Benjamin L Ebert

Benjamin L Ebert

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Benjamin L Ebert

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CHIPing away at breast cancer.

J Natl Cancer Inst 2019 Aug 27. Epub 2019 Aug 27.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.

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http://dx.doi.org/10.1093/jnci/djz158DOI Listing
August 2019

Engineered Bcor mutations lead to acute leukemia of progenitor B-1 lymphocyte origin in a sensitized background.

Blood 2019 Jun 16;133(24):2610-2614. Epub 2019 Apr 16.

Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; and.

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http://dx.doi.org/10.1182/blood.2018864173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566592PMC
June 2019

Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription.

Cell Chem Biol 2019 May 14;26(5):711-723.e14. Epub 2019 Mar 14.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; MIT Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.02.009DOI Listing
May 2019

Impaired human hematopoiesis due to a cryptic intronic splicing mutation.

J Exp Med 2019 May 26;216(5):1050-1060. Epub 2019 Mar 26.

Division of Hematology/Oncology, The Manton Center for Orphan Disease Research, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

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http://www.jem.org/lookup/doi/10.1084/jem.20181625
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http://dx.doi.org/10.1084/jem.20181625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504223PMC
May 2019

Clonal Hematopoiesis of Indeterminate Potential.

J Clin Oncol 2019 Feb 27;37(5):419-422. Epub 2018 Dec 27.

1 Dana-Farber Cancer Institute, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2018.79.3588DOI Listing
February 2019

CHIPping Away at the Pathogenesis of Heart Failure.

JAMA Cardiol 2019 Jan;4(1):5-6

Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamacardio.2018.4039DOI Listing
January 2019

CHIP, CCUS, and Other Acronyms: Definition, Implications, and Impact on Practice.

Am Soc Clin Oncol Educ Book 2019 Jan 17;39:400-410. Epub 2019 May 17.

3 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.

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https://ascopubs.org/doi/10.1200/EDBK_239083
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http://dx.doi.org/10.1200/EDBK_239083DOI Listing
January 2019

Inhibition of Casein Kinase 1 Alpha in Acute Myeloid Leukemia.

N Engl J Med 2018 11;379(19):1873-1874

From the Dana-Farber Cancer Institute, Boston (B.L.E.); and the Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany (J.K.).

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http://dx.doi.org/10.1056/NEJMcibr1811318DOI Listing
November 2018

Jak-ing Up the Plaque's Lipid Core…and Even More.

Circ Res 2018 11;123(11):1180-1182

Brigham and Women's Hospital, and Dana Farber Cancer Institute (B.L.E.), Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309975PMC
November 2018

Generations of physician-scientists.

Authors:
Benjamin L Ebert

J Clin Invest 2018 10 1;128(10):4208-4212. Epub 2018 Oct 1.

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http://dx.doi.org/10.1172/JCI124786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159982PMC
October 2018

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.

Cancer Cell 2018 08;34(2):225-241.e8

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, Zuckerman 701, 408 East 69(th) Street, New York, NY 10065, USA; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373472PMC
August 2018

CHIP (Clonal Hematopoiesis of Indeterminate Potential).

Circulation 2018 08;138(7):666-668

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA (B.L.E.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.034392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277144PMC
August 2018

A decade of progress in myelodysplastic syndrome with chromosome 5q deletion.

Leukemia 2018 07 30;32(7):1493-1499. Epub 2018 Jan 30.

Hôpital Saint Louis, Assistance Publique-Hôpitaux de Paris Université Paris 7, Paris, France.

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http://www.nature.com/articles/s41375-018-0029-9
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http://dx.doi.org/10.1038/s41375-018-0029-9DOI Listing
July 2018

Clonal Hematopoiesis Confers Predisposition to Both Cardiovascular Disease and Cancer: A Newly Recognized Link Between Two Major Killers.

Ann Intern Med 2018 07 29;169(2):116-117. Epub 2018 May 29.

Brigham and Women's Hospital, Boston, Massachusetts (P.L.).

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http://annals.org/article.aspx?doi=10.7326/M18-0737
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http://dx.doi.org/10.7326/M18-0737DOI Listing
July 2018

Predicting progression to AML.

Nat Med 2018 07;24(7):904-906

Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41591-018-0114-7DOI Listing
July 2018

Clonal Hematopoiesis after Induction Chemotherapy for Acute Myeloid Leukemia.

