Publications by authors named "Benjamin B Gelman"

97Publications

Neuroinflammation associates with antioxidant heme oxygenase-1 response throughout the brain in persons living with HIV.

J Neurovirol 2020 Dec 10;26(6):846-862. Epub 2020 Sep 10.

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 280 Clinical Research Building, 415 Curie Blvd., Philadelphia, PA, 19104, USA.

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December 2020

Lipocalin-2 mediates HIV-1 induced neuronal injury and behavioral deficits by overriding CCR5-dependent protection.

Brain Behav Immun 2020 10 11;89:184-199. Epub 2020 Jun 11.

Division of Biomedical Sciences, School of Medicine, University of California, Riverside, 900 University Ave, Riverside, CA 92521, USA; Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:

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October 2020

Heme oxygenase-1 promoter (GT) polymorphism associates with HIV neurocognitive impairment.

Neurol Neuroimmunol Neuroinflamm 2020 05 10;7(3). Epub 2020 Apr 10.

From the Department of Neurology (R. Garza, A.J.G., B.L.B., Y.G.-M., A.L.G., D.L.K.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Department of Pathology (B.B.G.), University of Texas Medical Branch, Galveston; Department of Family Medicine & Public Health (B.T.), University of Botswana, Gaborone; Departments of Medicine and Biostatistics (R. Gross), Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Department of Medicine (S.L.L.), University of California, San Diego.

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May 2020

Epigenetic Suppression of HIV in Myeloid Cells by the BRD4-Selective Small Molecule Modulator ZL0580.

J Virol 2020 05 18;94(11). Epub 2020 May 18.

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA

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May 2020

White Matter Abnormalities Linked to Interferon, Stress Response, and Energy Metabolism Gene Expression Changes in Older HIV-Positive Patients on Antiretroviral Therapy.

Mol Neurobiol 2020 Feb 5;57(2):1115-1130. Epub 2019 Nov 5.

Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, CLS 1010, 450 Brookline Ave, Boston, MA, 02215, USA.

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February 2020

Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV.

J Clin Invest 2019 07 22;129(8):3361-3373. Epub 2019 Jul 22.

Department of Microbiology and Immunology, University of Texas Medical Branch (UTMB), Galveston, Texas, USA.

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July 2019

Frailty in medically complex individuals with chronic HIV.

AIDS 2019 08;33(10):1603-1611

Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.

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August 2019

Correlates of HIV RNA concentrations in cerebrospinal fluid during antiretroviral therapy: a longitudinal cohort study.

Lancet HIV 2019 07 14;6(7):e456-e462. Epub 2019 Jun 14.

Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Department of Medicine, University of California San Diego, San Diego, CA, USA. Electronic address:

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July 2019

HIV-induced neuroinflammation: impact of PAR1 and PAR2 processing by Furin.

Cell Death Differ 2019 10 25;26(10):1942-1954. Epub 2019 Jan 25.

Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (affiliated to the University of Montreal), 110 Pine Ave West, Montreal, QC, H2W1R7, Canada.

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October 2019

BACE1 Mediates HIV-Associated and Excitotoxic Neuronal Damage Through an APP-Dependent Mechanism.

J Neurosci 2018 05 9;38(18):4288-4300. Epub 2018 Apr 9.

Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104,

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May 2018

Heme oxygenase-1 promoter region (GT)n polymorphism associates with increased neuroimmune activation and risk for encephalitis in HIV infection.

J Neuroinflammation 2018 Mar 6;15(1):70. Epub 2018 Mar 6.

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 415 Curie Boulevard, 280C Clinical Research Building, Philadelphia, PA, 19104, USA.

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March 2018

When do models of NeuroAIDS faithfully imitate "the real thing"?

J Neurovirol 2018 04 18;24(2):146-155. Epub 2017 Dec 18.

Department of Neurology, University of Pennsylvania, Philadelphia, PA, 19104-6140, USA.

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April 2018

Friedreich Ataxia: Developmental Failure of the Dorsal Root Entry Zone.

J Neuropathol Exp Neurol 2017 Nov;76(11):969-977

Research Service, Veterans Affairs Medical Center, Albany, New York; Department of Pathology, Albany Medical College, Albany, New York; Department of Pathology and Laboratory Medicine, University of Texas Medical Branch, Galveston, Texas; Department of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, New York.

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November 2017

Heart and Nervous System Pathology in Compound Heterozygous Friedreich Ataxia.

J Neuropathol Exp Neurol 2017 Aug;76(8):665-675

Research Service, Veterans Affairs Medical Center, Albany, New York (ABB, AHK); Department of Pathology, Albany Medical Center, Albany, New York (JQ, AHK); Department of Pathology and Laboratory Medicine, University of Texas Medical Branch, Galveston, Texas (BBG); Department of Pediatrics and Neurology, University of Colorado, Aurora, Colorado (MY); and Centogene, Rostock, Germany (PB).

