Publications by authors named "Benedikt Kessler"

100Publications

Ubiquitomics: An Overview and Future.

Biomolecules 2020 Oct 17;10(10). Epub 2020 Oct 17.

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/biom10101453DOI Listing
October 2020

Urine recirculation prolongs normothermic kidney perfusion via more optimal metabolic homeostasis - a proteomics study.

Am J Transplant 2020 Oct 5. Epub 2020 Oct 5.

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajt.16334DOI Listing
October 2020

Distinct contributions of DNA methylation and histone acetylation to the genomic occupancy of transcription factors.

Genome Res 2020 Oct 22;30(10):1393-1406. Epub 2020 Sep 22.

Ludwig Institute for Cancer Research, University of Oxford, Oxford, OX3 7DQ, United Kingdom;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gr.257576.119DOI Listing
October 2020

CSF extracellular vesicle proteomics demonstrates altered protein homeostasis in amyotrophic lateral sclerosis.

Clin Proteomics 2020 17;17:31. Epub 2020 Aug 17.

Nuffield Department of Clinical Neurosciences, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Oxford, OX3 9DU UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12014-020-09294-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433176PMC
August 2020

An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress.

Neurobiol Dis 2020 Oct 13;144:105050. Epub 2020 Aug 13.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, United Kingdom; Lead Contact. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2020.105050DOI Listing
October 2020

Editorial: Probing the Ubiquitin Landscape.

Front Chem 2020 20;8:449. Epub 2020 May 20.

Department of Cell and Chemical Biology, Oncode Institute, Leiden University Medical Centre, Leiden, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fchem.2020.00449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251165PMC
May 2020

Characterization of exosomes in peritoneal fluid of endometriosis patients.

Fertil Steril 2020 02;113(2):364-373.e2

Endometriosis CaRe Centre, Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fertnstert.2019.09.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057257PMC
February 2020

BMP signaling inhibition in secondary cells remodels the seminal proteome and self and rival ejaculate functions.

Proc Natl Acad Sci U S A 2019 12 18;116(49):24719-24728. Epub 2019 Nov 18.

Edward Grey Institute, Department of Zoology, University of Oxford, OX1 3PS Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1914491116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900634PMC
December 2019

Proteomics analysis of the matrisome from MC38 experimental mouse liver metastases.

Am J Physiol Gastrointest Liver Physiol 2019 11 23;317(5):G625-G639. Epub 2019 Sep 23.

Cancer Research United Kingdom/Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpgi.00014.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879896PMC
November 2019

Regulation of the endosomal SNX27-retromer by OTULIN.

Nat Commun 2019 09 20;10(1):4320. Epub 2019 Sep 20.

Research Unit Cellular Signal Integration, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München, Ingolstaedter Landstrasse 1, 85764, Neuherberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-019-12309-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754446PMC
September 2019

A Novel Role for Triglyceride Metabolism in Foxp3 Expression.

Front Immunol 2019 13;10:1860. Epub 2019 Aug 13.

Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2019.01860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701200PMC
September 2020

Ataxin-3 Links NOD2 and TLR2 Mediated Innate Immune Sensing and Metabolism in Myeloid Cells.

Front Immunol 2019 19;10:1495. Epub 2019 Jul 19.

MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2019.01495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659470PMC
October 2020

Capturing the dynamics of genome replication on individual ultra-long nanopore sequence reads.

Nat Methods 2019 05 22;16(5):429-436. Epub 2019 Apr 22.

Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41592-019-0394-yDOI Listing
May 2019

Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and Proliferation.

Mol Cell Proteomics 2019 07 22;18(7):1330-1344. Epub 2019 Apr 22.

From the ‡Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University, Jerusalem, Israel, 9112001;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/mcp.RA119.001392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601214PMC
July 2019

Improved profiling of polyamines using two-dimensional gas chromatography mass spectrometry.

Talanta 2019 Jul 18;199:184-188. Epub 2019 Feb 18.

