Dr Benoit Deprez, PhD MBA - Universite de Lille - professor

Dr Benoit Deprez

PhD MBA

Universite de Lille

professor

Lille | France

Main Specialties: Other

Additional Specialties: drug discovery

Dr Benoit Deprez, PhD MBA - Universite de Lille - professor

Dr Benoit Deprez

PhD MBA

Introduction

Primary Affiliation: Universite de Lille - Lille , France

Specialties:

Additional Specialties:

Publications

43Publications

1176Reads

-Profile Views

448PubMed Central Citations

Kinetic target-guided synthesis in drug discovery and chemical biology: a comprehensive facts and figures survey.

Future Med Chem 2016 15;8(4):381-404. Epub 2016 Feb 15.

Inserm, Institut Pasteur de Lille, U1177 Drugs & Molecules for Living Systems, Université de Lille, F-59000 Lille, France.

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http://dx.doi.org/10.4155/fmc-2015-0007DOI Listing
November 2016
13 Reads
3 Citations
4.000 Impact Factor

Characterization of monoclonal antibodies by a fast and easy liquid chromatography-mass spectrometry time-of-flight analysis on culture supernatant.

Anal Biochem 2015 Dec 22;491:52-4. Epub 2015 Aug 22.

INSERM U1177 "Drugs and Molecules for Living Systems", Université de Lille, and Institut Pasteur de Lille, 59000 Lille, France.

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http://dx.doi.org/10.1016/j.ab.2015.08.006DOI Listing
December 2015
19 Reads
1 Citation
2.220 Impact Factor

The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity.

Cell Metab 2015 Sep 30;22(3):418-26. Epub 2015 Jul 30.

Department of Human Biology and Human Movement Sciences, NUTRIM, School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht 6200 MD, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.07.002DOI Listing
September 2015
29 Reads
45 Citations
17.570 Impact Factor

Inhibition of aggrecanases as a therapeutic strategy in osteoarthritis.

Future Med Chem 2014 ;6(12):1399-412

INSERM U761 Biostructures & Drug Discovery unit University Lille Nord de France, Institut Pasteur de Lille, rue Laguesse, Lille, F-59000, France.

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http://dx.doi.org/10.4155/fmc.14.84DOI Listing
August 2015
15 Reads
4.000 Impact Factor

Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion.

Nat Med 2015 May 20;21(5):512-7. Epub 2015 Apr 20.

1] European Genomic Institute for Diabetes, Lille, France. [2] INSERM UMR 1190, Lille, France. [3] Centre Hospitalier Régional Universitaire, Lille, France. [4] Université de Lille, Lille, France.

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http://dx.doi.org/10.1038/nm.3828DOI Listing
May 2015
54 Reads
70 Citations
27.363 Impact Factor

Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.

Eur J Med Chem 2015 Jan 4;90:547-67. Epub 2014 Dec 4.

INSERM U761 Biostructures and Drug Discovery, Lille, France; Lille F-59000, France; Institut Pasteur de Lille, IFR 142, Lille F-59000, France; PRIM, Lille F-59000, France; CDithem Platform/IGM, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325277PMC
January 2015
47 Reads
4 Citations
3.450 Impact Factor

Identification of Small Inhibitory Molecules Targeting the Bfl-1 Anti-Apoptotic Protein That Alleviates Resistance to ABT-737.

J Biomol Screen 2014 Aug 8;19(7):1035-46. Epub 2014 May 8.

CDithem. Faculté de Pharmacie, Lille, France; www.CDithem.com INSERM U761, Biostructures and Drug Discovery, Université de Lille, Institut Pasteur de Lille, IFR 142, PRIM, Lille, France

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http://dx.doi.org/10.1177/1087057114534070DOI Listing
August 2014
36 Reads
2 Citations
2.423 Impact Factor

Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis.

Eur J Med Chem 2014 May 4;79:184-93. Epub 2014 Apr 4.

