Bellur S Prabhakar - University of Illinois at Chicago

Bellur S Prabhakar

University of Illinois at Chicago

Chicago, Illinois | United States

Main Specialties: Allergy & Immunology, Biotechnology, Public Health

ORCID logohttps://orcid.org/0000-0001-9815-9850

Bellur S Prabhakar - University of Illinois at Chicago

Bellur S Prabhakar

Introduction

Autoimmunity:
Dr. Bellur Prabhakar’s laboratory has been working on autoimmune diseases for over 30 years. A major focus of our research effort has been to identify, clone and characterize autoantigens implicated in different autoimmune diseases. More recently, our work is focused on understanding the role of dendritic cells in modulating immune responses with a particular emphasis on regulatory T cell induction and maintenance.
One of the methods of Treg induction involves treating mice with experimental autoimmune diseases with low doses of GM-CSF which causes selective expansion of CD8a- myeloid dendritic cells and retains them in a semi-matured status (tolerogenic BMDCs). Antigen presentation by these tolerogenic DCs results in selective expansion of Tregs that produce higher amounts of IL-10, which suppresses the pathogenic T cell response and consequently the disease. This modality of treatment has been successfully used to prevent and suppress ongoing, experimental autoimmune thyroiditis in CBA mice and myasthenia gravis in C57/Bl mice; and to prevent type-1 diabetes in NOD mice.
More recently, characterization of tolerogenic BMDCs revealed that they express OX40L and Jagged-1 and signaling mediated by both these ligands are essential for Treg expansion. Interestingly only FOxP3+ Tregs express cognate receptors OX40 and Notch3, and blocking signaling mediated by these receptors also abrogates BMDCs ability to expand Tregs. Using BMDCs from MHC class II-/- mice, we have shown that G-BMDCs induced Treg expansion occurred in the absence of canonical TCR engagement, but required exogenous IL-2.
At the present time our NIH funded program involves elucidating the underlying mechanism of action of OX40 and Notch3 mediated co-signaling in the TCR-independent Treg expansion. We are optimizing expansion of Tregs to test their efficacy in the NOD model of Type 1 diabetes.

Cancer Biology:
The incidence of thyroid cancer is rapidly rising in USA. Patients with differentiated thyroid cancer are successfully treated with thyroidectomy and radioiodine (131I). However, in a proportion of these patients the tumor becomes poorly differentiated (PDTC) and loses its ability to take up radioiodine leading to disease recurrence and death. Additionally, anaplastic thyroid cancer (ATC) accounts for 50% thyroid cancer related deaths and the mean survival of patients with ATC is less than 6 months. Current treatment modalities do not significantly alter this outcome. Therefore, a treatment that can selectively kill cancer cells that are unresponsive to radioiodine treatment such as ATC cells is highly desired.

Map kinase Activating Death Domain containing protein (MADD) is a splice variant (SV) of the IG20 gene which can encode 6 different isoforms. MADD is an Akt substrate and pMADD confers resistance to TRAIL induced apoptosis of cancer cells. Knockdown of MADD or dephosphorylation of pMADD can significantly enhance spontaneous as well as TRAIL-induced apoptosis of several different types of cancer cells. Thyroid cancers have genetic alterations that result in constitutive activation of PI3K/Akt signaling pathways that contribute to tumor formation and progression. These mutations can result in increased phosphorylation of MADD, which could oppose apoptosis in thyroid cancer.

Depletion or dephosphorylation of MADD can significantly enhance TRAIL-induced apoptosis of papillary and follicular thyroid cancer cells. However, the role of MADD, nor how its function is affected by the genetic alterations that enhance Akt activity, in ATC are unknown. Interestingly, the pro-apoptotic effects of TRAIL and/or down modulation of MADD function are primarily seen in cancer cells, and not in normal cells; therefore, they can be used in combination to selectively target cancer cells.

Currently, our VA Merit Review funded program involves studying MADD function in ATC. These studies could provide unique insights for developing MADD targeted therapies to enhance TRAIL sensitivity of ATC.

Primary Affiliation: University of Illinois at Chicago - Chicago, Illinois , United States

Specialties:

Education

Sep 1975 - May 1980
Johns Hopkins University
PhD
Viral Immunology
Apr 1970 - Apr 1973
University of Mysore
Master of Science (MSc)
Medical Microbiology
Mar 1966 - Mar 1970
University of Mysore
Bachelor od Science (BSc)
Biology and Chemistry

