Benjamin Haley

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Benjamin Haley

Publications by authors named "Benjamin Haley"

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50Publications

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A CRISPR screen identifies MAPK7 as a target for combination with MEK inhibition in KRAS mutant NSCLC.

PLoS One 2018 18;13(6):e0199264. Epub 2018 Jun 18.

Department of Discovery Oncology, Genentech Inc., South San Francisco, CA, United States of America.

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June 2018

ASC- and caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages.

Sci Rep 2018 Feb 28;8(1):3788. Epub 2018 Feb 28.

Department of Physiological Chemistry, Genentech Inc., South San Francisco, California, USA.

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February 2018

PRC2-mediated repression of SMARCA2 predicts EZH2 inhibitor activity in SWI/SNF mutant tumors.

Proc Natl Acad Sci U S A 2017 11 30;114(46):12249-12254. Epub 2017 Oct 30.

Department of Discovery Oncology, Genentech, Inc., South San Francisco, CA 94080;

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November 2017

Biological basis of radiation protection needs rejuvenation.

Int J Radiat Biol 2017 10 13;93(10):1056-1063. Epub 2017 Mar 13.

a Department of Radiation Oncology , Northwestern University , Chicago , IL , USA.

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October 2017

Expansion of the ISWI chromatin remodeler family with new active complexes.

EMBO Rep 2017 10 11;18(10):1697-1706. Epub 2017 Aug 11.

Department of Early Discovery Biochemistry, Genentech, Inc., South San Francisco, CA, USA

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October 2017

Non-canonical reader modules of BAZ1A promote recovery from DNA damage.

Nat Commun 2017 10 11;8(1):862. Epub 2017 Oct 11.

Department of Early Discovery Biochemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.

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October 2017

KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.

Cell 2017 Feb 16;168(5):817-829.e15. Epub 2017 Feb 16.

Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143, USA; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA. Electronic address:

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February 2017

Proline Starvation Induces Unresolved ER Stress and Hinders mTORC1-Dependent Tumorigenesis.

Cell Metab 2016 Nov 8;24(5):753-761. Epub 2016 Sep 8.

Department of Discovery Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:

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November 2016

Carboxypeptidase D is the only enzyme responsible for antibody C-terminal lysine cleavage in Chinese hamster ovary (CHO) cells.

Biotechnol Bioeng 2016 10 6;113(10):2100-6. Epub 2016 Apr 6.

Department of Early Stage Cell Culture, Genentech Inc., 1 DNA Way, South San Francisco, California 94080.

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October 2016

Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs.

Nat Commun 2016 Aug 3;7:12351. Epub 2016 Aug 3.

Department of Discovery Oncology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA.

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August 2016

mTORC1-Dependent Metabolic Reprogramming Underlies Escape from Glycolysis Addiction in Cancer Cells.

Cancer Cell 2016 Apr 24;29(4):548-562. Epub 2016 Mar 24.

Department of Discovery Oncology, Genentech Inc, South San Francisco, CA 94080, USA. Electronic address:

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April 2016

The Increase in Animal Mortality Risk following Exposure to Sparsely Ionizing Radiation Is Not Linear Quadratic with Dose.

PLoS One 2015 9;10(12):e0140989. Epub 2015 Dec 9.

Departments of Radiation Oncology, Radiology, and Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United States of America.

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December 2015

Requirement for BUB1B/BUBR1 in tumor progression of lung adenocarcinoma.

Genes Cancer 2015 Mar;6(3-4):106-18

Departments of Molecular Biology, Genentech Inc., South San Francisco, California, USA.

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March 2015

Comparing radiation toxicities across species: an examination of radiation effects in Mus musculus and Peromyscus leucopus.

Int J Radiat Biol 2013 Jun 4;89(6):391-400. Epub 2013 Mar 4.

Department of Radiation Oncology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.

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June 2013

The effects of radiation and dose-fractionation on cancer and non-tumor disease development.

