Bekim Sadikovic

Bekim Sadikovic

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Bekim Sadikovic

Bekim Sadikovic

Publications by authors named "Bekim Sadikovic"

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58Publications

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Genotypes of chronic progressive external ophthalmoplegia in a large adult-onset cohort.

Mitochondrion 2019 11 12;49:227-231. Epub 2019 Sep 12.

Department of Pediatrics, McMaster University, Hamilton, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.mito.2019.09.002DOI Listing
November 2019

Genome-wide DNA methylation and RNA analyses enable reclassification of two variants of uncertain significance in a patient with clinical Kabuki syndrome.

Hum Mutat 2019 10 3;40(10):1684-1689. Epub 2019 Jul 3.

Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.

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http://dx.doi.org/10.1002/humu.23833DOI Listing
October 2019

Implementation of Epilepsy Multigene Panel Testing in Ontario, Canada.

Can J Neurol Sci 2019 Oct 7:1-8. Epub 2019 Oct 7.

Division of Neurology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1017/cjn.2019.304DOI Listing
October 2019

CPEO - Like mitochondrial myopathy associated with m.8340G>A mutation.

Mitochondrion 2019 05 6;46:69-72. Epub 2018 Mar 6.

Molecular Genetics Laboratory, Molecular Diagnostics Division, London Health Sciences Centre, Children's Health Research Institute, London, Ontario, Canada.

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http://dx.doi.org/10.1016/j.mito.2018.02.008DOI Listing
May 2019

DNA methylation signatures in mendelian developmental disorders as a diagnostic bridge between genotype and phenotype.

Epigenomics 2019 Apr 15;11(5):563-575. Epub 2019 Mar 15.

Departments of Pediatrics, Biochemistry & Oncology, Western University, London, ON, N6A 3K7, Canada.

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http://dx.doi.org/10.2217/epi-2018-0192DOI Listing
April 2019

Complete elimination of a pathogenic homoplasmic mtDNA mutation in one generation.

Mitochondrion 2019 03 1;45:18-21. Epub 2018 Feb 1.

Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15677249173032
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http://dx.doi.org/10.1016/j.mito.2018.01.010DOI Listing
March 2019

Genomic data in prognostic models-what is lost in translation? The case of deletion 17p and mutant TP53 in chronic lymphocytic leukaemia.

Br J Haematol 2019 Mar 5. Epub 2019 Mar 5.

Department of Pathology and Laboratory Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.

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http://dx.doi.org/10.1111/bjh.15827DOI Listing
March 2019

A Case of -Positive Myelodysplastic/Myeloproliferative Neoplasm with Ring Sideroblasts and Thrombocytosis

Turk J Haematol 2019 02 23;36(1):48-49. Epub 2018 Nov 23.

Western University, Schulich School of Medicine, Department of Pathology and Laboratory Medicine, London, Ontario, Canada

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http://dx.doi.org/10.4274/tjh.galenos.2018.2018.0267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373514PMC
February 2019

MALAT1: An Epigenetic Regulator of Inflammation in Diabetic Retinopathy.

Sci Rep 2018 04 25;8(1):6526. Epub 2018 Apr 25.

Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.

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http://dx.doi.org/10.1038/s41598-018-24907-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916949PMC
April 2018

Genomic DNA Methylation-Derived Algorithm Enables Accurate Detection of Malignant Prostate Tissues.

Front Oncol 2018 23;8:100. Epub 2018 Apr 23.

Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada.

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http://dx.doi.org/10.3389/fonc.2018.00100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925605PMC
April 2018

Genomic DNA Methylation Signatures Enable Concurrent Diagnosis and Clinical Genetic Variant Classification in Neurodevelopmental Syndromes.

Am J Hum Genet 2018 01;102(1):156-174

Department of Pathology and Laboratory Medicine, Western University, London, ON N6A5C1, Canada; Molecular Genetics Laboratory, Molecular Diagnostics Division, London Health Sciences Centre, London, ON N6A5W9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777983PMC
January 2018

Clinical Validation of a Genome-Wide DNA Methylation Assay for Molecular Diagnosis of Imprinting Disorders.

J Mol Diagn 2017 11 12;19(6):848-856. Epub 2017 Aug 12.

Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada; Molecular Genetics Laboratory, Molecular Diagnostics Division, London Health Sciences Centre, London, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2017.07.002DOI Listing
November 2017

Clinical Validation of Copy Number Variant Detection from Targeted Next-Generation Sequencing Panels.

J Mol Diagn 2017 11 15;19(6):905-920. Epub 2017 Aug 15.

Molecular Genetics Laboratory, Molecular Diagnostics Division, London Health Sciences Centre, London, Ontario, Canada; Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2017.07.004DOI Listing
November 2017

Clinical evaluation of a hemochromatosis next-generation sequencing gene panel.

Eur J Haematol 2017 Mar 11;98(3):228-234. Epub 2016 Nov 11.

Department of Medicine, Western University, London, ON, Canada.

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http://dx.doi.org/10.1111/ejh.12820DOI Listing
March 2017

Constitutional Epi/Genetic Conditions: Genetic, Epigenetic, and Environmental Factors.

J Pediatr Genet 2017 Mar 8;6(1):30-41. Epub 2016 Nov 8.

Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada; London Regional Cancer Program, London Health Sciences Centre, London, Ontario, Canada; Children's Health Research Institute, London, Ontario, Canada.

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http://dx.doi.org/10.1055/s-0036-1593849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288004PMC
March 2017

The defining DNA methylation signature of Floating-Harbor Syndrome.

Sci Rep 2016 12 9;6:38803. Epub 2016 Dec 9.

Department of Pathology and Laboratory Medicine, Western University, 1151 Richmond Street, London, N6A 3K7, Canada.

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http://dx.doi.org/10.1038/srep38803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146968PMC
December 2016

DNA methylation analysis in constitutional disorders: Clinical implications of the epigenome.

Crit Rev Clin Lab Sci 2016 12;53(3):147-65. Epub 2016 Jan 12.

a Departments of Pathology and Laboratory Medicine .

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http://dx.doi.org/10.3109/10408363.2015.1113496DOI Listing
November 2016

Clinical Validation of Fragile X Syndrome Screening by DNA Methylation Array.

J Mol Diagn 2016 11 29;18(6):834-841. Epub 2016 Aug 29.

Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada; London Regional Cancer Program, London Health Sciences Center, London, Ontario, Canada; Children's Health Research Institute, London Health Sciences Center, London, Ontario, Canada; Molecular Genetics Laboratory, London Health Sciences Center, London, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2016.06.005DOI Listing
November 2016

Movement Disorders Associated With Hemochromatosis.

Can J Neurol Sci 2016 Nov;43(6):801-808

1Department of Clinical Neurological Sciences,Western University,London,ON,Canada.

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http://dx.doi.org/10.1017/cjn.2016.286DOI Listing
November 2016

Clinical Next-Generation Sequencing Pipeline Outperforms a Combined Approach Using Sanger Sequencing and Multiplex Ligation-Dependent Probe Amplification in Targeted Gene Panel Analysis.

J Mol Diagn 2016 09 2;18(5):657-667. Epub 2016 Jul 2.

Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada; Molecular Genetics Laboratory, Molecular Diagnostics Division, London Health Sciences Centre, Children's Health Research Institute, London, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2016.04.002DOI Listing
September 2016

Gender and BCR-ABL transcript type are correlated with molecular response to imatinib treatment in patients with chronic myeloid leukemia.

Eur J Haematol 2016 Apr 3;96(4):360-6. Epub 2015 Jul 3.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1111/ejh.12597DOI Listing
April 2016

A 42-year-old man with elevated ferritin.

CMAJ 2015 Aug 6;187(11):820-821. Epub 2014 Oct 6.

Department of Medicine (Lanktree, Crowther) and Pathology (Sadikovic, Crowther), McMaster University, Hamilton, Ont.

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http://dx.doi.org/10.1503/cmaj.140259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527905PMC
August 2015

Prader-Willi syndrome and Tay-Sachs disease in association with mixed maternal uniparental isodisomy and heterodisomy 15 in a girl who also had isochromosome Xq.

Am J Med Genet A 2015 Jan 6;167A(1):180-4. Epub 2014 Oct 6.

Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1002/ajmg.a.36790DOI Listing
January 2015

Mutation Update for UBE3A variants in Angelman syndrome.

