Benoit J Arsenault

Benoit J Arsenault

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Benoit J Arsenault

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A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity.

NPJ Genom Med 2019 20;4:23. Epub 2019 Sep 20.

1Laboratory of Cardiovascular Pathobiology, Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec, Canada.

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http://dx.doi.org/10.1038/s41525-019-0097-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754413PMC
September 2019

apoB/apoA-I Ratio and Lp(a) Associations With Aortic Valve Stenosis Incidence: Insights From the EPIC-Norfolk Prospective Population Study.

J Am Heart Assoc 2019 Aug 13;8(16):e013020. Epub 2019 Aug 13.

Department of Cardiology Amsterdam Cardiovascular Sciences Amsterdam UMC University of Amsterdam Amsterdam The Netherlands.

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http://dx.doi.org/10.1161/JAHA.119.013020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759902PMC
August 2019

Activated platelets promote an osteogenic programme and the progression of calcific aortic valve stenosis.

Eur Heart J 2019 May;40(17):1362-1373

Laboratory of Cardiovascular Pathobiology, Department of Surgery, Quebec Heart and Lung Institute/Research Center, Laval University, 2725 chemin Ste-Foy, Quebec, Canada.

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http://dx.doi.org/10.1093/eurheartj/ehy696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492053PMC
May 2019

Subsequent Event Risk in Individuals With Established Coronary Heart Disease.

Authors:
Riyaz S Patel Vinicius Tragante Amand F Schmidt Raymond O McCubrey Michael V Holmes Laurence J Howe Kenan Direk Axel Åkerblom Karin Leander Salim S Virani Karol A Kaminski Jochen D Muehlschlegel Hooman Allayee Peter Almgren Maris Alver Ekaterina V Baranova Hassan Behloui Bram Boeckx Peter S Braund Lutz P Breitling Graciela Delgado Nubia E Duarte Marie-Pierre Dubé Line Dufresne Niclas Eriksson Luisa Foco Markus Scholz Crystel M Gijsberts Charlotte Glinge Yan Gong Jaana Hartiala Mahyar Heydarpour Jaroslav A Hubacek Marcus Kleber Daniel Kofink Salma Kotti Pekka Kuukasjärvi Vei-Vei Lee Andreas Leiherer Petra A Lenzini Daniel Levin Leo-Pekka Lyytikäinen Nicola Martinelli Ute Mons Christopher P Nelson Kjell Nikus Anna P Pilbrow Rafal Ploski Yan V Sun Michael W T Tanck W H Wilson Tang Stella Trompet Sander W van der Laan Jessica Van Setten Ragnar O Vilmundarson Chiara Viviani Anselmi Efthymia Vlachopoulou Lawien Al Ali Eric Boerwinkle Carlo Briguori John F Carlquist Kathryn F Carruthers Gavino Casu John Deanfield Panos Deloukas Frank Dudbridge Thomas Engstrøm Natalie Fitzpatrick Kim Fox Bruna Gigante Stefan James Marja-Liisa Lokki Paulo A Lotufo Nicola Marziliano Ify R Mordi Joseph B Muhlestein Christopher Newton-Cheh Jan Pitha Christoph H Saely Ayman Samman-Tahhan Pratik B Sandesara Andrej Teren Adam Timmis Frans Van de Werf Els Wauters Arthur A M Wilde Ian Ford David J Stott Ale Algra Maria G Andreassi Diego Ardissino Benoit J Arsenault Christie M Ballantyne Thomas O Bergmeijer Connie R Bezzina Simon C Body Eric H Boersma Peter Bogaty Michiel L Bots Hermann Brenner Jasper J Brugts Ralph Burkhardt Clara Carpeggiani Gianluigi Condorelli Rhonda M Cooper-DeHoff Sharon Cresci Nicolas Danchin Ulf de Faire Robert N Doughty Heinz Drexel James C Engert Keith A A Fox Domenico Girelli Diederick E Grobbee Emil Hagström Stanley L Hazen Claes Held Harry Hemingway Imo E Hoefer G Kees Hovingh Reza Jabbari Julie A Johnson J Wouter Jukema Marcin P Kaczor Mika Kähönen Jiri Kettner Marek Kiliszek Olaf H Klungel Bo Lagerqvist Diether Lambrechts Jari O Laurikka Terho Lehtimäki Daniel Lindholm B K Mahmoodi Anke H Maitland-van der Zee Ruth McPherson Olle Melander Andres Metspalu Anna Niemcunowicz-Janica Oliviero Olivieri Grzegorz Opolski Colin N Palmer Gerard Pasterkamp Carl J Pepine Alexandre C Pereira Louise Pilote Arshed A Quyyumi A Mark Richards Marek Sanak Agneta Siegbahn Tabassome Simon Juha Sinisalo J Gustav Smith John A Spertus Steen Stender Alexandre F R Stewart Wojciech Szczeklik Anna Szpakowicz Jean-Claude Tardif Jurriën M Ten Berg Jacob Tfelt-Hansen George Thanassoulis Joachim Thiery Christian Torp-Pedersen Yolanda van der Graaf Frank L J Visseren Johannes Waltenberger Peter E Weeke Pim Van der Harst Chim C Lang Naveed Sattar Vicky A Cameron Jeffrey L Anderson James M Brophy Guillaume Pare Benjamin D Horne Winfried März Lars Wallentin Nilesh J Samani Aroon D Hingorani Folkert W Asselbergs

