Benjamin Tycko

Benjamin Tycko

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Benjamin Tycko

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Maternal prenatal stress phenotypes associate with fetal neurodevelopment and birth outcomes.

Authors:
Kate Walsh Clare A McCormack Rachel Webster Anita Pinto Seonjoo Lee Tianshu Feng H Sloan Krakovsky Sinclaire M O'Grady Benjamin Tycko Frances A Champagne Elizabeth A Werner Grace Liu Catherine Monk

Proc Natl Acad Sci U S A 2019 Nov 14;116(48):23996-24005. Epub 2019 Oct 14.

Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, NY 10032;

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http://dx.doi.org/10.1073/pnas.1905890116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883837PMC
November 2019

Sex differences in the associations of placental epigenetic aging with fetal growth.

Authors:
Fasil Tekola-Ayele Tsegaselassie Workalemahu Gezahegn Gorfu Deepika Shrestha Benjamin Tycko Ronald Wapner Cuilin Zhang Germaine M Buck Louis

Aging (Albany NY) 2019 Aug 8;11(15):5412-5432. Epub 2019 Aug 8.

Dean's Office, College of Health and Human Services, George Mason University, Fairfax, VA 22030, USA.

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http://dx.doi.org/10.18632/aging.102124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710059PMC
August 2019

Distinct epigenetic profiles in children with perinatally-acquired HIV on antiretroviral therapy.

Authors:
Stephanie Shiau Renate Strehlau Shuang Wang Avy Violari Catherine Do Faeezah Patel Afaaf Liberty Izabela Krupska Stephen M Arpadi Marc Foca Ashraf Coovadia Elaine J Abrams Benjamin Tycko Mary Beth Terry Louise Kuhn

Sci Rep 2019 Jul 19;9(1):10495. Epub 2019 Jul 19.

Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA.

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http://dx.doi.org/10.1038/s41598-019-46930-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642153PMC
July 2019

Inhibition of NF-κB-Dependent Signaling Enhances Sensitivity and Overcomes Resistance to BET Inhibition in Uveal Melanoma.

Authors:
Grazia Ambrosini Catherine Do Benjamin Tycko Ronald B Realubit Charles Karan Elgilda Musi Richard D Carvajal Vivian Chua Andrew E Aplin Gary K Schwartz

Cancer Res 2019 May 18;79(9):2415-2425. Epub 2019 Mar 18.

The Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-3177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643281PMC
May 2019

Breast cancer family history and allele-specific DNA methylation in the legacy girls study.

Authors:
Hui-Chen Wu Catherine Do Irene L Andrulis Esther M John Mary B Daly Saundra S Buys Wendy K Chung Julia A Knight Angela R Bradbury Theresa H M Keegan Lisa Schwartz Izabela Krupska Rachel L Miller Regina M Santella Benjamin Tycko Mary Beth Terry

Epigenetics 2018 2;13(3):240-250. Epub 2018 Apr 2.

a Herbert Irving Comprehensive Cancer Center , Columbia University Medical Center , New York , NY.

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http://dx.doi.org/10.1080/15592294.2018.1435243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997170PMC
February 2019

A pan-cancer analysis of driver gene mutations, DNA methylation and gene expressions reveals that chromatin remodeling is a major mechanism inducing global changes in cancer epigenomes.

Authors:
Ahrim Youn Kyung In Kim Raul Rabadan Benjamin Tycko Yufeng Shen Shuang Wang

BMC Med Genomics 2018 Nov 6;11(1):98. Epub 2018 Nov 6.

Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York, USA.

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https://bmcmedgenomics.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12920-018-0425-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218985PMC
November 2018

Epidemiology of estrogen and dementia in women with Down syndrome.

Authors:
Nicole Schupf Joseph H Lee Deborah Pang Warren B Zigman Benjamin Tycko Sharon Krinsky-McHale Wayne Silverman

Free Radic Biol Med 2018 01 31;114:62-68. Epub 2017 Aug 31.

Kennedy Krieger Institute and Johns Hopkins University School of Medicine, Baltimore, MD, United States.

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.08.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748249PMC
January 2018

Epigenetic Alterations Affecting Transcription Factors and Signaling Pathways in Stromal Cells of Endometriosis.

Authors:
Iveta Yotova Emily Hsu Catherine Do Aulona Gaba Matthias Sczabolcs Sabine Dekan Lukas Kenner Rene Wenzl Benjamin Tycko

PLoS One 2017 26;12(1):e0170859. Epub 2017 Jan 26.

Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0170859PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5268815PMC
August 2017

Candidate gene analysis for Alzheimer's disease in adults with Down syndrome.

Authors:
Joseph H Lee Annie J Lee Lam-Ha Dang Deborah Pang Sergey Kisselev Sharon J Krinsky-McHale Warren B Zigman José A Luchsinger Wayne Silverman Benjamin Tycko Lorraine N Clark Nicole Schupf

Neurobiol Aging 2017 08 3;56:150-158. Epub 2017 May 3.

Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, School of Public Health, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.04.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603247PMC
August 2017

The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain.

Authors:
Yan Jiang Yong-Hwee Eddie Loh Prashanth Rajarajan Teruyoshi Hirayama Will Liao Bibi S Kassim Behnam Javidfar Brigham J Hartley Lisa Kleofas Royce B Park Benoit Labonte Seok-Man Ho Sandhya Chandrasekaran Catherine Do Brianna R Ramirez Cyril J Peter Julia T C W Brian M Safaie Hirofumi Morishita Panos Roussos Eric J Nestler Anne Schaefer Benjamin Tycko Kristen J Brennand Takeshi Yagi Li Shen Schahram Akbarian

Nat Genet 2017 Aug 3;49(8):1239-1250. Epub 2017 Jul 3.