Hum Mutat 2014 Dec;35(12):1407-17

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1002/humu.22687DOI Listing
December 2014

Genomics and epigenomics in pediatric oncology and clinical laboratory genetics.

Clin Biochem 2014 Jun 20;47(9):731-2. Epub 2014 May 20.

Department of Pathology and Molecular Medicine and Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1016/j.clinbiochem.2014.05.033DOI Listing
June 2014

Array comparative genomic hybridization in osteosarcoma.

Methods Mol Biol 2013 ;973:227-47

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA,

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http://link.springer.com/10.1007/978-1-62703-281-0_15
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http://dx.doi.org/10.1007/978-1-62703-281-0_15DOI Listing
July 2013

Immunohistochemical expression and cluster analysis of mesenchymal and neural stem cell-associated proteins in pediatric soft tissue sarcomas.

Pediatr Dev Pathol 2011 Jul-Aug;14(4):259-72. Epub 2010 Dec 16.

Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.2350/10-08-0890-OA.1DOI Listing
December 2011

Identification of a microRNA signature associated with progression of leukoplakia to oral carcinoma.

Hum Mol Genet 2009 Dec 23;18(24):4818-29. Epub 2009 Sep 23.

Division of Applied Molecular Oncology, Toronto General Hospital, Ontario Cancer Institute, The University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1093/hmg/ddp446DOI Listing
December 2009

Identification of interactive networks of gene expression associated with osteosarcoma oncogenesis by integrated molecular profiling.

Hum Mol Genet 2009 Jun 13;18(11):1962-75. Epub 2009 Mar 13.

Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada M5G 1X8.

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http://dx.doi.org/10.1093/hmg/ddp117DOI Listing
June 2009

Epigenetic mapping and functional analysis in a breast cancer metastasis model using whole-genome promoter tiling microarrays.

Breast Cancer Res 2008 18;10(4):R62. Epub 2008 Jul 18.

London Regional Cancer Program, Victoria Research Laboratories, London Health Sciences Centre, 790 Commissioners Road East, London, Ontario, N6A 4L6, Canada.

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http://dx.doi.org/10.1186/bcr2121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575535PMC
April 2009

Decitabine-induced demethylation of 5' CpG island in GADD45A leads to apoptosis in osteosarcoma cells.

Neoplasia 2008 May;10(5):471-80

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373908PMC
http://dx.doi.org/10.1593/neo.08174DOI Listing
May 2008

Genome-wide H3K9 histone acetylation profiles are altered in benzopyrene-treated MCF7 breast cancer cells.

J Biol Chem 2008 Feb 7;283(7):4051-60. Epub 2007 Dec 7.

London Regional Cancer Program, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M707506200
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http://dx.doi.org/10.1074/jbc.M707506200DOI Listing
February 2008

DNA methylation analysis using CpG microarrays is impaired in benzopyrene exposed cells.

Toxicol Appl Pharmacol 2007 Dec 23;225(3):300-9. Epub 2007 Aug 23.

Department of Biochemistry, University of Western Ontario, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S0041008X0700374
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http://dx.doi.org/10.1016/j.taap.2007.08.013DOI Listing
December 2007

Benzopyrene exposure disrupts DNA methylation and growth dynamics in breast cancer cells.

Toxicol Appl Pharmacol 2006 Nov 30;216(3):458-68. Epub 2006 Jun 30.

Department of Biochemistry, University of Western Ontario, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S0041008X0600203
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http://dx.doi.org/10.1016/j.taap.2006.06.012DOI Listing
November 2006

Chemically induced DNA hypomethylation in breast carcinoma cells detected by the amplification of intermethylated sites.

Breast Cancer Res 2004 30;6(4):R329-37. Epub 2004 Apr 30.

The London Regional Cancer Centre, Child Health Research Institute, and the Department of Biochemistry, Paediatrics and Oncology, at the University of Western Ontario, London, Ontario, Canada.

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http://breast-cancer-research.biomedcentral.com/articles/10.
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http://dx.doi.org/10.1186/bcr799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC468641PMC
November 2004

Characterization of functional elements in the neurofibromatosis (NF1) proximal promoter region.

Oncogene 2004 Jan;23(2):330-9

London Regional Cancer Centre, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1038/sj.onc.1207053DOI Listing
January 2004