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August 2017

Modeling brain lentiviral infections during antiretroviral therapy in AIDS.

J Neurovirol 2017 08 16;23(4):577-586. Epub 2017 May 16.

Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Canada.

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August 2017

Measures of Physical and Mental Independence Among HIV-Positive Individuals: Impact of Substance Use Disorder.

AIDS Res Hum Retroviruses 2017 Oct 10;33(10):1048-1055. Epub 2017 Apr 10.

2 Department of Epidemiology, College of Public Health, University of Nebraska Medical Center , Omaha, Nebraska.

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October 2017

Spinal Cord Ventral Horns and Lymphoid Organ Involvement in Powassan Virus Infection in a Mouse Model.

Viruses 2016 08 12;8(8). Epub 2016 Aug 12.

Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.

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August 2016

The significance of intercalated discs in the pathogenesis of Friedreich cardiomyopathy.

J Neurol Sci 2016 Aug 4;367:171-6. Epub 2016 Jun 4.

Department of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, NY, USA.

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August 2016

Multilevel analysis of neuropathogenesis of neurocognitive impairment in HIV.

J Neurovirol 2016 08 4;22(4):431-41. Epub 2015 Dec 4.

Department of Psychiatry, University of California San Diego School of Medicine, La Jolla, CA, USA.

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August 2016

Altered Oligodendrocyte Maturation and Myelin Maintenance: The Role of Antiretrovirals in HIV-Associated Neurocognitive Disorders.

J Neuropathol Exp Neurol 2015 Nov;74(11):1093-118

From the Department of Neuroscience, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (BKJ, MVM); Department of Neurology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania (BKJ, HM, JBG); Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (BKJ, PJG, CAE, MAE, KLJ-S); Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana (AJB-K); Department of Pathology, University of Texas Medical Branch, Galveston, Texas (BBG) Department of Psychology, College of Liberal Arts, Temple University, Philadelphia, Pennsylvania (LAB); Center for Neurobiology and Behavior, Department of Psychiatry, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (CP).

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November 2015

The role of chemokine C-C motif ligand 2 genotype and cerebrospinal fluid chemokine C-C motif ligand 2 in neurocognition among HIV-infected patients.

AIDS 2015 Jul;29(12):1483-91

aDepartment of Psychiatry and Biobehavioral Sciences bDepartment of Family Medicine cDepartment of Obstetrics & Gynecology dDepartment of Epidemiology and Microbiology eDepartment of Immunology & Human Genetics fDepartment of Neurology, University of California, Los Angeles gGreater Los Angeles VA Healthcare System, Los Angeles, California hDepartment of Neurology iDepartment of Pathology jDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York kDepartment of Pathology lDepartment of Neuroscience mDepartment of Cell Biology, University of Texas Medical Branch, Galveston, Texas nDepartment of Psychiatry, University of California, San Diego, California, USA.

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July 2015

Primary Langerhans cell histiocytosis of the lacrimal gland in an adult.

Can J Ophthalmol 2015 Jun;50(3):e40-3

University of Texas Medical Branch in Galveston, Galveston, Tex.

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June 2015

Neuropathology of HAND With Suppressive Antiretroviral Therapy: Encephalitis and Neurodegeneration Reconsidered.

Curr HIV/AIDS Rep 2015 Jun;12(2):272-9

Departments of Pathology and Neuroscience & Cell Biology, University of Texas Medical Branch, 301 University Blvd., Keiller 3.118A, Route 0609, Galveston, TX, 77555-0609, USA,

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June 2015

Absence of neurocognitive effect of hepatitis C infection in HIV-coinfected people.

Neurology 2015 Jan 10;84(3):241-50. Epub 2014 Dec 10.

From Washington University (D.B.C.), St. Louis, MO; University of California (F.V., Y.-T.K., D.R.F., S.L.L., I.G., R.K.H.), San Diego; University of Washington (A.C.C., C.M.M.), Seattle; University of Texas at Galveston (B.B.G.); Johns Hopkins University (J.C.M.), Baltimore, MD; and The Icahn School of Medicine at Mount Sinai (S.M., D.M.S.), New York, NY.

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January 2015

Astrocyte elevated gene-1 is a novel modulator of HIV-1-associated neuroinflammation via regulation of nuclear factor-κB signaling and excitatory amino acid transporter-2 repression.

J Biol Chem 2014 Jul 22;289(28):19599-612. Epub 2014 May 22.

From the Department of Cell Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107 and

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July 2014

Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline.

Neurology 2014 Jun 9;82(23):2055-62. Epub 2014 May 9.

From the University of California (I.G., D.R.F., R.D., S.P.W., F.V., R.J.E., S.L.L., T.D.M., J.H.A., J.A.M., I.A., A.G., C.F.-N., D.M.S., R.K.H.), San Diego; the University of Washington (A.C.C., C.M.M.), Seattle; Washington University (D.B.C.), St. Louis, MO; University of Texas Medical Branch (B.B.G.), Galveston; Johns Hopkins University (J.C.M.), Baltimore, MD; and The Icahn School of Medicine at Mount Sinai (S.M., D.M.S.), New York, NY.

