Benedikt M Kessler

Benedikt M Kessler

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Benedikt M Kessler

Benedikt M Kessler

Publications by authors named "Benedikt M Kessler"

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First Report on Ex Vivo Delivery of Paracrine Active Human Mesenchymal Stromal Cells to Liver Grafts During Machine Perfusion.

Authors:
Monique M A Verstegen Laura Mezzanotte R Yanto Ridwan Kairong Wang Jubi de Haan Ivo J Schurink Jésus M Sierra Parraga Martin Hoogduijn Benedikt M Kessler Honglei Huang Sean R R Hall Jan N M Ijzermans Clemens W G M Löwik Luc J W van der Laan Jeroen de Jonge

Transplantation 2020 Jan;104(1):e5-e7

Department of Surgery, Erasmus MC, University Medical Center Rotterdam, the Netherlands.

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http://dx.doi.org/10.1097/TP.0000000000002986DOI Listing
January 2020

Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions.

Authors:
Marie-Laëtitia Thézénas Bianca De Leo Alexis Laux-Biehlmann Cemsel Bafligil Bernd Elger Thomas Tapmeier Karl Morten Nilufer Rahmioglu Stephanie G Dakin Philip Charles Fernando Estrada Martinez Graham Steers Oliver M Fischer Joerg Mueller Holger Hess-Stumpp Andreas Steinmeyer Sanjiv Manek Krina T Zondervan Stephen Kennedy Christian M Becker Catherine Shang Thomas M Zollner Benedikt M Kessler Udo Oppermann

Sci Rep 2020 Jan 30;10(1):1495. Epub 2020 Jan 30.

Botnar Research Centre, NIHR Biomedical Research Unit Oxford, Nuffield Department of Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7LD, UK.

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http://dx.doi.org/10.1038/s41598-020-58362-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992811PMC
January 2020

BMP signaling inhibition in secondary cells remodels the seminal proteome and self and rival ejaculate functions.

Authors:
Ben R Hopkins Irem Sepil Sarah Bonham Thomas Miller Philip D Charles Roman Fischer Benedikt M Kessler Clive Wilson Stuart Wigby

Proc Natl Acad Sci U S A 2019 Dec 18;116(49):24719-24728. Epub 2019 Nov 18.

Edward Grey Institute, Department of Zoology, University of Oxford, OX1 3PS Oxford, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1914491116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900634PMC
December 2019

Proteomics analysis of the matrisome from MC38 experimental mouse liver metastases.

Authors:
Arseniy E Yuzhalin Su Yin Lim Alex N Gordon-Weeks Roman Fischer Benedikt M Kessler Dihua Yu Ruth J Muschel

Am J Physiol Gastrointest Liver Physiol 2019 Nov 23;317(5):G625-G639. Epub 2019 Sep 23.

Cancer Research United Kingdom/Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1152/ajpgi.00014.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879896PMC
November 2019

E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition.

Authors:
Kamila Burdova Hongbin Yang Roberta Faedda Samuel Hume Jagat Chauhan Daniel Ebner Benedikt M Kessler Iolanda Vendrell David H Drewry Carrow I Wells Stephanie B Hatch Grigory L Dianov Francesca M Buffa Vincenzo D'Angiolella

EMBO J 2019 10 19;38(20):e101443. Epub 2019 Aug 19.

Department of Oncology, Medical Research Council Institute for Radiation Oncology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.15252/embj.2018101443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792013PMC
October 2019

Divergent allocation of sperm and the seminal proteome along a competition gradient in .

Authors:
Ben R Hopkins Irem Sepil Marie-Laëtitia Thézénas James F Craig Thomas Miller Philip D Charles Roman Fischer Benedikt M Kessler Amanda Bretman Tommaso Pizzari Stuart Wigby

Proc Natl Acad Sci U S A 2019 Sep 20;116(36):17925-17933. Epub 2019 Aug 20.

Edward Grey Institute, Department of Zoology, University of Oxford, OX1 3PS Oxford, United Kingdom.

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http://www.pnas.org/lookup/doi/10.1073/pnas.1906149116
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http://dx.doi.org/10.1073/pnas.1906149116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731677PMC
September 2019

Regulation of the endosomal SNX27-retromer by OTULIN.

Authors:
Aurelia Stangl Paul R Elliott Adan Pinto-Fernandez Sarah Bonham Luke Harrison Annalisa Schaub Kerstin Kutzner Kirstin Keusekotten Paul T Pfluger Farid El Oualid Benedikt M Kessler David Komander Daniel Krappmann

Nat Commun 2019 09 20;10(1):4320. Epub 2019 Sep 20.

Research Unit Cellular Signal Integration, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München, Ingolstaedter Landstrasse 1, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1038/s41467-019-12309-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754446PMC
September 2019

A Novel Role for Triglyceride Metabolism in Foxp3 Expression.

Authors:
Duncan Howie Annemieke Ten Bokum Stephen Paul Cobbold Zhanru Yu Benedikt M Kessler Herman Waldmann

Front Immunol 2019 13;10:1860. Epub 2019 Aug 13.

Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2019.01860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701200PMC
August 2019

Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T cells.

Authors:
David G Saliba Pablo F Céspedes-Donoso Štefan Bálint Ewoud B Compeer Kseniya Korobchevskaya Salvatore Valvo Viveka Mayya Audun Kvalvaag Yanchun Peng Tao Dong Maria-Laura Tognoli Eric O'Neill Sarah Bonham Roman Fischer Benedikt M Kessler Michael L Dustin

Elife 2019 08 30;8. Epub 2019 Aug 30.

Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.7554/eLife.47528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748831PMC
August 2019

Comprehensive Landscape of Active Deubiquitinating Enzymes Profiled by Advanced Chemoproteomics.

Authors:
Adán Pinto-Fernández Simon Davis Abigail B Schofield Hannah C Scott Ping Zhang Eidarus Salah Sebastian Mathea Philip D Charles Andreas Damianou Gareth Bond Roman Fischer Benedikt M Kessler

Front Chem 2019 29;7:592. Epub 2019 Aug 29.

University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.3389/fchem.2019.00592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727631PMC
August 2019

Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism.

Authors:
Alessandro Valli Matteo Morotti Christos E Zois Patrick K Albers Tomoyoshi Soga Katharina Feldinger Roman Fischer Martin Frejno Alan McIntyre Esther Bridges Syed Haider Francesca M Buffa Dilair Baban Miguel Rodriguez Oscar Yanes Hannah J Whittington Hannah A Lake Sevasti Zervou Craig A Lygate Benedikt M Kessler Adrian L Harris

Mol Cancer Res 2019 07 18;17(7):1531-1544. Epub 2019 Mar 18.

Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1158/1541-7786.MCR-18-0315DOI Listing
July 2019

Improved profiling of polyamines using two-dimensional gas chromatography mass spectrometry.

Authors:
Zhanru Yu Honglei Huang Hanlin Zhang Benedikt M Kessler

Talanta 2019 Jul 18;199:184-188. Epub 2019 Feb 18.

TDI Mass Spectrometry Laboratory, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00399140193020
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http://dx.doi.org/10.1016/j.talanta.2019.02.062DOI Listing
July 2019

Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation.