Circ Genom Precis Med 2019 Apr 21;12(4):e002470. Epub 2019 Mar 21.

Institute of Health Informatics (N.F., A. Timmis, H.H., F.W.A.), Faculty of Population Health Science, University College London, United Kingdom.

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http://dx.doi.org/10.1161/CIRCGEN.119.002470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629546PMC
April 2019

Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events.

Authors:
Riyaz S Patel Amand F Schmidt Vinicius Tragante Raymond O McCubrey Michael V Holmes Laurence J Howe Kenan Direk Axel Åkerblom Karin Leander Salim S Virani Karol A Kaminski Jochen D Muehlschlegel Marie-Pierre Dubé Hooman Allayee Peter Almgren Maris Alver Ekaterina V Baranova Hassan Behlouli Bram Boeckx Peter S Braund Lutz P Breitling Graciela Delgado Nubia E Duarte Line Dufresne Niclas Eriksson Luisa Foco Crystel M Gijsberts Yan Gong Jaana Hartiala Mahyar Heydarpour Jaroslav A Hubacek Marcus Kleber Daniel Kofink Pekka Kuukasjärvi Vei-Vei Lee Andreas Leiherer Petra A Lenzini Daniel Levin Leo-Pekka Lyytikäinen Nicola Martinelli Ute Mons Christopher P Nelson Kjell Nikus Anna P Pilbrow Rafal Ploski Yan V Sun Michael W T Tanck W H Wilson Tang Stella Trompet Sander W van der Laan Jessica van Setten Ragnar O Vilmundarson Chiara Viviani Anselmi Efthymia Vlachopoulou Eric Boerwinkle Carlo Briguori John F Carlquist Kathryn F Carruthers Gavino Casu John Deanfield Panos Deloukas Frank Dudbridge Natalie Fitzpatrick Bruna Gigante Stefan James Marja-Liisa Lokki Paulo A Lotufo Nicola Marziliano Ify R Mordi Joseph B Muhlestein Chris Newton Cheh Jan Pitha Christoph H Saely Ayman Samman-Tahhan Pratik B Sandesara Andrej Teren Adam Timmis Frans Van de Werf Els Wauters Arthur A M Wilde Ian Ford David J Stott Ale Algra Maria G Andreassi Diego Ardissino Benoit J Arsenault Christie M Ballantyne Thomas O Bergmeijer Connie R Bezzina Simon C Body Peter Bogaty Gert J de Borst Hermann Brenner Ralph Burkhardt Clara Carpeggiani Gianluigi Condorelli Rhonda M Cooper-DeHoff Sharon Cresci Ulf de Faire Robert N Doughty Heinz Drexel James C Engert Keith A A Fox Domenico Girelli Emil Hagström Stanley L Hazen Claes Held Harry Hemingway Imo E Hoefer G Kees Hovingh Julie A Johnson Pim A de Jong J Wouter Jukema Marcin P Kaczor Mika Kähönen Jiri Kettner Marek Kiliszek Olaf H Klungel Bo Lagerqvist Diether Lambrechts Jari O Laurikka Terho Lehtimäki Daniel Lindholm Bakhtawar K Mahmoodi Anke H Maitland-van der Zee Ruth McPherson Olle Melander Andres Metspalu Witold Pepinski Oliviero Olivieri Grzegorz Opolski Colin N Palmer Gerard Pasterkamp Carl J Pepine Alexandre C Pereira Louise Pilote Arshed A Quyyumi A Mark Richards Marek Sanak Markus Scholz Agneta Siegbahn Juha Sinisalo J Gustav Smith John A Spertus Alexandre F R Stewart Wojciech Szczeklik Anna Szpakowicz Jurriën M Ten Berg George Thanassoulis Joachim Thiery Yolanda van der Graaf Frank L J Visseren Johannes Waltenberger Pim Van der Harst Jean-Claude Tardif Naveed Sattar Chim C Lang Guillaume Pare James M Brophy Jeffrey L Anderson Winfried März Lars Wallentin Vicky A Cameron Benjamin D Horne Nilesh J Samani Aroon D Hingorani Folkert W Asselbergs

Circ Genom Precis Med 2019 Apr 21;12(4):e002471. Epub 2019 Mar 21.

