Publications by authors named "Benedikt W Pelzer"

11 Publications

  • Page 1 of 1

The role of the human gut microbiota in colonization and infection with multidrug-resistant bacteria.

Gut Microbes 2021 Jan-Dec;13(1):1-13

Department of Internal Medicine, Infectious Diseases, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt Am Main, Germany.

About 100 years ago, the first antibiotic drug was introduced into health care. Since then, antibiotics have made an outstanding impact on human medicine. However, our society increasingly suffers from collateral damage exerted by these highly effective drugs. The rise of resistant pathogen strains, combined with a reduction of microbiota diversity upon antibiotic treatment, has become a significant obstacle in the fight against invasive infections worldwide.Alternative and complementary strategies to classical "Fleming antibiotics" comprise microbiota-based treatments such as fecal microbiota transfer and administration of probiotics, live-biotherapeutics, prebiotics, and postbiotics. Other promising interventions, whose efficacy may also be influenced by the human microbiota, are phages and vaccines. They will facilitate antimicrobial stewardship, to date the only globally applied antibiotic resistance mitigation strategy.In this review, we present the available evidence on these nontraditional interventions, highlight their interaction with the human microbiota, and discuss their clinical applicability.
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http://dx.doi.org/10.1080/19490976.2021.1911279DOI Listing
April 2021

Attitudes and Knowledge of European Medical Students and Early Graduates about Vaccination and Self-Reported Vaccination Coverage-Multinational Cross-Sectional Survey.

Int J Environ Res Public Health 2021 03 30;18(7). Epub 2021 Mar 30.

European Medical Students' Association (EMSA), Rue Guimard 15, 1040 Brussels, Belgium.

Vaccination is one of the most useful preventive interventions in healthcare. The purpose of our study was to gain overview of the opinions, knowledge, and engagement in vaccination practices among medical students (MS) and junior doctors (JD) in Europe. The survey was distributed from March 2016 until August 2016 via the e-mail and social media of the European Medical Students' Association. In total, 1821 responses from MS and JD from 34 countries in the European region were analysed. The majority of respondents agreed that vaccines are useful (98.7%) and effective (97.2%). Although the necessity of revaccination was supported by 99.2%, only 68.0% of the respondents went through with it. Even though the potential benefit of the flu vaccination seems to be acknowledged by our participants, only 22.1% of MS and JD declared getting the flu shot every or every other season. MS and JD were in favour of specific mandatory vaccination for medical staff (86.0%) and medical students (82.7%). Furthermore, we analysed the self-reported vaccination coverage of our participants regarding 19 vaccines. Of the respondents, 89.5% claimed to provide advice about vaccination to their friends and family. In conclusion, European MS and JD have a very positive attitude towards vaccination. However, their behaviour and knowledge demonstrate certain gaps which should be further addressed in medical education.
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http://dx.doi.org/10.3390/ijerph18073595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036942PMC
March 2021

An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities.

Blood Cancer Discov 2021 Jan;2(1):70-91

Center for Integrated Oncology, University of Cologne, Cologne, Germany.

Based on gene expression profiles, diffuse large B cell lymphoma (DLBCL) is sub-divided into germinal center B cell-like (GCB) and activated B cell-like (ABC) DLBCL. Two of the most common genomic aberrations in ABC-DLBCL are mutations in , as well as copy number gains. Here, we employ immune phenotyping, RNA-Seq and whole exome sequencing to characterize a and -driven mouse model of ABC-DLBCL. We show that this model resembles features of human ABC-DLBCL. We further demonstrate an actionable dependence of our murine ABC-DLBCL model on BCL2. This BCL2 dependence was also detectable in human ABC-DLBCL cell lines. Moreover, human ABC-DLBCLs displayed increased expression, compared to GCB-DLBCL. experiments in our ABC-DLBCL model showed that combined venetoclax and RMP1-14 significantly increased the overall survival of lymphoma bearing animals, indicating that this combination may be a viable option for selected human ABC-DLBCL cases harboring and aberrations.
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http://dx.doi.org/10.1158/2643-3230.BCD-19-0059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806186PMC
January 2021

Youth activists for our health.

