Publications by authors named "Bernadette Breiden"

35Publications

Mechanism of Secondary Ganglioside and Lipid Accumulation in Lysosomal Disease.

Int J Mol Sci 2020 Apr 7;21(7). Epub 2020 Apr 7.

Membrane Biology and Lipid Biochemistry Unit, LIMES Institute, University of Bonn, 53121 Bonn, Germany.

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April 2020

Emerging mechanisms of drug-induced phospholipidosis.

Biol Chem 2019 12;401(1):31-46

LIMES Institut, Membrane Biology and Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany.

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December 2019

Lysosomal Glycosphingolipid Storage Diseases.

Annu Rev Biochem 2019 06;88:461-485

LIMES Institute, Membrane Biology and Lipid Biochemistry Unit, Universität Bonn, D-53121 Bonn, Germany; email: ,

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June 2019

Ganglioside GM2 catabolism is inhibited by storage compounds of mucopolysaccharidoses and by cationic amphiphilic drugs.

Mol Genet Metab 2019 Sep - Oct;128(1-2):75-83. Epub 2019 May 4.

LIMES Institute, Membrane Biology & Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany. Electronic address:

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April 2020

Membrane lipids and their degradation compounds control GM2 catabolism at intralysosomal luminal vesicles.

J Lipid Res 2019 06 15;60(6):1099-1111. Epub 2019 Apr 15.

Membrane Biology and Lipid Biochemistry Unit, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.

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June 2019

Ganglioside Metabolism and Its Inherited Diseases.

Methods Mol Biol 2018 ;1804:97-141

LIMES Institute, Membrane Biology & Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Bonn, Germany.

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March 2019

Ceramide Synthase Schlank Is a Transcriptional Regulator Adapting Gene Expression to Energy Requirements.

Cell Rep 2018 01 28;22(4):967-978. Epub 2018 Jan 28.

LIMES-Institute, Unit Development, Genetics and Molecular Physiology, Department for Molecular Developmental Biology, University of Bonn, Carl-Troll-Strasse 31, 53115 Bonn, Germany. Electronic address:

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January 2018

Lipids regulate the hydrolysis of membrane bound glucosylceramide by lysosomal β-glucocerebrosidase.

J Lipid Res 2017 03 26;58(3):563-577. Epub 2017 Jan 26.

Life and Medical Sciences (LIMES) Institut, Membrane Biology and Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Bonn, Germany

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March 2017

Membrane-spanning lipids for an uncompromised monitoring of membrane fusion and intermembrane lipid transfer.

J Lipid Res 2015 Oct 11;56(10):1861-79. Epub 2015 Aug 11.

Life & Medical Sciences (LIMES) Institute, Membrane Biology & Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, D-53121 Bonn, Germany.

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October 2015

Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity.

J Lipid Res 2015 Sep 14;56(9):1747-61. Epub 2015 Jul 14.

LIMES Institute, Membrane Biology and Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, D-53121 Bonn, Germany.

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September 2015

Acid sphingomyelinase activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2.

J Lipid Res 2014 Dec 22;55(12):2606-19. Epub 2014 Oct 22.

LIMES Institute, Membrane Biology and Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, D-53121 Bonn, Germany.

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December 2014

The role of sphingolipid metabolism in cutaneous permeability barrier formation.

Biochim Biophys Acta 2014 Mar 15;1841(3):441-52. Epub 2013 Aug 15.

LIMES, Membrane Biology & Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany. Electronic address:

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March 2014

Regulation of the NPC2 protein-mediated cholesterol trafficking by membrane lipids.

J Neurochem 2011 Mar 7;116(5):702-7. Epub 2011 Jan 7.

LIMES, Membrane Biology & Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Bonn, Germany.

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March 2011

Role of endosomal membrane lipids and NPC2 in cholesterol transfer and membrane fusion.

J Lipid Res 2010 Jul 23;51(7):1747-60. Epub 2010 Feb 23.

Membrane Biology and Biochemistry Unit, Life and Medical Sciences Institute (LIMES), Bonn, Germany.

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July 2010

Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila.

EMBO J 2009 Dec 15;28(23):3706-16. Epub 2009 Oct 15.

LIMES-Institute, Program Unit Development, Genetics & Molecular Physiology, Laboratory for Molecular Developmental Biology, University of Bonn, Bonn, Germany.

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December 2009

Saposin B-dependent reconstitution of arylsulfatase A activity in vitro and in cell culture models of metachromatic leukodystrophy.

J Biol Chem 2009 Apr 18;284(14):9372-81. Epub 2009 Feb 18.

Institut für Physiologische Chemie and LIMES, Membrane Biology and Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, Rheinische Friedrich-Wilhelms-University, 53115 Bonn, Germany.

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April 2009

Postnatal requirement of the epithelial sodium channel for maintenance of epidermal barrier function.

J Biol Chem 2008 Feb 26;283(5):2622-30. Epub 2007 Nov 26.

Département de Pharmacologie & de Toxicologie, Université de Lausanne, Rue du Bugnon 27, Lausanne, Switzerland.

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February 2008

Optimization of submerged keratinocyte cultures for the synthesis of barrier ceramides.

Eur J Cell Biol 2007 Dec 21;86(11-12):657-73. Epub 2007 Aug 21.

LIMES, Membrane Biology & Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany.

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December 2007

Saposin B mobilizes lipids from cholesterol-poor and bis(monoacylglycero)phosphate-rich membranes at acidic pH. Unglycosylated patient variant saposin B lacks lipid-extraction capacity.

FEBS J 2007 Jul 11;274(13):3405-20. Epub 2007 Jun 11.

LIMES, Membrane Biology & Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, University of Bonn, Germany.

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July 2007

Development of an assay for the intermembrane transfer of cholesterol by Niemann-Pick C2 protein.

Biol Chem 2007 Jun;388(6):617-26

LIMES Membrane Biology and Lipid Biochemistry Unit, University of Bonn, c/o Kekulé Institute, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany.

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June 2007

Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation.

Nat Cell Biol 2007 Apr 11;9(4):461-9. Epub 2007 Mar 11.

Institute for Genetics, Department of Mouse Genetics and Inflammation, University of Cologne, Zülpicher Str. 47, 50674 Cologne, Germany.

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April 2007

Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis.

Immunity 2006 Jan;24(1):105-17

Department of Immunology, Max-Planck-Institute for Infection Biology, Schumannstrasse 21-22, 10117 Berlin, Germany.

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January 2006

The epidermal barrier function is dependent on the serine protease CAP1/Prss8.

J Cell Biol 2005 Aug;170(3):487-96

Département de Pharmacologie et de Toxicologie, Université de Lausanne, CH-1005 Lausanne, Switzerland.

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August 2005

Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation.

Eur J Cell Biol 2004 Dec;83(11-12):747-59

Institut für Physiologische Chemie, Universität Bonn, Bonn, Germany.

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December 2004

Physiological relevance of sphingolipid activator proteins in cultured human fibroblasts.

Biochimie 2003 Mar-Apr;85(3-4):439-48

Kekulé-Institut für Organische Chemie und Biochemie der Universität Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

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January 2004