Beow Y Yeap

Beow Y Yeap

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Treatment with Next-Generation ALK Inhibitors Fuels Plasma Mutation Diversity.

Clin Cancer Res 2019 Nov 29;25(22):6662-6670. Epub 2019 Jul 29.

Massachusetts General Hospital Cancer Center and Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-1436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858956PMC
November 2019

Efficacy of Alectinib in Patients with ALK-Positive NSCLC and Symptomatic or Large CNS Metastases.

J Thorac Oncol 2019 04 7;14(4):683-690. Epub 2018 Dec 7.

Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15560864183351
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http://dx.doi.org/10.1016/j.jtho.2018.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440803PMC
April 2019

Impact of BRAF Mutation Class on Disease Characteristics and Clinical Outcomes in BRAF-mutant Lung Cancer.

Clin Cancer Res 2019 01 17;25(1):158-165. Epub 2018 Sep 17.

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-2062DOI Listing
January 2019

Clinical outcomes of patients with resected, early-stage ALK-positive lung cancer.

Lung Cancer 2018 08 22;122:67-71. Epub 2018 May 22.

Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2018.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062851PMC
August 2018

Improved Overall Survival and Locoregional Disease Control With Concurrent PD-1 Pathway Inhibitors and Stereotactic Radiosurgery for Lung Cancer Patients With Brain Metastases.

Int J Radiat Oncol Biol Phys 2018 07 22;101(3):624-629. Epub 2018 Mar 22.

Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2018.02.175DOI Listing
July 2018

Estimated IQ Systematically Underestimates Neurocognitive Sequelae in Irradiated Pediatric Brain Tumor Survivors.

Int J Radiat Oncol Biol Phys 2018 07 21;101(3):541-549. Epub 2018 Mar 21.

Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2018.03.012DOI Listing
July 2018

Asymptomatic Late-phase Radiographic Changes Among Chest-Wall Patients Are Associated With a Proton RBE Exceeding 1.1.

Int J Radiat Oncol Biol Phys 2018 07 17;101(4):809-819. Epub 2018 Apr 17.

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.ijrobp.2018.03.037DOI Listing
July 2018

Impact of EML4-ALK Variant on Resistance Mechanisms and Clinical Outcomes in ALK-Positive Lung Cancer.

J Clin Oncol 2018 04 26;36(12):1199-1206. Epub 2018 Jan 26.

Jessica J. Lin, Satoshi Yoda, Beow Y. Yeap, Ibiayi Dagogo-Jack, Nicholas A. Jessop, Ginger Y. Jiang, Long P. Le, Aaron N. Hata, Justin F. Gainor, Anthony J. Iafrate, and Alice T. Shaw, Massachusetts General Hospital, Boston; Alexa B. Schrock, Kyle Gowen, Philip J. Stephens, Jeffrey S. Ross, Siraj M. Ali, and Vincent A. Miller, Foundation Medicine, Cambridge, MA; Viola W. Zhu and Sai-Hong Ignatius Ou, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Orange, CA; Melissa L. Johnson, Sarah Cannon Research Institute; and Christine M. Lovly, Vanderbilt-Ingram Cancer Center, Nashville, TN.

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http://dx.doi.org/10.1200/JCO.2017.76.2294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903999PMC
April 2018

Quantitative Clinical Staging for Patients With Malignant Pleural Mesothelioma.

J Natl Cancer Inst 2018 03;110(3):258-264

Division of Thoracic Surgery, Brigham and Women's, Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1093/jnci/djx175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009654PMC
March 2018

Phase II Study of Proton-Based Stereotactic Body Radiation Therapy for Liver Metastases: Importance of Tumor Genotype.

J Natl Cancer Inst 2017 09;109(9)

Department of Radiation Oncology, Department of Pathology, Division of Biostatistics, Department of Medicine, Division of Medical Oncology, Department of Medicine, Department of Radiology, and Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Harvard Radiation Oncology Program, Harvard Medical School, Boston, MA; Department of Radiation Oncology, Brigham and Women's Hospital/Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1093/jnci/djx031DOI Listing
September 2017

Validation of a Gene Expression Test for Mesothelioma Prognosis in Formalin-Fixed Paraffin-Embedded Tissues.

J Mol Diagn 2017 01 15;19(1):65-71. Epub 2016 Nov 15.

Thoracic Surgery Oncology Laboratory and the International Mesothelioma Program, Division of Thoracic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2016.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225306PMC
January 2017

Proton beam therapy for medulloblastoma - Author's reply.

Lancet Oncol 2016 05 27;17(5):e174-5. Epub 2016 Apr 27.

Department of Radiation Oncology, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1016/S1470-2045(16)30061-4DOI Listing
May 2016

Multi-Institutional Phase II Study of High-Dose Hypofractionated Proton Beam Therapy in Patients With Localized, Unresectable Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma.

