Beifen Shen

Beifen Shen

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Tim-3 promotes Lister Monocytogenes immune evasion by suppressing MHC-I.

J Infect Dis 2019 Oct 5. Epub 2019 Oct 5.

Institute of Military Cognition and Brain Sciences, Beijing, China.

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http://dx.doi.org/10.1093/infdis/jiz512DOI Listing
October 2019

Magnetic quantum dot based lateral flow assay biosensor for multiplex and sensitive detection of protein toxins in food samples.

Biosens Bioelectron 2019 Oct 3;146:111754. Epub 2019 Oct 3.

College of Life Sciences, Anhui Agricultural University, Hefei, 230036, PR China; Beijing Institute of Radiation Medicine, Beijing, 100850, PR China; Beijing Key Laboratory of New Molecular Diagnosis Technologies for Infectious Diseases, Beijing, 100850, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bios.2019.111754DOI Listing
October 2019

Spliceosome protein Eftud2 promotes colitis-associated tumorigenesis by modulating inflammatory response of macrophage.

Mucosal Immunol 2019 Sep 5;12(5):1164-1173. Epub 2019 Jul 5.

State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, 100850, Beijing, PR China.

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http://dx.doi.org/10.1038/s41385-019-0184-yDOI Listing
September 2019

A novel human anti-AXL monoclonal antibody attenuates tumour cell migration.

Scand J Immunol 2019 Aug 7;90(2):e12777. Epub 2019 Jun 7.

State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, China.

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http://dx.doi.org/10.1111/sji.12777DOI Listing
August 2019

Engineered AXL-Fc variants that abolish the AXL/Gas6 interaction suppress tumor cell migration.

Oncol Lett 2019 Jun 15;17(6):5784-5792. Epub 2019 Apr 15.

State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P.R. China.

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http://dx.doi.org/10.3892/ol.2019.10255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507473PMC
June 2019

Monoclonal antibody against human Tim-3 enhances antiviral immune response.

Scand J Immunol 2019 Feb 4;89(2):e12738. Epub 2019 Jan 4.

Institute of Beijing Brain Sciences, Beijing, China.

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http://dx.doi.org/10.1111/sji.12738DOI Listing
February 2019

RACK1 deficiency synergizes with all-trans retinoic acid to induce apoptosis in human acute promyelocytic leukemia cells.

Mol Cell Biochem 2019 Jan 17;451(1-2):155-163. Epub 2018 Jul 17.

Department of Molecular Immunology, Beijing Institute of Basic Medical Sciences, Beijing, 100850, People's Republic of China.

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http://link.springer.com/10.1007/s11010-018-3402-0
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http://dx.doi.org/10.1007/s11010-018-3402-0DOI Listing
January 2019

Increased mTOR cancels out the effect of reduced Xbp-1 on antibody secretion in IL-1α-deficient B cells.

Cell Immunol 2018 06 24;328:9-17. Epub 2018 Feb 24.

Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing 100850, China. Electronic address:

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http://dx.doi.org/10.1016/j.cellimm.2018.02.015DOI Listing
June 2018

CD19 regulates ADAM28-mediated Notch2 cleavage to control the differentiation of marginal zone precursors to MZ B cells.

J Cell Mol Med 2017 Dec 14;21(12):3658-3669. Epub 2017 Jul 14.

Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.

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http://dx.doi.org/10.1111/jcmm.13276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706524PMC
December 2017

Both Notch1 and its ligands in B cells promote antibody production.

Mol Immunol 2017 11 31;91:17-23. Epub 2017 Aug 31.

Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing 100850, China. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2017.08.021DOI Listing
November 2017

B cells regulate thymic CD8T cell differentiation in lupus-prone mice.

Oncotarget 2017 Oct 5;8(52):89486-89499. Epub 2017 Jul 5.

Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.

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http://dx.doi.org/10.18632/oncotarget.19002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685686PMC
October 2017

Multi-parametric analysis reveals enhanced G2-phase arrest of an optimized anti-HER2 antibody to inhibit breast cancer.

Biotechnol Lett 2017 Sep 30;39(9):1309-1323. Epub 2017 May 30.

