Benjamin D Medoff

Benjamin D Medoff

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Benjamin D Medoff

Benjamin D Medoff

Publications by authors named "Benjamin D Medoff"

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Quantitative assessment of airway remodelling and response to allergen in asthma.

Respirology 2019 Nov 7;24(11):1073-1080. Epub 2019 Mar 7.

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/resp.13521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732047PMC
November 2019

Chronic Obstructive Pulmonary Disease: Back to the Basics.

Am J Respir Crit Care Med 2018 11;198(10):1241-1242

2 Division of Pulmonary and Critical Care Medicine Massachusetts General Hospital Boston, Massachusetts.

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http://dx.doi.org/10.1164/rccm.201806-1148EDDOI Listing
November 2018

Automated segmentation and quantification of airway mucus with endobronchial optical coherence tomography.

Biomed Opt Express 2017 Oct 26;8(10):4729-4741. Epub 2017 Sep 26.

Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1364/BOE.8.004729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654813PMC
October 2017

Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo.

Sci Transl Med 2016 10;8(359):359ra131

Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1126/scitranslmed.aag1424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389120PMC
October 2016

Allergic Non-Asthmatic Adults Have Regional Pulmonary Responses to Segmental Allergen Challenge.

PLoS One 2015 7;10(12):e0143976. Epub 2015 Dec 7.

Divisions of Pulmonary and Critical Care and Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143976PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671597PMC
June 2016

CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation.

J Immunol 2015 Jul 3;195(2):683-94. Epub 2015 Jun 3.

Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114; Division of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129;

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http://dx.doi.org/10.4049/jimmunol.1402983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489191PMC
July 2015

Lung T cells in HIV infection. Driven to exhaustion?

Am J Respir Crit Care Med 2015 Feb;191(4):370-1

1 Division of Pulmonary and Critical Care Medicine Massachusetts General Hospital and Harvard Medical School Boston, Massachusetts and.

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http://dx.doi.org/10.1164/rccm.201501-0011EDDOI Listing
February 2015

The role of CARMA1 in T cells.

Crit Rev Immunol 2013 ;33(3):219-43

Pulmonary and Critical Care Unit and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690520PMC
January 2014

Dedifferentiation of committed epithelial cells into stem cells in vivo.

Nature 2013 Nov 6;503(7475):218-23. Epub 2013 Nov 6.

1] Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA [2] Departments of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts 02114, USA [3] Department of Internal Medicine, Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA [4] Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA.

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https://ecor.mgh.harvard.edu/content/files/SAC/RajagopalNatu
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http://www.nature.com/doifinder/10.1038/nature12777
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http://dx.doi.org/10.1038/nature12777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035230PMC
November 2013

Fat, fire and muscle--the role of adiponectin in pulmonary vascular inflammation and remodeling.

Pulm Pharmacol Ther 2013 Aug 26;26(4):420-6. Epub 2012 Jun 26.

Pulmonary and Critical Care Unit and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.pupt.2012.06.006DOI Listing
August 2013

Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation.

J Allergy Clin Immunol 2013 Jun 28;131(6):1644-52. Epub 2013 Apr 28.

Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.

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http://dx.doi.org/10.1016/j.jaci.2013.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703653PMC
June 2013

IL-36α exerts pro-inflammatory effects in the lungs of mice.

PLoS One 2012 20;7(9):e45784. Epub 2012 Sep 20.

Center for Immunology and Inflammatory Diseases, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045784PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447790PMC
February 2013

Obesity and pulmonary arterial hypertension: Is adiponectin the molecular link between these conditions?

Pulm Circ 2011 Oct-Dec;1(4):440-7

The Pulmonary Center, Boston University School of Medicine, Boston, MA, USA.

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http://dx.doi.org/10.4103/2045-8932.93542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329073PMC
August 2012

CARMA1 is necessary for optimal T cell responses in a murine model of allergic asthma.

J Immunol 2011 Dec 9;187(12):6197-207. Epub 2011 Nov 9.

