Publications by authors named "Bernagout Solène"

4 Publications

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Non-Essential Trace Elements Dietary Exposure in French Polynesia: Intake Assessment, Nail Bio Monitoring and Thyroid Cancer Risk

Asian Pac J Cancer Prev 2019 Feb 26;20(2):355-367. Epub 2019 Feb 26.

Radiation Epidemiology Group, Centre for Research in Epidemiology and Population Health (CESP), UMR 1018 Inserm, Villejuif, France.

Background: In French Polynesia, thyroid cancer mortality and incidence is reported to be the highest in the world. Excessive levels of non-essential trace elements (nETE) in the body are associated with several types of cancer. Objective: The present study aims to provide quantitative information on food contamination by mercury (Hg), lead (Pb), arsenic (As) and cadmium (Cd) in French Polynesia and its potential correlation with measurements performed in fingernails of Polynesians, and then to investigate the potential association between these nETE and different thyroid cancer risks. Methods: The study population included 229 interviewed cases and 373 interviewed controls We performed a descriptive analysis of Polynesian food and examined the association between thyroid cancer risk and daily intake levels of nETE and with fingernail nETE levels. Results: Hg contamination was mainly present in sea products, Pb contamination was present in almost all samples, Cd was detectable in starchy food and As was detectable in all sea products. No patient exceeded dietary contamination WHO limits for Pb, 2 participants exceeded it for Hg and 3 individuals (0.5%) for cadmium. In fingernail clippings, the most detectable pollutant was Pb (553 participants), then Hg (543 participants) then Cd (only in 130 participants). Thyroid cancer risk was increased more than 4 times by Pb daily intake in patients with a history of cancer in first-degree relatives than in ones without (p for interaction =0.01), and 2 times more in women with more than 3 pregnancies than in those with none or less (p for interaction =0.005); it was also increased following As intake by more than 30% in patients with a history of cancer in first-degree relatives than in ones without (p for interaction =0.05). Conclusion: Locally produced foods are not a source of nETE exposure in French Polynesia. Dieatry nETE exposure and fingernail nETE concentration are not associated to differentiated thyroid cancer risk. No correlation found between nETE dietary exposure and fingernail nETE concentration.
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http://dx.doi.org/10.31557/APJCP.2019.20.2.355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897028PMC
February 2019

Response of the pearl oyster Pinctada margaritifera to cadmium and chromium: Identification of molecular biomarkers.

Mar Pollut Bull 2017 May 18;118(1-2):420-426. Epub 2017 Mar 18.

Ifremer, UMR 241 EIO, UPF-ILM-IRD, Labex Corail, BP 49, 98719 Taravao, Tahiti, French Polynesia. Electronic address:

This study was designed to identify in the pearl oyster Pinctada margaritifera, used as a bio-accumulator, molecular biomarkers for the presence of heavy metals in the lagoon environment. Pearl oysters were exposed to 2 concentrations (1 and 10μgL) of cadmium (Cd) and chromium (Cr) compared to a control. Twelve target genes encoding proteins potentially involved in the response to heavy metal contamination with antioxidant, detoxification or apoptosis activities were selected. P. margaritifera accumulated Cd but not Cr, and mortality was related to the amount of Cd accumulated in tissues. In response to Cd-Cr contamination, metallothionein (MT) was significantly up-regulated by Cd-Cr at both concentrations, while 7 others (SOD, CAT, GPX, GSTO, GSTM, CASP, MDR) were down-regulated. Based on the development of these molecular tools, we propose that the pearl oyster, P. margaritifera, could be used as a sentinel species for heavy metal contamination in the lagoons of tropical ecosystems.
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http://dx.doi.org/10.1016/j.marpolbul.2017.03.012DOI Listing
May 2017

Determination of total iodine in French Polynesian foods: method validation and occurrence data.

Food Chem 2015 Feb 7;169:134-40. Epub 2014 Aug 7.

University of Paris-Est, Anses, Maisons-Alfort Laboratory for Food Safety, Department of Chemical Contaminants in Food, Metallic Trace Elements and Minerals Unit, Maisons-Alfort, France. Electronic address:

Pacific Island populations show some of the highest incidences of thyroid cancer in the world, and iodine deficiency is suspected to play a role. Iodine content was determined in 124 different French Polynesian food samples using inductively coupled plasma-mass spectrometry after alkaline digestion. For samples containing starch, the method was optimised by including an additional enzymatic treatment step. This analytical method was validated with an accuracy profile approach, using certified reference materials with iodine contents ranging from 0.027 to 4.95mgiodinekg(-1) dry weight. The trueness bias ranged from -5.8% to 22.4% and the highest observed intermediate precision coefficient of variation CVR was 11% in starchy materials. Tested Polynesian foods showed large variation in iodine content, with values of 0.014-0.032mgkg(-1) for fruits, 0.014-0.081mgkg(-1) for starchy samples, 0.027-1.85mgkg(-1) for green vegetables, 0.222-5.19mgkg(-1) for fish, 6.51-85.6mgkg(-1) for shellfish, and 0.004-1.39mgkg(-1) for beverages.
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http://dx.doi.org/10.1016/j.foodchem.2014.07.142DOI Listing
February 2015

Speciation of dissolved copper within an active hydrothermal edifice on the Lucky Strike vent field (MAR, 37 degrees N).

Sci Total Environ 2009 Jan 11;407(2):869-78. Epub 2008 Nov 11.

Ifremer centre de Brest, Département Etudes des Ecosystèmes Profonds, BP70, F-29280 Plouzané, France.

The objective of this study was to determine the concentrations of different fractions of dissolved copper (after filtration at 0.45 microm) along the cold part of the hydrothermal fluid-seawater mixing zone on the Tour Eiffel edifice (MAR). Dissolved copper was analyzed by stripping chronopotentiometry (SCP) after chromatographic C(18) extraction. Levels of total dissolved copper (0.03 to 5.15 microM) are much higher than those reported for deep-sea oceanic waters but in accordance with data previously obtained in this area. Speciation measurements show that the hydrophobic organic fraction (C(18)Cu) is very low (2+/-1%). Dissolved copper is present mainly as inorganic and hydrophilic organic complexes (nonC(18)Cu). The distribution of copper along the pH gradient shows the same pattern for each fraction. Copper concentrations increase from pH 5.6 to 6.5 and then remain relatively constant at pH>6.5. Concentrations of oxygen and total sulphides demonstrate that the copper anomaly corresponds to the transition between suboxic and oxic waters. The increase of dissolved copper should correspond to the oxidative redissolution of copper sulphide particles formed in the vicinity of the fluid exit. The presence of such a secondary dissolved copper source, associated with the accumulation of metal sulphide particles, could play a significant role in the distribution of fauna in the different habitats available at vents.
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http://dx.doi.org/10.1016/j.scitotenv.2008.09.056DOI Listing
January 2009