Publications by authors named "Bengt Winblad"

100Publications

Huntingtin Levels are Elevated in Hippocampal Post-Mortem Samples of Alzheimer's Disease Brain.

Curr Alzheimer Res 2020 Dec 3. Epub 2020 Dec 3.

Division of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna. Sweden.

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http://dx.doi.org/10.2174/1567205017666201203125622DOI Listing
December 2020

Are neuropsychiatric symptoms in dementia linked to CSF biomarkers of synaptic and axonal degeneration?

Alzheimers Res Ther 2020 Nov 17;12(1):153. Epub 2020 Nov 17.

Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s13195-020-00718-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670701PMC
November 2020

Small molecule therapeutics for tauopathy in Alzheimer's disease: Walking on the path of most resistance.

Eur J Med Chem 2020 Oct 15:112915. Epub 2020 Oct 15.

Dept. of Neuroscience Care and Society, Div. of Neurogeriatrics, Karolinska Institutet, 17164, Solna, Sweden; Memory Clinic, Theme Aging, Karolinska University Hospital, 14186, Huddinge, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2020.112915DOI Listing
October 2020

Insulin-Independent and Dependent Glucose Transporters in Brain Mural Cells in CADASIL.

Front Genet 2020 15;11:1022. Epub 2020 Sep 15.

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.3389/fgene.2020.01022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522350PMC
September 2020

Regional Disconnection in Alzheimer Dementia and Amyloid-Positive Mild Cognitive Impairment: Association Between EEG Functional Connectivity and Brain Glucose Metabolism.

Brain Connect 2020 Nov 23. Epub 2020 Nov 23.

Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1089/brain.2020.0785DOI Listing
November 2020

Increased Cerebrospinal Fluid Concentration of ZnT3 Is Associated with Cognitive Impairment in Alzheimer's Disease.

J Alzheimers Dis 2020 ;77(3):1143-1155

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.3233/JAD-200498DOI Listing
January 2020

Dementia Diagnosis Is Associated with Changes in Antidiabetic Drug Prescription: An Open-Cohort Study of ∼130,000 Swedish Subjects over 14 Years.

J Alzheimers Dis 2020 ;76(4):1581-1594

Department of Neurobiology, Center for Alzheimer Research, Division of Clinical Geriatrics, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.

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http://dx.doi.org/10.3233/JAD-200618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504989PMC
January 2020

Proteomics Time-Course Study of App Knock-In Mice Reveals Novel Presymptomatic Aβ42-Induced Pathways to Alzheimer's Disease Pathology.

J Alzheimers Dis 2020 ;75(1):321-335

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Solna, Sweden.

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http://dx.doi.org/10.3233/JAD-200028DOI Listing
January 2020

Corrigendum to Quantitative EEG power and synchronization correlate with Alzheimer's disease CSF biomarkers Neurobiology of Aging 63 (2018) 88-95.

Neurobiol Aging 2020 07 9;91:171. Epub 2020 Apr 9.

Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden; Department of Geriatric Medicine, Memory Clinic, Karolinska University Hospital-Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neurobiolaging.2020.03.005DOI Listing
July 2020

Proximity ligation assay reveals both pre- and postsynaptic localization of the APP-processing enzymes ADAM10 and BACE1 in rat and human adult brain.

BMC Neurosci 2020 02 4;21(1). Epub 2020 Feb 4.

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, BioClinicum J9:20, Visionsgatan 4, 171 64, Solna, Sweden.

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http://dx.doi.org/10.1186/s12868-020-0554-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001251PMC
February 2020

Cholinesterase inhibitors in patients with diabetes mellitus and dementia: an open-cohort study of ~23 000 patients from the Swedish Dementia Registry.

BMJ Open Diabetes Res Care 2020 01;8(1)

Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Huddinge, Sweden.

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http://dx.doi.org/10.1136/bmjdrc-2019-000833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039592PMC
January 2020

Glycan biomarkers for Alzheimer disease correlate with T-tau and P-tau in cerebrospinal fluid in subjective cognitive impairment.

FEBS J 2020 Aug 14;287(15):3221-3234. Epub 2020 Jan 14.

Division of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Solna, Sweden.

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http://dx.doi.org/10.1111/febs.15197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496940PMC
August 2020

Secondary Stroke Prevention After Ischemic Stroke in Patients with Alzheimer's Disease and Other Dementia Disorders.

J Alzheimers Dis 2020 ;73(3):1013-1021

Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Huddinge, Sweden.

