Benjamin Bonavida

Benjamin Bonavida

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Benjamin Bonavida

Publications by authors named "Benjamin Bonavida"

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Therapeutic YY1 Inhibitors in Cancer: ALL in ONE.

Crit Rev Oncog 2017 ;22(1-2):37-47

Department of Microbiology, Immunology, & Molecular Genetics, David Geffen School of Medicine, Johnson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA.

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http://www.dl.begellhouse.com/journals/439f422d0783386a,4186
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http://dx.doi.org/10.1615/CritRevOncog.2017020472DOI Listing
April 2019

Targeting the Overexpressed YY1 in Cancer Inhibits EMT and Metastasis.

Crit Rev Oncog 2017 ;22(1-2):49-61

Department of Microbiology, Immunology, & Molecular Genetics, David Geffen School of Medicine, Johnson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA.

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http://dx.doi.org/10.1615/CritRevOncog.2017020473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955615PMC
April 2019

The Forgotten YY2 in Reported YY1 Expression Levels in Human Cancers.

Crit Rev Oncog 2017 ;22(1-2):63-73

Department of Microbiology, Immunology, & Molecular Genetics, David Geffen School of Medicine, Johnson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA.

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http://www.dl.begellhouse.com/journals/439f422d0783386a,4186
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http://dx.doi.org/10.1615/CritRevOncog.2017020475DOI Listing
April 2019

YY1 regulates cancer cell immune resistance by modulating PD-L1 expression.

Drug Resist Updat 2019 Mar 9;43:10-28. Epub 2019 Apr 9.

Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13687646193001
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http://dx.doi.org/10.1016/j.drup.2019.04.001DOI Listing
March 2019

RKIP: A Key Regulator in Tumor Metastasis Initiation and Resistance to Apoptosis: Therapeutic Targeting and Impact.

Cancers (Basel) 2018 Aug 24;10(9). Epub 2018 Aug 24.

Division of Surgical Oncology, School of Medicine, University of Crete, Heraklion, Crete 71500, Greece.

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http://dx.doi.org/10.3390/cancers10090287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162400PMC
August 2018

Exosomes derived from cancerous and non-cancerous cells regulate the anti-tumor response in the tumor microenvironment.

Genes Cancer 2018 Mar;9(3-4):87-100

Department of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.18632/genesandcancer.172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086005PMC
March 2018

A New Linkage between the Tumor Suppressor RKIP and Autophagy: Targeted Therapeutics.

Crit Rev Oncog 2018 ;23(5-6):281-305

Department of Microbiology, Immunology, & Molecular Genetics, David Geffen School of Medicine, Johnson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90025-1747.

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http://dx.doi.org/10.1615/CritRevOncog.2018027211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370048PMC
January 2018

Linking Autophagy and the Dysregulated NFκB/ SNAIL/YY1/RKIP/PTEN Loop in Cancer: Therapeutic Implications.

Crit Rev Oncog 2018 ;23(5-6):307-320

Department of Microbiology, Immunology, & Molecular Genetics, David Geffen School of Medicine, Johnson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90025-1747.

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http://www.dl.begellhouse.com/journals/439f422d0783386a,476e
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http://dx.doi.org/10.1615/CritRevOncog.2018027212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370039PMC
January 2018

Overexpression of RKIP and its cross-talk with several regulatory gene products in multiple myeloma.

J Exp Clin Cancer Res 2017 05 5;36(1):62. Epub 2017 May 5.

Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1186/s13046-017-0535-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420138PMC
May 2017

Crosstalks between Raf-kinase inhibitor protein and cancer stem cell transcription factors (Oct4, KLF4, Sox2, Nanog).

Tumour Biol 2017 Apr;39(4):1010428317692253

Department of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1177/1010428317692253DOI Listing
April 2017

Inverse correlation between the metastasis suppressor RKIP and the metastasis inducer YY1: Contrasting roles in the regulation of chemo/immuno-resistance in cancer.

