Bengt Winblad

Bengt Winblad

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Bengt Winblad

Bengt Winblad

Publications by authors named "Bengt Winblad"

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Acute Stroke Care in Dementia: A Cohort Study from the Swedish Dementia and Stroke Registries.

J Alzheimers Dis 2018 ;66(1):185-194

Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer research, Karolinska Institutet, Huddinge, Sweden.

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http://dx.doi.org/10.3233/JAD-180653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294591PMC
September 2019

A Fragment of S38AA is a Novel Plasma Biomarker of Alzheimer's Disease.

J Alzheimers Dis 2019 Sep 10. Epub 2019 Sep 10.

Department of Neurobiology, Division for Neurogeriatrics, Care Sciences and Society (NVS), Karolinska Institutet, BioClinicum J9:20, Solna, Sweden.

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http://dx.doi.org/10.3233/JAD-190700DOI Listing
September 2019

Assessing cost-effectiveness of early intervention in Alzheimer's disease: An open-source modeling framework.

Alzheimers Dement 2019 Aug 8. Epub 2019 Aug 8.

Division of Neurogeriatrics, Department for Neurobiology, Care Sciences and Society, Karolinska Institute, Solna, Sweden; H. Lundbeck A/S, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.jalz.2019.05.004DOI Listing
August 2019

Alzheimer's Disease: Erythrocyte 2,3-diphosphoglycerate content and circulating erythropoietin.

Curr Alzheimer Res 2019 Aug 27. Epub 2019 Aug 27.

Department of Neurobiology, Care Sciences, and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Solna. Sweden.

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http://dx.doi.org/10.2174/1567205016666190827120108DOI Listing
August 2019

Residing in sheltered housing versus ageing in place - Population characteristics, health status and social participation.

Health Soc Care Community 2019 Jul 1;27(4):e313-e322. Epub 2019 Mar 1.

Department of Nursing, Umeå University, Umeå, Sweden.

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http://dx.doi.org/10.1111/hsc.12734DOI Listing
July 2019

Antipsychotic Treatment Associated With Increased Mortality Risk in Patients With Dementia. A Registry-Based Observational Cohort Study.

J Am Med Dir Assoc 2019 Mar;20(3):323-329.e2

Center for Alzheimer Research, Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden; Theme Aging, Karolinska University Hospital, Huddinge, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jamda.2018.12.019DOI Listing
March 2019

Autophagy-lysosomal defect in human CADASIL vascular smooth muscle cells.

Eur J Cell Biol 2018 Nov 22;97(8):557-567. Epub 2018 Oct 22.

Division of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Huddinge, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01719335183008
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http://dx.doi.org/10.1016/j.ejcb.2018.10.001DOI Listing
November 2018

identification and biochemical characterization of the human dicarboxylate clamp TPR protein interaction network.

FEBS Open Bio 2018 Nov 9;8(11):1830-1843. Epub 2018 Oct 9.

Division of Neurogeriatrics Department of Neuroscience Care and Society Karolinska Institutet Huddinge Sweden.

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http://doi.wiley.com/10.1002/2211-5463.12521
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http://dx.doi.org/10.1002/2211-5463.12521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212638PMC
November 2018

Cost-Utility of Using Alzheimer's Disease Biomarkers in Cerebrospinal Fluid to Predict Progression from Mild Cognitive Impairment to Dementia.

J Alzheimers Dis 2017 ;60(4):1477-1487

Department of Neurobiology, Care Science and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institute, Huddinge, Sweden.

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http://dx.doi.org/10.3233/JAD-170324DOI Listing
July 2018

Apolipoprotein E genotypes and longevity across dementia disorders.

Alzheimers Dement 2018 07 13;14(7):895-901. Epub 2018 Mar 13.

Department of Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK.

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http://dx.doi.org/10.1016/j.jalz.2018.02.003DOI Listing
July 2018

Development of GMP-1 a molecular chaperone network modulator protecting mitochondrial function and its assessment in fly and mice models of Alzheimer's disease.

