Benoit Viollet

Benoit Viollet

UNVERIFIED PROFILE

Are you Benoit Viollet?   Register this Author

Register author
Benoit Viollet

Benoit Viollet

Publications by authors named "Benoit Viollet"

Are you Benoit Viollet?   Register this Author

99Publications

3268Reads

26Profile Views

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus.

Nat Rev Endocrinol 2019 Oct 22;15(10):569-589. Epub 2019 Aug 22.

INSERM, U1016, Institut Cochin, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41574-019-0242-2DOI Listing
October 2019

AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR.

FASEB J 2019 Aug 19:fj201900841R. Epub 2019 Aug 19.

Nestlé Research, École Polytechnique Fédérale de Lausanne (EPFL) Innovation Park, Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.201900841RDOI Listing
August 2019

AMPK and TBC1D1 Regulate Muscle Glucose Uptake After, but Not During, Exercise and Contraction.

Diabetes 2019 Jul 22;68(7):1427-1440. Epub 2019 Apr 22.

Section of Molecular Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db19-0050DOI Listing
July 2019

Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates.

Cell Signal 2019 May 14;57:45-57. Epub 2019 Feb 14.

Nestlé Research, École Polytechnique Fédérale de Lausanne (EPFL) Innovation Park, bâtiment G, 1015 Lausanne, Switzerland; School of Life Sciences, EPFL, 1015 Lausanne, Switzerland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cellsig.2019.02.001DOI Listing
May 2019

AMP-Activated Protein Kinase Signalling.

Int J Mol Sci 2019 Feb 12;20(3). Epub 2019 Feb 12.

INSERM U1016, Institut Cochin, Department of Endocrinology, Metabolism and Diabetes (EMD), 24 rue du faubourg Saint-Jacques, 75014 Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20030766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386857PMC
February 2019

Measurement of AMPK-Induced Inhibition of Lipid Synthesis Flux in Cultured Cells.

Methods Mol Biol 2018 ;1732:363-371

UMR8104, CNRS, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-7598-3_23DOI Listing
January 2019

Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle.

Mol Metab 2018 10 25;16:24-34. Epub 2018 Jul 25.

Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK-2100, Copenhagen, Denmark. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmet.2018.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158101PMC
October 2018

The LKB1-AMPK-α1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria.

Sci Signal 2018 10 2;11(550). Epub 2018 Oct 2.

Centre for Discovery Brain Sciences and Cardiovascular Science, College of Medicine and Veterinary Medicine, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scisignal.aau0296DOI Listing
October 2018

AMPK Activation Reduces Hepatic Lipid Content by Increasing Fat Oxidation In Vivo.

Int J Mol Sci 2018 Sep 19;19(9). Epub 2018 Sep 19.

INSERM, U1016, Institut Cochin, Département d'Endocrinologie Métabolisme et Diabète, 24, rue du Faubourg Saint Jacques, 75014 Paris, France.

View Article

Download full-text PDF

Source
http://www.mdpi.com/1422-0067/19/9/2826
Publisher Site
http://dx.doi.org/10.3390/ijms19092826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164956PMC
September 2018

A functional role for AMPK in female fertility and endometrial regeneration

Reproduction 2018 Sep 12. Epub 2018 Sep 12.

Department of Animal Sciences, Center for Reproductive Biology, Washington State University, Pullman, Washington, USA

View Article

Download full-text PDF

Source
https://rep.bioscientifica.com/view/journals/rep/aop/rep-18-
Publisher Site
http://dx.doi.org/10.1530/REP-18-0372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414284PMC
September 2018

Metformin directly targets the H3K27me3 demethylase KDM6A/UTX.

Aging Cell 2018 08 8;17(4):e12772. Epub 2018 May 8.

ProCURE (Program Against Cancer Therapeutic Resistance), Metabolism & Cancer Group, Catalan Institute of Oncology, Girona, Catalonia, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/acel.12772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052472PMC
August 2018

Editorial: AMPK: New Frontiers in Human Diseases.

Curr Drug Targets 2016 ;17(8):852

Institut Cochin, INSERM U1016, CNRS UMR8104, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1389450117999160321124627DOI Listing
July 2018

Promise and challenges for direct small molecule AMPK activators.

Biochem Pharmacol 2018 07 3;153:147-158. Epub 2018 Feb 3.

