Berislav Zlokovic

Berislav Zlokovic

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Berislav Zlokovic

Publications by authors named "Berislav Zlokovic"

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Every-other-day feeding exacerbates inflammation and neuronal deficits in 5XFAD mouse model of Alzheimer's disease.

Neurobiol Dis 2020 Jan 10;136:104745. Epub 2020 Jan 10.

Department of Neurobiology, Institute for Biological Research "Siniša Stanković"- National Institute of Republic of Serbia, University of Belgrade, Bul. despota Stefana 142, 11000 Belgrade, Serbia. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2020.104745DOI Listing
January 2020

Undetectable gadolinium brain retention in individuals with an age-dependent blood-brain barrier breakdown in the hippocampus and mild cognitive impairment.

Alzheimers Dement 2019 Dec;15(12):1568-1575

Zilkha Neurogenetic Institute, Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Alzheimer's Disease Research Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2019.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927478PMC
December 2019

Functional connectivity among brain regions affected in Alzheimer's disease is associated with CSF TNF-α in APOE4 carriers.

Neurobiol Aging 2019 Nov 5. Epub 2019 Nov 5.

Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.10.013DOI Listing
November 2019

Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming.

Cell Stem Cell 2019 Oct 12;25(4):486-500.e9. Epub 2019 Sep 12.

Eli and Edythe Broad CIRM Center, University of Southern California, 1425 San Pablo Street, Los Angeles, CA 90033, USA; Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA, USA; Zilkha Neurogenetic Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778044PMC
October 2019

Pericyte constriction underlies capillary derecruitment during hyperemia in the setting of arterial stenosis.

Am J Physiol Heart Circ Physiol 2019 Aug 24;317(2):H255-H263. Epub 2019 May 24.

Knight Cardiovascular Institute, Oregon Health & Science University , Portland, Oregon.

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http://dx.doi.org/10.1152/ajpheart.00097.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732474PMC
August 2019

TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice.

Cell Rep 2019 04;27(2):549-560.e6

Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.12.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485958PMC
April 2019

Experimental chronic cerebral hypoperfusion results in decreased pericyte coverage and increased blood-brain barrier permeability in the corpus callosum.

J Cereb Blood Flow Metab 2019 02 1;39(2):240-250. Epub 2017 Dec 1.

1 Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1177/0271678X17743670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365610PMC
February 2019

3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice.

J Exp Med 2019 02 15;216(2):279-293. Epub 2019 Jan 15.

Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA

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http://www.jem.org/lookup/doi/10.1084/jem.20181035
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http://dx.doi.org/10.1084/jem.20181035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363429PMC
February 2019

Prion Protein Antagonists Rescue Alzheimer's Amyloid-β-Related Cognitive Deficits.

Trends Mol Med 2019 02 17;25(2):74-76. Epub 2019 Jan 17.

Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377285PMC
February 2019

Blood-Brain Barrier: From Physiology to Disease and Back.

Physiol Rev 2019 01;99(1):21-78

Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California , Los Angeles, California ; and Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California , Los Angeles, California.

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https://www.physiology.org/doi/10.1152/physrev.00050.2017
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http://dx.doi.org/10.1152/physrev.00050.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335099PMC
January 2019

Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Alzheimers Dement 2019 01;15(1):158-167

Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Alzheimer's Disease Research Center, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.07.222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338083PMC
January 2019

The role of brain vasculature in neurodegenerative disorders.

Nat Neurosci 2018 10 24;21(10):1318-1331. Epub 2018 Sep 24.

Department of Physiology and Neuroscience and the Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/s41593-018-0234-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198802PMC
October 2018

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism.

Mol Neurodegener 2018 10 19;13(1):57. Epub 2018 Oct 19.

Center for Neurodegeneration and Regeneration, Zilkha Neurogenetic Institute and Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, California, 90033, USA.

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http://dx.doi.org/10.1186/s13024-018-0286-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194676PMC
October 2018

Activated protein C, protease activated receptor 1, and neuroprotection.

Blood 2018 07 4;132(2):159-169. Epub 2018 Jun 4.

The Scripps Research Institute, La Jolla, CA.

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http://dx.doi.org/10.1182/blood-2018-02-769026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043978PMC
July 2018

Permeability imaging as a predictor of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.

J Cereb Blood Flow Metab 2018 06 3;38(6):973-979. Epub 2018 Apr 3.

2 Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1177/0271678X18768670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998996PMC
June 2018

In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain.

Nat Protoc 2018 06 24;13(6):1377-1402. Epub 2018 May 24.

Department of Physiology and Neuroscience and the Zilkha Neurogenetic Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1038/nprot.2018.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402338PMC
June 2018

Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C.