J Cell Mol Med 2018 07 27;22(7):3464-3474. Epub 2018 Apr 27.

Division of Neurogeriatrics, Department of Neuroscience Care and Society, Karolinska Institutet, Huddinge, Sweden.

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http://dx.doi.org/10.1111/jcmm.13624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010752PMC
July 2018

Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry.

World J Biol Psychiatry 2018 06 27;19(4):244-328. Epub 2017 Oct 27.

a Department of Psychiatry and Psychotherapy , Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg , Erlangen , Germany.

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http://dx.doi.org/10.1080/15622975.2017.1375556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916324PMC
June 2018

Differences in proliferation rate between CADASIL and control vascular smooth muscle cells are related to increased TGFβ expression.

J Cell Mol Med 2018 06 13;22(6):3016-3024. Epub 2018 Mar 13.

Karolinska Institute, Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Huddinge, Sweden.

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http://dx.doi.org/10.1111/jcmm.13534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980144PMC
June 2018

Neuronal Aβ42 is enriched in small vesicles at the presynaptic side of synapses.

Life Sci Alliance 2018 Jun 14;1(3):e201800028. Epub 2018 Jun 14.

Center for Alzheimer Research, Division of Neurogeriatrics, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Huddinge, Sweden.

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http://www.life-science-alliance.org/lookup/doi/10.26508/lsa
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http://dx.doi.org/10.26508/lsa.201800028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238618PMC
June 2018

Living Alone with Alzheimer's Disease: Data from SveDem, the Swedish Dementia Registry.

J Alzheimers Dis 2017 ;58(4):1265-1272

Department of Neurobiology, Care Sciences andSociety, Division of Neurogeriatrics, Karolinska Institutet, Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.3233/JAD-170102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523910PMC
May 2018

Same Ages, Same Genes: Same Brains, Same Pathologies?: Dementia Timings, Co-Occurring Brain Pathologies, ApoE Genotypes in Identical and Fraternal Age-matched Twins at Autopsy.

Alzheimer Dis Assoc Disord 2016 Apr-Jun;30(2):178-82

*Department NVS, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Huddinge∥Department of Pathology, Karolinska University Hospital¶Department of Medical Epidemiology and Biostatistics, Karolinska Institutet#Aging Research Center (ARC), Karolinska Institutet/Stockholm University, Stockholm**Department of Psychology, University of Göthenburg, Göthenburg††Department of Geriatric Rehabilitation, Värnamo Hospital, Värnamo, Sweden†Neuropathology Research, Biomedical Research Institute of New Jersey, BRInj, Cedar Knolls‡Atlantic Neuroscience Institute, Atlantic Health System, Overlook and Morristown Medical Center, Morristown, NJ§Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY‡‡Department of Psychology, University of Southern California, Los Angeles, CA.

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http://dx.doi.org/10.1097/WAD.0000000000000114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840096PMC
March 2018

Quantitative EEG power and synchronization correlate with Alzheimer's disease CSF biomarkers.

Neurobiol Aging 2018 03 16;63:88-95. Epub 2017 Nov 16.

Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden; Department of Geriatric Medicine, Memory Clinic, Karolinska University Hospital-Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.11.005DOI Listing
March 2018

Effects of Risperidone and Galantamine Treatment on Alzheimer's Disease Biomarker Levels in Cerebrospinal Fluid.

J Alzheimers Dis 2017 ;57(2):387-393

Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.3233/JAD-160758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203339PMC
February 2018

Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach.

Brain 2018 02;141(2):582-595

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Novum, Stockholm, Sweden.

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http://dx.doi.org/10.1093/brain/awx352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837272PMC
February 2018

The Bri2 and Bri3 BRICHOS Domains Interact Differently with Aβ and Alzheimer Amyloid Plaques.

J Alzheimers Dis Rep 2018 Feb 16;2(1):27-39. Epub 2018 Feb 16.

Department of Neurobiology, Care Sciences and Society (NVS), Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Huddinge, Sweden.