Authors:
Jade D Bailey Marina Diotallevi Thomas Nicol Eileen McNeill Andrew Shaw Surawee Chuaiphichai Ashley Hale Anna Starr Manasi Nandi Elena Stylianou Helen McShane Simon Davis Roman Fischer Benedikt M Kessler James McCullagh Keith M Channon Mark J Crabtree

Cell Rep 2019 Jul;28(1):218-230.e7

BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616861PMC
July 2019

Ataxin-3 Links NOD2 and TLR2 Mediated Innate Immune Sensing and Metabolism in Myeloid Cells.

Authors:
Thomas P Chapman Daniele Corridoni Seiji Shiraishi Sumeet Pandey Anna Aulicino Simon Wigfield Maria do Carmo Costa Marie-Laëtitia Thézénas Henry Paulson Roman Fischer Benedikt M Kessler Alison Simmons

Front Immunol 2019 19;10:1495. Epub 2019 Jul 19.

MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2019.01495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659470PMC
July 2019

Discrimination Between Human Leukocyte Antigen Class I-Bound and Co-Purified HIV-Derived Peptides in Immunopeptidomics Workflows.

Authors:
Thomas Partridge Annalisa Nicastri Anna E Kliszczak Louis-Marie Yindom Benedikt M Kessler Nicola Ternette Persephone Borrow

Front Immunol 2018 27;9:912. Epub 2018 Apr 27.

Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

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http://journal.frontiersin.org/article/10.3389/fimmu.2018.00
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http://dx.doi.org/10.3389/fimmu.2018.00912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946011PMC
June 2019

MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis.

Authors:
Pia-Amata Leimbacher Samuel E Jones Ann-Marie K Shorrocks Mara de Marco Zompit Matthew Day Jordy Blaauwendraad Diana Bundschuh Sarah Bonham Roman Fischer Daniel Fink Benedikt M Kessler Antony W Oliver Laurence H Pearl Andrew N Blackford Manuel Stucki

Mol Cell 2019 05 18;74(3):571-583.e8. Epub 2019 Mar 18.

Department of Gynecology, University Hospital and University of Zurich, Wagistrasse 14, 8952 Schlieren, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509287PMC
May 2019

Capturing the dynamics of genome replication on individual ultra-long nanopore sequence reads.

Authors:
Carolin A Müller Michael A Boemo Paolo Spingardi Benedikt M Kessler Skirmantas Kriaucionis Jared T Simpson Conrad A Nieduszynski

Nat Methods 2019 05 22;16(5):429-436. Epub 2019 Apr 22.

Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/s41592-019-0394-yDOI Listing
May 2019

Molecular insights into an ancient form of Paget's disease of bone.

Authors:
Barry Shaw Carla L Burrell Darrell Green Ana Navarro-Martinez Daniel Scott Anna Daroszewska Rob van 't Hof Lynn Smith Frank Hargrave Sharad Mistry Andrew Bottrill Benedikt M Kessler Roman Fischer Archana Singh Tamas Dalmay William D Fraser Kirstin Henneberger Turi King Silvia Gonzalez Robert Layfield

Proc Natl Acad Sci U S A 2019 May 29;116(21):10463-10472. Epub 2019 Apr 29.

School of Life Sciences, University of Nottingham, NG7 2UH Nottingham, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1820556116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535003PMC
May 2019

Quantitative Proteomics Identification of Seminal Fluid Proteins in Male .

Authors:
Irem Sepil Ben R Hopkins Rebecca Dean Marie-Laëtitia Thézénas Philip D Charles Rebecca Konietzny Roman Fischer Benedikt M Kessler Stuart Wigby

Mol Cell Proteomics 2019 03 4;18(Suppl 1):S46-S58. Epub 2018 Oct 4.

From the ‡Edward Grey Institute, Department of Zoology, University of Oxford, Oxford, UK.

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http://www.mcponline.org/lookup/doi/10.1074/mcp.RA118.000831
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http://dx.doi.org/10.1074/mcp.RA118.000831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427238PMC
March 2019

Colonic epithelial cell diversity in health and inflammatory bowel disease.

Authors:
Kaushal Parikh Agne Antanaviciute David Fawkner-Corbett Marta Jagielowicz Anna Aulicino Christoffer Lagerholm Simon Davis James Kinchen Hannah H Chen Nasullah Khalid Alham Neil Ashley Errin Johnson Philip Hublitz Leyuan Bao Joanna Lukomska Rajinder Singh Andev Elisabet Björklund Benedikt M Kessler Roman Fischer Robert Goldin Hashem Koohy Alison Simmons

Nature 2019 03 27;567(7746):49-55. Epub 2019 Feb 27.

Medical Research Council (MRC) Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine (WIMM), John Radcliffe Hospital, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/s41586-019-0992-yDOI Listing
March 2019

From herbal small RNAs to one medicine.

Authors:
Chao Ji Skirmantas Kriaucionis Benedikt M Kessler Chengyu Jiang

Sci China Life Sci 2019 03 1;62(3):285-287. Epub 2019 Mar 1.

State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS-Oxford Institute, Chinese Academy of Medical Sciences, Department of Biochemistry, Peking Union Medical College, Beijing, 100005, China.

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http://dx.doi.org/10.1007/s11427-019-9513-yDOI Listing
March 2019

USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7.

Authors:
Aysegul Sapmaz Ilana Berlin Erik Bos Ruud H Wijdeven Hans Janssen Rebecca Konietzny Jimmy J Akkermans Ayse E Erson-Bensan Roman I Koning Benedikt M Kessler Jacques Neefjes Huib Ovaa

Nat Commun 2019 03 29;10(1):1454. Epub 2019 Mar 29.

Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands.

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http://dx.doi.org/10.1038/s41467-019-09437-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440979PMC
March 2019

Deacetylation Inhibition Reverses PABPN1-Dependent Muscle Wasting.

Authors:
Cyriel S Olie Muhammad Riaz Rebecca Konietzny Philip D Charles Adan Pinto-Fernandez Szymon M Kiełbasa A Aartsma-Rus Jelle J Goeman Benedikt M Kessler Vered Raz

iScience 2019 Feb 22;12:318-332. Epub 2019 Jan 22.

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2019.01.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370712PMC
February 2019

The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis.

Authors:
Norbert Volkmar Maria-Laetitia Thezenas Sharon M Louie Szymon Juszkiewicz Daniel K Nomura Ramanujan S Hegde Benedikt M Kessler John C Christianson

J Cell Sci 2019 01 16;132(2). Epub 2019 Jan 16.

Ludwig Institute for Cancer Research, University of Oxford, ORCRB, Headington, Oxford, OX3 7DQ, UK

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http://jcs.biologists.org/lookup/doi/10.1242/jcs.223453
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http://dx.doi.org/10.1242/jcs.223453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362398PMC
January 2019

An Activity-Based Probe Targeting Non-Catalytic, Highly Conserved Amino Acid Residues within Bromodomains.

Authors:
Melissa D'Ascenzio Kathryn M Pugh Rebecca Konietzny Georgina Berridge Cynthia Tallant Shaima Hashem Octovia Monteiro Jason R Thomas Markus Schirle Stefan Knapp Brian Marsden Oleg Fedorov Chas Bountra Benedikt M Kessler Paul E Brennan

Angew Chem Int Ed Engl 2019 Jan 27;58(4):1007-1012. Epub 2018 Dec 27.

