Belen Peral

Belen Peral

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Belen Peral

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Mitoproteomics: Tackling Mitochondrial Dysfunction in Human Disease.

Oxid Med Cell Longev 2018 8;2018:1435934. Epub 2018 Nov 8.

Instituto de Investigaciones Biomédicas Alberto Sols (IIBM), Consejo Superior de Investigaciones Científicas & Universidad Autónoma de Madrid (CSIC-UAM), 28029 Madrid, Spain.

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http://dx.doi.org/10.1155/2018/1435934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250043PMC
January 2019

N-acetylcysteine inhibits kinase phosphorylation during 3T3-L1 adipocyte differentiation.

Redox Rep 2017 Nov 27;22(6):265-271. Epub 2016 Sep 27.

a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales , Universidad de Buenos Aires - IQUIBICEN, CONICET , Buenos Aires , Argentina.

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http://dx.doi.org/10.1080/13510002.2016.1223267DOI Listing
November 2017

Differential proteomic and oxidative profiles unveil dysfunctional protein import to adipocyte mitochondria in obesity-associated aging and diabetes.

Redox Biol 2017 04 18;11:415-428. Epub 2016 Dec 18.

Instituto de Investigaciones Biomédicas, Alberto Sols, (IIBM); Consejo Superior de Investigaciones Científicas & Universidad Autónoma de Madrid (CSIC-UAM), Madrid 28029, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2016.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220168PMC
April 2017

Proteome-wide alterations on adipose tissue from obese patients as age-, diabetes- and gender-specific hallmarks.

Sci Rep 2016 05 10;6:25756. Epub 2016 May 10.

Instituto de Investigaciones Biomédicas, Alberto Sols, (IIBM); Consejo Superior de Investigaciones Científicas &Universidad Autónoma de Madrid (CSIC-UAM), Madrid, 28029, Spain.

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http://dx.doi.org/10.1038/srep25756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861930PMC
May 2016

Parathyroid Hormone-Related Protein, Human Adipose-Derived Stem Cells Adipogenic Capacity and Healthy Obesity.

J Clin Endocrinol Metab 2015 Jun 17;100(6):E826-35. Epub 2015 Apr 17.

Unidad de Gestión Clínica Endocrinología y Nutrición (M.M.R.R., R.E., L.G.S., L.C.A., W.O.O., S.L., M.C.P., F.J.T.), Instituto de Investigación Biomédica de Málaga, Complejo Hospitalario de Málaga (Virgen de la Victoria), Universidad de Málaga, CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Málaga, Spain; Instituto de Investigaciones Biomédicas Alberto Sols (M.G.S., E.G.S., B.P.), Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain; Servicio de Cirugía General y Digestiva (R.d.L.D.), Hospital Universitario Virgen de la Victoria, Málaga, Spain; Lipids and Atherosclerosis Unit (E.M.Y.S.), IMIBIC/Reina Sofia University Hospital/University of Córdoba and CIBEROBN, Instituto de Salud Carlos III, Córdoba, Spain; and Departamento de Diabetes, Endocrinología y Nutrición (J.M.F.R.), Institut d'Investigació Biomèdica de Girona, CIBEROBN e ISCIII, Girona, Spain.

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http://dx.doi.org/10.1210/jc.2014-4132DOI Listing
June 2015

Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation.

Am J Physiol Endocrinol Metab 2015 May 24;308(9):E756-69. Epub 2015 Feb 24.

Department of Biochemistry and Molecular Biology, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, Barcelona, Spain; Institut de Biomedicina de la Universitat de Barcelona Fisiopatología de la Obesidad y la Nutrición, Instituto de Salud Carlos III, Madrid, Spain;

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http://ajpendo.physiology.org/content/ajpendo/308/9/E756.ful
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http://ajpendo.physiology.org/content/ajpendo/early/2015/02/
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http://ajpendo.physiology.org/lookup/doi/10.1152/ajpendo.003
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http://dx.doi.org/10.1152/ajpendo.00362.2014DOI Listing
May 2015

Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPARγ gene expression.

J Mol Med (Berl) 2015 Jan 25;93(1):83-92. Epub 2014 Sep 25.

Department of Diabetes, Endocrinology and Nutrition (UDEN), Institut d'Investigació Biomèdica de Girona (IdIBGi), CIBERobn (CB06/03/010) and Instituto de Salud Carlos III (ISCIII), Carretera de França s/n, 17007, Girona, Spain,

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http://dx.doi.org/10.1007/s00109-014-1207-5DOI Listing
January 2015

The MRC1/CD68 ratio is positively associated with adipose tissue lipogenesis and with muscle mitochondrial gene expression in humans.

