Publications by authors named "Benedikt M Kessler"

235 Publications

Correction: The deubiquitylase USP9X controls ribosomal stalling.

Authors:
Anne Clancy Claire Heride Adán Pinto-Fernández Hannah Elcocks Andreas Kallinos Katherine J Kayser-Bricker Weiping Wang Victoria Smith Simon Davis Shawn Fessler Crystal McKinnon Marie Katz Tim Hammonds Neil P Jones Jonathan O'Connell Bruce Follows Steven Mischke Justin A Caravella Stephanos Ioannidis Christopher Dinsmore Sunkyu Kim Axel Behrens David Komander Benedikt M Kessler Sylvie Urbé Michael J Clague

J Cell Biol 2021 Mar;220(3)

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March 2021

The deubiquitylase USP9X controls ribosomal stalling.

Authors:
Anne Clancy Claire Heride Adán Pinto-Fernández Hannah Elcocks Andreas Kallinos Katherine J Kayser-Bricker Weiping Wang Victoria Smith Simon Davis Shawn Fessler Crystal McKinnon Marie Katz Tim Hammonds Neil P Jones Jonathan O'Connell Bruce Follows Steven Mischke Justin A Caravella Stephanos Ioannidis Christopher Dinsmore Sunkyu Kim Axel Behrens David Komander Benedikt M Kessler Sylvie Urbé Michael J Clague

J Cell Biol 2021 Mar;220(3)

Department of Molecular Physiology and Cell Signaling, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.

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March 2021

The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.

Authors:
Ann-Marie K Shorrocks Samuel E Jones Kaima Tsukada Carl A Morrow Zoulikha Belblidia Johanna Shen Iolanda Vendrell Roman Fischer Benedikt M Kessler Andrew N Blackford

Nat Commun 2021 01 26;12(1):585. Epub 2021 Jan 26.

MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.

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January 2021

DUB esterase activity further decodes ubiquitin's enigma.

Authors:
Benedikt M Kessler

Proc Natl Acad Sci U S A 2021 Feb;118(6)

Target Discovery Institute, Centre for Medicines Discovery, Chinese Academy for Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom

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February 2021

Sex Peptide controls the assembly of lipid microcarriers in seminal fluid.

Authors:
S Mark Wainwright Ben R Hopkins Cláudia C Mendes Aashika Sekar Benjamin Kroeger Josephine E E U Hellberg Shih-Jung Fan Abigail Pavey Pauline P Marie Aaron Leiblich Irem Sepil Philip D Charles Marie L Thézénas Roman Fischer Benedikt M Kessler Carina Gandy Laura Corrigan Rachel Patel Stuart Wigby John F Morris Deborah C I Goberdhan Clive Wilson

Proc Natl Acad Sci U S A 2021 Feb;118(5)

Department of Physiology, Anatomy and Genetics, University of Oxford, OX1 3QX Oxford, United Kingdom;

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February 2021

Detection and quantification of novel C-terminal TDP-43 fragments in ALS-TDP.

Authors:
Emily Feneberg Philip D Charles Mattéa J Finelli Connor Scott Benedikt M Kessler Roman Fischer Olaf Ansorge Elizabeth Gray Kevin Talbot Martin R Turner

Brain Pathol 2020 Dec 10:e12923. Epub 2020 Dec 10.

Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.

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December 2020

Subclinical effects of remote ischaemic conditioning in human kidney transplants revealed by quantitative proteomics.

Authors:
Adam M Thorne Honglei Huang Darragh P O'Brien Marco Eijken Nicoline Valentina Krogstrup Rikke Norregaard Bjarne Møller Rutger J Ploeg Bente Jespersen Benedikt M Kessler

Clin Proteomics 2020 Nov 2;17(1):39. Epub 2020 Nov 2.

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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November 2020

Dual role of ER stress in response to metabolic co-targeting and radiosensitivity in head and neck cancer cells.

Authors:
Oleg Chen Friederike Manig Loreen Lehmann Nagwa Sorour Steffen Löck Zhanru Yu Anna Dubrovska Michael Baumann Benedikt M Kessler Oleh Stasyk Leoni A Kunz-Schughart

Cell Mol Life Sci 2020 Nov 23. Epub 2020 Nov 23.

OncoRay, National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden and Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstraße 74, 01307, Dresden, Germany.

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November 2020

Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity.