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http://dx.doi.org/10.3233/JAD-191011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081091PMC
January 2020

Metal Binding by GMP-1 and Its Pyrimido [1, 2]benzimidazole Analogs Confirms Protection Against Amyloid-β Associated Neurotoxicity.

J Alzheimers Dis 2020 ;73(2):695-705

Department of Neurobiology, Care sciences and Societ, Centre for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Solna, Sweden.

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http://dx.doi.org/10.3233/JAD-190695DOI Listing
November 2020

EEG time signature in Alzheimer´s disease: Functional brain networks falling apart.

Neuroimage Clin 2019 18;24:102046. Epub 2019 Oct 18.

Karolinska Institute, Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics and Karolinska University Hospital, Memory Clinic, Huddinge, Sweden.

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http://dx.doi.org/10.1016/j.nicl.2019.102046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909352PMC
September 2020

The Proteome of the Dentate Terminal Zone of the Perforant Path Indicates Presynaptic Impairment in Alzheimer Disease.

Mol Cell Proteomics 2020 01 7;19(1):128-141. Epub 2019 Nov 7.

Division of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.

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http://dx.doi.org/10.1074/mcp.RA119.001737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944231PMC
January 2020

Restoring synaptic function through multimodal therapeutics.

Prog Mol Biol Transl Sci 2019 25;168:257-275. Epub 2019 Jul 25.

Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, Center for Alzheimer Research, Solna, Sweden; Theme Aging, Karolinska University Hospital, Huddinge, Sweden.

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http://dx.doi.org/10.1016/bs.pmbts.2019.07.003DOI Listing
July 2020

Erythrocyte Amyloid Beta Peptide Isoform Distributions in Alzheimer and Mild Cognitive Impairment.

Curr Alzheimer Res 2019 ;16(11):1050-1054

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Solna, Sweden.

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http://dx.doi.org/10.2174/1567205016666191010104355DOI Listing
October 2020

Non-specific Detection of a Major Western Blotting Band in Human Brain Homogenates by a Multitude of Amyloid Precursor Protein Antibodies.

Front Aging Neurosci 2019 9;11:273. Epub 2019 Oct 9.

Division of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Science and Society, Karolinska Institutet, Solna, Sweden.

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http://dx.doi.org/10.3389/fnagi.2019.00273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794468PMC
October 2019

Dual Bioorthogonal Labeling of the Amyloid-β Protein Precursor Facilitates Simultaneous Visualization of the Protein and Its Cleavage Products.

J Alzheimers Dis 2019 ;72(2):537-548

Center for Alzheimer Research, Division of Neurogeriatrics, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Solna, Sweden.

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http://dx.doi.org/10.3233/JAD-190898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918917PMC
November 2020

Prevention of cognitive decline in old age-varying effects of interventions in different populations.

Ann Transl Med 2019 Jul;7(Suppl 3):S142

Aging Research Center and Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.21037/atm.2019.06.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685914PMC
July 2019

A Fragment of S38AA is a Novel Plasma Biomarker of Alzheimer's Disease.

J Alzheimers Dis 2019 ;71(4):1163-1174

Department of Neurobiology, Division for Neurogeriatrics, Care Sciences and Society (NVS), Karolinska Institutet, BioClinicum J9:20, Solna, Sweden.

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http://dx.doi.org/10.3233/JAD-190700DOI Listing
November 2020

Alzheimer's Disease: Erythrocyte 2,3-diphosphoglycerate Content and Circulating Erythropoietin.

Curr Alzheimer Res 2019 ;16(9):834-835

Department of Neurobiology, Care Sciences, and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Solna, Sweden.

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http://dx.doi.org/10.2174/1567205016666190827120108DOI Listing
September 2020

Assessing cost-effectiveness of early intervention in Alzheimer's disease: An open-source modeling framework.

Alzheimers Dement 2019 10 8;15(10):1309-1321. Epub 2019 Aug 8.

Division of Neurogeriatrics, Department for Neurobiology, Care Sciences and Society, Karolinska Institute, Solna, Sweden; H. Lundbeck A/S, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.jalz.2019.05.004DOI Listing
October 2019

Antipsychotic Treatment Associated With Increased Mortality Risk in Patients With Dementia. A Registry-Based Observational Cohort Study.

J Am Med Dir Assoc 2019 03;20(3):323-329.e2

Center for Alzheimer Research, Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden; Theme Aging, Karolinska University Hospital, Huddinge, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jamda.2018.12.019DOI Listing
March 2019

Residing in sheltered housing versus ageing in place - Population characteristics, health status and social participation.