PLoS One 2013 12;8(8):e70810. Epub 2013 Aug 12.

Service of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona (IdIBGi), CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII), Girona, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070810PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741275PMC
March 2014

Breast cancer 1 (BrCa1) may be behind decreased lipogenesis in adipose tissue from obese subjects.

PLoS One 2012 30;7(5):e33233. Epub 2012 May 30.

Service of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona, CIBER de la Fisiopatología de la Obesidad y Nutrición, and Instituto de Salud Carlos III, Girona, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033233PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364252PMC
October 2012

Attenuated metabolism is a hallmark of obesity as revealed by comparative proteomic analysis of human omental adipose tissue.

J Proteomics 2012 Jan 1;75(3):783-95. Epub 2011 Oct 1.

Instituto de Investigaciones Biomédicas, Alberto Sols, Consejo Superior de Investigaciones Científicas & Universidad Autónoma de Madrid, E-28029 Madrid, Spain.

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http://dx.doi.org/10.1016/j.jprot.2011.09.016DOI Listing
January 2012

Decreased STAMP2 expression in association with visceral adipose tissue dysfunction.

J Clin Endocrinol Metab 2011 Nov 17;96(11):E1816-25. Epub 2011 Aug 17.

Service of Diabetes, Endocrinology, and Nutrition, Institut d'Investigació Biomèdica de Girona, CIBEROBN and Instituto de Salud Carlos III, 17007 Girona, Spain.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2011-0310DOI Listing
November 2011

Study of the potential association of adipose tissue GLP-1 receptor with obesity and insulin resistance.

Endocrinology 2011 Nov 23;152(11):4072-9. Epub 2011 Aug 23.

University Hospital of Tarragona Joan XXIII, IISPV, Rovira i Virgili University, Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, 43007 Tarragona, Spain.

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http://dx.doi.org/10.1210/en.2011-1070DOI Listing
November 2011

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.

Authors:
Tuomas O Kilpeläinen M Carola Zillikens Alena Stančákova Francis M Finucane Janina S Ried Claudia Langenberg Weihua Zhang Jacques S Beckmann Jian'an Luan Liesbeth Vandenput Unnur Styrkarsdottir Yanhua Zhou Albert Vernon Smith Jing-Hua Zhao Najaf Amin Sailaja Vedantam So-Youn Shin Talin Haritunians Mao Fu Mary F Feitosa Meena Kumari Bjarni V Halldorsson Emmi Tikkanen Massimo Mangino Caroline Hayward Ci Song Alice M Arnold Yurii S Aulchenko Ben A Oostra Harry Campbell L Adrienne Cupples Kathryn E Davis Angela Döring Gudny Eiriksdottir Karol Estrada José Manuel Fernández-Real Melissa Garcia Christian Gieger Nicole L Glazer Candace Guiducci Albert Hofman Steve E Humphries Bo Isomaa Leonie C Jacobs Antti Jula David Karasik Magnus K Karlsson Kay-Tee Khaw Lauren J Kim Mika Kivimäki Norman Klopp Brigitte Kühnel Johanna Kuusisto Yongmei Liu Osten Ljunggren Mattias Lorentzon Robert N Luben Barbara McKnight Dan Mellström Braxton D Mitchell Vincent Mooser José Maria Moreno Satu Männistö Jeffery R O'Connell Laura Pascoe Leena Peltonen Belén Peral Markus Perola Bruce M Psaty Veikko Salomaa David B Savage Robert K Semple Tatjana Skaric-Juric Gunnar Sigurdsson Kijoung S Song Timothy D Spector Ann-Christine Syvänen Philippa J Talmud Gudmar Thorleifsson Unnur Thorsteinsdottir André G Uitterlinden Cornelia M van Duijn Antonio Vidal-Puig Sarah H Wild Alan F Wright Deborah J Clegg Eric Schadt James F Wilson Igor Rudan Samuli Ripatti Ingrid B Borecki Alan R Shuldiner Erik Ingelsson John-Olov Jansson Robert C Kaplan Vilmundur Gudnason Tamara B Harris Leif Groop Douglas P Kiel Fernando Rivadeneira Mark Walker Inês Barroso Peter Vollenweider Gérard Waeber John C Chambers Jaspal S Kooner Nicole Soranzo Joel N Hirschhorn Kari Stefansson H-Erich Wichmann Claes Ohlsson Stephen O'Rahilly Nicholas J Wareham Elizabeth K Speliotes Caroline S Fox Markku Laakso Ruth J F Loos

Nat Genet 2011 Jun 26;43(8):753-60. Epub 2011 Jun 26.

Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262230PMC
June 2011

Subcutaneous fat shows higher thyroid hormone receptor-alpha1 gene expression than omental fat.

Obesity (Silver Spring) 2009 Dec 9;17(12):2134-41. Epub 2009 Apr 9.

Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomédica de Girona and CIBEROBN (CB06/03/010), Instituto de Salud Carlos III, Girona, Spain.

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http://www.zen-bio.com/pubs/Subcutaneous%20Fat%20Shows%20Hig
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http://doi.wiley.com/10.1038/oby.2009.110
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http://dx.doi.org/10.1038/oby.2009.110DOI Listing
December 2009

Study of the proinflammatory role of human differentiated omental adipocytes.

J Cell Biochem 2009 Aug;107(6):1107-17

Department of Diabetes, Endocrinology and Nutrition, Hospital of Girona Dr. Josep Trueta, Biomedical Research Institute and CIBEROBN Fisiopatología de la Obesidad y Nutrición CB06/03/010, Girona, Spain.

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http://www.zen-bio.com/pubs/Study%20of%20the%20proinflammato
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http://doi.wiley.com/10.1002/jcb.22208
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http://dx.doi.org/10.1002/jcb.22208DOI Listing
August 2009

Tackling the human adipose tissue proteome to gain insight into obesity and related pathologies.

Expert Rev Proteomics 2009 Aug;6(4):353-61

Instituto de Investigaciones Biomédicas, Alberto Sols, CSIC & Universidad Autónoma de Madrid, Arturo Duperier, 4, E-28029 Madrid, Spain.

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http://dx.doi.org/10.1586/epr.09.53DOI Listing
August 2009

Differential proteomics of omental and subcutaneous adipose tissue reflects their unalike biochemical and metabolic properties.

J Proteome Res 2009 Apr;8(4):1682-93

Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas & Universidad Autónoma de Madrid, E-28029 Madrid, Spain.

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http://dx.doi.org/10.1021/pr800942kDOI Listing
April 2009

Proteomic analysis of human omental adipose tissue in the polycystic ovary syndrome using two-dimensional difference gel electrophoresis and mass spectrometry.

Hum Reprod 2008 Mar 22;23(3):651-61. Epub 2007 Dec 22.

Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, E-28029 Madrid, Spain.

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http://dx.doi.org/10.1093/humrep/dem380DOI Listing
March 2008

Proteomics and genomics: A hypothesis-free approach to the study of the role of visceral adiposity in the pathogenesis of the polycystic ovary syndrome.

Proteomics Clin Appl 2008 Mar;2(3):444-55

Department of Endocrinology, Hospital Ramón y Cajal and University of Alcalá, Madrid, Spain.

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http://dx.doi.org/10.1002/prca.200780031DOI Listing
March 2008

Differential gene expression profile in omental adipose tissue in women with polycystic ovary syndrome.

J Clin Endocrinol Metab 2007 Jan 24;92(1):328-37. Epub 2006 Oct 24.

Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, E-28029 Madrid, Spain.

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http://dx.doi.org/10.1210/jc.2006-1665DOI Listing
January 2007

Characterization of a 6p21 translocation breakpoint in a family with idiopathic generalized epilepsy.

Epilepsy Res 2003 Oct;56(2-3):155-63

Laboratorio de Neurología, Fundación Jiménez Díaz, Avda. Reyes Católicos 2, Madrid 28040, Spain.

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October 2003

Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism.

J Clin Endocrinol Metab 2002 Aug;87(8):3977-83

Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas, 28029 Madrid, Spain.

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http://dx.doi.org/10.1210/jcem.87.8.8715DOI Listing
August 2002

Common single nucleotide polymorphisms in intron 3 of the calpain-10 gene influence hirsutism.

Fertil Steril 2002 Mar;77(3):581-7

Department of Endocrinology, Hospital Ramón y Cajal, Madrid, Spain.

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http://dx.doi.org/10.1016/s0015-0282(01)03206-xDOI Listing
March 2002