Publications by authors named "Benjamin J Blencowe"

100Publications

Microexons: at the nexus of nervous system development, behaviour and autism spectrum disorder.

Curr Opin Genet Dev 2020 Jun 11;65:22-33. Epub 2020 Jun 11.

Donnelly Centre, University of Toronto, Toronto, ON, M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2020.03.007DOI Listing
June 2020

A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum.

Cell Rep 2020 Jun;31(9):107703

Fondazione Santa Lucia, IRCCS, Rome, Italy; Department of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Heart, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.107703DOI Listing
June 2020

Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome.

Cell Rep 2020 03;30(12):4179-4196.e11

Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.02.107DOI Listing
March 2020

Alternative Splicing Regulatory Networks: Functions, Mechanisms, and Evolution.

Mol Cell 2019 10;76(2):329-345

Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 3E1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.09.017DOI Listing
October 2019

Neuronal-specific microexon splicing of mRNA is directly regulated by SRRM4/nSR100.

RNA Biol 2020 01 27;17(1):62-74. Epub 2019 Sep 27.

German Cancer Consortium (DKTK) partner site Freiburg, German Cancer Research Center (DKFZ) and Department of Urology, Medical Center-University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1080/15476286.2019.1667214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948980PMC
January 2020

Differential contribution of steady-state RNA and active transcription in chromatin organization.

EMBO Rep 2019 10 26;20(10):e48068. Epub 2019 Aug 26.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.

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http://dx.doi.org/10.15252/embr.201948068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776903PMC
October 2019

The Long Noncoding RNA Pnky Is a Trans-acting Regulator of Cortical Development In Vivo.

Dev Cell 2019 05;49(4):632-642.e7

Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2019.04.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556063PMC
May 2019

Autism spectrum disorder: insights into convergent mechanisms from transcriptomics.

Nat Rev Genet 2019 01;20(1):51-63

Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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http://www.nature.com/articles/s41576-018-0066-2
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http://dx.doi.org/10.1038/s41576-018-0066-2DOI Listing
January 2019

Efficient and Accurate Quantitative Profiling of Alternative Splicing Patterns of Any Complexity on a Laptop.

Mol Cell 2018 10 13;72(1):187-200.e6. Epub 2018 Sep 13.

Donnelly Centre, University of Toronto, Toronto M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto M5S 3E1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.08.018DOI Listing
October 2018

Author Correction: Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism.

Nature 2018 08;560(7718):E30

Center for Autism Research and Treatment and Program in Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, 90095, USA.

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http://dx.doi.org/10.1038/s41586-018-0295-8DOI Listing
August 2018

Orchestrating Ribosomal Subunit Coordination to Control Stem Cell Fate.

Cell Stem Cell 2018 04;22(4):471-473

Donnelly Centre and Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.03.019DOI Listing
April 2018

QAPA: a new method for the systematic analysis of alternative polyadenylation from RNA-seq data.

Genome Biol 2018 03 28;19(1):45. Epub 2018 Mar 28.

Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, ON, M5A 1A8, Canada.

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http://dx.doi.org/10.1186/s13059-018-1414-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874996PMC
March 2018

Regulatory Expansion in Mammals of Multivalent hnRNP Assemblies that Globally Control Alternative Splicing.

Cell 2017 Jul;170(2):324-339.e23

Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.06.037DOI Listing
July 2017

The Relationship between Alternative Splicing and Proteomic Complexity.

Trends Biochem Sci 2017 06 5;42(6):407-408. Epub 2017 May 5.

Donnelly Centre and Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, ONT, M5S 3E1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2017.04.001DOI Listing
June 2017

Major Roles for Pyrimidine Dimers, Nucleotide Excision Repair, and ATR in the Alternative Splicing Response to UV Irradiation.

Cell Rep 2017 03;18(12):2868-2879

Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-UBA-CONICET) and Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.02.066DOI Listing
March 2017

LUMIER: A Discovery Tool for Mammalian Protein Interaction Networks.

Methods Mol Biol 2017 ;1550:137-148

Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, Canada, M5G 1X5.

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http://dx.doi.org/10.1007/978-1-4939-6747-6_11DOI Listing
February 2018

Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders.

Mol Cell 2016 12;64(6):1023-1034

Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.11.033DOI Listing
December 2016

Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism.

Nature 2016 12 5;540(7633):423-427. Epub 2016 Dec 5.

Center for Autism Research and Treatment and Program in Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1038/nature20612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102905PMC
December 2016

The ribosome-engaged landscape of alternative splicing.

Nat Struct Mol Biol 2016 Dec 7;23(12):1117-1123. Epub 2016 Nov 7.

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nsmb.3317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295628PMC
December 2016

MECP2 Is Post-transcriptionally Regulated during Human Neurodevelopment by Combinatorial Action of RNA-Binding Proteins and miRNAs.