Structural Genomic Consortium (SGC), University of Oxford, Oxford, OX3 7DQ, UK.

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http://doi.wiley.com/10.1002/anie.201807825
Publisher Site
http://dx.doi.org/10.1002/anie.201807825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492141PMC
January 2019

Human Platelet Protein Ubiquitylation and Changes following GPVI Activation.

Authors:
Amanda J Unsworth Izabela Bombik Adan Pinto-Fernandez Joanna F McGouran Rebecca Konietzny René P Zahedi Steve P Watson Benedikt M Kessler Catherine J Pears

Thromb Haemost 2019 Jan 31;119(1):104-116. Epub 2018 Dec 31.

Department of Biochemistry, University of Oxford, Oxford, United Kingdom.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1676344
Publisher Site
http://dx.doi.org/10.1055/s-0038-1676344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327716PMC
January 2019

UFLC-Derived CSF Extracellular Vesicle Origin and Proteome.

Authors:
Alexander G Thompson Elizabeth Gray Imre Mager Roman Fischer Marie-Laëtitia Thézénas Philip D Charles Kevin Talbot Samir El Andaloussi Benedikt M Kessler Matthew Wood Martin R Turner

Proteomics 2018 12 10;18(24):e1800257. Epub 2018 Dec 10.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.

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http://doi.wiley.com/10.1002/pmic.201800257
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http://dx.doi.org/10.1002/pmic.201800257DOI Listing
December 2018

The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage.

Authors:
Ryotaro Nishi Paul W G Wijnhoven Yusuke Kimura Misaki Matsui Rebecca Konietzny Qian Wu Keisuke Nakamura Tom L Blundell Benedikt M Kessler

Sci Rep 2018 12 17;8(1):17891. Epub 2018 Dec 17.

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ, United Kingdom.

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http://dx.doi.org/10.1038/s41598-018-36235-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297141PMC
December 2018

Publisher Correction: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases.

Authors:
Suzana Markolovic Qinqin Zhuang Sarah E Wilkins Charlotte D Eaton Martine I Abboud Maximiliano J Katz Helen E McNeil Robert K Leśniak Charlotte Hall Weston B Struwe Rebecca Konietzny Simon Davis Ming Yang Wei Ge Justin L P Benesch Benedikt M Kessler Peter J Ratcliffe Matthew E Cockman Roman Fischer Pablo Wappner Rasheduzzaman Chowdhury Mathew L Coleman Christopher J Schofield

Nat Chem Biol 2018 Oct;14(10):988

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/s41589-018-0104-6DOI Listing
October 2018

Identification of UHRF2 as a novel DNA interstrand crosslink sensor protein.

Authors:
Anna Motnenko Chih-Chao Liang Di Yang David Lopez-Martinez Yasunaga Yoshikawa Bao Zhan Katherine E Ward Jiayang Tian Wilhelm Haas Paolo Spingardi Benedikt M Kessler Skirmantas Kriaucionis Steven P Gygi Martin A Cohn

PLoS Genet 2018 10 18;14(10):e1007643. Epub 2018 Oct 18.

Department of Biochemistry, University of Oxford, Oxford, United Kingdom.

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http://dx.plos.org/10.1371/journal.pgen.1007643
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http://dx.doi.org/10.1371/journal.pgen.1007643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193622PMC
October 2018

A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes.

Authors:
Tianyi Zhang Guifeng Wei Christopher J Millard Roman Fischer Rebecca Konietzny Benedikt M Kessler John W R Schwabe Neil Brockdorff

Nat Commun 2018 09 18;9(1):3798. Epub 2018 Sep 18.

Developmental Epigenetics, Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, United Kingdom.

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http://dx.doi.org/10.1038/s41467-018-06235-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143588PMC
September 2018

Proteomic profiling of the plasma of Gambian children with cerebral malaria.

Authors:
Ehab M Moussa Honglei Huang Marie L Thézénas Roman Fischer Abhinay Ramaprasad Fatou Sisay-Joof Muminatou Jallow Arnab Pain Dominic Kwiatkowski Benedikt M Kessler Climent Casals-Pascual

Malar J 2018 Sep 24;17(1):337. Epub 2018 Sep 24.

Wellcome Trust Centre for Human Genetics, Oxford, UK.

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12936-018-2487-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154937PMC
September 2018

Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation.

Authors:
Jade Bailey Simon Davis Andrew Shaw Marina Diotallevi Roman Fischer Matthew A Benson Hanneng Zhu James Brown Shoumo Bhattacharya Benedikt M Kessler Keith M Channon Mark J Crabtree

Sci Rep 2018 09 25;8(1):14310. Epub 2018 Sep 25.

BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.

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http://www.nature.com/articles/s41598-018-32481-4
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http://dx.doi.org/10.1038/s41598-018-32481-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156325PMC
September 2018

β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression.

Authors:
Ioanna Mavrommati Roberta Faedda Giovanni Galasso Jie Li Kamila Burdova Roman Fischer Benedikt M Kessler Zunamys I Carrero Daniele Guardavaccaro Michele Pagano Vincenzo D'Angiolella

Cell Rep 2018 09;24(13):3404-3412

Cancer Research UK and Medical Research Council Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.08.076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172692PMC
September 2018

53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ.

Authors:
Hind Ghezraoui Catarina Oliveira Jordan R Becker Kirstin Bilham Daniela Moralli Consuelo Anzilotti Roman Fischer Mukta Deobagkar-Lele Maria Sanchiz-Calvo Elena Fueyo-Marcos Sarah Bonham Benedikt M Kessler Sven Rottenberg Richard J Cornall Catherine M Green J Ross Chapman

Nature 2018 08 25;560(7716):122-127. Epub 2018 Jul 25.

Genome Integrity Laboratory, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/s41586-018-0362-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989217PMC
August 2018

Development and validation of response markers to predict survival and pleurodesis success in patients with malignant pleural effusion (PROMISE): a multicohort analysis.

Authors:
Ioannis Psallidas Nikolaos I Kanellakis Stephen Gerry Marie Laëtitia Thézénas Philip D Charles Anastasia Samsonova Herbert B Schiller Roman Fischer Rachelle Asciak Robert J Hallifax Rachel Mercer Melissa Dobson Tao Dong Ian D Pavord Gary S Collins Benedikt M Kessler Harvey I Pass Nick Maskell Georgios T Stathopoulos Najib M Rahman

Lancet Oncol 2018 07 13;19(7):930-939. Epub 2018 Jun 13.

Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Laboratory of Pleural and Lung Cancer Translational Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Oxford Respiratory Trials Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK; National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/S1470-2045(18)30294-8DOI Listing
July 2018

The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases.

Authors:
Suzana Markolovic Qinqin Zhuang Sarah E Wilkins Charlotte D Eaton Martine I Abboud Maximiliano J Katz Helen E McNeil Robert K Leśniak Charlotte Hall Weston B Struwe Rebecca Konietzny Simon Davis Ming Yang Wei Ge Justin L P Benesch Benedikt M Kessler Peter J Ratcliffe Matthew E Cockman Roman Fischer Pablo Wappner Rasheduzzaman Chowdhury Mathew L Coleman Christopher J Schofield

Nat Chem Biol 2018 07 18;14(7):688-695. Epub 2018 Jun 18.