Authors:
Adan Pinto-Fernandez Mariolina Salio Tom Partridge Jianzhou Chen George Vere Helene Greenwood Cyriel Sebastiaan Olie Andreas Damianou Hannah Claire Scott Henry Jack Pegg Alessandra Chiarenza Laura Díaz-Saez Paul Smith Claudia Gonzalez-Lopez Bhavisha Patel Emma Anderton Neil Jones Tim R Hammonds Kilian Huber Ruth Muschel Persephone Borrow Vincenzo Cerundolo Benedikt M Kessler

Br J Cancer 2021 Feb 20;124(4):817-830. Epub 2020 Nov 20.

TDI Mass Spectrometry Laboratory, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, Roosevelt Drive, Oxford, OX3 7FZ, UK.

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February 2021

Ubiquitomics: An Overview and Future.

Authors:
George Vere Rachel Kealy Benedikt M Kessler Adan Pinto-Fernandez

Biomolecules 2020 10 17;10(10). Epub 2020 Oct 17.

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.

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October 2020

Cytoskeletal disorganization underlies PABPN1-mediated myogenic disability.

Authors:
Cyriel Sebastiaan Olie Erik van der Wal Cikes Domagoj Loes Maton Jessica C de Greef I-Hsuan Lin Yi-Fan Chen Elsayad Kareem Josef M Penninger Benedikt M Kessler Vered Raz

Sci Rep 2020 10 19;10(1):17621. Epub 2020 Oct 19.

Human Genetics Department, Leiden University Medical Center, Leiden, The Netherlands.

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October 2020

Urine recirculation prolongs normothermic kidney perfusion via more optimal metabolic homeostasis-a proteomics study.

Authors:
Annemarie Weissenbacher Honglei Huang Tomas Surik Maria L Lo Faro Rutger J Ploeg Constantin C Coussios Peter J Friend Benedikt M Kessler

Am J Transplant 2020 Oct 5. Epub 2020 Oct 5.

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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October 2020

A Functional Genomic Screen Identifies the Deubiquitinase USP11 as a Novel Transcriptional Regulator of ERα in Breast Cancer.

Authors:
Lisa Dwane Aisling E O'Connor Sudipto Das Bruce Moran Laoighse Mulrane Adan Pinto-Fernandez Elspeth Ward Anna M Blümel Brenton L Cavanagh Brian Mooney Annette M Dirac Karin Jirström Benedikt M Kessler Tríona Ní Chonghaile René Bernards William M Gallagher Darran P O'Connor

Cancer Res 2020 11 1;80(22):5076-5088. Epub 2020 Oct 1.

School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons Ireland, Dublin, Ireland.

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November 2020

Distinct contributions of DNA methylation and histone acetylation to the genomic occupancy of transcription factors.

Authors:
Martin Cusack Hamish W King Paolo Spingardi Benedikt M Kessler Robert J Klose Skirmantas Kriaucionis

Genome Res 2020 Oct 22;30(10):1393-1406. Epub 2020 Sep 22.

Ludwig Institute for Cancer Research, University of Oxford, Oxford, OX3 7DQ, United Kingdom;

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October 2020

Broad and strong memory CD4 and CD8 T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19.

Authors:
Yanchun Peng Alexander J Mentzer Guihai Liu Xuan Yao Zixi Yin Danning Dong Wanwisa Dejnirattisai Timothy Rostron Piyada Supasa Chang Liu César López-Camacho Jose Slon-Campos Yuguang Zhao David I Stuart Guido C Paesen Jonathan M Grimes Alfred A Antson Oliver W Bayfield Dorothy E D P Hawkins De-Sheng Ker Beibei Wang Lance Turtle Krishanthi Subramaniam Paul Thomson Ping Zhang Christina Dold Jeremy Ratcliff Peter Simmonds Thushan de Silva Paul Sopp Dannielle Wellington Ushani Rajapaksa Yi-Ling Chen Mariolina Salio Giorgio Napolitani Wayne Paes Persephone Borrow Benedikt M Kessler Jeremy W Fry Nikolai F Schwabe Malcolm G Semple J Kenneth Baillie Shona C Moore Peter J M Openshaw M Azim Ansari Susanna Dunachie Eleanor Barnes John Frater Georgina Kerr Philip Goulder Teresa Lockett Robert Levin Yonghong Zhang Ronghua Jing Ling-Pei Ho Richard J Cornall Christopher P Conlon Paul Klenerman Gavin R Screaton Juthathip Mongkolsapaya Andrew McMichael Julian C Knight Graham Ogg Tao Dong

Nat Immunol 2020 11 4;21(11):1336-1345. Epub 2020 Sep 4.

MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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November 2020

CSF extracellular vesicle proteomics demonstrates altered protein homeostasis in amyotrophic lateral sclerosis.

Authors:
Alexander G Thompson Elizabeth Gray Imre Mäger Marie-Laëtitia Thézénas Philip D Charles Kevin Talbot Roman Fischer Benedikt M Kessler Mathew Wood Martin R Turner

Clin Proteomics 2020 17;17:31. Epub 2020 Aug 17.

Nuffield Department of Clinical Neurosciences, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Oxford, OX3 9DU UK.

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August 2020

An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress.

Authors:
Emily Feneberg David Gordon Alexander G Thompson Mattéa J Finelli Ruxandra Dafinca Ana Candalija Philip D Charles Imre Mäger Matthew J Wood Roman Fischer Benedikt M Kessler Elizabeth Gray Martin R Turner Kevin Talbot

Neurobiol Dis 2020 10 13;144:105050. Epub 2020 Aug 13.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, United Kingdom; Lead Contact. Electronic address:

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October 2020

USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation.

Authors:
Emma V Rusilowicz-Jones Jane Jardine Andreas Kallinos Adan Pinto-Fernandez Franziska Guenther Mariacarmela Giurrandino Francesco G Barone Katy McCarron Christopher J Burke Alejandro Murad Aitor Martinez Elena Marcassa Malte Gersch Alexandre J Buckmelter Katherine J Kayser-Bricker Frederic Lamoliatte Akshada Gajbhiye Simon Davis Hannah C Scott Emma Murphy Katherine England Heather Mortiboys David Komander Matthias Trost Benedikt M Kessler Stephanos Ioannidis Michael K Ahlijanian Sylvie Urbé Michael J Clague

Life Sci Alliance 2020 08 7;3(8). Epub 2020 Jul 7.

Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK

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August 2020

Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling.

Authors:
Emma J Fenech Federica Lari Philip D Charles Roman Fischer Marie Laétitia-Thézénas Katrin Bagola Adrienne W Paton James C Paton Mads Gyrd-Hansen Benedikt M Kessler John C Christianson

Elife 2020 07 2;9. Epub 2020 Jul 2.

Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

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July 2020

Male reproductive aging arises via multifaceted mating-dependent sperm and seminal proteome declines, but is postponable in .

Authors:
Irem Sepil Ben R Hopkins Rebecca Dean Eleanor Bath Solomon Friedman Ben Swanson Harrison J Ostridge Lucy Harper Norene A Buehner Mariana F Wolfner Rebecca Konietzny Marie-Laëtitia Thézénas Elizabeth Sandham Philip D Charles Roman Fischer Josefa Steinhauer Benedikt M Kessler Stuart Wigby

Proc Natl Acad Sci U S A 2020 07 1;117(29):17094-17103. Epub 2020 Jul 1.

Department of Zoology, University of Oxford, OX1 3SZ Oxford, United Kingdom.

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July 2020

Editorial: Probing the Ubiquitin Landscape.

Authors:
Monique P C Mulder Zhihao Zhuang Lei Liu Benedikt M Kessler Huib Ovaa

Front Chem 2020 20;8:449. Epub 2020 May 20.

Department of Cell and Chemical Biology, Oncode Institute, Leiden University Medical Centre, Leiden, Netherlands.

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May 2020

Author Correction: Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions.

Authors:
Marie-Laëtitia Thézénas Bianca De Leo Alexis Laux-Biehlmann Cemsel Bafligil Bernd Elger Thomas Tapmeier Karl Morten Nilufer Rahmioglu Stephanie G Dakin Philip Charles Fernando Estrada Martinez Graham Steers Oliver M Fischer Joerg Mueller Holger Hess-Stumpp Andreas Steinmeyer Sanjiv Manek Krina T Zondervan Stephen Kennedy Christian M Becker Catherine Shang Thomas M Zollner Benedikt M Kessler Udo Oppermann

Sci Rep 2020 Mar 24;10(1):5665. Epub 2020 Mar 24.

Botnar Research Centre, NIHR Biomedical Research Unit Oxford, Nuffield Department of Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7LD, UK.

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March 2020

TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts.