Drug Resist Updat 2017 01 9;30:28-38. Epub 2017 Jan 9.

Department of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, United States. Electronic address:

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http://dx.doi.org/10.1016/j.drup.2017.01.001DOI Listing
January 2017

Yin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implication.

J Exp Clin Cancer Res 2016 May 25;35:84. Epub 2016 May 25.

Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1186/s13046-016-0359-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881184PMC
May 2016

Correlation between the overexpression of Yin Yang 1 and the expression levels of miRNAs in Burkitt's lymphoma: A computational study.

Oncol Lett 2016 Feb 14;11(2):1021-1025. Epub 2015 Dec 14.

Department of Biomedical and Biotechnological Sciences, Section of General and Clinical Pathology, and Oncology, University of Catania, I-95124 Catania, Italy.

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http://dx.doi.org/10.3892/ol.2015.4031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734029PMC
February 2016

Activation of Natural Killer Cells by Probiotics.

For Immunopathol Dis Therap 2016 ;7(1-2):41-55

Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.

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http://dx.doi.org/10.1615/ForumImmunDisTher.2016017095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467532PMC
January 2016

Dual roles of nitric oxide in the regulation of tumor cell response and resistance to photodynamic therapy.

Redox Biol 2015 Dec 31;6:311-317. Epub 2015 Jul 31.

Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132317150008
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http://dx.doi.org/10.1016/j.redox.2015.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556768PMC
December 2015

Nitric oxide-mediated sensitization of resistant tumor cells to apoptosis by chemo-immunotherapeutics.

Redox Biol 2015 Dec 18;6:486-494. Epub 2015 Aug 18.

NantBioScience, Inc., NantWorks, LLC., California NanoSystems Institute (CnSI) at the University of California, Los Angeles, CA 90095, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S22132317150010
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http://dx.doi.org/10.1016/j.redox.2015.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596920PMC
December 2015

Special collection: Nitric oxide in cancer.

Redox Biol 2015 Dec 25;6:505-506. Epub 2015 Sep 25.

Department of Microbiology, Immunology, and Molecular Genetics David Geffen School of Medicine Jonsson Comprehensive Cancer Center University of California, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2015.09.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600854PMC
December 2015

Regulation Of Cell Death Apoptotic Pathways By Nitric Oxide In Cancer: Reversal Of Drug/Immune Resistance.

Redox Biol 2015 08 30;5:415. Epub 2015 Dec 30.

Jonsson Comprehensive Cancer Center, University of California, Los Angeles, USA.

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http://dx.doi.org/10.1016/j.redox.2015.09.016DOI Listing
August 2015

The Role Of Nitric Oxide After Repeated Low Dose Photodynamic Treatments In Prostate Carcinoma Cells.

Redox Biol 2015 08 30;5:422-423. Epub 2015 Dec 30.

Department of Medical and Biological Sciences, University of Udine, Italy.

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http://dx.doi.org/10.1016/j.redox.2015.09.037DOI Listing
August 2015

Prognostic significance of YY1 protein expression and mRNA levels by bioinformatics analysis in human cancers: a therapeutic target.

Pharmacol Ther 2015 Jun 23;150:149-68. Epub 2015 Jan 23.

Department of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90095, United States.

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http://dx.doi.org/10.1016/j.pharmthera.2015.01.011DOI Listing
June 2015

Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implications.

Genes Cancer 2015 Mar;6(3-4):84-105

Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center and David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426947PMC
http://dx.doi.org/10.18632/genesandcancer.40DOI Listing
March 2015

RKIP-mediated chemo-immunosensitization of resistant cancer cells via disruption of the NF-κB/Snail/YY1/RKIP resistance-driver loop.

Crit Rev Oncog 2014 ;19(6):431-45

Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299472PMC
February 2015

Repeated sub-optimal photodynamic treatments with pheophorbide a induce an epithelial mesenchymal transition in prostate cancer cells via nitric oxide.