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/ADR-170051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159705PMC
February 2018

Tau hyperphosphorylation induces oligomeric insulin accumulation and insulin resistance in neurons.

Brain 2017 Dec;140(12):3269-3285

Karolinska Institutet, Center for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Stockholm, Sweden.

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http://dx.doi.org/10.1093/brain/awx256DOI Listing
December 2017

CSF/serum albumin ratio in dementias: a cross-sectional study on 1861 patients.

Neurobiol Aging 2017 11 11;59:1-9. Epub 2017 Jul 11.

Department of Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK; UK Dementia Research Institute at UCL, London, UK.

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.06.028DOI Listing
November 2017

MCI Patients in Europe: Medication and Comorbidities. The DESCRIPA Study.

Curr Alzheimer Res 2016 ;13(12):1407-1413

AHEPA University Hospital, Department of Clinical Neurophysiology, Thessaloniki Greece.

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October 2017

Elevations in the Levels of NF-κB and Inflammatory Chemotactic Factors in the Brains with Alzheimer's Disease - One Mechanism May Involve α3 Nicotinic Acetylcholine Receptor.

Curr Alzheimer Res 2016 ;13(11):1290-1301

Department of Pathology in the Affiliated Hospital and The Key Lab of Medical Molecular Biology, Guizhou Medical University, Guiyang 550004, P.R. of China.

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October 2017

Thrombolysis in acute ischemic stroke in patients with dementia: A Swedish registry study.

Neurology 2017 Oct 6;89(18):1860-1868. Epub 2017 Oct 6.

From the Karolinska Institutet (E.Z., D.R., B.W.), Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Huddinge, Sweden; Department of Neurology (E.Z., M.G.K.), University Medical Centre, Ljubljana, Slovenia; Karolinska Institutet (M.v.E.), Department of Clinical Science and Education, Södersjukhuset, and Department of Medicine, Solna; Karolinska University Hospital (M.v.E.), Department of Clinical Pharmacology; Karolinska Institutet and Stockholm University (I.K., J.F., K.J.), Aging Research Center, Stockholm, Sweden; Jönköping University (I.K.), Institute of Gerontology, School of Health and Welfare, Aging Research Network-Jönköping; Karolinska Institutet (B.C.E., M.E., S.G.-P.), Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Huddinge, Sweden; Department of Geriatrics (B.C.E.), Hospital Universitario de Getafe, Madrid, Spain; Lund University (B.N.), Skane University Hospital, Department of Clinical Sciences Lund, Neurology; Karolinska University Hospital, Department of Geriatric Medicine (D.R., M.E., S.G.-P.); and Södersjukhuset (S.G.-P.), Department of Internal Medicine, Section for Neurology, Stockholm, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000004598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664294PMC
October 2017

Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51.

Sci Rep 2017 10 27;7(1):14288. Epub 2017 Oct 27.

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Huddinge, Sweden.

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http://dx.doi.org/10.1038/s41598-017-14731-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660230PMC
October 2017

Increased Epileptiform EEG Activity and Decreased Seizure Threshold in Arctic APP Transgenic Mouse Model of Alzheimer's Disease.

Curr Alzheimer Res 2016 ;13(7):817-30

A.I. Virtanen Institute, University of Eastern Finland, PO Box 1627, 70211 Kuopio, Finland.

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September 2017

Diabetes in a Large Dementia Cohort: Clinical Characteristics and Treatment From the Swedish Dementia Registry.

Diabetes Care 2017 09 27;40(9):1159-1166. Epub 2017 Jun 27.

Center for Alzheimer Research, Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc16-251
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http://dx.doi.org/10.2337/dc16-2516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566285PMC
September 2017

Subclinical white matter lesions and medial temporal lobe atrophy are associated with EEG slowing in a memory clinic cohort.

Clin Neurophysiol 2017 09 15;128(9):1575-1582. Epub 2017 Jun 15.

