Benoit I Giasson

Benoit I Giasson

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Benoit I Giasson

Benoit I Giasson

Publications by authors named "Benoit I Giasson"

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Correction to: Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models.

Acta Neuropathol 2019 Oct;138(4):675

Center of Clinical Research, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens (BRFAA), 4 Soranou Efesiou Street, 11527, Athens, Greece.

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http://dx.doi.org/10.1007/s00401-019-02068-yDOI Listing
October 2019

Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models.

Acta Neuropathol 2019 Sep 22;138(3):415-441. Epub 2019 Apr 22.

Center of Clinical Research, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens (BRFAA), 4 Soranou Efesiou Street, 11527, Athens, Greece.

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http://dx.doi.org/10.1007/s00401-019-02014-yDOI Listing
September 2019

Exploring the Peripheral Initiation of Parkinson's Disease in Animal Models.

Neuron 2019 08;103(4):547-549

Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL 32610, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.07.031DOI Listing
August 2019

An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes.

J Exp Med 2019 Aug 29. Epub 2019 Aug 29.

McKnight Brain Institute, Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience and Neurology, College of Medicine, University of Florida, Gainesville, FL

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http://dx.doi.org/10.1084/jem.20190430DOI Listing
August 2019

MAPT mutations, tauopathy, and mechanisms of neurodegeneration.

Lab Invest 2019 Jul 11;99(7):912-928. Epub 2019 Feb 11.

Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.

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http://dx.doi.org/10.1038/s41374-019-0197-xDOI Listing
July 2019

α-Synuclein and astrocytes: tracing the pathways from homeostasis to neurodegeneration in Lewy body disease.

Acta Neuropathol 2019 Jul 23;138(1):1-21. Epub 2019 Feb 23.

Department of Neuroscience, Center for Translational Research in Neurodegenerative Diseases and McKnight Brain Institute, University of Florida, Gainesville, FL, 32610, USA.

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http://dx.doi.org/10.1007/s00401-019-01977-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571045PMC
July 2019

Designing antibodies against LRRK2-targeted tau epitopes.

PLoS One 2018 27;13(9):e0204367. Epub 2018 Sep 27.

Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204367PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160062PMC
March 2019

Phosphorylation of serine 305 in tau inhibits aggregation.

Neurosci Lett 2019 01 10;692:187-192. Epub 2018 Nov 10.

Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043940183077
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http://dx.doi.org/10.1016/j.neulet.2018.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351168PMC
January 2019

Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease.

Acta Neuropathol 2018 12 23;136(6):919-938. Epub 2018 Aug 23.

Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, Gainesville, FL, 32610-0244, USA.

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http://link.springer.com/10.1007/s00401-018-1895-y
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http://dx.doi.org/10.1007/s00401-018-1895-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411038PMC
December 2018

Motor neuron loss and neuroinflammation in a model of α-synuclein-induced neurodegeneration.

Neurobiol Dis 2018 12 6;120:98-106. Epub 2018 Sep 6.

Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2018.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190709PMC
December 2018

Partial loss of ATP13A2 causes selective gliosis independent of robust lipofuscinosis.

Mol Cell Neurosci 2018 10 1;92:17-26. Epub 2018 Jun 1.

Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32610, USA; Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2018.05.009DOI Listing
October 2018

Localized Induction of Wild-Type and Mutant Alpha-Synuclein Aggregation Reveals Propagation along Neuroanatomical Tracts.

J Virol 2018 09 29;92(18). Epub 2018 Aug 29.

Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.

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http://dx.doi.org/10.1128/JVI.00586-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146706PMC
September 2018

Novel monoclonal antibodies targeting the microtubule-binding domain of human tau.

PLoS One 2018 2;13(4):e0195211. Epub 2018 Apr 2.

Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195211PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880389PMC
July 2018

Adsorption and decontamination of α-synuclein from medically and environmentally-relevant surfaces.

Colloids Surf B Biointerfaces 2018 Jun 9;166:98-107. Epub 2018 Mar 9.

Department of Civil Engineering, University of Nebraska-Lincoln, United States; Center for Nanohybrid Functional Materials, University of Nebraska-Lincoln, United States. Electronic address:

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http://dx.doi.org/10.1016/j.colsurfb.2018.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911191PMC
June 2018

Locomotor differences in mice expressing wild-type human α-synuclein.

Neurobiol Aging 2018 05 6;65:140-148. Epub 2018 Feb 6.

Department of Neuroscience, and CTRND, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.01.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871592PMC
May 2018

Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology.

Mol Neurodegener 2018 05 18;13(1):23. Epub 2018 May 18.

Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, 1275 Center Drive, BMS Building J-491, PO Box, Gainesville, FL, 32610-0244, USA.

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http://dx.doi.org/10.1186/s13024-018-0253-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960184PMC
May 2018

Prion-like Spreading in Tauopathies.

Biol Psychiatry 2018 02 13;83(4):337-346. Epub 2017 Apr 13.

Department of Neuroscience, University of Florida, Gainesville, Florida; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, Florida; McKnight Brain Institute, University of Florida, Gainesville, Florida. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2017.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640465PMC
February 2018

Prion-like transmission of α-synuclein pathology in the context of an NFL null background.

Neurosci Lett 2017 Nov 28;661:114-120. Epub 2017 Sep 28.

Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL 32610, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2017.09.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813496PMC
November 2017

The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome.

PLoS One 2017 6;12(9):e0184262. Epub 2017 Sep 6.

Center for Translational Research in Neurodegenerative Disease, Department of Neurology, College of Medicine, University of Florida, Gainesville, FL, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184262PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587320PMC
October 2017

A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies.

PLoS One 2017 14;12(9):e0184731. Epub 2017 Sep 14.

Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, College of Medicine University of Florida, Gainesville, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184731PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599040PMC
October 2017

Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau.

Acta Neuropathol Commun 2017 07 31;5(1):58. Epub 2017 Jul 31.

Department of Neuroscience, College of Medicine University of Florida, Gainesville, FL, 32610, USA.

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http://dx.doi.org/10.1186/s40478-017-0458-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537986PMC
July 2017

Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity.

Mol Neurodegener 2017 05 29;12(1):40. Epub 2017 May 29.

Department of Neuroscience, University of Florida, 1275 Center Drive, PO Box 100159, Gainesville, FL, 32610, USA.

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http://dx.doi.org/10.1186/s13024-017-0182-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447308PMC
May 2017

Proteolysis of α-synuclein fibrils in the lysosomal pathway limits induction of inclusion pathology.

J Neurochem 2017 02 19;140(4):662-678. Epub 2016 Aug 19.

Department of Neuroscience, College of Medicine University of Florida, Gainesville, Florida, USA.

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http://dx.doi.org/10.1111/jnc.13743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452425PMC
February 2017

Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice.

Mol Neurodegener 2017 01 3;12(1). Epub 2017 Jan 3.

Department of Neuroscience, University of Florida, Gainesville, Florida, 32610, USA.

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http://dx.doi.org/10.1186/s13024-016-0142-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210310PMC
January 2017

Novel antibodies to phosphorylated α-synuclein serine 129 and NFL serine 473 demonstrate the close molecular homology of these epitopes.

Acta Neuropathol Commun 2016 08 8;4(1):80. Epub 2016 Aug 8.

Department of Neuroscience, College of Medicine University of Florida, Gainesville, FL, 32610, USA.

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http://dx.doi.org/10.1186/s40478-016-0357-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977832PMC
August 2016

Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.

Acta Neuropathol 2016 Jan 7;131(1):49-73. Epub 2015 Oct 7.

Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, McKinght Brain Institute, University of Florida, 1275 Center Drive, PO Box 100159, Gainesville, FL, 32610-0159, USA.

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http://dx.doi.org/10.1007/s00401-015-1485-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698305PMC
January 2016

Propagation of Aβ, tau and α-synuclein pathology between experimental models and human reality: prions, propagons and propaganda.

Acta Neuropathol 2016 Jan;131(1):1-3

Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149, Münster, Germany.

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http://dx.doi.org/10.1007/s00401-015-1517-xDOI Listing
January 2016

Physiologically relevant factors influence tau phosphorylation by leucine-rich repeat kinase 2.

J Neurosci Res 2015 Oct 30;93(10):1567-80. Epub 2015 Jun 30.

Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida.

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http://dx.doi.org/10.1002/jnr.23614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869353PMC
October 2015

Inefficient induction and spread of seeded tau pathology in P301L mouse model of tauopathy suggests inherent physiological barriers to transmission.

Acta Neuropathol 2015 08 16;130(2):303-5. Epub 2015 May 16.

Department of Neuroscience, Center for Translational Research in Neurodegenerative Diseases, University of Florida, Gainesville, FL, 32610, USA,

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http://dx.doi.org/10.1007/s00401-015-1444-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652651PMC
August 2015

Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice.

Mol Neurodegener 2015 Jul 30;10:32. Epub 2015 Jul 30.

Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, 1275 Center Drive, Room BMS J-483, PO Box 100159, Gainesville, FL, 32610, USA.