Experience

Feb 2019
University of Illinois College of Medicine
Interim Senior Associate Dean for Research
Office of the Dean
Jun 1997 - Aug 2016
University of Illinois at Chicago
Professor and Head
Microbiology and Imunology
May 2013 - Aug 2014
University of Illinois College of Medicine
Associate Dean for Research and Training
Office of the Dean
Aug 2014
University of Illinois College of Medicine
Associate Dean for Technological Innovation and Training
Office of the Dean
Sep 1991 - May 1997
University of Texas Medical Branch at Galveston
Professor
Microbiology and Immunology
Sep 1990 - Sep 1991
University of Texas Medical Center
Associate Professor
Microbiology and Immunology
Sep 1987 - Sep 1990
National Institutes of Health
Senior Investigator with Tenure
Laboratory od Oral Medicine
Sep 1983 - Sep 1987
National Institutes of Health
Senior Staff Fellow
Laboratory of Oral Medicine
Sep 1980 - Sep 1983
National Institutes of Health
Saff Fellow
Laboratory of Oral Medicine
Jul 1979 - Sep 1980
University of Pennsylvania
Post-Doctoral Fellow
Microbiology and Immunology
Jul 1974 - Jul 1979
Johns Hopkins University Bloomberg School of Public Health
Research Assistant
Epidemiology/Infectious Diseases

Publications

103Publications

1828Reads

49Profile Views

1376PubMed Central Citations

Molecular aberrations and signaling cascades implicated in the pathogenesis of anaplastic thyroid cancer.

Biochim Biophys Acta Rev Cancer 2019 12 31;1872(2):188262. Epub 2018 Dec 31.

Department of Microbiology and Immunology, University of Illinois-College of Medicine, Chicago, IL, United States; Jesse Brown VA Medical Center, Chicago, IL, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2018.12.003DOI Listing
December 2019
3 Reads
7.845 Impact Factor

MADD silencing enhances anti-tumor activity of TRAIL in anaplastic thyroid cancer.

Endocr Relat Cancer 2019 06;26(6):551-563

Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, USA.

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https://erc.bioscientifica.com/view/journals/erc/26/6/ERC-18
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http://dx.doi.org/10.1530/ERC-18-0517DOI Listing
June 2019
18 Reads
4.805 Impact Factor

Restoring self-tolerance in autoimmune diseases by enhancing regulatory T-cells.

Cell Immunol 2019 05 29;339:41-49. Epub 2018 Sep 29.

Department of Microbiology and Immunology, University of Illinois - College of Medicine, Chicago, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cellimm.2018.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440877PMC
May 2019
30 Reads
1.924 Impact Factor

Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation.

Cell Mol Immunol 2019 02 26;16(2):138-153. Epub 2018 Mar 26.

Department of Microbiology and Immunology, University of Illinois-College of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1038/cmi.2018.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355936PMC
February 2019
4 Reads
1 Citation
4.112 Impact Factor

Cancer immunotherapy with check point inhibitor can cause autoimmune adverse events due to loss of Treg homeostasis.

Semin Cancer Biol 2019 Feb 1. Epub 2019 Feb 1.

Department of Microbiology and Immunology, University of Illinois-College of Medicine, Chicago, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2019.01.006DOI Listing
February 2019
1 Read
9.330 Impact Factor

Vaccination With Mitoxantrone-Treated Primary Colon Cancer Cells Enhances Tumor-Infiltrating Lymphocytes and Clinical Responses in Colorectal Liver Metastases.

J Surg Res 2019 01 17;233:57-64. Epub 2018 Aug 17.

Division of Surgical Oncology, Department of Surgery, University of Illinois at Chicago, Chicago, Illinois. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2018.07.068DOI Listing
January 2019
2 Reads
1.936 Impact Factor

A comprehensive review on the role of co-signaling receptors and Treg homeostasis in autoimmunity and tumor immunity.

J Autoimmun 2018 12 31;95:77-99. Epub 2018 Aug 31.

Department of Microbiology and Immunology, University of Illinois-College of Medicine, Chicago, IL, USA; Department of Ophthalmology, Associate Dean for Technological Innovation and Training, University of Illinois College of Medicine, Room E-705, (M/C 790), 835 S. Wolcott Ave, Chicago, IL, 60612, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2018.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289740PMC
December 2018
90 Reads
8.410 Impact Factor

Identification of a Novel OX40L Dendritic Cell Subset That Selectively Expands Regulatory T cells.

Sci Rep 2018 10 8;8(1):14940. Epub 2018 Oct 8.

Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.1038/s41598-018-33307-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175872PMC
October 2018
2 Reads
5.080 Impact Factor

Therapeutic advances in anaplastic thyroid cancer: a current perspective.

Mol Cancer 2018 10 23;17(1):154. Epub 2018 Oct 23.

Department of Microbiology and Immunology, University of Illinois-College of Medicine, Chicago, IL, USA.

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https://molecular-cancer.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12943-018-0903-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198524PMC
October 2018
44 Reads
4.260 Impact Factor

Knockdown of Mtfp1 can minimize doxorubicin cardiotoxicity by inhibiting Dnm1l-mediated mitochondrial fission.

J Cell Mol Med 2017 Dec 23;21(12):3394-3404. Epub 2017 Jun 23.

Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1111/jcmm.13250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706585PMC
December 2017
99 Reads
1 Citation

The epigenetic drug Trichostatin A ameliorates experimental autoimmune encephalomyelitis via T cell tolerance induction and impaired influx of T cells into the spinal cord.