INSERM, U1016, Institut Cochin, Paris, France; CNRS, UMR8104, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2018.01.049DOI Listing
July 2018

AICAR Antiproliferative Properties Involve the AMPK-Independent Activation of the Tumor Suppressors LATS 1 and 2.

Neoplasia 2018 06 3;20(6):555-562. Epub 2018 May 3.

Université de Bordeaux, IBGC UMR 5095, Bordeaux, France; Centre National de la Recherche Scientifique, IBGC UMR 5095, Bordeaux, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neo.2018.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994775PMC
June 2018

Activation of AMPK for a Break in Hepatic Lipid Accumulation and Circulating Cholesterol.

EBioMedicine 2018 05 10;31:15-16. Epub 2018 May 10.

INSERM, U1016, Institut Cochin, Paris 75014, France; CNRS, UMR8104, Paris 75014, France; Université Paris Descartes, Sorbonne Paris Cité, Paris 75014, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebiom.2018.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014063PMC
May 2018

AMPK in skeletal muscle function and metabolism.

FASEB J 2018 04 5;32(4):1741-1777. Epub 2018 Jan 5.

Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.201700442RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945561PMC
April 2018

AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development.

EBioMedicine 2018 Feb 9;28:194-209. Epub 2018 Jan 9.

INSERM, U1016, Institut Cochin, Paris 75014, France; CNRS, UMR8104, Paris 75014, France; Université Paris Descartes, Sorbonne Paris Cité, Paris 75014, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebiom.2018.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835560PMC
February 2018

LKB1 as a Gatekeeper of Hepatocyte Proliferation and Genomic Integrity during Liver Regeneration.

Cell Rep 2018 02;22(8):1994-2005

INSERM, U1016, Institut Cochin, Paris, France; CNRS, UMR8104, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2018.01.086DOI Listing
February 2018

CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation.

Mol Cell 2017 Oct;68(2):336-349.e6

Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland; Department of Physiology, University of Lausanne, 1005 Lausanne, Switzerland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2017.09.034DOI Listing
October 2017

AMP-activated Protein Kinase As a Target For Pathogens: Friends Or Foes?

Curr Drug Targets 2016 ;17(8):942-53

Institut Cochin, Inserm U1016, CNRS UMR8104, Université Paris Descartes, 24 rue du faubourg Saint Jacques 75014 Paris, France.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387108PMC
http://dx.doi.org/10.2174/1389450116666150416120559DOI Listing
September 2017

Modifying the Dietary Carbohydrate-to-Protein Ratio Alters the Postprandial Macronutrient Oxidation Pattern in Liver of AMPK-Deficient Mice.

J Nutr 2017 09 26;147(9):1669-1676. Epub 2017 Jul 26.

UMR Nutrition Physiology and Ingestive Behavior, AgroParisTech, INRA, Paris-Saclay University, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3945/jn.117.250803DOI Listing
September 2017

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs.

Nat Commun 2017 09 18;8(1):571. Epub 2017 Sep 18.

Metabolic Signalling Laboratory, St Vincent's Institute of Medical Research, University of Melbourne, Melbourne, VIC, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-017-00628-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603566PMC
September 2017

Targeting AMPK: From Ancient Drugs to New Small-Molecule Activators.

Exp Suppl 2016;107:327-350

INSERM, U1016, Institut Cochin, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-319-43589-3_13DOI Listing
June 2017

Animal Models to Study AMPK.

Exp Suppl 2016;107:441-469

INSERM U1016, Institut Cochin, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-319-43589-3_18DOI Listing
June 2017

Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK.

Diabetes 2017 03 26;66(3):598-612. Epub 2016 Oct 26.

Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark

View Article

Download full-text PDF

Source
http://diabetes.diabetesjournals.org/content/diabetes/early/
Web Search
http://dx.doi.org/10.2337/db16-0530DOI Listing
March 2017

GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis.

Biochem J 2017 03 7;474(6):983-1001. Epub 2017 Mar 7.

Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, Hans-Knöll-Straße 2, 07745 Jena, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BCJ20160980DOI Listing
March 2017

Kidney-specific genetic deletion of both AMPK α-subunits causes salt and water wasting.

Am J Physiol Renal Physiol 2017 Feb 9;312(2):F352-F365. Epub 2016 Nov 9.

Department of Pharmacology and Physiology, University of Zaragoza, Zaragoza, Spain;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajprenal.00169.2016DOI Listing
February 2017

Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation.

Mol Cell Endocrinol 2017 01 11;440:44-56. Epub 2016 Nov 11.

Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mce.2016.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228585PMC
January 2017

Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms.

Mol Cell Endocrinol 2017 01 14;440:57-68. Epub 2016 Nov 14.

Institute of Biological Chemistry, Biophysics and Bioengineering, Edinburgh Campus, Heriot-Watt University, Edinburgh EH14 4AS, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mce.2016.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228588PMC
January 2017

AMPK/α-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis.

Cell Metab 2016 10 15;24(4):542-554. Epub 2016 Sep 15.

Washington Center for Muscle Biology and Department of Animal Sciences, Washington State University, Pullman, WA 99164, USA; Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing 100194, China. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15504131163042
Publisher Site
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061633PMC
http://dx.doi.org/10.1016/j.cmet.2016.08.010DOI Listing
October 2016

Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug.

Biochim Biophys Acta 2016 08 27;1862(8):1412-22. Epub 2016 Apr 27.

Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland DD1 9SY, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbadis.2016.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894248PMC
August 2016

AMP-activated Protein Kinase Up-regulates Mitogen-activated Protein (MAP) Kinase-interacting Serine/Threonine Kinase 1a-dependent Phosphorylation of Eukaryotic Translation Initiation Factor 4E.

J Biol Chem 2016 08 13;291(33):17020-7. Epub 2016 Jul 13.

From the Department of Molecular Genetics, CARIM School of Cardiovascular Diseases and the Institute of Cell Biology, ETH Zurich, 8093 Zurich, Switzerland,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.C116.740498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016107PMC
August 2016

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status.

Circ Res 2016 Aug 14;119(5):652-65. Epub 2016 Jul 14.

From the Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School (A.R.C., D.L., M.M., C.F., C.B., A.D.M., A.K.F.W., C.C.L., G.R.) and Division of Neuroscience, Ninewells Hospital and Medical School (D.J.K.B.), MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences (K.S.), University of Dundee, Scotland, United Kingdom; Institute of Biotechnology, University of Helsinki, Finland (V.L.M., T.S., S.C.F.); INSERM U1016, Institut Cochin, CNRS UMR8104, Université Paris Descartes, Sorbonne Paris Cité, France (B.V., M.F.); and Institute of Infection, Immunity, and Inflammation, University of Glasgow, United Kingdom (V.L.M.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.116.308445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990459PMC
August 2016

AMPK Activation by A-769662 Controls IL-6 Expression in Inflammatory Arthritis.

PLoS One 2015 16;10(10):e0140452. Epub 2015 Oct 16.

Division of Rheumatology, Allergy and Immunology, UC San Diego School of Medicine, La Jolla, California, United States of America; VA San Diego Healthcare System, 3350 La Jolla Village Drive, La Jolla, California, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140452PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608670PMC
June 2016

Myeloid-Restricted AMPKα1 Promotes Host Immunity and Protects against IL-12/23p40-Dependent Lung Injury during Hookworm Infection.

J Immunol 2016 06 20;196(11):4632-40. Epub 2016 Apr 20.

Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA 94110;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1502218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875814PMC
June 2016

AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo.

Sci Rep 2016 05 27;6:26758. Epub 2016 May 27.

Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT, F-59000 Lille, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep26758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882625PMC
May 2016

AMPK Signaling Involvement for the Repression of the IL-1β-Induced Group IIA Secretory Phospholipase A2 Expression in VSMCs.

PLoS One 2015 10;10(7):e0132498. Epub 2015 Jul 10.

Sorbonne Universités, Université Pierre et Marie Curie, Biological Adaptation and Ageing (B2A) CNRS UMR8256/INSERM ERL-U1064, F-75005 Paris, France.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132498PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498592PMC
April 2016

Specific deletion of AMP-activated protein kinase (α1AMPK) in mouse Sertoli cells modifies germ cell quality.

Mol Cell Endocrinol 2016 Mar 7;423:96-112. Epub 2016 Jan 7.

Unité de Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, Centre Val de Loire, UMR85, 37380 Nouzilly, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mce.2016.01.001DOI Listing
March 2016

Mitochondrial dysfunction activates the AMPK signaling and autophagy to promote cell survival.

Genes Dis 2016 Mar 4;3(1):82-87. Epub 2016 Jan 4.

Department of Medicine, Section of Dermatology, University of Chicago, Chicago, IL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gendis.2015.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215801PMC
March 2016

AMP-activated protein kinase suppresses urate crystal-induced inflammation and transduces colchicine effects in macrophages.