Health Soc Care Community 2019 07 1;27(4):e313-e322. Epub 2019 Mar 1.

Department of Nursing, Umeå University, Umeå, Sweden.

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http://dx.doi.org/10.1111/hsc.12734DOI Listing
July 2019

The Bri2 and Bri3 BRICHOS Domains Interact Differently with Aβ and Alzheimer Amyloid Plaques.

J Alzheimers Dis Rep 2018 Feb 16;2(1):27-39. Epub 2018 Feb 16.

Department of Neurobiology, Care Sciences and Society (NVS), Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Huddinge, Sweden.

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/ADR-170051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159705PMC
February 2018

Neuronal Aβ42 is enriched in small vesicles at the presynaptic side of synapses.

Life Sci Alliance 2018 Jun 14;1(3):e201800028. Epub 2018 Jun 14.

Center for Alzheimer Research, Division of Neurogeriatrics, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Huddinge, Sweden.

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http://www.life-science-alliance.org/lookup/doi/10.26508/lsa
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http://dx.doi.org/10.26508/lsa.201800028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238618PMC
June 2018

identification and biochemical characterization of the human dicarboxylate clamp TPR protein interaction network.

FEBS Open Bio 2018 Nov 9;8(11):1830-1843. Epub 2018 Oct 9.

Division of Neurogeriatrics Department of Neuroscience Care and Society Karolinska Institutet Huddinge Sweden.

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http://doi.wiley.com/10.1002/2211-5463.12521
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http://dx.doi.org/10.1002/2211-5463.12521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212638PMC
November 2018

Autophagy-lysosomal defect in human CADASIL vascular smooth muscle cells.

Eur J Cell Biol 2018 Nov 22;97(8):557-567. Epub 2018 Oct 22.

Division of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Huddinge, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01719335183008
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http://dx.doi.org/10.1016/j.ejcb.2018.10.001DOI Listing
November 2018

Acute Stroke Care in Dementia: A Cohort Study from the Swedish Dementia and Stroke Registries.

J Alzheimers Dis 2018 ;66(1):185-194

Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer research, Karolinska Institutet, Huddinge, Sweden.

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http://dx.doi.org/10.3233/JAD-180653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294591PMC
September 2019

Development of GMP-1 a molecular chaperone network modulator protecting mitochondrial function and its assessment in fly and mice models of Alzheimer's disease.

J Cell Mol Med 2018 07 27;22(7):3464-3474. Epub 2018 Apr 27.

Division of Neurogeriatrics, Department of Neuroscience Care and Society, Karolinska Institutet, Huddinge, Sweden.

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http://dx.doi.org/10.1111/jcmm.13624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010752PMC
July 2018

Apolipoprotein E genotypes and longevity across dementia disorders.

Alzheimers Dement 2018 07 13;14(7):895-901. Epub 2018 Mar 13.

Department of Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK.

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http://dx.doi.org/10.1016/j.jalz.2018.02.003DOI Listing
July 2018

Differences in proliferation rate between CADASIL and control vascular smooth muscle cells are related to increased TGFβ expression.

J Cell Mol Med 2018 06 13;22(6):3016-3024. Epub 2018 Mar 13.

Karolinska Institute, Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Huddinge, Sweden.

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http://dx.doi.org/10.1111/jcmm.13534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980144PMC
June 2018

Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach.

Brain 2018 02;141(2):582-595

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Novum, Stockholm, Sweden.

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http://dx.doi.org/10.1093/brain/awx352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837272PMC
February 2018

Quantitative EEG power and synchronization correlate with Alzheimer's disease CSF biomarkers.

Neurobiol Aging 2018 03 16;63:88-95. Epub 2017 Nov 16.

Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden; Department of Geriatric Medicine, Memory Clinic, Karolinska University Hospital-Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.11.005DOI Listing
March 2018

Cost-Utility of Using Alzheimer's Disease Biomarkers in Cerebrospinal Fluid to Predict Progression from Mild Cognitive Impairment to Dementia.

J Alzheimers Dis 2017 ;60(4):1477-1487

Department of Neurobiology, Care Science and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institute, Huddinge, Sweden.

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http://dx.doi.org/10.3233/JAD-170324DOI Listing
July 2018

Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51.

Sci Rep 2017 10 27;7(1):14288. Epub 2017 Oct 27.

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Huddinge, Sweden.

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http://dx.doi.org/10.1038/s41598-017-14731-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660230PMC
October 2017

Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry.