Neuropharmacology 2018 05 18;134(Pt B):293-301. Epub 2017 Sep 18.

Department of Physiology and Neuroscience and the Zilkha Neurogenetic Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2017.09.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857404PMC
May 2018

Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders.

Nat Rev Neurol 2018 03 29;14(3):133-150. Epub 2018 Jan 29.

Department of Physiology and Neuroscience and the Zilkha Neurogenetic Institute, Keck School of Medicine of the University of Southern California, 1501 San Pablo Street, Los Angeles, California 90089, USA.

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http://dx.doi.org/10.1038/nrneurol.2017.188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829048PMC
March 2018

Alzheimer's disease: A matter of blood-brain barrier dysfunction?

J Exp Med 2017 Nov 23;214(11):3151-3169. Epub 2017 Oct 23.

Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, Los Angeles, CA.

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http://dx.doi.org/10.1084/jem.20171406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679168PMC
November 2017

Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-β signaling.

PLoS One 2017 25;12(4):e0176225. Epub 2017 Apr 25.

Department of Physiology and Biophysics and Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176225PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404855PMC
September 2017

Role of clusterin in the brain vascular clearance of amyloid-β.

Proc Natl Acad Sci U S A 2017 08 1;114(33):8681-8682. Epub 2017 Aug 1.

Department of Physiology and Neuroscience, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1711357114
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http://dx.doi.org/10.1073/pnas.1711357114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565473PMC
August 2017

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease.

Nat Rev Neurosci 2017 07 18;18(7):419-434. Epub 2017 May 18.

Zilkha Neurogenetic Institute, 1501 San Pablo Street, Los Angeles, California 90089, USA.

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http://dx.doi.org/10.1038/nrn.2017.48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759779PMC
July 2017

Remote control of BBB: A tale of exosomes and microRNA.

Cell Res 2017 07 19;27(7):849-850. Epub 2017 May 19.

Zilkha Neurogenetic Institute and Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1038/cr.2017.71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518990PMC
July 2017

Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain.

Nat Neurosci 2017 Mar 30;20(3):406-416. Epub 2017 Jan 30.

Department of Physiology and Biophysics and the Zilkha Neurogenetic Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1038/nn.4489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323291PMC
March 2017

Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy.

Cell Stem Cell 2016 11 11;19(5):663-671. Epub 2016 Aug 11.

Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.07.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144538PMC
November 2016

2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C.

Arterioscler Thromb Vasc Biol 2016 11 6;36(11):2143-2151. Epub 2016 Oct 6.

From the Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA (J.H.G., L.O.M., J.A.F.); Division of Hematology/Oncology, Department of Medicine, University of California, San Diego (J.H.G.); and Department of Physiology and Biophysics, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles (B.V.Z.).

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http://dx.doi.org/10.1161/ATVBAHA.116.308038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119536PMC
November 2016

3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice.

Nat Med 2016 09 22;22(9):1050-5. Epub 2016 Aug 22.

Department of Physiology and Biophysics, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1038/nm.4154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215920PMC
September 2016

Optimal acquisition and modeling parameters for accurate assessment of low Ktrans blood-brain barrier permeability using dynamic contrast-enhanced MRI.

Magn Reson Med 2016 May 16;75(5):1967-77. Epub 2015 Jun 16.

Beckman Institute, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.

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http://dx.doi.org/10.1002/mrm.25793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726482PMC
May 2016

Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease.

Biochim Biophys Acta 2016 05 17;1862(5):887-900. Epub 2015 Dec 17.

Department of Physiology and Biophysics and the Zilkha Neurogenetic Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2015.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821735PMC
May 2016

Brain imaging of neurovascular dysfunction in Alzheimer's disease.

Acta Neuropathol 2016 May 1;131(5):687-707. Epub 2016 Apr 1.

Zilkha Neurogenetic Institute and Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA.

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http://dx.doi.org/10.1007/s00401-016-1570-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283382PMC
May 2016

Activated protein C promotes neuroprotection: mechanisms and translation to the clinic.

Thromb Res 2016 May;141 Suppl 2:S62-4

Department of Neurosurgery, University of Southern California, Keck School of Medicine, Los Angeles, CA; Department of Neurosurgery, Zilkha Neurogenetic Institute, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA.

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http://dx.doi.org/10.1016/S0049-3848(16)30368-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904825PMC
May 2016

Pericytes of the neurovascular unit: key functions and signaling pathways.

Nat Neurosci 2016 05;19(6):771-83

Department of Physiology and Biophysics, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1038/nn.4288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745011PMC
May 2016

Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium.