Int J Environ Res Public Health 2012 Dec 18;9(12):4688-703. Epub 2012 Dec 18.

Department of Radiation Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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December 2012

Neural-specific elongation of 3' UTRs during Drosophila development.

Proc Natl Acad Sci U S A 2011 Sep 6;108(38):15864-9. Epub 2011 Sep 6.

Division of Genetics, Genomics, and Development, Department of Molecular and Cell Biology, Center for Integrative Genomics, University of California, Berkeley, CA 94720-3200, USA.

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September 2011

Pattern formation by a moving morphogen source.

Phys Biol 2011 Aug 12;8(4):045003. Epub 2011 Jul 12.

Department of Chemical and Biological Engineering, Lewis Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Washington Road, Princeton University, Princeton, NJ 08544, USA.

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August 2011

Past and future work on radiobiology mega-studies: a case study at Argonne National Laboratory.

Health Phys 2011 Jun;100(6):613-21

Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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June 2011

Vectors and parameters that enhance the efficacy of RNAi-mediated gene disruption in transgenic Drosophila.

Proc Natl Acad Sci U S A 2010 Jun 4;107(25):11435-40. Epub 2010 Jun 4.

Center for Integrative Genomics, Division of Genetics, Genomics, and Development, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.

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June 2010

Suprachiasmatic nucleus neurons display endogenous resistance to excitotoxicity.

Exp Biol Med (Maywood) 2010 Feb;235(2):237-46

Department of Medicine, Division of Internal Medicine and Psychiatry, Southern Illinois School of Medicine, Springfield, IL 62794-9636, USA.

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February 2010

Response of heterogeneous ribonuclear proteins (hnRNP) to ionising radiation and their involvement in DNA damage repair.

Int J Radiat Biol 2009 Aug;85(8):643-55

Department of Radiation Oncology, Northwestern University, Chicago, Illinois, USA.

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August 2009

A distinct class of small RNAs arises from pre-miRNA-proximal regions in a simple chordate.

Nat Struct Mol Biol 2009 Feb 18;16(2):183-9. Epub 2009 Jan 18.

Department of Molecular Cell Biology, Division of Genetics, Genomics, and Development, Center for Integrative Genomics, University of California, Berkeley, California 94720-3200, USA.

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February 2009

Methods for assessing DNA hybridization of peptide nucleic acid-titanium dioxide nanoconjugates.

Anal Biochem 2008 Dec 26;383(2):226-35. Epub 2008 Aug 26.

Department of Radiation Oncology, Northwestern University, Feinberg School of Medicine, 303 E. Chicago Avenue, Ward-13-002, Chicago, IL 60611, USA.

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December 2008

A simplified miRNA-based gene silencing method for Drosophila melanogaster.

Dev Biol 2008 Sep 19;321(2):482-90. Epub 2008 Jun 19.

Department of Molecular and Cell Biology, Division of Genetics, Genomics, and Development, Center for Integrative Genomics, University of California, Berkeley, Berkeley, California 94720, USA.

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September 2008

Ribo-gnome: the big world of small RNAs.

Science 2005 Sep;309(5740):1519-24

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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September 2005

A protein sensor for siRNA asymmetry.

Science 2004 Nov;306(5700):1377-80

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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November 2004

Kinetic analysis of the RNAi enzyme complex.

Nat Struct Mol Biol 2004 Jul 30;11(7):599-606. Epub 2004 May 30.

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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July 2004

RISC assembly defects in the Drosophila RNAi mutant armitage.

Cell 2004 Mar;116(6):831-41

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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March 2004

In vitro analysis of RNA interference in Drosophila melanogaster.

Methods 2003 Aug;30(4):330-6

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Lazare Research Building, Room 825, 364 Plantation Street, Worcester, MA 01605, USA.

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August 2003

Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways.

Mol Cell 2002 Sep;10(3):537-48

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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September 2002