J Clin Oncol 2016 Feb 14;34(5):460-8. Epub 2015 Dec 14.

Theodore S. Hong, Jennifer Y. Wo, Beow Y. Yeap, Erin I. McDonnell, Lawrence S. Blaszkowsky, Eunice L. Kwak, Jill N. Allen, Jeffrey W. Clark, Lipika Goyal, Janet E. Murphy, John A. Wolfgang, Lorraine C. Drapek, Ronald S. Arellano, John T. Mullen, Sam S. Yoon, Kenneth K. Tanabe, Cristina R. Ferrone, David P. Ryan, Thomas F. DeLaney, and Andrew X. Zhu, Massachusetts General Hospital, Harvard Medical School; Harvey J. Mamon, Brigham and Women's Hospital/Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; Edgar Ben-Josef, University of Pennsylvania Hospital, Philadelphia, PA; and Milind M. Javle and Christopher H. Crane, University of Texas MD Anderson Cancer Center, Houston, TX.

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http://jco.ascopubs.org/content/early/2015/12/11/JCO.2015.64
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http://jco.ascopubs.org/content/suppl/2015/12/14/JCO.2015.64
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2015.64.2710
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http://dx.doi.org/10.1200/JCO.2015.64.2710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872014PMC
February 2016

Neurocognitive effects of proton radiation therapy in adults with low-grade glioma.

J Neurooncol 2016 Jan;126(1):157-164

Department of Radiation Oncology, Massachusetts General Hospital, 30 Fruit Street, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s11060-015-1952-5DOI Listing
January 2016

Adapting a drug screening platform to discover associations of molecular targeted radiosensitizers with genomic biomarkers.

Mol Cancer Res 2015 Apr 9;13(4):713-20. Epub 2015 Feb 9.

Laboratory of Cellular and Molecular Radiation Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts. Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410013PMC
April 2015

Proton radiation therapy for the treatment of retinoblastoma.

Int J Radiat Oncol Biol Phys 2014 Nov 13;90(4):863-9. Epub 2014 Sep 13.

Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2014.07.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253018PMC
November 2014

Quality of life outcomes in proton and photon treated pediatric brain tumor survivors.

Radiother Oncol 2014 Oct 7;113(1):89-94. Epub 2014 Oct 7.

Center for Child and Adolescent Health Policy, Massachusetts General Hospital, Department of Pediatrics, Harvard Medical School, Boston, United States.

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http://dx.doi.org/10.1016/j.radonc.2014.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288853PMC
October 2014

Long-term results of Phase II study of high dose photon/proton radiotherapy in the management of spine chordomas, chondrosarcomas, and other sarcomas.

J Surg Oncol 2014 Aug 19;110(2):115-22. Epub 2014 Apr 19.

Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/jso.23617DOI Listing
August 2014

Phase I study of urate oxidase in the reduction of acute graft-versus-host disease after myeloablative allogeneic stem cell transplantation.

Biol Blood Marrow Transplant 2014 May 12;20(5):730-4. Epub 2014 Feb 12.

Division of Hematology/Oncology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2014.02.003DOI Listing
May 2014

Gene expression ratio test distinguishes normal lung from lung tumors in solid tissue and FNA biopsies.

J Mol Diagn 2014 Mar 9;16(2):267-72. Epub 2014 Jan 9.

Thoracic Surgery Oncology Laboratory and the International Mesothelioma Program, Division of Thoracic Surgery, Brigham and Women's Hospital, Boston, Massachusetts; Department of Surgery, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2013.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937535PMC
March 2014

Clinical indications and results after chest wall resection for recurrent mesothelioma.

J Thorac Cardiovasc Surg 2013 Dec 8;146(6):1373-9; discussion 1379-80. Epub 2013 Oct 8.

Department of Cardiothoracic Surgery, Stanford University Medical School, Stanford, Calif.

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http://dx.doi.org/10.1016/j.jtcvs.2013.07.012DOI Listing
December 2013

Clinicopathologic characteristics of malignant mesotheliomas arising in patients with a history of radiation for Hodgkin and non-Hodgkin lymphoma.

J Clin Oncol 2013 Dec 18;31(36):4544-9. Epub 2013 Nov 18.

Lucian R. Chirieac, Justine A. Barletta, William G. Richards, Tamara Tilleman, Raphael Bueno, Elizabeth H. Baldini, John Godleski, and David J. Sugarbaker, Brigham and Women's Hospital; Beow Y. Yeap, Massachusetts General Hospital; and William G. Richards, Tamara Tilleman, Raphael Bueno, Elizabeth H. Baldini, and David J. Sugarbaker, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2013.49.9616DOI Listing
December 2013

Proton radiotherapy for pediatric central nervous system ependymoma: clinical outcomes for 70 patients.

Neuro Oncol 2013 Nov 6;15(11):1552-9. Epub 2013 Oct 6.