Neurobiol Dis 2017 Dec 20;108:1-12. Epub 2017 Jul 20.

Dept. of Surgery, University of Illinois College of Medicine, Chicago, IL 60612, USA; Dept. of Microbiology & Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2017.07.015DOI Listing
December 2017
14 Reads
1 Citation
5.080 Impact Factor

Mitochondrial protein 18 (MTP18) plays a pro-apoptotic role in chemotherapy-induced gastric cancer cell apoptosis.

Oncotarget 2017 Aug 28;8(34):56582-56597. Epub 2017 Apr 28.

Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.18632/oncotarget.17508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593585PMC
August 2017
14 Reads
2 Citations
6.360 Impact Factor

PKC-ѳ is dispensable for OX40L-induced TCR-independent Treg proliferation but contributes by enabling IL-2 production from effector T-cells.

Sci Rep 2017 07 26;7(1):6594. Epub 2017 Jul 26.

Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.1038/s41598-017-05254-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529425PMC
July 2017
7 Reads
1 Citation
5.080 Impact Factor

LIGHT Elevation Enhances Immune Eradication of Colon Cancer Metastases.

Cancer Res 2017 04 1;77(8):1880-1891. Epub 2017 Mar 1.

Department of Surgery, Division of Surgical Oncology, University of Illinois at Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-1655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410174PMC
April 2017
93 Reads
3 Citations
9.330 Impact Factor

An Engineered Herpesvirus Activates Dendritic Cells and Induces Protective Immunity.

Sci Rep 2017 02 2;7:41461. Epub 2017 Feb 2.

Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.1038/srep41461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288694PMC
February 2017
7 Reads
4 Citations
5.080 Impact Factor

Colon cancer cell treatment with rose bengal generates a protective immune response via immunogenic cell death.

Cell Death Dis 2017 02 2;8(2):e2584. Epub 2017 Feb 2.

Department of Surgery, Division of Surgical Oncology, University of Illinois at Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1038/cddis.2016.473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386459PMC
February 2017
8 Reads
1 Citation
5.014 Impact Factor

Soluble OX40L and JAG1 Induce Selective Proliferation of Functional Regulatory T-Cells Independent of canonical TCR signaling.

Sci Rep 2017 01 3;7:39751. Epub 2017 Jan 3.

Department of Microbiology and Immunology, University of Illinois-College of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1038/srep39751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206631PMC
January 2017
52 Reads
7 Citations
5.080 Impact Factor

The mitochondrial ubiquitin ligase plays an anti-apoptotic role in cardiomyocytes by regulating mitochondrial fission.

J Cell Mol Med 2016 12 22;20(12):2278-2288. Epub 2016 Jul 22.

Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.

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http://doi.wiley.com/10.1111/jcmm.12914
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http://dx.doi.org/10.1111/jcmm.12914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134389PMC
December 2016
20 Reads
3 Citations

Targeting the metabolic pathway of human colon cancer overcomes resistance to TRAIL-induced apoptosis.

Cell Death Discov 2016 12;2:16067. Epub 2016 Sep 12.

Department of Surgery, Division of Surgical Oncology, University of Illinois at Chicago, College of Medicine, Chicago, IL 60612, USA; Department of Microbiology & Immunology, University of Illinois at Chicago, College of Medicine, 835S. Wolcott Ave., MC790, Chicago, IL 60612, USA; The Creticos Cancer Center at Advocate Illinois Masonic Medical Center, Chicago, IL 60657, USA.

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http://dx.doi.org/10.1038/cddiscovery.2016.67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018545PMC
September 2016
3 Reads
6 Citations

Age-dependent divergent effects of OX40L treatment on the development of diabetes in NOD mice.

Autoimmunity 2016 08 31;49(5):298-311. Epub 2016 May 31.

a Department of Microbiology and Immunology , University of Illinois College of Medicine , Chicago , IL , USA and.

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http://dx.doi.org/10.1080/08916934.2016.1183657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042830PMC
August 2016
20 Reads
17 Citations
2.714 Impact Factor

Intravaginal Zinc Oxide Tetrapod Nanoparticles as Novel Immunoprotective Agents against Genital Herpes.

J Immunol 2016 06 27;196(11):4566-75. Epub 2016 Apr 27.

Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago, IL 60612; Department of Microbiology and Immunology, University of Illinois, Chicago, IL 60612;

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http://dx.doi.org/10.4049/jimmunol.1502373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875784PMC
June 2016
19 Reads
16 Citations
4.922 Impact Factor

GM-CSF: An immune modulatory cytokine that can suppress autoimmunity.

Cytokine 2015 Oct 22;75(2):261-71. Epub 2015 Jun 22.

Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL 60612, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2015.05.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553090PMC
October 2015
68 Reads
39 Citations
2.664 Impact Factor

Deleted in Breast Cancer 1 Suppresses B Cell Activation through RelB and Is Regulated by IKKα Phosphorylation.

