, Western Australia (A. James); Population Health Research Institute, St George's, University of London, United Kingdom (D.P.S.); Department of Medicine, Columbia University Medical Center, New York (W.P.); Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, CA (E.I.); Data Science Institute and Lancaster Medical School, Lancaster University, United Kingdom (J.K.); and Department of Biostatistics, University of Liverpool, United Kingdom (A.P.M.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783787PMC
July 2017

Genome-wide analysis identifies 12 loci influencing human reproductive behavior.

Authors:
Nicola Barban Rick Jansen Ronald de Vlaming Ahmad Vaez Jornt J Mandemakers Felix C Tropf Xia Shen James F Wilson Daniel I Chasman Ilja M Nolte Vinicius Tragante Sander W van der Laan John R B Perry Augustine Kong Tarunveer S Ahluwalia Eva Albrecht Laura Yerges-Armstrong Gil Atzmon Kirsi Auro Kristin Ayers Andrew Bakshi Danny Ben-Avraham Klaus Berger Aviv Bergman Lars Bertram Lawrence F Bielak Gyda Bjornsdottir Marc Jan Bonder Linda Broer Minh Bui Caterina Barbieri Alana Cavadino Jorge E Chavarro Constance Turman Maria Pina Concas Heather J Cordell Gail Davies Peter Eibich Nicholas Eriksson Tõnu Esko Joel Eriksson Fahimeh Falahi Janine F Felix Mark Alan Fontana Lude Franke Ilaria Gandin Audrey J Gaskins Christian Gieger Erica P Gunderson Xiuqing Guo Caroline Hayward Chunyan He Edith Hofer Hongyan Huang Peter K Joshi Stavroula Kanoni Robert Karlsson Stefan Kiechl Annette Kifley Alexander Kluttig Peter Kraft Vasiliki Lagou Cecile Lecoeur Jari Lahti Ruifang Li-Gao Penelope A Lind Tian Liu Enes Makalic Crysovalanto Mamasoula Lindsay Matteson Hamdi Mbarek Patrick F McArdle George McMahon S Fleur W Meddens Evelin Mihailov Mike Miller Stacey A Missmer Claire Monnereau Peter J van der Most Ronny Myhre Mike A Nalls Teresa Nutile Ioanna Panagiota Kalafati Eleonora Porcu Inga Prokopenko Kumar B Rajan Janet Rich-Edwards Cornelius A Rietveld Antonietta Robino Lynda M Rose Rico Rueedi Kathleen A Ryan Yasaman Saba Daniel Schmidt Jennifer A Smith Lisette Stolk Elizabeth Streeten Anke Tönjes Gudmar Thorleifsson Sheila Ulivi Juho Wedenoja Juergen Wellmann Peter Willeit Jie Yao Loic Yengo Jing Hua Zhao Wei Zhao Daria V Zhernakova Najaf Amin Howard Andrews Beverley Balkau Nir Barzilai Sven Bergmann Ginevra Biino Hans Bisgaard Klaus Bønnelykke Dorret I Boomsma Julie E Buring Harry Campbell Stefania Cappellani Marina Ciullo Simon R Cox Francesco Cucca Daniela Toniolo George Davey-Smith Ian J Deary George Dedoussis Panos Deloukas Cornelia M van Duijn Eco J C de Geus Johan G Eriksson Denis A Evans Jessica D Faul Cinzia Felicita Sala Philippe Froguel Paolo Gasparini Giorgia Girotto Hans-Jörgen Grabe Karin Halina Greiser Patrick J F Groenen Hugoline G de Haan Johannes Haerting Tamara B Harris Andrew C Heath Kauko Heikkilä Albert Hofman Georg Homuth Elizabeth G Holliday John Hopper Elina Hyppönen Bo Jacobsson Vincent W V Jaddoe Magnus Johannesson Astanand Jugessur Mika Kähönen Eero Kajantie Sharon L R Kardia Bernard Keavney Ivana Kolcic Päivikki Koponen Peter Kovacs Florian Kronenberg Zoltan Kutalik Martina La Bianca Genevieve Lachance William G Iacono Sandra Lai Terho Lehtimäki David C Liewald Cecilia M Lindgren Yongmei Liu Robert Luben Michael Lucht Riitta Luoto Per Magnus Patrik K E Magnusson Nicholas G Martin Matt McGue Ruth McQuillan Sarah E Medland Christa Meisinger Dan Mellström Andres Metspalu Michela Traglia Lili Milani Paul Mitchell Grant W Montgomery Dennis Mook-Kanamori Renée de Mutsert Ellen A Nohr Claes Ohlsson Jørn Olsen Ken K Ong Lavinia Paternoster Alison Pattie Brenda W J H Penninx Markus Perola Patricia A Peyser Mario Pirastu Ozren Polasek Chris Power Jaakko Kaprio Leslie J Raffel Katri Räikkönen Olli Raitakari Paul M Ridker Susan M Ring Kathryn Roll Igor Rudan Daniela Ruggiero Dan Rujescu Veikko Salomaa David Schlessinger Helena Schmidt Reinhold Schmidt Nicole Schupf Johannes Smit Rossella Sorice Tim D Spector John M Starr Doris Stöckl Konstantin Strauch Michael Stumvoll Morris A Swertz Unnur Thorsteinsdottir A Roy Thurik Nicholas J Timpson Joyce Y Tung André G Uitterlinden Simona Vaccargiu Jorma Viikari Veronique Vitart Henry Völzke Peter Vollenweider Dragana Vuckovic Johannes Waage Gert G Wagner Jie Jin Wang Nicholas J Wareham David R Weir Gonneke Willemsen Johann Willeit Alan F Wright Krina T Zondervan Kari Stefansson Robert F Krueger James J Lee Daniel J Benjamin David Cesarini Philipp D Koellinger Marcel den Hoed Harold Snieder Melinda C Mills