Friedman Brain Institute and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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http://www.nature.com/articles/ng.3906
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http://dx.doi.org/10.1038/ng.3906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560095PMC
August 2017

Genetic-epigenetic interactions in cis: a major focus in the post-GWAS era.

Authors:
Catherine Do Alyssa Shearer Masako Suzuki Mary Beth Terry Joel Gelernter John M Greally Benjamin Tycko

Genome Biol 2017 06 19;18(1):120. Epub 2017 Jun 19.

Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Taub Institute for Research on Alzheimer's disease and the Aging Brain, New York, NY, 10032, USA.

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http://dx.doi.org/10.1186/s13059-017-1250-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477265PMC
June 2017

NPTX2 and cognitive dysfunction in Alzheimer's Disease.

Authors:
Mei-Fang Xiao Desheng Xu Michael T Craig Kenneth A Pelkey Chun-Che Chien Yang Shi Juhong Zhang Susan Resnick Olga Pletnikova David Salmon James Brewer Steven Edland Jerzy Wegiel Benjamin Tycko Alena Savonenko Roger H Reeves Juan C Troncoso Chris J McBain Douglas Galasko Paul F Worley

Elife 2017 03 23;6. Epub 2017 Mar 23.

Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.

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http://dx.doi.org/10.7554/eLife.23798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404919PMC
March 2017

Trans-acting epigenetic effects of chromosomal aneuploidies: lessons from Down syndrome and mouse models.

Authors:
Catherine Do Zhuo Xing Y Eugene Yu Benjamin Tycko

Epigenomics 2017 02 2;9(2):189-207. Epub 2016 Dec 2.

Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.2217/epi-2016-0138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549717PMC
February 2017

Mouse-based genetic modeling and analysis of Down syndrome.

Authors:
Zhuo Xing Yichen Li Annie Pao Abigail S Bennett Benjamin Tycko William C Mobley Y Eugene Yu

Br Med Bull 2016 12 27;120(1):111-122. Epub 2016 Oct 27.

The Children's Guild Foundation Down Syndrome Research Program, Genetics Program and Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA

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https://academic.oup.com/bmb/article-lookup/doi/10.1093/bmb/
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http://dx.doi.org/10.1093/bmb/ldw040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146682PMC
December 2016

Distress During Pregnancy: Epigenetic Regulation of Placenta Glucocorticoid-Related Genes and Fetal Neurobehavior.

Authors:
Catherine Monk Tianshu Feng Seonjoo Lee Izabela Krupska Frances A Champagne Benjamin Tycko

Am J Psychiatry 2016 07 25;173(7):705-13. Epub 2016 Mar 25.

From the Department of Psychiatry, Columbia University Medical Center, New York; New York State Psychiatric Institute, New York; the Department of Obstetrics and Gynecology, Columbia University Medical Center, New York; the Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York; Institute for Cancer Genetics, Columbia University Medical Center, New York; the Department of Psychology, Columbia University, New York; and the Department of Pathology and Cell Biology, Columbia University Medical Center, New York.

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http://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2015.15
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http://dx.doi.org/10.1176/appi.ajp.2015.15091171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026410PMC
July 2016

Erratum to: Trans effects of chromosome aneuploidies on DNA methylation patterns in human Down syndrome and mouse models.

Authors:
Maite Mendioroz Catherine Do Xiaoling Jiang Chunhong Liu Huferesh K Darbary Charles F Lang John Lin Anna Thomas Sayeda Abu-Amero Philip Stanier Alexis Temkin Alexander Yale Meng-Min Liu Yang Li Martha Salas Kristi Kerkel George Capone Wayne Silverman Y Eugene Yu Gudrun Moore Jerzy Wegiel Benjamin Tycko

Genome Biol 2016 Jun 9;17(1):123. Epub 2016 Jun 9.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain and Institute for Cancer Genetics, Columbia University Medical Center, New York, NY, 10032, USA.

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http://dx.doi.org/10.1186/s13059-016-0949-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901436PMC
June 2016

Mechanisms and Disease Associations of Haplotype-Dependent Allele-Specific DNA Methylation.

Authors:
Catherine Do Charles F Lang John Lin Huferesh Darbary Izabela Krupska Aulona Gaba Lynn Petukhova Jean-Paul Vonsattel Mary P Gallagher Robin S Goland Raphael A Clynes Andrew Dwork John G Kral Catherine Monk Angela M Christiano Benjamin Tycko

Am J Hum Genet 2016 May;98(5):934-955

Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA; Departments of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.03.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863666PMC
May 2016

Trans effects of chromosome aneuploidies on DNA methylation patterns in human Down syndrome and mouse models.

Authors:
Maite Mendioroz Catherine Do Xiaoling Jiang Chunhong Liu Huferesh K Darbary Charles F Lang John Lin Anna Thomas Sayeda Abu-Amero Philip Stanier Alexis Temkin Alexander Yale Meng-Min Liu Yang Li Martha Salas Kristi Kerkel George Capone Wayne Silverman Y Eugene Yu Gudrun Moore Jerzy Wegiel Benjamin Tycko

Genome Biol 2015 Nov 25;16:263. Epub 2015 Nov 25.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain and Institute for Cancer Genetics, Columbia University Medical Center, New York, NY, 10032, USA.

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http://dx.doi.org/10.1186/s13059-015-0827-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659173PMC
November 2015

Candidate genes for Alzheimer's disease are associated with individual differences in plasma levels of beta amyloid peptides in adults with Down syndrome.

Authors:
Nicole Schupf Annie Lee Naeun Park Lam-Ha Dang Deborah Pang Alexander Yale David Kyung-Taek Oh Sharon J Krinsky-McHale Edmund C Jenkins José A Luchsinger Warren B Zigman Wayne Silverman Benjamin Tycko Sergey Kisselev Lorraine Clark Joseph H Lee

Neurobiol Aging 2015 Oct 19;36(10):2907.e1-10. Epub 2015 Jun 19.