Pulmonary and Critical Care Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.4049/jimmunol.1101348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237896PMC
December 2011

18F-FDG uptake rate is a biomarker of eosinophilic inflammation and airway response in asthma.

J Nucl Med 2011 Nov 11;52(11):1713-20. Epub 2011 Oct 11.

Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.2967/jnumed.110.086355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855676PMC
November 2011

Variant alveolar lipoproteinosis: a syndrome with distinct clinical and pathological features.

Pathol Int 2011 Sep;61(9):509-17

Pathology Service Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1111/j.1440-1827.2011.02710.xDOI Listing
September 2011

Adiponectin decreases pulmonary arterial remodeling in murine models of pulmonary hypertension.

Am J Respir Cell Mol Biol 2011 Aug 12;45(2):340-7. Epub 2010 Nov 12.

Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1165/rcmb.2010-0316OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175561PMC
August 2011

Inhibiting CXCR3-dependent CD8+ T cell trafficking enhances tolerance induction in a mouse model of lung rejection.

J Immunol 2011 Jun 9;186(12):6830-8. Epub 2011 May 9.

Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1001049
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http://dx.doi.org/10.4049/jimmunol.1001049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859457PMC
June 2011

Interleukin-1 family member 9 stimulates chemokine production and neutrophil influx in mouse lungs.

Am J Respir Cell Mol Biol 2011 Feb 18;44(2):134-45. Epub 2010 Mar 18.

Department of Pediatrics, University of Florida, Gainesville, USA.

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http://dx.doi.org/10.1165/rcmb.2009-0315OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049228PMC
February 2011

Adiponectin lowers glucose production by increasing SOGA.

Am J Pathol 2010 Oct 2;177(4):1936-45. Epub 2010 Sep 2.

Departments of Nutrition, School of Medicine and Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.2353/ajpath.2010.100363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947288PMC
October 2010

Case records of the Massachusetts General Hospital. Case 16-2010. A 48-year-old man with a cough and pain in the left shoulder.

N Engl J Med 2010 May;362(21):2013-22

Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, USA.

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http://dx.doi.org/10.1056/NEJMcpc1002114DOI Listing
May 2010

Imaging of molecular probe activity with Born-normalized fluorescence optical projection tomography.

Opt Lett 2010 Apr;35(7):1088-90

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900933PMC
http://dx.doi.org/10.1364/OL.35.001088DOI Listing
April 2010

Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling.

Am J Respir Cell Mol Biol 2009 Oct 23;41(4):397-406. Epub 2009 Jan 23.

Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, CNY 8301, 149 13th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1165/rcmb.2008-0415OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746986PMC
October 2009

CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells.

Am J Respir Cell Mol Biol 2009 Mar 28;40(3):286-94. Epub 2008 Aug 28.

Center for Computational and Integrative Biology, Massachusetts General Hospital, Simches Research Building, Room 7222, 185 Cambridge Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1165/rcmb.2008-0129OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645526PMC
March 2009

Contribution of CCR4 and CCR8 to antigen-specific T(H)2 cell trafficking in allergic pulmonary inflammation.

J Allergy Clin Immunol 2009 Jan 4;123(1):67-73.e3. Epub 2008 Dec 4.

Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.jaci.2008.09.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782398PMC
January 2009

CD11b+ myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation.

J Immunol 2009 Jan;182(1):623-35

Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718444PMC
http://dx.doi.org/10.4049/jimmunol.182.1.623DOI Listing
January 2009

Differential requirement for CARMA1 in agonist-selected T-cell development.

Eur J Immunol 2009 Jan;39(1):78-84

Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02114, USA.

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http://doi.wiley.com/10.1002/eji.200838734
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http://dx.doi.org/10.1002/eji.200838734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747028PMC
January 2009

CXCR3-deficiency protects influenza-infected CCR5-deficient mice from mortality.

Eur J Immunol 2008 Dec;38(12):3376-87

Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.

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http://dx.doi.org/10.1002/eji.200838628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749081PMC
December 2008

T cell trafficking in allergic asthma: the ins and outs.