Nat Genet 2016 12 31;48(12):1462-1472. Epub 2016 Oct 31.

Department of Sociology and Nuffield College, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695684PMC
December 2016

Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing.

Nat Genet 2016 09 1;48(9):1060-5. Epub 2016 Aug 1.

Wellcome Trust Sanger Institute, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988037PMC
September 2016

Forward and back aspiration during ST-elevation myocardial infarction: a feasibility study.

EuroIntervention 2016 Apr 8;11(14):e1639-48. Epub 2016 Apr 8.

Institute of Cardiovascular Sciences, Manchester Academic Health Sciences Centre, University of Manchester and Manchester Heart Centre, Manchester Royal Infirmary, Central Manchester University Hospitals NHS Trust, Manchester, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4244/EIJV11I14A315DOI Listing
April 2016

Impact of age on access site-related outcomes in 469,983 percutaneous coronary intervention procedures: Insights from the British Cardiovascular Intervention Society.

Catheter Cardiovasc Interv 2015 Nov 25;86(6):965-72. Epub 2015 Feb 25.

Cardiovascular Research Group, Institute of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ccd.25896DOI Listing
November 2015

Concise Review: Cardiac Disease Modeling Using Induced Pluripotent Stem Cells.

Stem Cells 2015 Sep 23;33(9):2643-51. Epub 2015 Jun 23.

Institute of Genetic Medicine, Newcastle University, The International Centre for Life, Central Parkway, Newcastle upon Tyne, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/stem.2070DOI Listing
September 2015

Increased Power for Detection of Parent-of-Origin Effects via the Use of Haplotype Estimation.

Am J Hum Genet 2015 Sep 27;97(3):419-34. Epub 2015 Aug 27.

Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajhg.2015.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564992PMC
September 2015

Genetic variants associated with risk of atrial fibrillation regulate expression of PITX2, CAV1, MYOZ1, C9orf3 and FANCC.

J Mol Cell Cardiol 2015 Aug 11;85:207-14. Epub 2015 Jun 11.

Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK; Institute of Cardiovascular Sciences, University of Manchester, Manchester, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2015.06.005DOI Listing
August 2015

Association analysis identifies new risk loci for congenital heart disease in Chinese populations.

Nat Commun 2015 Aug 18;6:8082. Epub 2015 Aug 18.

1] State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, China [2] Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms9082DOI Listing
August 2015

Stroke following percutaneous coronary intervention: type-specific incidence, outcomes and determinants seen by the British Cardiovascular Intervention Society 2007-12.