J Immunol 2015 Oct 16;195(8):3685-93. Epub 2015 Sep 16.

Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago IL 60611;

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http://dx.doi.org/10.4049/jimmunol.1500713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642440PMC
October 2015
16 Reads
4 Citations
4.922 Impact Factor

Alternative splicing as a biomarker and potential target for drug discovery.

Acta Pharmacol Sin 2015 Oct 15;36(10):1212-8. Epub 2015 Jun 15.

School of Pharmaceutical Sciences, Xiamen University at Xiang'an, Xiamen 361102, China.

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http://dx.doi.org/10.1038/aps.2015.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648177PMC
October 2015
42 Reads
11 Citations
2.500 Impact Factor

Dual Role of GM-CSF as a Pro-Inflammatory and a Regulatory Cytokine: Implications for Immune Therapy.

J Interferon Cytokine Res 2015 Aug 24;35(8):585-99. Epub 2015 Mar 24.

1 Department of Microbiology and Immunology, College of Medicine, University of Illinois , Chicago, Illinois.

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http://dx.doi.org/10.1089/jir.2014.0149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529096PMC
August 2015
14 Reads
43 Citations
2.000 Impact Factor

Ebola virus outbreak, updates on current therapeutic strategies.

Rev Med Virol 2015 Jul 11;25(4):241-53. Epub 2015 May 11.

Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1002/rmv.1841DOI Listing
July 2015
26 Reads
3 Citations
5.574 Impact Factor

DBC1 is a suppressor of B cell activation by negatively regulating alternative NF-κB transcriptional activity.

J Immunol 2014 Dec 31;193(11):5515-24. Epub 2014 Oct 31.

Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611;

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http://dx.doi.org/10.4049/jimmunol.1401798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259264PMC
December 2014
28 Reads
3 Citations
4.922 Impact Factor

Ad5/48 hexon oncolytic virus expressing sTGFβRIIFc produces reduced hepatic and systemic toxicities and inhibits prostate cancer bone metastases.

Mol Ther 2014 Aug 5;22(8):1504-1517. Epub 2014 May 5.

Gene Therapy Program, Department of Medicine, NorthShore Research Institute, Evanston, Illinois, USA. Electronic address:

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http://dx.doi.org/10.1038/mt.2014.80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435591PMC
August 2014
134 Reads
9 Citations
6.230 Impact Factor

Recombinant IgG2a Fc (M045) multimers effectively suppress experimental autoimmune myasthenia gravis.

J Autoimmun 2014 Aug 2;52:64-73. Epub 2014 Jan 2.

Novartis Institutes for Biomedical Research, 220 Massachusetts Ave, Building 600, 304C, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2013.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518541PMC
August 2014
16 Reads
9 Citations
8.410 Impact Factor

A novel pancreatic β-cell targeting bispecific-antibody (BsAb) can prevent the development of type 1 diabetes in NOD mice.

Clin Immunol 2014 Jul 2;153(1):187-98. Epub 2014 May 2.

Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 606012, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2014.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077286PMC
July 2014
5 Reads
19 Citations
3.672 Impact Factor

IG20/MADD plays a critical role in glucose-induced insulin secretion.

Diabetes 2014 May 30;63(5):1612-23. Epub 2013 Dec 30.

Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL.

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http://dx.doi.org/10.2337/db13-0707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994957PMC
May 2014
4 Reads
6 Citations
8.100 Impact Factor

Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assay.

J Virol 2014 Apr 5;88(8):4353-65. Epub 2014 Feb 5.

Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.1128/JVI.03050-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993759PMC
April 2014
9 Reads
15 Citations
4.440 Impact Factor

MADD is a downstream target of PTEN in triggering apoptosis.

J Cell Biochem 2014 Feb;115(2):261-70

Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, 60612.

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http://dx.doi.org/10.1002/jcb.24657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865079PMC
February 2014
6 Reads
1 Citation
3.263 Impact Factor

MADD knock-down enhances doxorubicin and TRAIL induced apoptosis in breast cancer cells.

PLoS One 2013 15;8(2):e56817. Epub 2013 Feb 15.

Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0056817PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574069PMC
August 2013
16 Reads
7 Citations
3.234 Impact Factor

OX40L/Jagged1 cosignaling by GM-CSF-induced bone marrow-derived dendritic cells is required for the expansion of functional regulatory T cells.

J Immunol 2013 Jun 29;190(11):5516-25. Epub 2013 Apr 29.

Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA.

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http://dx.doi.org/10.4049/jimmunol.1202298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660466PMC
June 2013
13 Reads
23 Citations
4.922 Impact Factor

Human monoclonal antibodies against highly conserved HR1 and HR2 domains of the SARS-CoV spike protein are more broadly neutralizing.

PLoS One 2012 21;7(11):e50366. Epub 2012 Nov 21.

Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0050366PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503966PMC
May 2013
26 Reads
15 Citations
3.234 Impact Factor

Down-modulation of expression, or dephosphorylation, of IG20/MADD in tumor necrosis factor-related apoptosis-inducing ligand-resistant thyroid cancer cells makes them susceptible to treatment with this ligand.

Thyroid 2013 Jan;23(1):70-8

Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA.

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http://dx.doi.org/10.1089/thy.2012.0155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539253PMC
January 2013
44 Reads
5 Citations
4.493 Impact Factor

Impaired regulatory function in circulating CD4(+)CD25(high)CD127(low/-) T cells in patients with myasthenia gravis.

Clin Immunol 2012 Dec 7;145(3):209-23. Epub 2012 Oct 7.

Department of Neurology and Rehabilitation, College of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, IL-60612, USA.

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http://dx.doi.org/10.1016/j.clim.2012.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501560PMC
December 2012
10 Reads
21 Citations
3.672 Impact Factor

Functional defect in regulatory T cells in myasthenia gravis.

Ann N Y Acad Sci 2012 Dec;1274:68-76

Department of Neurology and Rehabilitation, College of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2012.06840.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531815PMC
December 2012
9 Reads
9 Citations
4.313 Impact Factor

Expression of the ring ligase PRAJA2 in thyroid cancer.

J Clin Endocrinol Metab 2012 Nov 4;97(11):4253-9. Epub 2012 Sep 4.

Section of Endocrinology and Metabolism, Department of Internal Medicine, Endocrinology, and Metabolism and Biochemistry, Policlinico Santa Maria alle Scotte, Viale Bracci 1, University of Siena, 53100 Siena, Italy.

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http://dx.doi.org/10.1210/jc.2012-2360DOI Listing
November 2012
28 Reads
5 Citations
6.210 Impact Factor

Granulocyte macrophage colony-stimulating factor treatment of a patient in myasthenic crisis: effects on regulatory T cells.

Muscle Nerve 2012 Sep;46(3):449-53

Department of Neurology and Rehabilitation, University of Illinois Medical Center, 912 South Wood Street, 855N, M/C 796, Chicago, Illinois 60612, USA.

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http://dx.doi.org/10.1002/mus.23488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428740PMC
September 2012
30 Reads
36 Citations
2.283 Impact Factor

Control of mitochondrial activity by miRNAs.

J Cell Biochem 2012 Apr;113(4):1104-10

Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA.

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http://dx.doi.org/10.1002/jcb.24004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325319PMC
April 2012
33 Reads
23 Citations
3.263 Impact Factor

Activation of NF-κB in CD8+ dendritic cells Ex Vivo by the γ134.5 null mutant correlates with immunity against herpes simplex virus 1.

J Virol 2012 Jan 9;86(2):1059-68. Epub 2011 Nov 9.

Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, Illinois, USA.

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January 2012
7 Reads
5 Citations
4.440 Impact Factor

Neutralizing human monoclonal antibodies to severe acute respiratory syndrome coronavirus: target, mechanism of action, and therapeutic potential.

Rev Med Virol 2012 Jan 8;22(1):2-17. Epub 2011 Sep 8.

Centers for Disease Control and Prevention, Measles, Mumps, Rubella and Herpes Virus Laboratory Branch, Atlanta, GA, USA.

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January 2012
1 Read
8 Citations
5.574 Impact Factor

Type 2 deiodinase and host responses of sepsis and acute lung injury.

Am J Respir Cell Mol Biol 2011 Dec 17;45(6):1203-11. Epub 2011 Jun 17.

Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Illinois 60612-7227, USA.

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December 2011
27 Reads
19 Citations
3.985 Impact Factor

GM-CSF-induced regulatory T cells selectively inhibit anti-acetylcholine receptor-specific immune responses in experimental myasthenia gravis.

J Neuroimmunol 2011 Dec 17;240-241:65-73. Epub 2011 Nov 17.

Department of Neurology and Rehabilitation, College of Medicine, University of Illinois at Chicago, Chicago, IL-60612, United States.

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22 Reads
18 Citations
2.470 Impact Factor

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PLoS One 2011 11;6(7):e21949. Epub 2011 Jul 11.

Department of Microbiology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America.

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5 Citations
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Am J Obstet Gynecol 2011 Oct 27;205(4):362.e12-25. Epub 2011 May 27.

Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.

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10 Citations
4.704 Impact Factor

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J Interferon Cytokine Res 2011 Oct 8;31(10):721-31. Epub 2011 Aug 8.

Department of Microbiology and Immunology, Research Resources Center, College of Medicine, University of Illinois at Chicago, Illinois, USA.

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October 2011
6 Reads
14 Citations
2.000 Impact Factor

The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.

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Department of Microbiology and Immunology, University of Illinois at Chicago, 835 S. Wolcott Ave., MC 790, Chicago, IL 60612, USA.

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July 2011
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5 Citations

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J Leukoc Biol 2011 Feb 2;89(2):235-49. Epub 2010 Nov 2.

Department of Microbiology and Immunology, University of Illinois, Chicago, Chicago, IL 60612, USA.