Front Neurosci 2016 22;10:46. Epub 2016 Feb 22.

Department of Physiology and Biophysics, Keck School of Medicine, Zilkha Neurogenetic Institute, University of Southern California Los Angeles, CA, USA.

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http://dx.doi.org/10.3389/fnins.2016.00046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761864PMC
March 2016

Blood-Brain Barrier Permeability and Gadolinium: Benefits and Potential Pitfalls in Research.

JAMA Neurol 2016 Jan;73(1):13-4

Zilkha Neurogenetic Institute, Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles.

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http://dx.doi.org/10.1001/jamaneurol.2015.2960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736734PMC
January 2016

Establishment and Dysfunction of the Blood-Brain Barrier.

Cell 2015 Nov;163(5):1064-1078

Department of Physiology and Biophysics and the Zilkha Neurogenetic Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.10.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655822PMC
November 2015

Shedding of soluble platelet-derived growth factor receptor-β from human brain pericytes.

Neurosci Lett 2015 Oct 25;607:97-101. Epub 2015 Sep 25.

Department of Physiology and Biophysics, Center for Neurodegeneration and Regeneration, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2015.09.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631673PMC
October 2015

Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke.

Front Cell Neurosci 2015 2;9:344. Epub 2015 Sep 2.

Zilkha Neurogenetic Institute, Keck School of Medicine of the University of Southern California, University of Southern California Los Angeles, CA, USA.

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http://dx.doi.org/10.3389/fncel.2015.00344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556986PMC
September 2015

Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer's disease: the role, regulation and restoration of LRP1.

Front Aging Neurosci 2015 15;7:136. Epub 2015 Jul 15.

Department of Physiology and Biophysics, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California Los Angeles, CA, USA.

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http://dx.doi.org/10.3389/fnagi.2015.00136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502358PMC
August 2015

Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease.

J Cereb Blood Flow Metab 2015 Jul 22;35(7):1055-68. Epub 2015 Apr 22.

Department of Physiology and Biophysics, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/jcbfm.2015.76DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640280PMC
July 2015

ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies.

BMC Med Imaging 2015 Jun 16;15:19. Epub 2015 Jun 16.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.

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http://dx.doi.org/10.1186/s12880-015-0062-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466867PMC
June 2015

Vascular plasticity and cognition during normal aging and dementia.

JAMA Neurol 2015 May;72(5):495-6

Zilkha Neurogenetic Institute, Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles.

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http://dx.doi.org/10.1001/jamaneurol.2014.4636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428924PMC
May 2015

Activated protein C: biased for translation.

Blood 2015 May 30;125(19):2898-907. Epub 2015 Mar 30.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA;

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http://dx.doi.org/10.1182/blood-2015-02-355974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424414PMC
May 2015

7T Multi-shell Hybrid Diffusion Imaging (HYDI) for Mapping Brain Connectivity in Mice.

Proc SPIE Int Soc Opt Eng 2015 Mar;9413

Imaging Genetics Center, Institute for Neuroimaging & Informatics, University of Southern California, Los Angeles.

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http://dx.doi.org/10.1117/12.2081491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386863PMC
March 2015

Blood-brain barrier breakdown in the aging human hippocampus.

Neuron 2015 Jan;85(2):296-302

Zilkha Neurogenetic Institute and Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.12.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350773PMC
January 2015

Cytoprotective-selective activated protein C therapy for ischaemic stroke.

Thromb Haemost 2014 Nov 18;112(5):883-92. Epub 2014 Sep 18.

Laurent O. Mosnier, PhD, Department of Molecular and Experimental Medicine (MEM-180), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California, USA, Tel.: +1 858 784 2227, Fax: +1 858 784 2243, E-mail:

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http://dx.doi.org/10.1160/TH14-05-0448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356129PMC
November 2014

Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9.

Nat Commun 2014 Sep 5;5:4820. Epub 2014 Sep 5.

1] Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, HMR Room 401, 2011 Zonal Avenue, Los Angeles, California 90033, USA [2] Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, HMR Room 401, 2011 Zonal Avenue, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1038/ncomms5820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157316PMC
September 2014

Recommendations of the Alzheimer's disease-related dementias conference.

Neurology 2014 Aug 30;83(9):851-60. Epub 2014 Jul 30.