Eur Heart J 2015 Jul 20;36(25):1618-28. Epub 2015 Apr 20.

Cardiovascular Research Group, Institute of Cardiovascular Sciences, University of Manchester, Manchester, UK Farr Institute, Institute of Population Health, University of Manchester, Manchester, UK Keele Cardiac Research Group, Institutes of Science and Technology in Medicine and Primary Care, Keele University, Stoke-on-Trent, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/eurheartj/ehv113DOI Listing
July 2015

Positional mapping of PRKD1, NRP1 and PRDM1 as novel candidate disease genes in truncus arteriosus.

J Med Genet 2015 May 23;52(5):322-9. Epub 2015 Feb 23.

Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia Department of Anatomy and Cell Biology, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jmedgenet-2015-102992DOI Listing
May 2015

Using population data for assessing next-generation sequencing performance.

Bioinformatics 2015 Jan 17;31(1):56-61. Epub 2014 Sep 17.

Oxford Gene Technology, Begbroke Science Park, Oxford, Oxfordshire, OX5 1PF, Institute of Genetic Medicine, Newcastle University, International Centre for Life, Central Parkway NE1 3BZ, Newcastle upon Tyne and The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://bioinformatics.oxfordjournals.org/content/early/2014/
Web Search
http://bioinformatics.oxfordjournals.org/cgi/doi/10.1093/bio
Publisher Site
http://dx.doi.org/10.1093/bioinformatics/btu606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271148PMC
January 2015

Myocardial ischemia and reperfusion leads to transient CD8 immune deficiency and accelerated immunosenescence in CMV-seropositive patients.

Circ Res 2015 Jan 10;116(1):87-98. Epub 2014 Nov 10.

From the Institute of Genetic Medicine (J.H., E.V.S., S.E.B., S.M., B.K., I.S.), Institute of Aging and Health (C.M.-R., T.v.Z.), and Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom (A.B., M.E., R.D., S.T.), Department of Cardiology, Freeman Hospital, Newcastle upon Tyne, United Kingdom (A.B., M.E., R.D., I.S.); Flow Cytometry Core Facility, International Center for Life, Newcastle upon Tyne, United Kingdom (I.D.); Department of Immunology, Institute of Medical Microbiology and Hygiene, Freiburg University, Germany (H.P.); CLIP-Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic (K.F.); University Hospital Motol, Prague, Czech Republic (K.F.); Institute of Cardiovascular Sciences, The University of Manchester, United Kingdom (B.K.); and Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom (S.M., S.T.).

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.116.30439
Publisher Site
http://dx.doi.org/10.1161/CIRCRESAHA.116.304393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280279PMC
January 2015

Atrial fibrillation associated with ivabradine treatment: meta-analysis of randomised controlled trials.

Heart 2014 Oct 20;100(19):1506-10. Epub 2014 Jun 20.

Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK Institute of Cardiovascular Sciences, University of Manchester, Manchester, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/heartjnl-2014-305482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174120PMC
October 2014

Renal denervation and blood pressure reduction in resistant hypertension: a systematic review and meta-analysis.

Open Heart 2014 5;1(1):e000092. Epub 2014 Aug 5.

Cardiovascular Institute, University of Manchester , Manchester , UK ; Leeds General Infirmary, Great George Street, Leeds , UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/openhrt-2014-000092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189337PMC
October 2014

Research capacity. Enabling the genomic revolution in Africa.