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February 2011
8 Reads
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4.290 Impact Factor

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Biochem Biophys Res Commun 2010 Sep 4;399(4):629-36. Epub 2010 Aug 4.

Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.

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September 2010
30 Reads
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Akt-phosphorylated mitogen-activated kinase-activating death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas-associated death domain (FADD) association with death receptor 4.

J Biol Chem 2010 Jul 18;285(29):22713-22. Epub 2010 May 18.

Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois 60612, USA.

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9 Reads
18 Citations
4.573 Impact Factor

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J Immunol 2010 Jun 14;184(12):6695-708. Epub 2010 May 14.

Department of Surgery, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.

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June 2010
18 Reads
8 Citations
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The VP35 protein of Ebola virus impairs dendritic cell maturation induced by virus and lipopolysaccharide.

J Gen Virol 2010 Feb 14;91(Pt 2):352-61. Epub 2009 Oct 14.

Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, IL 60612, USA.

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February 2010
9 Reads
18 Citations
3.183 Impact Factor

miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway.

PLoS Genet 2010 Jan 8;6(1):e1000795. Epub 2010 Jan 8.

Department of Physiology, Shantou University School of Medicine, Shantou, China.

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January 2010
11 Reads
110 Citations

Nanodisc-incorporated hemagglutinin provides protective immunity against influenza virus infection.

J Virol 2010 Jan;84(1):361-71

Department of Microbiology and Immunology, University of Illinois, Chicago, IL 60612, USA.

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January 2010
61 Reads
15 Citations
4.440 Impact Factor

Identification of a new region of SARS-CoV S protein critical for viral entry.

J Mol Biol 2009 Dec 21;394(4):600-5. Epub 2009 Oct 21.

Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.

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December 2009
23 Reads
13 Citations
4.333 Impact Factor

Potential utility and limitations of thyroid cancer cell lines as models for studying thyroid cancer.

Thyroid 2009 Dec;19(12):1333-42

Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago , Chicago, Illinois, USA.

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December 2009
9 Reads
21 Citations
4.493 Impact Factor

Human monoclonal antibodies to SARS-coronavirus inhibit infection by different mechanisms.

Virology 2009 Nov 12;394(1):39-46. Epub 2009 Sep 12.

Department of Microbiology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.

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November 2009
13 Reads
9 Citations
3.321 Impact Factor

Acetylcholine receptor-alpha subunit expression in myasthenia gravis: a role for the autoantigen in pathogenesis?

Muscle Nerve 2009 Aug;40(2):279-86

Division of Neuromuscular Diseases, Department of Neurology and Rehabilitation, 912 South Wood Street, M/C 796, University of Illinois at Chicago, Chicago, Illinois 60612, USA.

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August 2009
2 Reads
3 Citations
2.283 Impact Factor

Modulation of dendritic cells using granulocyte-macrophage colony-stimulating factor (GM-CSF) delays type 1 diabetes by enhancing CD4+CD25+ regulatory T cell function.

Clin Immunol 2009 May 25;131(2):260-70. Epub 2009 Jan 25.

Department of Microbiology and Immunology (MC790), College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.

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May 2009
3 Reads
36 Citations
3.672 Impact Factor

MADD, a splice variant of IG20, is indispensable for MAPK activation and protection against apoptosis upon tumor necrosis factor-alpha treatment.

J Biol Chem 2009 May 16;284(20):13533-41. Epub 2009 Mar 16.

Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA.

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May 2009
45 Reads
14 Citations
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Knockdown of IG20 gene expression renders thyroid cancer cells susceptible to apoptosis.

J Clin Endocrinol Metab 2009 Apr 3;94(4):1467-71. Epub 2009 Feb 3.

Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA.

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April 2009
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6.210 Impact Factor

GM-CSF-induced CD11c+CD8a--dendritic cells facilitate Foxp3+ and IL-10+ regulatory T cell expansion resulting in suppression of autoimmune thyroiditis.

Int Immunol 2009 Mar 27;21(3):269-82. Epub 2009 Jan 27.

Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.

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March 2009
9 Reads
34 Citations
2.540 Impact Factor

Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors.

Bioorg Med Chem Lett 2008 Oct 28;18(20):5684-8. Epub 2008 Aug 28.

Department of Chemistry, Purdue University, 560 Oval drive, West Lafayette, IN 47907, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745596PMC
October 2008
8 Reads
12 Citations
2.420 Impact Factor

A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication.

Proc Natl Acad Sci U S A 2008 Oct 13;105(42):16119-24. Epub 2008 Oct 13.

Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago, IL 60607, USA.

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October 2008
19 Reads
49 Citations
9.810 Impact Factor

Strategies for treating autoimmunity: novel insights from experimental myasthenia gravis.

Ann N Y Acad Sci 2008 ;1132:276-82

Section of Neuromuscular Disease, Department of Neurology and Rehabilitation Medicine, University of Illinois, Chicago, IL 60612, USA.