Nitric Oxide 2015 Feb 17;45:43-53. Epub 2015 Feb 17.

Department of Medical and Biological Sciences, School of Medicine, University of Udine, Udine, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.niox.2015.02.005DOI Listing
February 2015

Postulated mechanisms of resistance of B-cell non-Hodgkin lymphoma to rituximab treatment regimens: strategies to overcome resistance.

Semin Oncol 2014 Oct 12;41(5):667-77. Epub 2014 Aug 12.

Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, CA. Electronic address:

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http://dx.doi.org/10.1053/j.seminoncol.2014.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254685PMC
October 2014

NK cell phenotypic and functional heterogeneities and molecular mechanisms of cytotoxicity.

Crit Rev Oncog 2014 ;19(1-2):21-45

Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, USA.

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September 2014

Overexpression of Yin Yang 1 in bone marrow-derived human multiple myeloma and its clinical significance.

Int J Oncol 2014 Sep 20;45(3):1184-92. Epub 2014 Jun 20.

Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.3892/ijo.2014.2511DOI Listing
September 2014

Role of YY1 in the pathogenesis of prostate cancer and correlation with bioinformatic data sets of gene expression.

Genes Cancer 2014 Mar;5(3-4):71-83

Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, California.

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http://www.impactjournals.com/genesandcancer/index.php?abs=1
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091534PMC
http://dx.doi.org/10.18632/genesandcancer.12DOI Listing
March 2014

Nitric oxide-mediated activity in anti-cancer photodynamic therapy.

Nitric Oxide 2013 Apr 26;30:26-35. Epub 2013 Jan 26.

Department of Medical and Biological Sciences, School of Medicine, University of Udine, P.le Kolbe 4, 33100 Udine, Italy.

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http://dx.doi.org/10.1016/j.niox.2013.01.002DOI Listing
April 2013

Contribution of either YY1 or BclXL-induced inhibition by the NO-donor DETANONOate in the reversal of drug resistance, both in vitro and in vivo. YY1 and BclXL are overexpressed in prostate cancer.

Nitric Oxide 2013 Feb 11;29:17-24. Epub 2012 Dec 11.

Department of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/j.niox.2012.12.001DOI Listing
February 2013

Roles Each of Snail, Yin Yang 1 and RKIP in the Regulation of Tumor Cells Chemo-immuno-resistance to Apoptosis.

For Immunopathol Dis Therap 2013 ;4(1)

Department of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles.

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http://dx.doi.org/10.1615/ForumImmunDisTher.2013008299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811117PMC
January 2013

HIF-1 expression is associated with CCL2 chemokine expression in airway inflammatory cells: implications in allergic airway inflammation.

Respir Res 2012 Jul 23;13:60. Epub 2012 Jul 23.

Hospital Infantil de Mexico, Federico Gomez, Unidad de Investigacion en Enfermedades Oncologicas, Dr, Marquez No 262, Col, Doctores, Delegacion Cuahutemos, Mexico City CP 06720, Mexico.

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http://dx.doi.org/10.1186/1465-9921-13-60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439306PMC
July 2012

TRAF6 activation in multiple myeloma: a potential therapeutic target.

Clin Lymphoma Myeloma Leuk 2012 Jun 21;12(3):155-63. Epub 2012 Mar 21.

Department of Microbiology, Immunology, and Molecular Genetics, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S215226501200007
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http://dx.doi.org/10.1016/j.clml.2012.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799862PMC
June 2012

Low circulating serum levels of second mitochondria-derived activator of caspase (Smac/DIABLO) in patients with bladder cancer.

Int J Oncol 2012 Apr 3;40(4):1246-50. Epub 2012 Jan 3.

Department of Urology, Faculty of Medicine, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka 569-8686, Japan.

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http://dx.doi.org/10.3892/ijo.2012.1324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584575PMC
April 2012

Preface: special issue on yin yang 1 and oncogenesis.