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June 2014

Gp120 in the pathogenesis of human immunodeficiency virus-associated pain.

Ann Neurol 2014 Jun 28;75(6):837-50. Epub 2014 May 28.

Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX.

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June 2014

Quantitative neuropathology associated with chronic manganese exposure in South African mine workers.

Neurotoxicology 2014 Dec 26;45:260-6. Epub 2013 Dec 26.

School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Parktown, South Africa; Department of Neurology, Washington University School of Medicine, Saint Louis, MO, USA. Electronic address:

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December 2014

Wnt signaling in the pathogenesis of human HIV-associated pain syndromes.

J Neuroimmune Pharmacol 2013 Sep 5;8(4):956-64. Epub 2013 Jun 5.

Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555-1069, USA.

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September 2013

Chronic-pain-associated astrocytic reaction in the spinal cord dorsal horn of human immunodeficiency virus-infected patients.

J Neurosci 2012 Aug;32(32):10833-40

Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555, USA.

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August 2012

Substance abuse increases the risk of neuropathy in an HIV-infected cohort.

Muscle Nerve 2012 Apr;45(4):471-6

Department of Neurology, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1052, New York, New York 10029, USA.

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April 2012

Prefrontal dopaminergic and enkephalinergic synaptic accommodation in HIV-associated neurocognitive disorders and encephalitis.

J Neuroimmune Pharmacol 2012 Sep 6;7(3):686-700. Epub 2012 Mar 6.

Department of Pathology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-0609, USA.

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September 2012

Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders.

J Biol Chem 2011 Oct 4;286(40):34976-85. Epub 2011 Aug 4.

Department of Neurology, Molecular Studies of Neurodegenerative Diseases Laboratory, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

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October 2011

Efavirenz concentrations in CSF exceed IC50 for wild-type HIV.

J Antimicrob Chemother 2011 Feb 23;66(2):354-7. Epub 2010 Nov 23.

University of California San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, CA, USA.

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February 2011

Pathology and pathogenesis of sensory neuropathy in Friedreich's ataxia.

Acta Neuropathol 2010 Jul 26;120(1):97-108. Epub 2010 Mar 26.

VA Medical Center, Albany, NY 12208, USA.

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July 2010

Persistent hijacking of brain proteasomes in HIV-associated dementia.

Am J Pathol 2010 Feb 24;176(2):893-902. Epub 2009 Dec 24.

Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA.

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February 2010

Synaptic proteins linked to HIV-1 infection and immunoproteasome induction: proteomic analysis of human synaptosomes.

J Neuroimmune Pharmacol 2010 Mar 20;5(1):92-102. Epub 2009 Aug 20.

Department of Pathology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA.

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March 2010

Molecular confirmation of Sappinia pedata as a causative agent of amoebic encephalitis.

J Infect Dis 2009 Apr;199(8):1139-42

Division of Parasitic Disease, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.

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April 2009

Low atazanavir concentrations in cerebrospinal fluid.

AIDS 2009 Jan;23(1):83-7

Skaggs School of Pharmacy andPharmaceutical Sciences, School of Medicine, Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, MC 0719, La Jolla, CA 92093-0719, USA.

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January 2009

The neuropathology of HIV.

Handb Clin Neurol 2007 ;85:301-17

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October 2012

Abnormal striatal dopaminergic synapses in National NeuroAIDS Tissue Consortium subjects with HIV encephalitis.

J Neuroimmune Pharmacol 2006 Dec 8;1(4):410-20. Epub 2006 Aug 8.

Department of Pathology, Route 0785, University of Texas Medical Branch, Galveston, Texas 77555-0785, USA.

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December 2006

Acquired neuronal channelopathies in HIV-associated dementia.

J Neuroimmunol 2004 Dec;157(1-2):111-9

Texas NeuroAIDS Research Center Department of Pathology, Rt 0785, University of Texas Medical Branch, Galveston, TX 77555-0785, USA.

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December 2004

Host genetic polymorphisms in human immunodeficiency virus-related neurologic disease.

J Neurovirol 2004 ;10 Suppl 1:67-73

Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9036, USA.

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May 2004

Neuropathological and ultrastructural features of amebic encephalitis caused by Sappinia diploidea.

J Neuropathol Exp Neurol 2003 Oct;62(10):990-8

Texas Center for NeuroAIDS Research, Department of Pathology, University of Texas Medical Branch at Galveston, Rt. 0785, Galveston, TX 77555-0785, USA.

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October 2003

Human microglial cell isolation from adult autopsy brain: brain pH, regional variation, and infection with human immunodeficiency virus type 1.

J Neurovirol 2003 Jun;9(3):346-57

Department of Pathology, The University of Texas Medical Branch, Galveston, Texas 77555-0609, USA.

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June 2003