Bernadette Breiden

Mechanism of Secondary Ganglioside and Lipid Accumulation in Lysosomal Disease.

Authors:

Bernadette Breiden Konrad Sandhoff

Int J Mol Sci 2020 Apr 7;21(7). Epub 2020 Apr 7.

Membrane Biology and Lipid Biochemistry Unit, LIMES Institute, University of Bonn, 53121 Bonn, Germany.

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April 2020

Emerging mechanisms of drug-induced phospholipidosis.

Authors:

Bernadette Breiden Konrad Sandhoff

Biol Chem 2019 12;401(1):31-46

LIMES Institut, Membrane Biology and Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany.

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December 2019

Lysosomal Glycosphingolipid Storage Diseases.

Authors:

Bernadette Breiden Konrad Sandhoff

Annu Rev Biochem 2019 06;88:461-485

LIMES Institute, Membrane Biology and Lipid Biochemistry Unit, Universität Bonn, D-53121 Bonn, Germany; email: ,

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June 2019

Ganglioside GM2 catabolism is inhibited by storage compounds of mucopolysaccharidoses and by cationic amphiphilic drugs.

Authors:

Susi Anheuser Bernadette Breiden Konrad Sandhoff

Mol Genet Metab 2019 Sep - Oct;128(1-2):75-83. Epub 2019 May 4.

LIMES Institute, Membrane Biology & Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany. Electronic address:

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April 2020

Membrane lipids and their degradation compounds control GM2 catabolism at intralysosomal luminal vesicles.

Authors:

Susi Anheuser Bernadette Breiden Konrad Sandhoff

J Lipid Res 2019 06 15;60(6):1099-1111. Epub 2019 Apr 15.

Membrane Biology and Lipid Biochemistry Unit, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.

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June 2019

Ganglioside Metabolism and Its Inherited Diseases.

Authors:

Bernadette Breiden Konrad Sandhoff

Methods Mol Biol 2018 ;1804:97-141

LIMES Institute, Membrane Biology & Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Bonn, Germany.

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March 2019

Inactivation of ceramide synthase 2 catalytic activity in mice affects transcription of genes involved in lipid metabolism and cell division.

Authors:

Andreas Bickert Paul Kern Martina van Uelft Stefanie Herresthal Thomas Ulas Katharina Gutbrod Bernadette Breiden Joachim Degen Konrad Sandhoff Joachim L Schultze Peter Dörmann Dieter Hartmann Reinhard Bauer Klaus Willecke

Biochim Biophys Acta Mol Cell Biol Lipids 2018 07 10;1863(7):734-749. Epub 2018 Apr 10.

Molecular Genetics, Life and Medical Sciences Institute, University of Bonn, Germany. Electronic address:

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July 2018

Ceramide Synthase Schlank Is a Transcriptional Regulator Adapting Gene Expression to Energy Requirements.

Authors:

Mariangela Sociale Anna-Lena Wulf Bernadette Breiden Kathrin Klee Melanie Thielisch Franka Eckardt Julia Sellin Margret H Bülow Sinah Löbbert Nadine Weinstock André Voelzmann Joachim Schultze Konrad Sandhoff Reinhard Bauer

Cell Rep 2018 01 28;22(4):967-978. Epub 2018 Jan 28.

LIMES-Institute, Unit Development, Genetics and Molecular Physiology, Department for Molecular Developmental Biology, University of Bonn, Carl-Troll-Strasse 31, 53115 Bonn, Germany. Electronic address:

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January 2018

Synthetic Glycoforms Reveal Carbohydrate-Dependent Bioactivity of Human Saposin D.

Authors:

Christopher G F Graf Christian Schulz Marina Schmälzlein Christian Heinlein Manuel Mönnich Lukas Perkams Markus Püttner Irene Boos Markus Hessefort Jose Nelson Lombana Sanchez Michael Weyand Clemens Steegborn Bernadette Breiden Kerstin Ross Günter Schwarzmann Konrad Sandhoff Carlo Unverzagt

Angew Chem Int Ed Engl 2017 05 5;56(19):5252-5257. Epub 2017 Apr 5.

Bioorg. Chemie, Gebäude NWI, Universität Bayreuth, 95440, Bayreuth, Germany.

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May 2017

Identification of a feedback loop involving β-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease.