This paper was presented at the International Symposium on Pediatric Neuro-Oncology on June 24, 2012, in Toronto, Canada.Corresponding Author: Shannon MacDonald, MD, Massachusetts General Hospital, Department of Radiation Oncology, Yawkey 112, 30 Fruit Street, Boston, MA 02114.

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http://dx.doi.org/10.1093/neuonc/not121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813421PMC
November 2013

Sequential binary gene ratio tests define a novel molecular diagnostic strategy for malignant pleural mesothelioma.

Clin Cancer Res 2013 May 14;19(9):2493-502. Epub 2013 Mar 14.

The Thoracic Surgery Oncology Laboratory, and International Mesothelioma Program, Division of Thoracic Surgery, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-2117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644001PMC
May 2013

Early clinical outcomes using proton radiation for children with central nervous system atypical teratoid rhabdoid tumors.

Int J Radiat Oncol Biol Phys 2013 May 13;86(1):114-20. Epub 2013 Mar 13.

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2012.12.004DOI Listing
May 2013

Merkel cell carcinoma: 30-year experience from a single institution.

Ann Surg Oncol 2013 Apr 1;20(4):1365-73. Epub 2012 Dec 1.

Department of Surgery, Massachusetts General Hospital, Harvard Medical School, YAW 7B, 55 Fruit Street, Boston, MA 02114, USA.

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http://www.researchgate.net/profile/Genevieve_Boland/publica
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http://dx.doi.org/10.1245/s10434-012-2779-3DOI Listing
April 2013

Family history of lung cancer in never smokers with non-small-cell lung cancer and its association with tumors harboring EGFR mutations.

Lung Cancer 2013 Mar 27;79(3):193-7. Epub 2012 Dec 27.

Department of Medicine, Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.1016/j.lungcan.2012.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566317PMC
March 2013

Desmoid tumor: analysis of prognostic factors and outcomes in a surgical series.

Ann Surg Oncol 2012 Dec 11;19(13):4028-35. Epub 2012 Sep 11.

Division of Surgical Oncology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1245/s10434-012-2638-2DOI Listing
December 2012

The introduction of systematic genomic testing for patients with non-small-cell lung cancer.

J Thorac Oncol 2012 Dec;7(12):1767-1774

Department of Medical Oncology, Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1097/JTO.0b013e3182745bcbDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500523PMC
December 2012

Histologic and cytomorphologic features of ALK-rearranged lung adenocarcinomas.

Mod Pathol 2012 Nov 29;25(11):1462-72. Epub 2012 Jun 29.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1038/modpathol.2012.109DOI Listing
November 2012

Proton radiotherapy for pediatric Ewing's sarcoma: initial clinical outcomes.

Int J Radiat Oncol Biol Phys 2012 Mar 18;82(3):1142-8. Epub 2011 Aug 18.

ATreP (Provincial Agency for Proton Therapy), Trento, Italy.

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http://dx.doi.org/10.1016/j.ijrobp.2011.03.038DOI Listing
March 2012

Proton radiotherapy for parameningeal rhabdomyosarcoma: clinical outcomes and late effects.

Int J Radiat Oncol Biol Phys 2012 Feb 4;82(2):635-42. Epub 2011 Mar 4.

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2010.11.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290917PMC
February 2012

Epithelial malignant pleural mesothelioma after extrapleural pneumonectomy: stratification of survival with CT-derived tumor volume.

AJR Am J Roentgenol 2012 Feb;198(2):359-63

Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA.

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http://dx.doi.org/10.2214/AJR.11.7015DOI Listing
February 2012

Fine-needle aspiration biopsies for gene expression ratio-based diagnostic and prognostic tests in malignant pleural mesothelioma.

Clin Cancer Res 2011 Jan 18;17(2):310-6. Epub 2010 Nov 18.

The Thoracic Surgery Oncology Laboratory and International Mesothelioma Program, and Division of Thoracic Surgery, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-0806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058309PMC
January 2011

Prognostic significance of grading in lung adenocarcinoma.

Cancer 2010 Feb;116(3):659-69

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1002/cncr.24831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846761PMC
February 2010

Major depressive disorder in long-term cancer survivors: analysis of the National Comorbidity Survey Replication.

J Clin Oncol 2009 Sep 27;27(25):4130-4. Epub 2009 Jul 27.

Department of Biostatistics, Massachusetts General Hospital, Yawkey 9A, 55 Fruit St, Boston, MA 02114, USA.

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http://ascopubs.org/doi/10.1200/JCO.2008.16.2784
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http://dx.doi.org/10.1200/JCO.2008.16.2784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734424PMC
September 2009

Results and patterns of failure in patients treated with adjuvant combined chemoradiation therapy for resected pancreatic adenocarcinoma.

Cancer 2009 Aug;115(16):3640-50

Department of Radiation Oncology, Brigham and Women's Hospital, Dana Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1002/cncr.24410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808178PMC
August 2009