Department of Geriatric Medicine, Memory Clinic, Karolinska University Hospital-Huddinge, Stockholm, Sweden; Department of Neurobiology, Care Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.clinph.2017.05.018DOI Listing
September 2017

APP mouse models for Alzheimer's disease preclinical studies.

EMBO J 2017 09 1;36(17):2473-2487. Epub 2017 Aug 1.

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako, Japan

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http://dx.doi.org/10.15252/embj.201797397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579350PMC
September 2017

Predicting progression to dementia in persons with mild cognitive impairment using cerebrospinal fluid markers.

Alzheimers Dement 2017 Aug 17;13(8):903-912. Epub 2017 Feb 17.

Department of Psychiatry and Neuropsychology, Alzheimer Centre Limburg, School for Mental Health and Neurosciences, Maastricht University, Maastricht, The Netherlands; Alzheimer Centre and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jalz.2016.12.015DOI Listing
August 2017

Alzheimer's disease biomarker development: a call to funding bodies.

Neurobiol Aging 2017 Apr;52:117-118

Center for Alzheimer Research, Division of Neurogeriatrics, Department of NVS, Karolinska Institutet, Huddinge, Sweden.

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.02.035DOI Listing
April 2017

Perforin Promotes Amyloid Beta Internalisation in Neurons.

Mol Neurobiol 2017 03 16;54(2):874-887. Epub 2016 Jan 16.

Division for Neurogeriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Center for Alzheimer Research, Karolinska Institutet, Novum 5th floor, Huddinge, 141 57, Sweden.

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http://dx.doi.org/10.1007/s12035-016-9685-9DOI Listing
March 2017

27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation.

J Exp Med 2017 03 17;214(3):699-717. Epub 2017 Feb 17.

Division of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, 141 86 Stockholm, Sweden

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http://dx.doi.org/10.1084/jem.20160534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339669PMC
March 2017

The worldwide costs of dementia 2015 and comparisons with 2010.

Alzheimers Dement 2017 01 29;13(1):1-7. Epub 2016 Aug 29.

King's College London, The Global Observatory for Ageing and Dementia Care, Institute of Psychiatry, Psychology and Neuroscience, Health Service and Population Research Department, London, UK.

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http://dx.doi.org/10.1016/j.jalz.2016.07.150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5232417PMC
January 2017

Management of Acute Myocardial Infarction in Patients With Dementia: Data From SveDem, the Swedish Dementia Registry.

J Am Med Dir Assoc 2017 01 14;18(1):19-23. Epub 2016 Sep 14.

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division for Neurogeriatrics, Karolinska Institutet, Huddinge, Sweden; Department of Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jamda.2016.07.026DOI Listing
January 2017

Maturation and processing of the amyloid precursor protein is regulated by the potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2).

Biochem Biophys Res Commun 2017 01 23;483(1):352-358. Epub 2016 Dec 23.

Karolinska Institutet, Dept. of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Novum, Blickagången 6, 141 57, Huddinge, Sweden.

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http://dx.doi.org/10.1016/j.bbrc.2016.12.140DOI Listing
January 2017

Evidence-based prevention and treatment of dementia - Authors' reply.

Lancet Neurol 2016 09 20;15(10):1007-8. Epub 2016 Jul 20.

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, SE-141 57, Huddinge, Sweden.

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http://dx.doi.org/10.1016/S1474-4422(16)30128-4DOI Listing
September 2016

Cardiovascular Diseases in ~30,000 Patients in the Swedish Dementia Registry.

J Alzheimers Dis 2015 ;48(4):949-58

Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division for Neurogeriatrics, Huddinge, Sweden.

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http://dx.doi.org/10.3233/JAD-150499DOI Listing
August 2016

Autoantibodies Toward the Angiotensin 2 Type 1 Receptor: A Novel Autoantibody in Alzheimer's Disease.

J Alzheimers Dis 2015 ;47(2):523-9

Department of Immunology and Transfusion Medicine, Haukeland University Hospital, Bergen, Norway.