Authors:

Sophie Schonauer Heinz G Körschen Anke Penno Andreas Rennhack Bernadette Breiden Konrad Sandhoff Katharina Gutbrod Peter Dörmann Diana N Raju Per Haberkant Mathias J Gerl Britta Brügger Hila Zigdon Ayelet Vardi Anthony H Futerman Christoph Thiele Dagmar Wachten

J Biol Chem 2017 04 3;292(15):6177-6189. Epub 2017 Mar 3.

From the Minerva Max Planck Research Group, Molecular Physiology, and

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April 2017

Lipids regulate the hydrolysis of membrane bound glucosylceramide by lysosomal β-glucocerebrosidase.

Authors:

Misbaudeen Abdul-Hammed Bernadette Breiden Günter Schwarzmann Konrad Sandhoff

J Lipid Res 2017 03 26;58(3):563-577. Epub 2017 Jan 26.

Life and Medical Sciences (LIMES) Institut, Membrane Biology and Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Bonn, Germany

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March 2017

Membrane-spanning lipids for an uncompromised monitoring of membrane fusion and intermembrane lipid transfer.

Authors:

Günter Schwarzmann Bernadette Breiden Konrad Sandhoff

J Lipid Res 2015 Oct 11;56(10):1861-79. Epub 2015 Aug 11.

Life & Medical Sciences (LIMES) Institute, Membrane Biology & Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, D-53121 Bonn, Germany.

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October 2015

Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity.

Authors:

Susi Anheuser Bernadette Breiden Günter Schwarzmann Konrad Sandhoff

J Lipid Res 2015 Sep 14;56(9):1747-61. Epub 2015 Jul 14.

LIMES Institute, Membrane Biology and Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, D-53121 Bonn, Germany.

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September 2015

Accumulation of glucosylceramide in the absence of the beta-glucosidase GBA2 alters cytoskeletal dynamics.

Authors:

Diana Raju Sophie Schonauer Hussein Hamzeh Kevin C Flynn Frank Bradke Katharina Vom Dorp Peter Dörmann Yildiz Yildiz Christian Trötschel Ansgar Poetsch Bernadette Breiden Konrad Sandhoff Heinz G Körschen Dagmar Wachten

PLoS Genet 2015 Mar 24;11(3):e1005063. Epub 2015 Mar 24.

Minerva Research Group-Molecular Physiology, Center of Advanced European Studies and Research, Bonn, Germany.

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March 2015

Acid sphingomyelinase activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2.

Authors:

Vincent O Oninla Bernadette Breiden Jonathan O Babalola Konrad Sandhoff

J Lipid Res 2014 Dec 22;55(12):2606-19. Epub 2014 Oct 22.

LIMES Institute, Membrane Biology and Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, D-53121 Bonn, Germany.

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December 2014

Functional and genetic characterization of the non-lysosomal glucosylceramidase 2 as a modifier for Gaucher disease.

Authors:

Yildiz Yildiz Per Hoffmann Stefan Vom Dahl Bernadette Breiden Roger Sandhoff Claus Niederau Mia Horwitz Stefan Karlsson Mirella Filocamo Deborah Elstein Michael Beck Konrad Sandhoff Eugen Mengel Maria C Gonzalez Markus M Nöthen Ellen Sidransky Ari Zimran Manuel Mattheisen

Orphanet J Rare Dis 2013 Sep 26;8:151. Epub 2013 Sep 26.

Department of Internal Medicine I, University Clinic of Bonn, Bonn, Germany.

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September 2013

The role of sphingolipid metabolism in cutaneous permeability barrier formation.

Authors:

Bernadette Breiden Konrad Sandhoff

Biochim Biophys Acta 2014 Mar 15;1841(3):441-52. Epub 2013 Aug 15.

LIMES, Membrane Biology & Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany. Electronic address:

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March 2014

TCF/Lef1-mediated control of lipid metabolism regulates skin barrier function.

Authors:

Dagmar Fehrenschild Uwe Galli Bernadette Breiden Wilhelm Bloch Peter Schettina Susanne Brodesser Christian Michels Christian Günschmann Konrad Sandhoff Carien M Niessen Catherin Niemann

J Invest Dermatol 2012 Feb 22;132(2):337-45. Epub 2011 Sep 22.

Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.

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February 2012

Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation.