World J Biol Psychiatry 2018 06 27;19(4):244-328. Epub 2017 Oct 27.

a Department of Psychiatry and Psychotherapy , Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg , Erlangen , Germany.

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http://dx.doi.org/10.1080/15622975.2017.1375556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916324PMC
June 2018

Tau hyperphosphorylation induces oligomeric insulin accumulation and insulin resistance in neurons.

Brain 2017 Dec;140(12):3269-3285

Karolinska Institutet, Center for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Stockholm, Sweden.

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http://dx.doi.org/10.1093/brain/awx256DOI Listing
December 2017

Thrombolysis in acute ischemic stroke in patients with dementia: A Swedish registry study.

Neurology 2017 Oct 6;89(18):1860-1868. Epub 2017 Oct 6.

From the Karolinska Institutet (E.Z., D.R., B.W.), Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Huddinge, Sweden; Department of Neurology (E.Z., M.G.K.), University Medical Centre, Ljubljana, Slovenia; Karolinska Institutet (M.v.E.), Department of Clinical Science and Education, Södersjukhuset, and Department of Medicine, Solna; Karolinska University Hospital (M.v.E.), Department of Clinical Pharmacology; Karolinska Institutet and Stockholm University (I.K., J.F., K.J.), Aging Research Center, Stockholm, Sweden; Jönköping University (I.K.), Institute of Gerontology, School of Health and Welfare, Aging Research Network-Jönköping; Karolinska Institutet (B.C.E., M.E., S.G.-P.), Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Huddinge, Sweden; Department of Geriatrics (B.C.E.), Hospital Universitario de Getafe, Madrid, Spain; Lund University (B.N.), Skane University Hospital, Department of Clinical Sciences Lund, Neurology; Karolinska University Hospital, Department of Geriatric Medicine (D.R., M.E., S.G.-P.); and Södersjukhuset (S.G.-P.), Department of Internal Medicine, Section for Neurology, Stockholm, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000004598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664294PMC
October 2017

CSF/serum albumin ratio in dementias: a cross-sectional study on 1861 patients.

Neurobiol Aging 2017 11 11;59:1-9. Epub 2017 Jul 11.

Department of Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK; UK Dementia Research Institute at UCL, London, UK.

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.06.028DOI Listing
November 2017

APP mouse models for Alzheimer's disease preclinical studies.

EMBO J 2017 09 1;36(17):2473-2487. Epub 2017 Aug 1.

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako, Japan

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http://dx.doi.org/10.15252/embj.201797397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579350PMC
September 2017

Subclinical white matter lesions and medial temporal lobe atrophy are associated with EEG slowing in a memory clinic cohort.

Clin Neurophysiol 2017 09 15;128(9):1575-1582. Epub 2017 Jun 15.

Department of Geriatric Medicine, Memory Clinic, Karolinska University Hospital-Huddinge, Stockholm, Sweden; Department of Neurobiology, Care Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.clinph.2017.05.018DOI Listing
September 2017

Diabetes in a Large Dementia Cohort: Clinical Characteristics and Treatment From the Swedish Dementia Registry.

Diabetes Care 2017 09 27;40(9):1159-1166. Epub 2017 Jun 27.

Center for Alzheimer Research, Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc16-251
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http://dx.doi.org/10.2337/dc16-2516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566285PMC
September 2017

Living Alone with Alzheimer's Disease: Data from SveDem, the Swedish Dementia Registry.

J Alzheimers Dis 2017 ;58(4):1265-1272

Department of Neurobiology, Care Sciences andSociety, Division of Neurogeriatrics, Karolinska Institutet, Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.3233/JAD-170102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523910PMC
May 2018

Alzheimer's disease biomarker development: a call to funding bodies.

Neurobiol Aging 2017 Apr;52:117-118

Center for Alzheimer Research, Division of Neurogeriatrics, Department of NVS, Karolinska Institutet, Huddinge, Sweden.

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.02.035DOI Listing
April 2017

Effects of Risperidone and Galantamine Treatment on Alzheimer's Disease Biomarker Levels in Cerebrospinal Fluid.

J Alzheimers Dis 2017 ;57(2):387-393

Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.3233/JAD-160758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203339PMC
February 2018

Predicting progression to dementia in persons with mild cognitive impairment using cerebrospinal fluid markers.

Alzheimers Dement 2017 Aug 17;13(8):903-912. Epub 2017 Feb 17.