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http://dx.doi.org/10.3233/JAD-150053DOI Listing
July 2016

Feelings of Hopelessness in Midlife and Cognitive Health in Later Life: A Prospective Population-Based Cohort Study.

PLoS One 2015 13;10(10):e0140261. Epub 2015 Oct 13.

Center for Alzheimer Research, Division of Neurogeriatrics, Department of NVS, Karolinska Institutet, Stockholm, Sweden; Aging Research Center (ARC), Department of NVS, Karolinska Institutet and Stockholm University, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140261PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604196PMC
June 2016

CAIDE Dementia Risk Score and biomarkers of neurodegeneration in memory clinic patients without dementia.

Neurobiol Aging 2016 06 18;42:124-31. Epub 2016 Mar 18.

Department of Geriatric Medicine, Memory Clinic, Karolinska University Hospital-Huddinge, Stockholm, Sweden; Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.03.007DOI Listing
June 2016

Association of Platelet Serotonin Levels in Alzheimer's Disease with Clinical and Cerebrospinal Fluid Markers.

J Alzheimers Dis 2016 05;53(2):621-30

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division for Neurogeriatrics, Karolinska Institutet, Novum, Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.3233/JAD-160022DOI Listing
May 2016

Pharmacological Modulations of the Serotonergic System in a Cell-Model of Familial Alzheimer's Disease.

J Alzheimers Dis 2016 05;53(1):349-61

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division for Neurogeriatrics, Karolinska Institutet, Novum, Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.3233/JAD-160046DOI Listing
May 2016

Assessment and Reporting of Driving Fitness in Patients with Dementia in Clinical Practice: Data from SveDem, the Swedish Dementia Registry.

J Alzheimers Dis 2016 05;53(2):631-8

Alzheimer's Disease Research Center, Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.3233/JAD-160254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969696PMC
May 2016

Amyloid-Related Imaging Abnormalities (ARIA) in Immunotherapy Trials for Alzheimer's Disease: Need for Prognostic Biomarkers?

J Alzheimers Dis 2016 03;52(2):417-20

Karolinska Institutet, Department of NVS, Center for Alzheimer Research, Division of Neurogeriatrics, Huddinge, Sweden.

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http://dx.doi.org/10.3233/JAD-160122DOI Listing
March 2016

Super-resolution microscopy reveals γ-secretase at both sides of the neuronal synapse.

Acta Neuropathol Commun 2016 Mar 31;4:29. Epub 2016 Mar 31.

Department NVS, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, 141 57, Huddinge, Sweden.

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http://dx.doi.org/10.1186/s40478-016-0296-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818506PMC
March 2016

Mitochondrial dysfunction in a transgenic mouse model expressing human amyloid precursor protein (APP) with the Arctic mutation.

J Neurochem 2016 Feb 19;136(3):497-502. Epub 2015 Nov 19.

Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Huddinge, Sweden.

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http://dx.doi.org/10.1111/jnc.13410DOI Listing
February 2016

BRICHOS binds to a designed amyloid-forming β-protein and reduces proteasomal inhibition and aggresome formation.

Biochem J 2016 Jan 17;473(2):167-78. Epub 2015 Nov 17.

Department of Neurobiology, Care Sciences and Society (NVS), Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Novum 5th floor, 141 57 Huddinge, Sweden

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http://dx.doi.org/10.1042/BJ20150920DOI Listing
January 2016

Alzheimer disease. Donepezil and nursing home placement--benefits and costs.

Nat Rev Neurol 2016 Jan;12(1):11-3

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Karolinska Institute, SE-171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1038/nrneurol.2015.237DOI Listing
January 2016

Benchmarking biomarker-based criteria for Alzheimer's disease: Data from the Swedish Dementia Registry, SveDem.

Alzheimers Dement 2015 Dec 13;11(12):1470-1479. Epub 2015 Jun 13.

Center for Alzheimer Research, Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society (NVS), Karolinska Institutet, Stockholm, Sweden; Department of Geriatric Medicine, Karolinska University Hospital, Huddinge, Sweden.

