Publications by authors named "Benjamin Meder"

100Publications

iPSC Modeling of RBM20-Deficient DCM Identifies Upregulation of RBM20 as a Therapeutic Strategy.

Cell Rep 2020 Sep;32(10):108117

European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany; Department of Genetics, School of Medicine, Stanford University, Stanford, CA, USA; Cardiovascular Institute and Department of Medicine, Stanford University, Stanford, CA, USA; Stanford Genome Technology Center, Stanford University, Palo Alto, CA, USA; DZHK: German Center for Cardiovascular Research, Partner Site EMBL Heidelberg, Heidelberg, Germany. Electronic address:

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September 2020

Generation of pluripotent stem cell lines and CRISPR/Cas9 modified isogenic controls from a patient with dilated cardiomyopathy harboring a RBM20 p.R634W mutation.

Stem Cell Res 2020 Jul 2;47:101901. Epub 2020 Jul 2.

Clinic for Cardiology and Pneumology, University Medical Center Göttingen, Göttingen, Germany; German Center of Cardiovascular Research (DZHK), Germany. Electronic address:

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July 2020

Deep Characterization of Circular RNAs from Human Cardiovascular Cell Models and Cardiac Tissue.

Cells 2020 07 4;9(7). Epub 2020 Jul 4.

Section of Bioinformatics and Systems Cardiology, Klaus Tschira Institute for Integrative Computational Cardiology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

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July 2020

Machine learning-based risk prediction of intrahospital clinical outcomes in patients undergoing TAVI.

Clin Res Cardiol 2020 Jun 24. Epub 2020 Jun 24.

Department of Internal Medicine III, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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June 2020

Epigenetic Regulation of Alternative mRNA Splicing in Dilated Cardiomyopathy.

J Clin Med 2020 May 16;9(5). Epub 2020 May 16.

Institute for Cardiomyopathies Heidelberg (ICH), Heart Center Heidelberg, University of Heidelberg, 69121 Heidelberg, Germany.

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May 2020

Age-Related Variations in Takotsubo Syndrome.

Authors:
Victoria L Cammann Konrad A Szawan Barbara E Stähli Ken Kato Monika Budnik Manfred Wischnewsky Sara Dreiding Rena A Levinson Davide Di Vece Sebastiano Gili Rodolfo Citro Eduardo Bossone Michael Neuhaus Jennifer Franke Benjamin Meder Miłosz Jaguszewski Michel Noutsias Maike Knorr Susanne Heiner Fabrizio D'Ascenzo Wolfgang Dichtl Christof Burgdorf Behrouz Kherad Carsten Tschöpe Annahita Sarcon Jerold Shinbane Lawrence Rajan Guido Michels Roman Pfister Alessandro Cuneo Claudius Jacobshagen Mahir Karakas Wolfgang Koenig Alexander Pott Philippe Meyer Marco Roffi Adrian Banning Mathias Wolfrum Florim Cuculi Richard Kobza Thomas A Fischer Tuija Vasankari K E Juhani Airaksinen L Christian Napp Rafal Dworakowski Philip MacCarthy Christoph Kaiser Stefan Osswald Leonarda Galiuto Christina Chan Paul Bridgman Daniel Beug Clément Delmas Olivier Lairez Ekaterina Gilyarova Alexandra Shilova Mikhail Gilyarov Ibrahim El-Battrawy Ibrahim Akin Karolina Poledniková Petr Toušek David E Winchester Jan Galuszka Christian Ukena Gregor Poglajen Pedro Carrilho-Ferreira Christian Hauck Carla Paolini Claudio Bilato Yoshio Kobayashi Toshihiro Shoji Iwao Ishibashi Masayuki Takahara Toshiharu Himi Jehangir Din Ali Al-Shammari Abhiram Prasad Charanjit S Rihal Kan Liu P Christian Schulze Matteo Bianco Lucas Jörg Hans Rickli Gonçalo Pestana Thanh H Nguyen Michael Böhm Lars S Maier Fausto J Pinto Petr Widimský Stephan B Felix Ruediger C Braun-Dullaeus Wolfgang Rottbauer Gerd Hasenfuß Burkert M Pieske Heribert Schunkert Martin Borggrefe Holger Thiele Johann Bauersachs Hugo A Katus John D Horowitz Carlo Di Mario Thomas Münzel Filippo Crea Jeroen J Bax Thomas F Lüscher Frank Ruschitzka Jelena R Ghadri Grzegorz Opolski Christian Templin

J Am Coll Cardiol 2020 04;75(16):1869-1877

University Heart Center, Department of Cardiology, University Hospital Zurich, Zurich, Switzerland. Electronic address:

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April 2020

microRNA neural networks improve diagnosis of acute coronary syndrome (ACS).