Department of Psychiatry and Neuropsychology, Alzheimer Centre Limburg, School for Mental Health and Neurosciences, Maastricht University, Maastricht, The Netherlands; Alzheimer Centre and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jalz.2016.12.015DOI Listing
August 2017

27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation.

J Exp Med 2017 03 17;214(3):699-717. Epub 2017 Feb 17.

Division of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, 141 86 Stockholm, Sweden

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http://dx.doi.org/10.1084/jem.20160534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339669PMC
March 2017

Maturation and processing of the amyloid precursor protein is regulated by the potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2).

Biochem Biophys Res Commun 2017 01 23;483(1):352-358. Epub 2016 Dec 23.

Karolinska Institutet, Dept. of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Novum, Blickagången 6, 141 57, Huddinge, Sweden.

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http://dx.doi.org/10.1016/j.bbrc.2016.12.140DOI Listing
January 2017

Management of Acute Myocardial Infarction in Patients With Dementia: Data From SveDem, the Swedish Dementia Registry.

J Am Med Dir Assoc 2017 01 14;18(1):19-23. Epub 2016 Sep 14.

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division for Neurogeriatrics, Karolinska Institutet, Huddinge, Sweden; Department of Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jamda.2016.07.026DOI Listing
January 2017

The worldwide costs of dementia 2015 and comparisons with 2010.

Alzheimers Dement 2017 01 29;13(1):1-7. Epub 2016 Aug 29.

King's College London, The Global Observatory for Ageing and Dementia Care, Institute of Psychiatry, Psychology and Neuroscience, Health Service and Population Research Department, London, UK.

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http://dx.doi.org/10.1016/j.jalz.2016.07.150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5232417PMC
January 2017

Evidence-based prevention and treatment of dementia - Authors' reply.

Lancet Neurol 2016 09 20;15(10):1007-8. Epub 2016 Jul 20.

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, SE-141 57, Huddinge, Sweden.

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http://dx.doi.org/10.1016/S1474-4422(16)30128-4DOI Listing
September 2016

Elevations in the Levels of NF-κB and Inflammatory Chemotactic Factors in the Brains with Alzheimer's Disease - One Mechanism May Involve α3 Nicotinic Acetylcholine Receptor.

Curr Alzheimer Res 2016 ;13(11):1290-1301

Department of Pathology in the Affiliated Hospital and The Key Lab of Medical Molecular Biology, Guizhou Medical University, Guiyang 550004, P.R. of China.

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http://dx.doi.org/10.2174/1567205013666160703174254DOI Listing
October 2017

MCI Patients in Europe: Medication and Comorbidities. The DESCRIPA Study.

Curr Alzheimer Res 2016 ;13(12):1407-1413

AHEPA University Hospital, Department of Clinical Neurophysiology, Thessaloniki Greece.

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http://dx.doi.org/10.2174/1567205013666160603002704DOI Listing
October 2017

Assessment and Reporting of Driving Fitness in Patients with Dementia in Clinical Practice: Data from SveDem, the Swedish Dementia Registry.

J Alzheimers Dis 2016 05;53(2):631-8

Alzheimer's Disease Research Center, Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.3233/JAD-160254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969696PMC
May 2016

Pharmacological Modulations of the Serotonergic System in a Cell-Model of Familial Alzheimer's Disease.

J Alzheimers Dis 2016 05;53(1):349-61

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division for Neurogeriatrics, Karolinska Institutet, Novum, Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.3233/JAD-160046DOI Listing
May 2016

Association of Platelet Serotonin Levels in Alzheimer's Disease with Clinical and Cerebrospinal Fluid Markers.

J Alzheimers Dis 2016 05;53(2):621-30

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division for Neurogeriatrics, Karolinska Institutet, Novum, Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.3233/JAD-160022DOI Listing
May 2016

CAIDE Dementia Risk Score and biomarkers of neurodegeneration in memory clinic patients without dementia.

Neurobiol Aging 2016 06 18;42:124-31. Epub 2016 Mar 18.

Department of Geriatric Medicine, Memory Clinic, Karolinska University Hospital-Huddinge, Stockholm, Sweden; Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.03.007DOI Listing
June 2016

Super-resolution microscopy reveals γ-secretase at both sides of the neuronal synapse.

Acta Neuropathol Commun 2016 Mar 31;4:29. Epub 2016 Mar 31.

Department NVS, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, 141 57, Huddinge, Sweden.

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http://dx.doi.org/10.1186/s40478-016-0296-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818506PMC
March 2016

Amyloid-Related Imaging Abnormalities (ARIA) in Immunotherapy Trials for Alzheimer's Disease: Need for Prognostic Biomarkers?