Institute of Cardiovascular Science, Faculty of Population Health Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A.).

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http://dx.doi.org/10.1161/CIRCGEN.119.002471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625876PMC
April 2019

Mortality in the Familial Atherosclerosis Treatment Study-Observational Study.

J Clin Lipidol 2017 Jan - Feb;11(1):309-310. Epub 2017 Jan 23.

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Canada; Department of Medicine, Faculty of Medicine, Université Laval, Québec, Canada.

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http://dx.doi.org/10.1016/j.jacl.2017.01.008DOI Listing
October 2018

Impact of a one-year lifestyle modification program on cholesterol efflux capacities in men with abdominal obesity and dyslipidemia.

Am J Physiol Endocrinol Metab 2018 10 5;315(4):E460-E468. Epub 2018 Jun 5.

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Quebec, QC, Canada.

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http://dx.doi.org/10.1152/ajpendo.00127.2018DOI Listing
October 2018

Soluble CD14 is associated with the structural failure of bioprostheses.

Clin Chim Acta 2018 Oct 30;485:173-177. Epub 2018 Jun 30.

Laboratory of Cardiovascular Pathobiology, Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2018.06.045DOI Listing
October 2018

Life's simple 7 and calcific aortic valve stenosis incidence in apparently healthy men and women.

Int J Cardiol 2018 Oct 24;269:226-228. Epub 2018 Jul 24.

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Canada; Department of Medicine, Faculty of Medicine, Université Laval, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2018.07.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481556PMC
October 2018

Therapeutic Agents Targeting Cardiometabolic Risk for Preventing and Treating Atherosclerotic Cardiovascular Diseases.

Clin Pharmacol Ther 2018 08 19;104(2):257-268. Epub 2018 Jun 19.

Department of Cardiovascular Medicine, Cleveland Clinic, Ohio, USA.

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http://dx.doi.org/10.1002/cpt.1110DOI Listing
August 2018

Hemodynamic Deterioration of Surgically Implanted Bioprosthetic Aortic Valves.

J Am Coll Cardiol 2018 07 9;72(3):241-251. Epub 2018 Jul 9.

Institut Universitaire de Cardiologie et de Pneumologie de Québec/Québec Heart & Lung Institute, Laval University, Quebec City, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2018.04.064DOI Listing
July 2018

Saturated Fats from Butter but Not from Cheese Increase HDL-Mediated Cholesterol Efflux Capacity from J774 Macrophages in Men and Women with Abdominal Obesity.

J Nutr 2018 04;148(4):573-580

Institute of Nutrition and Functional Foods (INAF), School of Nutrition, Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ) and Department of Medicine, Department of Social and Preventive Medicine, CHU de Quebec Research Center, and Department of Kinesiology, Faculty of Medicine, Laval University, Quebec, Canada.

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http://dx.doi.org/10.1093/jn/nxy014DOI Listing
April 2018

Do Oxidized Lipoproteins Cause Atherosclerotic Cardiovascular Diseases?

Can J Cardiol 2017 12 6;33(12):1513-1516. Epub 2017 Oct 6.

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec City, Québec, Canada; Department of Surgery, Faculty of Medicine, Université Laval, Québec City, Québec, Canada.

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http://dx.doi.org/10.1016/j.cjca.2017.09.016DOI Listing
December 2017

Impact of a 1-year lifestyle modification program on plasma lipoprotein and PCSK9 concentrations in patients with coronary artery disease.

J Clin Lipidol 2016 Nov - Dec;10(6):1353-1361. Epub 2016 Sep 2.

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Quebec City, Québec, Canada; Department of medicine, Faculty of Medicine, Université Laval, Quebec City, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2016.08.014DOI Listing
October 2017

Pathobiology of Lp(a) in calcific aortic valve disease.

Expert Rev Cardiovasc Ther 2017 Oct 24;15(10):797-807. Epub 2017 Aug 24.

d Robarts Research Institute , London , ON , Canada.

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http://dx.doi.org/10.1080/14779072.2017.1367286DOI Listing
October 2017

OxLDL-derived lysophosphatidic acid promotes the progression of aortic valve stenosis through a LPAR1-RhoA-NF-κB pathway.

Cardiovasc Res 2017 Sep;113(11):1351-1363

Laboratory of Cardiovascular Pathobiology, Institut Universitaire de Cardiologie et de Pneumologie de Québec/Quebec Heart and Lung Institute, Research Center, Department of Surgery, Laval University, 2725 Chemin Ste-Foy, Quebec, Quebec G1V-4G5, Canada.