From the Department of Pathology (T.J.M.), University of Washington, Seattle; National Institute of Neurological Disorders and Stroke (W.J.K., D.B., W.R.G., A.N.K., B.-A.S., M.S., C.L.T., S.P.W., R.A.C.), Bethesda, MD; Neuropathology Lab (D.W.D.), Mayo Clinic, Jacksonville, FL; Department of Epidemiology & Biostatistics (M.M.G.), University of California San Francisco; Hemorrhagic Stroke Research Program (S.M.G.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Neurodegenerative Diseases DHT at Eli Lilly and Company (M.L.H.), Lilly Research Center, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.), Columbia University Medical Center, New York; Columbia University (J.J.M., K.S.M.), College of Physicians and Surgeons, New York, NY; University of California San Francisco Memory and Aging Center (B.L.M., W.W.S.); National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; and Zilhka Neurogenetic Institute (B.V.Z.), Center for Neurodegeneration and Regeneration and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA.

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http://dx.doi.org/10.1212/WNL.0000000000000733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155046PMC
August 2014

Pericyte loss influences Alzheimer-like neurodegeneration in mice.

Nat Commun 2013 ;4:2932

Department of Physiology and Biophysics, Keck School of Medicine, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1038/ncomms3932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945879PMC
July 2014

The pericyte: a forgotten cell type with important implications for Alzheimer's disease?

Brain Pathol 2014 Jul;24(4):371-86

Zilkha Neurogenetic Institute, University of Southern California Keck School of Medicine, Los Angeles, CA; Department of Neurosurgery, University of California San Francisco, San Francisco, CA.

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http://dx.doi.org/10.1111/bpa.12152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423607PMC
July 2014

Blood-brain barrier: a dual life of MFSD2A?

Neuron 2014 May;82(4):728-30

Zilkha Neurogenetic Institute and Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114515PMC
May 2014

Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice.

Proc Natl Acad Sci U S A 2014 Mar 3;111(11):E1035-42. Epub 2014 Mar 3.

Zilkha Neurogenetic Institute, Center for Neurodegeneration and Regeneration, Department of Physiology and Biophysics, University of Southern California, Los Angeles, CA 90089.

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http://dx.doi.org/10.1073/pnas.1401595111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964055PMC
March 2014

Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats.

Stroke 2013 Dec 24;44(12):3529-36. Epub 2013 Oct 24.

From the Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA (Y.W., Z.Z., B.V.Z.); ZZ Biotech Research Laboratory, Rochester, NY (N.C.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA (P.S.R., P.D.L.); and Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA (J.H.G.).

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.113.003350
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http://dx.doi.org/10.1161/STROKEAHA.113.003350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912991PMC
December 2013

Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown.

JAMA Neurol 2013 Sep;70(9):1198-200

Neuroscience Graduate Program, University of Southern California, Los Angeles2Department of Physiology and Biophysics, Center for Neurodegeneration and Regeneration, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles.

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http://dx.doi.org/10.1001/jamaneurol.2013.3841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047029PMC
September 2013

Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice.

Blood Cells Mol Dis 2013 Aug 29;51(2):104-8. Epub 2013 Mar 29.

Zilkha Neurogenetic Institute, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA.

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http://dx.doi.org/10.1016/j.bcmd.2013.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812054PMC
August 2013

Neurovascular defects and faulty amyloid-β vascular clearance in Alzheimer's disease.

J Alzheimers Dis 2013 ;33 Suppl 1:S87-100

Zilkha Neurogenetic Institute and Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.3233/JAD-2012-129037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416477PMC
June 2013

Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease.

Brain Pathol 2013 May 28;23(3):303-10. Epub 2012 Nov 28.

Center for Neurodegeneration and Regeneration, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1111/bpa.12004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628957PMC
May 2013

A lipoprotein receptor cluster IV mutant preferentially binds amyloid-β and regulates its clearance from the mouse brain.

J Biol Chem 2013 May 11;288(21):15154-66. Epub 2013 Apr 11.

Zilkha Neurogenetic Institute and Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1074/jbc.M112.439570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663536PMC
May 2013

Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease.

JAMA Neurol 2013 Apr;70(4):440-4

Zilkha Neurogenetic Institute, 1501 San Pablo St, Room 101, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1001/jamaneurol.2013.2152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414030PMC
April 2013

Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1.

Brain Res 2013 Apr 21;1507:97-104. Epub 2013 Feb 21.

Center for Neurodegeneration and Regeneration, Zilkha Neurogenetic Institute, Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1016/j.brainres.2013.02.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739836PMC
April 2013

A gliovascular idea for the white matter repair?

J Neurochem 2013 Apr 27;125(2):172-4. Epub 2013 Feb 27.

Center for Neurodegeneration and Regeneration, Zilkha Neurogenetic Institute, and Department of Physiology and Biophysics, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1111/jnc.12174DOI Listing
April 2013

An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway.