J Alzheimers Dis 2016 03;52(2):417-20

Karolinska Institutet, Department of NVS, Center for Alzheimer Research, Division of Neurogeriatrics, Huddinge, Sweden.

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http://dx.doi.org/10.3233/JAD-160122DOI Listing
March 2016

Perforin Promotes Amyloid Beta Internalisation in Neurons.

Mol Neurobiol 2017 03 16;54(2):874-887. Epub 2016 Jan 16.

Division for Neurogeriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Center for Alzheimer Research, Karolinska Institutet, Novum 5th floor, Huddinge, 141 57, Sweden.

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http://dx.doi.org/10.1007/s12035-016-9685-9DOI Listing
March 2017

Alzheimer disease. Donepezil and nursing home placement--benefits and costs.

Nat Rev Neurol 2016 Jan;12(1):11-3

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Karolinska Institute, SE-171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1038/nrneurol.2015.237DOI Listing
January 2016

BRICHOS binds to a designed amyloid-forming β-protein and reduces proteasomal inhibition and aggresome formation.

Biochem J 2016 Jan 17;473(2):167-78. Epub 2015 Nov 17.

Department of Neurobiology, Care Sciences and Society (NVS), Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Novum 5th floor, 141 57 Huddinge, Sweden

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http://dx.doi.org/10.1042/BJ20150920DOI Listing
January 2016

The need for thorough phase II studies in medicines development for Alzheimer's disease.

Alzheimers Res Ther 2015 Oct 26;7(1):67. Epub 2015 Oct 26.

Karolinska Institutet, Department NVS, Center for Alzheimer Research, Division for Neurogeriatrics, Novum plan 5, 14157, Huddinge, Sweden.

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http://dx.doi.org/10.1186/s13195-015-0153-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620743PMC
October 2015

Mitochondrial dysfunction in a transgenic mouse model expressing human amyloid precursor protein (APP) with the Arctic mutation.

J Neurochem 2016 Feb 19;136(3):497-502. Epub 2015 Nov 19.

Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Huddinge, Sweden.

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http://dx.doi.org/10.1111/jnc.13410DOI Listing
February 2016

Same Ages, Same Genes: Same Brains, Same Pathologies?: Dementia Timings, Co-Occurring Brain Pathologies, ApoE Genotypes in Identical and Fraternal Age-matched Twins at Autopsy.

Alzheimer Dis Assoc Disord 2016 Apr-Jun;30(2):178-82

*Department NVS, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Huddinge∥Department of Pathology, Karolinska University Hospital¶Department of Medical Epidemiology and Biostatistics, Karolinska Institutet#Aging Research Center (ARC), Karolinska Institutet/Stockholm University, Stockholm**Department of Psychology, University of Göthenburg, Göthenburg††Department of Geriatric Rehabilitation, Värnamo Hospital, Värnamo, Sweden†Neuropathology Research, Biomedical Research Institute of New Jersey, BRInj, Cedar Knolls‡Atlantic Neuroscience Institute, Atlantic Health System, Overlook and Morristown Medical Center, Morristown, NJ§Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY‡‡Department of Psychology, University of Southern California, Los Angeles, CA.

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http://dx.doi.org/10.1097/WAD.0000000000000114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840096PMC
March 2018

Feelings of Hopelessness in Midlife and Cognitive Health in Later Life: A Prospective Population-Based Cohort Study.

PLoS One 2015 13;10(10):e0140261. Epub 2015 Oct 13.

Center for Alzheimer Research, Division of Neurogeriatrics, Department of NVS, Karolinska Institutet, Stockholm, Sweden; Aging Research Center (ARC), Department of NVS, Karolinska Institutet and Stockholm University, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140261PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604196PMC
June 2016

Cardiovascular Diseases in ~30,000 Patients in the Swedish Dementia Registry.

J Alzheimers Dis 2015 ;48(4):949-58

Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division for Neurogeriatrics, Huddinge, Sweden.

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http://dx.doi.org/10.3233/JAD-150499DOI Listing
August 2016

Autoantibodies Toward the Angiotensin 2 Type 1 Receptor: A Novel Autoantibody in Alzheimer's Disease.

J Alzheimers Dis 2015 ;47(2):523-9

Department of Immunology and Transfusion Medicine, Haukeland University Hospital, Bergen, Norway.

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http://dx.doi.org/10.3233/JAD-150053DOI Listing
July 2016