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http://dx.doi.org/10.1093/cvr/cvx089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852522PMC
September 2017

Lipoprotein(a) and coronary atheroma progression rates during long-term high-intensity statin therapy: Insights from SATURN.

Atherosclerosis 2017 Aug 15;263:137-144. Epub 2017 Jun 15.

Cleveland Clinic Coordinating Center for Clinical Research (C5R), Cleveland Clinic, Cleveland, OH, United States; Department of Medicine, University of Adelaide, Adelaide, Australia; South Australian Health and Medical Research Institute, Adelaide, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2017.06.026DOI Listing
August 2017

Precision Nutrition: A Review of Personalized Nutritional Approaches for the Prevention and Management of Metabolic Syndrome.

Nutrients 2017 Aug 22;9(8). Epub 2017 Aug 22.

Institute of Nutrition and Functional Foods (INAF), Laval University, Quebec City, QC G1V 0A6, Canada.

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http://dx.doi.org/10.3390/nu9080913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579706PMC
August 2017

CAVD: civilization aortic valve disease.

Eur Heart J 2017 07;38(28):2198-2200

Department of Medicine, Laval University, Quebec, Canada.

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http://dx.doi.org/10.1093/eurheartj/ehx219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837646PMC
July 2017

Targeting Overconsumption of Sugar-Sweetened Beverages vs. Overall Poor Diet Quality for Cardiometabolic Diseases Risk Prevention: Place Your Bets!

Nutrients 2017 Jun 13;9(6). Epub 2017 Jun 13.

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Y-2110, Pavillon Marguerite D'Youville, 2725 chemin Ste-Foy, Québec City, QC G1V 4G5, Canada.

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http://dx.doi.org/10.3390/nu9060600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490579PMC
June 2017

Does lifestyle contribute to disease severity in patients with inherited lipid disorders?

Curr Opin Lipidol 2017 Apr;28(2):177-185

aCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec bDepartment of Medicine, Faculty of Medicine, Université Laval cInstitute of Nutrition and Functional Foods, Université Laval dLipid Research Center, CHU de Québec-Université Laval, Québec, Canada.

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http://dx.doi.org/10.1097/MOL.0000000000000387DOI Listing
April 2017

Cardiovascular disease prevention: lifestyle attenuation of genetic risk.

Nat Rev Cardiol 2017 04 16;14(4):187-188. Epub 2017 Feb 16.

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Y-2110, Pavillon Marguerite D'Youville, 2725 chemin Ste-Foy, Québec G1V 4G5, Canada.

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http://dx.doi.org/10.1038/nrcardio.2017.20DOI Listing
April 2017

Carriers of the PCSK9 R46L Variant Are Characterized by an Antiatherogenic Lipoprotein Profile Assessed by Nuclear Magnetic Resonance Spectroscopy-Brief Report.

Arterioscler Thromb Vasc Biol 2017 01 17;37(1):43-48. Epub 2016 Nov 17.

From the Department of Vascular Medicine (R.V., G.K.H., J.J.P.K.) and Department of Cardiology (S.M.B.), Academic Medical Centre, Amsterdam, The Netherlands; Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Canada (M.B., B.J.A.); Department of Medicine, Faculty of Medicine, Université Laval, Québec, Canada (M.B., B.J.A.); Medical Research Council Epidemiology Unit, Cambridge, United Kingdom (N.W.); and Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, United Kingdom (K.-T.K.).

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http://dx.doi.org/10.1161/ATVBAHA.116.307995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284798PMC
January 2017

Ideal cardiovascular health influences cardiovascular disease risk associated with high lipoprotein(a) levels and genotype: The EPIC-Norfolk prospective population study.

Atherosclerosis 2017 01 11;256:47-52. Epub 2016 Nov 11.

Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Canada; Department of Medicine, Faculty of Medicine, Université Laval, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321848PMC
January 2017

Association between plasma lipoprotein levels and bioprosthetic valve structural degeneration.

Heart 2016 12 4;102(23):1915-1921. Epub 2016 Jul 4.

Laboratory of Cardiovascular Pathobiology, Department of Surgery, Quebec Heart and Lung Institute/Research Center, Laval University, Quebec, Quebec, Canada.

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http://dx.doi.org/10.1136/heartjnl-2016-309541DOI Listing
December 2016

Meta-analysis of genome-wide association studies of HDL cholesterol response to statins.

J Med Genet 2016 12 1;53(12):835-845. Epub 2016 Sep 1.

Department of Atherosclerosis Research, Children's Hospital Oakland Research Institute, Oakland, California, USA.

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http://dx.doi.org/10.1136/jmedgenet-2016-103966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309131PMC
December 2016

Predicting Prognosis in Acute Coronary Syndromes: Makeover Time for TIMI and GRACE?

