Benjamin G Neel

Benjamin G Neel

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Benjamin G Neel

Publications by authors named "Benjamin G Neel"

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The Protein Tyrosine Phosphatase Receptor Delta Regulates Developmental Neurogenesis.

Cell Rep 2020 Jan;30(1):215-228.e5

Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto M5G 1X8, ON, Canada; Center for Integrative Biology, Facultad de Ciencias, Universidad Mayor, Santiago 8580745, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.11.033DOI Listing
January 2020

Catalytic dysregulation of SHP2 leading to Noonan syndromes affects platelet signaling and functions.

Blood 2019 12;134(25):2304-2317

Institut des Maladies Métaboliques et Cardiovasculaires, INSERM U1048 and Université Paul Sabatier, Toulouse, France.

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http://dx.doi.org/10.1182/blood.2019001543DOI Listing
December 2019

Corrigendum to: Off-target inhibition by active site-targeting SHP2 inhibitors.

FEBS Open Bio 2019 Dec;9(12):2174

Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.

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http://dx.doi.org/10.1002/2211-5463.12754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886290PMC
December 2019

Activated Thiol Sepharose-based proteomic approach to quantify reversible protein oxidation.

FASEB J 2019 Nov 26;33(11):12336-12347. Epub 2019 Aug 26.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1096/fj.201900693RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902679PMC
November 2019

Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma.

Nat Commun 2019 11 26;10(1):5367. Epub 2019 Nov 26.

Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, 10016, USA.

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http://dx.doi.org/10.1038/s41467-019-13116-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879755PMC
November 2019

N-Glycoproteomics of Patient-Derived Xenografts: A Strategy to Discover Tumor-Associated Proteins in High-Grade Serous Ovarian Cancer.

Cell Syst 2019 04 10;8(4):345-351.e4. Epub 2019 Apr 10.

University of Toronto, Department of Medical Biophysics, Toronto, ON M5G 1L7, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24054712193008
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http://dx.doi.org/10.1016/j.cels.2019.03.011DOI Listing
April 2019

Phase I study of local radiation and tremelimumab in patients with inoperable locally recurrent or metastatic breast cancer.

Oncotarget 2019 Apr 26;10(31):2947-2958. Epub 2019 Apr 26.

Department of Medical Oncology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.18632/oncotarget.26893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508206PMC
April 2019

SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models.

Cancer Discov 2018 10 25;8(10):1237-1249. Epub 2018 Jul 25.

Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine, NYU Langone Health, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-18-0444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170706PMC
October 2018

Vitamin C in Stem Cell Reprogramming and Cancer.

Trends Cell Biol 2018 09 30;28(9):698-708. Epub 2018 Apr 30.

Department of Pathology, New York University (NYU) School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2018.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102081PMC
September 2018

Off-target inhibition by active site-targeting SHP2 inhibitors.

FEBS Open Bio 2018 Sep 1;8(9):1405-1411. Epub 2018 Aug 1.

Laura and Isaac Perlmutter Cancer Center NYU Langone Health New York NY USA.

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http://dx.doi.org/10.1002/2211-5463.12493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120237PMC
September 2018

A Genomically Characterized Collection of High-Grade Serous Ovarian Cancer Xenografts for Preclinical Testing.

Am J Pathol 2018 05 16;188(5):1120-1131. Epub 2018 Feb 16.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2018.01.019DOI Listing
May 2018

Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner.

Sci Signal 2018 03 20;11(522). Epub 2018 Mar 20.

Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1126/scisignal.aao1591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915342PMC
March 2018

A ERK/RSK-mediated negative feedback loop regulates M-CSF-evoked PI3K/AKT activation in macrophages.

FASEB J 2018 02 4;32(2):875-887. Epub 2018 Jan 4.

Department of Orthopaedics, Brown University Alpert Medical School, Rhode Island Hospital, Providence, Rhode Island, USA.