Authors:
Charles Rotimi Akin Abayomi Alash'le Abimiku Victoria May Adabayeri Clement Adebamowo Ezekiel Adebiyi Adebowale D Ademola Adebowale Adeyemo Dwomoa Adu Dissou Affolabi Godfred Agongo Samuel Ajayi Sally Akarolo-Anthony Rufus Akinyemi Albert Akpalu Marianne Alberts Orlando Alonso Betancourt Ahmed Mansour Alzohairy Gobena Ameni Olukemi Amodu Gabriel Anabwani Kristian Andersen Fatiu Arogundade Oyedunni Arulogun Danny Asogun Rasheed Bakare Naby Balde Mary Lynn Baniecki Christine Beiswanger Alia Benkahla Lara Bethke Micheal Boehnke Vincent Boima James Brandful Andrew I Brooks Frank C Brosius Chester Brown Bruno Bucheton David T Burke Barrington G Burnett Stacy Carrington-Lawrence Nadia Carstens John Chisi Alan Christoffels Richard Cooper Heather Cordell Nigel Crowther Talishiea Croxton Jantina de Vries Leslie Derr Peter Donkor Seydou Doumbia Audrey Duncanson Ivy Ekem Ahmed El Sayed Mark E Engel John C K Enyaru Dean Everett Faisal M Fadlelmola Eyitayo Fakunle Kenneth H Fischbeck Anne Fischer Onikepe Folarin Junaid Gamieldien Robert F Garry Simani Gaseitsiwe Rasheed Gbadegesin Anita Ghansah Maria Giovanni Parham Goesbeck F Xavier Gomez-Olive Donald S Grant Ravnit Grewal Mark Guyer Neil A Hanchard Christian T Happi Scott Hazelhurst Branwen J Hennig Christiane Hertz- Fowler Winston Hide Friedhelm Hilderbrandt Christopher Hugo-Hamman Muntaser E Ibrahim Regina James Yasmina Jaufeerally-Fakim Carolyn Jenkins Ute Jentsch Pan-Pan Jiang Moses Joloba Victor Jongeneel Fourie Joubert Mukthar Kader Kathleen Kahn Pontiano Kaleebu Saidi H Kapiga Samar Kamal Kassim Ishmael Kasvosve Jonathan Kayondo Bernard Keavney Adeodata Kekitiinwa Sheik Humarr Khan Paul Kimmel Mary-Claire King Robert Kleta Mathurin Koffi Jeffrey Kopp Matthias Kretzler Judit Kumuthini Samuel Kyobe Catherine Kyobutungi Daniel T Lackland Karen A Lacourciere Guida Landouré Rita Lawlor Thomas Lehner Maia Lesosky Naomi Levitt Katherine Littler Zane Lombard Jeanne F Loring Sylvester Lyantagaye Annette Macleod Ebony B Madden Chengetai R Mahomva Julie Makani Manmak Mamven Marape Marape Graeme Mardon Patricia Marshall Darren P Martin Daniel Masiga Robin Mason Michael Mate-Kole Enock Matovu Mary Mayige Bongani M Mayosi Jean Claude Mbanya Sheryl A McCurdy Mark I McCarthy Helen McIlleron S O Mc'Ligeyo Corrine Merle Ana Olga Mocumbi Charles Mondo John V Moran Ayesha Motala Marva Moxey-Mims Wata Sununguko Mpoloka Chisomo L Msefula Thuli Mthiyane Nicola Mulder Gebregziab her Mulugeta Dieuodonne Mumba John Musuku Mo Nagdee Oyekanmi Nash Daouda Ndiaye Anh Quynh Nguyen Mark Nicol Oathokwa Nkomazana Shane Norris Betty Nsangi Alexander Nyarko Moffat Nyirenda Eileen Obe Reginald Obiakor Abraham Oduro Solomon F Ofori-Acquah Okechukwu Ogah Stephen Ogendo Kwaku Ohene-Frempong Akinlolu Ojo Timothy Olanrewaju John Oli Charlotte Osafo Odile Ouwe Missi Oukem-Boyer Bruce Ovbiagele Andrew Owen Mayowa Ojo Owolabi Lukman Owolabi Ellis Owusu-Dabo Guillaume Pare Rulan Parekh Hugh G Patterton Margaret B Penno Jane Peterson Rembert Pieper Jacob Plange-Rhule Martin Pollak Julia Puzak Rajkumar S Ramesar Michele Ramsay Rebekah Rasooly Shiksha Reddy Pardis C Sabeti Kwamena Sagoe Tunde Salako Oumar Samassékou Manjinder S Sandhu Osman Sankoh Fred Stephen Sarfo Marie Sarr Gasnat Shaboodien Issa Sidibe Gustave Simo Martin Simuunza Liam Smeeth Eugene Sobngwi Himla Soodyall Hermann Sorgho Oumou Sow Bah Sudha Srinivasan Dan J Stein Ezra S Susser Carmen Swanepoel Godfred Tangwa Andrew Tareila Ozlem Tastan Bishop Bamidele Tayo Nicki Tiffin Halidou Tinto Ekaete Tobin Stephen Meir Tollman Mahamadou Traoré Marsha J Treadwell Jennifer Troyer Masego Tsimako-Johnstone Vincent Tukei Ifeoma Ulasi Nzovu Ulenga Beverley van Rooyen Ablo Prudence Wachinou Salina P Waddy Alisha Wade Misaki Wayengera James Whitworth Louise Wideroff Cheryl A Winkler Sarah Winnicki Ambroise Wonkam Mengistu Yewondwos Tadase sen Nathan Yozwiak Heather Zar

