Benoit Laleu

Benoit Laleu

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Benoit Laleu

Benoit Laleu

Publications by authors named "Benoit Laleu"

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26Publications

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The Development Process for Discovery and Clinical Advancement of Modern Antimalarials.

J Med Chem 2019 Dec 20;62(23):10526-10562. Epub 2019 Aug 20.

The Walter and Eliza Hall Institute of Medical Research , Parkville , Victoria 3052 , Australia.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00761DOI Listing
December 2019

Early Antischistosomal Leads Identified from in Vitro and in Vivo Screening of the Medicines for Malaria Venture Pathogen Box.

ACS Infect Dis 2019 01 16;5(1):102-110. Epub 2018 Nov 16.

Department of Medical Parasitology and Infection Biology , Swiss Tropical and Public Health Institute , Basel , Switzerland.

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http://pubs.acs.org/doi/10.1021/acsinfecdis.8b00220
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http://dx.doi.org/10.1021/acsinfecdis.8b00220DOI Listing
January 2019

Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against Schistosoma mansoni.

Parasit Vectors 2018 05 15;11(1):298. Epub 2018 May 15.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, P.O. Box, CH-4002, Basel, Switzerland.

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-018-2855-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952519PMC
May 2018

In vitro screening of the open source Pathogen Box identifies novel compounds with profound activities against Neospora caninum.

Int J Parasitol 2017 10 25;47(12):801-809. Epub 2017 Jul 25.

Institute for Parasitology, Vetsuisse Faculty, University of Bern, Bern, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.ijpara.2017.06.002DOI Listing
October 2017

Screening of TB Actives for Activity against Nontuberculous Mycobacteria Delivers High Hit Rates.

Front Microbiol 2017 15;8:1539. Epub 2017 Aug 15.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of SingaporeSingapore.

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http://dx.doi.org/10.3389/fmicb.2017.01539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559473PMC
August 2017

Screening of the 'Pathogen Box' identifies an approved pesticide with major anthelmintic activity against the barber's pole worm.

Int J Parasitol Drugs Drug Resist 2016 12 28;6(3):329-334. Epub 2016 Jul 28.

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ijpddr.2016.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5196485PMC
December 2016

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:
Wesley C Van Voorhis John H Adams Roberto Adelfio Vida Ahyong Myles H Akabas Pietro Alano Aintzane Alday Yesmalie Alemán Resto Aishah Alsibaee Ainhoa Alzualde Katherine T Andrews Simon V Avery Vicky M Avery Lawrence Ayong Mark Baker Stephen Baker Choukri Ben Mamoun Sangeeta Bhatia Quentin Bickle Lotfi Bounaadja Tana Bowling Jürgen Bosch Lauren E Boucher Fabrice F Boyom Jose Brea Marian Brennan Audrey Burton Conor R Caffrey Grazia Camarda Manuela Carrasquilla Dee Carter Maria Belen Cassera Ken Chih-Chien Cheng Worathad Chindaudomsate Anthony Chubb Beatrice L Colon Daisy D Colón-López Yolanda Corbett Gregory J Crowther Noemi Cowan Sarah D'Alessandro Na Le Dang Michael Delves Joseph L DeRisi Alan Y Du Sandra Duffy Shimaa Abd El-Salam El-Sayed Michael T Ferdig José A Fernández Robledo David A Fidock Isabelle Florent Patrick V T Fokou Ani Galstian Francisco Javier Gamo Suzanne Gokool Ben Gold Todd Golub Gregory M Goldgof Rajarshi Guha W Armand Guiguemde Nil Gural R Kiplin Guy Michael A E Hansen Kirsten K Hanson Andrew Hemphill Rob Hooft van Huijsduijnen Takaaki Horii Paul Horrocks Tyler B Hughes Christopher Huston Ikuo Igarashi Katrin Ingram-Sieber Maurice A Itoe Ajit Jadhav Amornrat Naranuntarat Jensen Laran T Jensen Rays H Y Jiang Annette Kaiser Jennifer Keiser Thomas Ketas Sebastien Kicka Sunyoung Kim Kiaran Kirk Vidya P Kumar Dennis E Kyle Maria Jose Lafuente Scott Landfear Nathan Lee Sukjun Lee Adele M Lehane Fengwu Li David Little Liqiong Liu Manuel Llinás Maria I Loza Aristea Lubar Leonardo Lucantoni Isabelle Lucet Louis Maes Dalu Mancama Nuha R Mansour Sandra March Sheena McGowan Iset Medina Vera Stephan Meister Luke Mercer Jordi Mestres Alvine N Mfopa Raj N Misra Seunghyun Moon John P Moore Francielly Morais Rodrigues da Costa Joachim Müller Arantza Muriana Stephen Nakazawa Hewitt Bakela Nare Carl Nathan Nathalie Narraidoo Sujeevi Nawaratna Kayode K Ojo Diana Ortiz Gordana Panic George Papadatos Silvia Parapini Kailash Patra Ngoc Pham Sarah Prats David M Plouffe Sally-Ann Poulsen Anupam Pradhan Celia Quevedo Ronald J Quinn Christopher A Rice Mohamed Abdo Rizk Andrea Ruecker Robert St Onge Rafaela Salgado Ferreira Jasmeet Samra Natalie G Robinett Ulrich Schlecht Marjorie Schmitt Filipe Silva Villela Francesco Silvestrini Robert Sinden Dennis A Smith Thierry Soldati Andreas Spitzmüller Serge Maximilian Stamm David J Sullivan William Sullivan Sundari Suresh Brian M Suzuki Yo Suzuki S Joshua Swamidass Donatella Taramelli Lauve R Y Tchokouaha Anjo Theron David Thomas Kathryn F Tonissen Simon Townson Abhai K Tripathi Valentin Trofimov Kenneth O Udenze Imran Ullah Cindy Vallieres Edgar Vigil Joseph M Vinetz Phat Voong Vinh Hoan Vu Nao-Aki Watanabe Kate Weatherby Pamela M White Andrew F Wilks Elizabeth A Winzeler Edward Wojcik Melanie Wree Wesley Wu Naoaki Yokoyama Paul H A Zollo Nada Abla Benjamin Blasco Jeremy Burrows Benoît Laleu Didier Leroy Thomas Spangenberg Timothy Wells Paul A Willis