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http://dx.doi.org/10.1186/s13024-015-0029-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520273PMC
July 2015

The A53E α-synuclein pathological mutation demonstrates reduced aggregation propensity in vitro and in cell culture.

Neurosci Lett 2015 Jun 17;597:43-8. Epub 2015 Apr 17.

Center for Translational Research in Neurodegenerative Disease and Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL 32610, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2015.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476064PMC
June 2015

Divergent effects of the H50Q and G51D SNCA mutations on the aggregation of α-synuclein.

J Neurochem 2014 Dec 21;131(6):859-67. Epub 2014 Jul 21.

Center for Translational Research in Neurodegenerative Disease and Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida, USA.

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http://dx.doi.org/10.1111/jnc.12806DOI Listing
December 2014

Brain injection of α-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker.

J Neurosci 2014 Sep;34(37):12368-78

Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, College of Medicine University of Florida, Gainesville, Florida 32610, and

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http://dx.doi.org/10.1523/JNEUROSCI.2102-14.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615494PMC
September 2014

A cellular system that degrades misfolded proteins and protects against neurodegeneration.

Mol Cell 2014 Jul 29;55(1):15-30. Epub 2014 May 29.

Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.04.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445634PMC
July 2014

Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.

Proc Natl Acad Sci U S A 2014 Jul 7;111(29):10732-7. Epub 2014 Jul 7.

Department of Neuroscience,Center for Translational Research in Neurodegenerative Disease, andMcKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL 32610

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http://dx.doi.org/10.1073/pnas.1321785111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115570PMC
July 2014

Does a prion-like mechanism play a major role in the apparent spread of α-synuclein pathology?

Alzheimers Res Ther 2012 17;4(6):48. Epub 2012 Dec 17.

Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, University of Florida, 1275 Center Drive, BMS Building J-483, P.O. Box 100159, Gainesville, FL 32610-0244, USA.

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http://dx.doi.org/10.1186/alzrt151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580457PMC
June 2014

Transgenic mice expressing S129 phosphorylation mutations in α-synuclein.

Neurosci Lett 2014 Mar 30;563:96-100. Epub 2014 Jan 30.

Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA; Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2014.01.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059511PMC
March 2014

LRRK2 phosphorylates novel tau epitopes and promotes tauopathy.

Acta Neuropathol 2013 Dec 11;126(6):809-27. Epub 2013 Oct 11.

Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, 32610, USA.

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http://dx.doi.org/10.1007/s00401-013-1188-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830748PMC
December 2013

Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions.

Brain Res 2013 Aug 15;1524:62-73. Epub 2013 Jun 15.

Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1016/j.brainres.2013.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914001PMC
August 2013

Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein.

Acta Neuropathol Commun 2013 Jul 17;1:38. Epub 2013 Jul 17.

Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, BMS Building J-483, University of Florida College of Medicine, 1275 Center Drive, PO Box 100159, Gainesville, FL 32610, USA.

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http://actaneurocomms.biomedcentral.com/articles/10.1186/205
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http://dx.doi.org/10.1186/2051-5960-1-38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893388PMC
July 2013

Thinking laterally about neurodegenerative proteinopathies.

J Clin Invest 2013 May 1;123(5):1847-55. Epub 2013 May 1.

Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, Florida 32610, USA.

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http://dx.doi.org/10.1172/JCI66029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635732PMC
May 2013

Conformational templating of α-synuclein aggregates in neuronal-glial cultures.

Mol Neurodegener 2013 May 28;8:17. Epub 2013 May 28.

Department of Neuroscience, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1186/1750-1326-8-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671973PMC
May 2013

Characterization of cellular protective effects of ATP13A2/PARK9 expression and alterations resulting from pathogenic mutants.

J Neurosci Res 2012 Dec 30;90(12):2306-16. Epub 2012 Jul 30.

Department of Cellular and Molecular Physiology, Stanford University, Stanford, California, USA.

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http://doi.wiley.com/10.1002/jnr.23112
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http://dx.doi.org/10.1002/jnr.23112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484830PMC
December 2012

Studies of protein aggregation in A53T α-synuclein transgenic, Tg2576 transgenic, and P246L presenilin-1 knock-in cross bred mice.

Neurosci Lett 2012 Jan 13;507(2):137-42. Epub 2011 Dec 13.

Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104-6084, USA.

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http://dx.doi.org/10.1016/j.neulet.2011.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261842PMC
January 2012

α-Synuclein, leucine-rich repeat kinase-2, and manganese in the pathogenesis of Parkinson disease.

Neurotoxicology 2011 Oct 14;32(5):622-9. Epub 2011 Jan 14.

Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6084, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0161813X110000
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http://dx.doi.org/10.1016/j.neuro.2011.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134594PMC
October 2011

E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment.

J Biol Chem 2011 Oct 16;286(40):35104-18. Epub 2011 Aug 16.

Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.247965
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http://dx.doi.org/10.1074/jbc.M111.247965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186371PMC
October 2011

Induction of intracellular tau aggregation is promoted by α-synuclein seeds and provides novel insights into the hyperphosphorylation of tau.

J Neurosci 2011 May;31(21):7604-18

Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6084, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.0297-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122484PMC
May 2011

Characterization of kinases involved in the phosphorylation of aggregated α-synuclein.

J Neurosci Res 2011 Feb 8;89(2):231-47. Epub 2010 Dec 8.

Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/jnr.22537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484797PMC
February 2011

L10p and P158DEL DJ-1 mutations cause protein instability, aggregation, and dimerization impairments.

J Neurosci Res 2010 Nov;88(14):3111-24

Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6084, USA.

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http://dx.doi.org/10.1002/jnr.22477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943528PMC
November 2010

Glucocerebrosidase is present in α-synuclein inclusions in Lewy body disorders.

Acta Neuropathol 2010 Nov 14;120(5):641-9. Epub 2010 Sep 14.

Section on Molecular Neurogenetics, Medical Genetics Branch, NHGRI, National Institutes of Health, Bethesda, MD 20892-3708, USA.

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http://link.springer.com/10.1007/s00401-010-0741-7
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http://dx.doi.org/10.1007/s00401-010-0741-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352317PMC
November 2010

The G2019S pathogenic mutation disrupts sensitivity of leucine-rich repeat kinase 2 to manganese kinase inhibition.

J Neurochem 2010 Oct 19;115(1):36-46. Epub 2010 Aug 19.

Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6084, USA.

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http://doi.wiley.com/10.1111/j.1471-4159.2010.06894.x
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http://dx.doi.org/10.1111/j.1471-4159.2010.06894.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963190PMC
October 2010

DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function.

Proc Natl Acad Sci U S A 2010 May 10;107(21):9747-52. Epub 2010 May 10.

Department of Biology, Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906840PMC
May 2010

Identification and characterization of a novel endogenous murine parkin mutation.

J Neurochem 2010 Apr 20;113(2):402-17. Epub 2010 Jan 20.

Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6084, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06605.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908247PMC
April 2010

DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity.

Hum Mol Genet 2010 Apr 20;19(8):1425-37. Epub 2010 Jan 20.

Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6084, USA.

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http://dx.doi.org/10.1093/hmg/ddq017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846158PMC
April 2010

A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formation.

J Neurochem 2010 Apr 2;113(2):374-88. Epub 2010 Feb 2.

Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104-6084, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06592.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907888PMC
April 2010

Residue Glu83 plays a major role in negatively regulating alpha-synuclein amyloid formation.

Biochem Biophys Res Commun 2010 Jan 21;391(3):1415-20. Epub 2009 Dec 21.

Department of Pharmacology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, 125 John Morgan Building, Philadelphia, PA 19104-6084, USA.

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http://dx.doi.org/10.1016/j.bbrc.2009.12.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812690PMC
January 2010

Characterization of hydrophobic residue requirements for alpha-synuclein fibrillization.

Biochemistry 2009 Oct;48(40):9427-36

Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://pubs.acs.org/doi/abs/10.1021/bi900539p
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758333PMC
October 2009

Molecular mechanisms of alpha-synuclein neurodegeneration.

Biochim Biophys Acta 2009 Jul 9;1792(7):616-24. Epub 2008 Oct 9.

Department of Pharmacology, University of Pennsylvania School of Medicine, 125 John Morgan Building, Philadelphia, PA 19104-6084, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756732PMC
July 2009

Leucine-rich repeat kinase 2 expression leads to aggresome formation that is not associated with alpha-synuclein inclusions.

J Neuropathol Exp Neurol 2009 Jul;68(7):785-96

Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6084, USA.

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http://dx.doi.org/10.1097/NEN.0b013e3181aaf4fdDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722758PMC
July 2009

Clinical and pathological characteristics of patients with leucine-rich repeat kinase-2 mutations.

Mov Disord 2009 Jan;24(1):32-9

Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6084, USA.

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http://dx.doi.org/10.1002/mds.22096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634827PMC
January 2009

Identification of compounds that inhibit the kinase activity of leucine-rich repeat kinase 2.

Biochem Biophys Res Commun 2009 Jan 21;378(3):473-7. Epub 2008 Nov 21.

Department of Pharmacology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, 125 John Morgan Building, Philadelphia, PA 19104-6084, USA.