Laboratory of Molecular Immunology, Institute of Basic Medical Sciences, P. O. Box 130 (3), Taiping Road #27 Haidian, Beijing, 100850, China.

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http://dx.doi.org/10.1007/s10529-017-2364-8DOI Listing
September 2017

B cell activating factor (BAFF) selects IL-10B cells over IL-10B cells during inflammatory responses.

Mol Immunol 2017 05 12;85:18-26. Epub 2017 Feb 12.

Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing 100850, China. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2017.02.002DOI Listing
May 2017

Foxd3 suppresses interleukin-10 expression in B cells.

Immunology 2017 04 12;150(4):478-488. Epub 2017 Jan 12.

Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.

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http://dx.doi.org/10.1111/imm.12701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343362PMC
April 2017

Structure-based virtual screening and characterization of a novel IL-6 antagonistic compound from synthetic compound database.

Drug Des Devel Ther 2016 15;10:4091-4100. Epub 2016 Dec 15.

Department of Molecular Immunology, Beijing Institute of Basic Medical Sciences.

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http://dx.doi.org/10.2147/DDDT.S118457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5170619PMC
March 2017

Tim-3 inhibits macrophage control of Listeria monocytogenes by inhibiting Nrf2.

Sci Rep 2017 02 16;7:42095. Epub 2017 Feb 16.

Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.

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http://www.nature.com/articles/srep42095
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http://dx.doi.org/10.1038/srep42095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311873PMC
February 2017

A Comparison of Biological Activity of B Lymphocyte Stimulator (BLyS) Antagonist Peptibodies and the Elucidation of Possible BLyS Binding Sites.

Protein Pept Lett 2016 ;23(1):17-23

Department of Molecular and Cellular Pharmacology, Tianjin University, No. 92 Weijin Road, Nankai District, Tianjin, 300072, P.R. China.

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http://dx.doi.org/10.2174/0929866522666151026122347DOI Listing
October 2016

Metabotropic glutamate receptor 3 is involved in B-cell-related tumor apoptosis.

Int J Oncol 2016 Oct 15;49(4):1469-78. Epub 2016 Jul 15.

Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing 100850, P.R. China.

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http://dx.doi.org/10.3892/ijo.2016.3623DOI Listing
October 2016

Neddylation is required for herpes simplex virus type I (HSV-1)-induced early phase interferon-beta production.

Cell Mol Immunol 2016 09 11;13(5):578-83. Epub 2015 May 11.

Department of Molecular Immunology, Institute of Basic Medical Sciences, 27 Taiping Road, Beijing 100850, P. R. China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037273PMC
http://dx.doi.org/10.1038/cmi.2015.35DOI Listing
September 2016

Anti-HER3 Monoclonal Antibody Inhibits Acquired Trastuzumab-Resistant Gynecologic Cancers.

Technol Cancer Res Treat 2016 08 3;15(4):573-82. Epub 2015 Jun 3.

Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing 100850, China

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http://dx.doi.org/10.1177/1533034615588422DOI Listing
August 2016

A novel IL-23p19/Ebi3 (IL-39) cytokine mediates inflammation in Lupus-like mice.

Eur J Immunol 2016 06 13;46(6):1343-50. Epub 2016 Apr 13.

Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.

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http://dx.doi.org/10.1002/eji.201546095DOI Listing
June 2016

The NEDD8-activating enzyme inhibitor MLN4924 induces G2 arrest and apoptosis in T-cell acute lymphoblastic leukemia.

Oncotarget 2016 Apr;7(17):23812-24

Department of Molecular Immunology, Institute of Basic Medical Sciences, Beijing 100850, P. R. China.

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http://dx.doi.org/10.18632/oncotarget.8068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029665PMC
April 2016

Pre-existing CD19-independent GL7(-) Breg cells are expanded during inflammation and in mice with lupus-like disease.

Mol Immunol 2016 Mar 4;71:54-63. Epub 2016 Feb 4.

Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing 100850, China. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2016.01.011DOI Listing
March 2016

Two-mAb cocktail protects macaques against the Makona variant of Ebola virus.

Sci Transl Med 2016 Mar;8(329):329ra33

Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada. National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada. Department of Immunology, University of Manitoba, Winnipeg, Manitoba R3E 0T5, Canada. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-4238, USA.