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/s41589-018-0071-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027965PMC
July 2018

Immunopeptidomic Profiling of HLA-A2-Positive Triple Negative Breast Cancer Identifies Potential Immunotherapy Target Antigens.

Authors:
Nicola Ternette Marloes J M Olde Nordkamp Julius Müller Amanda P Anderson Annalisa Nicastri Adrian V S Hill Benedikt M Kessler Demin Li

Proteomics 2018 06;18(12):e1700465

Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.

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http://dx.doi.org/10.1002/pmic.201700465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032843PMC
June 2018

Proteo-metabolomics reveals compensation between ischemic and non-injured contralateral kidneys after reperfusion.

Authors:
Honglei Huang Leon F A van Dullemen Mohammed Z Akhtar Maria-Letizia Lo Faro Zhanru Yu Alessandro Valli Anthony Dona Marie-Laëtitia Thézénas Philip D Charles Roman Fischer Maria Kaisar Henri G D Leuvenink Rutger J Ploeg Benedikt M Kessler

Sci Rep 2018 06 4;8(1):8539. Epub 2018 Jun 4.

Target Discovery Institute, Nuffield Department of Medicine, Old Road Campus, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/s41598-018-26804-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986744PMC
June 2018

Proteomic profiling of the brain of mice with experimental cerebral malaria.

Authors:
Ehab Moussa Honglei Huang Malika Ahras Amar Lall Marie L Thezenas Roman Fischer Benedikt M Kessler Arnab Pain Oliver Billker Climent Casals-Pascual

J Proteomics 2018 05 5;180:61-69. Epub 2017 Jun 5.

Wellcome Trust Centre for Human Genetics, Oxford, UK. Electronic address:

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May 2018

FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment.

Authors:
Emilia Dimitrova Takashi Kondo Angelika Feldmann Manabu Nakayama Yoko Koseki Rebecca Konietzny Benedikt M Kessler Haruhiko Koseki Robert J Klose

Elife 2018 05 29;7. Epub 2018 May 29.

Department of Biochemistry, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.7554/eLife.37084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997449PMC
May 2018

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

Authors:
Evanna L Mills Dylan G Ryan Hiran A Prag Dina Dikovskaya Deepthi Menon Zbigniew Zaslona Mark P Jedrychowski Ana S H Costa Maureen Higgins Emily Hams John Szpyt Marah C Runtsch Martin S King Joanna F McGouran Roman Fischer Benedikt M Kessler Anne F McGettrick Mark M Hughes Richard G Carroll Lee M Booty Elena V Knatko Paul J Meakin Michael L J Ashford Louise K Modis Gino Brunori Daniel C Sévin Padraic G Fallon Stuart T Caldwell Edmund R S Kunji Edward T Chouchani Christian Frezza Albena T Dinkova-Kostova Richard C Hartley Michael P Murphy Luke A O'Neill

Nature 2018 04 28;556(7699):113-117. Epub 2018 Mar 28.

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1038/nature25986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047741PMC
April 2018

FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.

Authors:
Ella Fung Carmen Richter Hong-Bin Yang Isabell Schäffer Roman Fischer Benedikt M Kessler Florian Bassermann Vincenzo D'Angiolella

EMBO Rep 2018 03 18;19(3). Epub 2018 Jan 18.

Department of Oncology, Cancer Research UK and Medical Research Council Institute for Radiation Oncology, University of Oxford, Oxford, UK

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http://embor.embopress.org/lookup/doi/10.15252/embr.20174479
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http://dx.doi.org/10.15252/embr.201744799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836097PMC
March 2018

A robust mass spectrometry method for rapid profiling of erythrocyte ghost membrane proteomes.

Authors:
Haddy K S Fye Paul Mrosso Lesley Bruce Marie-Laëtitia Thézénas Simon Davis Roman Fischer Gration L Rwegasira Julie Makani Benedikt M Kessler

Clin Proteomics 2018 21;15:14. Epub 2018 Mar 21.

1Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford, OX3 7FZ UK.

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https://clinicalproteomicsjournal.biomedcentral.com/articles
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863380PMC
March 2018

Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis.

Authors:
Alexander G Thompson Elizabeth Gray Marie-Laëtitia Thézénas Philip D Charles Samuel Evetts Michele T Hu Kevin Talbot Roman Fischer Benedikt M Kessler Martin R Turner

Ann Neurol 2018 02 9;83(2):258-268. Epub 2018 Feb 9.

Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom.

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http://dx.doi.org/10.1002/ana.25143DOI Listing
February 2018

Mapping protein interactions of sodium channel Na1.7 using epitope-tagged gene-targeted mice.

Authors:
Alexandros H Kanellopoulos Jennifer Koenig Honglei Huang Martina Pyrski Queensta Millet Stéphane Lolignier Toru Morohashi Samuel J Gossage Maude Jay John E Linley Georgios Baskozos Benedikt M Kessler James J Cox Annette C Dolphin Frank Zufall John N Wood Jing Zhao

EMBO J 2018 02 15;37(3):427-445. Epub 2018 Jan 15.

Molecular Nociception Group, WIBR, University College London, London, UK

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http://dx.doi.org/10.15252/embj.201796692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793798PMC
February 2018

Biochemical and Mass Spectrometry-Based Approaches to Profile SUMOylation in Human Cells.

Authors:
Benedikt M Kessler Sara Bursomanno Joanna F McGouran Ian D Hickson Ying Liu

Methods Mol Biol 2017 ;1491:131-144

Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Panum Institute, Astra Zeneca, Godsmottagningen MA1, Pepparedsleden, 43183, Mölndal, Sweden.

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http://dx.doi.org/10.1007/978-1-4939-6439-0_10DOI Listing
January 2018

Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7.

Authors:
Philip A Gerken Jamie R Wolstenhulme Anthony Tumber Stephanie B Hatch Yijia Zhang Susanne Müller Shane A Chandler Barbara Mair Fengling Li Sebastian M B Nijman Rebecca Konietzny Tamas Szommer Clarence Yapp Oleg Fedorov Justin L P Benesch Masoud Vedadi Benedikt M Kessler Akane Kawamura Paul E Brennan Martin D Smith

Angew Chem Int Ed Engl 2017 12 7;56(49):15555-15559. Epub 2017 Nov 7.

Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1002/anie.201706788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725665PMC
December 2017

Association of Distinct Fine Specificities of Anti-Citrullinated Peptide Antibodies With Elevated Immune Responses to Prevotella intermedia in a Subgroup of Patients With Rheumatoid Arthritis and Periodontitis.

Authors:
Anja Schwenzer Anne-Marie Quirke Anna M Marzeda Alicia Wong Anna B Montgomery Harlan R Sayles Sigrun Eick Katarzyna Gawron Maria Chomyszyn-Gajewska Katarzyna Łazarz-Bartyzel Simon Davis Jan Potempa Benedikt M Kessler Roman Fischer Patrick J Venables Jeffrey B Payne Ted R Mikuls Kim S Midwood

Arthritis Rheumatol 2017 12 30;69(12):2303-2313. Epub 2017 Oct 30.