Can J Cardiol 2016 11 21;32(11):1290-1293. Epub 2016 Feb 21.

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Québec, Canada.

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http://dx.doi.org/10.1016/j.cjca.2016.02.053DOI Listing
November 2016

Reducing exposure to cardiovascular risk factors: the legacy of prevention.

J Thorac Dis 2016 Sep;8(9):2340-2343

Québec Heart and Lung Institute, Québec, Canada;; Cleveland Clinic Coordinating Center for Clinical Research (C5R), Ohio, USA.

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http://dx.doi.org/10.21037/jtd.2016.08.83DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059310PMC
September 2016

Circulating Lp-PLA2 is associated with high valvuloarterial impedance and low arterial compliance in patients with aortic valve bioprostheses.

Clin Chim Acta 2016 Apr 18;455:20-5. Epub 2016 Jan 18.

Laboratoire d'Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2016.01.014DOI Listing
April 2016

Resting heart rate as a predictor of aortic valve stenosis progression.

Int J Cardiol 2016 Feb 26;204:149-51. Epub 2015 Nov 26.

Montreal Heart Institute, Université de Montréal, Montreal, Canada; Department of Medicine, Université de Montréal, Montreal, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2015.11.166DOI Listing
February 2016

Calcium Signaling Pathway Genes RUNX2 and CACNA1C Are Associated With Calcific Aortic Valve Disease.

Circ Cardiovasc Genet 2015 Dec 9;8(6):812-22. Epub 2015 Nov 9.

From the Centre de recherche Institut universitaire de cardiologie et de pneumologie de Québec, Quebec, Canada (S.G.-O., M.L., J.T.-M., E.L.-C., N.G., P.M., P.P., Y.B.); Departments of Molecular Medicine (A.D., Y.B.), Surgery (P.M.), and Medicine (P.P.), Laval University, Quebec, Canada; Cardiology Department, AP-HP, Bichat Hospital, Paris, France (D.M.-Z.); INSERM U698, Paris, France (D.M.-Z.); Département de Génétique, Hôpital Bichat, 75018 Paris, France (C.B.); Centre de Recherche du CHUQ, Quebec, Canada (A.D.); Montreal Heart Institute, Department of Medicine (M.-P.D., J.-C.T.), Université de Montréal, Montreal, Canada (B.J.A.); Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA (S.C.B.); and Department of Genetics, Harvard Medical School, Boston, MA (J.G.S.).

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http://dx.doi.org/10.1161/CIRCGENETICS.115.001145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934886PMC
December 2015

What does the future hold for cholesteryl ester transfer protein inhibition?

Curr Opin Lipidol 2015 Dec;26(6):526-35

aCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de QuébecbDepartment of Medicine, Faculty of Medicine, Université Laval, Québec, CanadacDepartment of Vascular Medicine, Academic Medical Center, AmsterdamdDezima Pharma BV, Naarden, the Netherlands.

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http://pdfs.journals.lww.com/co-lipidology/2015/12000/What_d
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MOL.0000000000000248DOI Listing
December 2015

Oxidized Phospholipids, Lipoprotein(a), and Progression of Calcific Aortic Valve Stenosis.

J Am Coll Cardiol 2015 Sep;66(11):1236-1246

Division of Cardiovascular Diseases, Department of Medicine, University of California San Diego, La Jolla, California. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2015.07.020DOI Listing
September 2015

Autotaxin Derived From Lipoprotein(a) and Valve Interstitial Cells Promotes Inflammation and Mineralization of the Aortic Valve.

Circulation 2015 Aug 29;132(8):677-90. Epub 2015 Jul 29.

From Laboratoire d'Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery (R.B., A.M., M.J.N., M.-C.B., J.-L.L., M.-H.L., F.H., P.M.), Department of Medicine (A.D., P.P., B.J.A., A.M.), Department of Pathology (C.C., S.T., S.P.), and Department of Molecular Medicine (Y.B.), Laval University, Québec, Canada; and Department of Chemistry and Biochemistry, University of Windsor, Ontario, Canada (C.A.S., R.R., M.L.K.).

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http://circ.ahajournals.org/content/early/2015/07/29/CIRCULA
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http://circ.ahajournals.org/lookup/doi/10.1161/CIRCULATIONAH
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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.016757DOI Listing
August 2015

Impact of plasma Lp-PLA2 activity on the progression of aortic stenosis: the PROGRESSA study.

JACC Cardiovasc Imaging 2015 Jan 1;8(1):26-33. Epub 2014 Nov 1.