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http://dx.doi.org/10.1096/fj.201700672RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888401PMC
February 2018

Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2.

Nat Commun 2017 09 6;8(1):466. Epub 2017 Sep 6.

Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, 430 East 29th Street, New York, NY, 10016, USA.

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http://dx.doi.org/10.1038/s41467-017-00503-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587708PMC
September 2017

Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome.

Nat Commun 2017 05 26;8:15518. Epub 2017 May 26.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 1L7.

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http://dx.doi.org/10.1038/ncomms15518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458545PMC
May 2017

Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer.

Cell Rep 2017 03;18(10):2343-2358

Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Medicine, University of Toronto, Toronto, ON M5G 2C4, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada; Division of Rheumatology, St. Michael's Hospital, Toronto, ON M5B 1W8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.02.028DOI Listing
March 2017

Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation.

Cell Rep 2017 03;18(12):2932-2942

Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Mayo Clinic Cancer Center, Rochester, MN 55902, USA; Department of Molecular Pharmacology and Experimental Therapeutics, Center for Individualized Medicine, Mayo Clinic College of Medicine, Rochester, MN 55902, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.02.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393048PMC
March 2017

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

Mol Cell 2017 Jan 5;65(2):347-360. Epub 2017 Jan 5.

Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663465PMC
January 2017

Cancer: Bad neighbours cause bad blood.

Nature 2016 11 26;539(7628):173-175. Epub 2016 Oct 26.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada.

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http://dx.doi.org/10.1038/nature19479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571895PMC
November 2016

Sticking It to Cancer with Molecular Glue for SHP2.

Cancer Cell 2016 08;30(2):194-196

Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY 10016, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558882PMC
August 2016

Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1).

J Biol Chem 2016 07 18;291(30):15641-52. Epub 2016 May 18.

From the Department of Medical Biophysics, Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario M5G 2M9, Canada

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http://dx.doi.org/10.1074/jbc.M116.714196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957048PMC
July 2016

Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1.

Blood 2016 Apr 15;127(14):1803-13. Epub 2016 Jan 15.

Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA; Program in Molecular and Cellular Physiology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA;

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http://dx.doi.org/10.1182/blood-2015-06-653006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825414PMC
April 2016

Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles.

J Exp Med 2016 Jan 14;213(1):25-34. Epub 2015 Dec 14.

Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136 Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136 Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136

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http://dx.doi.org/10.1084/jem.20150524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710200PMC
January 2016

Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies.

Proc Natl Acad Sci U S A 2016 Jan 11;113(4):984-9. Epub 2016 Jan 11.

Division of Hematology/Oncology, Department of Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106; Division of Hematology/Oncology, Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University, Atlanta, GA 30322;

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http://dx.doi.org/10.1073/pnas.1508535113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743778PMC
January 2016

Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance.

Cell 2016 Jan;164(1-2):293-309

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Laura and Isaac Perlmutter Cancer Centre, NYU-Langone Medical Center, NY 10016, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.11.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724865PMC
January 2016

Leukemogenic Ptpn11 allele causes defective erythropoiesis in mice.

PLoS One 2014 7;9(10):e109682. Epub 2014 Oct 7.

Princess Margaret Cancer Center, University Health Network, Toronto, Canada; Departments of Medical Biophysics and Biochemistry, University of Toronto, Toronto, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109682PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188809PMC
December 2015

Clinical Utility of Patient-Derived Xenografts to Determine Biomarkers of Prognosis and Map Resistance Pathways in EGFR-Mutant Lung Adenocarcinoma.

J Clin Oncol 2015 Aug 29;33(22):2472-80. Epub 2015 Jun 29.