Ann Rheum Dis 2016 Jan 31;75(1):286-94. Epub 2014 Oct 31.

Depatment of Medicine, UCSD, San Diego, California, USA VA San Diego Medical Center, San Diego, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/annrheumdis-2014-206074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417082PMC
January 2016

Obesity Impairs Skeletal Muscle Regeneration Through Inhibition of AMPK.

Diabetes 2016 Jan 17;65(1):188-200. Epub 2015 Sep 17.

Washington Center for Muscle Biology, Department of Animal Sciences and Department of Pharmaceutical Sciences, Washington State University, Pullman, WA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db15-0647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686944PMC
January 2016

AMPK Suppresses Vascular Inflammation In Vivo by Inhibiting Signal Transducer and Activator of Transcription-1.

Diabetes 2015 Dec 9;64(12):4285-97. Epub 2015 Apr 9.

Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db15-0107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657575PMC
December 2015

AMPKα is essential for acute exercise-induced gene responses but not for exercise training-induced adaptations in mouse skeletal muscle.

Am J Physiol Endocrinol Metab 2015 Dec 29;309(11):E900-14. Epub 2015 Sep 29.

Section of Molecular Physiology, the August Krogh Centre, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark;

View Article

Download full-text PDF

Source
http://www.physiology.org/doi/10.1152/ajpendo.00157.2015
Publisher Site
http://dx.doi.org/10.1152/ajpendo.00157.2015DOI Listing
December 2015

Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells.

PLoS One 2014 2;9(9):e106710. Epub 2014 Sep 2.

Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0106710PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152329PMC
November 2015

Biotin deprivation impairs mitochondrial structure and function and has implications for inherited metabolic disorders.

Mol Genet Metab 2015 Nov 1;116(3):204-14. Epub 2015 Sep 1.

Unidad de Genética de la Nutrición, Instituto de Investigaciones Biomédicas de la Universidad Nacional Autónoma de México y del Instituto Nacional de Pediatría, México D.F., México. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymgme.2015.08.009DOI Listing
November 2015

Therapy: Metformin takes a new route to clinical efficacy.

Nat Rev Endocrinol 2015 Jul 2;11(7):390-2. Epub 2015 Jun 2.

INSERM U1016, CNRS UMR8104 and Université Paris Descartes, 24 rue du Faubourg Saint Jacques, 75014 Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrendo.2015.85DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676264PMC
July 2015

Prior AICAR stimulation increases insulin sensitivity in mouse skeletal muscle in an AMPK-dependent manner.

Diabetes 2015 Jun 31;64(6):2042-55. Epub 2014 Dec 31.

Section of Molecular Physiology, August Krogh Centre, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db14-1402DOI Listing
June 2015

Expanding roles for AMPK in skeletal muscle plasticity.

Trends Endocrinol Metab 2015 Jun 26;26(6):275-86. Epub 2015 Mar 26.

Université Paris Descartes, Sorbonne Paris Cité, Paris, France; INSERM, U1016, Institut Cochin, Paris, France; CNRS, UMR8104, Paris, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tem.2015.02.009DOI Listing
June 2015

Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia.

Cell Rep 2015 Jun 21;11(9):1446-57. Epub 2015 May 21.

INSERM U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, 75014 Paris, France; Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, 75005 Paris, France; Equipe Labellisée Ligue Nationale Contre le Cancer (LNCC), 75013 Paris, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2015.04.063DOI Listing
June 2015

Beyond energy homeostasis: the expanding role of AMP-activated protein kinase in regulating metabolism.

Cell Metab 2015 Jun;21(6):799-804

INSERM, U1016, Institut Cochin, 75014 Paris, France; CNRS, UMR8104, 75014 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2015.05.005DOI Listing
June 2015

AMPKα is critical for enhancing skeletal muscle fatty acid utilization during in vivo exercise in mice.

FASEB J 2015 May 21;29(5):1725-38. Epub 2015 Jan 21.

*Section of Molecular Physiology, August Krogh Centre, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark; Institute of Sports Medicine, Department of Orthopedic Surgery, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; INSERM, U1016, Institute Cochin, Paris, France; Centre National de la Recherche Scientifique, Unités Mixtes de Recherche 8104, Paris, France; and Université Descartes, Sorbonne Paris Cité, Paris, France

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.14-266650DOI Listing
May 2015

Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: identification of mitochondrial fission factor as a new AMPK substrate.