TDI Mass Spectrometry Laboratory, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00399140193020
Publisher Site
http://dx.doi.org/10.1016/j.talanta.2019.02.062DOI Listing
July 2019

From herbal small RNAs to one medicine.

Sci China Life Sci 2019 03 1;62(3):285-287. Epub 2019 Mar 1.

State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS-Oxford Institute, Chinese Academy of Medical Sciences, Department of Biochemistry, Peking Union Medical College, Beijing, 100005, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11427-019-9513-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089335PMC
March 2019

Deacetylation Inhibition Reverses PABPN1-Dependent Muscle Wasting.

iScience 2019 Feb 22;12:318-332. Epub 2019 Jan 22.

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.isci.2019.01.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370712PMC
February 2019

The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage.

Sci Rep 2018 12 17;8(1):17891. Epub 2018 Dec 17.

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-36235-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297141PMC
December 2018

UFLC-Derived CSF Extracellular Vesicle Origin and Proteome.

Proteomics 2018 12 10;18(24):e1800257. Epub 2018 Dec 10.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/pmic.201800257
Publisher Site
http://dx.doi.org/10.1002/pmic.201800257DOI Listing
December 2018

β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression.

Cell Rep 2018 09;24(13):3404-3412

Cancer Research UK and Medical Research Council Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2018.08.076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172692PMC
September 2018

Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation.

Sci Rep 2018 09 25;8(1):14310. Epub 2018 Sep 25.

BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41598-018-32481-4
Publisher Site
http://dx.doi.org/10.1038/s41598-018-32481-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156325PMC
September 2018

A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes.

Nat Commun 2018 09 18;9(1):3798. Epub 2018 Sep 18.

Developmental Epigenetics, Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-018-06235-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143588PMC
September 2018

Glutamate receptor δ2 serum antibodies in pediatric opsoclonus myoclonus ataxia syndrome.

Neurology 2018 08 25;91(8):e714-e723. Epub 2018 Jul 25.

From the Oxford Autoimmune Neurology Group (G.B., D.A.M., T.M., P.J.W., I.W., S.T., M.P., A.V., S.R.I., B.L.), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford; Target Discovery Institute (G.B., R.F., B.K.), NDM Research Building, University of Oxford, Old Road Campus, Oxford; Paediatric Neurosciences Research Group (S.Z.), School of Medicine, University of Glasgow; Division of Structural Biology (A.R.A.), Nuffield Department of Clinical Medicine, University of Oxford, UK; Clinical Neuroimmunology (R.C.D.), Institute for Neuroscience and Muscle Research, University of Sydney, Australia; Children's Neuroscience Centre (M.L.), Evelina London Children's Hospital at St Thomas' NHS Foundation Trust, King's Health Partners Academic Health Science Centre, London; and Faculty of Medicine and Life Sciences (M.L.), King's College London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000006035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107266PMC
August 2018

Development and validation of response markers to predict survival and pleurodesis success in patients with malignant pleural effusion (PROMISE): a multicohort analysis.

Lancet Oncol 2018 07 13;19(7):930-939. Epub 2018 Jun 13.

Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Laboratory of Pleural and Lung Cancer Translational Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Oxford Respiratory Trials Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK; National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1470-2045(18)30294-8DOI Listing
July 2018

FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.

EMBO Rep 2018 03 18;19(3). Epub 2018 Jan 18.

Department of Oncology, Cancer Research UK and Medical Research Council Institute for Radiation Oncology, University of Oxford, Oxford, UK

View Article

Download full-text PDF

Source
http://embor.embopress.org/lookup/doi/10.15252/embr.20174479
Publisher Site
http://dx.doi.org/10.15252/embr.201744799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836097PMC
March 2018

Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis.

Ann Neurol 2018 02 9;83(2):258-268. Epub 2018 Feb 9.

Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25143DOI Listing
February 2018

Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14.

ACS Chem Biol 2017 11 19;12(11):2866-2874. Epub 2017 Oct 19.

Structural Genomics Consortium (SGC), Nuffield Department of Clinical Medicine, University of Oxford , Oxford, OX3 7DQ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschembio.7b00445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089342PMC
November 2017

A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN.