N Engl J Med 2018 03;378(13):1244-1245

From the Dana-Farber Cancer Institute and Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMe1802610DOI Listing
March 2018

Utility of CRISPR/Cas9 systems in hematology research.

Exp Hematol 2017 10 28;54:1-3. Epub 2017 Jun 28.

Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2017.06.006DOI Listing
October 2017

Clonal Hematopoiesis and Atherosclerosis.

N Engl J Med 2017 10;377(14):1401-1402

Brigham and Women’s Hospital, Boston, MA

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http://dx.doi.org/10.1056/NEJMc1710381DOI Listing
October 2017

Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia.

Cell Stem Cell 2017 10;21(4):547-555.e8

Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA; Division of Hematology, Brigham and Women's Hospital, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679060PMC
October 2017

Leukaemia: Vitamin C regulates stem cells and cancer.

Nature 2017 09 6;549(7673):462-464. Epub 2017 Sep 6.

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA, in the Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, and at the Broad Institute of MIT and Harvard, Cambridge, Massachusetts.

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http://dx.doi.org/10.1038/nature23548DOI Listing
September 2017

Prevalent premalignancy.

Blood 2017 08;130(6):695-696

DANA-FARBER CANCER INSTITUTE.

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http://dx.doi.org/10.1182/blood-2017-05-786210DOI Listing
August 2017

Introduction to a review series on precision hematology.

Authors:
Benjamin L Ebert

Blood 2017 07 9;130(4):408-409. Epub 2017 Jun 9.

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1182/blood-2017-06-735753DOI Listing
July 2017

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease.

N Engl J Med 2017 07 21;377(2):111-121. Epub 2017 Jun 21.

From the Department of Medicine, Division of Hematology, Brigham and Women's Hospital (S.J., A.J.S., M.M.) and Harvard Medical School (B.L.E.), the Department of Medicine, Division of Cardiovascular Medicine, Brigham and Women's Hospital (E.S.) and Harvard Medical School (G.K.S., P.L.), the Department of Pathology (S.J.) and the Center for Genomic Medicine (P.N., S.K.), Massachusetts General Hospital, the Department of Medicine, Division of Cardiology, and Cardiovascular Research Center (P.N., S.K.), and the Department of Medicine (A.G.B.), Massachusetts General Hospital and Harvard Medical School, and the Departments of Medical Oncology (C.J.G.) and Biostatistics and Computational Biology (D.N.), Dana-Farber Cancer Institute, Boston, and the Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge (P.N., A.G.B., N.G., S.G., S.K.) - all in Massachusetts; the Department of Cardiology, University Hospital, Parma, Italy (D.A.); the Department of Medicine, Division of Cardiology, Mt. Sinai School of Medicine, New York (U.B., R.M., V.F.); Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid (V.F.); Medical Research Council-British Heart Foundation Cardiovascular Epidemiology Unit and National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, and the British Heart Foundation, Cambridge Centre of Excellence, Department of Medicine, University of Cambridge, Cambridge (J.D.), and the Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton (J.D.) - both in the United Kingdom; the Center for Non-Communicable Diseases, Karachi, Pakistan (P.F., D.S.); the Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia (D.S.); and the Department of Clinical Sciences Malmö, Lund University, Lund, Sweden (O.M.).

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http://dx.doi.org/10.1056/NEJMoa1701719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717509PMC
July 2017

Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma.

J Clin Oncol 2017 May 9;35(14):1598-1605. Epub 2017 Jan 9.

Christopher J. Gibson, R. Coleman Lindsley, Brenton G. Mar, Jiantao Shi, Ann S. Lacasce, Arnold S. Freedman, David C. Fisher, Eric Jacobsen, Philippe Armand, Edwin P. Alyea, John Koreth, Vincent Ho, Robert J. Soiffer, Joseph H. Antin, Jerome Ritz, Sarah Nikiforow, Franziska Michor, and Donna Neuberg, Dana-Farber Cancer Institute; Jiantao Shi and Franziska Michor, Harvard T.H. Chan School of Public Health; Siddhartha Jaiswal, Elizabeth A. Morgan, and Benjamin L. Ebert, Brigham and Women's Hospital, Boston; Benjamin L. Ebert, Broad Institute, Cambridge, MA; Vatche Tchekmedyian, Memorial Sloan Kettering Cancer Center, New York, NY; Alysia Bosworth, Anita Bansal, and Stephen J. Forman, City of Hope National Medical Center, Duarte, CA; and Liton Francisco, Jianbo He, Ravi Bhatia, and Smita Bhatia, University of Alabama at Birmingham, Birmingham, AL.