The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA; G.H. Sergievsky Center, New York, NY, USA; Department of Epidemiology, Columbia University Medical Center, New York, NY, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562880PMC
October 2015

Down syndrome and Alzheimer's disease: Common pathways, common goals.

Authors:
Dean Hartley Thomas Blumenthal Maria Carrillo Gilbert DiPaolo Lucille Esralew Katheleen Gardiner Ann-Charlotte Granholm Khalid Iqbal Michael Krams Cynthia Lemere Ira Lott William Mobley Seth Ness Ralph Nixon Huntington Potter Roger Reeves Marwan Sabbagh Wayne Silverman Benjamin Tycko Michelle Whitten Thomas Wisniewski

Alzheimers Dement 2015 Jun 12;11(6):700-9. Epub 2014 Dec 12.

Department of Neurology, Pathology, and Psychiatry, New York University, Langone Medical Center, New York, NY, USA.

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http://dx.doi.org/10.1016/j.jalz.2014.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817997PMC
June 2015

Integrative epigenomic and genomic filtering for methylation markers in hepatocellular carcinomas.

Authors:
Jing Shen Clare LeFave Iryna Sirosh Abby B Siegel Benjamin Tycko Regina M Santella

BMC Med Genomics 2015 Jun 10;8:28. Epub 2015 Jun 10.

Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University Medical Center, New York, NY, 10032, USA.

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http://dx.doi.org/10.1186/s12920-015-0105-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460673PMC
June 2015

Stromal protein Ecm1 regulates ureteric bud patterning and branching.

Authors:
Suneeta S Paroly Fengwei Wang Lee Spraggon Joseph Merregaert Ekatherina Batourina Benjamin Tycko Kai M Schmidt-Ott Sean Grimmond Melissa Little Cathy Mendelsohn

PLoS One 2013 31;8(12):e84155. Epub 2013 Dec 31.

Department of Urology, Irving Cancer Research Center, Columbia University, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084155PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877229PMC
September 2014

PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors.

Authors:
Rieko Ohki Kozue Saito Yu Chen Tatsuya Kawase Nobuyoshi Hiraoka Raira Saigawa Maiko Minegishi Yukie Aita Goichi Yanai Hiroko Shimizu Shinichi Yachida Naoaki Sakata Ryuichiro Doi Tomoo Kosuge Kazuaki Shimada Benjamin Tycko Toshihiko Tsukada Yae Kanai Shoichiro Sumi Hideo Namiki Yoichi Taya Tatsuhiro Shibata Hitoshi Nakagama

Proc Natl Acad Sci U S A 2014 Jun 27;111(23):E2404-13. Epub 2014 May 27.

Divisions of Refractory Cancer Research.

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http://dx.doi.org/10.1073/pnas.1319962111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060701PMC
June 2014

Genetic epidemiology and nonsyndromic structural birth defects: from candidate genes to epigenetics.

Authors:
Charlotte A Hobbs Shimul Chowdhury Mario A Cleves Stephen Erickson Stewart L MacLeod Gary M Shaw Sanjay Shete John S Witte Benjamin Tycko

JAMA Pediatr 2014 Apr;168(4):371-7

Department of Pathology and Cell Biology, Institute for Cancer Genetics, Columbia University Medical Center, New York, New York.

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http://dx.doi.org/10.1001/jamapediatrics.2013.4858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981910PMC
April 2014

Intramuscular therapeutic vaccination targeting HPV16 induces T cell responses that localize in mucosal lesions.

Authors:
Leonel Maldonado Jessica E Teague Matthew P Morrow Iveta Jotova T C Wu Chenguang Wang Cindy Desmarais Jean D Boyer Benjamin Tycko Harlan S Robins Rachael A Clark Cornelia L Trimble

Sci Transl Med 2014 Jan;6(221):221ra13

Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.

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http://stm.sciencemag.org/cgi/doi/10.1126/scitranslmed.30073
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http://dx.doi.org/10.1126/scitranslmed.3007323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086631PMC
January 2014

PCDH10 promoter hypermethylation is frequent in most histologic subtypes of mature lymphoid malignancies and occurs early in lymphomagenesis.

Authors:
Gopeshwar Narayan Dongxu Xie Allen J Freddy Ganchimeg Ishdorj Catherine Do Prakash Satwani Hema Liyanage Lorraine Clark Sergey Kisselev Subhadra V Nandula Luigi Scotto Bachir Alobeid David Savage Benjamin Tycko Owen A O'Connor Govind Bhagat Vundavalli V Murty

Genes Chromosomes Cancer 2013 Nov 9;52(11):1030-41. Epub 2013 Aug 9.

Department of Pathology and Cell Biology, Columbia University Medical Center, New York Presbyterian Hospital, New York, NY.

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http://dx.doi.org/10.1002/gcc.22098DOI Listing
November 2013

Comparative anatomy of chromosomal domains with imprinted and non-imprinted allele-specific DNA methylation.

Authors:
Anupam Paliwal Alexis M Temkin Kristi Kerkel Alexander Yale Iveta Yotova Natalia Drost Simon Lax Chia-Ling Nhan-Chang Charles Powell Alain Borczuk Abraham Aviv Ronald Wapner Xiaowei Chen Peter L Nagy Nicholas Schork Catherine Do Ali Torkamani Benjamin Tycko

PLoS Genet 2013 Aug 29;9(8):e1003622. Epub 2013 Aug 29.

Institute for Cancer Genetics, Columbia University Medical Center, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757050PMC
August 2013

Creation and characterization of BAC-transgenic mice with physiological overexpression of epitope-tagged RCAN1 (DSCR1).

Authors:
Luzhou Xing Martha Salas Hong Zhang Julia Gittler Thomas Ludwig Chyuan-Sheng Lin Vundavalli V Murty Wayne Silverman Ottavio Arancio Benjamin Tycko

Mamm Genome 2013 Feb 25;24(1-2):30-43. Epub 2012 Oct 25.