Science 2014 Jun;344(6190):1346-8

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1251546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138491PMC
June 2014

An induced pluripotent stem cell model of hypoplastic left heart syndrome (HLHS) reveals multiple expression and functional differences in HLHS-derived cardiac myocytes.

Stem Cells Transl Med 2014 Apr 3;3(4):416-23. Epub 2014 Mar 3.

Institute of Genetic Medicine and Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom; Soochow University, Su Zhou, China; Princess Al Jawhara Center of Excellence in Research, King Abdulaziz University, Jeddah, Saudi Arabia; Centre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, Brno, Czech Republic; Institute of Cardiovascular Science, Manchester Academic Health Science Centre, CoreTechnology Facility, Manchester, United Kingdom; School of Biomedical Sciences, University of Durham, Durham, United Kingdom; Department of Human Genetics, University of Kragujevac, Kragujevac, Serbia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5966/sctm.2013-0105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973710PMC
April 2014

Bariatric surgery and its impact on cardiovascular disease and mortality: a systematic review and meta-analysis.

Int J Cardiol 2014 Apr 24;173(1):20-8. Epub 2014 Feb 24.

Norwich Medical School, University of East Anglia, Norwich, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijcard.2014.02.026DOI Listing
April 2014

Mutations in FAM111B cause hereditary fibrosing poikiloderma with tendon contracture, myopathy, and pulmonary fibrosis.

Am J Hum Genet 2013 Dec 21;93(6):1100-7. Epub 2013 Nov 21.

Unité de Génétique Clinique, Service de Génétique Médicale, Centre de Référence Anomalies de Développement et Syndromes Malformatifs de l'Interrégion Grand-Ouest, Centre Hospitalier Universitaire Nantes, 9 Quai Moncousu, 44093 Nantes Cedex 1, France; Institut National de la Santé et de la Recherche Médicale UMR 1089, Atlantic Gene Therapy Institute, University of Nantes, 44007 Nantes, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajhg.2013.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853004PMC
December 2013

Defining cardiac adaptations and safety of endurance training in patients with m.3243A>G-related mitochondrial disease.

Int J Cardiol 2013 Oct 3;168(4):3599-608. Epub 2013 Jun 3.

Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE7 7DN, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijcard.2013.05.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819621PMC
October 2013

Ebstein anomaly associated with left ventricular noncompaction: an autosomal dominant condition that can be caused by mutations in MYH7.

Am J Med Genet C Semin Med Genet 2013 Aug 21;163C(3):178-84. Epub 2013 Jun 21.

Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajmg.c.31365DOI Listing
August 2013

Provision of gastroprotective medication and bleeding risk following acute coronary syndrome.

J Invasive Cardiol 2013 Aug;25(8):397-401

Department of Cardiology, Freeman Hospital, Newcastle-upon-Tyne, United Kingdom.

View Article

Download full-text PDF

Source
August 2013

Functional significance of SRJ domain mutations in CITED2.

PLoS One 2012 17;7(10):e46256. Epub 2012 Oct 17.

Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046256PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474824PMC
April 2013

Prevalence of left ventricular dysfunction in a UK community sample of very old people: the Newcastle 85+ study.

Heart 2012 Oct 2;98(19):1418-23. Epub 2012 Aug 2.

Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/heartjnl-2012-302457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437786PMC
October 2012

Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism.

J Am Coll Cardiol 2012 Aug;60(8):722-9

Population Genomics, deCODE Genetics, Reykjavik, Iceland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jacc.2012.01.078DOI Listing
August 2012

Left ventricular torsion, energetics, and diastolic function in normal human aging.