Erin L. Stewart, Celine Mascaux, Nhu-An Pham, Shingo Sakashita, Jenna Sykes, Lucia Kim, Naoki Yanagawa, Ghassan Allo, Kota Ishizawa, Dennis Wang, Chang-Qi Zhu, Ming Li, Christine Ng, Ni Liu, Melania Pintilie, Petra Martin, Tom John, Igor Jurisica, Natasha B. Leighl, Benjamin G. Neel, Thomas K. Waddell, Frances A. Shepherd, Geoffrey Liu, Ming-Sound Tsao, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada; Lucia Kim, Inha University College of Medicine, Incheon, South Korea; and Tom John, Austin Hospital, Heidelberg, Australia.

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http://jco.ascopubs.org/content/33/22/2472.full.pdf
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http://200.40.135.66:90/toc/0873/2015/0873-20150801-22-09.pd
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.60.1492
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http://dx.doi.org/10.1200/JCO.2014.60.1492DOI Listing
August 2015

Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.

Proc Natl Acad Sci U S A 2015 May 4;112(21):6625-30. Epub 2015 May 4.

Department of Medical Biophysics, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada M5G 2M9;

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http://dx.doi.org/10.1073/pnas.1419895112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450377PMC
May 2015

Differential regulation of FGFR3 by PTPN1 and PTPN2.

Proteomics 2015 Jan 17;15(2-3):419-33. Epub 2014 Dec 17.

Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Canada; Department of Molecular Genetics, University of Toronto, Canada.

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http://dx.doi.org/10.1002/pmic.201400259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032629PMC
January 2015

Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome.

Nat Neurosci 2014 Dec 10;17(12):1736-43. Epub 2014 Nov 10.

Integrative Center for Learning and Memory, Departments of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology and Brain Research Institute, University of California Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.1038/nn.3863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716736PMC
December 2014

New pROSpects for PTP1B: micro-managing oncogene-induced senescence.

Mol Cell 2014 Sep;55(5):651-3

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2M9, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765140067
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http://dx.doi.org/10.1016/j.molcel.2014.08.015DOI Listing
September 2014

Next-generation sequencing identifies rare variants associated with Noonan syndrome.

Proc Natl Acad Sci U S A 2014 Aug 21;111(31):11473-8. Epub 2014 Jul 21.

Department of Genetics, Harvard Medical School, Boston, MA 02115;Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1324128111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128129PMC
August 2014

From an orphan disease to a generalized molecular mechanism: PTPN11 loss-of-function mutations in the pathogenesis of metachondromatosis.

Rare Dis 2013 2;1:e26657. Epub 2013 Oct 2.

Princess Margaret Cancer Center; University Health Network and Department of Medical Biophysics; University of Toronto; Toronto, ON Canada.

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http://dx.doi.org/10.4161/rdis.26657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927490PMC
July 2014

Hepatocyte-specific Ptpn6 deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: potential role of PPARγ.

Hepatology 2014 May 1;59(5):1803-15. Epub 2014 Apr 1.

Department of Medicine, Cardiology Axis of the Institut Universitaire de Cardiologie et de Pneumologie de Québec (Hôpital Laval), Ste-Foy, Québec, Canada.

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http://dx.doi.org/10.1002/hep.26957DOI Listing
May 2014

The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1.

Cancer Cell 2014 Feb;25(2):181-95

Princess Margaret Cancer Center, University Health Network, 101 College Street, Room 8-703, Toronto Medical Discovery Tower, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Medicine, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Department of Medical Biophysics, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Division of Rheumatology, St. Michael's Hospital, 30 Bond Street, Toronto, ON M5B 1W8, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108140003
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http://dx.doi.org/10.1016/j.ccr.2014.01.025DOI Listing
February 2014

Biologically-targeted detection of primary and micro-metastatic ovarian cancer.

Theranostics 2013 25;3(6):420-7. Epub 2013 May 25.

Department of Medical Biophysics, Princess Margarete Cancer Center, University of Toronto, Toronto, Canada.