J Mol Cell Cardiol 2020 Apr 17. Epub 2020 Apr 17.

Department of Internal Medicine III, Heidelberg University, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), Germany; Department of Genetics, Stanford Genome Technology Center, Stanford University School of Medicine, Stanford, CA, USA. Electronic address:

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April 2020

Predicting sustained ventricular arrhythmias in dilated cardiomyopathy: a meta-analysis and systematic review.

ESC Heart Fail 2020 08 14;7(4):1430-1441. Epub 2020 Apr 14.

Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

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August 2020

Postcardiac injury syndrome after cardiac implantable electronic device implantation.

Herz 2020 Nov 13;45(7):696-702. Epub 2020 Mar 13.

Department of Medicine III, Universitätsklinikum Heidelberg, INF 410, 69120, Heidelberg, Germany.

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November 2020

Heart-Specific Immune Responses in an Animal Model of Autoimmune-Related Myocarditis Mitigated by an Immunoproteasome Inhibitor and Genetic Ablation.

Circulation 2020 Jun 12;141(23):1885-1902. Epub 2020 Mar 12.

Institute of Biochemistry (C.C.G., H.L.N., M.K., A.B.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health (BIH), Germany.

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June 2020

Pulmonary vein isolation treats symptomatic AF in a patient with Lamin A/C mutation: case report and review of the literature.

Clin Res Cardiol 2020 Aug 6;109(8):1070-1075. Epub 2020 Mar 6.

Department of Cardiology, Medical University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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August 2020

The C-terminal HCN4 variant P883R alters channel properties and acts as genetic modifier of atrial fibrillation and structural heart disease.

Biochem Biophys Res Commun 2019 10 31;519(1):141-147. Epub 2019 Aug 31.

Department of Cardiology, Medical University Hospital Heidelberg, INF 410, D-69120, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), Partner site Heidelberg/Mannheim, INF 410, D-69120, Heidelberg, Germany. Electronic address:

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October 2019

Clinical and genetic insights into non-compaction: a meta-analysis and systematic review on 7598 individuals.

Clin Res Cardiol 2019 Nov 12;108(11):1297-1308. Epub 2019 Apr 12.

Department of Medicine III, Institute for Cardiomyopathy, University of Heidelberg, INF 410, 69120, Heidelberg, Germany.

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November 2019

ANK2 functionally interacts with KCNH2 aggravating long QT syndrome in a double mutation carrier.

Biochem Biophys Res Commun 2019 05 28;512(4):845-851. Epub 2019 Mar 28.

Department of Cardiology, Medical University Hospital Heidelberg, INF 410, D-69120, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, University of Heidelberg, INF 410, D-69120, Heidelberg, Germany. Electronic address:

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May 2019

[Digital Cardiology].

Dtsch Med Wochenschr 2019 04 29;144(7):447-451. Epub 2019 Mar 29.

Klinik für Innere Medizin und Kardiologie, Schön Klinik Neustadt.

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April 2019

Identification and regulation of the long non-coding RNA Heat2 in heart failure.

J Mol Cell Cardiol 2019 01 13;126:13-22. Epub 2018 Nov 13.

Department of Cardiology, Internal Medicine III, Goethe-University Hospital, Theodor Stern Kai 7, Frankfurt, Germany; German Centre for Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany; Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany.

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January 2019

Periprocedural antibiotic treatment in transvascular aortic valve replacement.

J Interv Cardiol 2018 Dec 5;31(6):885-890. Epub 2018 Nov 5.

Department of Internal Medicine III, University of Heidelberg, Heidelberg, Germany.

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December 2018

Genetic Reduction in Left Ventricular Protein Kinase C-α and Adverse Ventricular Remodeling in Human Subjects.