PLoS Pathog 2016 07 28;12(7):e1005763. Epub 2016 Jul 28.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1005763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965013PMC
July 2016

Chiral selectivity in the binding of [4]helicene derivatives to double-stranded DNA.

Chemistry 2013 May 9;19(22):7173-80. Epub 2013 Apr 9.

Department of Physical Chemistry, University of Geneva, 30, quai Ernerst-Ansermet, 1211 Genève 4, Switzerland.

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http://dx.doi.org/10.1002/chem.201203915DOI Listing
May 2013

Excited-state properties of chiral [4]helicene cations.

Photochem Photobiol Sci 2012 Apr 16;11(4):623-31. Epub 2012 Jan 16.

Department of Physical Chemistry, University of Geneva, CH-1211, Geneva 4, Switzerland.

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http://dx.doi.org/10.1039/c2pp05361fDOI Listing
April 2012

Vicinal diphosphoniums: electrostatic repulsion under covalent constraint.

Dalton Trans 2009 Oct 6(40):8493-508. Epub 2009 Aug 6.

CNRS, LCC (Laboratoire de Chimie de Coordination), 205, route de Narbonne, F-31077, Toulouse, France.

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http://dx.doi.org/10.1039/b903933cDOI Listing
October 2009

Exploiting the divergent reactivity of aryl-palladium intermediates for the rapid assembly of fluorene and phenanthrene derivatives.

Angew Chem Int Ed Engl 2009 ;48(10):1849-52

Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada.

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http://dx.doi.org/10.1002/anie.200805780DOI Listing
April 2009

Synthesis of annulated 2H-indazoles and 1,2,3- and 1,2,4-triazoles via a one-pot palladium-catalyzed alkylation/direct arylation reaction.

J Org Chem 2008 Nov 24;73(22):9164-7. Epub 2008 Oct 24.

Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George St., Toronto, Ontario, M5S 3H6, Canada.

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http://dx.doi.org/10.1021/jo8017236DOI Listing
November 2008

Tris(2,4,6-trimethoxyphenyl)methyl carbenium ion for charge derivatization of amines and amino acids.

J Mass Spectrom 2008 May;43(5):623-7

Department of Chemistry, Technion Israel Institute of Technology, Haifa, Israel.

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http://dx.doi.org/10.1002/jms.1360DOI Listing
May 2008

A palladium-catalyzed alkylation/direct arylation synthesis of nitrogen-containing heterocycles.

J Org Chem 2008 Mar 9;73(5):1888-97. Epub 2008 Feb 9.

Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, M5S 3H6 Canada.

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http://dx.doi.org/10.1021/jo702052bDOI Listing
March 2008

Effective HPLC resolution of [4]heterohelicenium dyes on chiral stationary phases using reversed-phase eluents.

Chirality 2007 Aug;19(8):601-6

Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università di Roma La Sapienza, Roma, Italy.

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http://dx.doi.org/10.1002/chir.20345DOI Listing
August 2007

Trimesitylmethylphosphonium cation. Supramolecular stereocontrol and simple enantiomerization mechanism determination.

J Org Chem 2006 Sep;71(19):7412-6

Département de Chimie Organique, Université de Genève, quai Ernest-Ansermet 30, 1211 Genève 4, Switzerland.

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http://dx.doi.org/10.1021/jo061097wDOI Listing
September 2006

Pummerer fragmentation vs. pummerer rearrangement: a mechanistic analysis.

Chem Commun (Camb) 2006 Jul(26):2786-8

Department of Organic Chemistry, University of Geneva, Quai E. Ansermet 30, CH-1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1039/b605187aDOI Listing
July 2006

Resolution of [4]heterohelicenium dyes with unprecedented Pummerer-like chemistry.

Angew Chem Int Ed Engl 2005 Mar;44(12):1879-83

Department of Organic Chemistry, University of Geneva quai Ernest Ansermet 30, 1211 Genève 4, Switzerland.

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http://dx.doi.org/10.1002/anie.200462321DOI Listing
March 2005

Bent structure and dynamic stereochemistry of chiral acridinium cations.

J Org Chem 2003 Aug;68(16):6304-8

Département de Chimie Organique, Université de Genève, quai Ernest-Ansermet 30, CH-1211 Genève 4, Switzerland.

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http://dx.doi.org/10.1021/jo0345998DOI Listing
August 2003