University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1002/art.40227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711558PMC
December 2017

Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14.

Authors:
Marion Schuller Kerstin Riedel Ian Gibbs-Seymour Kristin Uth Christian Sieg André P Gehring Ivan Ahel Franz Bracher Benedikt M Kessler Jonathan M Elkins Stefan Knapp

ACS Chem Biol 2017 11 19;12(11):2866-2874. Epub 2017 Oct 19.

Structural Genomics Consortium (SGC), Nuffield Department of Clinical Medicine, University of Oxford , Oxford, OX3 7DQ, United Kingdom.

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http://dx.doi.org/10.1021/acschembio.7b00445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089342PMC
November 2017

Mechanisms by which Porphyromonas gingivalis evades innate immunity.

Authors:
Kaveh Abdi Tsute Chen Brian A Klein Albert K Tai Jill Coursen Xiangdong Liu Jeff Skinner Saravanan Periasamy Youngnim Choi Benedikt M Kessler Robert J Palmer Apostolos Gittis Polly Matzinger Margaret J Duncan Nevil J Singh

PLoS One 2017 3;12(8):e0182164. Epub 2017 Aug 3.

University of Maryland School of Medicine, Department of Microbiology & Immunology, Baltimore, Maryland United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182164PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542538PMC
October 2017

A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN.

Authors:
Aurelia Weber Paul R Elliott Adan Pinto-Fernandez Sarah Bonham Benedikt M Kessler David Komander Farid El Oualid Daniel Krappmann

Cell Chem Biol 2017 Oct 14;24(10):1299-1313.e7. Epub 2017 Sep 14.

Research Unit Cellular Signal Integration, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658516PMC
October 2017

Molecular basis of USP7 inhibition by selective small-molecule inhibitors.

Authors:
Andrew P Turnbull Stephanos Ioannidis Wojciech W Krajewski Adan Pinto-Fernandez Claire Heride Agnes C L Martin Louise M Tonkin Elizabeth C Townsend Shane M Buker David R Lancia Justin A Caravella Angela V Toms Thomas M Charlton Johanna Lahdenranta Erik Wilker Bruce C Follows Nicola J Evans Lucy Stead Cristina Alli Vladislav V Zarayskiy Adam C Talbot Alexandre J Buckmelter Minghua Wang Crystal L McKinnon Fabienne Saab Joanna F McGouran Hannah Century Malte Gersch Marc S Pittman C Gary Marshall Tony M Raynham Mary Simcox Lorna M D Stewart Sheila B McLoughlin Jaime A Escobedo Kenneth W Bair Christopher J Dinsmore Tim R Hammonds Sunkyu Kim Sylvie Urbé Michael J Clague Benedikt M Kessler David Komander

Nature 2017 10 18;550(7677):481-486. Epub 2017 Oct 18.

Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.

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http://www.nature.com/doifinder/10.1038/nature24451
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029662PMC
October 2017

Protein arginine methylation: a prominent modification and its demethylation.

Authors:
Juste Wesche Sarah Kühn Benedikt M Kessler Maayan Salton Alexander Wolf

Cell Mol Life Sci 2017 09 31;74(18):3305-3315. Epub 2017 Mar 31.

Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München-German Research Center for Environmental Health, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1007/s00018-017-2515-zDOI Listing
September 2017

A quantitative label-free analysis of the extracellular proteome of human supraspinatus tendon reveals damage to the pericellular and elastic fibre niches in torn and aged tissue.

Authors:
Osnat Hakimi Nicola Ternette Richard Murphy Benedikt M Kessler Andrew Carr

PLoS One 2017 18;12(5):e0177656. Epub 2017 May 18.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177656PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436668PMC
September 2017

Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes.

Authors:
Julie Adam Reshma Ramracheya Margarita V Chibalina Nicola Ternette Alexander Hamilton Andrei I Tarasov Quan Zhang Eduardo Rebelato Nils J G Rorsman Rafael Martín-Del-Río Amy Lewis Gizem Özkan Hyun Woong Do Peter Spégel Kaori Saitoh Keiko Kato Kaori Igarashi Benedikt M Kessler Christopher W Pugh Jorge Tamarit-Rodriguez Hindrik Mulder Anne Clark Norma Frizzell Tomoyoshi Soga Frances M Ashcroft Andrew Silver Patrick J Pollard Patrik Rorsman

Cell Rep 2017 Sep;20(13):3135-3148

Radcliffe Department of Medicine, OCDEM, Churchill Hospital, University of Oxford, Oxford OX3 7LE, UK; Department of Physiology, Institute of Neuroscience and Physiology, University of Göteborg, 405 30 Göteborg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.08.093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637167PMC
September 2017

Phosphorylation Induces Structural Changes in the Autographa californica Nucleopolyhedrovirus P10 Protein.

Authors:
Farheen Raza Joanna F McGouran Benedikt M Kessler Robert D Possee Linda A King

J Virol 2017 07 9;91(13). Epub 2017 Jun 9.

Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, United Kingdom

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http://jvi.asm.org/lookup/doi/10.1128/JVI.00002-17
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469262PMC
July 2017

E3 Ligase cIAP2 Mediates Downregulation of MRE11 and Radiosensitization in Response to HDAC Inhibition in Bladder Cancer.

Authors:
Judith Nicholson Sarah J Jevons Blaz Groselj Sophie Ellermann Rebecca Konietzny Martin Kerr Benedikt M Kessler Anne E Kiltie

Cancer Res 2017 06 31;77(11):3027-3039. Epub 2017 Mar 31.

CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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June 2017

Linker Histone H1.2 Directs Genome-wide Chromatin Association of the Retinoblastoma Tumor Suppressor Protein and Facilitates Its Function.

Authors:
Shonagh Munro Edward S Hookway Melanie Floderer Simon M Carr Rebecca Konietzny Benedikt M Kessler Udo Oppermann Nicholas B La Thangue

Cell Rep 2017 06;19(11):2193-2201

Laboratory of Cancer Biology, Medical Sciences Division, Department of Oncology, University of Oxford, Old Road Campus Research Building, Old Road Campus, Oxford OX3 7DQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.05.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478878PMC
June 2017

A novel workflow combining plaque imaging, plaque and plasma proteomics identifies biomarkers of human coronary atherosclerotic plaque disruption.

Authors:
Regent Lee Roman Fischer Philip D Charles David Adlam Alessandro Valli Katalin Di Gleria Rajesh K Kharbanda Robin P Choudhury Charalambos Antoniades Benedikt M Kessler Keith M Channon

Clin Proteomics 2017 19;14:22. Epub 2017 Jun 19.

Division of Cardiovascular Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1186/s12014-017-9157-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477097PMC
June 2017

Development of a T-cell Receptor Mimic Antibody against Wild-Type p53 for Cancer Immunotherapy.

Authors:
Demin Li Carol Bentley Amanda Anderson Sarah Wiblin Kirstie L S Cleary Sofia Koustoulidou Tasneem Hassanali Jenna Yates Jenny Greig Marloes Olde Nordkamp Iva Trenevska Nicola Ternette Benedikt M Kessler Bart Cornelissen Mark S Cragg Alison H Banham

Cancer Res 2017 05 31;77(10):2699-2711. Epub 2017 Mar 31.

Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-16-3247DOI Listing
May 2017

Optimizing 2D gas chromatography mass spectrometry for robust tissue, serum and urine metabolite profiling.

Authors:
Zhanru Yu Honglei Huang Alexander Reim Philip D Charles Alan Northage Dianne Jackson Ian Parry Benedikt M Kessler

Talanta 2017 Apr 7;165:685-691. Epub 2017 Jan 7.

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.talanta.2017.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294743PMC
April 2017

Correction: PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes.

Authors:
Mitsuhiro Endoh Takaho A Endo Jun Shinga Katsuhiko Hayashi Anca Farcas Kit-Wan Ma Shinsuke Ito Jafar Sharif Tamie Endoh Naoko Onaga Manabu Nakayama Tomoyuki Ishikura Osamu Masui Benedikt M Kessler Toshio Suda Osamu Ohara Akihiko Okuda Robert J Klose Haruhiko Koseki

Elife 2017 04 25;6. Epub 2017 Apr 25.

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http://dx.doi.org/10.7554/eLife.27970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404914PMC
April 2017

A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance.

Authors:
Jade Bailey Andrew Shaw Roman Fischer Brent J Ryan Benedikt M Kessler James McCullagh Richard Wade-Martins Keith M Channon Mark J Crabtree

Free Radic Biol Med 2017 03 17;104:214-225. Epub 2017 Jan 17.

BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom.

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338462PMC
March 2017

Expanding Proteome Coverage with CHarge Ordered Parallel Ion aNalysis (CHOPIN) Combined with Broad Specificity Proteolysis.

Authors:
Simon Davis Philip D Charles Lin He Peter Mowlds Benedikt M Kessler Roman Fischer

J Proteome Res 2017 03 22;16(3):1288-1299. Epub 2017 Feb 22.

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford , Roosevelt Drive, Oxford OX3 7FZ, United Kingdom.

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http://dx.doi.org/10.1021/acs.jproteome.6b00915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363888PMC
March 2017

PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes.

Authors:
Mitsuhiro Endoh Takaho A Endo Jun Shinga Katsuhiko Hayashi Anca Farcas Kit-Wan Ma Shinsuke Ito Jafar Sharif Tamie Endoh Naoko Onaga Manabu Nakayama Tomoyuki Ishikura Osamu Masui Benedikt M Kessler Toshio Suda Osamu Ohara Akihiko Okuda Robert Klose Haruhiko Koseki

Elife 2017 03 17;6. Epub 2017 Mar 17.

Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

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http://dx.doi.org/10.7554/eLife.21064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5375644PMC
March 2017

The why and how of amino acid analytics in cancer diagnostics and therapy.

Authors:
Friederike Manig Konstantin Kuhne Cläre von Neubeck Uwe Schwarzenbolz Zhanru Yu Benedikt M Kessler Jens Pietzsch Leoni A Kunz-Schughart

J Biotechnol 2017 Jan 5;242:30-54. Epub 2016 Dec 5.

OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden and Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany; CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jbiotec.2016.12.001DOI Listing
January 2017

CBP/p300 Bromodomains Regulate Amyloid-like Protein Aggregation upon Aberrant Lysine Acetylation.

Authors:
Heidi Olzscha Oleg Fedorov Benedikt M Kessler Stefan Knapp Nicholas B La Thangue

Cell Chem Biol 2017 Jan 15;24(1):9-23. Epub 2016 Dec 15.

Department of Oncology, University of Oxford, Old Road Campus Research Building, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2016.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266481PMC
January 2017

Magnitude and Quality of Cytokine and Chemokine Storm during Acute Infection Distinguish Nonprogressive and Progressive Simian Immunodeficiency Virus Infections of Nonhuman Primates.

Authors:
Sheila M Keating John W Heitman Shiquan Wu Xutao Deng Andrea R Stacey Roland C Zahn Maurus de la Rosa Samantha L Finstad Jeffrey D Lifson Michael Piatak Marie-Claire Gauduin Benedikt M Kessler Nicola Ternette Angela Carville R Paul Johnson Ronald C Desrosiers Norman L Letvin Persephone Borrow Philip J Norris Joern E Schmitz

J Virol 2016 Nov 28;90(22):10339-10350. Epub 2016 Oct 28.

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard University, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1128/JVI.01061-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105668PMC
November 2016

Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity.

Authors:
Tom H Wright Ben J Bower Justin M Chalker Gonçalo J L Bernardes Rafal Wiewiora Wai-Lung Ng Ritu Raj Sarah Faulkner M Robert J Vallée Anuchit Phanumartwiwath Oliver D Coleman Marie-Laëtitia Thézénas Maola Khan Sébastien R G Galan Lukas Lercher Matthew W Schombs Stefanie Gerstberger Maria E Palm-Espling Andrew J Baldwin Benedikt M Kessler Timothy D W Claridge Shabaz Mohammed Benjamin G Davis

Science 2016 11 22;354(6312). Epub 2016 Sep 22.

Department of Chemistry, University of Oxford, Oxford OX1 3TA, UK.

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http://www.sciencemag.org/cgi/doi/10.1126/science.aag1465
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November 2016

Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP.

Authors:
Min Lu Hilde Breyssens Victoria Salter Shan Zhong Ying Hu Caroline Baer Indrika Ratnayaka Alex Sullivan Nicholas R Brown Jane Endicott Stefan Knapp Benedikt M Kessler Mark R Middleton Christian Siebold E Yvonne Jones Elena V Sviderskaya Jonathan Cebon Thomas John Otavia L Caballero Colin R Goding Xin Lu

Cancer Cell 2016 11;30(5):822-823

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http://dx.doi.org/10.1016/j.ccell.2016.09.019DOI Listing
November 2016

Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair.

Authors:
Bruno Vaz Marta Popovic Joseph A Newman John Fielden Hazel Aitkenhead Swagata Halder Abhay Narayan Singh Iolanda Vendrell Roman Fischer Ignacio Torrecilla Neele Drobnitzky Raimundo Freire David J Amor Paul J Lockhart Benedikt M Kessler Gillies W McKenna Opher Gileadi Kristijan Ramadan

Mol Cell 2016 11 27;64(4):704-719. Epub 2016 Oct 27.

Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.09.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128727PMC
November 2016

Identification of an immunodominant peptide from citrullinated tenascin-C as a major target for autoantibodies in rheumatoid arthritis.

Authors:
Anja Schwenzer Xia Jiang Ted R Mikuls Jeffrey B Payne Harlan R Sayles Anne-Marie Quirke Benedikt M Kessler Roman Fischer Patrick J Venables Karin Lundberg Kim S Midwood

Ann Rheum Dis 2016 10 9;75(10):1876-83. Epub 2015 Dec 9.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/annrheumdis-2015-208495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036245PMC
October 2016

Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du Renne.