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http://dx.doi.org/10.1016/j.jalz.2015.04.007DOI Listing
December 2015

ADAM10 and BACE1 are localized to synaptic vesicles.

J Neurochem 2015 Nov 17;135(3):606-15. Epub 2015 Sep 17.

Karolinska Institutet, Department of Neurobiology, Care Science and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Huddinge, Sweden.

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http://dx.doi.org/10.1111/jnc.13287DOI Listing
November 2015

Loss of neprilysin alters protein expression in the brain of Alzheimer's disease model mice.

Proteomics 2015 Oct 13;15(19):3349-55. Epub 2015 Aug 13.

Karolinska Institutet, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Division for Neurogeriatrics, Huddinge, Sweden.

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http://dx.doi.org/10.1002/pmic.201400211DOI Listing
October 2015

The need for thorough phase II studies in medicines development for Alzheimer's disease.

Alzheimers Res Ther 2015 Oct 26;7(1):67. Epub 2015 Oct 26.

Karolinska Institutet, Department NVS, Center for Alzheimer Research, Division for Neurogeriatrics, Novum plan 5, 14157, Huddinge, Sweden.

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http://dx.doi.org/10.1186/s13195-015-0153-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620743PMC
October 2015

Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage.

FEBS J 2015 Sep 14;282(17):3438-51. Epub 2015 Jul 14.

Division for Neurogeriatrics, Department of NVS, Center for Alzheimer Research, Karolinska Institutet, Huddinge, Sweden.

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http://dx.doi.org/10.1111/febs.13353DOI Listing
September 2015

Cerebrospinal fluid tau and amyloid-β1-42 in patients with dementia.

Brain 2015 Sep 30;138(Pt 9):2716-31. Epub 2015 Jun 30.

1 Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden 8 UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.

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http://dx.doi.org/10.1093/brain/awv181DOI Listing
September 2015

Brain health: a primary health care viewpoint.

J Am Med Dir Assoc 2015 Sep 11;16(9):720-1. Epub 2015 Jul 11.

Division for Neurogeriatrics, Care Sciences and Society, Department of NVS, Center for Alzheimer Research, Karolinska Institutet, Huddinge, Sweden.

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http://dx.doi.org/10.1016/j.jamda.2015.06.012DOI Listing
September 2015

Dissociation of a BRICHOS trimer into monomers leads to increased inhibitory effect on Aβ42 fibril formation.

Biochim Biophys Acta 2015 Aug 17;1854(8):835-43. Epub 2015 Apr 17.

Karolinska Institutet, Department of NVS, Center for Alzheimer Research, Division of Neurogeriatrics, 141 57 Huddinge, Sweden; Department of Anatomy, Physiology and Biochemistry, The Biomedical Centre, Swedish University of Agricultural Sciences, Box 575, 751 23 Uppsala, Sweden; Institute of Mathematics and Natural Sciences, Tallinn University, Narva mnt 25, Tallinn 101 20, Estonia.

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https://linkinghub.elsevier.com/retrieve/pii/S15709639150010
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http://dx.doi.org/10.1016/j.bbapap.2015.04.005DOI Listing
August 2015

mTor mediates tau localization and secretion: Implication for Alzheimer's disease.

Biochim Biophys Acta 2015 Jul 17;1853(7):1646-57. Epub 2015 Mar 17.

Karolinska Institutet, NVS Department, Centrum for Alzheimer Research, Division for Neurogeriatrics, Novum, SE 14186 Stockholm, Sweden; Department of Neurology, Xuan Wu Hospital, Capital Medical University, China; Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing 100053, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2015.03.003DOI Listing
July 2015

Human brain proteins showing neuron-specific interactions with γ-secretase.

FEBS J 2015 Jul 2;282(14):2587-99. Epub 2015 Jul 2.

Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division for Neurogeriatrics, Huddinge, Sweden.