Institute for Cancer Genetics, Columbia University Medical Center, Herbert Irving Cancer Research Building, New York, NY 10032, USA.

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http://dx.doi.org/10.1007/s00335-012-9436-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562396PMC
February 2013

Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma.

Authors:
Reena Shakya Tamas Gonda Michael Quante Martha Salas Samuel Kim Jenna Brooks Steffen Hirsch Justine Davies Angelica Cullo Kenneth Olive Timothy C Wang Matthias Szabolcs Benjamin Tycko Thomas Ludwig

Cancer Res 2013 Jan 29;73(2):885-96. Epub 2012 Nov 29.

Institute for Cancer Genetics, Columbia University Medical Center, New York, New York 10032, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-1880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548986PMC
January 2013

A blueprint for an international cancer epigenome consortium. A report from the AACR Cancer Epigenome Task Force.

Authors:
Stephan Beck Bradley E Bernstein Robert M Campbell Joseph F Costello Dashyant Dhanak Joseph R Ecker John M Greally Jean-Pierre Issa Peter W Laird Kornelia Polyak Benjamin Tycko Peter A Jones

Cancer Res 2012 Dec 27;72(24):6319-24. Epub 2012 Nov 27.

Research Department of Cancer Biology, University College London Cancer Institute, University College London, London, United Kingdom.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-12-3658DOI Listing
December 2012

Polymorphisms in HSD17B1: Early Onset and Increased Risk of Alzheimer's Disease in Women with Down Syndrome.

Authors:
Joseph H Lee Susan Gurney Deborah Pang Alexis Temkin Naeun Park Sarah C Janicki Warren B Zigman Wayne Silverman Benjamin Tycko Nicole Schupf

Curr Gerontol Geriatr Res 2012 4;2012:361218. Epub 2012 Mar 4.

The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1155/2012/361218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310186PMC
August 2012

Variants in CYP17 and CYP19 cytochrome P450 genes are associated with onset of Alzheimer's disease in women with down syndrome.

Authors:
Constance Chace Deborah Pang Catherine Weng Alexis Temkin Simon Lax Wayne Silverman Warren Zigman Michel Ferin Joseph H Lee Benjamin Tycko Nicole Schupf

J Alzheimers Dis 2012 ;28(3):601-12

The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA.

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http://dx.doi.org/10.3233/JAD-2011-110860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276705PMC
June 2012

Estrogen receptor-Beta variants are associated with increased risk of Alzheimer's disease in women with down syndrome.

Authors:
Qi Zhao Joseph H Lee Deborah Pang Alexis Temkin Naeun Park Sarah C Janicki Warren B Zigman Wayne Silverman Benjamin Tycko Nicole Schupf

Dement Geriatr Cogn Disord 2011 8;32(4):241-9. Epub 2011 Dec 8.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, G.H. Sergievsky Center, New York, N.Y., USA.

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http://dx.doi.org/10.1159/000334522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250648PMC
June 2012

Folic acid increases global DNA methylation and reduces inflammation to prevent Helicobacter-associated gastric cancer in mice.

Authors:
Tamas A Gonda Young-In Kim Martha C Salas Mary V Gamble Wataru Shibata Sureshkumar Muthupalani Kyoung-Jin Sohn Julian A Abrams James G Fox Timothy C Wang Benjamin Tycko

Gastroenterology 2012 Apr 13;142(4):824-833.e7. Epub 2012 Jan 13.

Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1053/j.gastro.2011.12.058DOI Listing
April 2012

HDAC inhibitors and decitabine are highly synergistic and associated with unique gene-expression and epigenetic profiles in models of DLBCL.

Authors:
Matko Kalac Luigi Scotto Enrica Marchi Jennifer Amengual Venkatraman E Seshan Govind Bhagat Netha Ulahannan Violetta V Leshchenko Alexis M Temkin Samir Parekh Benjamin Tycko Owen A O'Connor

Blood 2011 Nov 19;118(20):5506-16. Epub 2011 Jul 19.

New York University Cancer Institute, New York University Langone Medical Center, 522 First Avenue, New York, NY 10016, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-02-33
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http://dx.doi.org/10.1182/blood-2011-02-336891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217353PMC
November 2011

Epigenomic insights into common disease.

Authors:
Kate Revill Benjamin Tycko

Genome Med 2011 Nov 23;3(11):71. Epub 2011 Nov 23.

Cold Spring Harbor Laboratory, New York, NY 11794, USA.

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http://dx.doi.org/10.1186/gm287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308026PMC
November 2011

The caBIG® Life Science Business Architecture Model.

Authors:
Lauren Becnel Boyd Scott P Hunicke-Smith Grace A Stafford Elaine T Freund Michele Ehlman Uma Chandran Robert Dennis Anna T Fernandez Stephen Goldstein David Steffen Benjamin Tycko Juli D Klemm

Bioinformatics 2011 May 29;27(10):1429-35. Epub 2011 Mar 29.

Department of Medicine, Hematology/Oncology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1093/bioinformatics/btr141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087952PMC
May 2011

Cancer epigenetics and targeted therapies.

Authors:
Benjamin Tycko

Oncology (Williston Park) 2011 Mar;25(3):228, 231

Department of Pathology & Cell Biology and Institute for Cancer Genetics, Columbia University Medical Center, New York, New York, USA.

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March 2011

Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth.

Authors:
Michael Quante Shui Ping Tu Hiroyuki Tomita Tamas Gonda Sophie S W Wang Shigeo Takashi Gwang Ho Baik Wataru Shibata Bethany Diprete Kelly S Betz Richard Friedman Andrea Varro Benjamin Tycko Timothy C Wang

Cancer Cell 2011 Feb;19(2):257-72

Division of Digestive and Liver Diseases, Columbia University, New York, NY 10025, USA.