Circ Genom Precis Med 2018 03;11(3):e001901

From the Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.H., M.P.M., J.B., K.B.M., T.P.C.); Cardiovascular Research Center (N.R.T., V.A.P., P.T.E.) and Center for Human Genetic Research and Cardiovascular Research Center (C.N.-C.), Massachusetts General Hospital, Boston; Department of Statistics, University of Illinois at Urbana-Champaign (S.D.Z.); Heidelberg University Hospital, Germany (B.M., H.A.K.); Department of Genetic Epidemiology, Institute of Human Genetics, University of Münster, Germany (F.R., M.S.); INSERM UMRS1166-IACN, Hôpital Pitié-Salpêtrière, Paris, France (E.V., F.C.); Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, MA (H.L.); Department of Epidemiology, University of Washington, Seattle (N.L.S.); Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands (J.F.F.); Boston University School of Medicine, MA (R.S.V.); Department of Cardiology, University of Groningen, University Medical Center Groningen, the Netherlands (P.v.d.H.); Medical and Population Genetics Program, Broad Institute, Cambridge, MA (C.N.-C.); Center for Applied Genomics, Children's Hospital of Philadelphia, PA (J.L., C.E.K., H.H.); Center for Bioinformatics and Computational Biology, University of Maryland, College Park (S.H.); Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, CA (E.A.A.); Department of Cardiovascular Medicine, Cleveland Clinic, OH (C.S.M., W.H.W.T.); and Howard Hughes Medical Institute and Cincinnati Children's Hospital Medical Center, OH (M.M., J.D.M.).

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March 2018

Left Ventricular Biopsy in the Diagnosis of Myocardial Diseases.

Circulation 2018 03;137(10):993-995

Institute for Cardiomyopathies Heidelberg and Department of Internal Medicine III, University of Heidelberg, Germany (B.M., H.A.K.).

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March 2018

Clinical outcomes associated with sarcomere mutations in hypertrophic cardiomyopathy: a meta-analysis on 7675 individuals.

Clin Res Cardiol 2018 Jan 24;107(1):30-41. Epub 2017 Aug 24.

Institute for Cardiomyopathy, Department of Medicine III, University of Heidelberg, INF 410, 69120, Heidelberg, Germany.

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January 2018

Epigenome-Wide Association Study Identifies Cardiac Gene Patterning and a Novel Class of Biomarkers for Heart Failure.

Circulation 2017 Oct 24;136(16):1528-1544. Epub 2017 Aug 24.

From Department of Internal Medicine III, Institute for Cardiomyopathies, University of Heidelberg, Germany (B.M., J.H., F.S.-H., E.K., K.F., A.L., R.N., C.S., S.M., D.M.-B., A.A., H.H., D.B.H., M.M.-H., T.W., H.A.K.); Siemens Healthcare GmbH, Strategy and Innovation, Erlangen, Germany (C.D., M.W., A.E.P.); Department of Bioinformatics, University of Saarland, Saarbrücken, Germany (A.K.); German Centre for Cardiovascular Research, Berlin, Germany (B.M., J.H., F.S.-H., E.K., K.F., A.L., D.S., M.M.-H., T.W., J.B., H.A.K.); Institute for Molecular Cardiology and Epigenetics, University of Heidelberg, Germany (D.S., J.B.); Funktionelle Genomanalyse, Deutsches Krebsforschungszentrum, Heidelberg, Germany (A.B.); Department of Cardiac Surgery, University of Heidelberg, Germany (A.R.); Siemens AG, Corporate Technology, Vienna, Austria (D.P.); Section for Clinical Biometrics, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Austria (D.P.); and Division of Epigenomics and Cancer Risk Factors, Deutsches Krebsforschungszentrum, Heidelberg, Germany (D.W., C.P.).

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October 2017

TranslatiOnal Registry for CardiomyopatHies (TORCH) - rationale and first results.

ESC Heart Fail 2017 Aug 14;4(3):209-215. Epub 2017 Mar 14.

Department of Cardiology, Medical University Hospital Heidelberg, Germany.

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August 2017

Identification and Functional Characterization of Hypoxia-Induced Endoplasmic Reticulum Stress Regulating lncRNA (HypERlnc) in Pericytes.

Circ Res 2017 Aug 13;121(4):368-375. Epub 2017 Jun 13.

From the Institute of Cardiovascular Regeneration, Centre of Molecular Medicine (F.C.B., A.W., D.J., M.-T.M., P.G., S.F.G., S.D., S.U., K.M.M., S.D., C.M.Z.); ZIM III, Department of Cardiology (F.C.B., A.W., S.F.G., A.M.Z., C.M.Z.), Goethe University, Frankfurt am Main, Germany; Department of Internal Medicine III, University of Heidelberg, Germany (J.-N.B., B.M., H.A.K., J.H.); DZHK (Deutsches Zentrum für Herz-Kreislaufforschung), Berlin, Germany (F.C.B., D.J., J.-N.B., S.D., S.U., B.M., H.A.K., J.H., W.C., A.M.Z., S.D., C.M.Z.); Cardiovascular Innovation Institute, University of Louisville, KY (S.U.); Laboratory for Novel Sequencing Technology, Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max-Delbrück-Centrum für Molekulare Medizin, Germany (W.C.); Department of Biology, Southern University of Science and Technology, Shenzhen, China (W.C.); Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany (S.S.P., W.S.); Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the DZL, Justus Liebig University, Germany (S.S.P., W.S.).