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September 2008
12 Reads
9 Citations
4.313 Impact Factor

Regulation of apoptosis and caspase-8 expression in neuroblastoma cells by isoforms of the IG20 gene.

Cancer Res 2008 Sep;68(18):7352-61

Department of Neurology, University of Illinois at Chicago, Chicago, Illinois 60523, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760438PMC
September 2008
3 Reads
13 Citations
9.330 Impact Factor

Regulatory T cells induced by GM-CSF suppress ongoing experimental myasthenia gravis.

Clin Immunol 2008 Aug 27;128(2):172-80. Epub 2008 May 27.

Department of Neurology and Rehabilitation, College of Medicine, University of Illinois at Chicago, Chicago, IL-60612, USA.

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http://dx.doi.org/10.1016/j.clim.2008.03.509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2536633PMC
August 2008
7 Reads
30 Citations
3.672 Impact Factor

Preferential costimulation by CD80 results in IL-10-dependent TGF-beta1(+) -adaptive regulatory T cell generation.

J Immunol 2008 May;180(10):6566-76

Department of Surgery, College of Medicine, University of Illinois, Chicago, IL 60612, USA.

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http://dx.doi.org/10.4049/jimmunol.180.10.6566DOI Listing
May 2008
6 Reads
22 Citations
4.922 Impact Factor

Down-regulation of catalase and oxidative modification of protein kinase CK2 lead to the failure of apoptosis repressor with caspase recruitment domain to inhibit cardiomyocyte hypertrophy.

J Biol Chem 2008 Mar 1;283(10):5996-6004. Epub 2008 Jan 1.

Division of Cardiovascular Research, National Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

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March 2008
6 Reads
31 Citations
4.573 Impact Factor

Role of IG20 splice variants in TRAIL resistance.

Clin Cancer Res 2008 Jan;14(2):347-51

Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-0493DOI Listing
January 2008
3 Reads
12 Citations
8.722 Impact Factor

Identification of human cell responses to hexavalent chromium.

Environ Mol Mutagen 2007 Oct;48(8):650-7

College of Medicine, Research Resources Center, University of Illinois, Chicago, Illinois, USA.

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http://dx.doi.org/10.1002/em.20331DOI Listing
October 2007
5 Reads
9 Citations
2.630 Impact Factor

Enhanced engagement of CTLA-4 induces antigen-specific CD4+CD25+Foxp3+ and CD4+CD25- TGF-beta 1+ adaptive regulatory T cells.

J Immunol 2007 Oct;179(8):5191-203

Department of Surgery, University of Illinois, Chicago 60612, USA.

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October 2007
8 Reads
17 Citations
4.922 Impact Factor

Identification of human cell responses to benzene and benzene metabolites.

Genomics 2007 Sep 15;90(3):324-33. Epub 2007 Jun 15.

Department of Medicine, University of Illinois, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1016/j.ygeno.2007.05.003DOI Listing
September 2007
6 Reads
10 Citations
2.284 Impact Factor

Generation and characterization of human monoclonal neutralizing antibodies with distinct binding and sequence features against SARS coronavirus using XenoMouse.

Virology 2007 Apr 11;361(1):93-102. Epub 2006 Dec 11.

Department of Microbiology and Immunology (MC790) College of Medicine, University of Illinois at Chicago, Room E705. 835 S. Wolcott AveChicago, IL 60612, USA.

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http://dx.doi.org/10.1016/j.virol.2006.09.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103293PMC
April 2007
20 Reads
6 Citations
3.321 Impact Factor

MADD/DENN splice variant of the IG20 gene is a negative regulator of caspase-8 activation. Knockdown enhances TRAIL-induced apoptosis of cancer cells.

J Biol Chem 2007 Apr 21;282(16):11715-21. Epub 2007 Feb 21.

Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA.

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April 2007
2 Reads
15 Citations
4.573 Impact Factor

Diversity in the complementarity-determining region 3 (CDR3) of antibodies from mice with evolving anti-thyroid-stimulating hormone receptor antibody responses.

Endocrinology 2007 Feb 26;148(2):752-61. Epub 2006 Oct 26.

Department of Microbiology and Immunology (M/C 790), Room E-709, Building 935, 835 South Wolcott Avenue, Chicago, Illinois 60612, USA.

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http://dx.doi.org/10.1210/en.2006-1096DOI Listing
February 2007
12 Reads
2 Citations
4.503 Impact Factor

Suppression of experimental autoimmune myasthenia gravis by granulocyte-macrophage colony-stimulating factor is associated with an expansion of FoxP3+ regulatory T cells.

J Immunol 2006 Oct;177(8):5296-306

Department of Neurology and Rehabilitation, University of Illinois, Chicago, IL 60612, USA.

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October 2006
11 Reads
34 Citations
4.922 Impact Factor

IL-10-producing CD4+CD25+ regulatory T cells play a critical role in granulocyte-macrophage colony-stimulating factor-induced suppression of experimental autoimmune thyroiditis.