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http://www.thno.org/v03p0420.pdf
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http://www.thno.org/v03p0420.htm
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http://dx.doi.org/10.7150/thno.6413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677412PMC
January 2014

Diverse levels of sequence selectivity and catalytic efficiency of protein-tyrosine phosphatases.

Biochemistry 2014 Jan 7;53(2):397-412. Epub 2014 Jan 7.

Department of Chemistry and Biochemistry, The Ohio State University , 484 West 12th Avenue, Columbus, Ohio 43210, United States.

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http://dx.doi.org/10.1021/bi401223rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954597PMC
January 2014

Antagonism between binding site affinity and conformational dynamics tunes alternative cis-interactions within Shp2.

Nat Commun 2013 ;4:2037

Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1038/ncomms3037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777412PMC
December 2013

Shp1 regulates T cell homeostasis by limiting IL-4 signals.

J Exp Med 2013 Jul;210(7):1419-31

Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 2C1, Canada.

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http://dx.doi.org/10.1084/jem.20122239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698519PMC
July 2013

Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling.

Nature 2013 Jul 17;499(7459):491-5. Epub 2013 Jul 17.

Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, Rhode Island 02903, USA.

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http://dx.doi.org/10.1038/nature12396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148013PMC
July 2013

Erk1 and Erk2 are required for maintenance of hematopoietic stem cells and adult hematopoiesis.

Blood 2013 May 26;121(18):3594-8. Epub 2013 Feb 26.

Campbell Family Cancer Research Institute, Ontario Cancer Institute, Toronto, ON, Canada.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2012-12-47
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http://dx.doi.org/10.1182/blood-2012-12-476200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643760PMC
May 2013

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function.

Blood 2013 May 18;121(20):4205-20. Epub 2013 Mar 18.

Centre for Cardiovascular Sciences, School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, United Kingdom.

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http://dx.doi.org/10.1182/blood-2012-08-449272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656453PMC
May 2013

NMR-based functional profiling of RASopathies and oncogenic RAS mutations.

Proc Natl Acad Sci U S A 2013 Mar 4;110(12):4574-9. Epub 2013 Mar 4.

Campbell Family Cancer Research Institute, Ontario Cancer Institute, Toronto, ON, Canada M5G 1L7.

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http://dx.doi.org/10.1073/pnas.1218173110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607025PMC
March 2013

Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice.

Immunity 2013 Mar;38(3):489-501

Department of Laboratory Medicine and the Program in Immunology, University of California, San Francisco 94143, USA.

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http://dx.doi.org/10.1016/j.immuni.2013.02.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613338PMC
March 2013

Methods to monitor classical protein-tyrosine phosphatase oxidation.

FEBS J 2013 Jan 30;280(2):459-75. Epub 2012 May 30.

Department of Medical Biophysics, University of Toronto, Toronto, Canada.

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http://doi.wiley.com/10.1111/j.1742-4658.2012.08626.x
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http://dx.doi.org/10.1111/j.1742-4658.2012.08626.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439553PMC
January 2013

Dominant role of the protein-tyrosine phosphatase CD148 in regulating platelet activation relative to protein-tyrosine phosphatase-1B.

Arterioscler Thromb Vasc Biol 2012 Dec 11;32(12):2956-65. Epub 2012 Oct 11.

Centre for Cardiovascular Sciences, Institute of Biomedical Research, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.

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http://dx.doi.org/10.1161/ATVBAHA.112.300447DOI Listing
December 2012

Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement.

J Cell Sci 2012 Nov 12;125(Pt 22):5535-45. Epub 2012 Sep 12.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

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http://jcs.biologists.org/lookup/doi/10.1242/jcs.111260
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http://dx.doi.org/10.1242/jcs.111260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561861PMC
November 2012

Regulation of CD133 by HDAC6 promotes β-catenin signaling to suppress cancer cell differentiation.

Cell Rep 2012 Oct 19;2(4):951-63. Epub 2012 Oct 19.

Donnelly Centre and Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5S 3E1, Canada.