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August 2017

Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives.

Eur Heart J 2018 08;39(29):2704-2716

Department of Cardiology, CBF, CC11, Charite Universitätsmedizin Berlin, Campus Benjamin Franklin, Charite Centrum 11 (Cardiovascular Medicine), Hindenburgdamm 20, Berlin, Germany.

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August 2018

Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure.

Circulation 2017 Feb 7;135(9):881-897. Epub 2016 Dec 7.

From Institute of Experimental and Clinical Pharmacology and Toxicology, Mannheim Medical Faculty (I.H.A.-T., N.M.W., K.S., C.V., S.L., T.W.), and Department of Internal Medicine III (H.-J.H., N.M.W., M.M., B.M., H.-A.K., L.H.L., J.B.), Heidelberg University, Heidelberg-Mannheim, Germany; Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Essen, Germany (I.H.A.-T., J.H., M.S., N.V., D.D.); Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Germany (A.E.-A., C.M.W., S.L.); Department of Pharmacology and Toxicology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Germany (A.E.-A.); Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Germany (V.O.N.); Department of Internal Medicine II, University of Regensburg, Germany (S.N.); Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged, Hungary (I.B., A.V.); Division of Nephrology, New York University Langone Medical Center, New York (E.Y.S.); and DZHK (German Center for Cardiovascular Research), Partner Site HD/MA, Heidelberg-Mannheim, Germany (B.M., H.A.K., C.V., J.B., T.W.). The current affiliation for H.-J.H. is the Department of Cardiology and Angiology, University Hospital Schleswig-Holstein, Kiel, Germany.

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February 2017

microRNA assays for acute coronary syndromes.

Diagnosis (Berl) 2016 Dec;3(4):183-188

1Institute for Cardiomyopathies Heidelberg, Department of Cardiology, Angiology and Pulmology, University of Heidelberg, Heidelberg, Germany.

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December 2016

Initial Single-Center Experience With the Fully Repositionable Transfemoral Lotus Aortic Valve System.

J Invasive Cardiol 2017 Jan 15;29(1):30-35. Epub 2016 Nov 15.

Department of Cardiology, Angiology & Pulmology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.

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January 2017

Genotype-phenotype associations in dilated cardiomyopathy: meta-analysis on more than 8000 individuals.

Clin Res Cardiol 2017 Feb 30;106(2):127-139. Epub 2016 Aug 30.

Department of Medicine III, University of Heidelberg, INF 410, 69120, Heidelberg, Germany.

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February 2017

Computational Cardiology - A New Discipline of Translational Research.

Genomics Proteomics Bioinformatics 2016 08 3;14(4):177-8. Epub 2016 Aug 3.

Chair for Clinical Bioinformatics, Medical Faculty, Saarland University, 66123 Saarbrücken, Germany. Electronic address:

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August 2016

Personalized Computer Simulation of Diastolic Function in Heart Failure.

Genomics Proteomics Bioinformatics 2016 08 29;14(4):244-52. Epub 2016 Jul 29.

Institute for Cardiomyopathies, Department of Medicine III, University of Heidelberg, 69120 Heidelberg, Germany; German Centre for Cardiovascular Research (DZHK), Heidelberg/Mannheim, Germany. Electronic address:

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August 2016

The Role of Quality Control in Targeted Next-generation Sequencing Library Preparation.

Genomics Proteomics Bioinformatics 2016 08 28;14(4):200-6. Epub 2016 Jul 28.

Institute for Cardiomyopathies, Department of Internal Medicine III, University of Heidelberg, 69120 Heidelberg, Germany; German Centre for Cardiovascular Research (DZHK), Heidelberg/Mannheim, Germany. Electronic address:

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August 2016

miRNAs and sports: tracking training status and potentially confounding diagnoses.

J Transl Med 2016 07 26;14(1):219. Epub 2016 Jul 26.

Chair for Clinical Bioinformatics, Medical Department, Saarland University, Building E2.1, 66125, Saarbrücken, Germany.

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July 2016

MiRTargetLink--miRNAs, Genes and Interaction Networks.

Int J Mol Sci 2016 Apr 14;17(4):564. Epub 2016 Apr 14.