Crit Rev Oncog 2011 ;16(3-4):141-2

Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, California, USA.

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March 2012

The novel role of Yin Yang 1 in the regulation of epithelial to mesenchymal transition in cancer via the dysregulated NF-κB/Snail/YY1/RKIP/PTEN Circuitry.

Crit Rev Oncog 2011 ;16(3-4):211-26

Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, USA.

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March 2012

Galiximab signals B-NHL cells and inhibits the activities of NF-κB-induced YY1- and snail-resistant factors: mechanism of sensitization to apoptosis by chemoimmunotherapeutic drugs.

Mol Cancer Ther 2012 Mar 19;11(3):572-81. Epub 2012 Jan 19.

Corresponding Author: Benjamin Bonavida, Department of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095, USA.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-11
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http://dx.doi.org/10.1158/1535-7163.MCT-11-0635DOI Listing
March 2012

Inhibition of Epithelial-to-Mesenchymal Transition (EMT) in Cancer by Nitric Oxide: Pivotal Roles of Nitrosylation of NF-κB, YY1 and Snail.

For Immunopathol Dis Therap 2012 ;3(2):125-133

Department of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, California.

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http://www.dl.begellhouse.com/journals/1a654bf03faf67ac,033e
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http://dx.doi.org/10.1615/ForumImmunDisTher.2012006065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982871PMC
January 2012

Development of rituximab-resistant B-NHL clones: an in vitro model for studying tumor resistance to monoclonal antibody-mediated immunotherapy.

Methods Mol Biol 2011 ;731:407-19

Department of Surgery, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1007/978-1-61779-080-5_33DOI Listing
August 2011

The anti-CD20 mAb LFB-R603 interrupts the dysregulated NF-κB/Snail/RKIP/PTEN resistance loop in B-NHL cells: role in sensitization to TRAIL apoptosis.

Int J Oncol 2011 Jun 23;38(6):1683-94. Epub 2011 Mar 23.

Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095-1747, USA.

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http://www.spandidos-publications.com/10.3892/ijo.2011.984
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http://dx.doi.org/10.3892/ijo.2011.984DOI Listing
June 2011

Unique Pattern of Overexpression of Raf-1 Kinase Inhibitory Protein in Its Inactivated Phosphorylated Form in Human Multiple Myeloma.

For Immunopathol Dis Therap 2011 Apr;2(2)

Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, CA.

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http://dx.doi.org/10.1615/ForumImmunDisTher.v2.i2.90DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839863PMC
April 2011

The histone deacetylase inhibitor LBH589 enhances the anti-myeloma effects of chemotherapy in vitro and in vivo.

Leuk Res 2011 Mar 21;35(3):373-9. Epub 2010 Jul 21.

Institute for Myeloma and Bone Cancer Research, West Hollywood, CA, USA.

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http://dx.doi.org/10.1016/j.leukres.2010.06.026DOI Listing
March 2011

Molecular mechanism of MART-1+/A*0201+ human melanoma resistance to specific CTL-killing despite functional tumor-CTL interaction.

Cancer Res 2011 Feb 15;71(4):1406-17. Epub 2010 Dec 15.

Department of Surgery, Molecular and Medical Pharmacology, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, California, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-1296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180868PMC
February 2011

Dual role of NO donors in the reversal of tumor cell resistance and EMT: Downregulation of the NF-κB/Snail/YY1/RKIP circuitry.

Nitric Oxide 2011 Jan 8;24(1):1-7. Epub 2010 Oct 8.

Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, Johnson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S108986031000422
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http://dx.doi.org/10.1016/j.niox.2010.10.001DOI Listing
January 2011

Viral infection and cancer: the NF-kappaB/Snail/RKIP loop regulates target cell sensitivity to apoptosis by cytotoxic lymphocytes.

Crit Rev Immunol 2010 ;30(1):31-46

Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA.

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October 2010

Prognostic significance of second mitochondria-derived activator of caspase (Smac/DIABLO) expression in bladder cancer and target for therapy.