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http://ac.els-cdn.com/S1535610811000420/1-s2.0-S153561081100
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http://dx.doi.org/10.1016/j.ccr.2011.01.020DOI Listing
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February 2011

Altered DNA methylation in leukocytes with trisomy 21.

Authors:
Kristi Kerkel Nicole Schupf Kota Hatta Deborah Pang Martha Salas Alexander Kratz Mark Minden Vundavalli Murty Warren B Zigman Richard P Mayeux Edmund C Jenkins Ali Torkamani Nicholas J Schork Wayne Silverman B Anne Croy Benjamin Tycko

PLoS Genet 2010 Nov 18;6(11):e1001212. Epub 2010 Nov 18.

Institute for Cancer Genetics, Columbia University Medical Center, New York, NY, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987931PMC
November 2010

Allele-specific DNA methylation: beyond imprinting.

Authors:
Benjamin Tycko

Hum Mol Genet 2010 Oct 20;19(R2):R210-20. Epub 2010 Sep 20.

Institute for Cancer Genetics and Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1093/hmg/ddq376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953749PMC
October 2010

Genome-wide divergence of DNA methylation marks in cerebral and cerebellar cortices.

Authors:
Yurong Xin Benjamin Chanrion Meng-Min Liu Hanga Galfalvy Ramiro Costa Boro Ilievski Gorazd Rosoklija Victoria Arango Andrew J Dwork J John Mann Benjamin Tycko Fatemeh Haghighi

PLoS One 2010 Jun 28;5(6):e11357. Epub 2010 Jun 28.

Department of Psychiatry, Columbia University and The New York State Psychiatric Institute, New York, New York, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893206PMC
June 2010

Molecular biology of cancer-associated fibroblasts: can these cells be targeted in anti-cancer therapy?

Authors:
Tamas A Gonda Andrea Varro Timothy C Wang Benjamin Tycko

Semin Cell Dev Biol 2010 Feb 17;21(1):2-10. Epub 2009 Oct 17.

Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531978PMC
February 2010

Mapping allele-specific DNA methylation: a new tool for maximizing information from GWAS.

Authors:
Benjamin Tycko

Am J Hum Genet 2010 Feb;86(2):109-12

Institute for Cancer Genetics and Taub Institute, Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.ajhg.2010.01.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820186PMC
February 2010

Methods in DNA methylation profiling.

Authors:
Tao Zuo Benjamin Tycko Ta-Ming Liu Juey-Jen L Lin Tim H-M Huang

Epigenomics 2009 Dec;1(2):331-45

Division of Human Cancer Genetics, Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.2217/epi.09.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880494PMC
December 2009

Global hypomethylation of genomic DNA in cancer-associated myofibroblasts.

Authors:
Le Jiang Tamas A Gonda Mary V Gamble Martha Salas Venkatraman Seshan Shuiping Tu William S Twaddell Peter Hegyi Gyorgy Lazar Islay Steele Andrea Varro Timothy C Wang Benjamin Tycko

Cancer Res 2008 Dec;68(23):9900-8

Institute for Cancer Genetics and Department of Medicine, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-1319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670548PMC
December 2008

Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation.

Authors:
Kristi Kerkel Alexandra Spadola Eric Yuan Jolanta Kosek Le Jiang Eldad Hod Kerry Li Vundavalli V Murty Nicole Schupf Eric Vilain Mitzi Morris Fatemeh Haghighi Benjamin Tycko

Nat Genet 2008 Jul 22;40(7):904-8. Epub 2008 Jun 22.

Institute for Cancer Genetics, Columbia University Medical Center, New York, New York 10032, USA.

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July 2008

Estrogen receptor-alpha variants increase risk of Alzheimer's disease in women with Down syndrome.

Authors:
Nicole Schupf Joseph H Lee Michelle Wei Deborah Pang Constance Chace Rong Cheng Warren B Zigman Benjamin Tycko Wayne Silverman

Dement Geriatr Cogn Disord 2008 14;25(5):476-82. Epub 2008 Apr 14.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, G.H. Sergievsky Center, New York, NY, USA.

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http://dx.doi.org/10.1159/000126495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430887PMC
June 2008

Successful aging in a 70-year-old man with down syndrome: a case study.

Authors:
Sharon J Krinsky-McHale Darlynne A Devenny Hong Gu Edmund C Jenkins Phyllis Kittler Vundavalli V Murty Nicole Schupf Luigi Scotto Benjamin Tycko Tiina K Urv Lingling Ye Warren B Zigman Wayne Silverman

Intellect Dev Disabil 2008 Jun;46(3):215-28

New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA.

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http://dx.doi.org/10.1352/2008.46:215-228DOI Listing
June 2008

Age-at-onset linkage analysis in Caribbean Hispanics with familial late-onset Alzheimer's disease.

Authors:
Joseph H Lee Sandra Barral Rong Cheng Inara Chacon Vincent Santana Jennifer Williamson Rafael Lantigua Martin Medrano Ivonne Z Jimenez-Velazquez Yaakov Stern Benjamin Tycko Ekaterina Rogaeva Yosuke Wakutani Toshitaka Kawarai Peter St George-Hyslop Richard Mayeux

Neurogenetics 2008 Feb 17;9(1):51-60. Epub 2007 Oct 17.

The Taub Institute on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1007/s10048-007-0103-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701253PMC
February 2008

A pathologic link between Wilms tumor suppressor gene, WT1, and IFI16.

Authors:
Marianne K-H Kim Jacqueline M Mason Chi-Ming Li Windy Berkofsky-Fessler Le Jiang Divaker Choubey Paul E Grundy Benjamin Tycko Jonathan D Licht

Neoplasia 2008 Jan;10(1):69-78

Division of Hematology/Oncology, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1593/neo.07869DOI Listing
January 2008

The Wnt/beta-catenin pathway in Wilms tumors and prostate cancers.