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http://dx.doi.org/10.1111/febs.13303DOI Listing
July 2015

HHEX_23 AA Genotype Exacerbates Effect of Diabetes on Dementia and Alzheimer Disease: A Population-Based Longitudinal Study.

PLoS Med 2015 Jul 14;12(7):e1001853. Epub 2015 Jul 14.

Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Stockholm Gerontology Research Center, Stockholm, Sweden.

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http://dx.doi.org/10.1371/journal.pmed.1001853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501827PMC
July 2015

Heart failure and dementia: survival in relation to types of heart failure and different dementia disorders.

Eur J Heart Fail 2015 Jun 10;17(6):612-9. Epub 2015 Jan 10.

Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division for Neurogeriatrics, Novum, Blickagången 6, 141 57, Huddinge, Sweden.

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http://dx.doi.org/10.1002/ejhf.222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674979PMC
June 2015

5-HT1B and other related serotonergic proteins are altered in APPswe mutation.

Neurosci Lett 2015 May 1;594:137-43. Epub 2015 Apr 1.

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Disease Research, Neurogeriatrics Division, Karolinska Institute, Novum, Blickagången 6, 141 57, Huddinge, Sweden; Centre for Age- Related Medicine, Stavanger University Hospital, Stavanger, Norway; Department of Neurology, Akershus University Hospital, Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2015.03.064DOI Listing
May 2015

Erratum to: Cardiovascular medication burden in dementia disorders: a nationwide study of 19, 743 dementia patients in the Swedish Dementia Registry.

Alzheimers Res Ther 2014 20;6(5-8):63. Epub 2014 Sep 20.

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Huddinge, 141 57, Sweden ; Department of Geriatric Medicine, Karolinska University Hospital, Stockholm, 141 86, Huddinge, Sweden.

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http://dx.doi.org/10.1186/s13195-014-0063-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255535PMC
March 2015

27-hydroxycholesterol mediates negative effects of dietary cholesterol on cognition in mice.

Behav Brain Res 2015 Feb 18;278:356-9. Epub 2014 Oct 18.

Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institute, Karolinska University Hospital, SE 141 86 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2014.10.018DOI Listing
February 2015

CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival.

Neurology 2014 Nov 22;83(21):1945-53. Epub 2014 Oct 22.

From the Clinical Neurochemistry Laboratory (T.S., C.R., N.M., K.B., H.Z.), Institute of Neuroscience and Physiology, Department of Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society (B.F., D.R., B.W., M.E.), and KI Alzheimer Disease Research Center (A.W.), Karolinska Institutet, Stockholm; Department of Geriatric Medicine (B.F., D.R., M.E.), Karolinska University Hospital, Stockholm, Sweden; Centre for Statistical Methodology (J.W.B.), London School of Hygiene & Tropical Medicine, London, UK; Department of Veterans Affairs Medical Center (N.M.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA; Clinical Memory Research Unit (K.N.), Department of Clinical Sciences Malmö, Lund University, Malmö; Department of Public Health and Caring Sciences/Geriatrics (L.K.), Uppsala University; Institute of Neuroscience and Physiology (L.R.), Department of Neurology, the Sahlgrenska Academy at the University of Gothenburg, Sweden; and UCL Institute of Neurology (J.M.S., H.Z.), Queen Square, London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000001015DOI Listing
November 2014

Cerebral ABC transporter-common mechanisms may modulate neurodegenerative diseases and depression in elderly subjects.

Arch Med Res 2014 Nov 11;45(8):738-43. Epub 2014 Nov 11.

Department NVS, Center for Alzheimer Research, Division for Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.arcmed.2014.10.010DOI Listing
November 2014

Subjective cognitive impairment subjects in our clinical practice.

Dement Geriatr Cogn Dis Extra 2014 Sep 11;4(3):419-30. Epub 2014 Nov 11.

Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Sweden ; Department of Geriatric Medicine, Karolinska University Hospital, Sweden.

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http://dx.doi.org/10.1159/000366270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264484PMC
September 2014