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http://dx.doi.org/10.1200/JCO.2016.71.6712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455707PMC
May 2017

Clinical Implications of Genetic Mutations in Myelodysplastic Syndrome.

J Clin Oncol 2017 Mar 13;35(9):968-974. Epub 2017 Feb 13.

James A. Kennedy, University Health Network, Toronto, Ontario, Canada; James A. Kennedy and Benjamin L. Ebert, Brigham and Women's Hospital; and Benjamin L. Ebert, Dana-Farber Cancer Institute, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2016.71.0806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455680PMC
March 2017

Introduction to Genomics in Hematologic Malignancy.

J Clin Oncol 2017 03 13;35(9):927-928. Epub 2017 Feb 13.

Benjamin L. Ebert, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; and Jonathan W. Friedberg, University of Rochester Wilmot Cancer Institute, Rochester, NY.

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http://dx.doi.org/10.1200/JCO.2017.72.2827DOI Listing
March 2017

Prognostic Mutations in Myelodysplastic Syndrome after Stem-Cell Transplantation.

N Engl J Med 2017 02;376(6):536-547

From the Department of Medical Oncology, Division of Hematological Malignancies (R.C.L., C.C., J.H.A.), and the Departments of Pediatric Oncology (B.G.M.) and Biostatistics and Computational Biology (R.R., D.N.), Dana-Farber Cancer Institute, and the Division of Hematology, Brigham and Women's Hospital, Harvard Medical School (P.V.G., B.L.E.) - all in Boston; the Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee (W.S., T.W., Z.-H.H., S.J.L.); the Center for International Blood and Marrow Transplant Research, National Marrow Donor Program-Be the Match (M.D.H., S.R.S.), and the Pediatric Blood and Marrow Transplantation Center, University of Minnesota (M.R.V.) - both in Minneapolis; the Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle (S.J.L.); Memorial Sloan Kettering Cancer Center, New York (K.H.); and the Institute for Experimental Cellular Therapy, University Hospital Essen, Essen, Germany (K.F.).

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http://dx.doi.org/10.1056/NEJMoa1611604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438571PMC
February 2017

Doubling Down on Mutant RAS Can MEK or Break Leukemia.

Cell 2017 02;168(5):749-750

Brigham and Women's Hospital, Division of Hematology, Boston, MA 02115, USA; Dana Farber Cancer Institute, Department of Medical Oncology, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.02.013DOI Listing
February 2017

The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemia.

Nat Rev Cancer 2017 01 11;17(1):5-19. Epub 2016 Nov 11.

Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://www.nature.com/articles/nrc.2016.112
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http://dx.doi.org/10.1038/nrc.2016.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470392PMC
January 2017

Clonal hematopoiesis.

Semin Hematol 2017 01 20;54(1):43-50. Epub 2016 Oct 20.

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. Electronic address:

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http://dx.doi.org/10.1053/j.seminhematol.2016.10.002DOI Listing
January 2017

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 07 11;30(1):183. Epub 2016 Jul 11.

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http://dx.doi.org/10.1016/j.ccell.2016.06.008DOI Listing
July 2016

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.

Cell 2016 Apr;165(2):303-16

Department of Medicine, Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard University and MIT, Cambridge, MA 02142, USA; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826477PMC
April 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 04;29(4):574-586

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, 450 Brookline Avenue, Dana 510B, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177991PMC
April 2016

Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells.

Genome Res 2015 Dec 1;25(12):1860-72. Epub 2015 Oct 1.

Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02140, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02140, USA.

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http://dx.doi.org/10.1101/gr.192237.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665007PMC
December 2015

Lenalidomide: deciphering mechanisms of action in myeloma, myelodysplastic syndrome and beyond.

Curr Opin Cell Biol 2015 Dec 11;37:61-7. Epub 2015 Nov 11.

Brigham and Women's Hospital, Division of Hematology, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2015.10.004DOI Listing
December 2015

DMSO Increases Mutation Scanning Detection Sensitivity of High-Resolution Melting in Clinical Samples.

Clin Chem 2015 Nov 2;61(11):1354-62. Epub 2015 Oct 2.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA;

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http://dx.doi.org/10.1373/clinchem.2015.245357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156568PMC
November 2015

The novel mechanism of lenalidomide activity.

Blood 2015 Nov 5;126(21):2366-9. Epub 2015 Oct 5.

Brigham and Women's Hospital, Division of Hematology, Boston, MA.