INSERM U761 Biostructures and Drug Discovery, Lille, France; Univ Lille Nord de France, Lille F-59000, France; Institut Pasteur de Lille, IFR 142, Lille F-59000, France; PRIM, Lille F-59000, France; CDithem Platform/IGM, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128174PMC
May 2014
31 Reads
6 Citations
3.450 Impact Factor

Unconventional surface plasmon resonance signals reveal quantitative inhibition of transcriptional repressor EthR by synthetic ligands.

Anal Biochem 2014 May 20;452:54-66. Epub 2014 Feb 20.

Institut Pasteur de Lille, F-59019 Lille, France; PRIM, F-59019 Lille, France; Center for Infection and Immunity of Lille, INSERM U1019-CNRS UMR 8204, University of Lille Nord de France, F-59000 Lille, France. Electronic address:

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http://dx.doi.org/10.1016/j.ab.2014.02.011DOI Listing
May 2014
27 Reads
4 Citations
2.220 Impact Factor

Structural and docking studies of potent ethionamide boosters.

Acta Crystallogr C 2013 Nov 24;69(Pt 11):1243-50. Epub 2013 Oct 24.

Department of Chemistry, Durham University, South Road, Durham DH1 3LE, England.

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http://dx.doi.org/10.1107/S0108270113028126DOI Listing
November 2013
15 Reads
3 Citations
0.330 Impact Factor

Aggrecanase-2 inhibitors based on the acylthiosemicarbazide zinc-binding group.

Eur J Med Chem 2013 Nov 30;69:244-61. Epub 2013 Aug 30.

INSERM U761, Biostructures and Drug Discovery, France; Faculté de Pharmacie, Univ Lille Nord de France, 3 rue du Pr Laguesse, Lille F-59006, France; Institut Pasteur de Lille, IFR 142, Lille F-59021, France; PRIM, Lille F-59006, France.

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http://dx.doi.org/10.1016/j.ejmech.2013.08.027DOI Listing
November 2013
20 Reads
1 Citation
3.450 Impact Factor

Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors.

J Med Chem 2012 Dec 5;55(24):10909-17. Epub 2012 Dec 5.

INSERM U761, Biostructures and Drug Discovery and Faculté de Pharmacie, Université Lille Nord de France, 3 rue du Pr Laguesse, Lille F-59000, France.

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http://dx.doi.org/10.1021/jm301506hDOI Listing
December 2012
25 Reads
7 Citations
5.450 Impact Factor

Setting Up a Bioluminescence Resonance Energy Transfer High throughput Screening Assay to Search for Protein/Protein Interaction Inhibitors in Mammalian Cells.

Front Endocrinol (Lausanne) 2012 11;3:100. Epub 2012 Sep 11.

Univ Lille Nord de France Lille, France.

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http://dx.doi.org/10.3389/fendo.2012.00100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438444PMC
September 2012
5 Reads
13 Citations

Rescue of nonsense mutations by amlexanox in human cells.

Orphanet J Rare Dis 2012 Aug 31;7:58. Epub 2012 Aug 31.

Université Lille Nord de France, IFR142, Lille, France.

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http://dx.doi.org/10.1186/1750-1172-7-58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562214PMC
August 2012
19 Reads
34 Citations
3.360 Impact Factor

Tuberculosis: the drug development pipeline at a glance.

Eur J Med Chem 2012 May 25;51:1-16. Epub 2012 Feb 25.

Univ Lille Nord de France, F-59000 Lille, France.

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http://dx.doi.org/10.1016/j.ejmech.2012.02.033DOI Listing
May 2012
16 Reads
24 Citations
3.450 Impact Factor

Drug-to-genome-to-drug, step 2: reversing selectivity in a series of antiplasmodial compounds.

J Med Chem 2012 Feb 24;55(3):1274-86. Epub 2012 Jan 24.

INSERM U761 Biostructures and Drug Discovery, Lille F-59006, France.

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http://dx.doi.org/10.1021/jm201422eDOI Listing
February 2012
8 Reads
3 Citations
5.450 Impact Factor

Application of Ullmann and Ullmann-Finkelstein reactions for the synthesis of N-aryl-N-(1H-pyrazol-3-yl) acetamide or N-(1-aryl-1H-pyrazol-3-yl) acetamide derivatives and pharmacological evaluation.