Annu Rev Immunol 2008 ;26:205-32

Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1146/annurev.immunol.26.021607.090312DOI Listing
June 2008

Invasive and noninvasive ventilation in patients with asthma.

Respir Care 2008 Jun;53(6):740-48; discussion 749-50

Center for Immunology and Inflammatory Diseases, Pulmonary and Critical Care Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA.

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June 2008

Development of a novel chemokine-mediated in vivo T cell recruitment assay.

J Immunol Methods 2008 Feb 9;331(1-2):127-39. Epub 2008 Jan 9.

Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1016/j.jim.2007.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2277098PMC
February 2008

Multiple chemokine receptors, including CCR6 and CXCR3, regulate antigen-induced T cell homing to the human asthmatic airway.

J Immunol 2007 Aug;179(3):1901-12

Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.4049/jimmunol.179.3.1901DOI Listing
August 2007

Oligomerization of CXCL10 is necessary for endothelial cell presentation and in vivo activity.

J Immunol 2006 Nov;177(10):6991-8

Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.4049/jimmunol.177.10.6991DOI Listing
November 2006

CXCR3 and its ligands in a murine model of obliterative bronchiolitis: regulation and function.

J Immunol 2006 Jun;176(11):7087-95

Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.4049/jimmunol.176.11.7087DOI Listing
June 2006

CARMA1 is critical for the development of allergic airway inflammation in a murine model of asthma.

J Immunol 2006 Jun;176(12):7272-7

Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, 02129, USA.

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http://dx.doi.org/10.4049/jimmunol.176.12.7272DOI Listing
June 2006

STAT1 in peripheral tissue differentially regulates homing of antigen-specific Th1 and Th2 cells.

J Immunol 2006 Apr;176(8):4959-67

Division of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://www.jimmunol.org/content/176/8/4959.full.pdf
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http://dx.doi.org/10.4049/jimmunol.176.8.4959DOI Listing
April 2006

Antibody-antigen interaction in the airway drives early granulocyte recruitment through BLT1.

Am J Physiol Lung Cell Mol Physiol 2006 Jan 26;290(1):L170-8. Epub 2005 Aug 26.

Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://www.physiology.org/doi/10.1152/ajplung.00212.2005
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http://dx.doi.org/10.1152/ajplung.00212.2005DOI Listing
January 2006

The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans.

Blood 2006 Jan 22;107(2):444-53. Epub 2005 Sep 22.

Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2005-06-23
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http://dx.doi.org/10.1182/blood-2005-06-2362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1490027PMC
January 2006

Pathogenic T-cell recruitment into the airway in human disease.

Ann N Y Acad Sci 2005 Dec;1062:220-41

Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Bldg. 149-8301, 13th St., Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1196/annals.1358.026DOI Listing
December 2005

Case 17-2005: acute chest syndrome and ARDS.

N Engl J Med 2005 Oct;353(14):1529-30; author reply 1529-30

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http://dx.doi.org/10.1056/NEJMc051864DOI Listing
October 2005

BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation.

J Exp Med 2005 Jul;202(1):97-110

Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1084/jem.20042481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212891PMC
July 2005

Case records of the Massachusetts General Hospital. Case 17-2005. A 22-year-old woman with back and leg pain and respiratory failure.

N Engl J Med 2005 Jun;352(23):2425-34

Pulmonary and Critical Care Unit, Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, USA.

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http://www.nejm.org/doi/10.1056/NEJMcpc059012
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http://dx.doi.org/10.1056/NEJMcpc059012DOI Listing
June 2005

Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment.

Nat Immunol 2003 Oct 31;4(10):982-90. Epub 2003 Aug 31.

Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://www.nature.com/articles/ni970
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http://dx.doi.org/10.1038/ni970DOI Listing
October 2003

Cutting edge: Th2 cell trafficking into the allergic lung is dependent on chemoattractant receptor signaling.

J Immunol 2002 Jul;169(2):651-5

Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.4049/jimmunol.169.2.651DOI Listing
July 2002

IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma.

J Immunol 2002 May;168(10):5278-86

Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.4049/jimmunol.168.10.5278DOI Listing
May 2002