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http://dx.doi.org/10.1126/scitranslmed.aad9875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814125PMC
March 2016

A Cytomegalovirus Peptide-Specific Antibody Alters Natural Killer Cell Homeostasis and Is Shared in Several Autoimmune Diseases.

Cell Host Microbe 2016 Mar;19(3):400-8

Department of Rheumatology and Immunology, People's Hospital, Peking University, Beijing 100044, China. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2016.02.005DOI Listing
March 2016

RACK1 Promotes Autophagy by Enhancing the Atg14L-Beclin 1-Vps34-Vps15 Complex Formation upon Phosphorylation by AMPK.

Cell Rep 2015 Nov 5;13(7):1407-1417. Epub 2015 Nov 5.

Department of Molecular Immunology, Institute of Basic Medical Sciences, 27 Taiping Road, Beijing 100850, PRC. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.10.011DOI Listing
November 2015

Ligation of metabotropic glutamate receptor 3 (Grm3) ameliorates lupus-like disease by reducing B cells.

Clin Immunol 2015 Oct 9;160(2):142-54. Epub 2015 Jun 9.

Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing 100850, China. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2015.05.016DOI Listing
October 2015

Tim-3 promotes intestinal homeostasis in DSS colitis by inhibiting M1 polarization of macrophages.

Clin Immunol 2015 Oct 21;160(2):328-35. Epub 2015 Jul 21.

Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2015.07.008DOI Listing
October 2015

IL-15-secreting γδT cells induce memory T cells in experimental allergic encephalomyelitis (EAE) mice.

Mol Immunol 2015 Aug 18;66(2):402-8. Epub 2015 May 18.

Laboratory of Immunology, Institute of Basic Medical Sciences, PO Box 130 (3), Taiping Road #27, Beijing 100850, China. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2015.04.021DOI Listing
August 2015

A novel anti-TNF scFv constructed with human antibody frameworks and antagonistic peptides.

Immunol Res 2015 Jul;62(3):377-85

Department of Molecular Immunology, Institute of Basic Medical Sciences, Taiping Road, Beijing, 100850, People's Republic of China.

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http://link.springer.com/content/pdf/10.1007%2Fs12026-015-86
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http://link.springer.com/10.1007/s12026-015-8667-8
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http://dx.doi.org/10.1007/s12026-015-8667-8DOI Listing
July 2015

Monoclonal antibody, mAb 4C13, an effective detoxicant antibody against ricin poisoning.

Vaccine 2015 Jul 30;33(32):3836-42. Epub 2015 Jun 30.

Beijing Institute of Basic Medical Sciences, Beijing 100850, China.

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http://dx.doi.org/10.1016/j.vaccine.2015.06.096DOI Listing
July 2015

Improving Trastuzumab's Stability Profile by Removing the Two Degradation Hotspots.

J Pharm Sci 2015 Jun 26;104(6):1960-1970. Epub 2015 Mar 26.

Beijing Mabworks Biotech Company Ltd., Economic-Technological Development Area, Beijing 101111, China. Electronic address:

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http://dx.doi.org/10.1002/jps.24435DOI Listing
June 2015

Interaction of CD5 and CD72 is involved in regulatory T and B cell homeostasis.

Immunol Invest 2014 20;43(7):705-16. Epub 2014 Jun 20.

Laboratory of Immunology, Institute of Basic Medical Sciences , Beijing , China .

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http://dx.doi.org/10.3109/08820139.2014.917096DOI Listing
May 2015

Endotoxic shock-expanded murine CD11c low CD45RB + regulatory dendritic cells modulate inflammatory T cell responses through multiple mechanisms.

Sci Rep 2015 May 29;5:10653. Epub 2015 May 29.

Department of Molecular Immunology, Institute of Basic Medical Sciences, 27 Taiping Road, Beijing 100850, P. R. China.

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http://dx.doi.org/10.1038/srep10653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448501PMC
May 2015

The role of C5a in acute lung injury induced by highly pathogenic viral infections.

Emerg Microbes Infect 2015 May 6;4(5):e28. Epub 2015 May 6.

Laboratory of Immunology, Institute of Basic Medical Sciences , Beijing 100850, China.