Am J Physiol Heart Circ Physiol 2012 Feb 16;302(4):H885-92. Epub 2011 Dec 16.

Newcastle Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpheart.00985.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322734PMC
February 2012

Genetic mechanisms mediating atherosclerosis susceptibility at the chromosome 9p21 locus.

Curr Atheroscler Rep 2011 Jun;13(3):193-201

Institute of Human Genetics, Newcastle University, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11883-011-0178-zDOI Listing
June 2011

Common variation at the 11-β hydroxysteroid dehydrogenase type 1 gene is associated with left ventricular mass.

Circ Cardiovasc Genet 2011 Apr 14;4(2):156-62. Epub 2011 Mar 14.

Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGENETICS.110.958496DOI Listing
April 2011

Mutations in the sarcomere gene MYH7 in Ebstein anomaly.

Circ Cardiovasc Genet 2011 Feb 2;4(1):43-50. Epub 2010 Dec 2.

Heart Failure Research Center, the Department of Anatomy, Embryology and Physiology, Academic Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGENETICS.110.957985DOI Listing
February 2011

C reactive protein and the risk of cardiovascular disease.

Authors:
Bernard Keavney

BMJ 2011 Feb 15;342:d144. Epub 2011 Feb 15.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmj.d144DOI Listing
February 2011

Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression.

PLoS Genet 2010 Apr 8;6(4):e1000899. Epub 2010 Apr 8.

Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom.

View Article

Download full-text PDF

Source
https://dx.plos.org/10.1371/journal.pgen.1000899
Publisher Site
http://dx.doi.org/10.1371/journal.pgen.1000899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851566PMC
April 2010

The interleukin-1 cluster, dyslipidaemia and risk of myocardial infarction.

Authors:
Bernard Keavney

BMC Med 2010 Jan 13;8. Epub 2010 Jan 13.

BHF Professor of Cardiology, Institute of Human Genetics, Newcastle University, Newcastle, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1741-7015-8-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822811PMC
January 2010

STK39 polymorphisms and blood pressure: an association study in British Caucasians and assessment of cis-acting influences on gene expression.

BMC Med Genet 2009 Dec 14;10:135. Epub 2009 Dec 14.

Institute of Human Genetics, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2350-10-135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803166PMC
December 2009

Familial and phenotypic associations of the aldosterone Renin ratio.

J Clin Endocrinol Metab 2009 Nov 9;94(11):4324-33. Epub 2009 Oct 9.

Faculty of Medicine, University of Glasgow, British Heart Foundation Glasgow Cardiovascular Research Centre, Glasgow G12 8TA, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2009-1406DOI Listing
November 2009

Ambulatory blood pressure is associated with polymorphic variation in P2X receptor genes.

Hypertension 2008 Nov 13;52(5):980-5. Epub 2008 Oct 13.

Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.108.113282DOI Listing
November 2008

More evidence against a causal association between C-reactive protein and diabetes.

Authors:
Bernard Keavney

PLoS Med 2008 Aug;5(8):e174

Department of Cardiology and Institute of Human Genetics, University of Newcastle, Newcastle, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pmed.0050174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504485PMC
August 2008

Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk.

JAMA 2008 Jun;299(23):2777-88

Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, England CB1 8RN.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jama.299.23.2777DOI Listing
June 2008

Plasma potassium level is associated with common genetic variation in the beta-subunit of the epithelial sodium channel.

Am J Physiol Regul Integr Comp Physiol 2008 Mar 9;294(3):R1068-72. Epub 2008 Jan 9.

Institute of Human Genetics, New Castle University, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpregu.00732.2007DOI Listing
March 2008

Genome-wide linkage analysis of electrocardiographic and echocardiographic left ventricular hypertrophy in families with hypertension.

Eur Heart J 2008 Feb;29(4):525-30

Department of Medicine, University of Cape Town, J Floor Old Main Building, Groote Schuur Hospital, Anzio Road Observatory, Cape Town 7925, W Cape, South Africa.

View Article

Download full-text PDF

Source
https://academic.oup.com/eurheartj/article-lookup/doi/10.109
Publisher Site
http://dx.doi.org/10.1093/eurheartj/ehn028DOI Listing
February 2008