J Neurosci 2013 Apr;33(14):6181-90

Center for Neurodegeneration and Regeneration, Zilkha Neurogenetic Institute and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, California 90089, USA.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.4491-12.2
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http://dx.doi.org/10.1523/JNEUROSCI.4491-12.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707621PMC
April 2013

Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis.

Acta Neuropathol 2013 Jan 1;125(1):111-20. Epub 2012 Sep 1.

Center for Neurodegeneration and Regeneration, Zilkha Neurogenetic Institute, University of Southern California, Room: 101, 1501 San Pablo Street, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1007/s00401-012-1039-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535352PMC
January 2013

Low-density lipoprotein receptor-related protein 1: a physiological Aβ homeostatic mechanism with multiple therapeutic opportunities.

Pharmacol Ther 2012 Oct 20;136(1):94-105. Epub 2012 Jul 20.

Department of Physiology and Biophysics, and Center for Neurodegeneration and Regeneration at the Zilkha Neurogenetic Institute, University of Southern California, Keck School of Medicine, 1501 San Pablo Street, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1016/j.pharmthera.2012.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432694PMC
October 2012

Blood-spinal cord barrier pericyte reductions contribute to increased capillary permeability.

J Cereb Blood Flow Metab 2012 Oct 1;32(10):1841-52. Epub 2012 Aug 1.

Department of Physiology and Biophysics, University of Southern California, Zilkha Neurogenetic Institute, Center for Neurodegeneration and Regeneration, Los Angeles, California 90089, USA.

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http://dx.doi.org/10.1038/jcbfm.2012.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463878PMC
October 2012

Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease.

Cold Spring Harb Perspect Med 2012 Oct 1;2(10). Epub 2012 Oct 1.

Center for Neurodegenerative and Vascular Brain Disorders and Interdisciplinary Program in Dementia Research, Arthur Kornberg Medical Research Building, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1101/cshperspect.a011452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475405PMC
October 2012

An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents.

Stroke 2012 Sep 17;43(9):2444-9. Epub 2012 Jul 17.

Zilkha Neurogenetic Institute, University of Southern California, Keck School of Medicine, 1501 San Pablo Street, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1161/STROKEAHA.112.658997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429704PMC
September 2012

Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis.

Proc Natl Acad Sci U S A 2012 Sep 27;109(38):15502-7. Epub 2012 Aug 27.

Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458349PMC
September 2012

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.

Nature 2012 May 16;485(7399):512-6. Epub 2012 May 16.

Center for Neurodegenerative and Vascular Brain Disorders, University of Rochester Medical Center, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1038/nature11087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047116PMC
May 2012

Protein C anticoagulant and cytoprotective pathways.

Int J Hematol 2012 Apr 5;95(4):333-45. Epub 2012 Apr 5.

Department of Molecular and Experimental Medicine, MEM-180, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://link.springer.com/10.1007/s12185-012-1059-0
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413316PMC
April 2012

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders.

Nat Rev Neurosci 2011 Nov 3;12(12):723-38. Epub 2011 Nov 3.

Department of Physiology and Biophysics, and Center for Neurodegeneration and Regeneration at the Zilkha Neurogenetic Institute, University of Southern California, Keck School of Medicine, 1501 San Pablo Street, Los Angeles, California 90089, USA.

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http://dx.doi.org/10.1038/nrn3114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036520PMC
November 2011

Central nervous system pericytes in health and disease.

Nat Neurosci 2011 Oct 26;14(11):1398-1405. Epub 2011 Oct 26.

Center for Neurodegenerative and Vascular Brain Disorders, Department of Neurosurgery and Neurology, University of Rochester Medical Center, Rochester, New York, USA.

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http://dx.doi.org/10.1038/nn.2946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020628PMC
October 2011

Microhemorrhages: undetectable but clinically meaningful the question persists.

Amyotroph Lateral Scler 2011 May 17;12(3):231-2; author reply 233-4. Epub 2011 Mar 17.

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http://dx.doi.org/10.3109/17482968.2011.565776DOI Listing
May 2011

Cytoprotective protein C pathways and implications for stroke and neurological disorders.

Trends Neurosci 2011 Apr 25;34(4):198-209. Epub 2011 Feb 25.

Center for Neurodegenerative and Vascular Brain Disorders, Department of Neurological Surgery, University of Rochester Medical Center, Rochester, New York, USA.

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http://dx.doi.org/10.1016/j.tins.2011.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491752PMC
April 2011

Lack of Smad or Notch leads to a fatal game of brain pericyte hopscotch.

Dev Cell 2011 Mar;20(3):279-80

Center for Neurodegenerative and Vascular Brain Disorders, Department of Neurosurgery and Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1016/j.devcel.2011.03.002DOI Listing
March 2011