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http://dx.doi.org/10.1182/blood-2015-07-567958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653765PMC
November 2015

EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression.

Blood 2015 Oct 28;126(16):1930-9. Epub 2015 Aug 28.

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA;

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http://dx.doi.org/10.1182/blood-2015-06-649087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608240PMC
October 2015

Inactivation of HDAC1 or HDAC2 induces gamma globin expression without altering cell cycle or proliferation.

Am J Hematol 2015 Jul 28;90(7):624-8. Epub 2015 May 28.

Harvard Medical School, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1002/ajh.24019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909492PMC
July 2015

Phase 1/2 trial of vorinostat in patients with sickle cell disease who have not benefitted from hydroxyurea.

Blood 2015 Jun;125(23):3668-9

Division of Hematology, Brigham and Women's Hospital, Boston, MA Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2015-03-63
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http://dx.doi.org/10.1182/blood-2015-03-635391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458806PMC
June 2015

Charting the "Splice" Routes to MDS.

Cancer Cell 2015 May;27(5):607-9

Division of Hematology, Brigham and Women's Hospital, Boston, MA 02115, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108150014
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http://dx.doi.org/10.1016/j.ccell.2015.04.016DOI Listing
May 2015

Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms.

Blood 2015 Jan 3;125(2):327-35. Epub 2014 Oct 3.

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Broad Institute, Cambridge, MA.

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http://dx.doi.org/10.1182/blood-2014-04-567024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287639PMC
January 2015

Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis.

Cell Stem Cell 2015 Jan 20;16(1):51-66. Epub 2014 Nov 20.

Renal Division, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289444PMC
January 2015

L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-independent way.

Br J Haematol 2014 Nov 7;167(4):524-528. Epub 2014 Aug 7.

Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Karp 5-2117, 1 Blackfan Circle, Boston, MA, 02115.

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http://dx.doi.org/10.1111/bjh.13069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211992PMC
November 2014

TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients.

Blood 2014 Oct 15;124(17):2705-12. Epub 2014 Sep 15.

Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA; and.

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http://dx.doi.org/10.1182/blood-2014-06-582809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208285PMC
October 2014

Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS.

Cancer Cell 2014 Oct 18;26(4):509-20. Epub 2014 Sep 18.

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199102PMC
October 2014

Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing.

Nat Biotechnol 2014 Sep 22;32(9):941-6. Epub 2014 Jun 22.

1] Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. [2] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.2951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160386PMC
September 2014

Somatic mutations predict poor outcome in patients with myelodysplastic syndrome after hematopoietic stem-cell transplantation.

J Clin Oncol 2014 Sep 4;32(25):2691-8. Epub 2014 Aug 4.

Rafael Bejar and Bennett Caughey, University of California at San Diego, La Jolla, CA; Kristen E. Stevenson, R. Coleman Lindsley, Brenton G. Mar, David P. Steensma, Jerome Ritz, Robert Soiffer, Joseph H. Antin, Edwin Alyea, Philippe Armand, Vincent Ho, John Koreth, Donna Neuberg, and Corey S. Cutler, Dana-Farber Cancer Institute; R. Coleman Lindsley and Benjamin L. Ebert, Brigham and Women's Hospital, Harvard Medical School, Boston; Petar Stojanov, Gad Getz, and Benjamin L. Ebert, Broad Institute, Cambridge, MA.

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http://dx.doi.org/10.1200/JCO.2013.52.3381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207878PMC
September 2014

National trends in hospitalizations for sickle cell disease in the United States following the FDA approval of hydroxyurea, 1998-2008.

Med Care 2014 Jul;52(7):612-8

*Department of Medicine, Division of Hematology †Department of Medicine, Division of General Medicine and Primary Care, Brigham and Women's Hospital ‡Department of Health Care Policy, Harvard Medical School, Boston, MA §Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, MI.

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http://dx.doi.org/10.1097/MLR.0000000000000143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177169PMC
July 2014

Lenalidomide induces degradation of IKZF1 and IKZF3.

Oncoimmunology 2014;3(7):e941742. Epub 2014 Jul 3.

Brigham and Women's Hospital ; Boston, MA USA.

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http://dx.doi.org/10.4161/21624011.2014.941742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292522PMC
July 2014

MDS is a stem cell disorder after all.

Cancer Cell 2014 Jun;25(6):713-4

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108140023
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http://dx.doi.org/10.1016/j.ccr.2014.06.001DOI Listing
June 2014