Eur J Med Chem 2011 Sep 30;46(9):3867-76. Epub 2011 May 30.

INSERM U761 Biostructures and Drug Discovery and Faculté de Pharmacie, Univ Lille Nord de France, 3 rue du Pr Laguesse, Lille F-59006, France.

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https://linkinghub.elsevier.com/retrieve/pii/S02235234110043
Publisher Site
http://dx.doi.org/10.1016/j.ejmech.2011.05.056DOI Listing
September 2011
14 Reads
3 Citations
3.450 Impact Factor

MALDI imaging techniques dedicated to drug-distribution studies.

Bioanalysis 2011 Jun;3(12):1399-406

ImaBiotech, 59655-Villeneuve d'Ascq, France.

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http://dx.doi.org/10.4155/bio.11.88DOI Listing
June 2011
9 Reads
3.003 Impact Factor

Drug to genome to drug: discovery of new antiplasmodial compounds.

J Med Chem 2011 May 19;54(9):3222-40. Epub 2011 Apr 19.

INSERM U761 Biostructures and Drug Discovery, Faculté de Pharmacie, Université Lille Nord de France, Institut Pasteur de Lille, and Pôle de Recherche Interdisciplinaire pour le Médicament , Lille F-59000, France.

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http://dx.doi.org/10.1021/jm1014617DOI Listing
May 2011
9 Reads
10 Citations
5.450 Impact Factor

New non-hydroxamic ADAMTS-5 inhibitors based on the 1,2,4-triazole-3-thiol scaffold.

Bioorg Med Chem Lett 2010 Nov 27;20(21):6213-6. Epub 2010 Aug 27.

INSERM U761 Biostructures and Drug Discovery, Univ. Lille Nord de France.

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http://dx.doi.org/10.1016/j.bmcl.2010.08.108DOI Listing
November 2010
8 Reads
4 Citations
2.420 Impact Factor

Hydroxamates: relationships between structure and plasma stability.

J Med Chem 2009 Nov;52(21):6790-802

INSERM U761 Biostructures and Drug Discovery, Univ Lille Nord de France, Lille F-59006, France.

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http://dx.doi.org/10.1021/jm900648xDOI Listing
November 2009
16 Reads
19 Citations
5.450 Impact Factor

Synthetic EthR inhibitors boost antituberculous activity of ethionamide.

Nat Med 2009 May 3;15(5):537-44. Epub 2009 May 3.

Institut National de la Santé et de la Recherche Médicale, Lille, France.

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http://dx.doi.org/10.1038/nm.1950DOI Listing
May 2009
38 Reads
34 Citations
27.363 Impact Factor

Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives.

Bioorg Med Chem Lett 2009 Jan 18;19(2):489-92. Epub 2008 Nov 18.

INSERM U761 Biostructures and Drug Discovery, 3 rue du Professeur Laguesse, Lille F-59006, France.

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http://dx.doi.org/10.1016/j.bmcl.2008.11.040DOI Listing
January 2009
6 Reads
1 Citation
2.420 Impact Factor

Synthesis of a 200-member library of squaric acid N-hydroxylamide amides.

Bioorg Med Chem Lett 2008 Sep 14;18(18):4968-71. Epub 2008 Aug 14.

INSERM U761, Biostructures and Drug Discovery, 3 rue du Professeur Laguesse, Nord, Lille F-59006, France.

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http://dx.doi.org/10.1016/j.bmcl.2008.08.025DOI Listing
September 2008
10 Reads
2 Citations
2.420 Impact Factor

Natural compounds: leads or ideas? Bioinspired molecules for drug discovery.

Chem Biol Drug Des 2008 Jul 11;72(1):3-15. Epub 2008 Jun 11.

INSERM U761, Biostructures and Drug Discovery, Lille, F-59006, France.

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http://dx.doi.org/10.1111/j.1747-0285.2008.00673.xDOI Listing
July 2008
9 Reads
9 Citations
2.485 Impact Factor

Alkylsquarates as key intermediates for the rapid preparation of original drug-inspired compounds.