Chair for Clinical Bioinformatics, Saarland University, Saarbrücken D-66041, Germany.

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April 2016

Essential light chain S195 phosphorylation is required for cardiac adaptation under physical stress.

Cardiovasc Res 2016 07 24;111(1):44-55. Epub 2016 Mar 24.

Department of Medicine III, Cardiology, University Hospital of Heidelberg, 69120 Heidelberg, Germany DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120 Heidelberg, Germany

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July 2016

Distribution of miRNA expression across human tissues.

Nucleic Acids Res 2016 05 25;44(8):3865-77. Epub 2016 Feb 25.

Chair for Clinical Bioinformatics, Saarland University, Saarbruecken, Germany

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May 2016

Long noncoding RNA MALAT1-derived mascRNA is involved in cardiovascular innate immunity.

J Mol Cell Biol 2016 04 27;8(2):178-81. Epub 2016 Jan 27.

Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Berlin, Germany Berlin Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Berlin, Germany German Center for Cardiovascular Research (DZHK), Site Berlin, Germany

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April 2016

Bias in High-Throughput Analysis of miRNAs and Implications for Biomarker Studies.

Anal Chem 2016 Feb 27;88(4):2088-95. Epub 2016 Jan 27.

Chair for Clinical Bioinformatics, Saarland University , 66123 Saarbrücken, Germany.

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February 2016

From Single Variants to Protein Cascades: MULTISCALE MODELING OF SINGLE NUCLEOTIDE VARIANT SETS IN GENETIC DISORDERS.

J Biol Chem 2016 Jan 24;291(4):1582-90. Epub 2015 Nov 24.

From the Chair for Clinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany.

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January 2016

Pathway-based variant enrichment analysis on the example of dilated cardiomyopathy.

Hum Genet 2016 Jan 7;135(1):31-40. Epub 2015 Nov 7.

Chair for Clinical Bioinformatics, Saarland University, Building E2.1, 66123, Saarbrücken, Germany.

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January 2016

Biomarker changes after strenuous exercise can mimic pulmonary embolism and cardiac injury--a metaanalysis of 45 studies.

Clin Chem 2015 Oct 3;61(10):1246-55. Epub 2015 Aug 3.

Department of Medicine III, University of Heidelberg, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), Germany;

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October 2015

Determined to Fail--the Role of Genetic Mechanisms in Heart Failure.

Curr Heart Fail Rep 2015 Oct;12(5):333-8

Institute for Cardiomyopathies Heidelberg (ICH), Department of Internal Medicine III, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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October 2015

Towards Personalized Cardiology: Multi-Scale Modeling of the Failing Heart.

PLoS One 2015 31;10(7):e0134869. Epub 2015 Jul 31.

Department of Medicine III, University of Heidelberg, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), Heidelberg, Germany; Klaus Tschira Institute for Computational Cardiology, Heidelberg, Germany.

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April 2016

So rare we need to hunt for them: reframing the ethical debate on incidental findings.

Genome Med 2015 30;7(1):83. Epub 2015 Jul 30.

Department of Medical Oncology, Program for Ethics and Patient Oriented Care, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, 69120 Heidelberg, Germany.

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August 2015

miFRame: analysis and visualization of miRNA sequencing data in neurological disorders.

J Transl Med 2015 Jul 14;13:224. Epub 2015 Jul 14.

Chair for Clinical Computational Biology, Saarland University, Saarbrücken, Germany.

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July 2015

Involvement of BAG3 and HSPB7 loci in various etiologies of systolic heart failure: Results of a European collaboration assembling more than 2000 patients.

Int J Cardiol 2015 1;189:105-7. Epub 2015 Apr 1.

INSERM, UMR_S 1166, F-75013 Paris, France; ICAN Institute for Cardiometabolism and Nutrition, F-75013 Paris, France; Hôpital Ambroise Paré AP-HP, Paris, France; Université de Versailles Saint Quentin en Yvelines, Versailles, France.

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April 2016

The symptom complex of familial sinus node dysfunction and myocardial noncompaction is associated with mutations in the HCN4 channel.

J Am Coll Cardiol 2014 Aug;64(8):757-67

Department of Cardiology, University of Heidelberg, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, University of Heidelberg, Heidelberg, Germany. Electronic address:

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August 2014

Targeted next-generation sequencing: the clinician's stethoscope for genetic disorders.

Per Med 2014 Aug;11(6):581-592

Department of Internal Medicine III, University of Heidelberg, Heidelberg, Germany.

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August 2014