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http://dx.doi.org/10.1038/emi.2015.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451266PMC
May 2015

Critical role for thymic CD19+CD5+CD1dhiIL-10+ regulatory B cells in immune homeostasis.

J Leukoc Biol 2015 Mar 16;97(3):547-56. Epub 2014 Dec 16.

*Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China; Department of Rheumatology, First Hospital of Jilin University, Changchun, China; Department of Immunology, Medical College of Henan University, Kaifeng, China; and State Key Laboratory of Toxicology and Medical Countermeasures, Beijing 100850, China

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http://dx.doi.org/10.1189/jlb.3A0414-213RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477891PMC
March 2015

Novel IL-6-secreting γδT cells increased in patients with atherosclerotic cerebral infarction.

Mol Med Rep 2015 Feb 29;11(2):1497-503. Epub 2014 Oct 29.

Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China.

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http://dx.doi.org/10.3892/mmr.2014.2796DOI Listing
February 2015

The comparison of BLyS-binding peptides from phage display library and computer-aided design on BLyS-TACI interaction.

Int Immunopharmacol 2015 Feb 19;24(2):219-223. Epub 2014 Dec 19.

Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.intimp.2014.12.013DOI Listing
February 2015

Anti-IGF-1R monoclonal antibody inhibits the carcinogenicity activity of acquired trastuzumab-resistant SKOV3.

J Ovarian Res 2014 Nov 26;7:103. Epub 2014 Nov 26.

Laboratory of Immunology, Institute of Basic Medical Sciences, PO Box 130(3), Taiping Road #27, Beijing, 100850, China.

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http://dx.doi.org/10.1186/s13048-014-0103-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260252PMC
November 2014

Structure-based affinity maturation of a chimeric anti-ricin antibody C4C13.

J Biomol Struct Dyn 2014 25;32(3):416-23. Epub 2013 Mar 25.

a Institute of Basic Medical Sciences , 100850 , Beijing , PR China .

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http://dx.doi.org/10.1080/07391102.2013.771380DOI Listing
August 2014

A Single-Chain Antibody Using LoxP511 as the Linker Enables Large-Content Phage Library Construction via Cre/LoxP Recombination.

J Biomol Screen 2014 Jul 4;19(6):839-46. Epub 2014 Feb 4.

Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China Laboratory of Cellular and Molecular Immunology, Institute of Immunology, Henan University, Kaifeng, China.

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http://dx.doi.org/10.1177/1087057114520974DOI Listing
July 2014

Combination of TACI-IgG and anti-IL-15 treats murine lupus by reducing mature and memory B cells.

Cell Immunol 2014 May-Jun;289(1-2):140-4. Epub 2014 Apr 12.

Department of Rheumatology, First Hospital of Jilin University, Changchun 130021, China. Electronic address:

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http://dx.doi.org/10.1016/j.cellimm.2014.03.017DOI Listing
July 2014

Chronic psychological stress induces the accumulation of myeloid-derived suppressor cells in mice.

PLoS One 2013 18;8(9):e74497. Epub 2013 Sep 18.

Department of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, P. R. China ; Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, P. R. China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074497PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776856PMC
June 2014

Potent anti-angiogenesis and anti-tumor activity of a novel human anti-VEGF antibody, MIL60.

Cell Mol Immunol 2014 May 10;11(3):285-93. Epub 2014 Mar 10.

Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.

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http://dx.doi.org/10.1038/cmi.2014.6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085495PMC
May 2014

BAFF suppresses IL-15 expression in B cells.

J Immunol 2014 May 26;192(9):4192-201. Epub 2014 Mar 26.

Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing 100850, China;

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http://www.jimmunol.org/content/early/2014/03/26/jimmunol.13
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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1302132
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http://dx.doi.org/10.4049/jimmunol.1302132DOI Listing
May 2014

Identify the key amino acid of BAFF binding with TACI.

Cell Immunol 2013 Jul-Aug;284(1-2):84-90. Epub 2013 Jun 14.

Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing 100850, China.

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http://dx.doi.org/10.1016/j.cellimm.2013.06.003DOI Listing
March 2014

BAFF maintains T-cell survival by inducing OPN expression in B cells.