Comb Chem High Throughput Screen 2008 May;11(4):294-303

INSERM U761 Biostructures and Drug Discovery, F-59006 Lille, France.

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May 2008
8 Reads
1 Citation
1.222 Impact Factor

In silico-in vitro screening of protein-protein interactions: towards the next generation of therapeutics.

Curr Pharm Biotechnol 2008 Apr;9(2):103-22

c-Dithem, Inserm Consortium for Discovery and Innovation in Therapy and Medicine, France.

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April 2008
16 Reads
11 Citations
2.511 Impact Factor

Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents.

J Med Chem 2007 Mar 28;50(6):1322-34. Epub 2007 Feb 28.

Inserm, U761, Biostructures and Drug Discovery, Lille F-59006 France.

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http://dx.doi.org/10.1021/jm061169bDOI Listing
March 2007
15 Reads
12 Citations
5.450 Impact Factor

PDE5 inhibitors: An original access to novel potent arylated analogues of tadalafil.

Bioorg Med Chem Lett 2007 Feb 27;17(3):789-92. Epub 2006 Oct 27.

Inserm U761 Biostructures and Drug Discovery Lille, F-59006, France.

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http://dx.doi.org/10.1016/j.bmcl.2006.10.069DOI Listing
February 2007
12 Reads
3 Citations
2.420 Impact Factor

A library of novel hydroxamic acids targeting the metallo-protease family: design, parallel synthesis and screening.

Bioorg Med Chem 2007 Jan 12;15(1):63-76. Epub 2006 Oct 12.

Inserm, U761, University of Lille 2, Faculty of Pharmacy, Institut Pasteur Lille, "Biostructures and Drug Discovery" 3 rue du Pr Laguesse F-59006 Lille cedex, France.

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http://dx.doi.org/10.1016/j.bmc.2006.10.010DOI Listing
January 2007
15 Reads
5 Citations
2.793 Impact Factor

Control of protein-protein interactions: structure-based discovery of low molecular weight inhibitors of the interactions between Pin1 WW domain and phosphopeptides.

J Med Chem 2005 Jul;48(15):4815-23

CNRS-University of Lille 2 UMR 8525, Institut Pasteur de Lille, Molecular Drug Discovery, 3 rue du Professeur Laguesse, 59000 Lille, France.

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http://dx.doi.org/10.1021/jm0500119DOI Listing
July 2005
15 Reads
11 Citations
5.450 Impact Factor

Facts, figures and trends in lead generation.

Curr Top Med Chem 2004 ;4(6):569-80

UMR CNRS 8525, Institut Pasteur, Université de Lille 2, Faculté des Sciences Pharmaceutiques et Biologiques, France.

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June 2004
6 Reads
3.402 Impact Factor

Versatile Acylation of N-Nucleophiles Using a New Polymer-Supported 1-Hydroxybenzotriazole Derivative.

J Org Chem 1997 Apr;62(8):2594-2603

CEREP, 1 rue du Pr. Calmette, 59 019 Lille Cédex, France and Chimie des Biomolécules, URA CNRS 1309, Institut Pasteur de Lille, Faculté de Pharmacie,1 rue du Pr. Calmette, 59 019 Lille Cédex, France.

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http://dx.doi.org/10.1021/jo961761gDOI Listing
April 1997
12 Reads
4.721 Impact Factor

Top co-authors

Florence Leroux
Florence Leroux

Université Lille Nord de France

19
Nicolas Willand
Nicolas Willand

Université Lille Nord de France

13
Julie Charton
Julie Charton

Universite de Lille II

12
Marion Flipo
Marion Flipo

Université Lille Nord de France

11
Alain R Baulard
Alain R Baulard

Université Catholique de Louvain

9
Benoit Deprez
Benoit Deprez

Universite de Lille

7
Vincent Villeret
Vincent Villeret

Université Lille Nord de France

7
Olivier Sperandio
Olivier Sperandio

University Paris Diderot

7
Julie Dumont
Julie Dumont

Cardiff University

7