Authors:
John Fielden Katherine Wiseman Ignacio Torrecilla Shudong Li Samuel Hume Shih-Chieh Chiang Annamaria Ruggiano Abhay Narayan Singh Raimundo Freire Sylvana Hassanieh Enric Domingo Iolanda Vendrell Roman Fischer Benedikt M Kessler Timothy S Maughan Sherif F El-Khamisy Kristijan Ramadan

Nat Commun 2020 03 9;11(1):1274. Epub 2020 Mar 9.

Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, OX3 7DQ, UK.

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March 2020

Re-Evaluating the Mechanism of Action of α,β-Unsaturated Carbonyl DUB Inhibitors b-AP15 and VLX1570: A Paradigmatic Example of Unspecific Protein Cross-linking with Michael Acceptor Motif-Containing Drugs.

Authors:
Jennifer A Ward Adan Pinto-Fernandez Loïc Cornelissen Sarah Bonham Laura Díaz-Sáez Olivier Riant Kilian V M Huber Benedikt M Kessler Olivier Feron Edward W Tate

J Med Chem 2020 04 19;63(7):3756-3762. Epub 2020 Mar 19.

Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, London W12 0BZ, U.K.

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April 2020

Characterization of exosomes in peritoneal fluid of endometriosis patients.

Authors:
Hannah M Nazri Maria Imran Roman Fischer Raphael Heilig Sanjiv Manek Rebecca A Dragovic Benedikt M Kessler Krina T Zondervan Thomas T Tapmeier Christian M Becker

Fertil Steril 2020 02;113(2):364-373.e2

Endometriosis CaRe Centre, Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, United Kingdom.

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February 2020

Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions.

Authors:
Marie-Laëtitia Thézénas Bianca De Leo Alexis Laux-Biehlmann Cemsel Bafligil Bernd Elger Thomas Tapmeier Karl Morten Nilufer Rahmioglu Stephanie G Dakin Philip Charles Fernando Estrada Martinez Graham Steers Oliver M Fischer Joerg Mueller Holger Hess-Stumpp Andreas Steinmeyer Sanjiv Manek Krina T Zondervan Stephen Kennedy Christian M Becker Catherine Shang Thomas M Zollner Benedikt M Kessler Udo Oppermann

Sci Rep 2020 01 30;10(1):1495. Epub 2020 Jan 30.

Botnar Research Centre, NIHR Biomedical Research Unit Oxford, Nuffield Department of Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7LD, UK.

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January 2020

BMP signaling inhibition in secondary cells remodels the seminal proteome and self and rival ejaculate functions.

Authors:
Ben R Hopkins Irem Sepil Sarah Bonham Thomas Miller Philip D Charles Roman Fischer Benedikt M Kessler Clive Wilson Stuart Wigby

Proc Natl Acad Sci U S A 2019 12 18;116(49):24719-24728. Epub 2019 Nov 18.

Edward Grey Institute, Department of Zoology, University of Oxford, OX1 3PS Oxford, United Kingdom.

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December 2019

First Report on Ex Vivo Delivery of Paracrine Active Human Mesenchymal Stromal Cells to Liver Grafts During Machine Perfusion.

Authors:
Monique M A Verstegen Laura Mezzanotte R Yanto Ridwan Kairong Wang Jubi de Haan Ivo J Schurink Jésus M Sierra Parraga Martin Hoogduijn Benedikt M Kessler Honglei Huang Sean R R Hall Jan N M Ijzermans Clemens W G M Löwik Luc J W van der Laan Jeroen de Jonge

Transplantation 2020 01;104(1):e5-e7

Department of Surgery, Erasmus MC, University Medical Center Rotterdam, the Netherlands.

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January 2020

Comprehensive Landscape of Active Deubiquitinating Enzymes Profiled by Advanced Chemoproteomics.

Authors:
Adán Pinto-Fernández Simon Davis Abigail B Schofield Hannah C Scott Ping Zhang Eidarus Salah Sebastian Mathea Philip D Charles Andreas Damianou Gareth Bond Roman Fischer Benedikt M Kessler

Front Chem 2019 29;7:592. Epub 2019 Aug 29.

University of Oxford, Oxford, United Kingdom.

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August 2019

Proteomics analysis of the matrisome from MC38 experimental mouse liver metastases.

Authors:
Arseniy E Yuzhalin Su Yin Lim Alex N Gordon-Weeks Roman Fischer Benedikt M Kessler Dihua Yu Ruth J Muschel

Am J Physiol Gastrointest Liver Physiol 2019 11 23;317(5):G625-G639. Epub 2019 Sep 23.

Cancer Research United Kingdom/Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.

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November 2019