Mol Immunol 2014 Feb 28;57(2):129-37. Epub 2013 Sep 28.

Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing 100850, China; Department of Rheumatology, First Hospital of Jilin University, Changchun 130021, China.

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http://dx.doi.org/10.1016/j.molimm.2013.08.014DOI Listing
February 2014

Tumor-derived GM-CSF promotes inflammatory colon carcinogenesis via stimulating epithelial release of VEGF.

Cancer Res 2014 Feb 23;74(3):716-26. Epub 2013 Dec 23.

Authors' Affiliations: Department of Immunology, Institute of Basic Medical Sciences, Beijing; Department of Immunology, School of Basic Medical Sciences, Central South University, Changsha; Center of Molecular Biology, Inner Mongolia Medical College, Hohhot, People's Republic of China; and Department of Pathology, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1459DOI Listing
February 2014

Pharmacological characteristics and efficacy of a novel anti-angiogenic antibody FD006 in corneal neovascularization.

BMC Biotechnol 2014 Feb 27;14:17. Epub 2014 Feb 27.

Department of Ophthalmology, General Hospital of People's Liberation Army, No,28 Fuxing Road, Haidian District, Beijing 100853, China.

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http://dx.doi.org/10.1186/1472-6750-14-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942068PMC
February 2014

Cyclic AMP suppresses TGF-β-mediated adaptive Tregs differentiation through inhibiting the activation of ERK and JNK.

Cell Immunol 2013 Sep-Oct;285(1-2):42-8. Epub 2013 Sep 6.

Department of Molecular Immunology, Institute of Basic Medical Sciences, 27 Taiping Road, Beijing 100850, PR China.

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http://dx.doi.org/10.1016/j.cellimm.2013.08.006DOI Listing
January 2014

GM-CSF facilitates the development of inflammation-associated colorectal carcinoma.

Oncoimmunology 2014 Jan 7;3(1):e28186. Epub 2014 Mar 7.

Department of Immunology; Institute of Basic Medical Sciences; Beijing, China.

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http://dx.doi.org/10.4161/onci.28186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000268PMC
January 2014

RACK1 promotes the proliferation of THP1 acute myeloid leukemia cells.

Mol Cell Biochem 2013 Dec 3;384(1-2):197-202. Epub 2013 Sep 3.

Department of Immunology, College of Basic Medical Sciences, Central South University, Changsha, 410078, People's Republic of China.

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http://link.springer.com/content/pdf/10.1007/s11010-013-1798
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http://link.springer.com/10.1007/s11010-013-1798-0
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http://dx.doi.org/10.1007/s11010-013-1798-0DOI Listing
December 2013

Tim-3: an activation marker and activation limiter of innate immune cells.

Front Immunol 2013 Dec 10;4:449. Epub 2013 Dec 10.

Department of Immunology, Beijing Institute of Basic Medical Sciences , Beijing , China.

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http://dx.doi.org/10.3389/fimmu.2013.00449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857553PMC
December 2013

Affinity maturation of antiHER2 monoclonal antibody MIL5 using an epitope-specific synthetic phage library by computational design.

J Biomol Struct Dyn 2013 24;31(5):511-21. Epub 2012 Sep 24.

Laboratory of Immunology, Institute of Basic Medical Sciences, P.O. Box 130(3), Taiping Road #27, Beijing 100850, China.

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http://www.tandfonline.com/doi/abs/10.1080/07391102.2012.706
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http://dx.doi.org/10.1080/07391102.2012.706073DOI Listing
October 2013

T cell Ig mucin-3 promotes homeostasis of sepsis by negatively regulating the TLR response.

J Immunol 2013 Mar 30;190(5):2068-79. Epub 2013 Jan 30.

Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.

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http://dx.doi.org/10.4049/jimmunol.1202661DOI Listing
March 2013

Dysregulated Tim-3 expression and its correlation with imbalanced CD4 helper T cell function in ulcerative colitis.

Clin Immunol 2012 Dec 18;145(3):230-40. Epub 2012 Sep 18.

Department of Molecular Immunology, Institute of Basic Medical Sciences, Beijing 100850, China.