Cell Rep 2016 10;17(3):720-734

Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.09.049DOI Listing
October 2016

Conserved functional antagonism of CELF and MBNL proteins controls stem cell-specific alternative splicing in planarians.

Elife 2016 08 9;5. Epub 2016 Aug 9.

Systems Biology of Gene Regulatory Elements, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin, Germany.

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http://dx.doi.org/10.7554/eLife.16797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978528PMC
August 2016

The RNA-binding profile of Acinus, a peripheral component of the exon junction complex, reveals its role in splicing regulation.

RNA 2016 09 30;22(9):1411-26. Epub 2016 Jun 30.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom.

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http://dx.doi.org/10.1261/rna.057158.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986896PMC
September 2016

Global Mapping of Human RNA-RNA Interactions.

Mol Cell 2016 05 12;62(4):618-26. Epub 2016 May 12.

Donnelly Centre, University of Toronto, Toronto, ON M53 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M53 3E1, Canada. Electronic address:

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http://www.cell.com/molecular-cell/pdf/S1097-2765(16)30106-X
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http://linkinghub.elsevier.com/retrieve/pii/S109727651630106
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http://dx.doi.org/10.1016/j.molcel.2016.04.030DOI Listing
May 2016

Sequence evidence for common ancestry of eukaryotic endomembrane coatomers.

Sci Rep 2016 Mar 2;6:22311. Epub 2016 Mar 2.

Bioinformatics Research Laboratory, Department of Biological Sciences, New Campus, University of Cyprus, PO Box 20537, CY-1678 Nicosia, Cyprus.

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http://dx.doi.org/10.1038/srep22311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773986PMC
March 2016

An alternative splicing event amplifies evolutionary differences between vertebrates.

Science 2015 Aug;349(6250):868-73

Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada. Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1126/science.aaa8381DOI Listing
August 2015

Alternative Splicing in the Mammalian Nervous System: Recent Insights into Mechanisms and Functional Roles.

Neuron 2015 Jul;87(1):14-27

Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://www.cell.com/neuron/pdf/S0896-6273(15)00411-0.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S089662731500411
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http://dx.doi.org/10.1016/j.neuron.2015.05.004DOI Listing
July 2015

A germline mutation in SRRM2, a splicing factor gene, is implicated in papillary thyroid carcinoma predisposition.

Sci Rep 2015 Jul 2;5:10566. Epub 2015 Jul 2.

Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America.

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http://dx.doi.org/10.1038/srep10566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488885PMC
July 2015

Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool.

Development 2015 Aug 26;142(15):2564-73. Epub 2015 Jun 26.

Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8 Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada M5G 1X5

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http://dx.doi.org/10.1242/dev.122648DOI Listing
August 2015

Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming.

Genes Dev 2015 Apr 15;29(8):803-16. Epub 2015 Apr 15.

Center for Cancer Epigenetics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Smithville, Texas 78957, USA;

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http://dx.doi.org/10.1101/gad.255109.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403257PMC
April 2015

Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.

Genes Dev 2015 Apr;29(7):746-59

Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada; Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada;

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http://dx.doi.org/10.1101/gad.256115.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387716PMC
April 2015

Reflections for the 20th anniversary issue of RNA journal.

RNA 2015 Apr;21(4):573-5

Donnelly Centre and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 3E1

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http://dx.doi.org/10.1261/rna.051003.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371286PMC
April 2015

RNA splicing. The human splicing code reveals new insights into the genetic determinants of disease.

Science 2015 Jan 18;347(6218):1254806. Epub 2014 Dec 18.

Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario M5S 3G4, Canada. Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada. Program on Genetic Networks and Program on Neural Computation & Adaptive Perception, Canadian Institute for Advanced Research, Toronto, Ontario M5G 1Z8, Canada. Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada. McLaughlin Centre, University of Toronto, Toronto, Ontario M5G 0A4, Canada. Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada. eScience Group, Microsoft Research, Redmond, WA 98052, USA.

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http://dx.doi.org/10.1126/science.1254806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362528PMC
January 2015

Widespread intron retention in mammals functionally tunes transcriptomes.

Genome Res 2014 Nov 25;24(11):1774-86. Epub 2014 Sep 25.

Donnelly Centre, University of Toronto, Ontario, M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Ontario, M5S 1A8, Canada;

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http://dx.doi.org/10.1101/gr.177790.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216919PMC
November 2014

A global regulatory mechanism for activating an exon network required for neurogenesis.

Mol Cell 2014 Oct 11;56(1):90-103. Epub 2014 Sep 11.

Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608043PMC
October 2014

Next-generation RNA sequencing of archival formalin-fixed paraffin-embedded urothelial bladder cancer.

Eur Urol 2014 Dec 6;66(6):982-6. Epub 2014 Sep 6.

The Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2014.07.045DOI Listing
December 2014

Epstein-Barr virus EBNA1 protein regulates viral latency through effects on let-7 microRNA and dicer.

J Virol 2014 Oct 16;88(19):11166-77. Epub 2014 Jul 16.

Department of Molecular Genetics, University of Toronto, Toronto, Canada

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http://dx.doi.org/10.1128/JVI.01785-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178782PMC
October 2014

Brain-expressed exons under purifying selection are enriched for de novo mutations in autism spectrum disorder.

Nat Genet 2014 Jul 25;46(7):742-7. Epub 2014 May 25.

1] The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada. [2] McLaughlin Centre, University of Toronto, Toronto, Ontario, Canada. [3] Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ng.2980DOI Listing
July 2014

Functional genomics evidence unearths new moonlighting roles of outer ring coat nucleoporins.

Sci Rep 2014 Apr 11;4:4655. Epub 2014 Apr 11.

1] Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada [2] Bioinformatics Research Laboratory, Department of Biological Sciences, University of Cyprus, PO Box 20537, CY-1678 Nicosia, Cyprus [3] Institute of Applied Biosciences, Centre for Research & Technology, PO Box 361, GR-57001 Thessalonica, Greece [4].

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http://www.nature.com/articles/srep04655
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http://dx.doi.org/10.1038/srep04655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983603PMC
April 2014

Regulated aggregative multicellularity in a close unicellular relative of metazoa.

Elife 2013 Dec 24;2:e01287. Epub 2013 Dec 24.

Department of Functional Genomics and Evolution, Institut de Biologia Evolutiva (CSIC-Universitat Pompeu Fabra), Barcelona, Spain.

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http://dx.doi.org/10.7554/eLife.01287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870316PMC
December 2013

Dynamic integration of splicing within gene regulatory pathways.

Cell 2013 Mar;152(6):1252-69

Banting and Best Department of Medical Research, Donnelly Centre, University of Toronto, Toronto, ON M5S 1A8, Canada.

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http://dx.doi.org/10.1016/j.cell.2013.02.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642998PMC
March 2013

An exon-centric perspective.

Biochem Cell Biol 2012 Oct 11;90(5):603-12. Epub 2012 Jul 11.

Banting and Best Department of Medical Research and Department of Molecular Genetics, Donnelly Centre, University of Toronto, 160 College Street, Room 1016, Toronto, ON M5S 3E1, Canada.

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http://dx.doi.org/10.1139/o2012-019DOI Listing
October 2012

Tissue-specific alternative splicing remodels protein-protein interaction networks.

Mol Cell 2012 Jun;46(6):884-92

Banting and Best Department of Medical Research, Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.

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http://dx.doi.org/10.1016/j.molcel.2012.05.037DOI Listing
June 2012

Alternative splicing: decoding an expansive regulatory layer.

Curr Opin Cell Biol 2012 Jun 30;24(3):323-32. Epub 2012 Mar 30.

Banting and Best Department of Medical Research, Donnelly Centre, University of Toronto, Canada.

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http://dx.doi.org/10.1016/j.ceb.2012.03.005DOI Listing
June 2012

Alternative splicing networks regulated by signaling in human T cells.

RNA 2012 May 27;18(5):1029-40. Epub 2012 Mar 27.

Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6059, USA.

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http://dx.doi.org/10.1261/rna.032243.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334690PMC
May 2012

SnapShot: High-throughput sequencing applications.

Cell 2011 Sep;146(6):1044, 1044.e1-2

Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5S 3E1, Canada.

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http://dx.doi.org/10.1016/j.cell.2011.09.002DOI Listing
September 2011

Cross-regulation between an alternative splicing activator and a transcription repressor controls neurogenesis.

Mol Cell 2011 Sep;43(5):843-50

Banting and Best Department of Medical Research, Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

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http://dx.doi.org/10.1016/j.molcel.2011.08.014DOI Listing
September 2011

Transcriptomic analysis of autistic brain reveals convergent molecular pathology.

Nature 2011 May 25;474(7351):380-4. Epub 2011 May 25.

Program in Neurogenetics and Neurobehavioral Genetics, Department of Neurology and Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, California 90095-1769, USA.

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http://www.nature.com/articles/nature10110
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http://dx.doi.org/10.1038/nature10110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607626PMC
May 2011

Networking in a global world: establishing functional connections between neural splicing regulators and their target transcripts.

RNA 2011 May 17;17(5):775-91. Epub 2011 Mar 17.

Banting and Best Department of Medical Research, Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1261/rna.2603911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078728PMC
May 2011

Regulation of alternative splicing by the core spliceosomal machinery.

Genes Dev 2011 Feb;25(4):373-84

Banting and Best Department of Medical Research, The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

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http://dx.doi.org/10.1101/gad.2004811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042160PMC
February 2011

Genome-wide analysis of alternative splicing in Caenorhabditis elegans.