Int J Oncol 2010 Aug;37(2):503-8

Department of Urology, Osaka Medical College, Takatsuki, Osaka 569-8686, Japan.

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August 2010

The Role of B-RAF Mutations in Melanoma and the Induction of EMT via Dysregulation of the NF-κB/Snail/RKIP/PTEN Circuit.

Genes Cancer 2010 May;1(5):409-420

Department of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA, USA.

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http://gan.sagepub.com/lookup/doi/10.1177/1947601910373795
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http://dx.doi.org/10.1177/1947601910373795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933925PMC
May 2010

The proteasome inhibitor CEP-18770 enhances the anti-myeloma activity of bortezomib and melphalan.

Br J Haematol 2010 Feb 1;148(4):569-81. Epub 2009 Dec 1.

Institute for Myeloma & Bone Cancer Research, 9201 W. Sunset Boulevard, West Hollywood, CA 90069, USA.

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http://dx.doi.org/10.1111/j.1365-2141.2009.08008.xDOI Listing
February 2010

Dysregulation of the cell survival/anti-apoptotic NF-kappaB pathway by the novel humanized BM-ca anti-CD20 mAb: implication in chemosensitization.

Int J Oncol 2009 Dec;35(6):1289-96

Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

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December 2009

Higher expression levels of 14-3-3sigma in ductal carcinoma in situ of the breast predict poorer outcome.

Cancer Biomark 2009 ;5(4):215-24

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1747, USA.

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http://dx.doi.org/10.3233/CBM-2009-0106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170666PMC
November 2009

Pivotal roles of snail inhibition and RKIP induction by the proteasome inhibitor NPI-0052 in tumor cell chemoimmunosensitization.

Cancer Res 2009 Nov 20;69(21):8376-85. Epub 2009 Oct 20.

Department of Microbiology, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, California 90095-736422, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-1069DOI Listing
November 2009

Rituximab-mediated cell signaling and chemo/immuno-sensitization of drug-resistant B-NHL is independent of its Fc functions.

Clin Cancer Res 2009 Nov 27;15(21):6582-94. Epub 2009 Oct 27.

Department of Microbiology, Immunology, and Molecular Genetics, Jonsson Comprehensive Cancer, David Geffen School of Medicine, University of California, Los Angeles, California 90095-1747, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-1234DOI Listing
November 2009

The activated NF-kappaB-Snail-RKIP circuitry in cancer regulates both the metastatic cascade and resistance to apoptosis by cytotoxic drugs.

Crit Rev Immunol 2009 ;29(3):241-54

Department of Microbiology, Immunology & Molecular Genetics, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095-736422, USA.

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September 2009

Combination treatment of malignant B cells using the anti-CD20 antibody rituximab and the anti-malarial artesunate.

Int J Oncol 2009 Jul;35(1):149-58

German Cancer Research Center, Pharmaceutical Biology (C015), D-69120 Heidelberg, Germany.

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July 2009

In vitro and in vivo sensitization of SW620 metastatic colon cancer cells to CDDP-induced apoptosis by the nitric oxide donor DETANONOate: Involvement of AIF.

Nitric Oxide 2009 May 10;20(3):182-94. Epub 2008 Dec 10.

Department of Surgery, University of Texas Southwestern at Dallas, 4500 Lancaster Road, Dallas, TX 75216, USA.

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http://dx.doi.org/10.1016/j.niox.2008.11.006DOI Listing
May 2009

BRAF and RKIP are significantly decreased in cutaneous squamous cell carcinoma.

Cell Cycle 2009 May 26;8(9):1402-8. Epub 2009 May 26.

Laboratory of Virology, Medical School, University of Crete, Heraklion, Crete, Greece.

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http://dx.doi.org/10.4161/cc.8.9.8308DOI Listing
May 2009

Chemosensitization and immunosensitization of resistant cancer cells to apoptosis and inhibition of metastasis by the specific NF-kappaB inhibitor DHMEQ.

