Publications by authors named "Benedikt Brors"

100Publications

Genome-Wide DNA Methylation Profiling in Early Stage I Lung Adenocarcinoma Reveals Predictive Aberrant Methylation in the Promoter Region of the Long Noncoding RNA PLUT: An Exploratory Study.

J Thorac Oncol 2020 08 7;15(8):1338-1350. Epub 2020 Apr 7.

Translational Lung Research Centre Heidelberg, Member of the German Centre for Lung Research (Deutsches Zentrum für Lungenforschung), Heidelberg, Germany; Translational Research Unit, Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.jtho.2020.03.023DOI Listing
August 2020

Assessment of modelling strategies for drug response prediction in cell lines and xenografts.

Sci Rep 2020 02 18;10(1):2849. Epub 2020 Feb 18.

Division of Applied Bioinformatics, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41598-020-59656-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028927PMC
February 2020

Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF.

Immunity 2020 02 7;52(2):295-312.e11. Epub 2020 Jan 7.

Regensburg Center for Interventional Immunology (RCI), Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany; Chair for Immunology, Regensburg University, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany; Immune Tolerance Group, Tumor Immunology Program, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026712PMC
February 2020

Community-driven development of a modified progression-free survival ratio for precision oncology.

ESMO Open 2019 13;4(6):e000583. Epub 2019 Nov 13.

Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1136/esmoopen-2019-000583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863673PMC
June 2020

Distributed Ledger Technology in genomics: a call for Europe.

Eur J Hum Genet 2020 02 16;28(2):139-140. Epub 2019 Sep 16.

Department of Economics and Management, Karlsruhe Institute of Technology, Kaiserstr. 89, 76133, Karlsruhe, Germany.

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http://dx.doi.org/10.1038/s41431-019-0512-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974592PMC
February 2020

Homology Modelling and Molecular Docking Studies of Selected Substituted Benzo[]imidazol-1-yl)methyl)benzimidamide Scaffolds on Adenylosuccinate Lyase Receptor.

Bioinform Biol Insights 2019 31;13:1177932219865533. Epub 2019 Jul 31.

Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.

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http://dx.doi.org/10.1177/1177932219865533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669854PMC
July 2019

Impact of post-surgical freezing delay on brain tumor metabolomics.

Metabolomics 2019 05 13;15(5):78. Epub 2019 May 13.

Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s11306-019-1541-2DOI Listing
May 2019

Generation of Whole Genome Bisulfite Sequencing Libraries from Very Low DNA Input.

Methods Mol Biol 2019 ;1956:229-248

Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/978-1-4939-9151-8_10DOI Listing
July 2019

Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories.

Cancer Cell 2018 12;34(6):996-1011.e8

Finsen Laboratory, Rigshospitalet, DK-2200, Copenhagen, Denmark; Biotech Research & Innovation Centre (BRIC), University of Copenhagen, DK-2200, Copenhagen, Denmark; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69120 Heidelberg, Germany; Charité Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444093PMC
December 2018

IGF1R upregulation confers resistance to isoform-specific inhibitors of PI3K in PIK3CA-driven ovarian cancer.

Cell Death Dis 2018 09 20;9(10):944. Epub 2018 Sep 20.

The Shraga Segal Dept. of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel.

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http://dx.doi.org/10.1038/s41419-018-1025-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148236PMC
September 2018

Distinct human circulating NKp30FcεRIγCD8 T cell population exhibiting high natural killer-like antitumor potential.

Proc Natl Acad Sci U S A 2018 06 12;115(26):E5980-E5989. Epub 2018 Jun 12.

Group of Innate Immunity, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1073/pnas.1720564115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042091PMC
June 2018

Author Correction: The landscape of genomic alterations across childhood cancers.

Nature 2018 07;559(7714):E10

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41586-018-0167-2DOI Listing
July 2018

MetaboDiff: an R package for differential metabolomic analysis.

Bioinformatics 2018 10;34(19):3417-3418

Division of Experimental Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1093/bioinformatics/bty344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157071PMC
October 2018

The landscape of genomic alterations across childhood cancers.

Nature 2018 03 28;555(7696):321-327. Epub 2018 Feb 28.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature25480DOI Listing
March 2018

Molecular Classification Substitutes for the Prognostic Variables Stage, Age, and MYCN Status in Neuroblastoma Risk Assessment.

Neoplasia 2017 Dec 5;19(12):982-990. Epub 2017 Nov 5.

Department of Experimental Pediatric Oncology, Children's Hospital, University of Cologne, Kerpener Strasse 62, 50937 Cologne, Germany; Department of Pediatric Oncology and Hematology, Children's Hospital, University of Cologne, Kerpener Strasse 62, 50937 Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne, Robert-Koch-Strasse 21, 50931 Cologne, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14765586173026
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http://dx.doi.org/10.1016/j.neo.2017.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678736PMC
December 2017

Revisiting the Road Map of Medullary Thymic Epithelial Cell Differentiation.

J Immunol 2017 11 9;199(10):3488-3503. Epub 2017 Oct 9.

Division of Developmental Immunology, German Cancer Research Center, Heidelberg 69120, Germany;

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http://dx.doi.org/10.4049/jimmunol.1700203DOI Listing
November 2017

The whole-genome landscape of medulloblastoma subtypes.

Nature 2017 07;547(7663):311-317

Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature22973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905700PMC
July 2017

Genetic and epigenetic profiling of a solitary Peutz-Jeghers colon polyp.

Cold Spring Harb Mol Case Stud 2017 05;3(3):a001610

Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1101/mcs.a001610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411691PMC
May 2017

Between-species differences in gene copy number are enriched among functions critical for adaptive evolution in Arabidopsis halleri.

