Bernard Faller

Correction to "Prediction of Fraction Unbound in Microsomal and Hepatocyte Incubations: A Comparison of Methods across Industry Datasets".

Authors:

Susanne Winiwarter George Chang Prashant Desai Karsten Menzel Bernard Faller Rieko Arimoto Christopher Keefer Fabio Broccatelli

Mol Pharm 2019 Nov 9;16(11):4755. Epub 2019 Oct 9.

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November 2019

Prediction of Fraction Unbound in Microsomal and Hepatocyte Incubations: A Comparison of Methods across Industry Datasets.

Authors:

Susanne Winiwarter George Chang Prashant Desai Karsten Menzel Bernard Faller Rieko Arimoto Christopher Keefer Fabio Broccatell

Mol Pharm 2019 09 8;16(9):4077-4085. Epub 2019 Aug 8.

Genentech Inc. , South San Francisco , California 94080 , United States.

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September 2019

Drug permeability profiling using cell-free permeation tools: Overview and applications.

Authors:

Philippe Berben Annette Bauer-Brandl Martin Brandl Bernard Faller Gøril Eide Flaten Ann-Christin Jacobsen Joachim Brouwers Patrick Augustijns

Eur J Pharm Sci 2018 Jul 13;119:219-233. Epub 2018 Apr 13.

Drug Delivery and Disposition, KU Leuven, Gasthuisberg O&N II, Herestraat 49, Box 921, 3000 Leuven, Belgium. Electronic address:

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July 2018

Benefit of Retraining pKa Models Studied Using Internally Measured Data.

Authors:

Peter Gedeck Yipin Lu Suzanne Skolnik Stephane Rodde Gavin Dollinger Weiping Jia Giuliano Berellini Riccardo Vianello Bernard Faller Franco Lombardo

J Chem Inf Model 2015 Jul 29;55(7):1449-59. Epub 2015 Jun 29.

§Novartis Institute for Biomedical Research, 250 Massachusetts Ave, Cambridge, Massachusetts 02139, United States.

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July 2015

Passive lipoidal diffusion and carrier-mediated cell uptake are both important mechanisms of membrane permeation in drug disposition.

Authors:

Dennis Smith Per Artursson Alex Avdeef Li Di Gerhard F Ecker Bernard Faller J Brian Houston Manfred Kansy Edward H Kerns Stefanie D Krämer Hans Lennernäs Han van de Waterbeemd Kiyohiko Sugano Bernard Testa

Mol Pharm 2014 Jun 6;11(6):1727-38. Epub 2014 May 6.

4 The Maltings, Walmer, Kent, CT14 7AR, U.K.

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June 2014

Evidence-based approach to assess passive diffusion and carrier-mediated drug transport.

Authors:

Li Di Per Artursson Alex Avdeef Gerhard F Ecker Bernard Faller Holger Fischer J Brian Houston Manfred Kansy Edward H Kerns Stefanie D Krämer Hans Lennernäs Kiyohiko Sugano

Drug Discov Today 2012 Aug 4;17(15-16):905-12. Epub 2012 Apr 4.

Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, CT 06340, USA.

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August 2012

Structure-activity relationship and pharmacokinetic studies of sotrastaurin (AEB071), a promising novel medicine for prevention of graft rejection and treatment of psoriasis.

Authors:

Jürgen Wagner Peter von Matt Bernard Faller Nigel G Cooke Rainer Albert Richard Sedrani Hansjörg Wiegand Christian Jean Christian Beerli Gisbert Weckbecker Jean-Pierre Evenou Gerhard Zenke Sylvain Cottens

J Med Chem 2011 Sep 8;54(17):6028-39. Epub 2011 Aug 8.

Novartis Institutes for BioMedical Research, Basel CH-4002, Switzerland.

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September 2011

Evolution of the physicochemical properties of marketed drugs: can history foretell the future?

Authors:

Bernard Faller Giorgio Ottaviani Peter Ertl Giuliano Berellini Alan Collis

Drug Discov Today 2011 Nov 18;16(21-22):976-84. Epub 2011 Jul 18.

Novartis Institutes for BioMedical Research, Basel, Switzerland.

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November 2011

CYP3A time-dependent inhibition risk assessment validated with 400 reference drugs.

Authors:

Alfred Zimmerlin Markus Trunzer Bernard Faller

Drug Metab Dispos 2011 Jun 7;39(6):1039-46. Epub 2011 Mar 7.