Curr Pharm Des 2009 ;15(7):792-808

Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles CA 90095, USA.

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April 2009

Nitric oxide sensitizes tumor cells to TRAIL-induced apoptosis via inhibition of the DR5 transcription repressor Yin Yang 1.

Nitric Oxide 2009 Feb 22;20(1):39-52. Epub 2008 Aug 22.

Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, 10833 Le Conte Avenue, A2-060, Los Angeles, CA 90095-73622, USA.

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http://dx.doi.org/10.1016/j.niox.2008.08.001DOI Listing
February 2009

Nitric oxide donors: novel cancer therapeutics (review).

Int J Oncol 2008 Nov;33(5):909-27

Department of Gastrointestinal and Endocrine Surgery, UT Southwestern Medical Center/VA North Texas Health Care System, Dallas, TX 75216, USA.

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November 2008

The NF-kappaB inhibitors (bortezomib and DHMEQ) sensitise rituximab-resistant AIDS-B-non-Hodgkin lymphoma to apoptosis by various chemotherapeutic drugs.

Leuk Lymphoma 2008 Oct;49(10):1982-94

Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California 90095-1747, USA.

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http://dx.doi.org/10.1080/10428190802357071DOI Listing
October 2008

Novel therapeutic applications of nitric oxide donors in cancer: roles in chemo- and immunosensitization to apoptosis and inhibition of metastases.

Nitric Oxide 2008 Sep 24;19(2):152-7. Epub 2008 Apr 24.

Department of Microbiology, Immunology & Molecular Genetics, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095-1747, USA.

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http://dx.doi.org/10.1016/j.niox.2008.04.018DOI Listing
September 2008

NF-kappaB in the pathogenesis and treatment of multiple myeloma.

Curr Opin Hematol 2008 Jul;15(4):391-9

Institute for Myeloma & Bone Cancer Research, West Hollywood, CA 90069, USA.

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http://dx.doi.org/10.1097/MOH.0b013e328302c7f4DOI Listing
July 2008

Inhibition of Yin Yang 1-dependent repressor activity of DR5 transcription and expression by the novel proteasome inhibitor NPI-0052 contributes to its TRAIL-enhanced apoptosis in cancer cells.

J Immunol 2008 May;180(9):6199-210

Department of Microbiology, Immunology, and Molecular Genetics, Division of Surgical Oncology, David Geffen School of Medicine, University of California-Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747671PMC
http://dx.doi.org/10.4049/jimmunol.180.9.6199DOI Listing
May 2008

Potentiation of cytotoxicity by combination of imatinib and chlorimipramine in glioma.

Int J Oncol 2008 Apr;32(4):829-39

Department of Histology and Embryology, Istanbul University, Istanbul Faculty of Medicine, 34093 Capa, Istanbul, Turkey.

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April 2008

The NO TRAIL to YES TRAIL in cancer therapy (review).

Int J Oncol 2007 Oct;31(4):685-91

Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90095-1747, USA.

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October 2007

Regulation of tumor cell sensitivity to TRAIL-induced apoptosis by the metastatic suppressor Raf kinase inhibitor protein via Yin Yang 1 inhibition and death receptor 5 up-regulation.

J Immunol 2007 Oct;179(8):5441-53

Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095, USA.

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http://www.jimmunol.org/content/179/8/5441.full.pdf
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October 2007

Expression of X-linked inhibitor of apoptosis protein is a strong predictor of human prostate cancer recurrence.

Clin Cancer Res 2007 Oct;13(20):6056-63

Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, California 90095-1747, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-0960DOI Listing
October 2007

Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: roles of Fas, Apaf-1, NFkappaB, IAPs, Smac/DIABLO, and AIF.

J Surg Res 2007 Sep 2;142(1):184-94. Epub 2007 Jul 2.

Department of Gastrointestinal and Endocrine Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75216, USA.