BMC Genomics 2016 12 22;17(Suppl 13):1034. Epub 2016 Dec 22.

Department of Plant Physiology, Ruhr University Bochum, Universitätsstrasse 150, Bochum, 44801, Germany.

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http://dx.doi.org/10.1186/s12864-016-3319-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259951PMC
December 2016

Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with amplification.

Cold Spring Harb Mol Case Stud 2016 11;2(6):a001180

Department of Translational Oncology, National Center for Tumor Diseases (NCT) Heidelberg, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany;; Section for Personalized Oncology, Heidelberg University Hospital, Heidelberg 69120, Germany;; German Cancer Consortium (DKTK), Heidelberg 69120, Germany.

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http://dx.doi.org/10.1101/mcs.a001180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111004PMC
November 2016

150 years of Johann Gregor Mendel's "Versuche über Pflanzen-Hybriden".

Mol Genet Genomics 2017 Feb 11;292(1):1-3. Epub 2016 Oct 11.

Institut für Biologie und Umweltwissenschaften, Fakultät Mathematik und Naturwissenschaften, Carl-von-Ossietzky-Universität Oldenburg, Ammerländer Heerstraße 114-118, 26129, Oldenburg, Germany.

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http://dx.doi.org/10.1007/s00438-016-1254-4DOI Listing
February 2017

Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study.

Eur J Cancer 2016 09 29;65:91-101. Epub 2016 Jul 29.

Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg, 69120, Germany; German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.06.009DOI Listing
September 2016

A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing.

Nat Commun 2015 Dec 9;6:10001. Epub 2015 Dec 9.

CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1038/ncomms10001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682041PMC
December 2015

Iroquois homeobox 2 suppresses cellular motility and chemokine expression in breast cancer cells.

BMC Cancer 2015 Nov 11;15:896. Epub 2015 Nov 11.

Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.

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http://dx.doi.org/10.1186/s12885-015-1907-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642646PMC
November 2015

In Silico Gene Regulatory Network of the Maurer's Cleft Pathway in Plasmodium falciparum.

Evol Bioinform Online 2015 22;11:231-8. Epub 2015 Oct 22.

Department of Computer and Information Sciences, Covenant University, Ota, Ogun State, Nigeria. ; Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Ogun State, Nigeria. ; Department of Applied Bioinformatics, German Cancer Research Centre (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.4137/EBO.S25585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620995PMC
November 2015

Evolutionary conserved gene co-expression drives generation of self-antigen diversity in medullary thymic epithelial cells.

J Autoimmun 2016 Feb 23;67:65-75. Epub 2015 Oct 23.

Division of Developmental Immunology, Tumor Immunology Program, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08968411153004
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http://dx.doi.org/10.1016/j.jaut.2015.10.001DOI Listing
February 2016

Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction.

Immunity 2015 Jun 9;42(6):1048-61. Epub 2015 Jun 9.

Institute for Immunology, Ludwig-Maximilians-University Munich, Goethestrasse 31, 80336 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.05.013DOI Listing
June 2015

Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis.

Cell Stem Cell 2014 Oct 21;15(4):507-522. Epub 2014 Aug 21.

Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany. Electronic address:

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http://www.cell.com/cms/attachment/2035154136/2050496774/mmc
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http://www-huber.embl.de/pub/pdf/CabezasWallscheid2014.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S193459091400301
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http://dx.doi.org/10.1016/j.stem.2014.07.005DOI Listing
October 2014

Intratumor DNA methylation heterogeneity reflects clonal evolution in aggressive prostate cancer.

Cell Rep 2014 Aug 24;8(3):798-806. Epub 2014 Jul 24.

Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; The German Cancer Consortium, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.06.053DOI Listing
August 2014

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.

Nature 2014 Jul 22;511(7510):428-34. Epub 2014 Jun 22.

1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.

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http://www.abta.org/resources/enhancers-hijacking-activates.
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http://www.nature.com/doifinder/10.1038/nature13379
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http://dx.doi.org/10.1038/nature13379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201514PMC
July 2014

circlize Implements and enhances circular visualization in R.

Bioinformatics 2014 Oct 14;30(19):2811-2. Epub 2014 Jun 14.

Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg Center for Personalized Oncology (DKFZ-HIPO) and Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant Center, Heidelberg University, 69120 Heidelberg, Germany Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg Center for Personalized Oncology (DKFZ-HIPO) and Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant Center, Heidelberg University, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btu393DOI Listing
October 2014

Genetic variants in apoptosis-related genes associated with colorectal hyperplasia.

Genes Chromosomes Cancer 2014 Sep 27;53(9):769-78. Epub 2014 May 27.

Institute for Clinical Chemistry, Universitätsmedizin Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, 68167, Germany.

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http://dx.doi.org/10.1002/gcc.22185DOI Listing
September 2014

Cell competition is a tumour suppressor mechanism in the thymus.

Nature 2014 May 14;509(7501):465-70. Epub 2014 May 14.

Division of Cellular Immunology, German Cancer Research Center, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature13317DOI Listing
May 2014

Chromosome 17/17q gain and unaltered profiles in high resolution array-CGH are prognostically informative in neuroblastoma.

Genes Chromosomes Cancer 2014 Aug 15;53(8):639-49. Epub 2014 Apr 15.

Department of Pediatric Oncology and Hematology, Children's Hospital, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1002/gcc.22174DOI Listing
August 2014

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.

Cancer Cell 2014 Mar;25(3):393-405

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ccr.2014.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493053PMC
March 2014