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http://dx.doi.org/10.1016/j.bbrc.2008.11.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633649PMC
January 2009

The E163K DJ-1 mutant shows specific antioxidant deficiency.

Brain Res 2008 Nov 16;1239:1-11. Epub 2008 Sep 16.

Department of Pharmacology, University of Pennsylvania School of Medicine, 125 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104-6084, USA.

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http://dx.doi.org/10.1016/j.brainres.2008.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783860PMC
November 2008

Characterization of antibodies that selectively detect alpha-synuclein in pathological inclusions.

Acta Neuropathol 2008 Jul 15;116(1):37-46. Epub 2008 Apr 15.

Department of Pharmacology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, 123 John Morgan Building, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s00401-008-0375-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664556PMC
July 2008

Alpha-synuclein activates stress signaling protein kinases in THP-1 cells and microglia.

Neurobiol Aging 2008 May 12;29(5):739-52. Epub 2006 Dec 12.

Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada.

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May 2008

Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.

J Neuropathol Exp Neurol 2008 May;67(5):402-16

Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6084, USA.

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http://dx.doi.org/10.1097/NEN.0b013e31816fc995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930078PMC
May 2008

Mutations in LRRK2 as a cause of Parkinson's disease.

Neurosignals 2008 5;16(1):99-105. Epub 2007 Dec 5.

Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104-6084, USA.

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April 2008

Role of mitochondrial dysfunction in Parkinson's disease: Implications for treatment.

Drugs Aging 2007 ;24(2):95-105

Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6084, USA.

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http://dx.doi.org/10.2165/00002512-200724020-00002DOI Listing
May 2007

Pesticide exposure exacerbates alpha-synucleinopathy in an A53T transgenic mouse model.

Am J Pathol 2007 Feb;170(2):658-66

Center for Neurodegenerative Disease Research, Institute on Aging, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3600 Spruce St., Maloney 3, HUP, Philadelphia, PA 19104-4283, USA.

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http://dx.doi.org/10.2353/ajpath.2007.060359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851868PMC
February 2007

Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells.

FASEB J 2006 Oct;20(12):2000-8

Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada.

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http://www.fasebj.org/doi/10.1096/fj.06-6183com
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October 2006

Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates.

J Neurosci 2006 Sep;26(39):10068-78

The Joseph Stokes Jr. Research Institute, The Children's Hospital of Philadelphia and The University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.0896-06.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6674486PMC
September 2006

Biochemical and pathological characterization of Lrrk2.

Ann Neurol 2006 Feb;59(2):315-22

Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6084, USA.

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http://dx.doi.org/10.1002/ana.20791DOI Listing
February 2006

Snaring the function of alpha-synuclein.

Cell 2005 Nov;123(3):359-61

Department of Biology and Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1016/j.cell.2005.10.017DOI Listing
November 2005

Role of oxidative damage in protein aggregation associated with Parkinson's disease and related disorders.

Antioxid Redox Signal 2005 May-Jun;7(5-6):672-84

Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1089/ars.2005.7.672DOI Listing
September 2005

Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations.

J Biol Chem 2005 Jun 6;280(22):21212-9. Epub 2005 Apr 6.

Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Institute on Aging, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M412621200DOI Listing
June 2005

A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease.

J Biol Chem 2005 Jun 19;280(24):22670-8. Epub 2005 Apr 19.

Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 75390, USA.

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http://dx.doi.org/10.1074/jbc.M501508200DOI Listing
June 2005

DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein.

J Neurochem 2005 Jun;93(6):1524-32

Department of Biology and Laboratory of Medicine of University of Pennsylvania, Philadelphia 19104-6084, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2005.03145.xDOI Listing
June 2005

Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein.

Biochemistry 2005 May;44(21):7818-29

Department of Neurology, University of Pennsylvania and The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1021/bi047846qDOI Listing
May 2005

The E46K mutation in alpha-synuclein increases amyloid fibril formation.

J Biol Chem 2005 Mar 4;280(9):7800-7. Epub 2005 Jan 4.

Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M411638200
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March 2005

Mouse model of multiple system atrophy alpha-synuclein expression in oligodendrocytes causes glial and neuronal degeneration.

Neuron 2005 Mar;45(6):847-59

Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1016/j.neuron.2005.01.032DOI Listing
March 2005

Mitochondrial injury: a hot spot for parkinsonism and Parkinson's disease?

Authors:
Benoit I Giasson

Sci Aging Knowledge Environ 2004 Dec 1;2004(48):pe42. Epub 2004 Dec 1.

Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/sageke.2004.48.pe42DOI Listing
December 2004