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http://dx.doi.org/10.1016/j.jss.2006.12.551DOI Listing
September 2007

Reversal of resistance to cytotoxic cancer therapies: DHMEQ as a chemo-sensitizing and immuno-sensitizing agent.

Drug Resist Updat 2007 Feb-Apr;10(1-2):1-12. Epub 2007 Feb 15.

Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, CA 90095-1747, United States.

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http://linkinghub.elsevier.com/retrieve/pii/S136876460700003
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http://dx.doi.org/10.1016/j.drup.2007.01.002DOI Listing
June 2007

Reversal of tumor resistance to apoptotic stimuli by alteration of membrane fluidity: therapeutic implications.

Adv Cancer Res 2007 ;98:149-90

Department of Microbiology, Immunology, and Molecular Genetics, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1016/S0065-230X(06)98005-1DOI Listing
May 2007

Overexpression of XIAP expression in renal cell carcinoma predicts a worse prognosis.

Int J Oncol 2007 Apr;30(4):919-25

Department of Urology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.

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April 2007

Chemotherapeutic drugs sensitize cancer cells to TRAIL-mediated apoptosis: up-regulation of DR5 and inhibition of Yin Yang 1.

Mol Cancer Ther 2007 Apr;6(4):1387-99

Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA, USA.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-06
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http://dx.doi.org/10.1158/1535-7163.MCT-06-0521DOI Listing
April 2007

Development of rituximab-resistant lymphoma clones with altered cell signaling and cross-resistance to chemotherapy.

Cancer Res 2007 Feb;67(3):1270-81

Department of Microbiology, Immunology, and Molecular Genetics, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California-Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90024, USA.

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http://cancerres.aacrjournals.org/content/canres/67/3/1270.f
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-06-2184DOI Listing
February 2007

What signals are generated by anti-CD20 antibody therapy?

Curr Hematol Malig Rep 2006 Dec;1(4):205-13

Dept. of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine at UCLA, Jonnson Comprehensive Cancer Center, University of California at Los Angeles, CA 90095-1747, USA.

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http://dx.doi.org/10.1007/s11899-006-0001-zDOI Listing
December 2006

Molecular events contributing to cell death in malignant human hematopoietic cells elicited by an IgG3-avidin fusion protein targeting the transferrin receptor.

Blood 2006 Oct 27;108(8):2745-54. Epub 2006 Jun 27.

Division of Surgical Oncology, Department of Surgery, University of California-Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095-1782, USA.

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http://dx.doi.org/10.1182/blood-2006-04-020263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895578PMC
October 2006

Understanding tobacco smoke carcinogen NNK and lung tumorigenesis.

Int J Oncol 2006 Oct;29(4):745-52

Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095-1747, USA.

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October 2006

Involvement of the TNF-alpha autocrine-paracrine loop, via NF-kappaB and YY1, in the regulation of tumor cell resistance to Fas-induced apoptosis.

Clin Immunol 2006 Sep 19;120(3):297-309. Epub 2006 Jun 19.

Department of Microbiology, Immunology, and Molecular Genetics, Jonsson Comprehensive Cancer Center, University of California-Los Angeles, 10833 Le Conte Ave., Los Angeles, CA 90095-1747, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S152166160600117
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http://dx.doi.org/10.1016/j.clim.2006.03.015DOI Listing
September 2006

Therapeutic potential of nitric oxide in cancer.

Drug Resist Updat 2006 Jun 5;9(3):157-73. Epub 2006 Jul 5.

Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, 10833 Le Conte Avenue, A2-060 CHS, Los Angeles, CA, 90095-1747, USA.

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http://molpharm.aspetjournals.org/content/82/4/700.full.pdf
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http://link.springer.com/content/pdf/10.1007/s10456-012-9327
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http://linkinghub.elsevier.com/retrieve/pii/S136876460600037
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http://dx.doi.org/10.1016/j.drup.2006.05.003DOI Listing
June 2006