Institut Universitaire de Cardiologie et de Pneumologie de Québec/Québec Heart and Lung Institute, Laval University, Québec City, Québec, Canada. Electronic address:

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http://imaging.onlinejacc.org/data/Journals/JCMG/931902/0901
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http://linkinghub.elsevier.com/retrieve/pii/S1936878X1400858
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http://dx.doi.org/10.1016/j.jcmg.2014.09.016DOI Listing
January 2015

Impact of abdominal obesity and systemic hypertension on risk of coronary heart disease in men and women: the EPIC-Norfolk Population Study.

J Hypertens 2014 Nov;32(11):2224-30; discussion 2230

aCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec City bDepartment of Family Medicine and Emergency Medicine cDepartment of Medicine dDepartment of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada eDepartment of Cardiology, Academic Medical Center, Amsterdam, the Netherlands fMedical Research Council Epidemiology Unit gDepartment of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/HJH.0000000000000307DOI Listing
November 2014

PCSK9 levels in abdominally obese men: association with cardiometabolic risk profile and effects of a one-year lifestyle modification program.

Atherosclerosis 2014 Oct 26;236(2):321-6. Epub 2014 Jul 26.

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Canada; Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.

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http://dx.doi.org/10.1016/j.atherosclerosis.2014.07.010DOI Listing
October 2014

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.

Authors:
Iris Postmus Stella Trompet Harshal A Deshmukh Michael R Barnes Xiaohui Li Helen R Warren Daniel I Chasman Kaixin Zhou Benoit J Arsenault Louise A Donnelly Kerri L Wiggins Christy L Avery Paula Griffin QiPing Feng Kent D Taylor Guo Li Daniel S Evans Albert V Smith Catherine E de Keyser Andrew D Johnson Anton J M de Craen David J Stott Brendan M Buckley Ian Ford Rudi G J Westendorp P Eline Slagboom Naveed Sattar Patricia B Munroe Peter Sever Neil Poulter Alice Stanton Denis C Shields Eoin O'Brien Sue Shaw-Hawkins Y-D Ida Chen Deborah A Nickerson Joshua D Smith Marie Pierre Dubé S Matthijs Boekholdt G Kees Hovingh John J P Kastelein Paul M McKeigue John Betteridge Andrew Neil Paul N Durrington Alex Doney Fiona Carr Andrew Morris Mark I McCarthy Leif Groop Emma Ahlqvist Joshua C Bis Kenneth Rice Nicholas L Smith Thomas Lumley Eric A Whitsel Til Stürmer Eric Boerwinkle Julius S Ngwa Christopher J O'Donnell Ramachandran S Vasan Wei-Qi Wei Russell A Wilke Ching-Ti Liu Fangui Sun Xiuqing Guo Susan R Heckbert Wendy Post Nona Sotoodehnia Alice M Arnold Jeanette M Stafford Jingzhong Ding David M Herrington Stephen B Kritchevsky Gudny Eiriksdottir Leonore J Launer Tamara B Harris Audrey Y Chu Franco Giulianini Jean G MacFadyen Bryan J Barratt Fredrik Nyberg Bruno H Stricker André G Uitterlinden Albert Hofman Fernando Rivadeneira Valur Emilsson Oscar H Franco Paul M Ridker Vilmundur Gudnason Yongmei Liu Joshua C Denny Christie M Ballantyne Jerome I Rotter L Adrienne Cupples Bruce M Psaty Colin N A Palmer Jean-Claude Tardif Helen M Colhoun Graham Hitman Ronald M Krauss J Wouter Jukema Mark J Caulfield

Nat Commun 2014 Oct 28;5:5068. Epub 2014 Oct 28.

1] NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London EC1M 6BQ, UK [2] Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London EC1M6BQ, UK.

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http://dx.doi.org/10.1038/ncomms6068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220464PMC
October 2014

Lipoprotein(a) levels, genotype, and incident aortic valve stenosis: a prospective Mendelian randomization study and replication in a case-control cohort.

Circ Cardiovasc Genet 2014 Jun 5;7(3):304-10. Epub 2014 Apr 5.

From the Montreal Heart Institute Research Center, Montreal, Quebec, Canada (B.J.A., M.-P.D., É.R., J.-C.T.); Department of Medicine, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada (B.J.A., M.-P.D., É.R., J.-C.T.); Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands (S.M.B.); MRC Epidemiology Unit (N.J.W.) and Department of Public Health and Primary Care (K.-T.K., M.S.S.), University of Cambridge, Cambridge, United Kingdom; and Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Hinxton, United Kingdom (M.S.S.).

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http://dx.doi.org/10.1161/CIRCGENETICS.113.000400DOI Listing
June 2014

Evaluation of links between high-density lipoprotein genetics, functionality, and aortic valve stenosis risk in humans.

Arterioscler Thromb Vasc Biol 2014 Feb 12;34(2):457-62. Epub 2013 Dec 12.