Authors:
Frido Welker Mateja Hajdinjak Sahra Talamo Klervia Jaouen Michael Dannemann Francine David Michèle Julien Matthias Meyer Janet Kelso Ian Barnes Selina Brace Pepijn Kamminga Roman Fischer Benedikt M Kessler John R Stewart Svante Pääbo Matthew J Collins Jean-Jacques Hublin

Proc Natl Acad Sci U S A 2016 10 16;113(40):11162-11167. Epub 2016 Sep 16.

Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.

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http://dx.doi.org/10.1073/pnas.1605834113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056053PMC
October 2016

RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes.

Authors:
Nathan R Rose Hamish W King Neil P Blackledge Nadezda A Fursova Katherine Ji Ember Roman Fischer Benedikt M Kessler Robert J Klose

Elife 2016 10 5;5. Epub 2016 Oct 5.

Department of Biochemistry, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.7554/eLife.18591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065315PMC
October 2016

Plasma Biomarker Profile Alterations during Variable Blood Storage.

Authors:
Maria Kaisar Leon F A van Dullemen Marie-Laëtitia Thézénas Philip D Charles Rutger J Ploeg Benedikt M Kessler

Clin Chem 2016 09 20;62(9):1272-4. Epub 2016 Jul 20.

Target Discovery Institute Nuffield Department of Medicine University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1373/clinchem.2016.257246DOI Listing
September 2016

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.

Authors:
Paul R Elliott Derek Leske Matous Hrdinka Katrin Bagola Berthe K Fiil Stephen H McLaughlin Jane Wagstaff Norbert Volkmar John C Christianson Benedikt M Kessler Stefan M V Freund David Komander Mads Gyrd-Hansen

Mol Cell 2016 09 30;63(6):990-1005. Epub 2016 Aug 30.

Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031558PMC
September 2016

Protein sequences bound to mineral surfaces persist into deep time.

Authors:
Beatrice Demarchi Shaun Hall Teresa Roncal-Herrero Colin L Freeman Jos Woolley Molly K Crisp Julie Wilson Anna Fotakis Roman Fischer Benedikt M Kessler Rosa Rakownikow Jersie-Christensen Jesper V Olsen James Haile Jessica Thomas Curtis W Marean John Parkington Samantha Presslee Julia Lee-Thorp Peter Ditchfield Jacqueline F Hamilton Martyn W Ward Chunting Michelle Wang Marvin D Shaw Terry Harrison Manuel Domínguez-Rodrigo Ross DE MacPhee Amandus Kwekason Michaela Ecker Liora Kolska Horwitz Michael Chazan Roland Kröger Jane Thomas-Oates John H Harding Enrico Cappellini Kirsty Penkman Matthew J Collins

Elife 2016 Sep 27;5. Epub 2016 Sep 27.

BioArCh, Department of Archaeology, University of York, York, United Kingdom.

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http://dx.doi.org/10.7554/eLife.17092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039028PMC
September 2016

Plasma degradome affected by variable storage of human blood.

Authors:
Maria Kaisar Leon F A van Dullemen Marie-Laëtitia Thézénas M Zeeshan Akhtar Honglei Huang Sandrine Rendel Philip D Charles Roman Fischer Rutger J Ploeg Benedikt M Kessler

Clin Proteomics 2016 26;13:26. Epub 2016 Sep 26.

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ UK.

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http://dx.doi.org/10.1186/s12014-016-9126-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037888PMC
September 2016

Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs.

Authors:
Anne Grijzenhout Jonathan Godwin Haruhiko Koseki Michal Ryszard Gdula Dorota Szumska Joanna F McGouran Shoumo Bhattacharya Benedikt M Kessler Neil Brockdorff Sarah Cooper

Development 2016 08 17;143(15):2716-23. Epub 2016 Jun 17.

Developmental Epigenetics, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK

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http://dev.biologists.org/lookup/doi/10.1242/dev.123935
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http://dx.doi.org/10.1242/dev.123935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004903PMC
August 2016

Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease.

Authors:
Zoi Alexopoulou Johannes Lang Rebecca M Perrett Myriam Elschami Madeleine E D Hurry Hyoung Tae Kim Dimitra Mazaraki Aron Szabo Benedikt M Kessler Alfred Lewis Goldberg Olaf Ansorge Tudor A Fulga George K Tofaris

Proc Natl Acad Sci U S A 2016 08 21;113(32):E4688-97. Epub 2016 Jul 21.

Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1523597113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987833PMC
August 2016

Salt-Inducible Kinase 2 Couples Ovarian Cancer Cell Metabolism with Survival at the Adipocyte-Rich Metastatic Niche.

Authors:
Fabrizio Miranda David Mannion Shujuan Liu Yiyan Zheng Lingegowda S Mangala Clara Redondo Sandra Herrero-Gonzalez Ruoyan Xu Charlotte Taylor Donatien Fotso Chedom Mohammad Karaminejadranjbar Ashwag Albukhari Dahai Jiang Sunila Pradeep Cristian Rodriguez-Aguayo Gabriel Lopez-Berestein Eidarus Salah Kamal R Abdul Azeez Jonathan M Elkins Leticia Campo Kevin A Myers Daniel Klotz Serena Bivona Sunanda Dhar Robert C Bast Hideyuki Saya Hwan Geun Choi Nathanael S Gray Roman Fischer Benedikt M Kessler Christopher Yau Anil K Sood Takeshi Motohara Stefan Knapp Ahmed Ashour Ahmed

Cancer Cell 2016 08 28;30(2):273-289. Epub 2016 Jul 28.

Ovarian Cancer Cell Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford OX3 9DS, UK; Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Women's Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.06.020DOI Listing
August 2016

DUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic Targets.

Authors:
Adan Pinto-Fernandez Benedikt M Kessler

Front Genet 2016 28;7:133. Epub 2016 Jul 28.

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford Oxford, UK.

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http://dx.doi.org/10.3389/fgene.2016.00133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963401PMC
August 2016

SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.

Authors:
Madalina Raducu Ella Fung Sébastien Serres Paola Infante Alessandro Barberis Roman Fischer Claire Bristow Marie-Laëtitia Thézénas Csaba Finta John C Christianson Francesca M Buffa Benedikt M Kessler Nicola R Sibson Lucia Di Marcotullio Rune Toftgård Vincenzo D'Angiolella

EMBO J 2016 07 27;35(13):1400-16. Epub 2016 May 27.

Cancer Research UK and Medical Research Council Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK

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http://dx.doi.org/10.15252/embj.201593374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884786PMC
July 2016

Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib.

Authors:
Sebastian Mathea Kamal R Abdul Azeez Eidarus Salah Cynthia Tallant Finn Wolfreys Rebecca Konietzny Roman Fischer Hua Jane Lou Paul E Brennan Gisela Schnapp Alexander Pautsch Benedikt M Kessler Benjamin E Turk Stefan Knapp

ACS Chem Biol 2016 06 31;11(6):1595-602. Epub 2016 Mar 31.

Target Discovery Institute (TDI), Nuffield Department of Medicine, University of Oxford , Oxford, OX37FZ, United Kingdom.

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http://dx.doi.org/10.1021/acschembio.6b00043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518171PMC
June 2016

Integrative Phosphoproteomics Links IL-23R Signaling with Metabolic Adaptation in Lymphocytes.

Authors:
Corinne Lochmatter Roman Fischer Philip D Charles Zhanru Yu Fiona Powrie Benedikt M Kessler

Sci Rep 2016 Apr 15;6:24491. Epub 2016 Apr 15.