Authors:
Benjamin Tycko Chi-Ming Li Ralph Buttyan

Curr Mol Med 2007 Aug;7(5):479-89

Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.2174/156652407781387118DOI Listing
August 2007

Cholesterol level, statin use and Alzheimer's disease in adults with Down syndrome.

Authors:
Warren B Zigman Nicole Schupf Edmund C Jenkins Tiina K Urv Benjamin Tycko Wayne Silverman

Neurosci Lett 2007 Apr 11;416(3):279-84. Epub 2007 Feb 11.

Department of Psychology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, United States.

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http://dx.doi.org/10.1016/j.neulet.2007.02.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892238PMC
April 2007

Faithful tissue-specific expression of the human chromosome 21-linked COL6A1 gene in BAC-transgenic mice.

Authors:
Luzhou Xing Martha Salas Chyuan-Sheng Lin Warren Zigman Wayne Silverman Shivakumar Subramaniyam Vundavalli V Murty Benjamin Tycko

Mamm Genome 2007 Feb 28;18(2):113-22. Epub 2007 Feb 28.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York 10032, USA.

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http://dx.doi.org/10.1007/s00335-006-0082-yDOI Listing
February 2007

Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2.

Authors:
T Néstor H Masckauchán Dritan Agalliu Marina Vorontchikhina Audrey Ahn Nancy L Parmalee Chi-Ming Li Alan Khoo Benjamin Tycko Anthony M C Brown Jan Kitajewski

Mol Biol Cell 2006 Dec 11;17(12):5163-72. Epub 2006 Oct 11.

Obstetrics and Gynecology, Columbia University Medical Center, New York, NY 10032, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1679681PMC
December 2006

Apolipoprotein E epsilon4 and age at onset of sporadic and familial Alzheimer disease in Caribbean Hispanics.

Authors:
Lucia Olarte Nicole Schupf Joseph H Lee Ming-Xin Tang Vincent Santana Jennifer Williamson Prashanthi Maramreddy Benjamin Tycko Richard Mayeux

Arch Neurol 2006 Nov;63(11):1586-90

Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

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http://dx.doi.org/10.1001/archneur.63.11.1586DOI Listing
November 2006

Expanded genomewide scan implicates a novel locus at 3q28 among Caribbean hispanics with familial Alzheimer disease.

Authors:
Joseph H Lee Rong Cheng Vincent Santana Jennifer Williamson Rafael Lantigua Martin Medrano Alex Arriaga Yaakov Stern Benjamin Tycko Ekaterina Rogaeva Yosuke Wakutani Toshitaka Kawarai Peter St George-Hyslop Richard Mayeux

Arch Neurol 2006 Nov;63(11):1591-8

Gertrude H. Sergievsky Center, Columbia University, 630 W 168th St, New York, NY 10032, USA.

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http://dx.doi.org/10.1001/archneur.63.11.1591DOI Listing
November 2006

A single nucleotide polymorphism chip-based method for combined genetic and epigenetic profiling: validation in decitabine therapy and tumor/normal comparisons.

Authors:
Eric Yuan Fatemeh Haghighi Susan White Ramiro Costa Julie McMinn Kathy Chun Mark Minden Benjamin Tycko

Cancer Res 2006 Apr;66(7):3443-51

Institute for Cancer Genetics, Columbia University Medical Center, 1150 St. Nicholas Avenue, New York, NY 10032, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-3739DOI Listing
April 2006

Cell type-specific over-expression of chromosome 21 genes in fibroblasts and fetal hearts with trisomy 21.

Authors:
Chi-Ming Li Meirong Guo Martha Salas Nicole Schupf Wayne Silverman Warren B Zigman Sameera Husain Dorothy Warburton Harshwardhan Thaker Benjamin Tycko

BMC Med Genet 2006 Mar 15;7:24. Epub 2006 Mar 15.

Institute for Cancer Genetics, Columbia University College of Physicians and Surgeons, New York, NY, USA.

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http://dx.doi.org/10.1186/1471-2350-7-24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1435874PMC
March 2006

PEG10 is a c-MYC target gene in cancer cells.

Authors:
Chi-Ming Li Adam A Margolin Martha Salas Lorenzo Memeo Mahesh Mansukhani Hanina Hibshoosh Matthias Szabolcs Apostolos Klinakis Benjamin Tycko

Cancer Res 2006 Jan;66(2):665-72

Institute for Cancer Genetics, Columbia University Medical Center, 1150 St. Nicholas Avenue, New York, NY 10032, USA.

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January 2006

Mortality is associated with apolipoprotein E epsilon4 in nondemented adults with Down syndrome.

Authors:
Warren B Zigman Edmund C Jenkins Benjamin Tycko Nicole Schupf Wayne Silverman

Neurosci Lett 2005 Dec 24;390(2):93-7. Epub 2005 Aug 24.

New York State Institute For Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314-6399, USA.

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December 2005

Genomic profiling maps loss of heterozygosity and defines the timing and stage dependence of epigenetic and genetic events in Wilms' tumors.

Authors:
Eric Yuan Chi-Ming Li Darrell J Yamashiro Jessica Kandel Harshwardhan Thaker Vundavalli V Murty Benjamin Tycko

Mol Cancer Res 2005 Sep;3(9):493-502

Institute for Cancer Genetics, Division of Pathology,Columbia University Medical Center, New York, New York 10032, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-05-0082DOI Listing
September 2005

Two somatic biallelic lesions within and near SMAD4 in a human breast cancer cell line.