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http://dx.doi.org/10.1016/j.celrep.2012.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590846PMC
October 2012

Hepatocyte-specific Ptpn6 deletion protects from obesity-linked hepatic insulin resistance.

Diabetes 2012 Aug 14;61(8):1949-58. Epub 2012 Jun 14.

Department of Medicine, Faculty of Medicine, Cardiology Axis of the Institut Universitaire de Cardiologie et de Pneumologie de Québec (Hôpital Laval), Québec, Québec, Canada.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db11-15
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http://dx.doi.org/10.2337/db11-1502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402325PMC
August 2012

The signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold.

Mol Cell 2012 Aug;47(3):469-83

Campbell Family Cancer Research Institute, Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.

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http://dx.doi.org/10.1016/j.molcel.2012.06.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462001PMC
August 2012

Tyrosyl phosphorylation toggles a Runx1 switch.

Genes Dev 2012 Jul;26(14):1520-6

Campbell Family Cancer Research Institute, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1101/gad.198051.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404380PMC
July 2012

Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature.

Proc Natl Acad Sci U S A 2012 Mar 27;109(11):4257-62. Epub 2012 Feb 27.

Institut National de la Santé et de la Recherche Médicale U1048 and Université Paul Sabatier, Institut des Maladies Métaboliques et Cardiovasculaires, F-31432 Toulouse, France.

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http://dx.doi.org/10.1073/pnas.1119803109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306697PMC
March 2012

Cancer genomics: technology, discovery, and translation.

J Clin Oncol 2012 Feb 23;30(6):647-60. Epub 2012 Jan 23.

FRCPC, Princess Margaret Hospital, Drug Development Program, 610 University Ave, Ste 5-718, Toronto, Ontario, M5G 2M9, Canada.

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http://dx.doi.org/10.1200/JCO.2011.39.2316DOI Listing
February 2012

Peroxiredoxin-controlled G-CSF signalling at the endoplasmic reticulum-early endosome interface.

J Cell Sci 2011 Nov 1;124(Pt 21):3695-705. Epub 2011 Nov 1.

Department of Hematology, Erasmus University Medical Center, 3015 GE Rotterdam, The Netherlands.

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http://dx.doi.org/10.1242/jcs.089656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215578PMC
November 2011

TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway.

Genes Dev 2011 Oct;25(19):2069-78

Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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http://dx.doi.org/10.1101/gad.17224711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197205PMC
October 2011

G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase.

Blood 2011 Jul 2;118(4):1077-86. Epub 2011 Jun 2.

Department of Pediatrics and Cellular and Molecular Biology, Children's Memorial Hospital and the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1182/blood-2009-12-261636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148159PMC
July 2011

Phenotypic heterogeneity and instability of human ovarian tumor-initiating cells.

Proc Natl Acad Sci U S A 2011 Apr 30;108(16):6468-73. Epub 2011 Mar 30.

Ontario Cancer Institute, Campbell Family Cancer Research Institute, Toronto, ON, Canada M5G 1L7.

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http://dx.doi.org/10.1073/pnas.1005529108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081039PMC
April 2011

Substrate specificity of protein tyrosine phosphatases 1B, RPTPα, SHP-1, and SHP-2.

Biochemistry 2011 Mar 18;50(12):2339-56. Epub 2011 Feb 18.

Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, United States.

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http://dx.doi.org/10.1021/bi1014453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074353PMC
March 2011

Regulation of kidney development by Shp2: an unbiased stereological analysis.

Anat Rec (Hoboken) 2010 Dec 23;293(12):2147-53. Epub 2010 Aug 23.

Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/ar.21236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992585PMC
December 2010

PTP1B regulates Eph receptor function and trafficking.

J Cell Biol 2010 Dec 6;191(6):1189-203. Epub 2010 Dec 6.

Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.

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http://dx.doi.org/10.1083/jcb.201005035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002030PMC
December 2010