Lancet 2019 11;394(10213):1992

European Medical Students' Association, 1040 Brussels, Belgium.

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http://dx.doi.org/10.1016/S0140-6736(19)32625-XDOI Listing
November 2019

An Analysis of the Presence and Composition of OutLists at United States, Canadian, and European Medical Institutions.

J Homosex 2020 Dec 18;67(14):1999-2013. Epub 2019 Jul 18.

European Medical Students' Association , Brussels, Belgium.

Sexual and gender minority (SGM) medical students and physicians are exposed to bias in professional contexts. One strategy for promoting SGM visibility and inclusion within medicine is the development of institutional OutLists, which are online, opt-in lists of SGM-identified individuals affiliated with an academic institution. We present the first quantitative evaluation of publicly accessible OutLists at medical institutions in the United States, Canada, and Europe. Nineteen OutLists were identified in the United States; no OutLists were identified in other countries. All OutLists in the United States were identified at allopathic institutions with no institutional religious affiliation. Clinicians in high-prestige specialties and more senior clinicians were underrepresented on OutLists. A state-level measure of SGM equality predicted presence of OutLists within the state (odds ratio 1.429, = .047) but was not associated with the total number of individuals on OutLists. Future research would benefit from incorporating qualitative methodologies to explore the effectiveness of OutLists and the individual experiences of participants in these lists.
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http://dx.doi.org/10.1080/00918369.2019.1621554DOI Listing
December 2020

Light chain monoclonal gammopathy of undetermined significance is characterized by a high disappearance rate and low risk of progression on longitudinal analysis.

Ann Hematol 2018 Aug 9;97(8):1463-1469. Epub 2018 Apr 9.

Department of Hematology, University Hospital Essen, Hufelandstr. 55, D-45122, Essen, Germany.

We determined the 10-year progression rate of light chain monoclonal gammopathy of undetermined significance (LCMGUS) and investigated potential associations with cancer utilizing the German population-based Heinz Nixdorf Recall Study. The Heinz Nixdorf Recall Study comprises 4814 men and women aged 45-75 years. Serum samples from baseline (2000-2003) and five-year (2006-2008) and 10-year (2011-2015) follow-up examinations were screened for monoclonal free light chains (FLC). LCMGUS was defined as abnormal FLC ratio, increase of involved FLC with complete loss of immunoglobulin heavy chain, and absence of a history of lymphoproliferative disease (LPD). Seventy-five individuals with LCMGUS were identified across all three evaluation time points (median age 64 years; 43 (57%) male; FLCR > 1.65 65 (87%); FLCR ≤ 0.65 10 (13%)). After a median observation time of 11.5 years, none of the LCMGUS cases had progressed to overt LPD; in particular, we did not observe incident light chain multiple myeloma. On serial analysis 17/31 (55%), LCMGUS could not be confirmed and disappearance of the monoclonal protein was associated with low concentrations of the involved FLC. Individuals with LCMGUS had a 1.5-fold increased risk of cancer but did not show differences in overall survival or renal function as compared to individuals with normal FLC. In conclusion, LCMGUS represents a relatively benign condition with a high disappearance rate of the monoclonal protein on longitudinal analysis and normal overall survival at least in the population-based setting.
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http://dx.doi.org/10.1007/s00277-018-3305-xDOI Listing
August 2018

Gender beliefs in medical students.

Eur J Intern Med 2017 06 27;41:e24. Epub 2017 Feb 27.

European Medical Students' Association, Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.ejim.2017.02.021DOI Listing
June 2017

Health-care access of transgender people: a medical student approach.

Lancet Diabetes Endocrinol 2016 05;4(5):388-9

Department for Internal Affairs, European Medical Students' Association, B-1040 Brussels, Belgium.

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http://dx.doi.org/10.1016/S2213-8587(16)30003-1DOI Listing
May 2016

Training: Common doctorates across Europe.

Nature 2015 Dec;528(7582):333

European Medical Students' Association, Brussels, Belgium.

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http://dx.doi.org/10.1038/528333cDOI Listing
December 2015