Authors:
John Jakob Satoru Nagase Adi Gazdar Minchen Chien Irina Morozova James J Russo Subhadra V Nandula Vundavalli V V S Murty Chi-Ming Li Benjamin Tycko Ramon Parsons

Genes Chromosomes Cancer 2005 Apr;42(4):372-83

Institute for Cancer Genetics, Columbia University, Russ Berrie Pavilion, 1150 St. Nicholas Avenue, New York, NY 10032, USA.

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http://doi.wiley.com/10.1002/gcc.20142
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April 2005

Altered PET functional brain responses in cognitively intact elderly persons at risk for Alzheimer disease (carriers of the epsilon4 allele).

Authors:
Nikolaos Scarmeas Christian Habeck Karen E Anderson John Hilton Davangere P Devanand Gregory H Pelton Matthias H Tabert Joseph Flynn Aileen Park Alejandra Ciappa Benjamin Tycko Yaakov Stern

Am J Geriatr Psychiatry 2004 Nov-Dec;12(6):596-605

Departments of Neurology,College of Physicians and Surgeons of Columbia University Medical Center; 622 West 168th St., PH 19th floor; New York, NY 10032, USA.

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http://dx.doi.org/10.1176/appi.ajgp.12.6.596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025285PMC
February 2005

CTNNB1 mutations and overexpression of Wnt/beta-catenin target genes in WT1-mutant Wilms' tumors.

Authors:
Chi-Ming Li Connie E Kim Adam A Margolin Meirong Guo Jimmy Zhu Jacqueline M Mason Terrence W Hensle Vundavalli V V S Murty Paul E Grundy Eric R Fearon Vivette D'Agati Jonathan D Licht Benjamin Tycko

Am J Pathol 2004 Dec;165(6):1943-53

Institute of Cancer Genetics, Columbia University College of Physicians and Surgeons, New York, New York, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618727PMC
http://dx.doi.org/10.1016/s0002-9440(10)63246-4DOI Listing
December 2004

Preservation of cognitive and functional ability as markers of longevity.

Authors:
Nicole Schupf Rosann Costa Ming-Xin Tang Howard Andrews Benjamin Tycko Joseph H Lee Richard Mayeux

Neurobiol Aging 2004 Oct;25(9):1231-40

G.H. Sergievsky Center, Taub Institute for Research on Alzheimer's Disease, Department of Epidemiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2003.11.010DOI Listing
October 2004

Placental growth retardation due to loss of imprinting of Phlda2.

Authors:
Martha Salas Rosalind John Anjana Saxena Sheila Barton Dale Frank Galina Fitzpatrick Michael J Higgins Benjamin Tycko

Mech Dev 2004 Oct;121(10):1199-210

Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.mod.2004.05.017DOI Listing
October 2004

APOE and APOC1 promoter polymorphisms and the risk of Alzheimer disease in African American and Caribbean Hispanic individuals.

Authors:
Benjamin Tycko Joseph H Lee Alejandra Ciappa Anjana Saxena Chi-Ming Li Lin Feng Alex Arriaga Yaakov Stern Rafael Lantigua Neil Shachter Richard Mayeux

Arch Neurol 2004 Sep;61(9):1434-9

Department of Pathology, Division of Neuropathology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.

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http://dx.doi.org/10.1001/archneur.61.9.1434DOI Listing
September 2004

Immunohistochemistry for the imprinted gene product IPL/PHLDA2 for facilitating the differential diagnosis of complete hydatidiform mole.

Authors:
Harshwardhan M Thaker Ana Berlin Benjamin Tycko Donald P Goldstein Ross S Berkowitz Diego H Castrillon David R Genest

J Reprod Med 2004 Aug;49(8):630-6

Department of Pathology, Institute for Cancer Genetics, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA.

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August 2004

TP73 allelic expression in human brain and allele frequencies in Alzheimer's disease.

Authors:
Quanyi Li Eleni S Athan Michelle Wei Eric Yuan Samuel L Rice Jean-Paul Vonsattel Richard P Mayeux Benjamin Tycko

BMC Med Genet 2004 Jun 2;5:14. Epub 2004 Jun 2.

Taub Institute for Research on Alzheimer's disease and the Aging Brain, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1186/1471-2350-5-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC420466PMC
June 2004

Thirtyfold multiplex genotyping of the p53 gene using solid phase capturable dideoxynucleotides and mass spectrometry.

Authors:
Sobin Kim Michael E Ulz Tuan Nguyen Chi-Ming Li Takaaki Sato Benjamin Tycko Jingyue Ju

Genomics 2004 May;83(5):924-31

Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S088875430300369
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http://dx.doi.org/10.1016/j.ygeno.2003.11.012DOI Listing
May 2004

The history of cancer epigenetics.

Authors:
Andrew P Feinberg Benjamin Tycko

Nat Rev Cancer 2004 02;4(2):143-53

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1038/nrc1279DOI Listing
February 2004

Onset of dementia is associated with age at menopause in women with Down's syndrome.

Authors:
Nicole Schupf Deborah Pang Bindu N Patel Wayne Silverman Romaine Schubert Florence Lai Jennie K Kline Yaakov Stern Michel Ferin Benjamin Tycko Richard Mayeux

Ann Neurol 2003 Oct;54(4):433-8

The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1002/ana.10677DOI Listing
October 2003

The Saitohin 'Q7R' polymorphism and tau haplotype in multi-ethnic Alzheimer disease and Parkinson's disease cohorts.

Authors:
Lorraine N Clark Gilberto Levy Ming-Xin Tang Helen Mejia-Santana Alejandra Ciappa Benjamin Tycko Lucien J Cote Elan D Louis Richard Mayeux Karen Marder

Neurosci Lett 2003 Aug;347(1):17-20

Department of Pathology, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1016/s0304-3940(03)00635-9DOI Listing
August 2003

Biallelic expression of HRAS and MUCDHL in human and mouse.