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK.

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http://dx.doi.org/10.1038/srep24491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832251PMC
April 2016

DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair.

Authors:
Songmin Ying Zhihui Chen Annette L Medhurst Jessica A Neal Zhengqiang Bao Oliver Mortusewicz Joanna McGouran Xinming Song Huahao Shen Freddie C Hamdy Benedikt M Kessler Katheryn Meek Thomas Helleday

Cancer Res 2016 Mar 24;76(5):1078-88. Epub 2015 Nov 24.

Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://cancerres.aacrjournals.org/content/early/2015/11/24/0
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http://cancerres.aacrjournals.org/content/early/2015/11/24/0
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-15-0608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867494PMC
March 2016

Defining the HLA class I-associated viral antigen repertoire from HIV-1-infected human cells.

Authors:
Nicola Ternette Hongbing Yang Thomas Partridge Anuska Llano Samandhy Cedeño Roman Fischer Philip D Charles Nadine L Dudek Beatriz Mothe Manuel Crespo William M Fischer Bette T M Korber Morten Nielsen Persephone Borrow Anthony W Purcell Christian Brander Lucy Dorrell Benedikt M Kessler Tomáš Hanke

Eur J Immunol 2016 Jan 4;46(1):60-9. Epub 2015 Nov 4.

The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1002/eji.201545890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737398PMC
January 2016

USP4 Auto-Deubiquitylation Promotes Homologous Recombination.

Authors:
Paul Wijnhoven Rebecca Konietzny Andrew N Blackford Jonathan Travers Benedikt M Kessler Ryotaro Nishi Stephen P Jackson

Mol Cell 2015 Nov 8;60(3):362-73. Epub 2015 Oct 8.

The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK; The Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643306PMC
November 2015

Expanding the yeast protein arginine methylome.

Authors:
Michael Plank Roman Fischer Vincent Geoghegan Philip D Charles Rebecca Konietzny Oreste Acuto Catherine Pears Christopher J Schofield Benedikt M Kessler

Proteomics 2015 Sep 2;15(18):3232-43. Epub 2015 Jul 2.

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1002/pmic.201500032DOI Listing
September 2015

Correction. The presence of prolines in the flanking region of an immunodominant HIV-2 gag epitope influences the quality and quantity of the epitope generated.

Authors:
Sabelle Jallow Aleksandra Leligdowicz Holger B Kramer Clayton Onyango Matthew Cotten Cynthia Wright Hilton C Whittle Andrew McMichael Tao Dong Benedikt M Kessler Sarah L Rowland-Jones

Eur J Immunol 2015 Sep;45(9):2701

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http://dx.doi.org/10.1002/eji.201570096DOI Listing
September 2015

The presence of prolines in the flanking region of an immunodominant HIV-2 gag epitope influences the quality and quantity of the epitope generated.

Authors:
Sabelle Jallow Aleksandra Leligdowicz Holger B Kramer Clayton Onyango Matthew Cotten Cynthia Wright Hilton C Whittle Andrew McMichael Tao Dong Benedikt M Kessler Sarah L Rowland-Jones

Eur J Immunol 2015 Aug 24;45(8):2232-42. Epub 2015 Jun 24.

Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1002/eji.201545451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832300PMC
August 2015

CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer.

Authors:
Melania Zauri Georgina Berridge Marie-Laëtitia Thézénas Kathryn M Pugh Robert Goldin Benedikt M Kessler Skirmantas Kriaucionis

Nature 2015 Aug 22;524(7563):114-8. Epub 2015 Jul 22.

Ludwig Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK.

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http://search.proquest.com/openview/0769e1725259cda7a96ee534
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http://www.nature.com/doifinder/10.1038/nature14948
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866471PMC
August 2015

The mutant Moonwalker TRPC3 channel links calcium signaling to lipid metabolism in the developing cerebellum.

Authors:
Anna Dulneva Sheena Lee Peter L Oliver Katalin Di Gleria Benedikt M Kessler Kay E Davies Esther B E Becker

Hum Mol Genet 2015 Jul 23;24(14):4114-25. Epub 2015 Apr 23.

Medical Research Council Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK and

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddv150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476454PMC
July 2015

Hypoxia metabolism in ageing.

Authors:
Alessandro Valli Adrian L Harris Benedikt M Kessler

Aging (Albany NY) 2015 Jul;7(7):465-6

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543034PMC
http://dx.doi.org/10.18632/aging.100782DOI Listing
July 2015

Early Kinetics of the HLA Class I-Associated Peptidome of MVA.HIVconsv-Infected Cells.

Authors:
Nicola Ternette Peter D Block Álvaro Sánchez-Bernabéu Nicola Borthwick Elisa Pappalardo Sultan Abdul-Jawad Beatrice Ondondo Philip D Charles Lucy Dorrell Benedikt M Kessler Tomáš Hanke

J Virol 2015 Jun 25;89(11):5760-71. Epub 2015 Mar 25.

The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1128/JVI.03627-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442425PMC
June 2015

Regulation of SUMO2 target proteins by the proteasome in human cells exposed to replication stress.

Authors:
Sara Bursomanno Joanna F McGouran Benedikt M Kessler Ian D Hickson Ying Liu

J Proteome Res 2015 Apr 19;14(4):1687-99. Epub 2015 Mar 19.

†Center for Chromosome Stability, and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Panum Institute, Blegdamsvej 3b, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/pr500997pDOI Listing
April 2015

Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability.

Authors:
Enni Markkanen Roman Fischer Marina Ledentcova Benedikt M Kessler Grigory L Dianov

Nucleic Acids Res 2015 Apr 23;43(7):3667-79. Epub 2015 Mar 23.

Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Roosevelt Drive, Oxford OX3 7DQ, United Kingdom Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Lavrenteva 10, 630090 Novosibirsk, Russia

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http://dx.doi.org/10.1093/nar/gkv222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402536PMC
April 2015

Identification of distinct circulating exosomes in Parkinson's disease.

Authors:
Paul R Tomlinson Ying Zheng Roman Fischer Ronny Heidasch Chris Gardiner Samuel Evetts Michele Hu Richard Wade-Martins Martin R Turner John Morris Kevin Talbot Benedikt M Kessler George K Tofaris

Ann Clin Transl Neurol 2015 Apr 6;2(4):353-61. Epub 2015 Feb 6.

Nuffield Department of Clinical Neurosciences, University of Oxford Oxford, United Kingdom ; Oxford Parkinson's Disease Centre, University of Oxford Oxford, United Kingdom.

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http://dx.doi.org/10.1002/acn3.175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402081PMC
April 2015

Erratum: OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo.

Authors:
Diego Iglesias-Gato Yin-Choy Chuan Ning Jiang Charlotte Svensson Jing Bao Zhiqun Shang Indranil Paul Lars Egevad Benedikt M Kessler Pernilla Wikström Yuanjie Niu Amilcar Flores-Morales

Mol Cancer 2015 Apr 18;14:88. Epub 2015 Apr 18.

The Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, 2200, Copenhagen, Denmark.

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http://molecular-cancer.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12943-015-0341-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404127PMC
April 2015