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http://dx.doi.org/10.1016/j.clim.2012.09.001DOI Listing
December 2012

Arg9 facilitates the translocation and downstream signal inhibition of an anti-HER2 single chain antibody.

BMC Res Notes 2012 Jul 2;5:336. Epub 2012 Jul 2.

Department of Immunology, School of Basic Medical ScienÎ, Wuhan University, Wuhan, 430071, China.

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http://dx.doi.org/10.1186/1756-0500-5-336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477046PMC
July 2012

The peptide derived from erbB2 auto-inhibitor herstatin shared in the same epitope and function with functional antibody 2C4.

Mol Biotechnol 2012 Jun;51(2):174-82

Institute of Basic Medical Sciences, Beijing 100850, People's Republic of China.

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http://dx.doi.org/10.1007/s12033-011-9454-yDOI Listing
June 2012

Nocodazole increases the ERK activity to enhance MKP-1expression which inhibits p38 activation induced by TNF-α.

Mol Cell Biochem 2012 May;364(1-2):373-80

Department of Biomedicine, Institute of Frontier Medical Sciences, Jilin University, Changchun 130021, People's Republic of China.

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http://dx.doi.org/10.1007/s11010-012-1239-5DOI Listing
May 2012

Modulation of IFN-γ receptor 1 expression by AP-2α influences IFN-γ sensitivity of cancer cells.

Am J Pathol 2012 Feb 16;180(2):661-71. Epub 2011 Dec 16.

Department of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, China.

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http://dx.doi.org/10.1016/j.ajpath.2011.10.040DOI Listing
February 2012

SHP limits TLR signaling, an inducible transcriptional corepressor.

Cell Mol Immunol 2011 Nov 22;8(6):445-6. Epub 2011 Aug 22.

Department of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, China.

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http://dx.doi.org/10.1038/cmi.2011.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012932PMC
November 2011

γδT-cell function in sepsis is modulated by C5a receptor signalling.

Immunology 2011 Jul 19;133(3):340-9. Epub 2011 Apr 19.

Department of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, China.

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http://doi.wiley.com/10.1111/j.1365-2567.2011.03445.x
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http://dx.doi.org/10.1111/j.1365-2567.2011.03445.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112343PMC
July 2011

Identification of conformational core epitope Lys⁶⁸ in C5a based on the 3-D modeling complex C5a and its functional antibody F20.

Mol Immunol 2011 Jul 6;48(12-13):1377-83. Epub 2011 May 6.

Department of Immunology, Institute of Basic Medical Sciences, Beijing, China.

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http://dx.doi.org/10.1016/j.molimm.2011.03.013DOI Listing
July 2011

Blockade of complement activation product C5a activity using specific antibody attenuates intestinal damage in trinitrobenzene sulfonic acid induced model of colitis.

Lab Invest 2011 Mar 22;91(3):472-83. Epub 2010 Nov 22.

Department of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, People's Republic of China.

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http://dx.doi.org/10.1038/labinvest.2010.183DOI Listing
March 2011

The β2-adrenergic receptor and Her2 comprise a positive feedback loop in human breast cancer cells.

Breast Cancer Res Treat 2011 Jan 17;125(2):351-62. Epub 2010 Mar 17.

Department of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, People's Republic of China.

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http://dx.doi.org/10.1007/s10549-010-0822-2DOI Listing
January 2011

Metastasis-related miRNAs, active players in breast cancer invasion, and metastasis.

Cancer Metastasis Rev 2010 Dec;29(4):785-99

Department of Molecular Immunology, Institute of Basic Medical Sciences, Taiping Road 27, Beijing 100850, People's Republic of China.

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http://dx.doi.org/10.1007/s10555-010-9265-9DOI Listing
December 2010

Regulation of IL-8 production by complement-activated product, C5a, in vitro and in vivo during sepsis.

Clin Immunol 2010 Oct 29;137(1):157-65. Epub 2010 Jun 29.

Department of Molecular Immunology, Institute of Basic Medical Sciences, Taiping Road, No. 27, Beijing 100850, People's Republic of China.

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http://dx.doi.org/10.1016/j.clim.2010.05.012DOI Listing
October 2010

Catecholamine up-regulates MMP-7 expression by activating AP-1 and STAT3 in gastric cancer.