Authors:

Irfan Y Tamboli Heike Hampel Nguyen T Tien Karen Tolksdorf Bernadette Breiden Paul M Mathews Paul Saftig Konrad Sandhoff Jochen Walter

J Neurosci 2011 Feb;31(5):1837-49

Department of Neurology, University of Bonn, 53127 Bonn, Germany.

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February 2011

PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin.

Authors:

Simona Frateschi Eric Camerer Giovanna Crisante Sarah Rieser Mathieu Membrez Roch-Philippe Charles Friedrich Beermann Jean-Christophe Stehle Bernadette Breiden Konrad Sandhoff Samuel Rotman Marek Haftek Anne Wilson Stephan Ryser Martin Steinhoff Shaun R Coughlin Edith Hummler

Nat Commun 2011 Jan;2:161

Department of Pharmacology and Toxicology, University of Lausanne, Lausanne 1005, Switzerland.

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January 2011

Regulation of the NPC2 protein-mediated cholesterol trafficking by membrane lipids.

Authors:

Hichem D Gallala Bernadette Breiden Konrad Sandhoff

J Neurochem 2011 Mar 7;116(5):702-7. Epub 2011 Jan 7.

LIMES, Membrane Biology & Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Bonn, Germany.

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March 2011

Role of endosomal membrane lipids and NPC2 in cholesterol transfer and membrane fusion.

Authors:

Misbaudeen Abdul-Hammed Bernadette Breiden Matthew A Adebayo Jonathan O Babalola Günter Schwarzmann Konrad Sandhoff

J Lipid Res 2010 Jul 23;51(7):1747-60. Epub 2010 Feb 23.

Membrane Biology and Biochemistry Unit, Life and Medical Sciences Institute (LIMES), Bonn, Germany.

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July 2010

Role for LAMP-2 in endosomal cholesterol transport.

Authors:

Alexander Schneede Christine K Schmidt Maarit Hölttä-Vuori Jörg Heeren Marion Willenborg Judith Blanz Mykola Domanskyy Bernadette Breiden Susanne Brodesser Jobst Landgrebe Konrad Sandhoff Elina Ikonen Paul Saftig Eeva-Liisa Eskelinen

J Cell Mol Med 2011 Feb;15(2):280-95

Institute of Biochemistry, University of Kiel, Kiel, Germany.

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February 2011

Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila.

Authors:

Reinhard Bauer André Voelzmann Bernadette Breiden Ute Schepers Hany Farwanah Ines Hahn Franka Eckardt Konrad Sandhoff Michael Hoch

EMBO J 2009 Dec 15;28(23):3706-16. Epub 2009 Oct 15.

LIMES-Institute, Program Unit Development, Genetics & Molecular Physiology, Laboratory for Molecular Developmental Biology, University of Bonn, Bonn, Germany.

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December 2009

Saposin B-dependent reconstitution of arylsulfatase A activity in vitro and in cell culture models of metachromatic leukodystrophy.

Authors:

Ulrich Matzner Bernadette Breiden Günter Schwarzmann Afshin Yaghootfam Arvan L Fluharty Andrej Hasilik Konrad Sandhoff Volkmar Gieselmann

J Biol Chem 2009 Apr 18;284(14):9372-81. Epub 2009 Feb 18.

Institut für Physiologische Chemie and LIMES, Membrane Biology and Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, Rheinische Friedrich-Wilhelms-University, 53115 Bonn, Germany.

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April 2009

Postnatal requirement of the epithelial sodium channel for maintenance of epidermal barrier function.

Authors:

Roch-Philippe Charles Marjorie Guitard Céline Leyvraz Bernadette Breiden Marek Haftek Zofia Haftek-Terreau Jean-Christophe Stehle Konrad Sandhoff Edith Hummler

J Biol Chem 2008 Feb 26;283(5):2622-30. Epub 2007 Nov 26.

Département de Pharmacologie & de Toxicologie, Université de Lausanne, Rue du Bugnon 27, Lausanne, Switzerland.

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February 2008

Optimization of submerged keratinocyte cultures for the synthesis of barrier ceramides.

Authors:

Bernadette Breiden Hichem Gallala Thomas Doering Konrad Sandhoff

Eur J Cell Biol 2007 Dec 21;86(11-12):657-73. Epub 2007 Aug 21.

LIMES, Membrane Biology & Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany.

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December 2007