Cell Signal 2015 May 13;27(5):978-88. Epub 2015 Feb 13.

Nestlé Institute of Health Sciences SA, EPFL Innovation Park, bâtiment G/H, 1015 Lausanne, Switzerland; School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08986568150004
Publisher Site
http://dx.doi.org/10.1016/j.cellsig.2015.02.008DOI Listing
May 2015

AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of Ras-transformed fibroblasts.

Oncotarget 2015 May;6(14):11833-47

Institute for Research on Cancer and Ageing of Nice (IRCAN), University of Nice-Sophia Antipolis, CNRS UMR INSERM, Centre Antoine Lacassagne, Nice, France.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494908PMC
http://dx.doi.org/10.18632/oncotarget.3738DOI Listing
May 2015

Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo.

Nat Med 2015 Apr 23;21(4):373-82. Epub 2015 Mar 23.

1] Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA. [2] Key Laboratory of Hubei Province on Cardio-Cerebral Diseases, Hubei University of Science and Technology, Xianning, Hubei, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm.3826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390501PMC
April 2015

Mitochondrial dysfunction in primary human fibroblasts triggers an adaptive cell survival program that requires AMPK-α.

Biochim Biophys Acta 2015 Mar 20;1852(3):529-40. Epub 2014 Dec 20.

Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbadis.2014.12.012DOI Listing
March 2015

Translational tolerance of mitochondrial genes to metabolic energy stress involves TISU and eIF1-eIF4GI cooperation in start codon selection.

Cell Metab 2015 Mar;21(3):479-92

Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2015.02.010DOI Listing
March 2015

Leishmania infantum modulates host macrophage mitochondrial metabolism by hijacking the SIRT1-AMPK axis.

PLoS Pathog 2015 Mar 4;11(3):e1004684. Epub 2015 Mar 4.

Parasite Disease Group, IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal; Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1004684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349736PMC
March 2015

Apoptolidins A and C activate AMPK in metabolically sensitive cell types and are mechanistically distinct from oligomycin A.

Biochem Pharmacol 2015 Feb 12;93(3):251-65. Epub 2014 Dec 12.

Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2014.11.015DOI Listing
February 2015

Direct binding of arsenic trioxide to AMPK and generation of inhibitory effects on acute myeloid leukemia precursors.

Mol Cancer Ther 2015 Jan 24;14(1):202-12. Epub 2014 Oct 24.

Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois. Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Division of Hematology-Oncology, Department of Medicine, Jesse Brown VA Medical Center, Chicago, Illinois.

View Article

Download full-text PDF

Source
http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-14
Publisher Site
http://dx.doi.org/10.1158/1535-7163.MCT-14-0665-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297272PMC
January 2015

The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo.

Immunity 2015 Jan 2;42(1):41-54. Epub 2015 Jan 2.

Goodman Cancer Research Centre, McGill University, Montreal, QC, H3G 1Y6, Canada; Department of Physiology, McGill University, Montreal, QC, H3G 1Y6, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2014.12.030DOI Listing
January 2015

Metformin: from mechanisms of action to therapies.

Cell Metab 2014 Dec 30;20(6):953-66. Epub 2014 Oct 30.

INSERM, U1016, Institut Cochin, Paris, France; CNRS, UMR8104, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2014.09.018DOI Listing
December 2014

PRKAA1/AMPKα1 is required for autophagy-dependent mitochondrial clearance during erythrocyte maturation.

Autophagy 2014 Sep 19;10(9):1522-34. Epub 2014 Jun 19.

Section of Molecular Medicine; Department of Medicine; University of Oklahoma Health Sciences Center; Oklahoma City, OK USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/auto.29197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206532PMC
September 2014

LKB1 and AMPK regulate synaptic remodeling in old age.

Nat Neurosci 2014 Sep 3;17(9):1190-7. Epub 2014 Aug 3.

Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nn.3772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369022PMC
September 2014

Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK.

Chem Biol 2014 Jul;21(7):866-79

MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH Scotland, UK; Nestlé Institute of Health Sciences SA, EPFL Innovation Park, bâtiment G, 1015 Lausanne, Switzerland. Electronic address:

View Article

Download full-text PDF

Source
http://www.cell.com/ccbio/pdf/S1074-5521(14)00202-6.pdf
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S107455211400202
Publisher Site
http://dx.doi.org/10.1016/j.chembiol.2014.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104029PMC
July 2014