Cell Chem Biol 2017 Oct 14;24(10):1299-1313.e7. Epub 2017 Sep 14.

Research Unit Cellular Signal Integration, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chembiol.2017.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658516PMC
October 2017

Linker Histone H1.2 Directs Genome-wide Chromatin Association of the Retinoblastoma Tumor Suppressor Protein and Facilitates Its Function.

Cell Rep 2017 06;19(11):2193-2201

Laboratory of Cancer Biology, Medical Sciences Division, Department of Oncology, University of Oxford, Old Road Campus Research Building, Old Road Campus, Oxford OX3 7DQ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2017.05.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478878PMC
June 2017

Phosphorylation Induces Structural Changes in the Autographa californica Nucleopolyhedrovirus P10 Protein.

J Virol 2017 07 9;91(13). Epub 2017 Jun 9.

Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, United Kingdom

View Article

Download full-text PDF

Source
http://jvi.asm.org/lookup/doi/10.1128/JVI.00002-17
Publisher Site
http://dx.doi.org/10.1128/JVI.00002-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469262PMC
July 2017

Protein arginine methylation: a prominent modification and its demethylation.

Cell Mol Life Sci 2017 09 31;74(18):3305-3315. Epub 2017 Mar 31.

Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München-German Research Center for Environmental Health, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00018-017-2515-zDOI Listing
September 2017

E3 Ligase cIAP2 Mediates Downregulation of MRE11 and Radiosensitization in Response to HDAC Inhibition in Bladder Cancer.

Cancer Res 2017 06 31;77(11):3027-3039. Epub 2017 Mar 31.

CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-16-3232DOI Listing
June 2017

Development of a T-cell Receptor Mimic Antibody against Wild-Type p53 for Cancer Immunotherapy.

Cancer Res 2017 05 31;77(10):2699-2711. Epub 2017 Mar 31.

Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-16-3247DOI Listing
May 2017

miR-193a-3p interaction with HMGB1 downregulates human endothelial cell proliferation and migration.

Sci Rep 2017 03 9;7:44137. Epub 2017 Mar 9.

Stem Cell Research, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9BQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep44137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343468PMC
March 2017

Expanding Proteome Coverage with CHarge Ordered Parallel Ion aNalysis (CHOPIN) Combined with Broad Specificity Proteolysis.

J Proteome Res 2017 03 22;16(3):1288-1299. Epub 2017 Feb 22.

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford , Roosevelt Drive, Oxford OX3 7FZ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jproteome.6b00915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363888PMC
March 2017

Optimizing 2D gas chromatography mass spectrometry for robust tissue, serum and urine metabolite profiling.

Talanta 2017 Apr 7;165:685-691. Epub 2017 Jan 7.

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.talanta.2017.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294743PMC
April 2017

A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance.

Free Radic Biol Med 2017 03 17;104:214-225. Epub 2017 Jan 17.

BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2017.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338462PMC
March 2017

CBP/p300 Bromodomains Regulate Amyloid-like Protein Aggregation upon Aberrant Lysine Acetylation.

Cell Chem Biol 2017 Jan 15;24(1):9-23. Epub 2016 Dec 15.

Department of Oncology, University of Oxford, Old Road Campus Research Building, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chembiol.2016.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266481PMC
January 2017

The why and how of amino acid analytics in cancer diagnostics and therapy.

J Biotechnol 2017 Jan 5;242:30-54. Epub 2016 Dec 5.

OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden and Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany; CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbiotec.2016.12.001DOI Listing
January 2017

Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair.

Mol Cell 2016 11 27;64(4):704-719. Epub 2016 Oct 27.

Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2016.09.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128727PMC
November 2016

Biochemical and Mass Spectrometry-Based Approaches to Profile SUMOylation in Human Cells.

Methods Mol Biol 2017 ;1491:131-144

Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Panum Institute, Astra Zeneca, Godsmottagningen MA1, Pepparedsleden, 43183, Mölndal, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-6439-0_10DOI Listing
January 2018