Discovery ADME, Novartis Institutes for BioMedical Research, WSJ-350.3.12, P.O. Box, CH-4002 Basel, Switzerland.

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June 2011

Coexistence of passive and carrier-mediated processes in drug transport.

Authors:

Kiyohiko Sugano Manfred Kansy Per Artursson Alex Avdeef Stefanie Bendels Li Di Gerhard F Ecker Bernard Faller Holger Fischer Grégori Gerebtzoff Hans Lennernaes Frank Senner

Nat Rev Drug Discov 2010 Aug;9(8):597-614

Pfizer, Research Formulation, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK.

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August 2010

What is modulating solubility in simulated intestinal fluids?

Authors:

Giorgio Ottaviani Daniel J Gosling Celine Patissier Stephane Rodde Liping Zhou Bernard Faller

Eur J Pharm Sci 2010 Nov 23;41(3-4):452-7. Epub 2010 Jul 23.

Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, Basel, Switzerland.

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November 2010

The identification of indacaterol as an ultralong-acting inhaled beta2-adrenoceptor agonist.

J Med Chem 2010 May;53(9):3675-84

Respiratory Diseases Area, Novartis Institutes for Biomedical Research, Wimblehurst Road, Horsham, West Sussex RH12 5AB, UK.

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May 2010

Metabolic soft spot identification and compound optimization in early discovery phases using MetaSite and LC-MS/MS validation.

Authors:

Markus Trunzer Bernard Faller Alfred Zimmerlin

J Med Chem 2009 Jan;52(2):329-35

Novartis Institutes for BioMedical Research, Metabolism and Pharmacokinetics, Postfach, CH-4002, Basel, Switzerland.

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January 2009

Artificial membrane assays to assess permeability.

Authors:

Bernard Faller

Curr Drug Metab 2008 Nov;9(9):886-92

Novartis Institutes for BioMedical Research, Basel, Switzerland.

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November 2008

New approach to measure protein binding based on a parallel artificial membrane assay and human serum albumin.

Authors:

Elisabet Lázaro Philip J Lowe Xavier Briand Bernard Faller

J Med Chem 2008 Apr 19;51(7):2009-17. Epub 2008 Mar 19.

Departament de Química Analítica, Universitat de Barcelona, Martí i Franquès 1, Barcelona, Spain.

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April 2008

PAMPA--critical factors for better predictions of absorption.

Authors:

Alex Avdeef Stefanie Bendels Li Di Bernard Faller Manfred Kansy Kiyohiko Sugano Yukinori Yamauchi

J Pharm Sci 2007 Nov;96(11):2893-909

pION INC, 5 Constitution Way, Woburn, Massachusetts 01801, USA.

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November 2007

Computational approaches to determine drug solubility.

Authors:

Bernard Faller Peter Ertl

Adv Drug Deliv Rev 2007 Jul 26;59(7):533-45. Epub 2007 May 26.

Novartis Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Basel, Switzerland.

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July 2007

Modeling promiscuity based on in vitro safety pharmacology profiling data.

Authors:

Kamal Azzaoui Jacques Hamon Bernard Faller Steven Whitebread Edgar Jacoby Andreas Bender Jeremy L Jenkins Laszlo Urban

ChemMedChem 2007 Jun;2(6):874-80

CPC/LFP/MLI, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Postfach, 4002 Basel, Switzerland.

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June 2007

High-throughput in vitro profiling assays: lessons learnt from experiences at Novartis.

Authors:

Bernard Faller Jianling Wang Alfred Zimmerlin Leslie Bell Jacques Hamon Steven Whitebread Kamal Azzaoui Dejan Bojanic Laszlo Urban

Expert Opin Drug Metab Toxicol 2006 Dec;2(6):823-33

Novartis Institutes for BioMedical Research, Basel, Switzerland.

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December 2006

Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects.

Authors:

Stefan Raduner Adriana Majewska Jian-Zhong Chen Xiang-Qun Xie Jacques Hamon Bernard Faller Karl-Heinz Altmann Jürg Gertsch

J Biol Chem 2006 May 17;281(20):14192-206. Epub 2006 Mar 17.

Department of Chemistry and Applied Biosciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, CH-8093 Zürich, Switzerland.

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May 2006

Publications by authors named "Bernard Faller"

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