From the Montreal Heart Institute, Montreal, Canada (B.J.A., M.-P.D., M.R.B., A.B.d.O.M., V.L., A.-E.K., D.R., É.R., J.-C.T.); Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Canada (B.J.A., M.-P.D., M.R.B., A.B.d.O.M., É.R., J.-C.T.); Beaulieu-Saucier Université de Montréal Pharmacogenomics Centre, Montreal, Canada (M.-P.D., J.-C.T.); Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Québec (S.G.-O., P.M., P.P., Y.B.) and Department of Molecular Medicine (Y.B.), Laval University, Québec, Canada; Cardiology Department, AP-HP, Bichat Hospital, Paris, France (D.M.-Z.); and INSERM U698, University Paris 7, Paris, France (D.M.-Z.).

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http://dx.doi.org/10.1161/ATVBAHA.113.302730DOI Listing
February 2014

Clinical and biological relevance of statin-mediated changes in HDL metabolism.

Curr Atheroscler Rep 2014 Jan;16(1):379

Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Y-2110, Pavillon Marguerite D'Youville, 2725 chemin Ste-Foy, Quebec, QC, G1V 4G5, Canada,

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http://dx.doi.org/10.1007/s11883-013-0379-8DOI Listing
January 2014

Appreciating the local and systemic effects of exercise training on vascular health.

Atherosclerosis 2013 Nov 3;231(1):15-7. Epub 2013 Sep 3.

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Canada; Department of Medicine, Faculty of Medicine, Université Laval, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2013.08.022DOI Listing
November 2013

Non-HDL cholesterol vs. apo B for risk of coronary heart disease in healthy individuals: the EPIC-Norfolk prospective population study.

Eur J Clin Invest 2013 Oct 17;43(10):1009-15. Epub 2013 Jul 17.

Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/eci.12129DOI Listing
October 2013

Levels and changes of HDL cholesterol and apolipoprotein A-I in relation to risk of cardiovascular events among statin-treated patients: a meta-analysis.

Circulation 2013 Oct 21;128(14):1504-12. Epub 2013 Aug 21.

Departments of Cardiology (S.M.B.) and Vascular Medicine (B.J.A., G.K.H., J.J.P.K.), Academic Medical Center, Amsterdam, The Netherlands; Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, MA (S.M., P.M.R.); Center of Preventive Medicine, Oslo University Hospital, Ulleval and University of Oslo, Norway (T.R.P.); State University of New York Health Science Center, Brooklyn, NY (J.C.L.); Rosalind Franklin University of Medicine and Science, North Chicago, IL (K.M.A.W.); Department of Neurology and Stroke Center, Bichat University Hospital, Paris, France (P.A.); Global Pharmaceuticals Pfizer, New York, NY (D.A.D.); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (A.M.T.); Department of Biochemistry and Lipid Clinic, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia (D.R.S.); NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia (A.K.); Medical Research Institute, University of Dundee, Dundee, United Kingdom (H.M.C.); Centre for Diabetes, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom (G.A.H.); Department of Medicine, Royal Free and University College Medical School, London, United Kingdom (D.J.B.); School of Biomedicine, University of Manchester, Manchester, United Kingdom (P.N.D.); Touro University, Mare Island, CA (M.B.C.); Department of Medicine, University of Texas Health Science Center, and VERDICT, South Texas Veterans Health Care System, San Antonio, TX (J.R.D.); and Weill Cornell Medical College, New York, NY (A.M.G.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807966PMC
October 2013

Mapping body fat distribution: a key step towards the identification of the vulnerable patient?

Ann Med 2012 Dec 12;44(8):758-72. Epub 2011 Dec 12.

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Canada.

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http://dx.doi.org/10.3109/07853890.2011.605387DOI Listing
December 2012

HDL cholesterol is not HDL--don't judge the book by its cover.

Nat Rev Cardiol 2012 Oct 4;9(10):557-8. Epub 2012 Sep 4.

Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Pavilion Marguerite-D'Youville, 4th Floor, 2725 chemin Sainte-Foy, Québec, QC G1V 4G5, Canada.

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http://dx.doi.org/10.1038/nrcardio.2012.127DOI Listing
October 2012

Regression of atherosclerosis.

Curr Cardiol Rep 2012 Aug;14(4):443-9

Montreal Heart Institute, Université de Montréal, 5000 Belanger Street, Montreal, Québec, Canada.

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http://dx.doi.org/10.1007/s11886-012-0285-7DOI Listing
August 2012

An update on the clinical development of dalcetrapib (RO4607381), a cholesteryl ester transfer protein modulator that increases HDL cholesterol levels.