Genome Res 2011 Feb 22;21(2):342-8. Epub 2010 Dec 22.

Banting and Best Department of Medical Research, Donnelly Centre, University of Toronto, Ontario M5S 3E1, Canada.

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http://dx.doi.org/10.1101/gr.114645.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032936PMC
February 2011

Global impact of RNA polymerase II elongation inhibition on alternative splicing regulation.

Genome Res 2011 Mar 16;21(3):390-401. Epub 2010 Dec 16.

Banting and Best Department of Medical Research, Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

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http://dx.doi.org/10.1101/gr.111070.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044853PMC
March 2011

Global profiling and molecular characterization of alternative splicing events misregulated in lung cancer.

Mol Cell Biol 2011 Jan 1;31(1):138-50. Epub 2010 Nov 1.

Banting and Best Department of Medical Research, University of Toronto, Donnelly Centre, 160 College Street, Toronto, Ontario, Canada M5S 3E1.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.00709-10
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http://dx.doi.org/10.1128/MCB.00709-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019846PMC
January 2011

Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay.

Proc Natl Acad Sci U S A 2010 Jul 21;107(27):12186-91. Epub 2010 Jun 21.

Campbell Family Cancer Research Institute and Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1073/pnas.1007336107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901484PMC
July 2010

Most "dark matter" transcripts are associated with known genes.

PLoS Biol 2010 May 18;8(5):e1000371. Epub 2010 May 18.

Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1371/journal.pbio.1000371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872640PMC
May 2010

Deciphering the splicing code.

Nature 2010 May;465(7294):53-9

Biomedical Engineering, Department of Electrical and Computer Engineering, University of Toronto, 10 King's College Road, Toronto M5S 3G4, Canada.

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http://dx.doi.org/10.1038/nature09000DOI Listing
May 2010

A systematic characterization of Cwc21, the yeast ortholog of the human spliceosomal protein SRm300.

RNA 2009 Dec 29;15(12):2174-85. Epub 2009 Sep 29.

Banting and Best Department of Medical Research, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

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http://dx.doi.org/10.1261/rna.1790509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779666PMC
December 2009

When chromatin meets splicing.

Nat Struct Mol Biol 2009 Sep;16(9):902-3

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http://dx.doi.org/10.1038/nsmb0909-902DOI Listing
September 2009

Regulation of vertebrate nervous system alternative splicing and development by an SR-related protein.

Cell 2009 Sep;138(5):898-910

Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S009286740900711
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http://dx.doi.org/10.1016/j.cell.2009.06.012DOI Listing
September 2009

Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins.

Nat Biotechnol 2009 Jul 28;27(7):667-70. Epub 2009 Jun 28.

Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nbt.1550DOI Listing
July 2009

Current-generation high-throughput sequencing: deepening insights into mammalian transcriptomes.

Genes Dev 2009 Jun;23(12):1379-86

Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

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http://dx.doi.org/10.1101/gad.1788009DOI Listing
June 2009

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing.

Nat Genet 2008 Dec 2;40(12):1413-5. Epub 2008 Nov 2.

Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1038/ng.259DOI Listing
December 2008

Regulation of multiple core spliceosomal proteins by alternative splicing-coupled nonsense-mediated mRNA decay.

Mol Cell Biol 2008 Jul 28;28(13):4320-30. Epub 2008 Apr 28.

Department of Molecular Genetics, Centre for Cellular and Biomolecular Research, 160 College Street, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

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http://dx.doi.org/10.1128/MCB.00361-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447145PMC
July 2008

SnapShot: The splicing regulatory machinery.

Cell 2008 Apr;133(1):192.e1

Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5S 3E1, Canada.

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http://dx.doi.org/10.1016/j.cell.2008.03.010DOI Listing
April 2008

Technologies for the global discovery and analysis of alternative splicing.

Adv Exp Med Biol 2007 ;623:64-84

Banting and Best Department of Medical Research, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1007/978-0-387-77374-2_5DOI Listing
April 2008

Using expression profiling data to identify human microRNA targets.

Nat Methods 2007 Dec 18;4(12):1045-9. Epub 2007 Nov 18.

Department of Electrical and Computer Engineering, University of Toronto, 10 King's College Road, Toronto, Ontario M5S 3G4, Canada.

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http://dx.doi.org/10.1038/nmeth1130DOI Listing
December 2007

Global analysis of alternative splicing differences between humans and chimpanzees.

Genes Dev 2007 Nov 31;21(22):2963-75. Epub 2007 Oct 31.

Banting and Best Department of Medical Research, University of Toronto, Terrence Donnelly Center for Cellular and Biomolecular Research, Toronto, Ontario M5S 3E1, Canada.

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http://dx.doi.org/10.1101/gad.1606907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2049197PMC
November 2007