J Immunol 2005 Jun;174(11):7006-13

Departments of Microbiology, University of Illinois, Chicago, 60612, USA.

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June 2005
4 Reads
44 Citations
4.922 Impact Factor

DC-SIGN, but not sDC-SIGN, can modulate IL-2 production from PMA- and anti-CD3-stimulated primary human CD4 T cells.

Int Immunol 2005 Jun 8;17(6):769-78. Epub 2005 Jun 8.

Department of Microbiology and Immunology, University of Illinois, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1093/intimm/dxh258DOI Listing
June 2005
6 Reads
4 Citations
2.540 Impact Factor

Characterization of a recombinant Yersinia enterocolitica lipoprotein; implications for its role in autoimmune response against thyrotropin receptor.

Autoimmunity 2004 Sep-Nov;37(6-7):515-20

Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, 60612, USA.

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http://dx.doi.org/10.1080/08916930410001728074DOI Listing
May 2005
5 Reads
3 Citations
2.714 Impact Factor

IG20 (MADD splice variant-5), a proapoptotic protein, interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISC.

Oncogene 2004 Aug;23(36):6083-94

Department of Microbiology and Immunology, University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1038/sj.onc.1207804DOI Listing
August 2004
7 Reads
12 Citations
8.460 Impact Factor

Targeted CTLA-4 engagement induces CD4+CD25+CTLA-4high T regulatory cells with target (allo)antigen specificity.

J Immunol 2004 Aug;173(4):2866-76

Departments of Surgery and Microbiology and Immunology, University of Illinois, Chicago, IL 60612, USA.

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August 2004
1 Read
17 Citations
4.922 Impact Factor

Apoptosis and autoimmune disorders.

Autoimmunity 2003 Sep-Nov;36(6-7):323-30

Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1080/08916930310001604207DOI Listing
April 2004
3 Reads
4 Citations
2.714 Impact Factor

Modulation of dendritic cell function and cytokine production to prevent thyroid autoimmunity.

Autoimmunity 2003 Sep-Nov;36(6-7):389-96

Department of Surgery, University of Illinois at Chicago, Chicago, IL 60612, USA.

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April 2004
5 Reads
2 Citations
2.714 Impact Factor

IG20, in contrast to DENN-SV, (MADD splice variants) suppresses tumor cell survival, and enhances their susceptibility to apoptosis and cancer drugs.

Oncogene 2004 Feb;23(5):1076-87

Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA.

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February 2004
11 Reads
15 Citations
8.460 Impact Factor

Upon thyrotropin binding the thyrotropin receptor is internalized and localized to endosome.

Endocrinology 2004 Feb 23;145(2):1003-10. Epub 2003 Oct 23.

Department of Microbiology and Immunology (M/C 790), College of Medicine, University of Illinois at Chicago, Room E-705, 835 South Wolcott Avenue, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1210/en.2003-1217DOI Listing
February 2004
2 Reads
2 Citations
4.503 Impact Factor

IG20, a MADD splice variant, increases cell susceptibility to gamma-irradiation and induces soluble mediators that suppress tumor cell growth.

Cancer Res 2003 Dec;63(24):8768-76

Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois 60612, USA.

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December 2003
8 Reads
9 Citations
9.330 Impact Factor

Current perspective on the pathogenesis of Graves' disease and ophthalmopathy.

Endocr Rev 2003 Dec;24(6):802-35

Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612-7344, USA.

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http://dx.doi.org/10.1210/er.2002-0020DOI Listing
December 2003
2 Reads
76 Citations
21.060 Impact Factor

Targeting colon cancer cells with genistein-17.1A immunoconjugate.

Int J Oncol 2003 May;22(5):955-9

Department of Surgical Oncology, College of Medcine, University of Illinois at Chicago, Chicago, IL 60612, USA.

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May 2003
60 Reads
3.025 Impact Factor

Targeted engagement of CTLA-4 prevents autoimmune thyroiditis.

Int Immunol 2003 May;15(5):641-54

Department of Surgery, University of Illinois at Chicago, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1093/intimm/dxg061DOI Listing
May 2003
7 Reads
13 Citations
2.540 Impact Factor

Absence of IL-4, and not suppression of the Th2 response, prevents development of experimental autoimmune Graves' disease.

J Immunol 2003 Feb;170(4):2195-204

Department of Microbiology and Immunology, University of Illinois College of Medicine, 835 South Wolcott, Chicago, IL 60612, USA.

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February 2003
1 Read
9 Citations
4.922 Impact Factor

CD80 and CD86 C domains play an important role in receptor binding and co-stimulatory properties.

Int Immunol 2003 Feb;15(2):167-75

Departments of Surgery, and Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA.

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February 2003
3 Reads
6 Citations
2.540 Impact Factor

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8
Peifeng Li
Peifeng Li

Fourth Military Medical University

8
Muthusamy Thiruppathi
Muthusamy Thiruppathi

College of Medicine

8