Mol Cancer 2010 Oct 12;9:269. Epub 2010 Oct 12.

Department of Molecular Immunology, Institute of Basic Medical Sciences, Beijing 100850, PR China.

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http://dx.doi.org/10.1186/1476-4598-9-269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964618PMC
October 2010

MEKK3 overexpression contributes to the hyperresponsiveness of IL-12-overproducing cells and CD4+ T conventional cells in nonobese diabetic mice.

J Immunol 2010 Sep 18;185(6):3554-63. Epub 2010 Aug 18.

Department of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, People's Republic of China.

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http://dx.doi.org/10.4049/jimmunol.1000431DOI Listing
September 2010

Novel anti-CD20 antibody TGLA with enhanced antibody-dependent cell-mediated cytotoxicity mediates potent anti-lymphoma activity.

Cancer Lett 2010 Aug 3;294(1):66-73. Epub 2010 Mar 3.

Institute of Basic Medical Sciences, Beijing, China.

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http://dx.doi.org/10.1016/j.canlet.2010.01.023DOI Listing
August 2010

Intronic miR-301 feedback regulates its host gene, ska2, in A549 cells by targeting MEOX2 to affect ERK/CREB pathways.

Biochem Biophys Res Commun 2010 Jun 12;396(4):978-82. Epub 2010 May 12.

Beijing Institute of Basic Medical Sciences, No. 27 Taiping Road, Beijing 100850, China.

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http://dx.doi.org/10.1016/j.bbrc.2010.05.037DOI Listing
June 2010

Helpers of the cellular gatekeeper-miRNAs dance in P53 network.

Biochim Biophys Acta 2010 Apr 16;1805(2):218-25. Epub 2009 Dec 16.

Department of Molecular Immunology, Institute of Basic Medical Sciences, Beijing 100850, People's Republic of China.

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http://dx.doi.org/10.1016/j.bbcan.2009.12.001DOI Listing
April 2010

Complement C5a regulates IL-17 by affecting the crosstalk between DC and gammadelta T cells in CLP-induced sepsis.

Eur J Immunol 2010 Apr;40(4):1079-88

Department of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, P R China.

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http://dx.doi.org/10.1002/eji.200940015DOI Listing
April 2010

Construction and expression of a spliced variant of Epstein-Barr virus bzlf1 and preparation of its polyclonal antibody.

Prep Biochem Biotechnol 2010 ;40(1):46-56

Institute of Basic Medical Sciences, Beijing, PR China.

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http://dx.doi.org/10.1080/10826060903392780DOI Listing
March 2010

Involvement of T cell Ig Mucin-3 (Tim-3) in the negative regulation of inflammatory bowel disease.

Clin Immunol 2010 Feb 13;134(2):169-77. Epub 2009 Nov 13.

Department of Molecular Immunology, Institute of Basic Medical Sciences, Beijing 100850, China.

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http://dx.doi.org/10.1016/j.clim.2009.09.012DOI Listing
February 2010

The novel non-mitogenic anti-CD3 antibody, mini-yCD3, delivers a partial TCR signal.

Int Immunopharmacol 2010 Feb 12;10(2):200-6. Epub 2009 Nov 12.

Institute of Basic Medical Sciences, Beijing, PR China.

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http://dx.doi.org/10.1016/j.intimp.2009.10.016DOI Listing
February 2010

Selective unresponsiveness to the inhibition of p38 MAPK activation by cAMP helps L929 fibroblastoma cells escape TNF-alpha-induced cell death.

Mol Cancer 2010 Jan 13;9. Epub 2010 Jan 13.

Department of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, PR China.

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http://dx.doi.org/10.1186/1476-4598-9-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818697PMC
January 2010

Basal c-Jun NH2-terminal protein kinase activity is essential for survival and proliferation of T-cell acute lymphoblastic leukemia cells.

Mol Cancer Ther 2009 Dec;8(12):3214-22

Department of Molecular Immunology, Institute of Basic Medical Sciences, 27 Taiping Road, Beijing 100850, People's Republic of China.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-09
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http://dx.doi.org/10.1158/1535-7163.MCT-09-0408DOI Listing
December 2009