Authors:
Michael Goldberg Michelle Wei Luwa Yuan Vundavalli V Murty Benjamin Tycko

Hum Genet 2003 Apr 14;112(4):334-42. Epub 2003 Feb 14.

Department of Pediatrics, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA.

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http://link.springer.de/link/service/journals/00439/contents
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http://dx.doi.org/10.1007/s00439-003-0907-7DOI Listing
April 2003

Genetic and epigenetic mosaicism in cancer precursor tissues.

Authors:
Benjamin Tycko

Ann N Y Acad Sci 2003 Mar;983:43-54

Institute for Cancer Genetics and Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2003.tb05961.xDOI Listing
March 2003

Regulation of supply and demand for maternal nutrients in mammals by imprinted genes.

Authors:
Wolf Reik Miguel Constância Abigail Fowden Neil Anderson Wendy Dean Anne Ferguson-Smith Benjamin Tycko Colin Sibley

J Physiol 2003 Feb 24;547(Pt 1):35-44. Epub 2003 Jan 24.

Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK.

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http://www.jphysiol.org/cgi/doi/10.1113/jphysiol.2002.033274
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2342627PMC
February 2003

Phosphoinositide binding by the pleckstrin homology domains of Ipl and Tih1.

Authors:
Anjana Saxena Pavel Morozov Dale Frank Raymond Musalo Mark A Lemmon Edward Y Skolnik Benjamin Tycko

J Biol Chem 2002 Dec 8;277(51):49935-44. Epub 2002 Oct 8.

Institute for Cancer Genetics, Department of Pathology, Columbia University, 1150 St. Nicholas Avenue, New York, NY 10032, USA.

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http://dx.doi.org/10.1074/jbc.M206497200DOI Listing
December 2002

Polymorphisms in the promoter of the human APP gene: functional evaluation and allele frequencies in Alzheimer disease.

Authors:
Eleni S Athan Joseph H Lee Alex Arriaga Richard P Mayeux Benjamin Tycko

Arch Neurol 2002 Nov;59(11):1793-9

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY, USA.

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http://dx.doi.org/10.1001/archneur.59.11.1793DOI Listing
November 2002

Chromosome arm 16q in Wilms tumors: unbalanced chromosomal translocations, loss of heterozygosity, and assessment of the CTCF gene.

Authors:
Albert Yeh Michelle Wei Samuel B Golub Darrell J Yamashiro Vundavali V Murty Benjamin Tycko

Genes Chromosomes Cancer 2002 Oct;35(2):156-63

Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York, USA.

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http://doi.wiley.com/10.1002/gcc.10110
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October 2002

Physiological functions of imprinted genes.

Authors:
Benjamin Tycko Ian M Morison

J Cell Physiol 2002 Sep;192(3):245-58

Institute for Cancer Genetics, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1002/jcp.10129DOI Listing
September 2002

Identification and expression analysis of the human mu-protocadherin gene in fetal and adult kidneys.

Authors:
Michael Goldberg Michelle Wei Benjamin Tycko Inna Falikovich Dorothy Warburton

Am J Physiol Renal Physiol 2002 Sep;283(3):F454-63

Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.

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http://www.physiology.org/doi/10.1152/ajprenal.00012.2002
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September 2002

Reactivation of a silenced H19 gene in human rhabdomyosarcoma by demethylation of DNA but not by histone hyperacetylation.

Authors:
Catherine A Lynch Benjamin Tycko Timothy H Bestor Colum P Walsh

Mol Cancer 2002 Jul 11;1. Epub 2002 Jul 11.

Cancer and Ageing Research Group, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC119368PMC
July 2002

Gene expression in Wilms' tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition.

Authors:
Chi-Ming Li Meirong Guo Alain Borczuk Charles A Powell Michelle Wei Harshwardhan M Thaker Richard Friedman Ulf Klein Benjamin Tycko

Am J Pathol 2002 Jun;160(6):2181-90

Institute for Cancer Genetics, Columbia University, New York, New York, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850829PMC
http://dx.doi.org/10.1016/S0002-9440(10)61166-2DOI Listing
June 2002

Genomic imprinting: piece of cake.

Authors:
Benjamin Tycko Argiris Efstratiadis

Nature 2002 Jun;417(6892):913-4

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http://dx.doi.org/10.1038/417913aDOI Listing
June 2002

The Tnfrh1 (Tnfrsf23) gene is weakly imprinted in several organs and expressed at the trophoblast-decidua interface.

Authors:
Lorraine Clark Michelle Wei Giorgio Cattoretti Cathy Mendelsohn Benjamin Tycko

BMC Genet 2002 Jun 27;3:11. Epub 2002 Jun 27.

Institute for Cancer Genetics, Columbia University College of Physicians and Surgeons, New York, NY, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC117226PMC
http://dx.doi.org/10.1186/1471-2156-3-11DOI Listing
June 2002

Placental overgrowth in mice lacking the imprinted gene Ipl.

Authors:
Dale Frank Weiwei Fortino Lorraine Clark Raymond Musalo Wenxian Wang Anjana Saxena Chi-Ming Li Wolf Reik Thomas Ludwig Benjamin Tycko

Proc Natl Acad Sci U S A 2002 May;99(11):7490-5

Institute for Cancer Genetics, Department of Pathology, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1073/pnas.122039999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC124258PMC
May 2002

Familial Alzheimer disease among Caribbean Hispanics: a reexamination of its association with APOE.

Authors:
Stavra N Romas Vincent Santana Jennifer Williamson Alejandra Ciappa Joseph H Lee Haydee Z Rondon Pedro Estevez Rafael Lantigua Martin Medrano Mayobanex Torres Yaakov Stern Benjamin Tycko Richard Mayeux

Arch Neurol 2002 Jan;59(1):87-91

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, 630 W 168th St, New York, NY 10032, USA.

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http://dx.doi.org/10.1001/archneur.59.1.87DOI Listing
January 2002