Future Cardiol 2012 Jul;8(4):513-31

Atherosclerosis Research Group, Montreal Heart Institute, 5000 Belanger St., Montreal, Quebec, Canada.

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https://www.futuremedicine.com/doi/10.2217/fca.12.25
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July 2012

Insulin resistance, low cardiorespiratory fitness, and increased exercise blood pressure: contribution of abdominal obesity.

Hypertension 2011 Dec 24;58(6):1036-42. Epub 2011 Oct 24.

Division of Kinesiology, Department of Social and Preventive Medicine, Université Laval, Québec, Québec, Canada.

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.111.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.180349DOI Listing
December 2011

Contributions of cardiorespiratory fitness and visceral adiposity to six-year changes in cardiometabolic risk markers in apparently healthy men and women.

J Clin Endocrinol Metab 2011 May 16;96(5):1462-8. Epub 2011 Feb 16.

Department of Family and Emergency Medicine, Faculty of Medicine, Université Laval, Québec, Canada G1V 0A6.

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http://dx.doi.org/10.1210/jc.2010-2432DOI Listing
May 2011

Varespladib: targeting the inflammatory face of atherosclerosis.

Eur Heart J 2011 Apr 25;32(8):923-6. Epub 2010 Nov 25.

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April 2011

Lipid parameters for measuring risk of cardiovascular disease.

Nat Rev Cardiol 2011 Apr 1;8(4):197-206. Epub 2011 Feb 1.

Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://www.nature.com/articles/nrcardio.2010.223
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April 2011

Physical activity, metabolic syndrome, and coronary risk: the EPIC-Norfolk prospective population study.

Eur J Cardiovasc Prev Rehabil 2011 Apr 28;18(2):209-17. Epub 2011 Jan 28.

Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.

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http://journals.sagepub.com/doi/10.1177/1741826710389397
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April 2011

Predictors of new-onset diabetes in patients treated with atorvastatin: results from 3 large randomized clinical trials.

J Am Coll Cardiol 2011 Apr;57(14):1535-45

Division of Cardiology, San Francisco General Hospital, and University of California at San Francisco, San Francisco, California 94114, USA.

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April 2011

Lipid assessment, metabolic syndrome and coronary heart disease risk.

Eur J Clin Invest 2010 Dec;40(12):1081-93

Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands.

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December 2010

Physical activity, the Framingham risk score and risk of coronary heart disease in men and women of the EPIC-Norfolk study.

Atherosclerosis 2010 Mar 31;209(1):261-5. Epub 2009 Aug 31.

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Canada.

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http://dx.doi.org/10.1016/j.atherosclerosis.2009.08.048DOI Listing
March 2010

HDL particle size and the risk of coronary heart disease in apparently healthy men and women: the EPIC-Norfolk prospective population study.

Atherosclerosis 2009 Sep 12;206(1):276-81. Epub 2009 Feb 12.

Hôpital Laval Research Centre, Pavilion Marguerite-D'Youville, 2725 chemin Sainte-Foy, Québec, Canada.

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http://dx.doi.org/10.1016/j.atherosclerosis.2009.01.044DOI Listing
September 2009

The quest for the optimal assessment of global cardiovascular risk: are traditional risk factors and metabolic syndrome partners in crime?

Cardiology 2009 30;113(1):35-49. Epub 2008 Oct 30.

Department of Anatomy and Physiology, Université Laval, Québec, Qué., Canada.

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July 2009

Low cardiorespiratory fitness levels and elevated blood pressure: what is the contribution of visceral adiposity?

Hypertension 2009 Jul 26;54(1):91-7. Epub 2009 May 26.

Department of Family and Emergency Medicine, Université Laval, Québec, Canada.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.109.131656DOI Listing
July 2009

Body composition, cardiorespiratory fitness, and low-grade inflammation in middle-aged men and women.

Am J Cardiol 2009 Jul 3;104(2):240-6. Epub 2009 Jun 3.

Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Québec, Québec, Canada.

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http://dx.doi.org/10.1016/j.amjcard.2009.03.027DOI Listing
July 2009

The concept of cardiometabolic risk: Bridging the fields of diabetology and cardiology.

Ann Med 2008 ;40(7):514-23

Hôpital Laval Research Centre, Québec, Canada.

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http://dx.doi.org/10.1080/07853890802004959DOI Listing
January 2009

Cholesterol levels in small LDL particles predict the risk of coronary heart disease in the EPIC-Norfolk prospective population study.

Eur Heart J 2007 Nov 17;28(22):2770-7. Epub 2007 Oct 17.

Department of Cardiology, Québec Heart Institute, Hôpital Laval Research Centre, Pavilion Marguerite-D'Youville, 4th Floor, 2725, chemin Sainte-Foy, Québec, QC, Canada G1V 4G5.

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November 2007